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1. Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis

Author

Zavaliangos‐Petropulu, Artemis, Lo, Bethany, Donnelly, Miranda R, Schweighofer, Nicolas, Lohse, Keith, Jahanshad, Neda, Barisano, Giuseppe, Banaj, Nerisa, Borich, Michael R, Boyd, Lara A, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Charalambous, Charalambos C, Conforto, Adriana B, DiCarlo, Julie A, Dula, Adrienne N, Egorova‐Brumley, Natalia, Etherton, Mark R, Feng, Wuwei, Fercho, Kelene A, Geranmayeh, Fatemeh, Hanlon, Colleen A, Hayward, Kathryn S, Hordacre, Brenton, Kautz, Steven A, Khlif, Mohamed Salah, Kim, Hosung, Kuceyeski, Amy, Lin, David J, Liu, Jingchun, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Piras, Fabrizio, Ramos‐Murguialday, Ander, Revill, Kate P, Roberts, Pamela S, Robertson, Andrew D, Schambra, Heidi M, Seo, Na Jin, Shiroishi, Mark S, Stinear, Cathy M, Soekadar, Surjo R, Spalletta, Gianfranco, Taga, Myriam, Tang, Wai Kwong, Thielman, Gregory T, Vecchio, Daniela, Ward, Nick S, Westlye, Lars T, Werden, Emilio, Winstein, Carolee, Wittenberg, George F, Wolf, Steven L, Wong, Kristin A, Yu, Chunshui, Brodtmann, Amy, Cramer, Steven C, Thompson, Paul M, and Liew, Sook‐Lei

Subjects
Neurosciences, Stroke, Aging, Brain Disorders, Cross-Sectional Studies, Female, Hippocampus, Humans, Male, Quality of Life, Recovery of Function, Stroke Rehabilitation, Upper Extremity, hippocampus, MRI, sensorimotor impairment, stroke, Cardiorespiratory Medicine and Haematology
Abstract

Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, P

Published
2022

2. A large, curated, open-source stroke neuroimaging dataset to improve lesion segmentation algorithms

Author

Liew, Sook-Lei, Lo, Bethany P, Donnelly, Miranda R, Zavaliangos-Petropulu, Artemis, Jeong, Jessica N, Barisano, Giuseppe, Hutton, Alexandre, Simon, Julia P, Juliano, Julia M, Suri, Anisha, Wang, Zhizhuo, Abdullah, Aisha, Kim, Jun, Ard, Tyler, Banaj, Nerisa, Borich, Michael R, Boyd, Lara A, Brodtmann, Amy, Buetefisch, Cathrin M, Cao, Lei, Cassidy, Jessica M, Ciullo, Valentina, Conforto, Adriana B, Cramer, Steven C, Dacosta-Aguayo, Rosalia, de la Rosa, Ezequiel, Domin, Martin, Dula, Adrienne N, Feng, Wuwei, Franco, Alexandre R, Geranmayeh, Fatemeh, Gramfort, Alexandre, Gregory, Chris M, Hanlon, Colleen A, Hordacre, Brenton G, Kautz, Steven A, Khlif, Mohamed Salah, Kim, Hosung, Kirschke, Jan S, Liu, Jingchun, Lotze, Martin, MacIntosh, Bradley J, Mataró, Maria, Mohamed, Feroze B, Nordvik, Jan E, Park, Gilsoon, Pienta, Amy, Piras, Fabrizio, Redman, Shane M, Revill, Kate P, Reyes, Mauricio, Robertson, Andrew D, Seo, Na Jin, Soekadar, Surjo R, Spalletta, Gianfranco, Sweet, Alison, Telenczuk, Maria, Thielman, Gregory, Westlye, Lars T, Winstein, Carolee J, Wittenberg, George F, Wong, Kristin A, and Yu, Chunshui

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Physical Sciences, Stroke, Neurosciences, Bioengineering, Networking and Information Technology R&D (NITRD), Algorithms, Brain, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Neuroimaging
Abstract

Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification of lesion burden and accurate image processing. Current automated lesion segmentation methods for T1-weighted (T1w) MRIs, commonly used in stroke research, lack accuracy and reliability. Manual segmentation remains the gold standard, but it is time-consuming, subjective, and requires neuroanatomical expertise. We previously released an open-source dataset of stroke T1w MRIs and manually-segmented lesion masks (ATLAS v1.2, N = 304) to encourage the development of better algorithms. However, many methods developed with ATLAS v1.2 report low accuracy, are not publicly accessible or are improperly validated, limiting their utility to the field. Here we present ATLAS v2.0 (N = 1271), a larger dataset of T1w MRIs and manually segmented lesion masks that includes training (n = 655), test (hidden masks, n = 300), and generalizability (hidden MRIs and masks, n = 316) datasets. Algorithm development using this larger sample should lead to more robust solutions; the hidden datasets allow for unbiased performance evaluation via segmentation challenges. We anticipate that ATLAS v2.0 will lead to improved algorithms, facilitating large-scale stroke research.

