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3. Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways.

Author

Giordano, L, Deceglie, S, d'Adamo, P, Valentino, ML, La Morgia, C, Fracasso, F, Roberti, M, Cappellari, M, Petrosillo, G, Ciaravolo, S, Parente, D, Giordano, C, Maresca, A, Iommarini, L, Del Dotto, V, Ghelli, AM, Salomao, SR, Berezovsky, A, Belfort, R, Sadun, AA, Carelli, V, Loguercio Polosa, P, and Cantatore, P

Subjects
Humans, Optic Atrophy, Hereditary, Leber, Reactive Oxygen Species, DNA, Mitochondrial, Smoking, Oxidative Phosphorylation, Female, Male, Optic Atrophy, Hereditary, Leber, DNA, Mitochondrial, Biochemistry and Cell Biology, Oncology and Carcinogenesis
Abstract

Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disease, is associated with mitochondrial DNA (mtDNA) point mutations affecting Complex I subunits, usually homoplasmic. This blinding disorder is characterized by incomplete penetrance, possibly related to several genetic modifying factors. We recently reported that increased mitochondrial biogenesis in unaffected mutation carriers is a compensatory mechanism, which reduces penetrance. Also, environmental factors such as cigarette smoking have been implicated as disease triggers. To investigate this issue further, we first assessed the relationship between cigarette smoke and mtDNA copy number in blood cells from large cohorts of LHON families, finding that smoking was significantly associated with the lowest mtDNA content in affected individuals. To unwrap the mechanism of tobacco toxicity in LHON, we exposed fibroblasts from affected individuals, unaffected mutation carriers and controls to cigarette smoke condensate (CSC). CSC decreased mtDNA copy number in all cells; moreover, it caused significant reduction of ATP level only in mutated cells including carriers. This implies that the bioenergetic compensation in carriers is hampered by exposure to smoke derivatives. We also observed that in untreated cells the level of carbonylated proteins was highest in affected individuals, whereas the level of several detoxifying enzymes was highest in carriers. Thus, carriers are particularly successful in reactive oxygen species (ROS) scavenging capacity. After CSC exposure, the amount of detoxifying enzymes increased in all cells, but carbonylated proteins increased only in LHON mutant cells, mostly from affected individuals. All considered, it appears that exposure to smoke derivatives has a more deleterious effect in affected individuals, whereas carriers are the most efficient in mitigating ROS rather than recovering bioenergetics. Therefore, the identification of genetic modifiers that modulate LHON penetrance must take into account also the exposure to environmental triggers such as tobacco smoke.

Published
2015

4. PB0508 Direct Oral Anticoagulants for the Treatment of Venous Thromboembolism in Patients with β-Thalassemia: A Multicenter Analysis from the Extension-Myocardial Iron Overload in Thalassemia Network

Author

Raso, S., primary, Meloni, A., additional, Spasiano, A., additional, Salvo, A., additional, Roberti, M., additional, cecinati, V., additional, Ciancio, A., additional, Acquafredda, A., additional, Fotzi, I., additional, Rosso, R., additional, Serra, M., additional, Bosi, C., additional, Napolitano, M., additional, Sucato, V., additional, Giangreco, A., additional, Di Maggio, R., additional, Maggio, A., additional, Vitrano, A., additional, and Cademartiri, F., additional

Published
2023
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5. OC 50.1 Levels of IgG4 Distinguish Immune Tolerance Induction Outcome in Patients with Inherited Hemophilia A: Results from the BrazIT Study

Author

Chaves, D., primary, Ayala, B., additional, Camelo, R., additional, Dias, M., additional, Anegawa, T., additional, de Oliveira, A., additional, Ribeiro, R., additional, Cerqueira, M., additional, Etto, L., additional, Callado, F., additional, Franco, V., additional, Roberti, M., additional, Pinto, I., additional, and Rezende, S., additional

Published
2023
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9. The clinical effectiveness of an integrated multidisciplinary evidence-based program to prevent intraoperative pressure injuries in high-risk children undergoing long-duration surgical procedures: A quality improvement study

