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2. AB1417 HOW TO DIAGNOSE: JUVENILE PSORIATIC ARTHRITIS. MULTICENTER PROSPECTIVE OBSERVATIONAL STUDY IN CHILDREN WITH SUSPECTED DIAGNOSIS

Author

Palmou-Fontana, N., primary, Calvo, I., additional, Diaz Cordoves Rego, G., additional, Garcia-Rogero, A., additional, Lopez Robledillo, J. C., additional, Magallares López, B. P., additional, Mesa del Castillo, P., additional, Moreno Ruzafa, E., additional, Redondo-Figuero, C., additional, Steiner, M., additional, and Collado, P., additional

Published
2023
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4. Recurrent lipoatrophic panniculitis of children

Author

Torrelo, A., Noguera-Morel, L., Hernández-Martín, A., Clemente, D., Barja, J. M., Buzón, L., Azorín, D., de Jesús, A. A., López-Robledillo, J. C., Colmenero, I., Kutzner, H., Goldbach-Mansky, R., and Requena, L.

Published
2017
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6. Pediatric Onset (< 16 Years) Non-infectious Uveitis: Results from Spanish National Registry

Author

Mesa-Del-Castillo P, Ugarte I, Bolarin J, Montesinos B, Gonzalez H, Clemente D, Ferran I, Robledillo J, Bravo B, Prats M, Linero C, Pedraz L, Cuadros E, Perello M, Druetta N, Gago M, Calduch A, Souto A, Lopez F, Reales C, Fidalgo M, Fajardo J, Fontana N, Demetrio-Pablo R, Casano M, Garcia J, Brandy--Garcia A, Lopez A, Sevilla B, Serrano J, Tagarro A, Esteban M, Calzada J, Carrascosa J, Martin C, Verdu E, Salas E, Diaz S, Marti N, Valero M, Rosas J, Sevilla J, Nieto J, Ibares L, De Inocencio J, Tejada P, and Pascual A

Published
2021

10. Deciphering Pathways for Carotenogenesis in Haloarchaea

Author

Giani M, Miralles-Robledillo J, Peiro G, Pire C, and Martinez-Espinosa R

Subjects
bacterioruberin, antioxidant, carotenogenesis, carotenoids, natural pigments, haloarchaea
Abstract

Bacterioruberin and its derivatives have been described as the major carotenoids produced by haloarchaea (halophilic microbes belonging to the Archaea domain). Recently, different works have revealed that some haloarchaea synthetize other carotenoids at very low concentrations, like lycopene, lycopersene, cis- and trans-phytoene, cis- and trans-phytofluene, neo-beta -carotene, and neo-alpha -carotene. However, there is still controversy about the nature of the pathways for carotenogenesis in haloarchaea. During the last decade, the number of haloarchaeal genomes fully sequenced and assembled has increased significantly. Although some of these genomes are not fully annotated, and many others are drafts, this information provides a new approach to exploring the capability of haloarchaea to produce carotenoids. This work conducts a deeply bioinformatic analysis to establish a hypothetical metabolic map connecting all the potential pathways involved in carotenogenesis in haloarchaea. Special interest has been focused on the synthesis of bacterioruberin in members of the Haloferax genus. The main finding is that in almost all the genus analyzed, a functioning alternative mevalonic acid (MVA) pathway provides isopentenyl pyrophosphate (IPP) in haloarchaea. Then, the main branch to synthesized carotenoids proceeds up to lycopene from which beta -carotene or bacterioruberin (and its precursors: monoanhydrobacterioriberin, bisanhydrobacterioruberin, dihydrobisanhydrobacteriuberin, isopentenyldehydrorhodopsin, and dihydroisopenthenyldehydrorhodopsin) can be made.

Published
2020

14. Diagnostic Value and Validity of Early Spondyloarthritis Features: Results From a National Spanish Cohort

Author

Joven, Beatriz E., Navarro‐Compán, Victoria, Rosas, Jose, Fernandez Dapica, Pilar, Zarco, Pedro, de Miguel, Eugenio, Collantes, E., Carmona, L., Gobbo, M., Mulero, J., de Miguel, E., Muñoz‐Fernández, S., Zarco, P., Rivera, J., López Robledillo, J. C., Castillo Gallego, C., Rosas, J., Santos, G., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz de Rabago, E., Montilla, C., Gómez Castro, S., López, R., del Pino Montes, J., Granados Bautista, I. P., Hernández Sanz, A., Sanz Sanz, J., Fernández Prada, M., Tornero, J., Campos, C., Calvo, J., Juanola, X., Ríos, V., Moreno, E., Rotés, M. I., Ibero, I., Fernández Carballido, C., Jovaní, V., Martínez Alberola, N., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Quevedo, J. C., Rodríguez Lozano, C., Trujillo, E., Bustabad, S., A/Román Ivorra, J., Muñoz Gil, S., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Son Llatzer, H., Castro Villegas, M. C., Gratacós Matmija, J., Moreno Martínez‐Loza, M., Almodóvar, R., Rejón, E., Rodríguez Montero, S., Ruiz Jimeno, T., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., Fernández Dapica, P., Brito Brito, E., and Pérez Pampín, E.

