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201 results on '"Rodan, A R"'

2. Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster

Author

Mahmoudzadeh, Nader H., Heidarian, Yasaman, Tourigny, Jason P., Fitt, Alexander J., Beebe, Katherine, Li, Hongde, Luhur, Arthur, Buddika, Kasun, Mungcal, Liam, Kundu, Anirban, Policastro, Robert A., Brinkley, Garrett J., Zentner, Gabriel E., Nemkov, Travis, Pepin, Robert, Chawla, Geetanjali, Sudarshan, Sunil, Rodan, Aylin R., D'Alessandro, Angelo, and Tennessen, Jason M.

Published
2024
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3. WNK kinases sense molecular crowding and rescue cell volume via phase separation

Author

Boyd-Shiwarski, Cary R., Shiwarski, Daniel J., Griffiths, Shawn E., Beacham, Rebecca T., Norrell, Logan, Morrison, Daryl E., Wang, Jun, Mann, Jacob, Tennant, William, Anderson, Eric N., Franks, Jonathan, Calderon, Michael, Connolly, Kelly A., Cheema, Muhammad Umar, Weaver, Claire J., Nkashama, Lubika J., Weckerly, Claire C., Querry, Katherine E., Pandey, Udai Bhan, Donnelly, Christopher J., Sun, Dandan, Rodan, Aylin R., and Subramanya, Arohan R.

Published
2022
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5. Author Correction: Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Author

Balderas, Enrique, Eberhardt, David R., Lee, Sandra, Pleinis, John M., Sommakia, Salah, Balynas, Anthony M., Yin, Xue, Parker, Mitchell C., Maguire, Colin T., Cho, Scott, Szulik, Marta W., Bakhtina, Anna, Bia, Ryan D., Friederich, Marisa W., Locke, Timothy M., Van Hove, Johan L. K., Drakos, Stavros G., Sancak, Yasemin, Tristani-Firouzi, Martin, Franklin, Sarah, Rodan, Aylin R., and Chaudhuri, Dipayan

Published
2022
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6. Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Author

Balderas, Enrique, Eberhardt, David R., Lee, Sandra, Pleinis, John M., Sommakia, Salah, Balynas, Anthony M., Yin, Xue, Parker, Mitchell C., Maguire, Colin T., Cho, Scott, Szulik, Marta W., Bakhtina, Anna, Bia, Ryan D., Friederich, Marisa W., Locke, Timothy M., Van Hove, Johan L. K., Drakos, Stavros G., Sancak, Yasemin, Tristani-Firouzi, Martin, Franklin, Sarah, Rodan, Aylin R., and Chaudhuri, Dipayan

Published
2022
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8. Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study

Author

Agarwal, Adhish, primary, Beddhu, Srinivasan, additional, Boucher, Robert, additional, Rao, Veena, additional, Ramkumar, Nirupama, additional, Rodan, Aylin R., additional, Fang, Jacob, additional, Wynne, Brandi M., additional, Drakos, Stavros G., additional, Hanff, Thomas, additional, Cheung, Alfred K., additional, and Fang, James C., additional

Published
2024
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12. Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes

Author

Chvilicek, Maggie M., primary, Seguin, Alexandra, additional, Lathen, Daniel R., additional, Titos, Iris, additional, Cummins‐Beebee, Pearl N., additional, Pabon, Miguel A., additional, Miščević, Maša, additional, Nickel, Emily, additional, Merrill, Collin B., additional, Rodan, Aylin R., additional, and Rothenfluh, Adrian, additional

Published
2024
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13. Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

Author

Mahajan, Anubha, Rodan, Aylin R, Le, Thu H, Gaulton, Kyle J, Haessler, Jeffrey, Stilp, Adrienne M, Kamatani, Yoichiro, Zhu, Gu, Sofer, Tamar, Puri, Sanjana, Schellinger, Jeffrey N, Chu, Pei-Lun, Cechova, Sylvia, van Zuydam, Natalie, Consortium, the SUMMIT, Project, the BioBank Japan, Arnlov, Johan, Flessner, Michael F, Giedraitis, Vilmantas, Heath, Andrew C, Kubo, Michiaki, Larsson, Anders, Lindgren, Cecilia M, Madden, Pamela AF, Montgomery, Grant W, Papanicolaou, George J, Reiner, Alex P, Sundström, Johan, Thornton, Timothy A, Lind, Lars, Ingelsson, Erik, Cai, Jianwen, Martin, Nicholas G, Kooperberg, Charles, Matsuda, Koichi, Whitfield, John B, Okada, Yukinori, Laurie, Cathy C, Morris, Andrew P, and Franceschini, Nora

