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Objective: The aim of this systematic review was to investigate the effect of exercise-based programmes in the prevention of non-contact musculoskeletal injuries among football players in comparison to a control group. Design: Systematic review and meta-analysis of randomised controlled trials. Data sources: MEDLINE, EMBASE, CENTRAL, CINAHL, PEDro and SPORTDiscus databases were searched from the earliest record to January 2021. Eligibility criteria: Studies were eligible if they (1) included football players aged 13 years or older, (2) used exercise-based programmes as intervention, (3) presented the number of non-contact musculoskeletal injuries (ie, defined as any acute sudden onset musculoskeletal injury that occurred without physical contact) and exposure hours for each group, and (4) had a control group (eg, usual training, minimal intervention, education). All types of exercise-based prevention programmes were eligible for inclusion. Risk of bias for each included study and overall quality of evidence for the meta-analysis were assessed. Results: Ten original randomised controlled trials with 13 355 football players and 1 062 711 hours of exposure were selected. Pooled injury risk ratio showed very low-quality evidence that exercise-based prevention programmes reduced the risk of non-contact musculoskeletal injuries by 23% (0.77 (95% CI 0.61 to 0.97)) compared with a control group. Conclusion: Exercise-based prevention programmes may reduce the risk of non-contact musculoskeletal injuries by 23% among football players. Future high-quality trials are still needed to clarify the role of exercise-based programmes in preventing non-contact musculoskeletal injuries among football players. PROSPERO registration number: CRD42020173017.

International audience; OBJECTIVE:In an attempt to understand physicians' expectations of chemotherapy, a group of lung cancer specialists was involved in an online survey investigating their opinions by a self-questionnaire. The questionnaire described five different chemotherapy prescription situations for lung cancer patients (stages IIIB or IV).METHOD:A total of 30 expert specialists were invited; 22 responded (73%). For each of the clinical situations, the expert was asked for his opinion on 3 items: cure, prolongation of survival and alleviation of symptoms. Each item was judged on a Likert scale with categories between -2 "not at all probable" and +2 "quite likely".RESULTS:For "cure", the percentage of -2 responses differed significantly according to the clinical situation (Fisher test: P

When preparing high dynamic range images (HDR) for display on standard monitors, it is often necessary to make a choice between global and local tone mapping. While the former is simple and efficient, it may fail to reproduce details in high contrast image regions. Although, the latter can better reproduce details in such regions, it often comes at the cost of increased complexity and computational time. In this paper, we present an algorithm that combines the best of both approaches. We perform local tone mapping only in high frequency image regions where the visibility of details can be an issue. In low frequency regions, we employ global tone mapping to save computational resources without degrading quality. Our algorithm is most suitable for tone mapping operators (TMOs) that utilize the concept of local adaptation luminances. © 2013 IEEE. 2309 2313 Sponsors: The Institute of Electrical and Electronics Engineers (IEEE) Signal Processing Society Conference code: 103050 Cited By :5

Large resolution High Dynamic Range (HDR) textures/images are becoming common in computer graphics applications. However, it is still a prohibitive task to perform on them a filtering step such as tone mapping in real-time. We introduce a novel technique called Selective Tone Mapper (STM) for accelerating the tone mapping step on large resolution HDR images. This technique presents an efficient memory usage, when compared with traditional methods, due to the reduced information required to localize the strong contrast areas. Sponsors: ACM Spec. Interest Group Comput. Graph. Interact. Tech. (SIGGRAPH) ACM Special Interest Group on Computer-Human Interaction (SIGCHI) Conference code: 87981 Cited By :1

The flexibility of current graphics hardware is still not enough to ensure the full implementation of an original complex algorithm such as a local tone mapping operator, which maintains the same quality performances as its original CPU implementation. Significant changes are often needed to the original CPU implementation in order to overcome many of the limitations of the current graphics hardware. As a result of this we often have reduced quality reproduction, and the frame rate of the GPU implementation is not always acceptable for real-time applications. In this paper, we show how to change the CPU implementation of a state of the art local tone mapping operator for accelerating the computation process to real time frame rates. We also present a modification of the luminance local adaptation computation, showing a simple but not yet exploited property of the Gaussian filter, allowing us to maintain the same quality appearance of the original tone mapping operator. Finally we test the hardware implementation on NVIDIA graphics cards on several images and as well as a video. We compare our hardware implementation with the corresponding CPU implementation and previous work. Copyright © 2007 by the Association for Computing Machinery, Inc. 213 218 Sponsors: Comenius University Conference code: 114606 Cited By :6

