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13 results on '"Robertson, K.J."'

2. Persistent differences among centers over 3 years in glycemic control and hypoglycemia in a study of 3,805 children and adolescents with type 1 diabetes from the Hvidøre Study Group

Author

Danne, T., Mortensen, H.B., Hougaard, P., Lynggaard, H., Aanstoot, H.-J., Chiarelli, F., Daneman, D., Dinesen, B., Dorchy, H., Garandeau, P., Greene, S., Hoey, H., Holl, R.W., Kaprio, E.A., Kocova, M., Martul, P., Matsuura, N., Robertson, K.J., Schoenle, E.J., Søvik, O., Swift, P.G.F., Tsou, R.M., Vanelli, M., and Åman, J.

Published
2001

3. Are family factors universally related to metabolic outcomes in adolescents with Type 1 diabetes?

Author

Cameron, F.J., Skinner, T.C., Beaufort, C.E. de, Hoey, H., Swift, P.G.F., Aanstoot, H., Aman, J., Martul, P., Chiarelli, F., Daneman, D., Danne, T., Dorchy, H., Kaprio, E.A., Kaufman, F., Kocova, M., Njolstad, P.R., Phillip, M., Robertson, K.J., Schoenle, E.J., Urakami, T., Vanelli, M., Ackermann, R.W., Skovlund, S.E., Mortensen, Henrik B., Cameron, F.J., Skinner, T.C., Beaufort, C.E. de, Hoey, H., Swift, P.G.F., Aanstoot, H., Aman, J., Martul, P., Chiarelli, F., Daneman, D., Danne, T., Dorchy, H., Kaprio, E.A., Kaufman, F., Kocova, M., Njolstad, P.R., Phillip, M., Robertson, K.J., Schoenle, E.J., Urakami, T., Vanelli, M., Ackermann, R.W., Skovlund, S.E., and Mortensen, Henrik B.

Abstract

Aims To assess the importance of family factors in determining metabolic outcomes in adolescents with Type 1 diabetes in 19 countries. Methods Adolescents with Type 1 diabetes aged 11-18 years, from 21 paediatric diabetes care centres, in 19 countries, and their parents were invited to participate. Questionnaires were administered recording demographic data, details of insulin regimens, severe hypoglycaemic events and number of episodes of diabetic ketoacidosis. Adolescents completed the parental involvement scale from the Diabetes Quality of Life for Youth-Short Form (DQOLY-SF) and the Diabetes Family Responsibility Questionnaire (DFRQ). Parents completed the DFRQ and a Parental Burden of Diabetes score. Glycated haemoglobin (HbA(1c)) was analysed centrally on capillary blood. Results A total of 2062 adolescents completed a questionnaire, with 2036 providing a blood sample; 1994 parents also completed a questionnaire. Family demographic factors that were associated with metabolic outcomes included: parents living together (t = 4.1; P < 0.001), paternal employment status (F = 7.2; d.f. = 3; P < 0.001), parents perceived to be over-involved in diabetes care (r = 0.11; P < 0.001) and adolescent-parent disagreement on responsibility for diabetes care practices (F = 8.46; d.f. = 2; P < 0.001). Although these factors differed between centres, they did not account for centre differences in metabolic outcomes, but were stronger predictors of metabolic control than age, gender or insulin treatment regimen. Conclusions Family factors, particularly dynamic and communication factors such as parental over-involvement and adolescent-parent concordance on responsibility for diabetes care appear be important determinants of metabolic outcomes in adolescents with diabetes. However, family dynamic factors do not account for the substantial differences in metabolic outcomes between centres Udgivelsesdato: 2008/4

Published
2008

9. Comparisons of P‐glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta

Author

Barrand, M.A., Robertson, K.J., and von Weikersthal, S.F.

Abstract

In vivo expression of P‐glycoprotein in isolated rat brain microvessels is compared with that in vitro in primary cultures of brain endothelial cells. More P‐glycoprotein is detected by Western immunoblotting in microvessels than in cultured endothelium. RT‐PCR with isoform‐specific primers and immunoblotting with a mdr1b‐specific antibody reveals only mdr1a in vivo but both mdr1a and mdr1b in vitro. Thus mdr1a decreases whereas mdr1b increases during culture. P‐Glycoprotein activity is evident in vitro, with resistance modulators, e.g. verapamil, producing increases in intracellular [3H]vincristine accumulation. Endothelial cells cultured from epididymal fat pad microvasculature and aorta contain little or no P‐glycoprotein. Here, resistance modulators are less effective.

Published
1995
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