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504 results on '"Rocha, Natalia A."'

1. The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol

Author

Chahine, Lana M., Louie, Naomi, Solle, J, Akçimen, Fulya, Ameri, Andrew, Augenbraun, Samantha, Avripas, Sabrina, Breaux, Sarah, Causey, Christopher, Chandra, Shivika, Dean, Marissa, Disbrow, Elizabeth A., Fanty, Lauren, Fernandez, Jessica, Foster, Erin R., Furr Stimming, Erin, Hall, Deborah, Hinson, Vanessa, Johnson-Turbes, Ashani, Jonas, Cabell, Kilbane, Camilla, Norris, Scott A., Nguyen, Bao-Tran, Padmanaban, Mahesh, Paquette, Kimberly, Parry, Carly, Pessoa Rocha, Natalia, Rawls, Ashley, Shamim, Ejaz A., Shulman, Lisa M., Sipma, Rebeka, Staisch, Julia, Traurig, Rami, von Coelln, Rainer, Wild Crea, Peter, Xie, Tao, Fang, Zih-Hua, O’Grady, Alyssa, Kopil, Catherine M., McGuire Kuhl, Maggie, Singleton, Andrew, Blauwendraat, Cornelis, and Bandres-Ciga, Sara

Published
2024
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2. Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study.

Author

Toscano, Eliana, Vieira, Érica, Rocha, Natalia, Brant, Joseane, Paradela, Regina, Giannetti, Alexandre, Suemoto, Claudia, Leite, Renata, Nitrini, Ricardo, Rachid, Milene, Teixeira, Antonio, and Grinberg, Lea

Subjects
Cognition, Drug-resistant epilepsy, Neurodegeneration, p-tau, Adult, Humans, Middle Aged, Epilepsy, Temporal Lobe, Amyloid beta-Peptides, Hippocampus, Seizures, Drug Resistant Epilepsy, Cognition
Abstract

Temporal lobe epilepsy (TLE) often courses with cognitive deficits, but its underlying neuronal basis remains unclear. Confluent data suggest that epilepsy share pathophysiological mechanisms with neurodegenerative diseases. However, as most studies analyze subjects 60 years old and older, it is challenging to rule out that neurodegenerative changes arise from age-related mechanisms rather than epilepsy in these individuals. To fill this gap, we conducted a neuropathological investigation of the hippocampal formation of 22 adults with mesial TLE and 20 age- and sex-matched controls (both younger than 60 years). Moreover, we interrogated the relationship between these neuropathological metrics and cognitive performance. Hippocampal formation extracted from patients with drug-resistant mesial TLE undergoing surgery and postmortem non-sclerotic hippocampal formation of clinically and neuropathologically controls underwent immunohistochemistry against amyloid β (Aβ), hyperphosphorylated tau (p-tau), and TAR DNA-binding protein-43 (TDP-43) proteins, followed by quantitative analysis. Patients underwent a comprehensive neuropsychological evaluation prior to surgery. TLE hippocampi showed a significantly higher burden of p-tau than controls, whereas Aβ deposits and abnormal inclusions of TDP-43 were absent in both groups. Patients with hippocampal sclerosis (HS) type 2 had higher immunostaining for p-tau than patients with HS type 1. In addition, p-tau burden was associated with impairment in attention tasks and seizures frequency. In this series of adults younger than 60 years-old, the increase of p-tau burden associated with higher frequency of seizures and attention impairment suggests the involvement of tau pathology as a potential contributor to cognitive deficits in mesial TLE.

Published
2023

8. Nigrostriatal Inflammation Is Associated with Nonmotor Symptoms in an Experimental Model of Prodromal Parkinson’s Disease

Author

Oliveira, Bruna da Silva, Toscano, Eliana Cristina de Brito, Abreu, Larissa Katharina Sabino, Fernandes, Heliana de Barros, Amorim, Renan Florindo, Ferreira, Rodrigo Novaes, Machado, Caroline Amaral, Carvalho, Brener Cunha, da Silva, Maria Carolina Machado, de Oliveira, Antônio Carlos Pinheiro, Rachid, Milene Alvarenga, Rocha, Natália Pessoa, Teixeira, Antônio Lúcio, da Silva, Elizabeth Ribeiro, and de Miranda, Aline Silva

Published
2024
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12. Potential Biomarkers of impulsivity in mild traumatic brain injury: A pilot study

Author

Cardoso, Maíra Glória de Freitas, de Barros, João Luís Vieira Monteiro, de Queiroz, Rafael Alves Bonfim, Rocha, Natalia Pessoa, Silver, Carlisa, da Silva, Agnes Stéphanie, da Silva, Ewelin Wasner Machado, Roque, Isadora Gonçalves, Carvalho, Júlia de Lima, dos Santos, Laura Ferreira, Cota, Letícia Bitencourt, Lemos, Lucas Miranda, Miranda, Mariana Figueiredo, Miranda, Millena Figueiredo, Vianna, Pedro Parenti, Oliveira, Rafael Arantes, de Oliveira Furlam, Tiago, Soares, Túlio Safar Sarquis, Pedroso, Vinicius Sousa Pietra, Faleiro, Rodrigo Moreira, Vieira, Érica Leandro Marciano, Teixeira, Antônio Lúcio, de Souza, Leonardo Cruz, and de Miranda, Aline Silva

Published
2023
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14. Huntington’s Disease

Author

Rocha, Natalia Pessoa, additional, Liu, Andy, additional, Anderson, Karen, additional, and Furr Stimming, Erin, additional

Published
2022
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27. Neuroimmunoendocrinology

Author

Rocha, Natalia P., Bauer, Moises E., Teixeira, Antonio L., Parnham, Michael J., editor, Nijkamp, Frans P., editor, and Rossi, Adriano G., editor

Published
2019
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30. Estratégias para prevenir a síndrome compartimental abdominal em pacientes com trauma abdominal

Author

Borges, Sarah Silvestre, primary, Silveira, Igor Boechat Magalhães da, additional, Watanabe, Enzo Tatsumi, additional, Carvalho, Clara de Souza, additional, Rocha, Natalia Daudt Eickstaedt, additional, Soletti, Carolina, additional, Costa, Thaís Roveta, additional, Vieira, Bárbara Magalhães, additional, Pranstete, Milena Stocco, additional, and Sacramento, Neidejany de Assunção do, additional

Published
2024
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31. Hyperaemia during dynamic handgrip exercise is preserved in healthy young subjects after recovery from COVID‐19.