Das Antiphospholipidsyndrom (APS), mit den typischen klinischen Manifestationen von rezidivierenden Thrombosen und Aborten, wird laborchemisch durch das Vorkommen von Antiphospholipidantikörpern (aPL) definiert. Das Krankheitsbild gewinnt in letzter Zeit als mögliches Bindeglied zwischen Autoimmunität und Atherosklerose zunehmend an Bedeutung. Sowohl aPL, als auch oxidierten low-density Lipoproteinen (oxLDL) und deren Antikörpern (Anti-oxLDL) wird eine pathogenetische Bedeutung in der Atherogenese zugesprochen. In unserer Studie verglichen wir die Serumspiegel von oxLDL und AntioxLDL bei APS-Patienten (20 Patienten primäres/14 sekundäres APS) und nonAPS-Patienten (24 phänotypisch gesunde Kontrollpersonen und 12 Patienten mit Systemischem Lupus erythematodes/ SLE/) und untersuchten Assoziationen dieser Parameter zur Intima-Media-Dicke (IMT), einem klinischen Surrogatparameter der Atherosklerose. SLE-Patienten mit und ohne APS wiesen signifikant erhöhte Anti-oxLDL-Spiegel im Vergleich zur Kontrollgruppe auf (p = 0,038 bzw. p = 0,007). Dahingegen unterschieden sich die oxLDL-Konzentrationen nicht signifikant bei Kontrollen und Patienten. DieAntioxLDL- Spiegel korrelierten signifikant mit Anticardiolipin- (p = 0,002) und 2-Glykoprotein-IAntikörpern (p < 0,048), jeweils vomIgG-Isotyp. Nur SLE-Patienten ohne APS wiesen eine signifikant erhöhte Produktion reaktiver Sauerstoffspezies (ROS) als Zeichen eines proatherogenen oxidativen Stresses in der Zirkulation auf (p < 0,002). Sowohl die zirkulierenden oxLDL- als auch die AntioxLDL- Spiegel wiesen keine Assoziation zur Atherosklerose, gemessen an der IMT, bei den Patientengruppen auf. Zusammenfassend ergibt sich aus unseren experimentellen Daten kein Hinweis darauf, dass bei APS-Patienten eine durch oxidativen Stress beschleunigte Atherosklerose auftritt.

To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression.The clinical and serologic features of APS (Sapporo preliminary criteria) in 1,000 patients from 13 European countries were analyzed using a computerized database.The cohort consisted of 820 female patients (82.0%) and 180 male patients (18.0%) with a mean +/- SD age of 42 +/- 14 years at study entry. "Primary" APS was present in 53.1% of the patients; APS was associated with systemic lupus erythematosus (SLE) in 36.2%, with lupus-like syndrome in 5.0%, and with other diseases in 5.9%. A variety of thrombotic manifestations affecting the majority of organs were recorded. A catastrophic APS occurred in 0.8% of the patients. Patients with APS associated with SLE had more episodes of arthritis and livedo reticularis, and more frequently exhibited thrombocytopenia and leukopenia. Female patients had a higher frequency of arthritis, livedo reticularis, and migraine. Male patients had a higher frequency of myocardial infarction, epilepsy, and arterial thrombosis in the lower legs and feet. In 28 patients (2.8%), disease onset occurred before age 15; these patients had more episodes of chorea and jugular vein thrombosis than the remaining patients. In 127 patients (12.7%), disease onset occurred after age 50; most of these patients were men. These patients had a higher frequency of stroke and angina pectoris, but a lower frequency of livedo reticularis, than the remaining patients.APS may affect any organ of the body and display a broad spectrum of manifestations. An association with SLE, the patient's sex, and the patient's age at disease onset can modify the disease expression and define specific subsets of APS.