Author

Ciprandi, G, Crucianelli, S, Zama, M, Antonielli, G, Armani, R, Aureli, S, Barra, G, Beetham, CJC, Bernardini, G, Cancani, F, Carai, A, Cajozzo, M, Carlesi, L, Cialdella, A, Ciaralli, I, Ciliento, G, Corsetti, T, De Chirico, B, Di Corato, P, Dotta, A, Filippelli, S, Franci, M, Frattaroli, J, Grussu, F, Lico, S, Losani, P, Giergji, M, Magli, S, Marino, SF, Mongelli, A, Nazzarri, M, Pace, M, Palmieri, G, Pannacci, I, Paparozzi, F, Pomponi, M, Portanova, A, Preziosi, A, Ragni, A, Raponi, M, Renzetti, T, Rizzo, M, Roberti, M, Sasso, E, Savarese, I, Secci, S, Selvaggio, D, Serafini, L, Spuntarelli, G, Urbani, U, Vanzi, V, Permatunga, R, Santamaria, N, Ciprandi, G, Crucianelli, S, Zama, M, Antonielli, G, Armani, R, Aureli, S, Barra, G, Beetham, CJC, Bernardini, G, Cancani, F, Carai, A, Cajozzo, M, Carlesi, L, Cialdella, A, Ciaralli, I, Ciliento, G, Corsetti, T, De Chirico, B, Di Corato, P, Dotta, A, Filippelli, S, Franci, M, Frattaroli, J, Grussu, F, Lico, S, Losani, P, Giergji, M, Magli, S, Marino, SF, Mongelli, A, Nazzarri, M, Pace, M, Palmieri, G, Pannacci, I, Paparozzi, F, Pomponi, M, Portanova, A, Preziosi, A, Ragni, A, Raponi, M, Renzetti, T, Rizzo, M, Roberti, M, Sasso, E, Savarese, I, Secci, S, Selvaggio, D, Serafini, L, Spuntarelli, G, Urbani, U, Vanzi, V, Permatunga, R, and Santamaria, N

Abstract

The prevention of hospital-acquired pressure injuries (HAPIs) in children undergoing long-duration surgical procedures is of critical importance due to the potential for catastrophic sequelae of these generally preventable injuries for the child and their family. Long-duration surgical procedures in children have the potential to result in high rates of HAPI due to physiological factors and the difficulty or impossibility of repositioning these patients intraoperatively. We developed and implemented a multi-modal, multi-disciplinary translational HAPI prevention quality improvement program at a large European Paediatric University Teaching Hospital. The intervention comprised the establishment of wound prevention teams, modified HAPI risk assessment tools, specific education, and the use of prophylactic dressings and fluidized positioners during long-duration surgical procedures. As part of the evaluation of the effectiveness of the program in reducing intraoperative HAPI, we conducted a prospective cohort study of 200 children undergoing long-duration surgical procedures and compared their outcomes with a matched historical cohort of 200 children who had undergone similar surgery the previous year. The findings demonstrated a reduction in HAPI in the intervention cohort of 80% (p < 0.01) compared to the comparator group when controlling for age, pathology, comorbidity, and surgical duration. We believe that the findings demonstrate that it is possible to significantly decrease HAPI incidence in these highly vulnerable children by using an evidence-based, multi-modal, multidisciplinary HAPI prevention strategy.