Published
2022

3. The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain–behavior relationships after stroke

Author

Liew, Sook‐Lei, Zavaliangos‐Petropulu, Artemis, Jahanshad, Neda, Lang, Catherine E, Hayward, Kathryn S, Lohse, Keith R, Juliano, Julia M, Assogna, Francesca, Baugh, Lee A, Bhattacharya, Anup K, Bigjahan, Bavrina, Borich, Michael R, Boyd, Lara A, Brodtmann, Amy, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Conforto, Adriana B, Craddock, R Cameron, Dimyan, Michael A, Dula, Adrienne N, Ermer, Elsa, Etherton, Mark R, Fercho, Kelene A, Gregory, Chris M, Hadidchi, Shahram, Holguin, Jess A, Hwang, Darryl H, Jung, Simon, Kautz, Steven A, Khlif, Mohamed Salah, Khoshab, Nima, Kim, Bokkyu, Kim, Hosung, Kuceyeski, Amy, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Piras, Fabrizio, Ramos‐Murguialday, Ander, Richard, Geneviève, Roberts, Pamela, Robertson, Andrew D, Rondina, Jane M, Rost, Natalia S, Sanossian, Nerses, Schweighofer, Nicolas, Seo, Na Jin, Shiroishi, Mark S, Soekadar, Surjo R, Spalletta, Gianfranco, Stinear, Cathy M, Suri, Anisha, Tang, Wai Kwong W, Thielman, Gregory T, Vecchio, Daniela, Villringer, Arno, Ward, Nick S, Werden, Emilio, Westlye, Lars T, Winstein, Carolee, Wittenberg, George F, Wong, Kristin A, Yu, Chunshui, Cramer, Steven C, and Thompson, Paul M

Subjects
Stroke, Brain Disorders, Biomedical Imaging, Neurosciences, Behavioral and Social Science, Humans, Magnetic Resonance Imaging, Multicenter Studies as Topic, Neuroimaging, Stroke Rehabilitation, big data, lesions, MRI, neuroinformatics, stroke, Cognitive Sciences, Experimental Psychology
Abstract

The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large-scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided.

Published
2022

5. Individual Patient Data Meta-Analysis of Dynamic Cerebral Autoregulation and Functional Outcome After Ischemic Stroke

Author

Beishon, Lucy, Vasilopoulos, Terrie, Salinet, Angela S.M., Levis, Brooke, Barnes, Samuel, Hills, Eleanor, Ramesh, Pranav, Gkargkoula, Panagoula, Minhas, Jatinder S., Castro, Pedro, Brassard, Patrice, Goettel, Nicolai, Gommer, Erik D., Jara, Jose Luis, Liu, Jia, Mueller, Martin, Nasr, Nathalie, Payne, Stephen, Robertson, Andrew D., Simpson, David, Robinson, Thompson G., Panerai, Ronney B., and Nogueira, Ricardo C.

Published
2024
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6. Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Author

Liew, Sook-Lei, Zavaliangos-Petropulu, Artemis, Schweighofer, Nicolas, Jahanshad, Neda, Lang, Catherine E, Lohse, Keith R, Banaj, Nerisa, Barisano, Giuseppe, Baugh, Lee A, Bhattacharya, Anup K, Bigjahan, Bavrina, Borich, Michael R, Boyd, Lara A, Brodtmann, Amy, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Charalambous, Charalambos C, Ciullo, Valentina, Conforto, Adriana B, Craddock, Richard C, Dula, Adrienne N, Egorova, Natalia, Feng, Wuwei, Fercho, Kelene A, Gregory, Chris M, Hanlon, Colleen A, Hayward, Kathryn S, Holguin, Jess A, Hordacre, Brenton, Hwang, Darryl H, Kautz, Steven A, Khlif, Mohamed Salah, Kim, Bokkyu, Kim, Hosung, Kuceyeski, Amy, Lo, Bethany, Liu, Jingchun, Lin, David, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Nordvik, Jan Egil, Petoe, Matthew A, Piras, Fabrizio, Raju, Sharmila, Ramos-Murguialday, Ander, Revill, Kate P, Roberts, Pamela, Robertson, Andrew D, Schambra, Heidi M, Seo, Na Jin, Shiroishi, Mark S, Soekadar, Surjo R, Spalletta, Gianfranco, Stinear, Cathy M, Suri, Anisha, Tang, Wai Kwong, Thielman, Gregory T, Thijs, Vincent N, Vecchio, Daniela, Ward, Nick S, Westlye, Lars T, Winstein, Carolee J, Wittenberg, George F, Wong, Kristin A, Yu, Chunshui, Wolf, Steven L, Cramer, Steven C, Thompson, Paul M, Baugh, Lee, Gallaguet, Adrià Bermudo, Bhattacharya, Anup, Borich, Michael, Boyd, Lara, Brown, Truman, Buetefisch, Cathrin, Byblow, Winston, Cassidy, Jessica, Charalambous, Charalambos, Cloutier, Alison, Cole, James, Conforto, Adriana, Craddock, Richard, Cramer, Steven, Aguayo, Rosalia Dacosta, DiCarlo, Julie, Dimyan, Michael, Domin, Martin, Donnellly, Miranda, Dula, Adrienne, Edwardson, Matthew, and Ermer, Elsa

Subjects
Biological Psychology, Psychology, Rehabilitation, Stroke, Brain Disorders, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, stroke, rehabilitation, sensorimotor behaviour, MRI, subcortical volumes, ENIGMA Stroke Recovery Working Group, Clinical sciences, Biological psychology
Abstract

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P

Published
2021

8. Optical Hemodynamic Imaging of Jugular Venous Dynamics During Altered Central Venous Pressure

Author

Amelard, Robert, Robertson, Andrew D, Patterson, Courtney A, Heigold, Hannah, Saarikoski, Essi, and Hughson, Richard L

