263 results on '"Roche, Brian"'
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2. Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As
3. The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis
4. Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute
5. Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation
6. Large-Scale Performance Evaluation of Various Woven Silt Fence Installations under Nebraska Highway Conditions
7. Integration of cardiac energetics, function and histology from isolated rat hearts perfused with doxorubicin and doxorubicin-ol; a model for use in drug safety evaluations
8. The “One‐Step” approach for QT analysis increases the sensitivity of nonclinical QTc analysis
9. Efficacy of Undisturbed Vegetated Buffers in Capturing Suspended Sediment
10. Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies
11. Effects of tyrosine kinase inhibitors on rat isolated heart function and protein biomarkers indicative of toxicity
12. A comparison of multiple left ventricular pressure endpoints as a screening tool in rats
13. Visualizing QT prolongation in the anesthetized guinea pig
14. Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: Effects of early versus delayed treatment
15. Large intestine motility in the rodent—How does it measure up?
16. Is enough, enough? SEND data processing considerations when changing the logging rate
17. A cardiovascular assessment following a single oral (gavage) dose of digoxin and verapamil in conscious, dual pressure radiotelemetry-instrumented male Sprague-Dawley rats
18. An evaluation and comparison of vessel reactivity using the descending aorta and superior mesenteric artery in a myograph system
19. Power spectral density analysis of heart beat intervals in the Guinea pig
20. Assessment of multiple positive controls in the Langendorff isolated heart assay and how they translate to whole animal
21. Can cardiovascular liabilities be detected earlier in drug development? Assessing the translation of tyrosine kinase inhibitors from cardiomyocytes and isolated hearts to whole animal
22. Is the current non-clinical drug development safety paradigm effective for assessing cardiovascular liabilities?
23. Closing the gap preclinically to derisk the potential for serotonin toxicity: Was that a twitch I see?
24. Surface lead EEGs: Will it stick?
25. Relationship between prolongation of QTc and prolongation of the peak of T (Tp) to the end of T (Te)
26. Use of a Failing Rabbit Heart as a Model to Predict Torsadogenicity
27. Tale of Two Florida Cities-Competition and Innovation Drive Biosolids Management toward the Private Sector
28. Data strength assessment of the social-housed modified Irwin test when performed concurrently with a CNS tetrad evaluation
29. Gastrointestinal motility assessment comparing two species (rat vs. mouse)
30. A comprehensive evaluation of four antineoplastic agents in the Langendorff isolated heart assay
31. Applications and direct comparisons of EEG collection methodologies in nonclinical studies
32. Assessing the impact and translation from the effects of three tyrosine kinase inhibitors from a single cardiac cell to the whole heart
33. WWW3 Deliver a $1 Billion CIP, Reduce Debt by $250 Million, and Transfer $1/4 Billion to the City
34. Tale of Two Florida Cities - Competition and Innovation Drive Biosolids Management toward the Private Sector
35. The Assessment of Subcutaneous Lead vs. Implanted Lead Electroencephalography and Electromyography
36. Are All Respiratory Chambers Created Equal? A Comparative Assessment Between Allay Restraint and Standard Head Out Plethysmography
37. The Effects of Phenylephrine and Diltiazem on Cardiovascular Function in Anesthetized and Conscious Beagle Dogs: Considerations for Estimating Pulmonary Artery Pressure from Right Ventricular Pressure
38. The Cardiac Sensitization Test: The Evaluation of Propofol in Dogs to Mitigate the Expected Convulsant Activity of a Typical Liquid Halogenated Olefin
39. Assessing the Arrhythmogenic Liabilities of Moxifloxacin and Dofetilide
40. Secrets Of The Computer Hard Drive
41. Left ventricular pressure may improve predictivity of preclinical cardiovascular assays to clinical outcomes
42. Cloud analysis of rat cardiac contractility: Determining changes in left ventricular dP/dt without correcting for heart rate
43. PK and cardiac assessment in rats administered doxorubicin
44. Neurobehavioral and Cardiovascular Effects of Potassium Cyanide Administered Orally to Mice
45. We've grown up.
46. Thinking through head transplants
47. The homework wars
48. Acute effects of doxorubicin and its primary metabolite doxorubicin-ol on the isolated heart
49. Effects of tyrosine kinase inhibitors on rat isolated heart function and protein biomarkers indicative of toxicity
50. Simulated metabolism in the Langendorff: Determining and characterizing novel dose solutions for 5-fluorouracil and doxorubicin
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