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9 results on '"Rocco Valluzzi"'

1. Reactivity to allergenic food contaminants: A study on products on the market

Author

Alessandro Fiocchi, Linda Monaci, Elisabetta DeAngelis, Veronica Calandrelli, Lamia Dahdah, Rocco Valluzzi, Sara Urbani, Carmen Mazzuca, Stefania Arasi, Arianna Cafarotti, Carla Riccardi, Maria Cristina Artesani, Lorenza Putignani, Valentina Pecora, Valeria Marzano, and Vincenzo Fierro

Subjects
allergen toxicity, food allergy, hazelnut allergy, milk allergy, precautionary allergen labelling, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background The frequency and severity of reactions in food‐allergic consumers exposed to unintentional food allergen contamination during production is unknown. To warn allergic consumers, it has been suggested for pre‐packaged foods to be precautionary labelled when the food allergen contamination may exceed the amount to which 1%–5% of the population could react (ED01–ED05). ED01 for hazelnut and milk have been estimated at 0.1 and 0.2 mg, respectively, by the Voluntary Incidental Trace Allergen Labelling (VITAL) initiative. The respective reference doses recommended by the FAO/WHO Codex consultation are 3 and 2 mg. We evaluated the reactivity to potential traces of milk and hazelnut allergens in allergen‐free pre‐packaged products by children affected by severe allergies to milk and hazelnuts. Methods Oral Food Challenges with commercially available hazelnut‐free wafer biscuits and milk‐free chocolate pralines were administered to patients with severe food allergies to hazelnut and cow's milk, respectively. Contamination levels of milk or hazelnut allergens were measured using chromatographic separation interfaced with triple quadrupole mass spectrometry. Results No hazelnut allergic patient showed allergic reactions to exposure to biscuits, nor any milk allergic patient displayed allergic reactions to the dark chocolate praline. While no hazelnut trace was detected in biscuits, the praline was found to be contaminated by milk at concentrations ranging between 8 and 35 mg total protein/kg food. In our dose model, these amounts exceeded 1.5–10 times the VITAL ED01 and reached the threshold suggested by the FAO/WHO Codex consultation. Conclusions Upon the consumption of food products available on the market, many patients with severe food allergies tolerate significantly higher doses of allergen than reference doses indicated in the VITAL system used for precautionary allergen labelling. These doses support the safety of the FAO/WHO recommended reference doses.

Published
2023
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2. Drug-Induced Anaphylaxis in Children

Author

Annamaria Bianchi, Rocco Valluzzi, Giuseppe Crisafulli, Paolo Bottau, Silvia Caimmi, Fabrizio Franceschini, Lucia Liotti, Francesca Mori, Sara Riscassi, Francesca Saretta, Sara Scavone, and Carlo Caffarelli

Subjects
anaphylaxis, drug, children, hypersensitivity reaction, drug-induced anaphylaxis, Biology (General), QH301-705.5
Abstract

Drug-induced anaphylaxis in children is less common than in adults and primarily involves beta-lactams and nonsteroidal anti-inflammatory drugs. Epidemiological studies show variable prevalence, influenced by age, gender, and atopic diseases. The pathophysiology includes IgE-mediated reactions and non-IgE mechanisms, like cytokine release reactions. We address drug-induced anaphylaxis in children, focusing on antibiotics, nonsteroidal anti-inflammatory drugs, neuromuscular blocking agents, and monoclonal antibodies. Diagnosis combines clinical criteria with in vitro, in vivo, and drug provocation tests. The immediate management of acute anaphylaxis primarily involves the use of adrenaline, coupled with long-term strategies, such as allergen avoidance and patient education. Desensitization protocols are crucial for children allergic to essential medications, particularly antibiotics and chemotherapy agents.

Published
2024
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5. Threshold of Reactivity and Tolerance to Precautionary Allergen-Labelled Biscuits of Baked Milk- and Egg-Allergic Children

Author

Vincenzo Fierro, Valeria Marzano, Linda Monaci, Pamela Vernocchi, Maurizio Mennini, Rocco Valluzzi, Stefano Levi Mortera, Rosa Pilolli, Lamia Dahdah, Veronica Calandrelli, Giorgia Bracaglia, Stefania Arasi, Carla Riccardi, Alessandro Fiocchi, and Lorenza Putignani

Subjects
labelling, food allergy, prevention, proteomics, mass spectrometry, cow’s milk allergy, Nutrition. Foods and food supply, TX341-641
Abstract

Extremely sensitive food-allergic patients may react to very small amounts of allergenic foods. Precautionary allergen labelling (PAL) warns from possible allergenic contaminations. We evaluated by oral food challenge the reactivity to a brand of PAL-labelled milk- and egg-free biscuits of children with severe milk and egg allergy. We explored the ability of proteomic methods to identify minute amounts of milk/egg allergens in such biscuits. Traces of milk and/or egg allergens in biscuits were measured by two different liquid-chromatography-mass spectrometry methods. The binding of patient’s serum with egg/milk proteins was assessed using immunoblotting. None of the patients reacted to biscuits. Egg and milk proteins were undetectable with a limit of detection of 0.6 µg/g for milk and egg (method A), and of 0.1 and 0.3 µg /g for milk and egg, respectively (method B). The immunoblots did not show milk/egg proteins in the studied biscuits. Milk/egg content of the biscuits is far lower than 4 µg of milk or egg protein per gram of product, the minimal doses considered theoretically capable of causing reactions. With high sensitivity, proteomic assessments predict the harmlessness of very small amount of allergens in foods, and can be used to help avoiding unnecessary PAL.

