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This paper discusses findings from research conducted in an inner-city middle school in England where the majority of pupils spoke languages other than English as a first language. The research was motivated both by a belief that the language needs of English as an additional language (EAL) pupils are not properly addressed in the National Curriculum and by a specific concern of the subject teachers that the EAL pupils' small English vocabularies resulted in their lack of oral participation in lessons and contributed to their below average attainment. The paper discusses the effects on the pupils' learning of subject teachers' practices in teaching key vocabulary in science and geography lessons. It argues that a more explicit, systematic and principled approach to vocabulary teaching needs to be integrated into National Curriculum pedagogy.

Objective: Sex steroid levels in women vary with increasing age from the age of 70 years (70+). Whether this reflects change within individuals with age or a survival advantage is not known. This study aimed to determine the stability of circulating sex steroids and SHBG over time in individual women aged 70+. Design: A prospective cohort study. Participants: 400 women, aged 70+ not using any sex steroid, anti‐androgen/oestrogen or glucocorticoid therapy. Main outcome measurements: Sex steroid concentrations, measured by liquid chromatography‐tandem mass spectrometry and sex hormone‐binding globulin (SHBG) by immunoassay, in paired blood samples drawn 3 years apart and analysed together. Results: 400 women, median (IQR) age 78.0 (8.6) years, were included in the analysis. Mean testosterone concentrations were statistically significantly higher in follow‐up samples compared with baseline. The change was modest (mean change 31 pmol/L, 95% confidence interval (CI) 2.4–59.8; p =.034), and an increase was not observed in all women. There was a statistically significant decline in mean body mass index (mean change −0.4 kg/m2, 95% CI 0.6 to −0.3; p <.001) and a significant increase in the mean serum SHBG concentration (mean change 4.0 nmol/L, 95% CI 2.7–5.4; p <.001). The change observed in testosterone was not explained by the observed change in SHBG. There was no significant change in the mean oestrone or dehydroepiandrosterone concentration. Conclusions: Testosterone concentrations in women aged 70+ were more likely to increase than decrease. Whether increasing testosterone concentrations in older women confer a survival advantage needs investigation. [ABSTRACT FROM AUTHOR]

Importance: After menopause, estradiol (E2) is predominately an intracrine hormone circulating in very low serum concentrations.Objective: The objective of this work is to examine determinants of E2 concentrations in women beyond age 70 years.Design and Setting: A cross-sectional, community-based study was conducted.Participants: A total of 5325 women participated, with a mean age of 75.1 years (± 4.2 years) and not using any sex steroid, antiandrogen/estrogen, glucocorticoid, or antiglycemic therapy.Main Outcome Measures: Sex steroids were measured by liquid chromatography-tandem mass spectrometry. Values below the limit of detection (LOD; E2 11 pmol/L [3 pg/mL] were assigned a value of LOD/√2 to estimate total E2.Results: E2 and estrone (E1) were below the LOD in 66.1% and 0.9% of women, respectively. The median (interdecile ranges) for E1 and detectable E2 were 181.2 pmol/L (range, 88.7-347.6 pmol/L) and 22.0 pmol/L (range, 11.0-58.7 pmol/L). Women with undetectable E2 vs detectable E2 were older (median age 74.1 years vs 73.8, P = .02), leaner (median body mass index [BMI] 26.8 kg/m2 vs 28.5, P < .001), and had lower E1, testosterone and DHEA concentrations (P < .001). A linear regression model, including age, BMI, E1, and testosterone, explained 20.9% of the variation in total E2, but explained only an additional 1.2% of variation over E1 alone. E1 and testosterone made significant contributions (r2 = 0.162, P < .001) in a model for the subset of women with detectable E2.Conclusions: Our findings support E1 as a principal circulating estrogen and demonstrate a robust association between E1 and E2 concentrations in postmenopausal women. Taken together with prior evidence for associations between E1 and health outcomes, E1 should be included in studies examining associations between estrogen levels and health outcomes in postmenopausal women. [ABSTRACT FROM AUTHOR]

A response from authors of the article "Incidence of total knee and hip replacement for osteoarthritis in relation to circulating sex steroid hormone concentrations in women" is presented.

Several letters to the editor are presented including two in response to the article "Urinary incontinence in young nulligravid women: a cross-sectional analysis," by Penelope J. Robinson and colleagues in the 2012 issue, and also includes a response from the authors to the above mentioned issue.