Published
2022

15. Mobilization practices in critically ill children: A European point prevalence study (EU PARK-PICU)

Author

Ista, E. (Erwin), Scholefield, B.R. (Barnaby R.), Manning, J.C. (Joseph C.), Harth, I. (Irene), Gawronski, O. (Orsola), Bartkowska-Śniatkowska, A. (Alicja), Ramelet, A.-S. (Anne-Sylvie), Kudchadkar, S.R. (Sapna R.), Ritson, P.C. (Paul C.), Nikolaou, F. (Filippia), Neef, M. (Marjorie) de, Kneyber, M.C.J. (Martin), Penny-Thomas, K. (Kate), Linton, C. (Christina), Balmaks, R. (Reinis), Richter, M. (Matthias), Chiusolo, F. (Fabrizio), Cecchetti, C. (Corrado), Roberti, M. (Marco), Di Furia, M. (Michela), Grandjean, C. (Chantal), Nygaard, B. (Bettina), Lopez, Y. (Yolanda), Koroglu, T. (Tolga), Besci, T. (Tolga), Mora, R.D.R.D. (Roberta Da Rin Della), Agbeko, R.S. (Rachel S.), Borrows, E. (Emma), Bochaton, N. (Nathalie), Mattsson, J. (Janet), Ksellmann, A. (Anne), Hero, B. (Barbara), Rosada-Kurasińska, J. (Jowita), Świder, M. (Magdalena), Bonaldi, A. (Amabile), Giugni, C. (Cristina), Oruganti, S. (Siva), Gates, S. (Simon), Smith, H. (Hazel), Zwol, A. (Annelies) van, Hills, J. (Jenna), Conroy, J. (Johanna), Bebbington, M. (Mark), Neunhoeffer, F. (Felix), Duval, E.L.I.M. (Els), Ista, E. (Erwin), Scholefield, B.R. (Barnaby R.), Manning, J.C. (Joseph C.), Harth, I. (Irene), Gawronski, O. (Orsola), Bartkowska-Śniatkowska, A. (Alicja), Ramelet, A.-S. (Anne-Sylvie), Kudchadkar, S.R. (Sapna R.), Ritson, P.C. (Paul C.), Nikolaou, F. (Filippia), Neef, M. (Marjorie) de, Kneyber, M.C.J. (Martin), Penny-Thomas, K. (Kate), Linton, C. (Christina), Balmaks, R. (Reinis), Richter, M. (Matthias), Chiusolo, F. (Fabrizio), Cecchetti, C. (Corrado), Roberti, M. (Marco), Di Furia, M. (Michela), Grandjean, C. (Chantal), Nygaard, B. (Bettina), Lopez, Y. (Yolanda), Koroglu, T. (Tolga), Besci, T. (Tolga), Mora, R.D.R.D. (Roberta Da Rin Della), Agbeko, R.S. (Rachel S.), Borrows, E. (Emma), Bochaton, N. (Nathalie), Mattsson, J. (Janet), Ksellmann, A. (Anne), Hero, B. (Barbara), Rosada-Kurasińska, J. (Jowita), Świder, M. (Magdalena), Bonaldi, A. (Amabile), Giugni, C. (Cristina), Oruganti, S. (Siva), Gates, S. (Simon), Smith, H. (Hazel), Zwol, A. (Annelies) van, Hills, J. (Jenna), Conroy, J. (Johanna), Bebbington, M. (Mark), Neunhoeffer, F. (Felix), and Duval, E.L.I.M. (Els)

Abstract

Background: Early mobilization of adults receiving intensive care improves health outcomes, yet little is known about mobilization practices in paediatric intensive care units (PICUs). We aimed to determine the prevalence of and factors associated with physical rehabilitation in PICUs across Europe. Methods: A 2-day, cross-sectional, multicentre point prevalence study was conducted in May and November 2018. The primary outcome was the prevalence of physical therapy (PT)- or occupational therapy (OT)-provided mobility. Clinical data and data on patient mobility, potential mobility safety events, and mobilization barriers were prospectively collected in patients admitted for ≥72 h. Results: Data of 456 children admitted to one of 38 participating PI

Published
2020
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16. High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy

Author

Schneider, Falk, Hernandez-varas, Pablo, Christoffer Lagerholm, B, Shrestha, Dilip, Sezgin, Erdinc, Julia Roberti, M, Ossato, Giulia, Hecht, Frank, Eggeling, Christian, Urbančič, Iztok, Schneider, Falk, Hernandez-varas, Pablo, Christoffer Lagerholm, B, Shrestha, Dilip, Sezgin, Erdinc, Julia Roberti, M, Ossato, Giulia, Hecht, Frank, Eggeling, Christian, and Urbančič, Iztok