Subjects
Physics - Medical Physics
Abstract

An optical imaging system is proposed for quantitatively assessing jugular venous response to altered central venous pressure. The proposed system assesses sub-surface optical absorption changes from jugular venous waveforms with a spatial calibration procedure to normalize incident tissue illumination. Widefield frames of the right lateral neck were captured and calibrated using a novel flexible surface calibration method. A hemodynamic optical model was derived to quantify jugular venous optical attenuation (JVA) signals, and generate a spatial jugular venous pulsatility map. JVA was assessed in three cardiovascular protocols that altered central venous pressure: acute central hypovolemia (lower body negative pressure), venous congestion (head-down tilt), and impaired cardiac filling (Valsalva maneuver). JVA waveforms exhibited biphasic wave properties consistent with jugular venous pulse dynamics when time-aligned with an electrocardiogram. JVA correlated strongly (median, interquartile range) with invasive central venous pressure during graded central hypovolemia (r=0.85, [0.72, 0.95]), graded venous congestion (r=0.94, [0.84, 0.99]), and impaired cardiac filling (r=0.94, [0.85, 0.99]). Reduced JVA during graded acute hypovolemia was strongly correlated with reductions in stroke volume (SV) (r=0.85, [0.76, 0.92]) from baseline (SV: 79$\pm$15 mL, JVA: 0.56$\pm$0.10 a.u.) to -40 mmHg suction (SV: 59$\pm$18 mL, JVA: 0.47$\pm$0.05 a.u.; p$<$0.01). The proposed non-contact optical imaging system demonstrated jugular venous dynamics consistent with invasive central venous monitoring during three protocols that altered central venous pressure. This system provides non-invasive monitoring of pressure-induced jugular venous dynamics in clinically relevant conditions where catheterization is traditionally required, enabling monitoring in non-surgical environments.

Published
2020

12. Characterization of internal jugular vein region-specific distension and flow patterns during progressive volume shifting.

Author

Cohen, Jeremy N., Hedge, Eric T., Greaves, Danielle K., Robertson, Andrew D., Nahas, Hassan, Yu, Alfred C. H, Petersen, Lonnie G., and Au, Jason S.

Subjects
JUGULAR vein, FLUID flow, BLOOD flow, BLOOD volume, THROMBOEMBOLISM
Abstract

Blood volume shifts during postural adjustment lead to irregular distension of the internal jugular vein (IJV). In microgravity, distension may contribute to flow stasis and thromboembolism, though the regional implications and associated risk remain unexplored. We characterized regional differences in IJV volume distension and flow complexity during progressive head-down tilt (HDT) (0°, −6°, −15°, −30°) using conventional ultrasound and vector flow imaging. We also evaluated low-pressure thigh cuffs (40 mmHg) as a fluid shifting countermeasure during −6° HDT. Total IJV volume expanded 139 ± 95% from supine position (4.6 ± 2.7 mL) to −30° HDT (10.3 ± 5.0 mL). Blood flow profiles had greater vector uniformity at the cranial IJV region (P < 0.01) and became more dispersed with increasing tilt (P < 0.01). Qualitatively, flow was more uniform throughout the IJV during its early flow cycle phase and more disorganized during late flow phase. This disorganized flow was accentuated closer to the vessel wall, near the caudal region, and during greater HDT. Low-pressure thigh cuffs during −6° HDT decreased IJV volume at the cranial region (−12 ± 15%; P < 0.01) but not the caudal region (P = 0.20), although flow uniformity was unchanged (both regions, P > 0.25). We describe a distensible IJV accommodating large volume shifts along its length. Prominent flow dispersion was primarily found at the caudal region, suggesting multidirectional blood flow. Thigh cuffs appear effective for decreasing IJV volume but effects on flow complexity are minor. Flow complexity along the vessel length is likely related to IJV distension during chronic volume shifting and may be a precipitating factor for flow stasis and future thromboembolism risk. NEW & NOTEWORTHY: The internal jugular vein (IJV) facilitates cerebral outflow and is sensitive to volume shifts. Concerns about IJV expansion and fluid flow behavior in astronauts have surfaced following thromboembolism reports. Our study explored regional volume distension and blood flow complexity in the IJV during progressive volume shifting. We observed stepwise volume distension and increasing flow dispersion with head-down tilting across all regions. Flow dispersion may pose a risk of future thromboembolism during prolonged volume shifts. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Data-driven biomarkers better associate with stroke motor outcomes than theory-based biomarkers.

Author

Olafson, Emily R, Sperber, Christoph, Jamison, Keith W, Bowren, Mark D, Boes, Aaron D, Andrushko, Justin W, Borich, Michael R, Boyd, Lara A, Cassidy, Jessica M, Conforto, Adriana B, Cramer, Steven C, Dula, Adrienne N, Geranmayeh, Fatemeh, Hordacre, Brenton, Jahanshad, Neda, Kautz, Steven A, Tavenner, Bethany P, MacIntosh, Bradley J, Piras, Fabrizio, and Robertson, Andrew D

Published
2024
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14. ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies

Author

Mutsaerts, Henk J.M.M., Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D., Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O’Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W.A., Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P.A., Wottschel, Viktor, Anazodo, Udunna C., Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P.H., Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J., Achten, Eric, Chappell, Michael A., van Osch, Matthias J.P., Golay, Xavier, Thomas, David L., De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, and Barkhof, Frederik

Published
2020
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15. Assessing the soil carbon sequestration value of a promising energy crop now and into the future

Author

Robertson, Andrew D.

