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Respiratory syncytial virus infection continues to be the leading cause of hospitalization due to lower respiratory tract infection in children in our country and globally. There are estimated to be more than 3.6 million hospitalizations for this cause worldwide and more than 26,000 deaths annually. The highest incidence of hospitalizations occurs in infants younger than 6 months, and certain groups are particularly vulnerable and have an increased risk of hospitalizations and death associated with respiratory syncytial virus infection. This group of patients that will be defined and treated in this document is a candidate to receive prevention strategies that have been shown to reduce the risk of a poor health outcome. This Clinical Practice Guideline is an initiative of the Mexican Academy of Pediatrics in collaboration with the Ibero-American Agency for the Development and Assessment of Health Technologies, with the objective of establishing recommendations based on the best available evidence and agreed upon by an interdisciplinary group of clinical and methodological experts. The goals of this document are to provide recommendations to reduce the risk of respiratory syncytial virus infection both in the community and in the hospital setting, primarily in infants who have an increased risk of complications and death. This document complies with international quality standards, such as those described by the United States Institute of Medicine (IOM), the Great Britain Institute of Clinical Excellence (NICE), the Collegiate Network for Scottish Guideline Development (SIGN) and the International Guidelines Network (G-I-N). An interdisciplinary Development Group of clinical experts and methodologists with experience in systematic literature reviews and the development of clinical practice guidelines was formed. A modified Delphi Panel process was conducted to extract expert opinion and achieve an appropriate level of consensus on each of the five key recommendations contained in this document. We hope that this document contributes to supporting the decision-making of health professionals, public policy makers, patient representatives and their caregivers to achieve better quality of care and, above all, reduce the burden of disease due to syncytial virus infection. respiratory in this vulnerable group. [ABSTRACT FROM AUTHOR]

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