Author: "Roberta Villa" - Searchworks@Jio Institute Digital Library Search Results

88 results on '"Roberta Villa"'

1. Multidisciplinary follow-up in a patient with Morgagni hernia leads to diagnosis of Marfan syndrome

Author: Ester Capecchi, Roberta Villa, Alessandro Pini, Maria Iascone, Laura Messina, Paola Francesca Ajmone, Fabio Mosca, Silvana Gangi, and Maria Francesca Bedeschi
Subjects: Congenital diaphragmatic hernia, FBN1 mutation, Marfan syndrome, Pediatrics, RJ1-570
Abstract: Abstract Background congenital diaphragmatic hernia (CDH) is a birth defect occurring in isolated or syndromic (chromosomal or monogenic) conditions. The diaphragmatic defect can be the most common one: left-sided posterolateral, named Bochdalek hernia; or it can be an anterior-retrosternal defect, named Morgagni hernia. Marfan syndrome (MFS) is a rare autosomal dominant inherited condition that affects connective tissue, caused by mutations in fibrillin-1 gene on chromosome 15. To date various types of diaphragmatic defects (about 30 types) have been reported in association with MFS, but they are heterogeneous, including CDH and paraesophageal hernia. Case presentation We describe the case of a child incidentally diagnosed with Morgagni hernia through a chest X-ray performed due to recurrent respiratory tract infections. Since the diagnosis of CDH, the patient underwent a clinical multidisciplinary follow-up leading to the diagnosis of MFS in accordance with revised Ghent Criteria: the child had typical clinical features and a novel heterozygous de novo single-base deletion in exon 26 of the FBN1 gene, identified by Whole-Exome Sequencing. MFS diagnosis permitted to look for cardiovascular complications and treat them, though asymptomatic, in order to prevent major cardiovascular life-threatening events. Conclusion Our case shows the importance of a long-term and multidisciplinary follow-up in all children with diagnosis of CDH.
Published: 2024
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2. Matrisome and Immune Pathways Contribute to Extreme Vascular Outcomes in Williams–Beuren Syndrome

Author: Delong Liu, Charles J. Billington, Neelam Raja, Zoe C. Wong, Mark D. Levin, Wulfgang Resch, Camille Alba, Daniel N. Hupalo, Elisa Biamino, Maria Francesca Bedeschi, Maria Cristina Digilio, Gabriella Maria Squeo, Roberta Villa, Pheobe C. R. Parrish, Russell H. Knutsen, Sharon Osgood, Joy A. Freeman, Clifton L. Dalgard, Giuseppe Merla, Barbara R. Pober, Carolyn B. Mervis, Amy E. Roberts, Colleen A. Morris, Lucy R. Osborne, and Beth A. Kozel
Subjects: adaptive/innate immune system, elastin (ELN), extreme phenotype, pathway analysis, supravalvar aortic stenosis, Williams–Beuren syndrome, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background Supravalvar aortic stenosis (SVAS) is a characteristic feature of Williams–Beuren syndrome (WBS). Its severity varies: ~20% of people with Williams–Beuren syndrome have SVAS requiring surgical intervention, whereas ~35% have no appreciable SVAS. The remaining individuals have SVAS of intermediate severity. Little is known about genetic modifiers that contribute to this variability. Methods and Results We performed genome sequencing on 473 individuals with Williams–Beuren syndrome and developed strategies for modifier discovery in this rare disease population. Approaches include extreme phenotyping and nonsynonymous variant prioritization, followed by gene set enrichment and pathway‐level association tests. We next used GTEx v8 and proteomic data sets to verify expression of candidate modifiers in relevant tissues. Finally, we evaluated overlap between the genes/pathways identified here and those ascertained through larger aortic disease/trait genome‐wide association studies. We show that SVAS severity in Williams–Beuren syndrome is associated with increased frequency of common and rarer variants in matrisome and immune pathways. Two implicated matrisome genes (ACAN and LTBP4) were uniquely expressed in the aorta. Many genes in the identified pathways were previously reported in genome‐wide association studies for aneurysm, bicuspid aortic valve, or aortic size. Conclusions Smaller sample sizes in rare disease studies necessitate new approaches to detect modifiers. Our strategies identified variation in matrisome and immune pathways that are associated with SVAS severity. These findings suggest that, like other aortopathies, SVAS may be influenced by the balance of synthesis and degradation of matrisome proteins. Leveraging multiomic data and results from larger aorta‐focused genome‐wide association studies may accelerate modifier discovery for rare aortopathies like SVAS.
Published: 2024
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3. P212: Modifiers of arterial stenosis in Williams syndrome: Using genomics to discover drivers of vessel-specific outcomes

Author: Ashley Golbus, Delong Liu, Mark Levin, Neelam Raja, Elisa Biamino, Maria Bedeschi, Maria Digilio, Gabriella Squeo, Roberta Villa, Joy Lynne Freeman, Sharon Osgood, Giuseppe Merla, Barbara Pober, Carolyn Mervis, Amy Roberts, Colleen Morris, Lucy Osborne, and Beth Kozel
Subjects: Genetics, QH426-470, Medicine
Published: 2024
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4. CHARGE syndrome presenting with persistent hypoglycemia: case report and overview of the main genetic syndromes associated with neonatal hypoglycemia

Author: Alessandra Consales, Beatrice Letizia Crippa, Lorenzo Colombo, Roberta Villa, Francesca Menni, Claudia Giavoli, Fabio Mosca, and Maria Francesca Bedeschi
Subjects: neonatal hypoglycemia, CHARGE syndrome, case report, adrenal insufficiency, hyperinsulinemic hypoglycemia, Pediatrics, RJ1-570
Abstract: Abstract Background CHARGE syndrome (CS) is an autosomal dominant genetic condition whose recognition in the neonatal period is complicated by considerable phenotypic variability. Pediatric patients with genetic disorders have a known high incidence of hypoglycemia, due to many concurring factors. To date, neonatal hypoglycemia is a feature poorly explored in the literature associated with CS. This paper adds to the existing literature on hypoglycemia in CS and provides a brief review of the mechanisms through which CS, as well as the main genetic syndromes associated with neonatal hypoglycemia, may determine it. Case presentation The patient was a term newborn, first-born daughter to non-consanguineous parents. At birth, axial hypotonia with slight hypertonia of the limbs, and dysplastic auricles were noted. The incidental finding of asymptomatic hypoglycemia led to the initiation of glucose infusion on the II day of life, continued for a total of 8 days (maximum infusion rate: 8 mg/kg/min). In-depth endocrinological examinations showed poor cortisol response to the hypoglycemic stimulus, with normal GH values, thyroid function and ACTH. In view of the suspected hypoadrenalism, oral hydrocortisone therapy was initiated. Inappropriately low values of plasmatic and urinary ketones supported the hypothesis of concomitant transient hyperinsulinism, not requiring therapy. A brain MRI was performed, documenting thinning of the optic nerves, non-displayable olfactory bulbs and dysmorphic corpus callosum. An eye examination revealed bilateral chorioretinal coloboma. Temporal bone CT scan showed absence of the semicircular canals. The unexpected findings of coloboma and absence of semicircular canals led to the suspicion of CS, later confirmed by the molecular analysis of CHD7. Conclusions It seems important to consider CS in the differential diagnosis of persistent hypoglycemia in newborns with specific anomalies. At the same time, it is advisable to consider the risk of hypoglycemia in children with CS, as well as other genetic syndromes. Awareness of the many possible causes of hypoglycemia in newborns with genetic conditions may help steer the investigations, allowing for an appropriate and timely treatment.
Published: 2022
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5. Neuroimaging appearance of hypothalamic hamartomas in monozygotic twins with Pallister-Hall syndrome: case report and review of the literature

