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2. Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Author

Reith, Christina, Preiss, David, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Harper, Charlie, Holland, Lisa, Wilson, Kate, Roddick, Alistair J, Cannon, Christopher P, Clarke, Robert, Colhoun, Helen M, Durrington, Paul N, Goto, Shinya, Hitman, Graham A, Hovingh, G Kees, Jukema, J Wouter, Koenig, Wolfgang, Marschner, Ian, Mihaylova, Borislava, Newman, Connie, Probsfield, Jeffrey L, Ridker, Paul M, Sabatine, Marc S, Sattar, Naveed, Schwartz, Gregory G, Tavazzi, Luigi, Tonkin, Andrew, Trompet, Stella, White, Harvey, Yusuf, Salim, Armitage, Jane, Keech, Anthony, Simes, John, Collins, Rory, Baigent, Colin, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, O'Connell, Rachel, Amarenco, Pierre, Arashi, Hiroyuki, Barter, Philip, Betteridge, D John, Blazing, Michael, Blauw, Gerard J, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Bulbulia, Richard, Byington, Robert, Clearfield, Michael, Cobbe, Stuart, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Fellström, Bengt, Flather, Marcus, Ford, Ian, Franzosi, Maria Grazia, Fuller, John, Furberg, Curt, Glynn, Robert, Goldbourt, Uri, Gordon, David, Gotto, Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Haynes, Richard, Holdaas, Hallvard, Hopewell, Jemma, Jardine, Alan, Kastelein, John JP, Kean, Sharon, Kearney, Patricia, Kitas, George, Kjekshus, John, Knatterud, Genell, Knopp, Robert H, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Robertson, Michele, Sacks, Frank, Schmieder, Roland, Serruys, Patrick, Sever, Peter, Shaw, John, Shepherd, James, Simpson, Lara, Sleight, Peter, Smeeth, Liam, Tobert, Jonathan, Tognoni, Gianni, Varigos, John, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Yamaguchi, Junichi, Young, Robin, and Zannad, Faiez

Published
2024
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3. The Impact of Ferric Derisomaltose on Cardiovascular and Noncardiovascular Events in Patients With Anemia, Iron Deficiency, and Heart Failure With Reduced Ejection Fraction

Author

Kalra, Paul, Cowan, Elena, Howe, Serena, Turner, Charlotte, Austin, Rosalynn, Lane, Rebeca, Rogers, Paula, Foley, Paul, Chandrasekaran, Badri, Fraile, Eva, Kyeremeh, Lynsey, Ahmed, Fozia, Petrie, Mark, McGregor, Lorraine, Osmanska, Joanna, Graham, Fraser, Lang, Ninian, Meyer, Barbara, Ahmad, Faheem, Squire, Iain, Fisher, Jude, Kalra, Philip, Summersgill, Christina, Adeniji, Katarzyna, Chinnadurai, Rajkumar, Ludman, Andrew, Massimo, Lisa, Hardman, Clare, Sykes, Daisy, Cowburn, Peter, Frank, Sarah, Smith, Simon, Japp, Alan, Anwar, Mohamed, Whittington, Beth, Seed, Alison, Ray, Robin, Sookhoo, Vennessa, Al-Mohammad, Abdallah, Middle, Janet, Housley, Kay, Clark, Andrew, Bulemfu, Jeanne, Critoph, Christopher, Chong, Victor, Wood, Stephen, Szwejkowski, Benjamin, Lang, Chim, Duff, Jackie, MacDonald, Susan, Schiff, Rebekah, Donnelly, Patrick, Nageh, Thuraia, Kunhunny, Swapna, Gardner, Roy, McAdam, Marion, McPherson, Elizabeth, Banerjee, Prithwish, Sear, Eleanor, Edwards, Nigel, Glover, Jason, Pellicori, Pierpaolo, Murphy, Clare, Cooke, Justin, Spencer, Charles, Francis, Mark, Matthews, Iain, McKie, Hayley, Marshall, Andrew, Large, Janet, Stratford, Jenny, Clifford, Piers, Tavares, Sara, Boos, Christopher, Keeling, Philip, Hughes, Debbie, Wong, Aaron, Jones, Deborah, James, Alex, Williams, Rhys, Leslie, Stephen, Finlayson, Jim, Hannah, Andrew, Campbell, Philip, Walsh, John, Quinn, Jane, Chapman, Callum, Piper, Susan, Gupta, Preeti, Sim, Victor, Knibbs, Lucy, Lyons, Kristopher, Dixon, Lana, Petrie, Colin, Wong, Yuk-ki, Labinjoh, Catherine, Duckett, Simon, Massey, Ian, Savage, Henry, Matias, Sofia, Ramirez, Jonaifah, Manisty, Charlotte, Hussain, Ifza, Sankaranarayanan, Rajiv, Davis, Gershan, McClure, Samuel, Baxter, John, Wicks, Eleanor, Sobolewska, Jolanta, Murphy, Jerry, Elzayat, Ahmed, Cooke, Alastair, Wright, Jay, Williams, Simon, Muthumala, Amal, Chaggar, Parminder, Ellis, Gethin, Welch, Mandie, Bulugahapitiya, Sudantha, Jackson, Thomas, Pakrashi, Tapesh, Bakhai, Ameet, Gamma, Reto, Ellery, Susan, Jenkins, Geraint, Nightingale, Angus, Thomson, Elizabeth, Ford, Ian, Robertson, Michele, Greenlaw, Nicola, Wetherall, Kirsty, Clarke, Ross, Graham, Christopher, Kean, Sharon, Stevenson, Alan, Wilson, Robbie, Boyle, Sarah, McHugh, John, Hall, Lisa, Woollard, Joanne, Brunton, Claire, Dinnett, Eleanor, Reid, Amanda, Nicholls, Jill, Cunnington, Anna, Douglas, Elizabeth, Fegen, Margaret, Jones, Marc, McGowan, Sheila, Ross, Barbara, Sandu, Pamela, Surtees, Pamela, Stuart, Debra, Cleland, John G.F., Ahmed, Fozia Z., Cowburn, Peter J., Critoph, Chris, Kalra, Philip A., Lane, Rebecca E., Petrie, Mark C., Robertson, Michelle, and Kalra, Paul R.

