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224 results on '"Robinson, Christina M."'

3. Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability

Author

Feng, Yang, Lee, Jaewon, Yang, Liping, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Edupuganti, Veera V. Shivaji R., Hsu, Kuo-Sheng, Dower, Christopher, Yu, Guojun, So, Daeho, Bajgain, Pradip, Zhu, Zhongyu, Dimitrov, Dimiter S., Patel, Nimit L., Robinson, Christina M., Difilippantonio, Simone, Dyba, Marzena, Corbel, Amanda, Basuli, Falguni, Swenson, Rolf E., Kalen, Joseph D., Suthe, Sreedhar Reddy, Hussain, Myer, Italia, James S., Souders, Colby A., Gao, Ling, Schnermann, Martin J., and St. Croix, Brad

Published
2023
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7. Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum-based chemotherapy

Author

Breekveldt, Emilie C. H., Ykema, Berbel L. M., Bisseling, Tanya M., Moons, Leon M. G., Spaander, Manon C. W., Huibregtse, Inge L., van Der Biessen-van Beek, Dorien T. J., Mulder, Sasja F., Saveur, Lisette, Kerst, J. Martijn, Zweers, Danielle, Suelmann, Britt B. M., de Wit, Ronald, Reijm, Agnes, van Baalen, Sophia, Butterly, Lynn F., Hisey, William M., Robinson, Christina M., van Vuuren, Anneke J., Carvalho, Beatriz, Lansdorp-Vogelaar, Iris, Schaapveld, Michael, van Leeuwen, Flora E., Snaebjornsson, Petur, van Leerdam, Monique E., Breekveldt, Emilie C. H., Ykema, Berbel L. M., Bisseling, Tanya M., Moons, Leon M. G., Spaander, Manon C. W., Huibregtse, Inge L., van Der Biessen-van Beek, Dorien T. J., Mulder, Sasja F., Saveur, Lisette, Kerst, J. Martijn, Zweers, Danielle, Suelmann, Britt B. M., de Wit, Ronald, Reijm, Agnes, van Baalen, Sophia, Butterly, Lynn F., Hisey, William M., Robinson, Christina M., van Vuuren, Anneke J., Carvalho, Beatriz, Lansdorp-Vogelaar, Iris, Schaapveld, Michael, van Leeuwen, Flora E., Snaebjornsson, Petur, and van Leerdam, Monique E.

Abstract

Testicular cancer survivors (TCS) treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC). We determined the yield of colonoscopy in TCS to assess its potential in reducing CRC incidence and mortality. We conducted a colonoscopy screening study among TCS in four Dutch hospitals to assess the yield of colorectal neoplasia. Neoplasia was defined as adenomas, serrated polyps (SPs), advanced adenomas (AAs: ≥10 mm diameter, high-grade dysplasia or ≥25% villous component), advanced serrated polyps (ASPs: ≥10 mm diameter or dysplasia) or CRC. Advanced neoplasia (AN) was defined as AA, ASP or CRC. Colonoscopy yield was compared to average-risk American males who underwent screening colonoscopy (n = 24,193) using a propensity score matched analysis, adjusted for age, smoking status, alcohol consumption and body mass index. A total of 137 TCS underwent colonoscopy. Median age was 50 years among TCS (IQR 43–57) vs 55 years (IQR 51–62) among American controls. A total of 126 TCS were matched to 602 controls. The prevalence of AN was higher in TCS than in controls (8.7% vs 1.7%; P =.0002). Nonadvanced adenomas and SPs were detected in 45.2% of TCS vs 5.5% of controls (P <.0001). No lesions were detected in 46.0% of TCS vs 92.9% of controls (P <.0001). TCS treated with platinum-based chemotherapy have a higher prevalence of neoplasia and AN than matched controls. These results support our hypothesis that platinum-based chemotherapy increases the risk of colorectal neoplasia in TCS. Cost-effectiveness studies are warranted to ascertain the threshold of AN prevalence that justifies the recommendation of colonoscopy for TCS.