Published
2021
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6. Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects

Author

Giovanni Traina, Rocco Luigi Valluzzi, Vincenzo Fierro, Carla Riccardi, Maria Cristina Artesani, Andrea De Vuono, Alessandro Fiocchi, Alberto G. Martelli, Luis Alberto Ríos, Christian R. Alcocer, Elsy Navarrete, Blanca Estela Del Rio Navarro, Victor Gonzalez, Berenice Velasco, Herberth J. Perez Aviles, Roberto Jose Fernandez, F. Cesar Pozo, Abdal Jabbar Farhan, Hasan Arshad, Ahmed Hussain, Olena Sharikadze, Olena Okhotnikova, Javier Alcover, Diego Rodriguez, Fernando Pineda, Ilan Dalal, Jenny Weinbrand-Goichberg, Shira Benor, Menachem Rottem, Shmuel Kivity, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa, Tetiana Umanets, Youriy Antipkin, Vladyslava Barzylovich, Volodymyr Lapshyn, Mykola Umanets, Sergey Yuriev, Suzan Bekir, Tobias Pincock, Alberto Vieira Hernandez, Arnaldo Capriles Hulett, Mario Sánchez Borges, Fabiola Fabiano, Carlos Albarran, Rohit Goyal, Shilpa Gupta, Garg Gaurav, Allan T. Luskin, Noelle M. Griffin, Amy Wagelie-Steffen, Benjamin L. Trzaskoma, Susan L. Limb, William W. Busse, Robert S. Zeiger, Erika Gonzalez-Reyes, Thomas B. Casale, Bradley E. Chipps, Chizuko Sugizaki, Fumiko Goto, Akiko Yamaide, Kanako Mitsunaga, Minako Tomiita, Akira Hoshioka, Naoki Shimojo, Liviu L. Pop, Ioana-Mihaela Ciucǎ, Liviu Tǎmaş, Marilena Lazarescu, Corina Pienar, Fumiya Yamaide, Bahrul Fikri, Hironori Sato, Naoko Okishima, Miyabi Kobayashi, Mizuki Takai, Kotarou Nishigata, Ryou Yoda, Yu-ta Oana, Chifu Kajiwara, Moe Shimodaira, Tomoka Suzuki, Hiromi Iizawa, Koji Kamijo, Bijoya Karmakar, Swati Gupta Bhattacharya, Simona Blohlávková, Eliška Kopelentová, Petr Víšek, Jakub Štádler, Ivana Šetinová, Jana Novobílská, Krisa Lundelin, Seppo Salminen, Erika Isolauri, Tracy Pitt, Tamar Flanders, Marcos Peñalver, Patricia Martínez, Magdalena Lluch, Alfonso Malet, Young-Hee Nam, Hyun Jung Jin, Soo-Keol Lee, Prapasri Kulalert, Paskorn Sritipsukho, Jayanton Pathumanond, Krasimira Baynova, Marina Labella, Teresa De Aramburu, Manuel Prados, Leena Haanpää, Jasmin Aarnio, Merja Nermes, Piia af Ursin, Anne Kaljonen, Nandana Bala, Ketaki Bhagwat, James Hindley, Martin Chapman, Sivasankar Baalasubramanian, Lilijana Besednjak-Kocijančič, Koyel SenGupta, Evgeniya Antonova, Amanda M. Kong, Ahmar Iqbal, W. Gerald Teague, Benjamin Trzaskoma, Benjamin Ortiz, Brandee Paknis, Amar Iqbal, Karin Rosen, Stanley Szefler, Afaf Alblooshi, Suleiman Al-Hammadi, Arantza Vega, Raquel Gutiérrez-Rivas, Ana Maria Alonso, Juan Maria Beitia, Maria Belén Mateo, Remedios Cárdenas, Juan Jesús García-Domínguez, Raquel Pitchon dos Reis, Cristina Gonçalves Alvim, Claudia Andrade, Adriana Reis, Henrique Ribeiro, Carmen Panaitescu Bunu, Laura Marusciac, Sorin Paralescu, Paul Tamas, Carmen Panitescu Bunu, Enrique Martí Guadaño, Carolina Escobar Bolaños, Natalia Martí José, Pol Pau Casanovas, Gemma Biarnés Rib, Mariana Castells, Talía de Vicente Jiménez, Maurizio Mennini, Papola De Angelis, Francesca Rea, Monica Malamisura, Renato Tambucci, Luigi Dall’Oglio, Federica Del Chierico, Tania Napolitano, Silvia Reddel, Pamela Vernocchi, Angelo D’Ambrosio, Lorenza Putignani, Lamia Dahdah, Claudia Banzato, Luís Angel Echeverría Zudaire, Ana María Plaza, Montserrat Bosque García, Marcel Íbero, Oscar Mazzina, Valeria Marzano, Valeria Pecora, Pierluigi Koch, Valentina Pecora, Diletta Valentini, Francesca Santamaria, Rocco Valluzzi, Anwesha Mukherjee, Amit Kandhare, and Subhash Bodhankar

