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31 results on '"Rock, Colleen"'

1. Semantic Links Across Distributed Heterogeneous Data

Author

Jeter, Sarah, Rock, Colleen, Benyo, Brett, Adler, Aaron, Yaman, Fusun, Beckerle, Michael, Mulvehill, Alice, Hoh, Robert, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Herrera, Francisco, editor, Matsui, Kenji, editor, and Rodríguez-González, Sara, editor

Published
2020
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4. Supplemental Figure 5 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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5. Supplemental Figure 2 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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6. Supplemental Figure 3 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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7. Supplemental Figure 1 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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8. Supplemental Figure 7 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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9. Supplemental Figure 4 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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10. Supplemental Figure 6 from Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, primary, Billings, Steven D., primary, Thomson, Brian J., primary, Tang, Jean Y., primary, Sarin, Kavita Y., primary, Cai, Emily, primary, Kim, Jinah, primary, Rock, Colleen, primary, Kimbrell, Hillary Z., primary, Flake, Darl D., primary, Warf, M. Bryan, primary, Nelson, Jonathan, primary, Davis, Thaylon, primary, Miller, Catherine, primary, Rushton, Kristen, primary, Hartman, Anne-Renee, primary, Wenstrup, Richard J., primary, and Clarke, Loren E., primary

Published
2023
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16. Mission-Centric Content Sharing Across Heterogeneous Networks

Author

Strayer, Tim, primary, Ramanathan, Ram, additional, Coffin, Daniel, additional, Nelson, Samuel, additional, Atighetchi, Michael, additional, Adler, Aaron, additional, Blais, Stephane, additional, Thapa, Bishal, additional, Tetteh, Will, additional, Shurbanov, Vlad, additional, Haigh, Karen, additional, Hain, Regina, additional, Rock, Colleen, additional, Do, Emily, additional, Caro, Armando, additional, Ellard, Daniel, additional, Beckerle, Michael, additional, Lawrence, Stephen, additional, and Loos, Scott, additional

Published
2019
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17. Examining key mobility resources through denial of service attacks on proposed global name resolution services

Author

Karen R. Sollins., Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science., Rock, Colleen T, Karen R. Sollins., Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science., and Rock, Colleen T

Abstract

Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016., This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections., Cataloged from student-submitted PDF version of thesis., Includes bibliographical references (pages 66-68)., The problem we address in this thesis is to uncover the design elements in a network architecture design that may open it up to denial of service (DoS) attacks and to expose the tradeoffs in mitigating those DoS opportunities. We take as our candidate network architecture design the Future Internet Architecture project MobilityFirst. MobilityFirst's overarching goal, driven by increasingly available wireless communication, is the support of mobility in an Internet architecture. At its core, MobilityFirst separates identification from location, as distinct from the current Internet architecture, and postulates the existence of globally unique, flat identifiers. In order to support mobility in this context, it also postulates a global name resolution service (GNRS). In this thesis we examine three alternative designs for the GNRS and the opportunities they expose for DoS attacks. We consider each one in depth analytically. As an example, we then study one particular attack in depth and are forced to conclude that approaches to mitigating this attack would have significant negative impact on the support of mobility thus exposing the dilemma in such system design tradeoffs., by Colleen T. Rock., M. Eng.

Published
2018

20. Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Author

Ko, Jennifer S., primary, Matharoo-Ball, Balwir, additional, Billings, Steven D., additional, Thomson, Brian J., additional, Tang, Jean Y., additional, Sarin, Kavita Y., additional, Cai, Emily, additional, Kim, Jinah, additional, Rock, Colleen, additional, Kimbrell, Hillary Z., additional, Flake, Darl D., additional, Warf, M. Bryan, additional, Nelson, Jonathan, additional, Davis, Thaylon, additional, Miller, Catherine, additional, Rushton, Kristen, additional, Hartman, Anne-Renee, additional, Wenstrup, Richard J., additional, and Clarke, Loren E., additional

Published
2017
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22. Examining Key Mobility Resources through Denial of Service Attacks on proposed Global Name Resolution Services

Author

Karen Sollins, Advanced Network Architecture, Rock, Colleen T., Karen Sollins, Advanced Network Architecture, and Rock, Colleen T.