Published
2024

8. Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum-based chemotherapy

Author

MS MDL 1, Cancer, MS Medische Oncologie, Breekveldt, Emilie C H, Ykema, Berbel L M, Bisseling, Tanya M, Moons, Leon M G, Spaander, Manon C W, Huibregtse, Inge L, van der Biessen-van Beek, Dorien T J, Mulder, Sasja F, Saveur, Lisette, Kerst, J Martijn, Zweers, Danielle, Suelmann, Britt B M, de Wit, Ronald, Reijm, Agnes, van Baalen, Sophia, Butterly, Lynn F, Hisey, William M, Robinson, Christina M, van Vuuren, Anneke J, Carvalho, Beatriz, Lansdorp-Vogelaar, Iris, Schaapveld, Michael, van Leeuwen, Flora E, Snaebjornsson, Petur, van Leerdam, Monique E, MS MDL 1, Cancer, MS Medische Oncologie, Breekveldt, Emilie C H, Ykema, Berbel L M, Bisseling, Tanya M, Moons, Leon M G, Spaander, Manon C W, Huibregtse, Inge L, van der Biessen-van Beek, Dorien T J, Mulder, Sasja F, Saveur, Lisette, Kerst, J Martijn, Zweers, Danielle, Suelmann, Britt B M, de Wit, Ronald, Reijm, Agnes, van Baalen, Sophia, Butterly, Lynn F, Hisey, William M, Robinson, Christina M, van Vuuren, Anneke J, Carvalho, Beatriz, Lansdorp-Vogelaar, Iris, Schaapveld, Michael, van Leeuwen, Flora E, Snaebjornsson, Petur, and van Leerdam, Monique E

Published
2024

10. Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum‐based chemotherapy

Author

Breekveldt, Emilie C. H., primary, Ykema, Berbel L. M., additional, Bisseling, Tanya M., additional, Moons, Leon M. G., additional, Spaander, Manon C. W., additional, Huibregtse, Inge L., additional, van der Biessen‐van Beek, Dorien T. J., additional, Mulder, Sasja F., additional, Saveur, Lisette, additional, Kerst, J. Martijn, additional, Zweers, Danielle, additional, Suelmann, Britt B. M., additional, de Wit, Ronald, additional, Reijm, Agnes, additional, van Baalen, Sophia, additional, Butterly, Lynn F., additional, Hisey, William M., additional, Robinson, Christina M., additional, van Vuuren, Anneke J., additional, Carvalho, Beatriz, additional, Lansdorp‐Vogelaar, Iris, additional, Schaapveld, Michael, additional, van Leeuwen, Flora E., additional, Snaebjornsson, Petur, additional, and van Leerdam, Monique E., additional

Published
2023
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13. Data from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer

Author

Khan, Imran, primary, Gril, Brunilde, primary, Paranjape, Anurag N., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Biernat, Wojciech, primary, Bieńkowski, Michał, primary, Pęksa, Rafał, primary, Duchnowska, Renata, primary, Jassem, Jacek, primary, Brastianos, Priscilla K., primary, Metellus, Philippe, primary, Bialecki, Emilie, primary, Woodroofe, Carolyn C., primary, Wu, Haitao, primary, Swenson, Rolf E., primary, and Steeg, Patricia S., primary

Published
2023
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14. Supplementary Figure S1-S10 from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer

Author

Khan, Imran, primary, Gril, Brunilde, primary, Paranjape, Anurag N., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Biernat, Wojciech, primary, Bieńkowski, Michał, primary, Pęksa, Rafał, primary, Duchnowska, Renata, primary, Jassem, Jacek, primary, Brastianos, Priscilla K., primary, Metellus, Philippe, primary, Bialecki, Emilie, primary, Woodroofe, Carolyn C., primary, Wu, Haitao, primary, Swenson, Rolf E., primary, and Steeg, Patricia S., primary

Published
2023
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15. Supplementary Table 1 from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer

Author

Khan, Imran, primary, Gril, Brunilde, primary, Paranjape, Anurag N., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Biernat, Wojciech, primary, Bieńkowski, Michał, primary, Pęksa, Rafał, primary, Duchnowska, Renata, primary, Jassem, Jacek, primary, Brastianos, Priscilla K., primary, Metellus, Philippe, primary, Bialecki, Emilie, primary, Woodroofe, Carolyn C., primary, Wu, Haitao, primary, Swenson, Rolf E., primary, and Steeg, Patricia S., primary

Published
2023
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16. Supplementary Material and Methods from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer

Author

Khan, Imran, primary, Gril, Brunilde, primary, Paranjape, Anurag N., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Biernat, Wojciech, primary, Bieńkowski, Michał, primary, Pęksa, Rafał, primary, Duchnowska, Renata, primary, Jassem, Jacek, primary, Brastianos, Priscilla K., primary, Metellus, Philippe, primary, Bialecki, Emilie, primary, Woodroofe, Carolyn C., primary, Wu, Haitao, primary, Swenson, Rolf E., primary, and Steeg, Patricia S., primary

Published
2023
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18. Using New Hampshire Colonoscopy Registry data to assess United States and European post-polypectomy surveillance guidelines

Author

Liu, Margaret C., Anderson, Joseph C., Hisey, William, MacKenzie, Todd A., Robinson, Christina M., and Butterly, Lynn F.

Subjects
Gastroenterology, Article
Abstract

Background Our goal was to compare the updated European Society of Gastrointestinal Endoscopy (ESGE) and United States Multi-Society Task Force on Colorectal Cancer (USMSTF) high risk groups in predicting metachronous advanced neoplasia on first follow-up colonoscopy and long-term colorectal cancer (CRC). Methods We compared advanced metachronous neoplasia risk (serrated polyps ≥ 1 cm or with dysplasia, advanced adenomas [≥ 1 cm, villous, high grade dysplasia], CRC) on first surveillance colonoscopy in patients with high risk findings according to ESGE versus USMSTF guidelines. We also compared the positive and negative predictive values (PPV, NPV) of both guidelines for metachronous neoplasia. Results The risk for metachronous neoplasia in our sample (n = 20 458) was higher in the high risk USMSTF (3 year) (13.6 %; 95 %CI 12.3–14.9) and ESGE groups (13.6 %; 95 %CI 12.3–15.0) compared with the lowest risk USMSTF (5.1 %; 95 %CI 4.7–5.5; P Conclusion Performance characteristics for the ESGE and USMSTF recommendations are similar in predicting metachronous advanced neoplasia and long-term CRC. The addition of risk groups, such as the USMSTF 5–10-year and 3–5-year groups to the USMSTF 3-year category did not alter the PPV or NPV significantly.

Published
2022

21. Supplementary Methods from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, primary, Nyswaner, Katherine M., primary, Bensen, Ryan C., primary, Ritt, Daniel A., primary, Specht, Suzanne I., primary, Das, Sudipto, primary, Andresson, Thorkell, primary, Cachau, Raul E., primary, Liang, Roger J., primary, Ries, Amy L., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Gouker, Brad, primary, Bassel, Laura, primary, Karim, Baktiar O., primary, Miller, Chad J., primary, Turk, Benjamin E., primary, Morrison, Deborah K., primary, and Brognard, John, primary

Published
2023
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22. Supplementary Tables from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, primary, Nyswaner, Katherine M., primary, Bensen, Ryan C., primary, Ritt, Daniel A., primary, Specht, Suzanne I., primary, Das, Sudipto, primary, Andresson, Thorkell, primary, Cachau, Raul E., primary, Liang, Roger J., primary, Ries, Amy L., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Gouker, Brad, primary, Bassel, Laura, primary, Karim, Baktiar O., primary, Miller, Chad J., primary, Turk, Benjamin E., primary, Morrison, Deborah K., primary, and Brognard, John, primary

Published
2023
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23. Data from Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma

Author

Kowalczyk, Joshua T., primary, Wan, Xiaolin, primary, Hernandez, Edjay R., primary, Luo, Ruibai, primary, Lyons, Gaelyn C., primary, Wilson, Kelli M., primary, Gallardo, Devorah C., primary, Isanogle, Kristine A., primary, Robinson, Christina M., primary, Mendoza, Arnulfo, primary, Heske, Christine M., primary, Chen, Jinqui-Qiu, primary, Luo, Xiaoling, primary, Kelly, Alexander E., primary, Difilippantinio, Simone, primary, Robey, Robert W., primary, Thomas, Craig J., primary, Sackett, Dan L., primary, Morrison, Deborah K., primary, Randazzo, Paul A., primary, Jenkins, Lisa M. Miller, primary, and Yohe, Marielle E., primary