Abstract

To evaluate the validity of different spondyloarthritis (SpA) features included in the Berlin diagnostic algorithm and the Assessment of SpondyloArthritis international Society (ASAS) classification criteria in an early SpA cohort. This was a longitudinal multicenter study including patients from the ESPeranza program cohort who were suspected to have SpA. Subjects were ≤45 years old, and SpA symptom duration was 3–24 months. Patients with axial SpA symptoms were selected and categorized according to diagnosis (yes/no) of axial SpA. Descriptive analysis was performed, and the sensitivity, specificity, predictive value, and likelihood ratio (LR) of each feature were calculated. Of 775 patients suspected to have SpA, 665 had predominantly axial symptoms and 516 of these patients were diagnosed with axial SpA. The most useful SpA features were sacroiliitis on magnetic resonance imaging (positive LR 6.6) or radiograph (positive LR 31.1) and peripheral arthritis (positive LR 8.9). The features with the lowest diagnostic utility were a family history of SpA (positive LR 1.5) and good response to nonsteroidal antiinflammatory drugs (positive LR 1.6). Inflammatory back pain (IBP; according to ASAS criteria) was described in only 27% of SpA patients, with a positive LR of 2.3. HLA–B27 positivity was present in 245 (48%), and the positive LR was 2.8. The diagnostic value of SpA features in patients with early axial SpA seems to be different than in patients with longstanding disease. Chronic back pain is better than IBP as an entry point to the diagnostic algorithm. Sacroiliitis on imaging is very important for early diagnosis, while the use of HLA–B27 status as a key factor is questionable.

Published
2017
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15. Disease Activity As a Major Determinant of Quality of Life and Physical Function in Patients With Early Axial Spondyloarthritis

Author

Fernández‐Carballido, Cristina, Navarro‐Compán, Victoria, Castillo‐Gallego, Concepción, Castro‐Villegas, Maria C., Collantes‐Estévez, Eduardo, de Miguel, Eugenio, Collantes, E., Reina Sofía, H., Carmona, L., Gobbo, M., Mulero, J., Puerta de Hierro, H., Muñoz‐Fernández, S., Infanta Sofía, H., Zarco, P., Alcorcón, F. H., Rivera, J., Gregorio Marañón, H., López Robledillo, J. C., Niño Jesús, H., Castillo Gallego, C., La Paz, H. U., Rosas, J., Santos, G., Marina Baixa, H., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz de Rabago, E., Juanv, H. U., Montilla, C., Gómez Castro López, S., del Pino Montes, R. J., de Salamanca, H. U., Granados Bautista, I. P., Hernández Sanz, A., Virgen de la Salud, H., Sanz Sanz, J., Puerta de Hierro, H., Fernández Prada, M., Tornero, J., de Guadalajara, H. U., Campos, C., Calvo, J., de Valencia, H. G. U., Juanola, X., Ríos, V., de Bellvitge, H. U., Moreno, E., Rotés, M. I., de San Rafael, H., Ibero, I., Jovaní, V., Martínez Alberola, N., de Elda, H. G. U., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Virgen de la Arrixaca, H. U., Quevedo, J. C., Rodríguez Lozano, C., Negrín, H. U., Trujillo, E., Bustabad, S., de Canarias, H. U., Román Ivorra, J. A., Muñoz Gil, S., Peset, H. U., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Son Llatzer, H., Gratacós Matmija, J., Moreno Martínez‐Loza, M., Sabadell, H., Almodóvar, R., Fundación Alcorcón, H., Rejón, E., Rodríguez Montero, S., Virgen de Valme, H. U., Ruiz Jimeno, T., Sierrallana, H., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., de Mérida, H., Fernández Dapica, P., Brito Brito, E., Ramón y Cajal, H., Pérez Pampín, E., and Clínico, H.