Published
2024
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4. Geophysical monitoring using active seismic techniques at the Citronelle Alabama CO2 storage demonstration site

Author

Trautz, Robert, Daley, Thomas, Miller, Douglas, Robertson, Michele, Koperna, George, and Riestenberg, David

Subjects
Earth Sciences, Engineering, Geology, Environmental Sciences, Energy, Earth sciences, Environmental sciences
Abstract

Between August 2012 and September 2014, about 114,000 metric tonnes of CO2 was captured from the coal-fired Plant Barry Power Station at Bucks Alabama and injected into the Paluxy Formation above the oil pool in the southeast unit of the Citronelle Oilfield. Various monitoring methods were deployed at land surface and in project wells to measure system performance, comply with permit requirements and test new and innovative monitoring tools. The monitoring program relied heavily on active seismic methods for subsurface imaging of geologic structure and time-lapse seismic techniques to track the CO2 migration in the injection interval. Both conventional geophone/hydrophone and fiber-optic based Distributed Acoustic Sensing (DAS) arrays were deployed and tested, allowing a side by side comparison of the equipment and techniques. Geophysical imaging of the subsurface was successful using DAS in the offset vertical seismic profile (OVSP) survey configuration. A high resolution OVSP image of the subsurface was obtained in 2014 with DAS, which exceeded project expectations in comparison to a lower resolution image obtained in 2012 using a conventional 80-level geophone array. A time-lapse image of the redistribution of CO2 after injection ended in September 2014 was obtained with two DAS OVSP surveys from June 2014 and December 2015, thus successfully demonstrating its proof-of-concept. Unfortunately, a pre-injection baseline survey with DAS, which was in its initial stage of technology development in 2012, did not have sufficient quality for use, making it difficult to interpret the acquired DAS time-lapse difference. Additional research in this area has since demonstrated the utility of time-lapse DAS OVSP. DAS data were also acquired during a cross-well seismic survey conducted in 2014. Unfortunately, the DAS technique was not success in the cross-well survey configuration because the system noise level was too high in the crosswell frequency output range (100–1200 Hz) of the piezoelectric source (increasing by a factor of ten compared to VSP frequency band). Additionally, the cross-well geometry causes sub-horizontal (broadside) incidence on the vertical DAS fiber cable, which is known to be problematic. Current research is focused on improving the DAS cable response to broadside acoustic energy. Time-lapse seismic surveys using commercially available conventional arrays were also acquired. In contrast to the DAS acquired data, the cross-well seismic results obtained with the conventional array was highly successful and clearly showed the CO2 remained in zone at the end of injection. Time-lapse differencing of the OSVP surveys acquired with the conventional arrays proved to be inconclusive. Changes in wellbore conditions between surveys and unavoidable changes in equipment (the array used for the baseline survey was retired) affected data quality, making it difficult to interpret the OVSP results.

Published
2020

5. Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial

Author

Dawson, Jesse, Robertson, Michele, Dickie, David Alexander, Bath, Phillip, Forbes, Kirsten, Quinn, Terence, Broomfield, Niall M., Dani, Krishna, Doney, Alex, Houston, Graeme, Lees, Kennedy R., Muir, Keith W., Struthers, Allan, Walters, Matthew, Barber, Mark, Bhalla, Ajay, Cameron, Alan, Dyker, Alexander, Guyler, Paul, Hassan, Ahamad, Kearney, Mark T., Keegan, Breffni, Lakshmanan, Sekaran, Macleod, Mary Joan, Randall, Marc, Shaw, Louise, Subramanian, Ganesh, Werring, David, and McConnachie, Alex

Published
2023
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6. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