Published
2023
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24. Supplementary Figure S8.1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, primary, Nyswaner, Katherine M., primary, Bensen, Ryan C., primary, Ritt, Daniel A., primary, Specht, Suzanne I., primary, Das, Sudipto, primary, Andresson, Thorkell, primary, Cachau, Raul E., primary, Liang, Roger J., primary, Ries, Amy L., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Gouker, Brad, primary, Bassel, Laura, primary, Karim, Baktiar O., primary, Miller, Chad J., primary, Turk, Benjamin E., primary, Morrison, Deborah K., primary, and Brognard, John, primary

Published
2023
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25. Supplementary Movie 1 from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, primary, Nyswaner, Katherine M., primary, Bensen, Ryan C., primary, Ritt, Daniel A., primary, Specht, Suzanne I., primary, Das, Sudipto, primary, Andresson, Thorkell, primary, Cachau, Raul E., primary, Liang, Roger J., primary, Ries, Amy L., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Gouker, Brad, primary, Bassel, Laura, primary, Karim, Baktiar O., primary, Miller, Chad J., primary, Turk, Benjamin E., primary, Morrison, Deborah K., primary, and Brognard, John, primary

Published
2023
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26. Data from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, primary, Nyswaner, Katherine M., primary, Bensen, Ryan C., primary, Ritt, Daniel A., primary, Specht, Suzanne I., primary, Das, Sudipto, primary, Andresson, Thorkell, primary, Cachau, Raul E., primary, Liang, Roger J., primary, Ries, Amy L., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Gouker, Brad, primary, Bassel, Laura, primary, Karim, Baktiar O., primary, Miller, Chad J., primary, Turk, Benjamin E., primary, Morrison, Deborah K., primary, and Brognard, John, primary

Published
2023
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27. Supplementary Figures from TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, primary, Nyswaner, Katherine M., primary, Bensen, Ryan C., primary, Ritt, Daniel A., primary, Specht, Suzanne I., primary, Das, Sudipto, primary, Andresson, Thorkell, primary, Cachau, Raul E., primary, Liang, Roger J., primary, Ries, Amy L., primary, Robinson, Christina M., primary, Difilippantonio, Simone, primary, Gouker, Brad, primary, Bassel, Laura, primary, Karim, Baktiar O., primary, Miller, Chad J., primary, Turk, Benjamin E., primary, Morrison, Deborah K., primary, and Brognard, John, primary

Published
2023
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28. Supplementary Data from Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma

Author

Kowalczyk, Joshua T., primary, Wan, Xiaolin, primary, Hernandez, Edjay R., primary, Luo, Ruibai, primary, Lyons, Gaelyn C., primary, Wilson, Kelli M., primary, Gallardo, Devorah C., primary, Isanogle, Kristine A., primary, Robinson, Christina M., primary, Mendoza, Arnulfo, primary, Heske, Christine M., primary, Chen, Jinqui-Qiu, primary, Luo, Xiaoling, primary, Kelly, Alexander E., primary, Difilippantinio, Simone, primary, Robey, Robert W., primary, Thomas, Craig J., primary, Sackett, Dan L., primary, Morrison, Deborah K., primary, Randazzo, Paul A., primary, Jenkins, Lisa M. Miller, primary, and Yohe, Marielle E., primary

Published
2023
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29. Supplementary Figure S2 from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author

Hebron, Katie E., primary, Wan, Xiaolin, primary, Roth, Jacob S., primary, Liewehr, David J., primary, Sealover, Nancy E., primary, Frye, William J.E., primary, Kim, Angela, primary, Stauffer, Stacey, primary, Perkins, Olivia L., primary, Sun, Wenyue, primary, Isanogle, Kristine A., primary, Robinson, Christina M., primary, James, Amy, primary, Awasthi, Parirokh, primary, Shankarappa, Priya, primary, Luo, Xiaoling, primary, Lei, Haiyan, primary, Butcher, Donna, primary, Smith, Roberta, primary, Edmondson, Elijah F., primary, Chen, Jin-Qiu, primary, Kedei, Noemi, primary, Peer, Cody J., primary, Shern, Jack F., primary, Figg, W. Douglas, primary, Chen, Lu, primary, Hall, Matthew D., primary, Difilippantonio, Simone, primary, Barr, Frederic G., primary, Kortum, Robert L., primary, Robey, Robert W., primary, Vaseva, Angelina V., primary, Khan, Javed, primary, and Yohe, Marielle E., primary

Published
2023
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30. Supplementary Data File S5 from The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author