Abstract

MEng thesis, The problem we address in this thesis is to uncover the design elements in a network architecture design that may open it up to denial of service (DoS) attacks and to expose the tradeoffs in mitigating those DoS opportunities. We take as our candidate network architecture design the Future Internet Architecture project MobilityFirst. MobilityFirst's overarching goal, driven by increasingly available wireless communication, is the support of mobility in an Internet architecture. At its core, MobilityFirst separates identification from location, as distinct from the current Internet architecture, and postulates the existence of globally unique, flat identifiers. In order to support mobility in this context, it also postulates a global name resolution service (GNRS). In this thesis we examine three alternative designs for the GNRS and the opportunities they expose for DoS attacks. We consider each one in depth analytically. As an example, we then study one particular attack in depth and are forced to conclude that approaches to mitigating this attack would have significant negative impact on the support of mobility thus exposing the dilemma in such system design tradeoffs.

Published
2016

25. Understanding the Genetic Regulation and Function of Selenoprotein P

Author

Rock, Colleen Marie

Subjects
integumentary system, Selenoproteins
Abstract

Selenium is an essential trace element that has been linked to beneficial health effects in multiple disease states. These effects have been attributed to antioxidant activity of selenoproteins; proteins containing selenium incorporated as the amino acid selenocysteine during translation of the protein. Selenoprotein P is an extracellular glycoprotein containing multiple selenocysteine residues. It is the primary selenium distribution protein of the body as well as the major selenium containing protein in serum. An antioxidant function has been observed for this protein. The experiments presented in this dissertation were designed to further characterize the mechanisms of selenoprotein P regulation and function and test the hypothesis that mechanisms regulating the expression of selenoprotein P provide for modulation of this protein so it may function to provide antioxidant protection in extrahepatic tissues. When stimulated with ecdysone analogs, selenoprotein P expression was increased with the use of a fusion transcription factor that contains the glucocorticoid receptor DNA binding domain, an ecdysone ligand-binding domain, and a strong transactivation domain as well as the retinoid X receptor. In silico analysis of the selenoprotein P promoter identified putative glucocorticoid and retinoid responsive binding sites. Luciferase reporter assays and quantitative PCR were used to measure selenoprotein P transcription in engineered HEK-293 cells. The native glucocorticoid receptor inhibited selenoprotein P transactivation, and selenoprotein P was further attenuated in the presence of dexamethasone. These studies also aimed to determine if selenoprotein P possessed hydroperoxidase activity against lipid hydroperoxides generated from the metabolism of arachidonic acid by 15-lipoxygenase-1. Enzymatic reduction of 15- hydroperoxyeicosatetraenoic acid (15-HpETE) by selenoprotein P was observed in a NADPH-coupled biochemical assay. Diphenylpyrenylphosphin was used to measure lipid hydroperoxides in human embryonic kidney cells treated with selenoprotein P following exposure to 15-HpETE. Cellular oxidation increased with 15-HpETE treatment and selenoprotein P reduced this effect. These results suggest that selenoprotein P can function as an antioxidant enzyme during inflammation. An increased understanding of the mechanisms regulating selenoprotein P expression and activity could provide insight into the way in which selenium exerts its physiological effects.

Published
2012
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27. Development and validation of a gene expression signature to distinguish malignant melanoma from benign nevi.

Author

Rock, Colleen, primary, Clarke, Loren E, additional, Warf, M. Bryan, additional, Flake, Darl D, additional, Hartman, Anne-Renee, additional, Tahan, Steven, additional, Shea, Christopher R, additional, Gerami, Pedram, additional, Messina, Jane, additional, Wenstrup, Richard J., additional, Rushton, Kristen, additional, Roundy, Kirstin M, additional, Roa, Benjamin, additional, Kolquist, Kathryn A, additional, Gutin, Alexander, additional, Billings, Steven D, additional, and Leachman, Sancy Ann, additional

Published
2014
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28. Tu1019 A Prospective Evaluation of the Feasibility of Process Engineering Intervention on the Screening and Testing of Lynch Syndrome in Individuals With a Personal and/or Family History of Lynch-Associated Cancers

Author

DiSario, James A., primary, Luba, Daniel G., additional, Rock, Colleen, additional, Saraiya, Devki, additional, Moyes, Kelsey, additional, Rushton, Kristen, additional, Ogara, Maydeen M., additional, Zimmerman, Dayna, additional, Raphael, Mona, additional, Garrido, Kimmie, additional, Silguero, Evelyn, additional, Nelson, Jonathan, additional, Abbott, Brian L., additional, Kastrinos, Fay, additional, Wenstrup, Richard J., additional, and Syngal, Sapna, additional

Published
2014
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