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Kidney Disease, Biotechnology, Human Genome, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Renal and urogenital, Alleles, Animals, Deoxyribonuclease I, Diabetes Mellitus, Disease Models, Animal, Drosophila melanogaster, Ethnicity, Female, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Linkage Disequilibrium, Male, NFATC Transcription Factors, Polymorphism, Single Nucleotide, Quantitative Trait Loci, RGS Proteins, Racial Groups, Renal Insufficiency, Chronic, Salt Tolerance, Sodium Chloride, Sodium-Phosphate Cotransporter Proteins, Type IIa, Stress, Physiological, SUMMIT Consortium, BioBank Japan Project, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p < 5 × 10(-8)) with kidney function and highlighted that allelic effects on eGFR at lead SNPs are homogeneous across ancestries. We leveraged differences in the pattern of linkage disequilibrium between diverse populations to fine-map the 20 loci through construction of "credible sets" of variants driving eGFR association signals. Credible variants at the 20 eGFR loci were enriched for DNase I hypersensitivity sites (DHSs) in human kidney cells. DHS credible variants were expression quantitative trait loci for NFATC1 and RGS14 (at the SLC34A1 locus) in multiple tissues. Loss-of-function mutations in ancestral orthologs of both genes in Drosophila melanogaster were associated with altered sensitivity to salt stress. Renal mRNA expression of Nfatc1 and Rgs14 in a salt-sensitive mouse model was also reduced after exposure to a high-salt diet or induced CKD. Our study (1) demonstrates the utility of trans-ethnic fine mapping through integration of GWASs involving diverse populations with genomic annotation from relevant tissues to define molecular mechanisms by which association signals exert their effect and (2) suggests that salt sensitivity might be an important marker for biological processes that affect kidney function and CKD in humans.

Published
2016

15. Unanticipated domain requirements for Drosophila Wnk kinase in vivo

Author

Yarikipati, Prathibha, primary, Jonusaite, Sima, additional, Pleinis, John M., additional, Dominicci Cotto, Carihann, additional, Sanchez-Hernandez, David, additional, Morrison, Daryl E., additional, Goyal, Suhani, additional, Schellinger, Jeffery, additional, Pénalva, Clothilde, additional, Curtiss, Jennifer, additional, Rodan, Aylin R., additional, and Jenny, Andreas, additional

Published
2023
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16. Large genetic analysis of alcohol resistance and tolerance reveals an inverse correlation and suggests "true" tolerance mutants.

Author

Chvilicek, Maggie M, primary, Seguin, Alexandra, additional, Lathen, Daniel R, additional, Titos, Iris, additional, Cummins-Beebe, Pearl N, additional, Pabon, Miguel A, additional, Miscevic, Masa, additional, Nickel, Emily A, additional, Merrill, Collin B, additional, Rodan, Aylin R, additional, and Rothenfluh, Adrian, additional

Published
2023
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17. Hydrostatic Pressure Sensing by WNK kinases

Author

Humphreys, John M., primary, Teixeira, Liliana R., additional, Akella, Radha, additional, He, Haixia, additional, Kannangara, Ashari R., additional, Sekulski, Kamil, additional, Pleinis, John, additional, Liwocha, Joanna, additional, Jiou, Jenny, additional, Servage, Kelly A., additional, Orth, Kim, additional, Joachimiak, Lukasz, additional, Rizo, Josep, additional, Cobb, Melanie H., additional, Brautigam, Chad A., additional, Rodan, Aylin R., additional, and Goldsmith, Elizabeth J., additional

Published
2023
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23. Potassium: friend or foe?

Author

Rodan, Aylin R.

Subjects
Mortality -- Analysis, Potassium channels -- Health aspects, Hyperkalemia -- Patient outcomes -- Complications and side effects, Health
Abstract

The kidney plays an essential role in maintaining homeostasis of ion concentrations in the blood. Because the concentration gradient of potassium across the cell membrane is a key determinant of the membrane potential of cells, even small deviations in serum potassium level from the normal setpoint can lead to severe muscle dysfunction, resulting in respiratory failure and cardiac arrest. Less severe hypo- and hyperkalemia are also associated with morbidity and mortality across various patient populations. In addition, deficiencies in potassium intake have been associated with hypertension and adverse cardiovascular and renal outcomes, likely due in part to the interrelated handling of sodium and potassium by the kidney. Here, data on the beneficial effects of potassium on blood pressure and cardiovascular and renal outcomes will be reviewed, along with the physiological basis for these effects. In some patient populations, however, potassium excess is deleterious. Risk factors for the development of hyperkalemia will be reviewed, as well as the risks and benefits of existing and emerging therapies for hyperkalemia., Author(s): Aylin R. Rodan [sup.1] Author Affiliations: (1) 0000 0000 9482 7121grid.267313.2Department of Internal Medicine, University of Texas Southwestern Medical Center, 75390-8856, Dallas, TX, USA Introduction Both hypokalemia and hyperkalemia [...]