Author: Alessandra Consales, Giulia Ardemani, Claudia Maria Cinnante, Mariana Rita Catalano, Claudia Giavoli, Roberta Villa, Maria Iascone, Camilla Fontana, Maria Francesca Bedeschi, and Monica Fumagalli
Subjects: Hypothalamic hamartoma, Pallister-Hall syndrome, cerebral ultrasound, brain MRI, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Background Pallister-Hall syndrome (OMIM #146510) is a rare autosomal dominant condition caused by a mutation in the GLI3 gene. The cardinal feature of Pallister-Hall syndrome is the presence of hypothalamic hamartomas, which may manifest with seizures, panhypopituitarism and visual impairment. In Pallister-Hall syndrome, dysplastic histogenetic processes responsible for hypothalamic hamartomas are thought to disrupt early craniofacial development. The clinical presentation of Pallister-Hall syndrome may include: characteristic facies (low-set and posteriorly angulated ears, short nose with flat nasal bridge), cleft palate and uvula, bifid epiglottis and laryngotracheal cleft, limb anomalies (e.g., polysyndactyly, short limbs and nail dysplasia), anal atresia, genitourinary abnormalities and congenital heart defects. Case presentation We report the case of two monochorionic diamniotic twins diagnosed with Pallister-Hall syndrome during the neonatal period, after the identification of a hypothalamic hamartoma on day 1 by cerebral ultrasound scan, later confirmed by brain magnetic resonance imaging. Cerebral ultrasound and magnetic resonance imaging presentations were identical in both twins. Discussion and conclusions We review previously published cases (four reports) of hypothalamic hamartomas identified via cerebral ultrasound and compare reported ultrasonographic features. Main differential diagnoses based on cerebral ultrasound findings are discussed. Full description of typical magnetic resonance imaging appearance is also provided. This is the first case reported in the literature of monochorionic diamniotic twins affected by genetically confirmed Pallister-Hall syndrome with identical hypothalamic hamartomas at cerebral ultrasound and magnetic resonance imaging. Moreover, this paper adds to the existing literature on the sonographic appearance of hypothalamic hamartomas. Considering the consistency in hypothalamic hamartomas’ sonographic appearance, we support the use of cerebral ultrasound as a first-line neuroimaging modality in case of clinical suspicion of Pallister-Hall syndrome. Graphical Abstract
Published: 2022
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6. Prenatal overgrowth and polydramnios: Would you think about Noonan syndrome?

Author: Benedetta Beltrami, Jacopo Cerasani, Alessandra Consales, Roberta Villa, Nicoletta Resta, Daria Carmela Loconte, Simona Boito, Luca Caschera, Laura Bassi, Lorenzo Colombo, Maria Iascone, and Maria Francesca Bedeschi
Subjects: cardiovascular disorders, genetics, neurology, obstetrics and gynecology, pediatrics and adolescent medicine, Medicine, Medicine (General), R5-920
Abstract: Abstract We report on a child with prenatal findings of increased nuchal translucency, polydramnios, ascites, and overgrowth. At birth, she presented length >97° centile, minor facial anomalies, megalencephaly, and Wolff–Parkinson–White syndrome. Whole‐exome sequencing showed a pathogenic variant in the NRAS gene, but no mutations were found in PI3K/AKT/mTOR pathway genes.
Published: 2022
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7. A case series of CHARGE syndrome: identification of key features for a neonatal diagnosis

Author: Maria Francesca Bedeschi, Beatrice Letizia Crippa, Lorenzo Colombo, Martina Buscemi, Cesare Rossi, Roberta Villa, Silvana Gangi, Odoardo Picciolini, Claudia Cinnante, Viola Giulia Carlina Fergnani, Paola Francesca Ajmone, Elisa Scola, Fabio Triulzi, and Fabio Mosca
Subjects: CHARGE syndrome, Early diagnosis, Ear malformations, Pediatrics, RJ1-570
Abstract: Abstract Background An early diagnosis of CHARGE syndrome is challenging, especially for the primary care physicians who often take care of neonates with multiple congenital anomalies. Here we report eight cases of CHARGE syndrome whose diagnosis was made early in life with the intent to identify the most helpful features allowing a prompt clinical diagnosis. Methods Medical records of patients with CHARGE syndrome whose diagnosis was made at the Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico in Milan, Italy were retrospectively reviewed. Results Taken together, these patients reflect the considerable phenotypic variability of the syndrome; in one patient, the diagnosis was made immediately after birth because all the major criteria were met. In six patients, presenting with relatively nonspecific defects, a temporal bone computerized tomography scan was essential to achieve the correct diagnosis. In one patient, the diagnosis was made later than the others were. A careful examination revealed the presence of outer, middle, and inner ear anomalies: these elements, in the absence of any additional major criteria, represented for us an important diagnostic clue. Conclusions This article suggests that an accurate evaluation of the ear should be made every time CHARGE syndrome is considered as a likely diagnosis even when the standard criteria are not fulfilled.
Published: 2020
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8. Responsible Research and Innovation Associated With Risk Communication and Public Engagement on Health Emergency Preparedness at the Local Level

Author: Valentina Possenti, Barbara De Mei, Anna Kurchatova, Manfred Green, Kåre Harald Drager, Roberta Villa, Alberto d'Onofrio, Mitra Saadatian-Elahi, Vanessa Moore, Kjersti Brattekas, Pania Karnaki, Ariel Beresniak, Mircea I. Popa, and Donato Greco
Subjects: responsible research and innovation, public health emergency, risk communication, participatory governance, preparedness, response, Communication. Mass media, P87-96
Abstract: Responsible Research and Innovation (RRI) associated with public health emergency preparedness (PHEP) and response pose major challenges to the scientific community and civil society because a multistakeholder and interdisciplinary methodology is needed to foster public engagement. In 2017, within “Action plan on Science in Society related issues in Epidemics and Total pandemics”, twenty-three initiatives in eleven cities—Athens, Brussels, Bucharest, Dublin, Geneva, Haifa, Lyon, Milan, Oslo, Rome, and Sofia—represented effective opportunities for Mobilization and Mutual Learning on RRI issues in the matter of PHEP with different community-level groups. These experiences show that to effectively address a discourse on RRI-related issues in PHEP it is necessary to engage the local population and stakeholders, which is challenging because of needed competencies and resources. Under coronavirus disease 2019 (COVID-19) pandemic, we are proven that such a diversified multistakeholder engagement on RRI related to PHEP locally needs further elaboration and practical development.
Published: 2022
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9. Promoting engagement with quality communication in social media

Author: Matteo Cinelli, Antonio Peruzzi, Ana Lucía Schmidt, Roberta Villa, Enrico Costa, Walter Quattrociocchi, and Fabiana Zollo
Subjects: Medicine, Science
Abstract: The COVID-19 pandemic made explicit the issues of communicating science in an information ecosystem dominated by social media platforms. One of the fundamental communication challenges of our time is to provide the public with reliable content and contrast misinformation. This paper investigates how social media can become an effective channel to promote engagement and (re)build trust. To measure the social response to quality communication, we conducted an experimental study to test a set of science communication recommendations on Facebook and Twitter. The experiment involved communication practitioners and social media managers from select countries in Europe, applying and testing such recommendations for five months. Here we analyse their feedback in terms of adoption and show that some differences emerge across platforms, topics, and recommendation categories. To evaluate these recommendations’ effect on users, we measure their response to quality content, finding that the median engagement is generally higher, especially on Twitter. The results indicate that quality communication strategies may elicit positive feedback on social media. A data-driven and co-designed approach in developing counter-strategies is thus promising in tackling misinformation.
Published: 2022

10. Co-occurrence of Mayer-Rokitansky-Küster-Hauser syndrome and ovarian cancer: A case report and review of the literature

Author: Roberta Villa, Jacopo Azzollini, Bernard Peissel, and Siranoush Manoukian
Subjects: Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a congenital disorder of yet unknown etiology, characterized by agenesis/hypoplasia of the müllerian duct system. The occurrence of ovarian cancer (OC) in MRKHS is rare, with
Published: 2019
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11. Dottore, ma è vero che...?: Covid-19: le risposte alle domande che ci facciamo ogni giorno

Author: Roberta Villa
Published: 2022

12. Vaccini. Mai così temuti, mai così attesi: Tutto quello che c'è da sapere sui vaccini anti Covid

Author: Roberta Villa
Published: 2021

13. Chung– <scp>Jansen</scp> syndrome can mimic <scp>Cornelia de Lange</scp> syndrome: Another player among chromatinopathies?