Hebron, Katie E., primary, Wan, Xiaolin, primary, Roth, Jacob S., primary, Liewehr, David J., primary, Sealover, Nancy E., primary, Frye, William J.E., primary, Kim, Angela, primary, Stauffer, Stacey, primary, Perkins, Olivia L., primary, Sun, Wenyue, primary, Isanogle, Kristine A., primary, Robinson, Christina M., primary, James, Amy, primary, Awasthi, Parirokh, primary, Shankarappa, Priya, primary, Luo, Xiaoling, primary, Lei, Haiyan, primary, Butcher, Donna, primary, Smith, Roberta, primary, Edmondson, Elijah F., primary, Chen, Jin-Qiu, primary, Kedei, Noemi, primary, Peer, Cody J., primary, Shern, Jack F., primary, Figg, W. Douglas, primary, Chen, Lu, primary, Hall, Matthew D., primary, Difilippantonio, Simone, primary, Barr, Frederic G., primary, Kortum, Robert L., primary, Robey, Robert W., primary, Vaseva, Angelina V., primary, Khan, Javed, primary, and Yohe, Marielle E., primary

Published
2023
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31. Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer

Author

Khan, Imran, primary, Gril, Brunilde, additional, Paranjape, Anurag N., additional, Robinson, Christina M., additional, Difilippantonio, Simone, additional, Biernat, Wojciech, additional, Bieńkowski, Michał, additional, Pęksa, Rafal, additional, Duchnowska, Renata, additional, Jassem, Jacek, additional, Brastianos, Priscilla K., additional, Metellus, Philippe, additional, Bialecki, Emilie, additional, Woodroofe, Carolyn C., additional, Wu, Haitao, additional, Swenson, Rolf E., additional, and Steeg, Patricia S., additional

Published
2023
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32. Response

Author

Anderson, Joseph C., primary, Robinson, Christina M., additional, and Butterly, Lynn F., additional

Published
2023
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37. The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Author

Hebron, Katie E., primary, Wan, Xiaolin, additional, Roth, Jacob S., additional, Liewehr, David J., additional, Sealover, Nancy E., additional, Frye, William J.E., additional, Kim, Angela, additional, Stauffer, Stacey, additional, Perkins, Olivia L., additional, Sun, Wenyue, additional, Isanogle, Kristine A., additional, Robinson, Christina M., additional, James, Amy, additional, Awasthi, Parirokh, additional, Shankarappa, Priya, additional, Luo, Xiaoling, additional, Lei, Haiyan, additional, Butcher, Donna, additional, Smith, Roberta, additional, Edmondson, Elijah F., additional, Chen, Jin-Qiu, additional, Kedei, Noemi, additional, Peer, Cody J., additional, Shern, Jack F., additional, Figg, W. Douglas, additional, Chen, Lu, additional, Hall, Matthew D., additional, Difilippantonio, Simone, additional, Barr, Frederic G., additional, Kortum, Robert L., additional, Robey, Robert W., additional, Vaseva, Angelina V., additional, Khan, Javed, additional, and Yohe, Marielle E., additional

Published
2022
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38. Abstract IA023: Therapeutic efficacy of trametinib and ganitumab in RAS-mutated rhabdomyosarcoma

Author

Yohe, Marielle E., primary, Hebron, Katie E., additional, Wan, Xiaolin, additional, Roth, Jacob S., additional, Liewehr, David J., additional, Sealover, Nancy E., additional, Stauffer, Stacey, additional, Feehan-Nelson, Olivia, additional, Sun, Wenyue, additional, Isanogle, Kristine A., additional, Robinson, Christina M., additional, James, Amy, additional, Awasthi, Parirokh, additional, Shankarappa, Priya, additional, Liu, Xiaoling, additional, Lei, Haiyan, additional, Butcher, Donna, additional, Smith, Roberta, additional, Edmonson, Elijah F., additional, Chen, Jin-Qui, additional, Kedei, Noemi, additional, Peer, Cody S., additional, Shern, Jack F., additional, Figg, W. Douglas, additional, Chen, Lu, additional, Hall, Matthew D., additional, Difillipantonio, Simone, additional, Barr, Frederic G., additional, Kortum, Robert L., additional, Vaseva, Angelina V., additional, and Khan, Javed, additional