Author

Kalra, Paul R, Cleland, John GF, Petrie, Mark C, Thomson, Elizabeth A, Kalra, Philip A, Squire, Iain B, Ahmed, Fozia Z, Al-Mohammad, Abdallah, Cowburn, Peter J, Foley, Paul WX, Graham, Fraser J, Japp, Alan G, Lane, Rebecca E, Lang, Ninian N, Ludman, Andrew J, Macdougall, Iain C, Pellicori, Pierpaolo, Ray, Robin, Robertson, Michele, Seed, Alison, Ford, Ian, Boon, Nicholas, Amoils, Shannon, Chapman, Callum, Diness, Thomas G, McMurray, John, Mindham, Richard, Sandu, Pamela, Strom, Claes C, Travers, Maureen, Wilcox, Robert, Struthers, Allan, Mark, Patrick, Weir, Christopher, Cowan, Elena, Turner, Charlotte, Austin, Rosalynn, Rogers, Paula, Chandrasekaran, Badri, Fraile, Eva, Kyeremeh, Lynsey, McGregor, Lorraine, Osmanska, Joanna, Meyer, Barbara, Ahmad, Faheem, Fisher, Jude, Summersgill, Christina, Adeniji, Katarzyna, Chinnadurai, Rajkumar, Massimo, Lisa, Hardman, Clare, Sykes, Daisy, Frank, Sarah, Smith, Simon, Anwar, Mohamed, Whittington, Beth, Sookhoo, Vennessa, Lyons, Sinead, Middle, Janet, Housley, Kay, Clark, Andrew, Bulemfu, Jeanne, Critoph, Christopher, Chong, Victor, Wood, Stephen, Szwejkowski, Benjamin, Lang, Chim, Duff, Jackie, MacDonald, Susan, Schiff, Rebekah, Donnelly, Patrick, Nageh, Thuraia, Kunhunny, Swapna, Gardner, Roy, McAdam, Marion, McPherson, Elizabeth, Banerjee, Prithwish, Sear, Eleanor, Edwards, Nigel, Glover, Jason, Murphy, Clare, Cooke, Justin, Spencer, Charles, Francis, Mark, Matthews, Iain, McKie, Hayley, Marshall, Andrew, Large, Janet, Stratford, Jenny, Clifford, Piers, Boos, Christopher, Keeling, Philip, Hughes, Debbie, Wong, Aaron, Jones, Deborah, James, Alex, Williams, Rhys, Leslie, Stephen, Finlayson, Jim, Hannah, Andrew, Campbell, Philip, Walsh, John, Quinn, Jane, Piper, Susan, Patale, Sheetal, Gupta, Preeti, Sim, Victor, Knibbs, Lucy, Lyons, Kristopher, Dixon, Lana, Petrie, Colin, Wong, Yuk-ki, Labinjoh, Catherine, Duckett, Simon, Massey, Ian, Savage, Henry, Matias, Sofia, Ramirez, Jonaifah, Manisty, Charlotte, Hussain, Ifza, Sankaranarayanan, Rajiv, Davis, Gershan, McClure, Samuel, Baxter, John, Wicks, Eleanor, Sobolewska, Jolanta, Murphy, Jerry, Elzayat, Ahmed, Cooke, Alastair, Wright, Jay, Williams, Simon, Muthumala, Amal, Chaggar, Parminder, Webber, Sue, Ellis, Gethin, Welch, Mandie, Bulugahapitiya, Sudantha, Jackson, Thomas, Pakrashi, Tapesh, Bakhai, Ameet, Krishnamurthy, Vinodh, Gamma, Reto, Ellery, Susan, Jenkins, Geraint, Thomas, Gladdys, Nightingale, Angus, Greenlaw, Nicola, Wetherall, Kirsty, Clarke, Ross, Graham, Christopher, Kean, Sharon, Stevenson, Alan, Wilson, Robbie, Boyle, Sarah, McHugh, John, Hall, Lisa, Woollard, Joanne, Brunton, Claire, Dinnett, Eleanor, Reid, Amanda, Howe, Serena, Nicholls, Jill, Cunnington, Anna, Douglas, Elizabeth, Fegen, Margaret, Jones, Marc, McGowan, Sheila, Ross, Barbara, Surtees, Pamela, Stuart, Debra, Cleland, John G F, and Foley, Paul W X

Published
2022
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7. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

Author

Reith, Christina, Baigent, Colin, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Holland, Lisa, Wilson, Kate, Armitage, Jane, Harper, Charlie, Preiss, David, Roddick, Alistair, Keech, Anthony, Simes, John, Collins, Rory, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, Mihaylova, Borislava, O'Connell, Rachel, Amarenco, Pierre, Barter, Philip, Betteridge (deceased), D John, Blazing, Michael, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Cannon, Christopher P, Clearfield, Michael, Cobbe, Stuart, Colhoun, Helen M, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Durrington, Paul N, Fellström, Bengt, Ford, Ian, Franzosi, Maria Grazia, Fuller (deceased), John, Furberg, Curt, Glynn, Robert, Gordon, David, Gotto Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Hitman, Graham A, Holdaas (deceased), Hallvard, Jardine, Alan, Jukema, J Wouter, Kastelein, John JP, Kean, Sharon, Kjekshus, John, Knatterud (deceased), Genell, Knopp (deceased), Robert H, Koenig, Wolfgang, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Marschner, Ian, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Ridker, Paul M, Robertson, Michele, Sacks, Frank, Sattar, Naveed, Schmieder, Roland, Serruys, Patrick W, Sever, Peter, Shaw (deceased), John, Shepherd (deceased), James, Simpson, Lara, Sleight (deceased), Peter, Tavazzi, Luigi, Tognoni, Gianni, Tonkin, Andrew, Trompet, Stella, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, White, Harvey, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Young, Robin, Yusuf, Salim, Zannad, Faiez, Arashi, Hiroyuki, Byington, Robert, Clarke, Robert, Flather, Marcus, Goldbourt, Uri, Goto, Shinya, Hopewell, Jemma, Hovingh, Kees, Kearney, Patricia, Kitas, George, Newman, Connie, Sabatine, Marc S, Schwartz, Greg, Smeeth, Liam, Tobert, Jonathan, Varigos, John, and Yamaguchi, Junichi

Published
2022
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8. An Analysis of Vascular Access Thrombosis Events From the Proactive IV irOn Therapy in hemodiALysis Patients Trial