Author: Beatrice Conti, Berardo Rinaldi, Martina Rimoldi, Roberta Villa, Maria Iascone, Silvana Gangi, Matteo Porro, Paola Francesca Ajmone, Anna Maria Colli, Fabio Mosca, and Maria Francesca Bedeschi
Subjects: Genetics, Genetics (clinical)
Published: 2023
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14. Pitfalls of whole exome sequencing in undefined clinical conditions with a suspected genetic etiology

Author: Giada Moresco, Ornella Rondinone, Alessia Mauri, Jole Costanza, Carlo Santaniello, Patrizia Colapietro, Emanuele Micaglio, Giovanni Marfia, Chiara Pesenti, Federico Grilli, Berardo Rinaldi, Elisabetta Prada, Giulietta Scuvera, Roberta Villa, Maria Francesca Bedeschi, Monica Rosa Miozzo, Donatella Milani, and Laura Fontana
Subjects: Genetics, Molecular Biology, Biochemistry
Abstract: Whole-Exome Sequencing (WES) is a valuable tool for the molecular diagnosis of patients with a suspected genetic condition. In complex and heterogeneous diseases, the interpretation of WES variants is more challenging given the absence of diagnostic handles and other reported cases with overlapping clinical presentations.To describe candidate variants emerging from trio-WES and possibly associated with the clinical phenotype in clinically heterogeneous conditions.We performed WES in ten patients from eight families, selected because of the lack of a clear clinical diagnosis or suspicion, the presence of multiple clinical signs, and the negative results of traditional genetic tests.Although we identified ten candidate variants, reaching the diagnosis of these cases is challenging, given the complexity and the rarity of these syndromes and because affected genes are already associated with known genetic diseases only partially recapitulating patients' phenotypes. However, the identification of these variants could shed light into the definition of new genotype-phenotype correlations. Here, we describe the clinical and molecular data of these cases with the aim of favoring the match with other similar cases and, hopefully, confirm our diagnostic hypotheses.This study emphasizes the major limitations associated with WES data interpretation, but also highlights its clinical utility in unraveling novel genotype-phenotype correlations in complex and heterogeneous undefined clinical conditions with a suspected genetic etiology.
Published: 2022
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15. Congenital diaphragmatic hernia in Coffin Siris syndrome: Further evidence from two cases

Author: Martina Rimoldi, Berardo Rinaldi, Roberta Villa, Jacopo Cerasani, Benedetta Beltrami, Maria Iascone, Rosamaria Silipigni, Simona Boito, Silvana Gangi, Lorenzo Colombo, Matteo Porro, Claudia Cesaretti, and Maria Francesca Bedeschi
Subjects: Genetics, Genetics (clinical)
Published: 2022
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16. Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment

Author: Giulia Rodari, Roberta Villa, Matteo Porro, Silvana Gangi, Maria Iascone, Francesca Elli, Federico Giacchetti, Eriselda Profka, Valentina Collini, Alberta Dall’Antonia, Maura Arosio, Giovanna Mantovani, Maria Francesca Bedeschi, and Claudia Giavoli
Subjects: Genetics, Genetics (clinical)
Abstract: Protein arginine methyltransferase 7 (PRMT7) pathogenetic variants have been associated with the human disorder of Short Stature, Brachydactyly, Intellectual Developmental Disability and Seizures syndrome (SBIDDS). Only 15 cases have been described in the literature. Here we report two female dizygotic twins with novel compound heterozygous deleterious variants of PRMT7 and describe the associated endocrine manifestations and short-term response to recombinant growth hormone (rGH) treatment. They were born at 36 + 3 weeks from a dichorionic diamniotic twin pregnancy. Twin A was appropriate for gestational age while Twin B was small for gestational age. Whole exome sequencing analyses showed the same novel compound heterozygous genetic defects in the PRMT7 gene (c.1220 G A of maternal origin; c.1323 + 2 T G of paternal origin, Fig. 1). Due to severe short stature and growth impairment, at six years of age, endocrine investigations were performed to rule out growth hormone (GH) deficiency, and revealed GH deficiency (GHD) in Twin A and an appropriate GH response in Twin B. Therefore, both started rGH, albeit at different dosages according to the underlying diagnosis. Both showed a satisfactory short-term response to treatment with height gain (∆HT) of +0.52 SDS (Twin A) and +0.88 SDS (Twin B) during the first year. In conclusion, our findings expand the knowledge about the endocrine manifestations associated with PRMT7 pathogenetic variants, including GH deficiency and rGH response. Further studies are needed to investigate long-term outcomes and establish whether PRMT7 genetic defects can be included among syndromic short stature treatable with rGH.
Published: 2022
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17. Family history is key to the interpretation of exome sequencing in the prenatal context: unexpected diagnosis of Basal Cell Nevus Syndrome

Author: Berardo Rinaldi, Claudia Cesaretti, Simona Boito, Roberta Villa, Silvana Guerneri, Irene Borzani, Tommaso Rizzuti, Daniela Marchetti, Giorgio Conte, Claudia Cinnante, Fabio Triulzi, Nicola Persico, Maria Iascone, and Federica Natacci
Subjects: Fetus, Pregnancy, Prenatal Diagnosis, Exome Sequencing, Humans, Obstetrics and Gynecology, Basal Cell Nevus Syndrome, Exome, Female, Ultrasonography, Prenatal, Genetics (clinical)
Abstract: To reach a molecular diagnosis for a family with two consecutive fetuses presenting with multiple congenital anomalies.The two fetuses underwent prenatal ultrasound, autopsy, radiologic, and genetic investigation. Genetic analysis included karyotype and array-CGH for both fetuses and trio-based whole exome sequencing (WES) only for the second fetus.WES results, initially focusing on recessive or dominant de novo variants, were negative.However, as a result of new relevant information regarding family history, the variant c.648_651dup in the PTCH1 gene was identified as causative of the fetal phenotype.This case further highlights how WES data analysis and interpretation strongly rely on family history and robust genotype-phenotype correlation. This is even more relevant in the prenatal setting, where access to fetal phenotype is limited and prenatal recognition of many morbid genes is not fully explored. We also provide a detailed description of the prenatal manifestations of Basal Cell Nevus Syndrome.
Published: 2022
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18. Il Progetto Teatrando. Un ponte di connessioni

Author: Roberta Villa, Alessia Repossi, Vaninka Riccardi, and Elisabetta Cozzi
Abstract: Il Progetto Teatrando è un'esperienza territoriale di comunità lunga quasi vent'anni, che oggi viene descritta dalle autrici rispondendo agli spunti innovativi del welfare contemporaneo. Un contributo riferito a esperienze sul campo e buone pratiche che vedono, a livello metodologico, il connubio tra teatro sociale e sguardo gestaltico. I protagonisti che partecipano al Progetto Teatrando non sono solo i singoli individui, ma anche gruppi che grazie all'esperienza del teatro sperimentano e si allenano a forme diverse e nuove di cittadinanza attiva. È un esempio di creatività e responsabilità sociale, partecipazione, ideazione, attivazione di sistemi locali di welfare informale. Inoltre la descrizione di questa esperienza in termini evolutivi, ha condotto le autrici a tenere in considerazione i fattori di cambiamento in atto a seguito dell'emergenza sanitaria: come si sono rimodulate le pratiche del teatro nel dover impiegare gli strumenti tecnologici e la relazione a distanza?
Published: 2022
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19. A inserção dos produtores familiares de hortaliças e legumes orgânicos no mercado paulista