Published
2020

27. PB2391 MYOCARDIAL CONTRACTILE FRACTION BY MAGNETIC RESONANCE AND RISK OF CARDIAC COMPLICATIONS IN THALASSEMIA MAJOR

Author

Meloni, A., primary, Pistoia, L., additional, Rosso, R., additional, Bitti, P. P., additional, Caini, M., additional, Carollo, A., additional, Armari, S., additional, Gerardi, C., additional, Roberti, M. G., additional, Fiorenza, M. F., additional, Sarli, R., additional, Renne, S., additional, Positano, V., additional, and Pepe, A., additional

Published
2019
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31. Predictors of responses to immune checkpoint blockade in advanced melanoma

Author

Jacquelot, N, Roberti, M P, Enot, D P, Rusakiewicz, S, Ternès, N, Jegou, S, Woods, D M, Sodré, A L, Hansen, M, Meirow, Y, Sade-Feldman, M, Burra, A, Kwek, S S, Flament, C, Messaoudene, M, Duong, C P M, Chen, L, Kwon, B S, Anderson, A C, Kuchroo, V K, Weide, B, Aubin, F, Borg, C, Dalle, S, Beatrix, O, Ayyoub, M, Balme, B, Tomasic, G, Di Giacomo, A M, Maio, M, et al, and University of Zurich

Subjects
1300 General Biochemistry, Genetics and Molecular Biology, 10177 Dermatology Clinic, 610 Medicine & health, 1600 General Chemistry, 3100 General Physics and Astronomy
Published
2017

36. Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy

Author

Giordano, C., Iommarini, L., Giordano, L., Maresca, A., Pisano, A., Valentino, M. L., Caporali, L., Liguori, R., Deceglie, S., Roberti, M., Fanelli, F., Fracasso, F., Ross Cisneros, F. N., D'Adamo, ADAMO PIO, Hudson, G., Pyle, A., Yu Wai Man, P., Chinnery, P. F., Zeviani, M., Salomao, S. R., Berezovsky, A., Belfort, R., Ventura, D. F., Moraes, M., Moraes Filho, M., Barboni, P., Sadun, F., De Negri, A., Sadun, A. A., Tancredi, A., Mancini, M., D'Amati, G., Loguercio Polosa, P., Cantatore, P., Carelli, V., Univ Rome, Univ Bologna, Univ Bari, Bellaria Hosp, USC, Univ Trieste, Newcastle Univ, Fdn Ist Neurol Carlo Besta IRCCS, MRC Mitochondrial Biol Unit, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Studio Oculist dAzeglio, Osped San Giovanni Evangelista, Azienda Osped San Camillo Forlanini, Giordano C, Iommarini L, Giordano L, Maresca A, Pisano A, Valentino ML, Caporali L, Liguori R, Deceglie S, Roberti M, Fanelli F, Fracasso F, Ross-Cisneros FN, D'Adamo P, Hudson G, Pyle A, Yu-Wai-Man P, Chinnery PF, Zeviani M, Salomao SR, Berezovsky A, Belfort R Jr, Ventura DF, Moraes M, Moraes Filho M, Barboni P, Sadun F, De Negri A, Sadun AA, Tancredi A, Mancini M, d'Amati G, Loguercio Polosa P, Cantatore P, Carelli V, C., Giordano, L., Iommarini, L., Giordano, A., Maresca, A., Pisano, M. L., Valentino, L., Caporali, R., Liguori, S., Deceglie, M., Roberti, F., Fanelli, F., Fracasso, F. N., Ross Cisnero, D'Adamo, ADAMO PIO, G., Hudson, A., Pyle, P., Yu Wai Man, P. F., Chinnery, M., Zeviani, S. R., Salomao, A., Berezovsky, R., Belfort, D. F., Ventura, M., Morae, M., Moraes Filho, P., Barboni, F., Sadun, A., De Negri, A. A., Sadun, A., Tancredi, M., Mancini, G., D'Amati, P., Loguercio Polosa, P., Cantatore, and V., Carelli