Author

Winnett, Georgia, Akbani, Habib, Winearls, Christopher, Wessels, Julie, Ayub, Waqar, Connor, Andrew, Brown, Alison, Moriarty, Jim, Chowdury, Paramit, Griffiths, Megan, Dasgupta, Indranil, Bhandari, Sunil, Doulton, Timothy, Macdougall, Iain, Barratt, Jonathan, Vilar, Enric, Mitra, Sandip, Ramakrishna, Babu, Nicholas, Johann, Ross, Calum, Khwaja, Arif, Hall, Matt, Kirk, Adam, Smith, Stuart, Jesky, Mark, Day, Clara, Alchi, Bassam, Stratton, Jon, Clarke, Helen, Walsh, Stephen, Brown, Rebecca, McCafferty, Kieran, Solomon, Laurie, Ramadoss, Suresh, Basanyake, Kolitha, Lawman, Sarah, Kalra, Philip, Balasubramaniam, Gowrie, Power, Albert, Banerjee, Debasish, Swift, Pauline, Wellberry-Smith, Matt, Goldsmith, Christopher, Ledson, Thomas, Mikhail, Ashraf, Benzimra, Ruth, Bell, Samira, Severn, Alison, Neary, John, Doyle, Arthur, Thomson, Peter, Shivashankar, Girish, Bolton, Stephanie, Quinn, Michael, Maxwell, Peter, Harty, John, Ford, Ian, Anker, Stefan, Farrington, Kenneth, McMurray, John, Tomson, Charles, Wheeler, David, Petrie, Mark, Connolly, Eugene, Jhund, Pardeep, MacDonald, Michael, Mark, Patrick, Walters, Matthew, Peacock, Janet, Isles, Chris, Reddan, Donal, Aziz, Jane, Boyle, Sarah, Burton, Claire, Clarke, Ross, Dinnett, Eleanor, Hillen, Neil, Kean, Sharon, Kerr, Claire, Murray, Heather, Reid, Amanda, Wetherall, Kirsty, Wilson, Robbie, White, Claire, Andani, Sadiq, Thomson, Peter C., Mark, Patrick B., Robertson, Michele, Anker, Stefan D., Jardine, Alan G., Kalra, Philip A., Wheeler, David C., Winearls, Christopher G., and Macdougall, Iain C.

Published
2022
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11. Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke

Author

Dawson, Jesse, Pierce, David, Dixit, Anand, Kimberley, Teresa J, Robertson, Michele, Tarver, Brent, Hilmi, Omar, McLean, John, Forbes, Kirsten, Kilgard, Michael P, Rennaker, Robert L, Cramer, Steven C, Walters, Matthew, and Engineer, Navzer

Subjects
Physical Rehabilitation, Stroke, Rehabilitation, Neurosciences, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Adult, Aged, Brain Ischemia, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Muscle Weakness, Patient Safety, Pilot Projects, Recovery of Function, Single-Blind Method, Stroke Rehabilitation, Treatment Outcome, Upper Extremity, Vagus Nerve Stimulation, deglutition disorders, intention to treat analysis, rehabilitation, stroke, vagus nerve, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeRecent animal studies demonstrate that vagus nerve stimulation (VNS) paired with movement induces movement-specific plasticity in motor cortex and improves forelimb function after stroke. We conducted a randomized controlled clinical pilot study of VNS paired with rehabilitation on upper-limb function after ischemic stroke.MethodsTwenty-one participants with ischemic stroke >6 months before and moderate to severe upper-limb impairment were randomized to VNS plus rehabilitation or rehabilitation alone. Rehabilitation consisted of three 2-hour sessions per week for 6 weeks, each involving >400 movement trials. In the VNS group, movements were paired with 0.5-second VNS. The primary objective was to assess safety and feasibility. Secondary end points included change in upper-limb measures (including the Fugl-Meyer Assessment-Upper Extremity).ResultsNine participants were randomized to VNS plus rehabilitation and 11 to rehabilitation alone. There were no serious adverse device effects. One patient had transient vocal cord palsy and dysphagia after implantation. Five had minor adverse device effects including nausea and taste disturbance on the evening of therapy. In the intention-to-treat analysis, the change in Fugl-Meyer Assessment-Upper Extremity scores was not significantly different (between-group difference, 5.7 points; 95% confidence interval, -0.4 to 11.8). In the per-protocol analysis, there was a significant difference in change in Fugl-Meyer Assessment-Upper Extremity score (between-group difference, 6.5 points; 95% confidence interval, 0.4 to 12.6).ConclusionsThis study suggests that VNS paired with rehabilitation is feasible and has not raised safety concerns. Additional studies of VNS in adults with chronic stroke will now be performed.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01669161.

Published
2016

12. Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial.

Author

Cleland, John G F, Kalra, Philip A, Pellicori, Pierpaolo, Graham, Fraser J, Foley, Paul W X, Squire, Iain B, Cowburn, Peter J, Seed, Alison, Clark, Andrew L, Szwejkowski, Ben, Banerjee, Prithwish, Cooke, Justin, Francis, Mark, Clifford, Piers, Wong, Aaron, Petrie, Colin, McMurray, John J V, Thomson, Elizabeth A, Wetherall, Kirsty, and Robertson, Michele

Subjects
IRON deficiency, HEART failure, HEART failure patients, FERRITIN, TRANSFERRIN
Abstract