Abstract

To describe health‐related quality of life (HRQOL) and physical function in patients with early axial spondyloarthritis (SpA) and to assess their associations with disease activity and radiographic damage. This was a cross‐sectional study drawing upon baseline data of axial SpA patients (Assessment of SpondyloArthritis international Society criteria) from the ESPERANZA cohort. Linear regression analyses were used to evaluate the associations between disease activity and radiographic damage (spine and sacroiliac joints) with HRQOL, physical function, and spinal mobility. In total, 259 patients were included. The mean ± SD age was 32.2 ± 6.9 years, disease duration was 13.3 ± 6.8 months, Ankylosing Spondylitis Quality of Life score was 5.9 ± 4.8, Bath Ankylosing Spondylitis Functional Index score was 2.4 ± 2.3, Bath Ankylosing Spondylitis Metrology Index score was 1.4 ± 1.3, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was 3.8 ± 2.3, C‐reactive protein (CRP) level was 9.7 ± 13.2 mg/liter, and Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI‐s) score was 1.7 ± 1.6. HRQOL was mainly associated with disease activity on univariate analysis (β values for BASDAI 0.646, patient global visual analog scale [VAS] 0.641, night back pain VAS 0.598, physician VAS 0.560, and CRP level 0.275; P< 0.01 for all), whereas the association with radiographic damage was weaker (standardized β for BASRI‐s 0.142; P< 0.05). On multivariate models, HRQOL only remained significantly associated with disease activity (standardized β for BASDAI 0.330; P< 0.01, and physician VAS 0.205 and night back pain VAS 0.210; P= 0.01). Similarly, physical function was associated with disease activity and radiographic damage on univariate analysis, but only with disease activity (BASDAI β 0.466; P< 0.01) on multivariate analysis. However, spinal mobility was associated with radiographic damage in both univariate and multivariate analyses. Patients with axial SpA already have impaired quality of life and physical function, albeit mildly, at the beginning of their disease course. Both outcomes are mainly associated with disease activity in these patients.

Published
2017
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17. Subdural empyema with extension to vertebral canal secondary to salmonellosis in a patient with systemic lupus erythematosus

Author

Sastre, C. Alvarez, Villarejo, F., Robledillo, J. López, Martin-Gamero, Pascual A., and Díaz, C. Pérez

Abstract

Case report. A case of supratentorial subdural empyema extending to the superior subdural cervical space in a 14-year-old patient with systemic lupus erythematosus is presented. The presumed etiology of the empyema was an intestinal nontyphoidal salmonella infection. Discussion. We review the neurological and neurosurgical complications in systemic lupus erythematosus.

Published
2002
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20. Differences between familial and sporadic early spondyloarthritis: Results from the ESPERANZA cohort

Author

Almodóvar, R., Navarro-Compán, V., Fernández-Carballido, C., Hernández, A., Miguel, E., Zarco, P., Collantes, E., Carmona, L., Gobbo, M., Mulero, J., Muñoz-Fernández, S., Infanta Sofía, H., Rivera, J., López Robledillo, J. C., Castillo Gallego, C., Rosas, J., Santos, G., Fernández Sueiro, J. L., Pinto Tasende, J., González Díaz Rabago, E., Montilla, C., Gómez Castro, S., López, R., Del Pino Montes, J., Granados Bautista, I. P., Hernández Sanz, A., Sanz Sanz, J., Fernández Prada, M., Tornero, J., Campos, C., Calvo, J., Juanola, X., Ríos, V., Moreno, E., Rotés, M. I., Ibero, I., Jovaní, V., Martínez Alberola, N., Linares, L. F., Moreno Ramos, M. J., Uceda, A., Moreno Martínez, M. J., Beteta, M. D., Quevedo, J. C., Rodríguez Lozano, C., Trujillo, E., Bustabad, S., Román Ivorra, J. A., Muñoz Gil, S., Juan Mas, A., Ros Vilamajó, I., Ibáñez Barceló, M., Castro Villegas, M. C., Gratacós Matmija, J., Moreno Martínez-Loza, M., Rejón, E., Rodríguez Montero, S., Ruiz Jimeno, T., Aznar, J. J., Chamizo Carmona, E., Garrido Puñal, N., Fernández Dapica, P., Brito Brito, E., and Pérez Pampín, E.

23. [Recommendations for the use of methotrexate in patients with juvenile idiopathic arthritis].