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2017
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7. Reactivity thresholds in children allergic to cow's milk and egg, but tolerant of baked milk and baked egg

Author

Alessandro Fiocchi, Rocco Valluzzi, Carla Riccardi, Stefania Arasi, Anna Lucia Piscitelli, Veronica Calandrelli, Lamia Dahdah, Vincenzo Fierro, and Maurizio Mennini

Subjects
food and beverages
Abstract

Background. The use of eliciting doses (EDs) for food allergens is necessary to inform individual dietary advice and food allergen risk-management. The Eliciting Dose 01 (ED01) for milk and egg, calculated from populations of allergic subjects undergoing diagnostic Oral Food Challenges (OFCs), are 0.2 mg total protein. The respective Eliciting Dose 05 (ED05) are 2.4 mg for milk and 2.3 mg for egg. As about 70% children allergic to such foods may tolerate them when baked, we sought to verify the EDs of that subpopulation of milk and egg-allergic children. Methods. We retrospectively assessed consecutive diagnostic OFC for fresh milk and egg between January 2018 and December 2020 in a population of baked food-tolerant children. Results. Among 288 children (median age 56 - IQR 36-92.5 months, 67.1% male) included, 87 (30.2%) returned positive OFC results, 38 with milk and 49 with egg. The most conservative ED01 were 0.3 mg total protein (IQR 0.03-2.9) for milk and 14.4 mg total protein (IQR 3.6-56.9) for egg. The respective ED05 were 4.2 (IQR 0.9-19.6) mg for milk and 87.7 (IQR 43-179) mg for egg. Such thresholds are respectively 1.5 (milk ED01), 1.75 (milk ED05), 72 (egg ED01), and 38.35 (egg ED05) times higher than the currently used thresholds. Conclusions The subpopulation of children allergic to milk and egg, but tolerant to baked proteins, displays higher reactivity thresholds than the general population of children allergic to milk and egg. Their risk stratification, in both individual and population terms, should consider this difference. In baked milk-tolerant children, milk causes reactions at lower doses than egg in our group of egg-tolerant children. This could be associated with the relative harmlessness of egg compared to milk in the determinism of fatal anaphylactic reactions in children

Published
2022

8. Down Syndrome in FPIES: An Overwhelming and Unexpected Prevalence

Author

Valentina Pecora, Maurizio Mennini, Rocco Valluzzi, Vincenzo Fierro, Alberto Villani, Diletta Valentini, and Alessandro Fiocchi

Subjects
Down syndrome, cow's milk proteins, food protein-induced enterocolitis syndrome, General Medicine, Settore MED/38
Abstract

Down syndrome (DS) is one of the most common chromosomal anomalies. Gastrointestinal disorders in DS are predominantly related to anatomical anomalies and celiac disease. In 2015, the first two cases of non-IgE-mediated food allergy in patients with DS were described. However, gastrointestinal symptoms experienced by subjects with DS have never been related to a possible non-IgE-mediated food allergy and a Food Protein-induced Enterocolitis syndrome (FPIES). A retrospective descriptive single-center study was conducted. Subjects included were children with acute FPIES who entered our institutional follow-up protocol between January 2013 and January 2020. Among the 85 patients (forty-nine boys—57.6%), ten (11.76%) were children with DS. In our population, the FPIES triggers included different foods (such as milk, egg, fruit, fish, wheat, soy, beef, etc.). Nine patients with DS showed FPIES reactions after ingesting cow’s milk (one even with beef and three with soy), while the last one was affected by FPIES to fish. Considering the subgroup of patients affected by cow’s milk FPIES (40 subjects overall), 22.5% had a diagnosis of DS. Patients with DS experienced acute FPIES reactions with a severity degree slightly higher than that reported in other patients, ranging from mild-moderate to severe or very severe. During the acute reactions, the patients with DS showed increased white blood cell production, absolute neutrophil count and C-reactive protein levels. This series provides a starting point for novel hypothesis-testing clinical research and possible specific immunological alterations in FPIES children with or without DS.

Published
2022

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