Background and Aims What is the relationship between blood tests for iron deficiency, including anaemia, and the response to intravenous iron in patients with heart failure? Methods In the IRONMAN trial, 1137 patients with heart failure, ejection fraction ≤ 45%, and either serum ferritin < 100 µg/L or transferrin saturation (TSAT) < 20% were randomized to intravenous ferric derisomaltose (FDI) or usual care. Relationships were investigated between baseline anaemia severity, ferritin and TSAT, to changes in haemoglobin from baseline to 4 months, Minnesota Living with Heart Failure (MLwHF) score and 6-minute walk distance achieved at 4 months, and clinical events, including heart failure hospitalization (recurrent) or cardiovascular death. Results The rise in haemoglobin after administering FDI, adjusted for usual care, was greater for lower baseline TSAT (P interaction <.0001) and ferritin (P interaction =.028) and more severe anaemia (P interaction =.014). MLwHF scores at 4 months were somewhat lower (better) with FDI for more anaemic patients (overall P interaction =.14; physical P interaction =.085; emotional P interaction =.043) but were not related to baseline TSAT or ferritin. Blood tests did not predict difference in achieved walking distance for those randomized to FDI compared to control. The absence of anaemia or a TSAT ≥ 20% was associated with lower event rates and little evidence of benefit from FDI. More severe anaemia or TSAT < 20%, especially when ferritin was ≥100 µg/L, was associated with higher event rates and greater absolute reductions in events with FDI, albeit not statistically significant. Conclusions This hypothesis-generating analysis suggests that anaemia or TSAT < 20% with ferritin > 100 µg/L might identify patients with heart failure who obtain greater benefit from intravenous iron. This interpretation requires confirmation. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Allopurinol and Blood Pressure Variability Following Ischemic Stroke and Transient Ischemic Attack: A Secondary Analysis of XILO-FIST

Author

MacDonald, Alexander Stuart, primary, Robertson, Michele, additional, Dickie, David Alexander, additional, Bath, Phillip, additional, Forbes, Kirsten, additional, Quinn, Terence, additional, Broomfield, Niall M, additional, Dani, Krishna, additional, Doney, Alex, additional, Muir, Keith W, additional, Struthers, Allan, additional, Walters, Matthew, additional, Barber, Mark, additional, Bhalla, Ajay, additional, Cameron, Alan, additional, Dyker, Alexander, additional, Guyler, Paul, additional, Hassan, Ahamad, additional, Kearney, Mark, additional, Keegan, Breffni, additional, Sekaran, Lakshmanan, additional, Macleod, Mary Joan, additional, Randall, Marc, additional, Shaw, Louise, additional, Subramanian, Ganesh, additional, Werring, David, additional, McConnachie, Alex, additional, and Dawson, Jesse, additional

Published
2023
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15. 134 Effect of intravenous iron (ferric derisomaltose) on haemoglobin and clinical events according to age in patients with heart failure and iron deficiency in a randomised trial (ironman)

Author

Squire, Iain, primary, Cowburn, Peter, additional, Lang, Ninian, additional, Critoph, Chris, additional, Schiff, Rebekah, additional, Szwejkowski, Ben, additional, Petrie, Mark, additional, Kalra, Paul, additional, Ford, Ian, additional, Ray, Robin, additional, Donnelly, Patrick, additional, Clelland, John GF, additional, Robertson, Michele, additional, Thomson, Elizabeth, additional, Banerjee, Prithwish, additional, and Nageh, Thuraia, additional

Published
2023
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16. 136 Risk of infection with ferric derisomaltose compared to standard of care in patients with heart failure and iron deficiency in the uk: a prespecified analysis of the ironman trial

Author

Foley, Paul, primary, Kalra, Paul, additional, Lane, Rebecca, additional, Petrie, Mark, additional, Cowburn, Peter, additional, Thomson, Elizabeth, additional, Critoph, Christopher, additional, Ray, Robin, additional, Robertson, Michele, additional, Clark, Andrew, additional, Ford, Ian, additional, Clelland, John GF, additional, and Squire, Iain, additional

Published
2023
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17. 144 Effect of intravenous ferric derisomaltose in women compared to men with heart failure in the ironman randomised trial

Author

Seed, Alison, primary, Pellicori, Pierpalo, additional, Kalra, Paul, additional, Glover, Jason, additional, Japp, Alan, additional, Lane, Rebecca, additional, Ludman, Andrew, additional, Cooke, Justin, additional, Al - Mohammad, Abdallah, additional, Robertson, Michele, additional, Chong, Victor, additional, Clelland, John GF, additional, and Ford, Ian, additional

Published
2023
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22. An analysis of vascular access thrombosis events from the Proactive IV Iron Therapy in Hemodialysis Patients (PIVOTAL) trial

Author

Thomson, Peter C., Mark, Patrick B., Robertson, Michele, White, Claire, Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Jardine, Alan G., Kalra, Philip A., McMurray, John, Reddan, Donal, Wheeler, David C., Winearls, Christopher G., Ford, Ian, and Macdougall, Iain C.

Abstract

Introduction:\ud \ud Treatment of anaemia in dialysis patients has been associated with increased risk of vascular access thrombosis (VAT). PIVOTAL was a clinical trial of proactive compared to reactive intravenous iron therapy in patients requiring haemodialysis. We analysed the trial data to determine whether randomised treatment arm, alongside other clinical and laboratory variables, independently associated with VAT.\ud \ud Methods:\ud \ud In PIVOTAL, 2141 adult patients were randomised. The type of vascular access (AVF, AVG or CVC) was recorded at baseline and every month after randomization. The associations between clinical and laboratory data and first VAT were examined in a multivariate analysis.\ud \ud Results:\ud \ud 480 (22.4%) participants experienced VAT over a median 2.1 years follow up. In multivariable analyses, treatment arm (Proactive v Reactive) was not an independent predictor of VAT (HR 1.13, p=0.18). Diabetic kidney disease (HR 1.45, p

Published
2022

23. Rationale and design of a randomised trial of intravenous iron in patients with heart failure

Author

Kalra, Paul R, primary, Cleland, John GF, additional, Petrie, Mark C, additional, Ahmed, Fozia Z, additional, Foley, Paul WX, additional, Kalra, Philip A, additional, Lang, Ninian N, additional, Lane, Rebecca E, additional, Macdougall, Iain C, additional, Pellicori, Pierpaolo, additional, Pope, Michael T B, additional, Robertson, Michele, additional, Squire, Iain B, additional, Thomson, Elizabeth A, additional, and Ford, Ian, additional