Subjects
631.4, Miscanthus, Carbon sequestration, Energy crops
Abstract

Bioenergy crops have attracted increasing interest over the last two decades as their potential to 1) improve national energy security, 2) substitute finite fuels with renewable alternatives, 3) reduce carbon (C) intensity of energy generation, and 4) remove CO2 from the atmosphere and sequester it in soils. In light of climate change predominantly caused by rising atmospheric greenhouse gas concentrations, the potential importance and value of bioenergy cannot be underestimated. This research used data from a single site in Lincolnshire, UK, in combination with new experimental techniques to examine the C dynamics associated with Miscantus x giganteus. The net C budgets were examined using long term eddy-covariance data alongside measurements of C stocks within the soil and litter layer. Results indicated that using a cradle-to-grave lifecycle analysis, and based on the productivity of this site, Miscanthus as an energy feedstock was marginally better than coal but more C intensive than natural gas. Further, soil C stocks were not seen to change significantly over the first 7 years of cropping. Consequently, a combination of soil fractionation and in combination with natural abundance stable C isotope techniques allowed rates of soil C gain or loss to be estimated over time. Soil C was observed to accumulate at fast rates in stable fractions, those that relate to model pools with turnover times well beyond the lifetime of a Miscanthus plantation – a result not predicted by model simulations performed with the systems models ECOSSE and DayCent. A review of six models parameterised for Miscanthus showed a number of factors that contribute to model uncertainty. The results from this thesis are a crucial first step to helping to define model parameters and improve model performance, and therefore to accurately predict the impacts of Miscanthus on C sequestration in a given location for given environmental conditions.

Published
2015

18. Seated Elliptical Exercise, But Not Periodic Standing, Alleviates Sitting-Induced Changes to Arterial Wave Reflections.

Author

ATHAIDE, CHLOE E., ROBERTSON, ANDREW D., DEVRIES, MICHAELA C., and AU, JASON S.

Subjects
*EXERCISE, *DATA analysis, *STATISTICAL significance, *STANDING position, *HEMODYNAMICS, *DESCRIPTIVE statistics, *CROSSOVER trials, *HEART beat, *SITTING position, *STATISTICS, *PULSE wave analysis, *BLOOD pressure, *DATA analysis software, *VASCULAR diseases, *REGRESSION analysis
Abstract

Purpose: Sedentary behavior may contribute to increased central wave reflection due to associated peripheral vasoconstriction, yet its impact on central hemodynamics and the mitigating effects of interventional strategies have not been thoroughly investigated. We tested whether standing or seated elliptical breaks alleviate the deleterious effects of prolonged sitting on central wave reflections. Methods: Eighteen healthy adults (9 9 females, 25 ± 3 yr) completed three 3-h protocols on separate days: uninterrupted sitting, sitting with periodic standing, and sitting with periodic seated elliptical activity. Central wave reflection, central pulse wave velocity, and lower-limb pulse wave velocity were measured before and after each intervention. Results: Central relative wave reflection magnitude (RM) increased during sitting (0.31 ± 0.05 to 0.35 ± 0.05; P <0.01) but did not change after standing (0.30 ± 0.05 to 0.32 ± 0.04; P = 0.19) or elliptical protocols (0.30 ± 0.05 to 0.30 ± 0.04; P > 0.99). The change in RM during prolonged sitting (ARM) was attenuated with elliptical activity (0.04 ± 0.05 vs 0.00 ± 0.03; P = 0.02) but not with periodic standing (0.04 ± 0.04 vs 0.02 ± 0.05; P = 0.54). In addition, augmentation index and central pulse wave velocity increased after sitting (both P < 0.01) and periodic standing (both P < 0.01) but were unchanged after elliptical activity. Lower limb pulse wave velocity did not change after sitting (P = 0.73) or standing (P = 0.21) but did decrease after elliptical activity (P = 0.03). Conclusions: Prolonged sitting without interruptions increased central wave reflection, whereas elliptical but not standing interruptions were able to ameliorate multiple sitting-induced vascular consequences. More work is required to examine the long-term effectiveness of interruption strategies, as well as the optimal type, frequency, and duration for reducing vascular risk associated with sedentary behaviors. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes

Author

Olafson, Emily R, primary, Sperber, Christoph, additional, Jamison, Keith W, additional, Bowren, Mark D, additional, Boes, Aaron D, additional, Andrushko, Justin W, additional, Borich, Michael R, additional, Boyd, Lara A, additional, Cassidy, Jessica M, additional, Conforto, Adriana B, additional, Cramer, Steven C, additional, Dula, Adrienne N, additional, Geranmayeh, Fatemeh, additional, Hordacre, Brenton, additional, Jahanshad, Neda, additional, Kautz, Steven A, additional, Lo, Bethany, additional, MacIntosh, Bradley J, additional, Piras, Fabrizio, additional, Robertson, Andrew D, additional, Seo, Na Jin, additional, Soekadar, Surjo R, additional, Thomopoulos, Sophia I, additional, Vecchio, Daniela, additional, Weng, Timothy B, additional, Westlye, Lars T, additional, Winstein, Carolee J, additional, Wittenberg, George F, additional, Wong, Kristin A, additional, Thompson, Paul M, additional, Liew, Sook-Lei, additional, and Kuceyeski, Amy F, additional

Published
2023
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26. Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke

Author

Liew, Sook-Lei, primary, Schweighofer, Nicolas, additional, Cole, James H., additional, Zavaliangos-Petropulu, Artemis, additional, Lo, Bethany P., additional, Han, Laura K.M., additional, Hahn, Tim, additional, Schmaal, Lianne, additional, Donnelly, Miranda R., additional, Jeong, Jessica N., additional, Wang, Zhizhuo, additional, Abdullah, Aisha, additional, Kim, Jun H., additional, Hutton, Alexandre, additional, Barisano, Giuseppe, additional, Borich, Michael R., additional, Boyd, Lara A., additional, Brodtmann, Amy, additional, Buetefisch, Cathrin M., additional, Byblow, Winston D., additional, Cassidy, Jessica M., additional, Charalambous, Charalambos C., additional, Ciullo, Valentina, additional, Conforto, Adriana Bastos, additional, Dacosta-Aguayo, Rosalia, additional, DiCarlo, Julie A., additional, Domin, Martin, additional, Dula, Adrienne N., additional, Egorova-Brumley, Natalia, additional, Feng, Wuwei, additional, Geranmayeh, Fatemeh, additional, Gregory, Chris M., additional, Hanlon, Colleen A., additional, Hayward, Kathryn, additional, Holguin, Jess A., additional, Hordacre, Brenton, additional, Jahanshad, Neda, additional, Kautz, Steven A., additional, Khlif, Mohamed Salah, additional, Kim, Hosung, additional, Kuceyeski, Amy, additional, Lin, David J., additional, Liu, Jingchun, additional, Lotze, Martin, additional, MacIntosh, Bradley J., additional, Margetis, John L., additional, Mataro, Maria, additional, Mohamed, Feroze B., additional, Olafson, Emily R., additional, Park, Gilsoon, additional, Piras, Fabrizio, additional, Revill, Kate P., additional, Roberts, Pamela, additional, Robertson, Andrew D., additional, Sanossian, Nerses, additional, Schambra, Heidi M., additional, Seo, Na Jin, additional, Soekadar, Surjo R., additional, Spalletta, Gianfranco, additional, Stinear, Cathy M., additional, Taga, Myriam, additional, Tang, Wai Kwong, additional, Thielman, Greg T., additional, Vecchio, Daniela, additional, Ward, Nick S., additional, Westlye, Lars T., additional, Winstein, Carolee J., additional, Wittenberg, George F., additional, Wolf, Steven L., additional, Wong, Kristin A., additional, Yu, Chunshui, additional, Cramer, Steven C., additional, and Thompson, Paul M., additional

Published
2023
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30. Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis

Author

Zavaliangos-Petropulu, Artemis, Lo, Bethany, Donnelly, Miranda R, Schweighofer, Nicolas, Lohse, Keith, Jahanshad, Neda, Barisano, Giuseppe, Banaj, Nerisa, Borich, Michael R, Boyd, Lara A, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Charalambous, Charalambos C, Conforto, Adriana B, DiCarlo, Julie A, Dula, Adrienne N, Egorova-Brumley, Natalia, Etherton, Mark R, Feng, Wuwei, Fercho, Kelene A, Geranmayeh, Fatemeh, Hanlon, Colleen A, Hayward, Kathryn S, Hordacre, Brenton, Kautz, Steven A, Khlif, Mohamed Salah, Kim, Hosung, Kuceyeski, Amy, Lin, David J, Liu, Jingchun, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Piras, Fabrizio, Ramos-Murguialday, Ander, Revill, Kate P, Roberts, Pamela S, Robertson, Andrew D, Schambra, Heidi M, Seo, Na Jin, Shiroishi, Mark S, Stinear, Cathy M, Soekadar, Surjo R, Spalletta, Gianfranco, Taga, Myriam, Tang, Wai Kwong, Thielman, Gregory T, Vecchio, Daniela, Ward, Nick S, Westlye, Lars T, Werden, Emilio, Winstein, Carolee, Wittenberg, George F, Wolf, Steven L, Wong, Kristin A, Yu, Chunshui, Brodtmann, Amy, Cramer, Steven C, Thompson, Paul M, and Liew, Sook-Lei

Subjects
Male, Aging, hippocampus, sensorimotor impairment, Stroke Rehabilitation, Neurosciences, Recovery of Function, Cardiorespiratory Medicine and Haematology, Hippocampus, stroke, Brain Disorders, Upper Extremity, Stroke, Cross-Sectional Studies, Quality of Life, Humans, Female, MRI
Abstract

Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper-limb sensorimotor impairment. We investigated associations between non-lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results Cross-sectional T1-weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta-Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA-UE (Fugl-Meyer Assessment of Upper Extremity). Robust mixed-effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni-corrected, P

