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Your search keyword '"Rodgers, Ursula R."' showing total 12 results
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12 results on '"Rodgers, Ursula R."'

1. Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase

Author

Ritzefeld, Markus, primary, Zhang, Leran, additional, Xiao, Zhangping, additional, Andrei, Sebastian A., additional, Boyd, Olivia, additional, Masumoto, Naoko, additional, Rodgers, Ursula R., additional, Artelsmair, Markus, additional, Sefer, Lea, additional, Hayes, Angela, additional, Gavriil, Efthymios-Spyridon, additional, Raynaud, Florence I., additional, Burke, Rosemary, additional, Blagg, Julian, additional, Rzepa, Henry S., additional, Siebold, Christian, additional, Magee, Anthony I., additional, Lanyon-Hogg, Thomas, additional, and Tate, Edward W., additional

Published
2024
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10. Membrane bound O-acyltransferases and their inhibitors.

Author

Naoko Masumoto, Lanyon-Hogg, Thomas, Rodgers, Ursula R., Konitsiotis, Antonios D., Magee, Anthony I., and Tate, Edward W.

Subjects
ACYLTRANSFERASES, ENZYME inhibitors, MEMBRANE proteins, ENZYME kinetics, PALMITOYLATION
Abstract

Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin Oacyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes. [ABSTRACT FROM AUTHOR]

Published
2015
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12. Expression of recombinant MMP-28 in mammalian cells.

Author

Rodgers UR and Clark IM

Subjects
Cell Line, Tumor, Cloning, Molecular, DNA, Complementary genetics, Enzyme Activation, Humans, Mutant Proteins metabolism, Transfection, Matrix Metalloproteinases, Secreted metabolism, Molecular Biology methods, Recombinant Proteins metabolism
Abstract

The expression of a recombinant MMP in a mammalian cell line can be useful, e.g., for purification of the enzyme, to characterize function of the enzyme, or to uncover its substrates. In this chapter, we have therefore documented our experience with the recently discovered MMP-28.

Published
2010
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