Published
2022
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24. An Analysis of Vascular Access Thrombosis Events From the Proactive IV irOn Therapy in hemodiALysis Patients Trial

Author

Thomson, Peter C., primary, Mark, Patrick B., additional, Robertson, Michele, additional, White, Claire, additional, Anker, Stefan D., additional, Bhandari, Sunil, additional, Farrington, Kenneth, additional, Jardine, Alan G., additional, Kalra, Philip A., additional, McMurray, John, additional, Reddan, Donal, additional, Wheeler, David C., additional, Winearls, Christopher G., additional, Ford, Ian, additional, Macdougall, Iain C., additional, Winnett, Georgia, additional, Akbani, Habib, additional, Winearls, Christopher, additional, Wessels, Julie, additional, Ayub, Waqar, additional, Connor, Andrew, additional, Brown, Alison, additional, Moriarty, Jim, additional, Chowdury, Paramit, additional, Griffiths, Megan, additional, Dasgupta, Indranil, additional, Doulton, Timothy, additional, Macdougall, Iain, additional, Barratt, Jonathan, additional, Vilar, Enric, additional, Mitra, Sandip, additional, Ramakrishna, Babu, additional, Nicholas, Johann, additional, Ross, Calum, additional, Khwaja, Arif, additional, Hall, Matt, additional, Kirk, Adam, additional, Smith, Stuart, additional, Jesky, Mark, additional, Day, Clara, additional, Alchi, Bassam, additional, Stratton, Jon, additional, Clarke, Helen, additional, Walsh, Stephen, additional, Brown, Rebecca, additional, McCafferty, Kieran, additional, Solomon, Laurie, additional, Ramadoss, Suresh, additional, Basanyake, Kolitha, additional, Lawman, Sarah, additional, Kalra, Philip, additional, Balasubramaniam, Gowrie, additional, Power, Albert, additional, Banerjee, Debasish, additional, Swift, Pauline, additional, Wellberry-Smith, Matt, additional, Goldsmith, Christopher, additional, Ledson, Thomas, additional, Mikhail, Ashraf, additional, Benzimra, Ruth, additional, Bell, Samira, additional, Severn, Alison, additional, Neary, John, additional, Doyle, Arthur, additional, Thomson, Peter, additional, Shivashankar, Girish, additional, Bolton, Stephanie, additional, Quinn, Michael, additional, Maxwell, Peter, additional, Harty, John, additional, Anker, Stefan, additional, Tomson, Charles, additional, Wheeler, David, additional, Petrie, Mark, additional, Connolly, Eugene, additional, Jhund, Pardeep, additional, MacDonald, Michael, additional, Mark, Patrick, additional, Walters, Matthew, additional, Peacock, Janet, additional, Isles, Chris, additional, Aziz, Jane, additional, Boyle, Sarah, additional, Burton, Claire, additional, Clarke, Ross, additional, Dinnett, Eleanor, additional, Hillen, Neil, additional, Kean, Sharon, additional, Kerr, Claire, additional, Murray, Heather, additional, Reid, Amanda, additional, Wetherall, Kirsty, additional, Wilson, Robbie, additional, and Andani, Sadiq, additional

Published
2022
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25. Abstract 18347: Prognostic Significance of Activation Delay by Cross Correlation Analysis Using Tissue Doppler Imaging in Patients With Heart Failure and Narrow QRS Duration; an Echocardiography Guided Cardiac Resynchronization Therapy (Echo-CRT) Trial Substudy of Patients Not Randomized to CRT

Author

Tayal, Bhupendar, Gorcsan 3rd, John, Bax, Jeroen, Risum, Niels, Olsen, Niels Thue, Singh, Jagmeet P, Abraham, William T, Borer, Jeffrey S, Dickstein, Kenneth, Gras, Daniel, Krum, Henry, Brugada, Josep, Robertson, Michele, Ford, Ian, Holzmeister, Johannes, Ruschitzka, Frank, and Sogaard, Peter

Published
2017

26. Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above: Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational Follow-Up

Author

Vallejo-Vaz, Antonio J., Robertson, Michele, Catapano, Alberico L., Watts, Gerald F., Kastelein, John J., Packard, Chris J., Ford, Ian, and Ray, Kausik K.

Published
2017
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28. Recent Cocaine and Crack Use Among New Drug Treatment Clients in Scotland

Author

Neale, Joanne and Robertson, Michele

Abstract

UK and US literature indicate that cocaine and crack users experience multiple problems and poor treatment outcomes (Gossop et al., 2002 , 2003 ). Using data collected as part of a Scottish national evaluation of drug treatment effectiveness, this paper: (i) provides information on the nature and extent of recent cocaine and crack use among 585 new drug treatment clients; and (ii) investigates whether those who had recently used cocaine and/or crack comprised distinct treatment subpopulations. Data were analysed using chi-square tests of association (or Fisher's exact tests), ANOVA and stepwise multivariate logistic regression. Although more respondents than anticipated reported cocaine and/or crack use, consumption was generally infrequent and not considered problematic. Recent cocaine and/or crack users were more likely than other respondents to have taken non-prescribed benzodiazepines in the last 90 days; be seeking residential treatment; have recently committed acquisitive crime; have been robbed, attacked or assaulted in the last six months; have a spouse or partner; and have a longer history of problematic drug use. In contrast, few differences between those who had recently used "cocaine only", "crack only", and "both cocaine and crack" were found. It is concluded that drug agency staff in Scotland must be alert to, and have the resources and training to deal with, the complex needs of the increasing numbers of cocaine and crack users approaching their services.