Subjects
Adult, Male, mitochondrial biogenesis, Adolescent, mtDNA copy number, Penetrance, and over, Medical and Health Sciences, LHON penetrance, Young Adult, 80 and over, Humans, mitochondrial biogenesi, Aged, Aged, 80 and over, DNA, Mitochondrial, Female, Middle Aged, Mitochondrial Turnover, Optic Atrophy, Hereditary, Leber, Pedigree, lhon, Leber, Neurology & Neurosurgery, Psychology and Cognitive Sciences, lhon penetrance, mtdna copy number, DNA, Mitochondrial, Optic Atrophy, Hereditary
Abstract

Telethon Associazione Serena Talarico per i giovani nel mondo and Fondazione Giuseppe Tomasello O.N.L.U.S. Mitocon Onlus Research to Prevent Blindness International Foundation for Optic Nerve Diseases (IFOND) Struggling Within Leber's Poincenot Family Eierman Foundation National Eye Institute Leber's hereditary optic neuropathy is a maternally inherited blinding disease caused as a result of homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. It is characterized by incomplete penetrance, as only some mutation carriers become affected. Thus, the mitochondrial DNA mutation is necessary but not sufficient to cause optic neuropathy. Environmental triggers and genetic modifying factors have been considered to explain its variable penetrance. We measured the mitochondrial DNA copy number and mitochondrial mass indicators in blood cells from affected and carrier individuals, screening three large pedigrees and 39 independently collected smaller families with Leber's hereditary optic neuropathy, as well as muscle biopsies and cells isolated by laser capturing from post-mortem specimens of retina and optic nerves, the latter being the disease targets. We show that unaffected mutation carriers have a significantly higher mitochondrial DNA copy number and mitochondrial mass compared with their affected relatives and control individuals. Comparative studies of fibroblasts from affected, carriers and controls, under different paradigms of metabolic demand, show that carriers display the highest capacity for activating mitochondrial biogenesis. Therefore we postulate that the increased mitochondrial biogenesis in carriers may overcome some of the pathogenic effect of mitochondrial DNA mutations. Screening of a few selected genetic variants in candidate genes involved in mitochondrial biogenesis failed to reveal any significant association. Our study provides a valuable mechanism to explain variability of penetrance in Leber's hereditary optic neuropathy and clues for high throughput genetic screening to identify the nuclear modifying gene(s), opening an avenue to develop predictive genetic tests on disease risk and therapeutic strategies. Univ Rome, Dept Radiol Oncol & Pathol, Rome, Italy Univ Bologna, Dept Biomed & NeuroMotor Sci DIBINEM, Bologna, Italy Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy Bellaria Hosp, IRCCS Ist Sci Neurol Bologna, I-40139 Bologna, Italy USC, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA USA USC, Keck Sch Med, Dept Neurosurg, Los Angeles, CA USA Univ Trieste, Dept Reprod Sci Dev & Publ Hlth, Trieste, Italy Univ Trieste, IRCCS Burlo Garofolo Children Hosp, Trieste, Italy Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Fdn Ist Neurol Carlo Besta IRCCS, Unit Mol Neurogenet, Milan, Italy MRC Mitochondrial Biol Unit, Cambridge, England Fed Univ São Paulo UNIFESP, Dept Ophthalmol, São Paulo, Brazil Univ São Paulo, Inst Psychol, Dept Expt Psychol, São Paulo, Brazil Studio Oculist dAzeglio, Bologna, Italy Osped San Giovanni Evangelista, Tivoli, Italy Azienda Osped San Camillo Forlanini, Rome, Italy Univ Rome, Dipartimento Metodi & Modelli Econ Finanza & Terr, Rome, Italy Univ Rome, Dept Mol Med, Rome, Italy Fed Univ São Paulo UNIFESP, Dept Ophthalmol, São Paulo, Brazil Telethon: GGP06233 Telethon: GGP11182 Telethon: GPP10005 National Eye Institute: EY03040 Web of Science

Published
2014

37. Quantum dots as ultrasensitive nanoactuators and sensors of amyloid aggregation in live cells

Author

Roberti, M. Julia, Morgan, Marcos, Menendez, Guillermo, Pietrasanta, Lia I., Jovin, Thomas M., and Jares-Erijman, Elizabeth A.