Published
2022

31. The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke.

Author

Liew, Sook-Lei, Liew, Sook-Lei, Zavaliangos-Petropulu, Artemis, Jahanshad, Neda, Lang, Catherine E, Hayward, Kathryn S, Lohse, Keith R, Juliano, Julia M, Assogna, Francesca, Baugh, Lee A, Bhattacharya, Anup K, Bigjahan, Bavrina, Borich, Michael R, Boyd, Lara A, Brodtmann, Amy, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Conforto, Adriana B, Craddock, R Cameron, Dimyan, Michael A, Dula, Adrienne N, Ermer, Elsa, Etherton, Mark R, Fercho, Kelene A, Gregory, Chris M, Hadidchi, Shahram, Holguin, Jess A, Hwang, Darryl H, Jung, Simon, Kautz, Steven A, Khlif, Mohamed Salah, Khoshab, Nima, Kim, Bokkyu, Kim, Hosung, Kuceyeski, Amy, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Piras, Fabrizio, Ramos-Murguialday, Ander, Richard, Geneviève, Roberts, Pamela, Robertson, Andrew D, Rondina, Jane M, Rost, Natalia S, Sanossian, Nerses, Schweighofer, Nicolas, Seo, Na Jin, Shiroishi, Mark S, Soekadar, Surjo R, Spalletta, Gianfranco, Stinear, Cathy M, Suri, Anisha, Tang, Wai Kwong W, Thielman, Gregory T, Vecchio, Daniela, Villringer, Arno, Ward, Nick S, Werden, Emilio, Westlye, Lars T, Winstein, Carolee, Wittenberg, George F, Wong, Kristin A, Yu, Chunshui, Cramer, Steven C, Thompson, Paul M, Liew, Sook-Lei, Liew, Sook-Lei, Zavaliangos-Petropulu, Artemis, Jahanshad, Neda, Lang, Catherine E, Hayward, Kathryn S, Lohse, Keith R, Juliano, Julia M, Assogna, Francesca, Baugh, Lee A, Bhattacharya, Anup K, Bigjahan, Bavrina, Borich, Michael R, Boyd, Lara A, Brodtmann, Amy, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Conforto, Adriana B, Craddock, R Cameron, Dimyan, Michael A, Dula, Adrienne N, Ermer, Elsa, Etherton, Mark R, Fercho, Kelene A, Gregory, Chris M, Hadidchi, Shahram, Holguin, Jess A, Hwang, Darryl H, Jung, Simon, Kautz, Steven A, Khlif, Mohamed Salah, Khoshab, Nima, Kim, Bokkyu, Kim, Hosung, Kuceyeski, Amy, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Piras, Fabrizio, Ramos-Murguialday, Ander, Richard, Geneviève, Roberts, Pamela, Robertson, Andrew D, Rondina, Jane M, Rost, Natalia S, Sanossian, Nerses, Schweighofer, Nicolas, Seo, Na Jin, Shiroishi, Mark S, Soekadar, Surjo R, Spalletta, Gianfranco, Stinear, Cathy M, Suri, Anisha, Tang, Wai Kwong W, Thielman, Gregory T, Vecchio, Daniela, Villringer, Arno, Ward, Nick S, Werden, Emilio, Westlye, Lars T, Winstein, Carolee, Wittenberg, George F, Wong, Kristin A, Yu, Chunshui, Cramer, Steven C, and Thompson, Paul M

Abstract

The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large-scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided.

Published
2022

34. Global brain health modulates the impact of lesion damage on post-stroke sensorimotor outcomes

Author

Liew, Sook-Lei, primary, Schweighofer, Nicolas, additional, Cole, James H., additional, Zavaliangos-Petropulu, Artemis, additional, Lo, Bethany P., additional, Han, Laura K.M., additional, Hahn, Tim, additional, Schmaal, Lianne, additional, Donnelly, Miranda R., additional, Jeong, Jessica N., additional, Wang, Zhizhuo, additional, Abdullah, Aisha, additional, Kim, Jun H., additional, Hutton, Alexandre, additional, Barisano, Giuseppe, additional, Borich, Michael R., additional, Boyd, Lara A., additional, Brodtmann, Amy, additional, Buetefisch, Cathrin M., additional, Byblow, Winston D., additional, Cassidy, Jessica M., additional, Charalambous, Charalambos C., additional, Ciullo, Valentina, additional, Conforto, Adriana B., additional, Dacosta-Aguayo, Rosalia, additional, DiCarlo, Julie A., additional, Domin, Martin, additional, Dula, Adrienne N., additional, Egorova-Brumley, Natalia, additional, Feng, Wuwei, additional, Geranmayeh, Fatemeh, additional, Gregory, Chris M., additional, Hanlon, Colleen A., additional, Holguin, Jess A., additional, Hordacre, Brenton, additional, Jahanshad, Neda, additional, Kautz, Steven A., additional, Khlif, Mohamed Salah, additional, Kim, Hosung, additional, Kuceyeski, Amy, additional, Lin, David J., additional, Liu, Jingchun, additional, Lotze, Martin, additional, MacIntosh, Bradley J., additional, Margetis, John L., additional, Mataro, Maria, additional, Mohamed, Feroze B., additional, Olafson, Emily R., additional, Park, Gilsoon, additional, Piras, Fabrizio, additional, Revill, Kate P., additional, Roberts, Pamela, additional, Robertson, Andrew D., additional, Sanossian, Nerses, additional, Schambra, Heidi M., additional, Seo, Na Jin, additional, Soekadar, Surjo R., additional, Spalletta, Gianfranco, additional, Stinear, Cathy M., additional, Taga, Myriam, additional, Tang, Wai Kwong, additional, Thielman, Greg T., additional, Vecchio, Daniela, additional, Ward, Nick S., additional, Westlye, Lars T., additional, Winstein, Carolee J., additional, Wittenberg, George F., additional, Wolf, Steven L., additional, Wong, Kristin A., additional, Yu, Chunshui, additional, Cramer, Steven C., additional, and Thompson, Paul M., additional

Published
2022
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35. sj-pdf-1-jcb-10.1177_0271678X221119760 - Supplemental material for Transfer function analysis of dynamic cerebral autoregulation: a CARNet white paper 2022 update

Author

Panerai, Ronney B, Brassard, Patrice, Burma, Joel S, Castro, Pedro, Claassen, Jurgen AHR, van Lieshout, Johannes J, Liu, Jia, Lucas, Samuel JE, Minhas, Jatinder S, Mitsis, Georgios D, Nogueira, Ricardo C, Ogoh, Shigehiko, Payne, Stephen J, Rickards, Caroline A, Robertson, Andrew D, Rodrigues, Gabriel D, Smirl, Jonathan D, and Simpson, David M