Published
2004

29. MO534: Associations of Haemoglobin Values and Rate of Changes With Mace in the ASCEND-D Randomised Clinical Trial

Author

Obrador, Gregorio, primary, Macdougall, Iain, additional, Johansen, Kirsten, additional, Jha, Vivekanand, additional, Correa-Rotter, Ricardo, additional, Del Vecchio, Lucia, additional, Cases Amenos, Aleix, additional, Robertson, Michele, additional, Mallett, Steve, additional, K. Bailey, Christine, additional, Cobitz, Alexander, additional, and K. Singh, Ajay, additional

Published
2022
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30. MO535: Associations of Haemoglobin Values and Rate of Changes With MACE in the ASCEND-ND Randomised Clinical Trial

Author

K. Singh, Ajay, primary, Macdougall, Iain, additional, Johansen, Kirsten, additional, Jha, Vivekanand, additional, Correa-Rotter, Ricardo, additional, Del Vecchio, Lucia, additional, Cases Amenos, Aleix, additional, Robertson, Michele, additional, Mallett, Steve, additional, K. Bailey, Christine, additional, Cobitz, Alexander, additional, and Obrador, Gregorio, additional

Published
2022
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31. High-dose intravenous iron reduces myocardial infarction in patients on haemodialysis

Author

Petrie, Mark C., Jhund, Pardeep S., Connolly, Eugene, Mark, Patrick B., MacDonald, Michael R., Robertson, Michele, Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Kalra, Philip A., Wheeler, David C., Tomson, Charles R.V., Ford, Ian, McMurray, John J.V., and Macdougall, Iain C.

Abstract

Aims: \ud To investigate the effect of high-dose iron vs. low-dose intravenous (IV) iron on myocardial infarction (MI) in patients on maintenance haemodialysis.\ud \ud Methods and results: \ud This was a pre-specified analysis of secondary endpoints of the Proactive IV Iron Therapy in Hemodialysis Patients trial (PIVOTAL) randomized, controlled clinical trial. Adults who had started haemodialysis within the previous year, who had a ferritin concentration

Published
2021

33. Xanthine Oxidase Inhibition And&nbsp;White Matter Hyperintensity Progression&nbsp;Following Ischaemic Stroke and Transient Ischaemic Attack; The XILO-FIST Randomised Placebo Controlled Trial

Author

Dawson, Jesse, primary, Robertson, Michele, additional, Dickie, David Alexander, additional, Bath, Phillip, additional, Forbes, Kirsten, additional, Quinn, Terence, additional, Broomfield, Niall, additional, Dani, Krishna, additional, Doney, Alex, additional, Houston, Graeme, additional, Lees, Kennedy, additional, Muir, Keith, additional, Struthers, Allan, additional, Walters, Matthew, additional, Barber, Mark, additional, Balla, Ajay, additional, Cameron, Alan, additional, Dyker, Alexander, additional, Guyler, Paul, additional, Hassan, Ahamad, additional, Kearney, Mark, additional, Keegan, Breffni, additional, Lakshmanan, Sekaran, additional, Macleod, Mary J., additional, Randall, Marc, additional, Shaw, Louise, additional, Subramanian, Ganesh, additional, Werring, David J., additional, and McConnachie, Alex, additional

Published
2022
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35. Heart failure hospitalization in adults receiving maintenance hemodialysis and effect of intravenous iron therapy: A report from PIVOTAL

Author

Jhund, Pardeep S., Petrie, Mark C., Robertson, Michele, Mark, Patrick B., MacDonald, Michael R., Connolly, Eugene, Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Kalra, Philip A., Wheeler, David C., Tomson, Charles R.V., Ford, Ian, McMurray, John J.V., and Macdougall, Iain C.

Subjects
R1
Abstract

Objectives:\ud \ud The study sought to examine the effect of intravenous iron on heart failure events in hemodialysis patients.\ud \ud Background:\ud \ud Heart failure is a common and deadly complication in patients receiving hemodialysis and is difficult to diagnose and treat.\ud \ud Methods:\ud \ud The study analyzed heart failure events in the PIVOTAL (Proactive IV Iron Therapy in Hemodialysis Patients) trial, which compared intravenous iron administered proactively in a high-dose regimen with a low-dose regimen administered reactively. Heart failure hospitalization was an adjudicated outcome, a component of the primary composite outcome, and a prespecified secondary endpoint in the trial.\ud \ud Results:\ud \ud Overall, 2,141 participants were followed for a median of 2.1 years. A first fatal or nonfatal heart failure event occurred in 51 (4.7%) of 1,093 patients in the high-dose iron group and in 70 (6.7%) of 1,048 patients in the low-dose group (HR: 0.66; 95% CI: 0.46-0.94; P = 0.023). There was a total of 63 heart failure events (including first and recurrent events) in the high-dose iron group and 98 in the low-dose group, giving a rate ratio of 0.59 (95% CI: 0.40-0.87; P = 0.0084). Most patients presented with pulmonary edema and were mainly treated by mechanical removal of fluid. History of heart failure and diabetes were independent predictors of a heart failure event.\ud \ud Cconclusion:\ud \ud Compared with a lower-dose regimen, high-dose intravenous iron decreased the occurrence of first and recurrent heart failure events in patients undergoing hemodialysis, with large relative and absolute risk reductions. (UK Multicentre Open-label Randomised Controlled Trial Of IV Iron Therapy In Incident Haemodialysis Patients; 2013-002267-25).