Subjects
Glycoproteins -- Structure, Glycoproteins -- Chemical properties, Glycoproteins -- Optical properties, Quantum electrodynamics -- Analysis, Cysteine -- Chemical properties, Chemistry
Abstract

Quantum dots multifunctionalized with the amyloid protein [alpha]-synuclein which act at nanomolar concentrations as very potent inducers of the aggregation of micromolar-millimolar bulk concentrations of the protein in vitro and in cells are reported. The combination with a tetracysteine-tagged form of [alpha]-synuclein specific for fluorogenic biarsenicals which constitutes a very sensitive system could be applied to study pathological amyloid formation in cells.

Published
2009

38. Predictors of responses to immune checkpoint blockade in advanced melanoma

Author

Jacquelot, N., primary, Roberti, M. P., additional, Enot, D. P., additional, Rusakiewicz, S., additional, Ternès, N., additional, Jegou, S., additional, Woods, D. M., additional, Sodré, A. L., additional, Hansen, M., additional, Meirow, Y., additional, Sade-Feldman, M., additional, Burra, A., additional, Kwek, S. S., additional, Flament, C., additional, Messaoudene, M., additional, Duong, C. P. M., additional, Chen, L., additional, Kwon, B. S., additional, Anderson, A. C., additional, Kuchroo, V. K., additional, Weide, B., additional, Aubin, F., additional, Borg, C., additional, Dalle, S., additional, Beatrix, O., additional, Ayyoub, M., additional, Balme, B., additional, Tomasic, G., additional, Di Giacomo, A. M., additional, Maio, M., additional, Schadendorf, D., additional, Melero, I., additional, Dréno, B., additional, Khammari, A., additional, Dummer, R., additional, Levesque, M., additional, Koguchi, Y., additional, Fong, L., additional, Lotem, M., additional, Baniyash, M., additional, Schmidt, H., additional, Svane, I. M., additional, Kroemer, G., additional, Marabelle, A., additional, Michiels, S., additional, Cavalcanti, A., additional, Smyth, M. J., additional, Weber, J. S., additional, Eggermont, A. M., additional, and Zitvogel, L., additional

Published
2017
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42. Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.