Author: Roberta Villa Nova Teixeira da Costa
Published: 2023
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20. Re-sleeve gastrectomy: weight loss, comorbidities and gerd evaluation in a large series with 5 years of follow-up

Author: Marta Bonaldi, Carolina Rubicondo, Riccardo Giorgi, Giovanni Cesana, Francesca Ciccarese, Matteo Uccelli, Adelinda Zanoni, Roberta Villa, Stefano De Carli, Alberto Oldani, Ayman Ismail, Francesco Di Capua, and Stefano Olmi
Subjects: Surgery
Published: 2023
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21. Celiac disease prevalence and predisposing-HLA in a cohort of 93 Williams-Beuren syndrome patients

Author: Cecilia Ghisleni, Barbara Parma, Paola Cianci, Anita De Paoli, Elisabetta Pangallo, Teresa Agovino, Anna Cereda, Maria Francesca Bedeschi, Roberta Villa, Chiara Fossati, Piergiorgio Modena, Carolina Giudici, Carla Morando, Luigi Memo, Roberta Onesimo, Giuseppe Zampino, Silvia Salvatore, Massimo Agosti, and Angelo Selicorni
Subjects: Williams-Beuren syndrome, celiac disease, HLA DQ2, HLA DQ8, transglutaminase antibodies, Genetics, Genetics (clinical)
Abstract: Williams-Beuren syndrome is considered to be at increased risk for celiac disease, as for recent literature data and celiac disease guidelines, despite pathogenic mechanisms are still unclear. Our study analyzed the prevalence of autoimmune disorders, HLA DQ2 and/or DQ8 haplotypes, of transglutaminase antibodies and of diagnosis of celiac disease in a cohort of 93 Williams-Beuren syndrome's patients (mean age 21.26 years). Our study showed an increased prevalence of celiac disease equal to 10.8% (10/93 patients). We did not find a significant different frequency of predisposing HLA in subjects with Williams-Beuren syndrome compared to literature data in the general population (49.5% vs. 42.9%, with p .1), nor a susceptibility to autoimmunity. This suggests that the increased prevalence of celiac disease in Williams-Beuren syndrome cannot be ascribed to HLA haplotype and may be related to other factors that still need to be identified in these patients.
Published: 2023

22. CHARGE syndrome presenting with persistent hypoglycemia: case report and overview of the main genetic syndromes associated with neonatal hypoglycemia

Author: Alessandra, Consales, Beatrice Letizia, Crippa, Lorenzo, Colombo, Roberta, Villa, Francesca, Menni, Claudia, Giavoli, Fabio, Mosca, and Maria Francesca, Bedeschi
Subjects: Settore MED/38 - Pediatria Generale e Specialistica, CHARGE syndrome, Infant, Newborn, Infant, Diseases, General Medicine, Newborn, Infant, Newborn, Diseases, Hypoglycemia, Coloboma, Fetal Diseases, adrenal insufficiency, case report, hyperinsulinemic hypoglycemia, neonatal hypoglycemia, Child, Female, Humans, Adrenal Insufficiency, CHARGE Syndrome
Abstract: Background CHARGE syndrome (CS) is an autosomal dominant genetic condition whose recognition in the neonatal period is complicated by considerable phenotypic variability. Pediatric patients with genetic disorders have a known high incidence of hypoglycemia, due to many concurring factors. To date, neonatal hypoglycemia is a feature poorly explored in the literature associated with CS. This paper adds to the existing literature on hypoglycemia in CS and provides a brief review of the mechanisms through which CS, as well as the main genetic syndromes associated with neonatal hypoglycemia, may determine it. Case presentation The patient was a term newborn, first-born daughter to non-consanguineous parents. At birth, axial hypotonia with slight hypertonia of the limbs, and dysplastic auricles were noted. The incidental finding of asymptomatic hypoglycemia led to the initiation of glucose infusion on the II day of life, continued for a total of 8 days (maximum infusion rate: 8 mg/kg/min). In-depth endocrinological examinations showed poor cortisol response to the hypoglycemic stimulus, with normal GH values, thyroid function and ACTH. In view of the suspected hypoadrenalism, oral hydrocortisone therapy was initiated. Inappropriately low values of plasmatic and urinary ketones supported the hypothesis of concomitant transient hyperinsulinism, not requiring therapy. A brain MRI was performed, documenting thinning of the optic nerves, non-displayable olfactory bulbs and dysmorphic corpus callosum. An eye examination revealed bilateral chorioretinal coloboma. Temporal bone CT scan showed absence of the semicircular canals. The unexpected findings of coloboma and absence of semicircular canals led to the suspicion of CS, later confirmed by the molecular analysis of CHD7. Conclusions It seems important to consider CS in the differential diagnosis of persistent hypoglycemia in newborns with specific anomalies. At the same time, it is advisable to consider the risk of hypoglycemia in children with CS, as well as other genetic syndromes. Awareness of the many possible causes of hypoglycemia in newborns with genetic conditions may help steer the investigations, allowing for an appropriate and timely treatment.
Published: 2022

23. Laparoscopic Ventral Hernia Repair in Bariatric Patients: the Role of Defect Size and Deferred Repair

Author: Roberta Villa, Matteo Uccelli, Giovanni Cesana, Adelinda Angela Giulia Zanoni, Riccardo Giorgi, Stefano Olmi, Stefano Maria De Carli, Ayman Ismail, Alberto Oldani, Francesca Ciccarese, Olmi, S., Uccelli, M., Cesana, G. C., Ciccarese, F., Oldani, A., Giorgi, R., De Carli, S. M., Villa, R., Zanoni, A. A. G., and Ismail, A.
Subjects: Sleeve gastrectomy, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Abdominal Hernia, 030209 endocrinology & metabolism, Asymptomatic, Group B, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Laparoscopic ventral hernia repair, medicine, Humans, Herniorrhaphy, Retrospective Studies, Bariatric surgery, Nutrition and Dietetics, business.industry, Composite mesh, Surgical Mesh, Hernia, Ventral, Obesity, Morbid, Surgery, medicine.anatomical_structure, Concomitant, Laparoscopy, 030211 gastroenterology & hepatology, IPOM, medicine.symptom, business
Abstract: Purpose: To analyze the safety of laparoscopic ventral hernia delayed repair in bariatric patients with a composite mesh. Materials and Methods: This retrospective single-center observational trial analyzed all bariatric/obese patients with concomitant ventral hernia who underwent laparoscopic abdominal hernia repair before bariatric surgery (group A) and laparoscopic delayed repair after weight loss obtained by the bariatric procedure (group B). Results: Group A (30 patients) had a mean BMI of 37.8 ± 5.7kg/m2 (range: 34.0–74.2kg/m2); group B (170 patients) had a mean BMI of 24.6 ± 4.5kg/m2 (range 19.0–29.8kg/m2) (p < 0.05). Mean operative time: group A, 51.7 ± 26.6min (range 30–120); group B 38.9 ± 21.5min (range 25–110) (p < 0.05). Average length of stay: group A, 2.0 ± 2.7days (range 1–5) versus group B, 2.8 ± 1.9days (range 1–4) (p > 0.5). Recurrent hernia group A 1/30 (3.3%) versus recurrent hernia group B 4/170 (2.3%) (p > 0.5). Bulging: group A, 3/30 (10.0%) versus group B, 0/170 (0%) (p = 0.23). Conclusion: The present study demonstrates the safety of performing LDR in patient candidates for bariatric surgery in cases of a large abdominal hernia (W2–W3) with a low risk of incarceration or an asymptomatic abdominal hernia. In the case of a small abdominal hernia (W1) or strongly symptomatic abdominal hernia, repair before bariatric surgery, along with subsequent bariatric surgery and any revision of the abdominal wall surgery with weight loss, is preferable.
Published: 2020
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24. A Preliminary Clinical Evaluation of a Topical Product for Reducing Slight Rosacea Imperfections