Published
2021

36. Stroke in Hemodialysis Patients Randomized to Different Intravenous Iron Strategies: A Prespecified Analysis from the PIVOTAL Trial

Author

Mark, Patrick B., primary, Jhund, Pardeep S., additional, Walters, Matthew R., additional, Petrie, Mark C., additional, Power, Albert, additional, White, Claire, additional, Robertson, Michele, additional, Connolly, Eugene, additional, Anker, Stefan D., additional, Bhandari, Sunil, additional, Farrington, Kenneth, additional, Kalra, Philip A., additional, Tomson, Charles R.V., additional, Wheeler, David C., additional, Winearls, Christopher G., additional, McMurray, John J.V., additional, Macdougall, Iain C., additional, and Ford, Ian, additional

Published
2021
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44. Assessing Risk Prediction Models Using Individual Participant Data From Multiple Studies

Author

Pennells, Lisa, Kaptoge, Stephen, White, Ian R., Thompson, Simon G., Wood, Angela M., Tipping, Robert W., Folsom, Aaron R., Couper, David J., Ballantyne, Christie M., Coresh, Josef, Goya Wannamethee, S., Morris, Richard W., Kiechl, Stefan, Willeit, Johann, Willeit, Peter, Schett, Georg, Ebrahim, Shah, Lawlor, Debbie A., Yarnell, John W., Gallacher, John, Cushman, Mary, Psaty, Bruce M., Tracy, Russ, Tybjærg-Hansen, Anne, Price, Jackie F., Lee, Amanda J., McLachlan, Stela, Khaw, Kay-Tee, Wareham, Nicholas J., Brenner, Hermann, Schöttker, Ben, Müller, Heiko, Jansson, Jan-Håkan, Wennberg, Patrik, Salomaa, Veikko, Harald, Kennet, Jousilahti, Pekka, Vartiainen, Erkki, Woodward, Mark, DʼAgostino, Ralph B., Bladbjerg, Else-Marie, Jørgensen, Torben, Kiyohara, Yutaka, Arima, Hisatomi, Doi, Yasufumi, Ninomiya, Toshiharu, Dekker, Jacqueline M., Nijpels, Giel, Stehouwer, Coen D. A., Kauhanen, Jussi, Salonen, Jukka T., Meade, Tom W., Cooper, Jackie A., Cushman, Mary, Folsom, Aaron R., Psaty, Bruce M., Shea, Steven, Döring, Angela, Kuller, Lewis H., Grandits, Greg, Gillum, Richard F., Mussolino, Michael, Rimm, Eric B., Hankinson, Sue E., Manson, JoAnn E., Pai, Jennifer K., Kirkland, Susan, Shaffer, Jonathan A., Shimbo, Daichi, Bakker, Stephan J. L., Gansevoort, Ron T., Hillege, Hans L., Amouyel, Philippe, Arveiler, Dominique, Evans, Alun, Ferrières, Jean, Sattar, Naveed, Westendorp, Rudi G., Buckley, Brendan M., Cantin, Bernard, Lamarche, Benoît, Barrett-Connor, Elizabeth, Wingard, Deborah L., Bettencourt, Richele, Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Kavousi, Maryam, Witteman, Jacqueline C., Hofman, Albert, Franco, Oscar H., Howard, Barbara V., Zhang, Ying, Best, Lyle, Umans, Jason G., Onat, Altan, Sundström, Johan, Michael Gaziano, J., Stampfer, Meir, Ridker, Paul M., Michael Gaziano, J., Ridker, Paul M., Marmot, Michael, Clarke, Robert, Collins, Rory, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Kivimäki, Mika, Ridker, Paul M., Buring, Julie, Cook, Nancy, Ford, Ian, Shepherd, James, Cobbe, Stuart M., Robertson, Michele, Walker, Matthew, Watson, Sarah, Alexander, Myriam, Butterworth, Adam S., Angelantonio, Emanuele Di, Gao, Pei, Haycock, Philip, Kaptoge, Stephen, Pennells, Lisa, Thompson, Simon G., Walker, Matthew, Watson, Sarah, White, Ian R., Wood, Angela M., Wormser, David, and Danesh, John

Published
2014
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46. Effects of carvedilol early after myocardial infarction: Analysis of the first 30 days in Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction (CAPRICORN)

Author

Fonarow, Gregg C., Lukas, Mary Ann, Robertson, Michele, Colucci, Wilson S., and Dargie, Henry J.

Subjects
Heart attack -- Analysis, Lactate dehydrogenase -- Analysis, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.06.002 Byline: Gregg C. Fonarow (a), Mary Ann Lukas (b), Michele Robertson (c), Wilson S. Colucci (d), Henry J. Dargie (e) Abstract: In the CAPRICORN trial, carvedilol reduced all-cause mortality by 23% over a mean follow-up of 1.3 years in clinically stabilized post-myocardial infarction (MI) patients with left ventricular dysfunction (LVD) with or without signs of heart failure. This analysis sought to assess the impact of carvedilol within the first 30 days of randomization. Author Affiliation: (a) Ahmanson-UCLA Cardiomyopathy Center, David Geffen School of Medicine at UCLA, Los Angeles, CA (b) Cardiovascular and Metabolic Medicine Development Center, GlaxoSmithKline, Philadelphia, PA (c) Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom (d) Section of Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA (e) Department of Cardiology, Western Infirmary, Glasgow, United Kingdom Article History: Received 16 April 2007; Accepted 10 June 2007

Published
2007

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