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45 results on '"Roberts, S.C."'

1. Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection

Author

Castaldi, C., Schulz, W., Petrone, M.E., Hahn, A.M., Roberts, S.C., Ferguson, D., Grubaugh, N.D., Breban, M.I., Swanstrom, R.I., Peña-Hernández, M.A., Zhou, S., Yale SARS-CoV-2 Genomic Surveillance Initiative, Hill, V., Chaguza, C., and Pham, K.

Abstract

The chronic infection hypothesis for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant emergence is increasingly gaining credence following the appearance of Omicron. Here, we investigate intrahost evolution and genetic diversity of lineage B.1.517 during a SARS-CoV-2 chronic infection lasting for 471 days (and still ongoing) with consistently recovered infectious virus and high viral genome copies. During the infection, we find an accelerated virus evolutionary rate translating to 35 nucleotide substitutions per year, approximately 2-fold higher than the global SARS-CoV-2 evolutionary rate. This intrahost evolution results in the emergence and persistence of at least three genetically distinct genotypes, suggesting the establishment of spatially structured viral populations continually reseeding different genotypes into the nasopharynx. Finally, we track the temporal dynamics of genetic diversity to identify advantageous mutations and highlight hallmark changes for chronic infection. Our findings demonstrate that untreated chronic infections accelerate SARS-CoV-2 evolution, providing an opportunity for the emergence of genetically divergent variants.

Published
2023
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3. Corrigendum to: More than smell: COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G., Niv, Masha Y., Kelly, Christine E., Bakke, Alyssa J., Cooper, Keiland W., Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y., Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B., Gerkin, Richard C., Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C., Bhutani, Surabhi, Fjaeldstad, Alexander W., Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R., Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A., Lim, Juyun, Whitcroft, Katherine L., Colquitt, Lauren R., Ferdenzi, Camille, Brindha, Evelyn V., Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M., Fiorucci, Sébastien, Philpott, Carl M., Smith, Barry C., Lundström, Johan N., Mucignat, Carla, Parker, Jane K., Van Den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S., Heinbockel, Thomas, Shields, Vonnie D.C., Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E.A., Morini, Gabriella, Olofsson, Jonas K., Jalessi, Maryam, Karni, Noam, D'Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M., Alwashahi, Mohammed K., Welge-Lüssen, Antje, Freiherr, Jessica, De Groot, Jasper H.B., Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W., Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H., Voznessenskaya, Vera V., Chen, Jingguo, Sell, Elizabeth A., Walsh-Messinger, Julie, Archer, Nicholas S., Koyama, Sachiko, Deary, Vincent, Roberts, S.C., Yanlk, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T., Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K., Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M., Restrepo, Diego, Reed, Danielle R., Hummel, Thomas, Munger, Steven D., Hayes, John E., UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, and UCL - (SLuc) Service d'oto-rhino-laryngologie

Subjects
Behavioral Neuroscience, Sensoriek en eetgedrag, Behaviour Change and Well-being, Physiology, Physiology (medical), ddc:540, Life Science, Sensory Systems, Sensory Science and Eating Behaviour, VLAG
Abstract

This is a correction notice for article bjaa041 (DOI: https:// doi.org/10.1093/chemse/bjaa041), published 20 June 2020. An incorrect version of the caption to Figure 5 was mistakenly included in the published paper. An updated version is given below. Neither the data nor the paper's conclusions were affected by this correction. The authors sincerely apologize for the error. (A) Correlations between the 3 principal components with respect to changes in 3 chemosensory modalities (i.e., taste, smell, and chemesthesis). Shades of gray indicate positive correlation, whereas shades of red indicate negative correlations. White denotes no correlation. (B) Clusters of participants identified by k-means clustering. The scatterplot shows each participant's loading on dimension 1 (degree of smell and taste loss, PC1 on x-Axis) and dimension 2 (degree of chemesthesis loss, PC2 on y-Axis). Based on the centroid of each cluster, participants in cluster 1 (blue, N = 1767; top left) are generally characterized by significant smell, taste and chemesthesis loss. Participants in cluster 2 (orange, N = 1724; bottom center) are generally characterized by ratings that reflect smell/taste loss with preserved chemesthesis. Loadings for participants in cluster 3 (green, N = 548; right side) are generally characterized by reduced smell and taste loss, and preserved chemesthesis.