Author: Claudio Angelinetta, Antonella Praticò, Annamaria Cimicata, Roberta Villa, Daniele Maggioni, Ferdinando Marco Bianchi, and Silvia Busoli Badiale
Subjects: medicine.medical_specialty, Transepidermal water loss, integumentary system, Erythema, business.industry, Topical Product, Dermatology, medicine.disease, Vessel diameter, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Rosacea, 030220 oncology & carcinogenesis, medicine, medicine.symptom, business, Adverse effect, Telangiectasia, Clinical evaluation
Abstract: Introduction Rosacea is a chronic multifactorial skin disorder mainly affecting facial skin with an estimated prevalence of about 5% worldwide. Its main symptoms, occurring early during pathology development, are skin dehydration, redness, erythema, and telangiectasia. Given the lack of a resolutive cure, therapeutic approaches able to relieve the main symptoms are needed. Purpose The aim of this research article is to evaluate the beneficial effect of a topical product (Serum BK46) on rosacea symptoms. Patients and methods A monocentric single-arm, non-blinded study was performed to assess the clinical effect of Serum BK46 in relieving the main symptoms of rosacea: skin dryness, increased trans epidermal water loss (TEWL), redness, and abnormal vascularization. Twenty patients with mild to moderate rosacea were enrolled in the study and asked to apply the product twice per day for 56 days. Skin moisturization, TEWL, and erythema index were instrumentally assessed at baseline and following 24 h and 14, 28 and 56 days of treatment. Clinical parameters, including redness and telangiectasia imperfection visibility, were evaluated on a 5-point scale by a specialized dermatologist at baseline and after 14, 28, and 56 days of treatment. Finally, the visibility of vessel diameter was evaluated at baseline and after 28 and 56 days of treatment. Results Serum BK46 application restored skin hydration and prevented the loss of water by the skin. Long-term treatment with Serum BK46 significantly reduced skin redness, erythema index, and the visibility of telangiectasia imperfections and superficial vessels. The investigated product's clinical effect was demonstrated by both instrumental and clinical evaluation. Furthermore, Serum BK46 was completely tolerated and no adverse effects were recorded. Conclusion The moisturizing and skin barrier restoring action of Serum BK46 has been clearly proven in patients displaying mild to moderate rosacea; thus, this product is a good candidate for rosacea treatment.
Published: 2020
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25. Evaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin Moisturization, Smoothness, and Wrinkles

Author: Ferdinando Marco, Bianchi, Claudio, Angelinetta, Gaetana, Rizzi, Antonella, Praticò, and Roberta, Villa
Subjects: integumentary system, Original Research
Abstract: OBJECTIVE: We sought to assess the efficacy of a hydrolyzed collagen supplement (Lapi Gelatine, Empoli, Italy) for improving skin moisturization and elasticity as well as the appearance of wrinkles. METHODS: A monocentric, randomized, controlled study was performed; the study included 52 volunteers who were divided into two groups. Twenty-six subjects took the collagen supplement and the other 26 participants received maltodextrin for a period of 56 days. Skin moisturization, skin elasticity, and wrinkle depth were instrumentally evaluated. Clinical parameters, including skin softness, skin firmness, skin smoothness, and the visibility of wrinkles were subjectively evaluated by a dermatologist. Finally, the gastrointestinal tolerability was evaluated during the period of treatment. RESULTS: Improvements in skin moisturization, skin elasticity and wrinkle depth were measured in the participants taking the hydrolyzed collagen after 28 days. In all enrolled participants, the results of the analysis of variance showed a statistically significant effect of the interaction between product and time. The evolution over time of the investigated parameters was significantly different between the participants taking the hydrolyzed collagen and the participants taking the maltodextrin. Furthermore, it was well tolerated and no adverse effects were recorded.
Published: 2022

26. Laparoscopic sleeve gastrectomy with Rossetti fundoplication: long-term (5-year) follow-up

Author: Matteo Uccelli, Giovanni Carlo Cesana, Francesca Ciccarese, Alberto Oldani, Riccardo Giorgi, Stefano Maria De Carli, Roberta Villa, Adelinda Angela Giulia Zanoni, Ayman Ismail, Francesco Di Capua, Marta Bonaldi, Carolina Rubicondo, Davide Moioli, and Stefano Olmi
Subjects: Adult, Fundoplication, Middle Aged, Obesity, Morbid, Barrett Esophagus, Gastrectomy, Weight Loss, Gastroesophageal Reflux, Esophagitis, Humans, Surgery, Laparoscopy, Prospective Studies, Follow-Up Studies
Abstract: Gastroesophageal reflux disease (GERD), including erosive esophagitis, is highly prevalent in the obese population. Barrett's esophagus is the consequence of untreated GERD. Laparoscopic sleeve gastrectomy is one of the most frequently performed bariatric procedures. This study presents results after 5 years of follow-up of combined LSG and Rossetti fundoplication for the treatment of GERD, esophagitis, and Barrett's esophagus in patients with morbid obesity.To evaluate long-term results after sleeve gastrectomy with Rossetti fundoplication.Public university hospital in Italy.Since January 2015, more than 450 patients with obesity underwent sleeve gastrectomy with a Rossetti fundoplication procedure as part of prospective studies underway at our center performed by 4 different expert bariatric surgeons. Currently, 127 patients have a follow-up of 5 years or more.Mean patient age was 42.9 ± 10.3 years, and mean body mass index was 42.4 ± 6.1 kg/mLaparoscopic sleeve gastrectomy with Rossetti fundoplication is well tolerated, feasible, and safe in patients with obesity, providing adequate weight loss results and complete resolution of clinical signs of GERD. We have recorded an improvement in esophagitis lesions present at preoperative gastroscopy and complete resolution of Barrett's esophagus within 5 years of follow-up.
Published: 2022