Published
2017
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24. Rsu1 regulates ethanol consumption in Drosophila and humans

Author

The IMAGEN Consortium, Ojelade, Shamsideen A., Jia, Tianye, Rodan, Aylin R., Chenyang, Tao, Kadrmas, Julie L., Cattrell, Anna, Ruggeri, Barbara, Charoen, Pimphen, Lemaitre, Hervé, Banaschewski, Tobias, Büchel, Christian, Bokde, Arun L. W., Carvalho, Fabiana, Conrod, Patricia J., Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lubbe, Steven, Martinot, Jean-Luc, Paus, Tomás, Smolka, Michael N., Spanagel, Rainer, O’Reilly, Paul F., Laitinen, Jaana, Veijolaa, Juha M., Feng, Jianfeng, Desrivières, Sylvane, Jarvelin, Marjo-Riitta, Schumann, Gunter, and Rothenfluh, Adrian

Published
2015

25. Megalin as a Metabolic Modulator in the Kidney and Beyond.

Author

Nicholson, Rebekah J, Ramkumar, Nirupama, and Rodan, Aylin R

Subjects
HIGH-carbohydrate diet, WESTERN diet, PROXIMAL kidney tubules, KIDNEY tubules, GENE expression, ENDOCYTOSIS
Abstract

The article "Megalin as a Metabolic Modulator in the Kidney and Beyond" explores the role of megalin, a protein found in the kidney, in regulating metabolism and kidney function. The study conducted on mice suggests that megalin has a complex role in kidney disease and systemic metabolism. Knockout mice exhibited improved glucose tolerance and resistance to weight gain on a Western diet, but also suffered from kidney fibrosis and inflammation. The study emphasizes the need for further research into megalin's function and its potential implications for metabolic conditions. The article is distributed under the Creative Commons Attribution-NonCommercial License, allowing for non-commercial reuse, distribution, and reproduction with proper citation. Commercial reuse requires permission from the journal. [Extracted from the article]

Published
2024
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35. WNK kinases sense molecular crowding and rescue cell volume via phase separation

Author

Boyd-Shiwarski, Cary R., primary, Shiwarski, Daniel J., additional, Griffiths, Shawn E., additional, Beacham, Rebecca T., additional, Norrell, Logan, additional, Morrison, Daryl E., additional, Wang, Jun, additional, Mann, Jacob, additional, Tennant, William, additional, Anderson, Eric N., additional, Franks, Jonathan, additional, Calderon, Michael, additional, Connolly, Kelly A., additional, Weaver, Claire J., additional, Weckerly, Claire C., additional, Pandey, Udai Bhan, additional, Donnelly, Christopher J., additional, Sun, Dandan, additional, Rodan, Aylin R., additional, and Subramanya, Arohan R., additional

Published
2022
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39. Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy

Author

Al-Rabadi, Laith Farah, primary, Caza, Tiffany, additional, Trivin-Avillach, Claire, additional, Rodan, Aylin R., additional, Andeen, Nicole, additional, Hayashi, Norifumi, additional, Williams, Brandi, additional, Revelo, Monica P., additional, Clayton, Fred, additional, Abraham, Jo, additional, Lin, Edwin, additional, Liou, Willisa, additional, Zou, Chang-Jiang, additional, Ramkumar, Nirupama, additional, Cummins, Tim, additional, Wilkey, Daniel W., additional, Kawalit, Issa, additional, Herzog, Christian, additional, Storey, Aaron, additional, Edmondson, Rick, additional, Sjoberg, Ronald, additional, Yang, Tianxin, additional, Chien, Jeremy, additional, Merchant, Michael, additional, Arthur, John, additional, Klein, Jon, additional, Larsen, Chris, additional, and Beck, Laurence H., additional

Published
2021
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41. Additional file 1 of The fly liquid-food electroshock assay (FLEA) suggests opposite roles for neuropeptide F in avoidance of bitterness and shock

Author

Puskar Mishra, Shany E. Yang, Montgomery, Austin B., Reed, Addison R., Rodan, Aylin R., and Rothenfluh, Adrian

Abstract

Additional file 1: Fig S1. Frequency plot of inter-event intervals from the FLIC (related to Fig. 1d). We chose 5 s, the inflection point of this distribution, to group events together, or apart.

Published
2021
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42. Additional file 2 of The fly liquid-food electroshock assay (FLEA) suggests opposite roles for neuropeptide F in avoidance of bitterness and shock

Author

Puskar Mishra, Shany E. Yang, Montgomery, Austin B., Reed, Addison R., Rodan, Aylin R., and Rothenfluh, Adrian

Abstract

Additional file 2: Fig S2. FLEA schematics: (Top left) FLEA setup, with board on top, exchangeable resistor module on bottom right, and general setup on the bottom left. The circuit diagrams for the resistor module (top, right) and FLEA board (bottom, front and back of board) are show.