Author

Nanda, VGY, Peng, W, Hwu, P, Davies, MA, Ciliberto, G, Fattore, L, Malpicci, D, Aurisicchio, L, Ascierto, PA, Croce, CM, Mancini, R, Spranger, S, Gajewski, TF, Wang, Y, Ferrone, S, Vanpouille-Box, C, Wennerberg, E, Pilones, KA, Formenti, SC, Demaria, S, Tang, H, Fu, Y-X, Dummer, R, Puzanov, I, Tarhini, A, Chauvin, J-M, Pagliano, O, Fourcade, J, Sun, Z, Wang, H, Sanders, C, Kirkwood, JM, Chen, T-HT, Maurer, M, Korman, AJ, Zarour, HM, Stroncek, DF, Huber, V, Rivoltini, L, Thurin, M, Rau, T, Lugli, A, Pagès, F, Camarero, J, Sancho, A, Jommi, C, de Coaña, YP, Wolodarski, M, Yoshimoto, Y, Gentilcore, G, Poschke, I, Masucci, GV, Hansson, J, Kiessling, R, Scognamiglio, G, Sabbatino, F, Marino, FZ, Anniciello, AM, Cantile, M, Cerrone, M, Scala, S, D’alterio, C, Ianaro, A, Cirin, G, Liguori, G, Bott, G, Chapman, PB, Robert, C, Larkin, J, Haanen, JB, Ribas, A, Hogg, D, Hamid, O, Testori, A, Lorigan, P, Sosman, JA, Flaherty, KT, Yue, H, Coleman, S, Caro, I, Hauschild, A, McArthur, GA, Sznol, M, Callahan, MK, Kluger, H, Postow, MA, Gordan, R, Segal, NH, Rizvi, NA, Lesokhin, A, Atkins, MB, Burke, MM, Ralabate, A, Rivera, A, Kronenberg, SA, Agunwamba, B, Ruisi, M, Horak, C, Jiang, J, Wolchok, J, Liszkay, G, Maio, M, Mandalà, M, Demidov, L, Stoyakovskiy, D, Thomas, L, de la Cruz-Merino, L, Atkinson, V, Dutriaux, C, Garbe, C, Wongchenko, M, Chang, I, Koralek, DO, Rooney, I, Yan, Y, Dréno, B, Sullivan, R, Patel, M, Hodi, S, Amaria, R, Boasberg, P, Wallin, J, He, X, Cha, E, Richie, N, Ballinger, M, Smith, DC, Bauer, TM, Wasser, JS, Luke, JJ, Balmanoukian, AS, Kaufman, DR, Zhao, Y, Maleski, J, Leopold, L, Gangadhar, TC, Long, GV, Michielin, O, VanderWalde, A, Andtbacka, RHI, Cebon, J, Fernandez, E, Malvehy, J, Olszanski, AJ, Gause, C, Chen, L, Chou, J, Stephen Hodi, F, Brady, B, Mortier, L, Hassel, JC, Rutkowski, P, McNeil, C, Kalinka-Warzocha, E, Lebbé, C, Ny, L, Chacon, M, Queirolo, P, Loquai, C, Cheema, P, Berrocal, A, Eizmendi, KM, Bar-Sela, G, Hardy, H, Weber, JS, Grob, J-J, Marquez-Rodas, I, Schmidt, H, Briscoe, K, Baurain, J-F, Wolchok, JD, Pinto, R, De Summa, S, Garrisi, VM, Strippoli, S, Azzariti, A, Guida, G, Guida, M, Tommasi, S, Jacquelot, N, Enot, D, Flament, C, Pitt, JM, Vimond, N, Blattner, C, Yamazaki, T, Roberti, M-P, Vetizou, M, Daillere, R, Poirier-Colame, V, la Semeraro, M, Caignard, A, Slingluff, CL, Sallusto, F, Rusakiewicz, S, Weide, B, Marabelle, A, Kohrt, H, Dalle, S, Cavalcanti, A, Kroemer, G, Di Giacomo, AM, Wong, P, Yuan, J, Umansky, V, Eggermont, A, Zitvogel, L, Anna, P, Marco, T, Stefania, S, Francesco, M, Mariaelena, C, Gabriele, M, Antonio, AP, Franco, S, Roberti, MP, Enot, DP, Semeraro, M, Jégou, S, Flores, C, Kwon, BS, Anderson, AC, Borg, C, Aubin, F, Ayyoub, M, De Presbiteris, AL, Cordaro, FG, Camerlingo, R, Fratangelo, F, Mozzillo, N, Pirozzi, G, Patriarca, EJ, Caputo, E, Motti, ML, Falcon, R, Miceli, R, Capone, M, Madonna, G, Mallardo, D, Carrier, MV, Panza, E, De Cicco, P, Armogida, C, Ercolano, G, Botti, G, Cirino, G, Sandru, A, Blank, M, Balatoni, T, Olasz, J, Farkas, E, Szollar, A, Savolt, A, Godeny, M, Csuka, O, Horvath, S, Eles, K, Shoenfeld, Y, Kasler, M, Costantini, S, Capone, F, Moradi, F, Berglund, P, Leandersson, K, Linnskog, R, Andersson, T, Prasad, CP, Nigro, CL, Lattanzio, L, Proby, C, Syed, N, Occelli, M, Cauchi, C, Merlano, M, Harwood, C, Thompson, A, Crook, T, Bifulco, K, Ingangi, V, Minopoli, M, Ragone, C, Pessi, A, Mannavola, F, D’Oronzo, S, Felici, C, Tucci, M, Doronzo, A, Silvestris, F, Ferretta, A, Guida, S, Maida, I, Cocco, T, Passarelli, A, Quaresmini, D, Franzese, O, Palermo, B, Di Donna, C, Sperduti, I, Foddai, M, Stabile, H, Gismondi, A, Santoni, A, Nisticò, P, Sponghini, AP, Platini, F, Marra, E, Rondonotti, D, Alabiso, O, Fierro, MT, Savoia, P, Stratica, F, Quaglino, P, Di Monta, G, Corrado, C, Di Marzo, M, Ugo, M, Di Cecilia, ML, Nicola, M, Fusciello, C, Marra, A, Guarrasi, R, Baldi, C, Russo, R, Di Giulio, G, Faiola, V, Zeppa, P, Pepe, S, Gambale, E, Carella, C, Di 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AE, Danilova, L, Anders, RA, Netto, GJ, Xu, H, Pritchard, TS, Fan, J, Cheadle, C, Cope, L, Drake, CG, Pardoll, DM, Taube, JM, Topalian, SL, Gnjatic, S, Nataraj, S, Imai, N, Rahman, A, Jungbluth, AA, Pan, L, Venhaus, R, Park, A, Lehmann, FF, Lendvai, N, Cohen, AD, Cho, HJ, Daniel, S, and Hirsh, V