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221119760 for Transfer function analysis of dynamic cerebral autoregulation: a CARNet white paper 2022 update by Ronney B Panerai, Patrice Brassard, Joel S Burma, Pedro Castro, Jurgen AHR Claassen, Johannes J van Lieshout, Jia Liu, Samuel JE Lucas, Jatinder S Minhas, Georgios D Mitsis, Ricardo C Nogueira, Shigehiko Ogoh, Stephen J Payne, Caroline A Rickards, Andrew D Robertson, Gabriel D Rodrigues, Jonathan D Smirl David M Simpson in Journal of Cerebral Blood Flow & Metabolism

Published
2022
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36. Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Author

Liew, Sook-Lei, Zavaliangos-Petropulu, Artemis, Schweighofer, Nicolas, Jahanshad, Neda, Lang, Catherine E, Lohse, Keith R, Banaj, Nerisa, Barisano, Giuseppe, Baugh, Lee A, Bhattacharya, Anup K, Bigjahan, Bavrina, Borich, Michael R, Boyd, Lara A, Brodtmann, Amy, Buetefisch, Cathrin M, Byblow, Winston D, Cassidy, Jessica M, Charalambous, Charalambos C, Ciullo, Valentina, Conforto, Adriana B, Craddock, Richard C, Dula, Adrienne N, Egorova, Natalia, Feng, Wuwei, Fercho, Kelene A, Gregory, Chris M, Hanlon, Colleen A, Hayward, Kathryn S, Holguin, Jess A, Hordacre, Brenton, Hwang, Darryl H, Kautz, Steven A, Khlif, Mohamed Salah, Kim, Bokkyu, Kim, Hosung, Kuceyeski, Amy, Lo, Bethany, Liu, Jingchun, Lin, David, Lotze, Martin, MacIntosh, Bradley J, Margetis, John L, Mohamed, Feroze B, Nordvik, Jan Egil, Petoe, Matthew A, Piras, Fabrizio, Raju, Sharmila, Ramos-Murguialday, Ander, Revill, Kate P, Roberts, Pamela, Robertson, Andrew D, Schambra, Heidi M, Seo, Na Jin, Shiroishi, Mark S, Soekadar, Surjo R, Spalletta, Gianfranco, Stinear, Cathy M, Suri, Anisha, Tang, Wai Kwong, Thielman, Gregory T, Thijs, Vincent N, Vecchio, Daniela, Ward, Nick S, Westlye, Lars T, Winstein, Carolee J, Wittenberg, George F, Wong, Kristin A, Yu, Chunshui, Wolf, Steven L, Cramer, Steven C, Thompson, Paul M, Baugh, Lee, Gallaguet, Adrià Bermudo, Bhattacharya, Anup, Borich, Michael, Boyd, Lara, Brown, Truman, Buetefisch, Cathrin, Byblow, Winston, Cassidy, Jessica, Charalambous, Charalambos, Cloutier, Alison, Cole, James, Conforto, Adriana, Craddock, Richard, Cramer, Steven, Aguayo, Rosalia Dacosta, DiCarlo, Julie, Dimyan, Michael, Domin, Martin, Donnellly, Miranda, Dula, Adrienne, Edwardson, Matthew, Ermer, Elsa, Etherton, Mark, Fercho, Kelene, Ferris, Jennifer, Geranmayeh, Fatemeh, Gregory, Chris, Hadidchi, Shahram, Hanlon, Colleen, Hayes, Leticia, Hayward, Kathryn, Holguin, Jess, Hwang, Darryl, Jamison, Keith, Juliano, Julia, Kautz, Steven, Lang, Catherine, Lee, Jenny, Lohse, Keith, MacIntosh, Bradley, Margetis, John, Margulies, Daniel, Mataro, Maria, McGregor, Keith, Mohamed, Feroze, Nordvik, Jan, Olafson, Emily, Perera-LLuna, Alexandre, Petoe, Matthew, Phillips, Aaron, Revill, Kate, Robertson, Andrew, Rondina, Jane, Rost, Natalia, Sanossian, Nerses, Schambra, Heidi, Schranz, Christian, Sepehrband, Farshid, Shiroishi, Mark, Simon, Julia, Soekadar, Surjo, Srivastava, Shraddha, Stewart, Jill, Stinear, Cathy, Taga, Myriam, Thielman, Gregory, Thijs, Vincent, Thomopoulos, Sophia, Thompson, Paul, Warach, Steven, Ward, Nick, Werden, Emilio, Westlye, Lars, Wiest, Roland, Winstein, Carolee, Wittenberg, George, Wolf, Steven, Wong, Kristin, Liew, Sook-Lei, Zavaliangos-Petropulu, Artemis, Schweighofer, Nicolas, Jahanshad, Neda, Hordacre, Brenton, and Thompson, Paul M

Subjects
medicine.medical_specialty, Thalamus, Grey matter, Nucleus accumbens, rehabilitation, Physical medicine and rehabilitation, sensorimotor behaviour, Medicine, Mri brain, Stroke survivor, Chronic stroke, Stroke, subcortical volumes, business.industry, AcademicSubjects/SCI01870, Putamen, General Engineering, medicine.disease, stroke, Behavioral data, medicine.anatomical_structure, Ventricle, Post stroke, Original Article, AcademicSubjects/MED00310, business, MRI
Abstract