Published
2022
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41. Abstract 2152: TNIK, a novel activator of FAK and YAP signaling, is a therapeutic target in lung squamous cell carcinoma

Author

Torres-Ayuso, Pedro, primary, An, Elvira, additional, Nyswaner, Katherine M., additional, Ritt, Daniel A., additional, Specht, Suzanne I., additional, Das, Sudipto, additional, Andresson, Thorkell, additional, Robinson, Christina M., additional, Difilippantonio, Simone, additional, Karim, Baktiar O., additional, Turk, Benjamin E., additional, Morrison, Deborah K., additional, and Brognard, John, additional

Published
2022
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45. Serrated Polyp Yield at Colonoscopy in Patients with Positive FIT, Positive mt-sDNA, and Colonoscopy Only: Data from the New Hampshire Colonoscopy Registry.

Author

Anderson, Joseph C., Hisey, William M., Robinson, Christina M., Limburg, Paul J., Kneedler, Bonny L., and Butterly, Lynn F.

Abstract

Background: Stool-based screening with fecal immunochemical (FIT) or multitarget-stool DNA (mt-sDNA) tests is associated with increased colonoscopy polyp yield. mt-sDNA includes methylated markers, which improve detection of serrated polyps (SP) versus FIT. We compared SP detection in colonoscopies performed for positive FIT or mt-sDNA tests, as well as in colonoscopies without a preceding stool test, using the New Hampshire Colonoscopy Registry, a comprehensive statewide population-based registry. Methods: Across the three groups, we compared the frequency of clinically relevant SPs (CRSP: sessile SPs, hyperplastic polyps =10 mm, and traditional serrated adenomas). We also compared SP size, histology, number, and bulk (combined sizes). Results: Our sample included 560 mt-sDNA+ (age ± SD: 66.5 ± 7.9), 414 FIT+ (age ± SD: 66.3 ± 8.8), and 59,438 colonoscopy-only patients (age ± SD: 61.7 ± 8.0). mt-sDNA+ patients were more likely to have a higher yield of CRSPs and CRSP bulk than FIT+ (P < 0.0001) or colonoscopy-only patients (P < 0.0001). More mt-sDNA+ patients had CRSPs without large adenomas or colorectal cancers (17.9% vs. 9.9% of FIT+ and 8% of colonoscopy-only patients). After adjusting for synchronous large adenomas, colorectal cancers, and other risk factors, mt-sDNA+ patients were more likely (OR, 1.82; 95% CI, 1.18-2.85) than FIT+ patients to have CRSPs. Conclusions: mt-sDNA+ patients had a higher SP yield than FIT+ or colonoscopy-only patients, particularly in the absence of synchronous large adenomas or colorectal cancer. Impact: Our results suggest that screening with mt-sDNA tests could improve colorectal cancer screening by identifying more patients at increased risk from the serrated pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma

Author

Kowalczyk, Joshua T., primary, Wan, Xiaolin, additional, Hernandez, Edjay R., additional, Luo, Ruibai, additional, Lyons, Gaelyn C., additional, Wilson, Kelli M., additional, Gallardo, Devorah C., additional, Isanogle, Kristine A., additional, Robinson, Christina M., additional, Mendoza, Arnulfo, additional, Heske, Christine M., additional, Chen, Jinqui-Qiu, additional, Luo, Xiaoling, additional, Kelly, Alexander E., additional, Difilippantinio, Simone, additional, Robey, Robert W., additional, Thomas, Craig J., additional, Sackett, Dan L., additional, Morrison, Deborah K., additional, Randazzo, Paul A., additional, Jenkins, Lisa M. Miller, additional, and Yohe, Marielle E., additional

Published
2021
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50. TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Author

Torres-Ayuso, Pedro, primary, An, Elvira, additional, Nyswaner, Katherine M., additional, Bensen, Ryan C., additional, Ritt, Daniel A., additional, Specht, Suzanne I., additional, Das, Sudipto, additional, Andresson, Thorkell, additional, Cachau, Raul E., additional, Liang, Roger J., additional, Ries, Amy L., additional, Robinson, Christina M., additional, Difilippantonio, Simone, additional, Gouker, Brad, additional, Bassel, Laura, additional, Karim, Baktiar O., additional, Miller, Chad J., additional, Turk, Benjamin E., additional, Morrison, Deborah K., additional, and Brognard, John, additional

Published
2021
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