Abstract

MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunosc

Published
2016

44. Effetti del trans-3,4',5-trimetossi-3'-amino-stilbene sul ceppo din Leishmania infantum MON1/IPT1

Author

Tolomeo M, Roberti M, Scapozza L, Recanatini M, Barbusca E, Cannizzo G, VITALE, Francesco, Piazza M, COLOMBA, Claudia, SAPORITO, Laura, PAMPINELLA, Diego, TITONE LANZA DI SCALEA, Lucina, Tolomeo M, Colomba C, Roberti M, Scapozza L, Recanatini M, Barbusca E, Cannizzo G, Saporito L, Pampinella D, Vitale F, Piazza M, and Titone Lanza Di Scalea, L

Subjects
Leishmania infantum, stilbeni, apoptosi
Published
2009

46. A Photochromic Bioconjugate with Photoactivatable Fluorescence for Superresolution Imaging

Author

Cusido, Janet, primary, Ragab, Sherif Shaban, additional, Thapaliya, Ek Raj, additional, Swaminathan, Subramani, additional, Garcia-Amorós, Jaume, additional, Roberti, M. Julia, additional, Araoz, Beatriz, additional, Mazza, Mercedes M. A., additional, Yamazaki, Shiori, additional, Scott, Amy M., additional, Raymo, Françisco M., additional, and Bossi, Mariano L., additional

Published
2016
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48. FROM ”SAPIENZA” TO “SAPIENZA, STATE ARCHIVES IN ROME”. A LOOPING EFFECT BRINGING BACK TO THE ORIGINAL SOURCE COMUNICATION AND CULTURE BY INNOVATIVE AND LOW COST 3D SURVEYING, IMAGING SYSTEMS AND GIS APPLICATIONS

Author

Paolini, P., primary, Forti, G., additional, Catalani, G., additional, Lucchetti, S., additional, Menghini, A., additional, Mirandola, A., additional, Pistacchio, S., additional, Porzia, U., additional, and Roberti, M., additional

Published
2016
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50. Nuovi ligandi per il trasportatore della Dopamina quali potenziali farmaci da utilizzare nella terapia da abuso di cocaina

Author

SIMONI D, ROSSI M, BERTOLASI V, ROBERTI M, PIZZIRANI D, RONDANIN R, BARUCHELLO R, GRISOLIA G, TOLOMEO M, GRIMAUDO, Stefania, MERIGGI S, VARANI K, GESSI S, PA BOREA, MARINO S, CAVALLINI S, BIANCHI C, SINISCALCHI A., INVIDIATA, Francesco, SIMONI D, ROSSI M, BERTOLASI V, ROBERTI M, PIZZIRANI D, RONDANIN R, BARUCHELLO R, GRISOLIA G, INVIDIATA FP, TOLOMEO M, GRIMAUDO S, MERIGGI S, VARANI K, GESSI S, PA BOREA, MARINO S, CAVALLINI S, BIANCHI C, and SINISCALCHI A

Published
2004

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