Author

Prodel, Eliza, Souza, Roberto, Divino, Beatriz, Rocha, Helena N. M., Rocha, Natalia G., and Nobrega, Antonio C. L.

Abstract

We sought to investigate possible impaired hyperaemia during dynamic handgrip exercise (HGE) in young healthy individuals who had recovered from COVID‐19. We tested the vascular function in individuals recovered from COVID‐19 using a nitric oxide donor (i.e., sodium nitroprusside; SNP), which could revert a possible impaired endothelial function during HGE. Further, we tested whether individuals who recovered from COVID‐19 would present exaggerated brachial vascular resistance under an adrenergic agonist (i.e., phenylephrine; PHE) stimuli during HGE. Participants were distributed into two groups: healthy controls (Control; men: n = 6, 30 ± 3 years, 26 ± 1 kg/m2; and women: n = 5, 25 ± 1 years, 25 ± 1 kg/m2) and subjects recovered from COVID‐19 (post‐COVID; men: n = 6, 29 ± 3 years, 25 ± 1 kg/m2; and women: n = 10, 32 ± 4 years, 22 ± 1 kg/m2). Participants in the post‐COVID group tested positive (RT‐PCR) 12–14 weeks before the protocol. Heart rate (HR), brachial blood pressure (BP), brachial blood flow (BBF) and vascular conductance (BVC) at rest were not different between groups. The HGE increased HR (Control: Δ9 ± 0.4 bpm; and post‐COVID: Δ11 ± 0.4 bpm) and BP (Control: Δ6 ± 1 mmHg; and post‐COVID: Δ12 ± 0.6 mmHg) in both groups. Likewise, BBF (Control: Δ632 ± 38 ml/min; and post‐COVID: Δ620 ± 27 ml/min) and BVC (Control: Δ6.6 ± 0.4 ml/min/mmHg; and post‐COVID: Δ6.1 ± 0.3 ml/min/mmHg) increased during HGE. SNP did not change HGE‐induced hyperaemia but did decrease BP, which induced a reflex‐related increase in HR. PHE infusion also did not change the HGE‐induced hyperaemia but raised BP and reduced HR. In conclusion, exercise‐induced hyperaemia is preserved in healthy young subjects 12–14 weeks after recovery from COVID‐19 infection. What is the central question of this study?How does vascular function compare during dynamic handgrip exercise in young healthy adult males and females who recovered from COVID‐19?What is the main finding and its importance?No differences were observed in exercise hyperaemia in healthy young adults, males and females, who recovered from COVID‐19 compared to the healthy control group. Vascular function seems to be preserved in individuals 12–14 weeks after COVID‐19 during dynamic handgrip exercise in young healthy adults, males and females. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Hearts and Minds: Emotion Recognition and Mentalizing in Parkinson's Disease and Progressive Supranuclear Palsy.

Author

Martins, Marina I, Cardoso, Francisco E C, Caramelli, Paulo, Mariano, Luciano I, Rocha, Natalia P, Jaeger, Antônio, Teixeira, Antônio L, Tumas, Vítor, Camargos, Sarah T, and Souza, Leonardo C de

Subjects
PROGRESSIVE supranuclear palsy, PARKINSON'S disease, EMOTION recognition, THEORY of mind, DISEASE progression
Abstract

Objective There are scarce data comparing Parkinson's disease (PD) and Progressive Supranuclear Palsy (PSP) in social cognition (SC). We aimed to compare patients with PSP and PD in SC. Methods We included three groups: PD (n  = 18), PSP (n  = 20) and controls (n  = 23). Participants underwent neuropsychological exams, including the mini-version of the Social and Emotional Assessment, which is composed of the facial emotion recognition test (FERT) and the modified faux-pas (mFP) test, which assesses Theory of Mind (ToM). Results Patients with PD scored lower than controls in the FERT, but not in the mFP test. Patients with PSP performed worse than controls in both the mFP and FERT. PD and PSP groups did not differ in the FERT, but PSP performed worse than PD in the mFP test. The mFP test distinguished PSP from PD with 89% accuracy. Conclusion The assessment of ToM may contribute to the differentiation between PD and PSP. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15

Author

Yang Fang, Barbosa Izabela G., Vieira Erica L., Bauer Moises E., Rocha Natalia P., and Teixeira Antonio L.

Subjects
bipolar disorder, gdf-15, aging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters.

Published
2018
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50. Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: Evidence for defective immunomodulatory mechanisms

Author

de Campos-Carli, Salvina Maria, Araújo, Marcio Sobreira, de Oliveira Silveira, Amanda Cardoso, de Rezende, Vitor Bortolo, Rocha, Natalia Pessoa, Ferretjans, Rodrigo, Ribeiro-Santos, Rafael, Teixeira-Carvalho, Andrea, Martins-Filho, Olindo Assis, Berk, Michael, Salgado, João Vinícius, and Teixeira, Antonio Lucio

Published
2017
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