Author

Calvo I, Antón J, López Robledillo JC, de Inocencio J, Gamir ML, Merino R, Lacruz L, Camacho M, Rua MJ, Bustabad S, and Díaz Cordovés-Rego G

Subjects
Arthritis drug therapy, Blood Cell Count, Humans, Methotrexate administration & dosage, Remission Induction, Risk Factors, Uveitis drug therapy, Arthritis, Juvenile drug therapy, Methotrexate therapeutic use
Abstract

Objectives: To develop a consensus document of recommendations for the use of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA)., Material and Method: A group of eleven experts proposed several clinical questions on the use of MTX in patients with JIA. A systematic review was conducted and the evidence and recommendations for each question were extracted. The results were discussed and validated by the experts in a work session to establish the final recommendations., Results: MTX is recommended as the first drug for inducing remission in JIA, and its indication should be made according to the clinical category of the patient. Prior to treatment, it is recommended to perform a complete blood count, including white cells, levels of liver enzymes, serum creatinine, and other analytical parameters according to specific risk factors. Treatment should be initiated with a dose of 10-15 mg/m(2)/week. In cases of uveitis or polyarthritis, an initial dose of 15 mg/m(2)/week should be considered. For a better bioavailability and tolerability, it is preferable to administer MTX parenterally if the dose is ≥15 mg/m(2)/week. It is necessary to periodically perform an analytical monitoring of the patient and to assess possible alterations in liver enzymes to make changes if necessary. Combinations with biological agents may be necessary, as well as the concomitant addition of folic or folinic acid., Conclusions: This document describes the main recommendations for the appropriate use of MTX in JIA patients, according to scientific evidence and clinical experience., (Copyright © 2015 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved.)

Published
2016
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27. [Reactive arthritis shortly after Streptococcus b-hemolyticus type A and Salmonella type B infection].

Author

Gómez Carrasco J, Carrasco Torres A, Sevilla Ramos P, López Robledillo J, and García De Frías E

Subjects
Arthritis, Reactive etiology, Child, Preschool, Female, Humans, Salmonella Infections complications, Streptococcal Infections complications, Arthritis, Reactive diagnosis, Salmonella Infections diagnosis, Streptococcal Infections diagnosis
Abstract

We report the case of a girl aged 2 years and 8 months with monoarticular arthritis of the knee. Onset and outcome were slow. The child had suffered uncomplicated pharyngitis and a diarrheal process 1 and 2 weeks respectively prior to developing the disease. Additional data suggested the presence of reactive arthritis after Streptococcus infection. Salmonella was also detected in the feces. Unlike rheumatic fever, post-streptococcus reactive arthritis does not follow Jones' criteria and the clinical course is slow. Because gastrointestinal infection with both Streptococcus and Salmonella occurred simultaneously, the interaction between both agents, each of which alone can cause reactive arthritis, might have produced a synergic action in our patient.

Published
2001

28. [Childhood cutaneous polyarteritis nodosa].

Author

Núñez Giralda A, Espejo Ortega M, Ibáñez Rubio M, Torrelo Fernández A, González Medierod I, and López Robledillo J

Subjects
Biopsy, Child, Preschool, Glucocorticoids therapeutic use, Humans, Male, Polyarteritis Nodosa drug therapy, Skin pathology, Polyarteritis Nodosa diagnosis
Abstract

Cutaneous polyarteritis nodosa is a form of polyarteritis nodosa. It is a rare disease in children and is characterized by its benign and chronic course. There is no evidence of hypertension or organ dysfunction. The aim of this study was to present a case of cutaneous polyarteritis nodosa and to review the literature. We describe the case of a 3-year-old male child with multiple, red, painful, edematous nodules of the extremities and trunk. Dermatologic findings were accompanied by fever and arthritis. Laboratory findings showed an acute phase response associated with raised antistreptolysin titer. Diagnosis was based on biopsy of the affected skin lesion in which necrotizing arteritis of the lower dermis with neutrophilic and eosinophilic infiltrates was found. The patient responded well to corticosteroid therapy. The evaluation of children with cutaneous polyarteritis nodosa should include laboratory studies to detect streptococcal infection.

Published
2001

29. [CINCA syndrome. An infrequent systemic process].

Author

López Saldaña D, Ibáñez Rubio M, Brañas Fernández P, Rodríuez Serrano F, and López Robledillo JC

Subjects
Anti-Inflammatory Agents therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Antimetabolites, Antineoplastic therapeutic use, Arthropathy, Neurogenic drug therapy, Aspirin therapeutic use, Child, Humans, Male, Methotrexate therapeutic use, Prednisone therapeutic use, Syndrome, Arthropathy, Neurogenic diagnosis
Published
1998

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