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P, Liew et al. report the first large-scale examination using high-resolution neuroimaging of subcortical nuclei and sensorimotor behaviour in 828 stroke patients from 28 cohorts worldwide. They discovered novel associations between post-stroke sensorimotor behaviour and specific subcortical nuclei, providing new insight for stroke rehabilitation., Graphical Abstract Graphical Abstract

Published
2022

39. A large, curated, open-source stroke neuroimaging dataset to improve lesion segmentation algorithms

Author

Liew, Sook-Lei, primary, Lo, Bethany, additional, Donnelly, Miranda R., additional, Zavaliangos-Petropulu, Artemis, additional, Jeong, Jessica N., additional, Barisano, Giuseppe, additional, Hutton, Alexandre, additional, Simon, Julia P., additional, Juliano, Julia M., additional, Suri, Anisha, additional, Ard, Tyler, additional, Banaj, Nerisa, additional, Borich, Michael R., additional, Boyd, Lara A., additional, Brodtmann, Amy, additional, Buetefisch, Cathrin M., additional, Cao, Lei, additional, Cassidy, Jessica M., additional, Ciullo, Valentina, additional, Conforto, Adriana B., additional, Cramer, Steven C., additional, Dacosta-Aguayo, Rosalia, additional, Rosa, Ezequiel de la, additional, Domin, Martin, additional, Dula, Adrienne N., additional, Feng, Wuwei, additional, Franco, Alexandre R., additional, Geranmayeh, Fatemeh, additional, Gramfort, Alexandre, additional, Gregory, Chris M., additional, Hanlon, Colleen A., additional, Hordacre, Brenton G., additional, Kautz, Steven A., additional, Khlif, Mohamed Salah, additional, Kim, Hosung, additional, Kirschke, Jan S., additional, Liu, Jingchun, additional, Lotze, Martin, additional, MacIntosh, Bradley J., additional, Mataró, Maria, additional, Mohamed, Feroze B., additional, Nordvik, Jan E., additional, Park, Gilsoon, additional, Pienta, Amy, additional, Piras, Fabrizio, additional, Redman, Shane M., additional, Revill, Kate P., additional, Reyes, Mauricio, additional, Robertson, Andrew D., additional, Seo, Na Jin, additional, Soekadar, Surjo R., additional, Spalletta, Gianfranco, additional, Sweet, Alison, additional, Telenczuk, Maria, additional, Thielman, Gregory, additional, Westlye, Lars T., additional, Winstein, Carolee J., additional, Wittenberg, George F., additional, Wong, Kristin A., additional, and Yu, Chunshui, additional

Published
2021
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41. Orthostatic hypotension and dementia incidence: links and implications

Author

Robertson, Andrew D, Udow, Sean J, Espay, Alberto J, Merola, Aristide, Camicioli, Richard, Lang, Anthony E, and Masellis, Mario

Subjects
orthostatic hypotension, α-synucleinopathies, Review, cognitive impairment, dementia
Abstract

Orthostatic hypotension (OH) is a common condition, particularly in patients with α-synucleinopathies such as Parkinson’s disease, and has a significant impact on activities of daily living and quality of life. Recent data suggest an association with cognitive impairment. Herein, we review the evidence that OH increases the odds of incident mild cognitive impairment and dementia. Potential mechanisms underlying the putative relationship are discussed, including cerebral hypoperfusion, supine hypertension, white matter hyperintensities, and neurodegeneration. Finally, we highlight the challenges with respect to treatment and the negative impact on the quality of life and long-term prognosis presented by the coexistence of OH and dementia. Large population-based studies have reported that OH is associated with about a 20% increased risk of dementia in the general population, while smaller cohort studies suggest an even greater effect in patients with α-synucleinopathies (3- to 7-fold higher than controls). Ultimately, OH exposure is difficult to quantify, predominantly limited to pressure regulation during a one-time orthostatic challenge, and the causative association with dementia may turn out to be bidirectional, especially in α-synucleinopathies. Early diagnosis and treatment of OH may improve long-term prognosis.

Published
2019

46. Comparative effectiveness of less commonly used systemic monotherapies and common combination therapies for moderate to severe psoriasis in the clinical setting

Author

Takeshita, Junko, Wang, Shuwei, Shin, Daniel B., Callis Duffin, Kristina, Krueger, Gerald G., Kalb, Robert E., Weisman, Jamie D., Sperber, Brian R., Stierstorfer, Michael B., Brod, Bruce A., Schleicher, Stephen M., Robertson, Andrew D., Linn, Kristin A., Shinohara, Russell T., Troxel, Andrea B., Van Voorhees, Abby S., and Gelfand, Joel M.

Published
2014
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50. ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies

Author

Researchgr. Neuroradiologie, Beeldverwerking ISI, Brain, Cancer, Researchgr. Systems Radiology, MS Radiologie, Mutsaerts, Henk J M M, Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D, Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O'Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W A, Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P A, Wottschel, Viktor, Anazodo, Udunna C, Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P H, Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J, Achten, Eric, Chappell, Michael A, van Osch, Matthias J P, Golay, Xavier, Thomas, David L, De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, Barkhof, Frederik, Researchgr. Neuroradiologie, Beeldverwerking ISI, Brain, Cancer, Researchgr. Systems Radiology, MS Radiologie, Mutsaerts, Henk J M M, Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D, Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O'Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W A, Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P A, Wottschel, Viktor, Anazodo, Udunna C, Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P H, Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J, Achten, Eric, Chappell, Michael A, van Osch, Matthias J P, Golay, Xavier, Thomas, David L, De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, and Barkhof, Frederik

Published
2020

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