27. Acqua sporca: Che cosa rischiamo di buttare via con il caso Stamina

Author: Antonino Michienzi, Roberta Villa
Published: 2014

28. Global economic burden of unmet surgical need for appendicitis

Author: Reuter, Anna, Rogge, Lisa, Monahan, Mark, Kachapila, Mwayi, Morton, Dion G, Davies, Justine, Vollmer, Sebastian, A A Essam, Abd Elkhalek Sallam, Abd Elrahman Elshafay, Abd El-Rahman Hegazy Khedr, Abdalla Gamal Saad, Abdalla Gharib, Abdalla Kenibar, Abdallah Salah Elsherbiny, Abdalrahman Adel, Abdelaziz Abdelaal, Abdelaziz Osman Abdelaziz Elhendawy, Abdelfatah Hussein, Abdelkader Belkouchi, Abdelmalek Hrora, Abdelrahman Adelshone, Abdelrahman Alkammash, Abdelrahman Assal, Abdelrahman Geuoshy, Abdelrahman Haroun, Abdelrahman Mohammed, Abdelrahman Sayed, Abdelrahman Soliman, Abdelrhman Essam Elnemr, Abdelrhman Kz Darwish, Abdelrhman Osama Elsebaaye, Abdul Khalique, Abdul Rehman Alvi, Abdul Wahid Anwar, Abdulaziz Altwijri, Abdullah Al-Mallah, Abdullah Almoflihi, Abdullah Altamimi, Abdullah Daqeeq, Abdullah Dwydar, Abdullah Gouda, Abdullah Hashim, Abdulmalik Altaf, Abdulmalik Huwait, Abdulrahman Abdel-Aty, Abdulrahman M Altwigry, Abdulrahman Sheshe, Abdulrasheed A Nasir, AbdulRazzaq Oluwagbemiga Lawal, Abdulshafi Khaled Abdrabou, Abdurrahaman Sheshe, Abdussemiu Abdurrazzaaq, Abebe Bekele Zerihun, Abeer Al-Shammari, Abeer El Gendy, Abeer Esam, Abeer Marey, Abhishek Mittal, Abiboye Yifieyeh, Abid Bin Mahamood, Abidemi Adesuyi, Abouelatta Khairy Aly, Abrar Nawawi, Adam Gyedu, Ade Waterman, Adedapo Osinowo, Adedeji Fatuga, Adel Albiety, Adel B Hassanein, Adel Denewar, Adeleke Adekoya, Ademola Adebanjo, Ademola Adeyeye, Ademola Popoola, Adesina Adedeji, Adesoji O Ademuyiwa, Adesoji Tade, Adewale Adeniyi, Adewale O Adisa, Adham Tarek, Adomas Ladukas, Adrian F Palma, Afifatun Hasanah, Afizah Salleh, Afnan Abdelfatah, Afnan Altamimi, Afnan Altamini, Agazi Fitsum, Agboola Taiwo, Ahamed Hassan, Ahed Ghaben, Ahmad Abdel Fattah, Ahmad Abdel Razaq Al Rafati, Ahmad Aboelkassem Ibrahem, Ahmad Aldalaq, Ahmad Ali, Ahmad Almallah, Ahmad Alrifaie, Ahmad Ashour, Ahmad Bakr, Ahmad Bani-Sadar, Ahmad Bin Adnan, Ahmad Elbatahgy, Ahmad Faraz, Ahmad Gudal, Ahmad Hasan, Ahmad Khaled Sabe, Ahmad Khoja, Ahmad Nashaat, Ahmad Qaissieh, Ahmad Sabe, Ahmad Saber Sleem, Ahmad Sakr, Ahmad Shalabi, Ahmad Uzair Qureshi, Ahmed Aamer, Ahmed Abd El Galeel, Ahmed Abd Elmoen Elhusseiny, Ahmed Abd Elsameea, Ahmed Abdelkareem, Ahmed Abdelmotaleb Ghazy, Ahmed Abo El Magd, Ahmed Abo Elazayem, Ahmed Adamu, Ahmed Adel, Ahmed Afandy, Ahmed Ahmed, Ahmed Alghamdi, Ahmed Ali, Ahmed Al-Khatib, Ahmed Altibi, Ahmed Alzahrani, Ahmed Ata, Ahmed Badr, Ahmed Dahy, Ahmed Diab, Ahmed El Kashash, Ahmed El Kholy, Ahmed Elgaili Khalid Musa, Ahmed Elgebaly, Ahmed Elkelany, Ahmed Elkholy, Ahmed El-Sehily, Ahmed Essam, Ahmed Fahiem, Ahmed Farag, Ahmed Fawzy, Ahmed Fouad, Ahmed Gad, Ahmed Ghanem, Ahmed Gheith, Ahmed Gomaa, Ahmed Hafez El-Badri Kotb, Ahmed Hammad, Ahmed Hassan, Ahmed Hossam Eldin Fouad Rida, Ahmed Ismail, Ahmed Karim, Ahmed Khyrallh, Ahmed Lasheen, Ahmed M Rashed, Ahmed Magdy, Ahmed Mahmoud Abdelraouf, Ahmed Menshawy, Ahmed Meshref, Ahmed Mohamed Afifi, Ahmed Mohamed Ibrahim, Ahmed Mohameden, Ahmed Mohammed, Ahmed Mokhtar, Ahmed Mosad, Ahmed Moustafa, Ahmed Moustafa Saeed, Ahmed Negida, Ahmed Rabeih Mohammed, Ahmed Rabie Mohamed, Ahmed Ragab Nayel, Ahmed Ragab Soliman, Ahmed Raslan, Ahmed Raza, Ahmed Refaat, Ahmed Rslan, Ahmed Sabry, Ahmed Sabry El-Hamouly, Ahmed Safwan Marey, Ahmed Saidbadr, Ahmed Sakr, Ahmed Samir, Ahmed Shahine, Ahmed Sheta, Ahmed Soliman, Ahmed Tammam, Ahmed Tarek Abdelbaset Hassan, Ahmed W Shamsedine, Ahmed Zaki, Ahmed Zaki Eldeeb, Ahmed Zohair, Ahmedali M Kandil, Ahmedglal Elnagar, Ahsan Zil-E-Ali, Aijaz Jabbar, Ailsa Claire Snaith, Ainhoa Costas-Chavarri, Aiste Austraite, Ajayesh Mistry, Akin Olaolorun, Akinlabi E Ajao, Al Faifi Jubran, Ala Shamasneh, Alaa Abouelnasr, Alaa Al-Buhaisi, Alaa Bowabsak, Alaa El Jamassi, Alaa Elazab, Alaa Elhadad, Alaa Fergany, Alaa Habeebullah, Alaa Hassan, Alaa Shabkah, Alaa Shaheen, Alaba Adesina, Alan Baird, Alan Grant, Alasdair Ball, Alban Cacurri, Albert Mohale Mphatsoe, Alberto Realis Luc, Alejandro Matheu, Alejandro Munera, Alemayehu Ginbo Bedada, Alessandro Favero, Alessio Maniscalco, Alexander Canta Calua, Alexander J Fowler, Alexandra Gerosa, Alexandre Horobjowsky, Alexandre Venancio De Sousa, Alexia Farrugia, Alexis Pierre Arnaud, Alfio Alessandro Russo, Alfredo Gulielmi, Ali Ababneh, Ali Abo El Dahab, Ali Amin Ahmed Ata, Ali Khan Niazi, Ali Kiasat, Ali Mohamed Hammad, Ali Zardab, Ali Zeynel Abidin Balkan, Aliaa Gamal Toeema, Aliaa Sadek, Aliaksandr Filatau, Aliang Latif, Alibeth Andres Baquero Suarez, Alice Faure, Alice Niragire, Alina Robledo-Rabanal, Aline Broch, Alireza Hasheminia, Alisdair Macdonald, Aliyu Ndajiwo, Allan Novak, Alphonse Zeta Mutabazi, Alvaro Enrique Mendoza Beleño, Alvin Ee Zhiun Cheah, Aly Abd Elrazek, Aly Nasr, Aly Sanad, Alyaa Halim Elgendy, Alyne Daltri Lazzarini Cury, Amal Ibrahim, Amandine Martin, Amani Althwainy, Amany Abouzahra, Amany Eldosouky Mohammed, Amar Kourdouli, Amel Hashish, Amerdip Birring, Amgad Al Meligy, Amina Abdelhamid, Aminah Hanum Haji 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Strazdas, Andy Arenas, Aneel Bhangu, Anele Rudzenskaite, Angel David Pérez Rojas, Angela Dell, Angelica Genoveva Vergara Mejia, Angeline Charles, Angelo Antoniozzi, Angelo Benevento, Angelos Tselos, Angham Solaiman El-Ma'doul, Anjana Sreedharan, Ankur Bhatnagar, Ann Kjellin, Anna Lasek, Anna Maffioli, Anna Powell, Anna Rinaldi, Anna Watts, Annalisa Lo Conte, Annamaria Bigaran, Annelisse Ashton, Annisa Dewi Fitriana Mukin, Antanas