Published
2021
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43. Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy

Author

Al-Rabadi, Laith Farah, Caza, Tiffany, Trivin-Avillach, Claire, Rodan, Aylin R., Andeen, Nicole, Hayashi, Norifumi, Williams, Brandi, Revelo, Monica P., Clayton, Fred, Abraham, Jo, Lin, Edwin, Liou, Willisa, Zou, Chang-Jiang, Ramkumar, Nirupama, Cummins, Tim, Wilkey, Daniel W., Kawalit, Issa, Herzog, Christian, Storey, Aaron, Edmondson, Rick, Sjöberg, Ronald, Yang, Tianxin, Chien, Jeremy, Merchant, Michael, Arthur, John, Klein, Jon, Larsen, Chris, Beck, Laurence H., Al-Rabadi, Laith Farah, Caza, Tiffany, Trivin-Avillach, Claire, Rodan, Aylin R., Andeen, Nicole, Hayashi, Norifumi, Williams, Brandi, Revelo, Monica P., Clayton, Fred, Abraham, Jo, Lin, Edwin, Liou, Willisa, Zou, Chang-Jiang, Ramkumar, Nirupama, Cummins, Tim, Wilkey, Daniel W., Kawalit, Issa, Herzog, Christian, Storey, Aaron, Edmondson, Rick, Sjöberg, Ronald, Yang, Tianxin, Chien, Jeremy, Merchant, Michael, Arthur, John, Klein, Jon, Larsen, Chris, and Beck, Laurence H.

Abstract

Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B can explain the majority of cases of primary membranous nephropathy (MN). However, target antigens remain unidentified in 15%-20% of patients. Methods A multipronged approach, using traditional and modern technologies, converged on a novel target antigen, and capitalized on the temporal variation in autoantibody titer for biomarker discovery. Immunoblotting of human glomerular proteins followed by differential immunoprecipitation and mass spectrometric analysis was complemented by laser-capture microdissection followed by mass spectrometry, elution of immune complexes from renal biopsy specimen tissue, and autoimmune profiling on a protein fragment microarray. Results These approaches identified serine protease HTRA1 as a novel podocyte antigen in a subset of patients with primary MN. Sera from two patients reacted by immunoblotting with a 51-kD protein within glomerular extract and with recombinant human HTRA1, under reducing and nonreducing conditions. Longitudinal serum samples from these patients seemed to correlate with clinical disease activity. As in PLA2R- and THSD7A- associated MN, anti-HTRA1 antibodies were predominantly IgG4, suggesting a primary etiology. Analysis of sera collected during active disease versus remission on protein fragment microarrays detected significantly higher titers of anti-HTRA1 antibody in active disease. HTRA1 was specifically detected within immune deposits of HTRA1-associated MN in 14 patients identified among three cohorts. Screening of 118 "quadruple-negative" (PLA2R-, THSD7A-, NELL1-, EXT2-negative) patients in a large repository of MN biopsy specimens revealed a prevalence of 4.2%. Conclusions Conventional and more modern techniques converged to identify serine protease HTRA1 as a target antigen in MN., QC 20220224

Published
2021
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47. WNKs are potassium-sensitive kinases

Author

Pleinis, John M., primary, Norrell, Logan, additional, Akella, Radha, additional, Humphreys, John M., additional, He, Haixia, additional, Sun, Qifei, additional, Zhang, Feng, additional, Sosa-Pagan, Jason, additional, Morrison, Daryl E., additional, Schellinger, Jeffrey N., additional, Jackson, Laurie K., additional, Goldsmith, Elizabeth J., additional, and Rodan, Aylin R., additional

Published
2021
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48. A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

Author

Talsness, Dana M, primary, Owings, Katie G, additional, Coelho, Emily, additional, Mercenne, Gaelle, additional, Pleinis, John M, additional, Partha, Raghavendran, additional, Hope, Kevin A, additional, Zuberi, Aamir R, additional, Clark, Nathan L, additional, Lutz, Cathleen M, additional, Rodan, Aylin R, additional, and Chow, Clement Y, additional

Published
2020
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50. Drosophila fasciclinll is required for the formation of odor memories and for normal sensitivity to alcohol

Author

Cheng, Yuzhong, Endo, Keita, Wu, Kwok, Rodan, Aylin R., Heberlein, Ulrike, and Davis, Ronald L.

Subjects
Cell research -- Analysis, Drosophila -- Physiological aspects, Alcohols -- Physiological aspects, Odors -- Physiological aspects, Biological sciences
Abstract

Research has been conducted on the Drosophila fasciclinll (fasII) mutants exhibiting strong sensitivity to the ethanol vapors. The role of FasII in the molecular operations of the encoding short-term odor memories and conferring alcohol sensitivity has been investigated via the use of the behavioral and genetic strategies and the details are presented.

Published
2001

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