Published
2021

7. Manipulation of Olfactory Signaling and Mate Choice for Conservation Breeding: a Case Study of Harvest Mice

Author

Roberts, S.C. and Gosling, L.M.

Subjects
Muridae -- Protection and preservation, Muridae -- Behavior, Muridae -- Physiological aspects, Scent marking -- Research, Courtship of animals -- Research, Courtship of animals -- Environmental aspects, Courtship of animals -- Physiological aspects, Wildlife conservation -- Research, Wildlife conservation -- Methods, Animal breeding -- Research, Animal breeding -- Methods, Environmental issues, Zoology and wildlife conservation
Abstract

Research on harvest mice (Micromys minutus) shows that females prefer males whose odor was familiar to them, behaving more aggressively towards males with an unfamiliar odor. Transferring male scent marks between collections or cages may therefore prove to be a useful tool in conservation breeding.

Published
2004

9. Emotions in context: Anger causes ethnic bias but not gender bias in men but not women

Author

Kuppens, T., Pollet, T.V., Teixeira, C.P., Demoulin, S., Roberts, S.C., Little, A.C., and Social & Organizational Psychology

Subjects
SDG 5 - Gender Equality, health care economics and organizations, humanities
Abstract

Emotions influence information processing because they are assumed to carry valuable information. We predict that induced anger will increase ethnic but not gender intergroup bias because anger is related to conflicts for resources, and ethnic groups typically compete for resources, whereas gender groups typically engage in relations of positive interdependence. Furthermore, we also predict that this increased ethnic intergroup bias should only be observed among men because men show more group-based reactions to intergroup conflict than women do. Two studies, with 65 and 120 participants, respectively, indeed show that anger induction increases ethnic but not gender intergroup bias and only for men. Intergroup bias was measured with an implicit measure. In Study 2, we additionally predict (and find) that fear induction does not change ethnic or gender intergroup bias because intergroup bias is a psychological preparation for collective action and fear is not associated with taking action against out-groups. We conclude that the effect of anger depends on its specific informational potential in a particular intergroup context. These results highlight that gender groups differ on a crucial point from ethnic groups and call for more attention to the effect of people's gender in intergroup relations research. © 2012 John Wiley & Sons, Ltd.

Published
2012

28. Contributed Papers Manipulation of Olfactory Signaling and Mate Choice for Conservation Breeding: a Case Study of Harvest Mice.

Author

ROBERTS, S.C. and GOSLING, L.M.

Subjects
*ANIMAL courtship, *ANIMAL sexual behavior, *OLFACTORY nerve, *MICE, *ANIMAL breeding, *CONSERVATION biology
Abstract

Mate choice by females can introduce difficulties to captive breeding programs because there may be a conflict between the conservation manager's choice of mate (based on random allocation or maximizing heterogeneity) and the females' own preferences, often resulting in incompatibility and aggression. Similar effects are caused by inappropriate social contexts at the time of pairing. We manipulated the social experience of male and female harvest mice (Micromys minutus ) to investigate whether we could enhance compatibility between randomly allocated mates by altering female preferences. In one experiment, we used a choice test to identify female preferences between two males and then varied the competitive context of unpreferred males by transferring competitor's scent marks into their cages. The manipulation caused them to increase their investment in a form of olfactory signaling (scent marking), which female rodents use as an indicator of male quality when choosing mates. The manipulation increased their attractiveness relative to the initially preferred male when the choice test was repeated. In a second experiment, we tested the effect of females' familiarity with the odor of males by transfer of male scent marks to female cages. Females preferred familiar males in choice tests and were less aggressive toward them when pairs were introduced than females paired with unfamiliar males. This kind of approach can influence mate choice, and transferring scent marks between cages or collections is an effective and practical behavioral means of improving success in conservation breeding programs. [ABSTRACT FROM AUTHOR]

Published
2004
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44. Ethics.

Author

Roberts, S.C.

Subjects
HUMAN Life in the Balance (Book)
Abstract

Reviews the book `Human Life in the Balance,' by David C. Thomasma.

Published
1992

45. Antelopes, Deer, and Relatives (Book Review).

Author

Roberts, S.C.

Subjects
*RUMINANTS, *NONFICTION
Abstract

Reviews the book 'Antelopes, Deer, and Relatives: Fossil Record, Behavioral Ecology, Systematics, and Conservation,' edited by Elisabeth S. Vrba and George B. Schaller.

Published
2001

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