Gulbinas, Antanas Zadoroznas, Anthonius Santoso Rulie, Anthony Ajiboye, Anthony Avoka, Anthony Chuk-Him Lai, Anthony Davor, Anthony Sander, Antje Oosterkamp, Antoinette Bediako-Bowan, Antonella La Brocca, Antônio Leal, Antonio Nocito, Antonio Ramos-De La Medina, Antonio Taddei, Anwar Atiyeh, Anyomih Theophilus Teddy Kojo, Aoife Driscoll, Apar Shah, Apostolos Vlachogiorgos, April Camilla Roslani, Aram Abdelhaq, Arazzelly Del Pilar Paucar, Arcangelo Picciariello, Areej Tarek, Arezo Kanani, Ari Leppäniemi, Arianna Birindelli, Arij Ibrahim, Arjun Nesaratnam, Arlindawati Suyadi, Armando José Román Velásquez, Arnaud Bonnard, Arnav Agarwal, Aroub Alkaaki, Arturas Vaicius, Arvin Khamajeet, Arvo Reinsoo, Arwa Abouzaid, Arwa Elfarargy, Arwa Ibrahim, Arwa Mohamed, Asaf Kedar, Asdaq Ahmed, Ased Ali, Aseel Alnusairat, Aseel Hamarshi, Aseel Musleh, Ash Prabhudesai, Ashraf A Maghrabi, Ashraf Morsi, Ashrarur Rahman Mitul, Asmaa Abdelgelil, Asmaa Abdel-Rahman Al-Aarag, Asmaa Rezq, Asmaa Salah, Aspasia Papailia, Assmaa Badwy, Astrid Leusink, Ata Khan, Ataa Ahmed, Athanasia Bamicha, Athar Eysa, Athirah Zulkifli, Atif Mahdi, Attia Attia, Attia Mohamed Attia, Audrey Clarissa, Audrius Dulskas, Audrius Parseliunas, Augusto Zani, Aung Kyaw Tun, Aurel Mironescu, Aurel Sandu Mironescu, Aurelien Scalabre, Aurora Mariani, Aurore Haffreingue, Aurore Thollot, Ausrine Usaityte, Austė Skardžiukaitė, Awais Raza, Aya Abdel Fatah Ibraheem, Aya Aboarab, Aya Adel Elsharkawy, Aya El-Sawy, Aya Elwaey, Aya Firwana, Aya Hagar, Aya Hammad, Aya Mohamed Fathy, Aya Reda, Aya Yehia Ata, Ayah Hamdan, Ayat Hassaan, Ayman And Taher, Ayman Elwan, Ayman Nabawi, Ayman Salman, Ayman Shwky, Ayokunle Ogunyemi, Azher Herebat, Azmina Verjee, Babajide Adenekan, Babatunde Odeyemi, Badr Eldin Adel, Badreldin Adel Tawfik, Bahar Busra Ozkan, Bakeer Mohamed, Bakhtiar Nighat, Bandar Albeladi, Bárbara Málaga, Barbara Mijuskovic, Barbara Pereira Silvestre, Basant Kumar, Basem Sieda, Bashir Bello, Basim Alghamdi, Basma Magdy, Basma Mahmoud, Basmah Alhassan, Bassant Mowafy, Beatrice Brunoni, Beatrix Weber, Belen Sanchez, Ben Thompson, Benoît Parmentier, Bernard Limoges, Bernard Van Duren, Bernhard Wolf, Bertrand Dousset, Besmir Grizhja, Bettina Lieske, Betty Maillot, Billal Mansour, Bjorn Frisk, Bogdan Diaconescu, Bogdan-Valeriu Martian, Boris Marinkovic, Brendan Skelly, Brian Cameron, Britta Dedekind, Bruno Noukpozounkou, Bryon Frankie Hon Khi Chong, Bylapudi Seshu Kumar, Caio Vinícius Barroso de Lima, Calogero Iacono, Cameron Fairfield, Camila Sanchez Samaniego, Camilla Cona, 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Jaradat, Danelo Du Plessis, Daniel Ardian Soeselo, Daniel Cox, Daniel Dabessa, Daniel Estuardo Marroquín Rodríguez, Daniel Hamill, Daniel Nel, Daniel Youssef, Daniela Magri, Daniele Angelieri, Daniele Gui, Danilo Herrera Cruz, Danjuma Sale, Dansou Gaspard Gbessi, Dario Andreotti, Darius Kazanavicius, Darragh McCullagh, David Mcnish, David Merlini, David Monterroso Cohen, Davide De Boni, Davide Rossi, Dayang Nita Abdul Aziz, D C Grobler, Debora Schivo, Deborah Chiesa, Deimante Mikuckyte, Deividas Dragatas, Demi Gray, Diaa Eldin Abdelazeem Amin Elsorogy, Diaa Moustafa Elbendary Elsawahly, Diaaaldin Zahran, Diana Duarte Cadogan, Diana Sanchez, Dickson Bandoh, Diego Alonso Romani Pozo, Diego Antezana, Diego Coletta, Diego Romani, Diego Sasia, Dietmar Öfner, Dieudonne Duhoranenayo, Dimitri Aristotle Raptis, Dimitrios Balalis, Dimitrios K Manatakis, Dimitrios Karousos, Dimitrios Korkolis, Dimitrios Kyziridis, Dimitrios Lytras, Dimitrios Papageorgiou, Dimitrios Sfougaris, Dimitris-Christos Zachariades, Dina Al-Marakby, Dina Faizatur Rahmah, Dina Gamal, Dina Tarek, Dineshwary Periasammy, Diogo Vinicius Dos Santos, Dion Morton, Diya Mirghani, Djifid Morel Seto, D M Cocker, Dmitri A Raptis, Dmitri Nepogodiev, Dmitri Raptis, Doaa Emadeldin, Doaa Gamil, Doaa Hasan, Doaa Hasanain, Doaa Maher Abdelrouf, Domenica Pata, Domingos Mapasse, Dominic Charles Marshall, Donal B O'Connor, Donatas Danys, Donatas Venskutonis, Dorota Radkowiak, Doug Bowley, Dovilè Majauskyté, Dulan Irusha Samaraweera, Durvesh Lacthman Jethwani, Dush Iyer, Dushyant Iyer, Dzianis Khokha, Dzmitry Paulouski, Ebenezer Takyi Atkins, Echaieb Anis, Edgar Domini, Edilberto Temoche, Eduardo Huaman, Edvard Grisin, Edvinas Dainius, Efeson Thomas, Egle Preckailaite, Ehab Alnawam, Ehab Mamdouh, Eirik Kjus Aahlin, Eirini Kefalidi, Ekow Mensah, Elaine Borg, Eldaa Prisca Refianti Sutanto, Eleanor Marks, Elena Goldin, Elena Muzio, Elena Vendramin, Elena Zdanyte Sruogiene, Eleonora Ciccioli, Elio Jovine, Elisa Francone, Elisabeth Jensen, Elissa Rifhan Mohd Basir, Elizabeth Snyder, Ella Teasdale, Elliot Akoto, Elodie Gaignard, Elodie Haraux, Elsa Robert, Elsayed Ali, Elsayed Gamaly, Emad Abdallah, Emad Al-Dakka, Emad Ali Ahmed, Emad Aljohani, Emad Mohamed Saeed Taha, Eman Abd Al Raouf, Eman Abdelmageed, Eman Abuqwaider, Eman Adel Sayma, Eman Elwy, Eman Emara, Eman Hashad, Eman Ibrahim, Eman Magdy, Eman Magdy Hegazy, Eman Mahmoud Abdulhakeem, Eman Mohamed Ibrahim, Eman Mohamed Morshedy, Eman Nofal, Eman Rashad, Eman Yahya Mansor, Emanuel Barrios, Emanuele Rausa, Emeka Nwabuoku, Emilia De Luca, Emilie Eyssartier, Emilio Dijan, Emma Blower, Emma Jurdell, Emma Upchurch, Emmanuel Acquah, Emmanuel Akatibo, Emmanuel Barrios, Emmy Runigamugabo, Enas Alaloul, Enas Alqahtani, Enoch Dagoe, Enoch Tackie, Eriberto Farinella, Eric Ackom, Eric Kofi Appiah, Erick Samuel Florez Farfan, Erik Hervieux, Erik Schadde, Erika Vicario, Erikas Laugzemys, Ernest Yemalin Stephane Ahounou, Eslam Elbanby, Eslam Ezzat, Esraa Abd 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Ferdy Iskandar, Fernanda Altoe, Fernanda Frade, Fernande Djivoh, Fernando Espinoza, Fernando Fernandez-Bueno, Fernando Tale, Ferry Fitriya Ayu Andika, Fidelis Jacklyn Adella, Filippo Di Franco, Finaritra Casimir Fleur Prudence Rahantasoa, Fitjerald Henry, Fitriana Nur Rahmawati, Florence Dedey, Florian Primavesi, Florin-Mihail Iordache, Fong Yee Lam, Foteini Koumpa, Francesca Steccanella, Francesco Pata, Francesco Riente, Francesco Ruben Giardino, Francesco Selvaggi, Francis Abantanga, Francis Dossou, Francisco Fujii, Francisco Regalado, Francois-Coridon Helene, Françoise Schmitt, Frank Enoch Gyamfi, Frank Owusu, Fred Alexander Naranjo Aristizã Bal, Fred Hodonou, Frederick Du Toit, Frederique Sauvat, Fredrik Wogensen, Frehun Ayele Asele, Fridiz Saravia, Gabriel Pardo, Gabriela Elisa Nita, Gaetano Gallo, Gaetano Luglio, Gaetano Tessera, Galaleldin Abdelazim, Gamal Shimy, Gandau Naa Barnabas, Garba Samson, Gareth Irwin, Gehad El Ashal, Gehad Samir El Sayed, Gehad Tawfik, Gemma Humm, Genoveffa Balducci, George Christian Manrique Sila, George Ihediwa, George Manrique Sila, Georges Azzie, Georgette Marie Camilleri, Georgios Gemenetzis, Georgios Gkiokas, Georgios Karabelias, Georgios Kyrou, Georgios Tzikos, Gerardo Perrotta, Gerfried Teufelberger, Germain Ahlonsou, German Minguez, Geta Maharaj, Gezim Galiqi, Ghada Elhoseny, Ghada Saied Nagy, Ghiath Al Saied, Ghina Shamim Shamsi, Giacomo Nastri, Giacomo Pata, Gianfranco Cocorullo, Gianluca Curletti, Gianluca Pagano, Gianluca Pellino, Gianmaria Confalonieri, Gianpiero Gravante, Giedrius Lauzikas, Giles Dawnay, Gintaras Simutis, Giorgio Vasquez, Giovanni Landolfo, Giovanni Lazzari, Giovanni Luca Lamanna, Giovanni Pascale, Giovanni Pesenti, Giovanni Sgroi, Giridhar H Devadasar, Gisele Moreira, Giuliano Borda-Luque, Giuseppe Clerico, Giuseppe Rotunno, Giuseppe Salamone, Giuseppe Sammarco, Gokhan Lap, Greg Padmore, Gregorio Tugnoli, Gregory Kouraklis, Greta Mclachlan, Greta Wood, Greta Žiubrytė, Guillaume Podevin, Guillermo Sanchez Rosenberg, Guo Liang Yong, Gurdeep Singh Mannu, Gurpreet Singh Banipal, Gustavo Miguel Machain Vega, Gustavo Peixoto Soares Miguel, Gustavo Pereira Fraga, Gustavo Recinos, Gustavo Rodolfo Pertersen Servin, Haaris A Shiwani, Hadeel Al-Farram, Hafiz Hakim, Hagar Zidan, Hager Abdul Aziz Amin, Hager Abdulaziz, Hager Ahmed El-Badawy, Hager Elwakil, Hager Tolba, Hagir Zain Elabdin, Haidar Hajeh, Hala Ahmed, Hala Saad, Halima Aliyu, Hamdi Ebdewi, Hamza Asumah, Hamza Waleed, Hanan Adel Saad, Haney Youssef, Hani Natalie, Hanna Royson, Hannah Anderson-Knight, Hannah Burns, Hannah S Thomas, Hans-Ivar Pahlsson, Harish Neelamraju Lakshmi, Harriet Jordan, Hasan Ismael Ibraheem, Hasan Ismael Ibraheem Al-Hameedi, Hasbi Maulana Arsyad, Hasnain Abbas Dharamshi, Hassan Ali Mostafa, Hatem El-Sheemy, Haya Tahboub, Hayam Ahmed, Hayden Kretzmann, Hayssam Rashwan, Haytham Abudeeb, Hazem Khaled, Hazmi Dwinanda Nurqistan, Heather Bougard, Heba Baraka, Heba Gamal, Heba Shaker, Hector Shibao Miyasato, Helen Mohan, Helen Woodward, Helena Franco, Helene Francois-Coridon, Helmut Alfredo Segovia Lohse, Hend Adel Gawad Shakshouk, Hend Kandil, Hend Mahmoud, Henri Kotobi, Henry Mendel, Henry Nnaj, Herlin Karismaningtyas, Herman Cruz, Hesham Magdy, Hesham Mohammed Bakry, Hian Ee Heng, Hildur Thorarinsdottir, Hisham Safa, Hisham Samih, Hogea Mircea, Hong Kong Sar, Hong Yee Wong, Hoong-Yin Chong, Hope Edem Kofi Kordorwu, Hope Glover-Addy, Horacio Paredes Decoud, Hosni Khairy Salem, Hossam Dawoud, Hossam Elfeki, Hossam Emadeldin, Houda Bachri, Hunain Shiwani, Hussein Ali, Hussein El-Kashef, Hussein Mohammed, Hussien Ahmed, Iason-Antonios Papaskarlatos, Ibrahem Abdelmotaleb, Ibrahim AbdelFattah, Ibrahim Alhabli, Ibrahim Al-Slaibi, Ibrahim AlYoussef, Ibrahim Elzayat, Ibrahim Elzayyat, Ibrahim N Alomar, Ibrahim Rakha, Ibrahim Raza, Ida Björklund, Idelso Vasquez, Ignas Rakita, Ihab Hassan, Ihdaa Adawi, Iloba Njokanma, Iman Elkadsh, Immacolata Iannone, Ingemar Havemann, Ioannis Kyriazanos, Ioannis Patoulias, Ioannis Valioulis, Ionasc Dan, Ionut Negoi, Ionut-Bogdan Diaconescu, Irene Montes, Irene Ortega-Vazquez, Isaac Amole, Isaac Bertuello, Isaac Hanley, Isam Bsisu, Islam Magdy El Sayed, Ismael Isaac Zelada Alvarez, Ismail Lawani, Israa Abdullah Aziz Al-Azraqi, Israa Adel, Israa Awad, Israa Qawasmi, Ivan Mendoza Restrepo, J Edward Fitzgerald, Jack Almy, Jacqueline Sheehan, Jaime Andres Montoya Botero, Jaime Herrera-Matta, Jakeline Restrepo, Jakov Mihanovic, James Adeniran, James Brown, James Davies, James Giles, James Glasbey, James Olivier, James Pape, James Richards, James Wheeler, James Yang, Jamie Shah, Janet Pagnozzi, Jannin Salcedo, Jasim Amin, Jason Brown, Javier Pastora, Javier Rosales, Jazmin Coronel, Jean Bréaud, Jean De La Croix Allen Ingabire, Jean-Baptiste Marret, Jean-Francois Colombani, Jean-François Lecompte, Jeffrey Dalli, Jehad Hassan Youssif, Jehad Meqbil, Jemina Onimowo, Jen Cornick, Jenifa Jeyakumar, Jennifer Nowers, Jennifer Rickard, Jennifer Skehan, Jerry Makama, Jesse Ron Swire Ting, Jessica Juliana Tan, Jessica Patricia Gonzales Stuva, Jessica Roth, Jessica Souza Luiz, Jia Hao Law, Jia Yng Siaw, Jian Er Saw, Jibran Abbasy, Jiheon Song, Jimy Harold Jara Quezada, Joachim Amoako, Joachim Wiborg, Joanna Swann, Jo-Anne Carreira, Joanne Edwards, Joe Vincent, Joel Kin Tan, Joe-Nat Clegg-Lamptey, Johanna Joosten, Johanna Nyberg, Johannes Kurt Schultz, Johannes Wiik Larsen, John Bondin, John F Camilleri-Brennan, John Jemuel V Mora, John Lee Y Allen, John Whitaker, Jolanta Gribauskaite, Jon Arne Søreide, Jon Kristian Narvestad, Jonathan Ajah, Jonathan Dakubo, Jonathan Heath, Jonathan R L Wild, Jonny Setiawan, Jorge Armando Chungui Bravo, Jorge Torres Cardozo, Jose Aguilar-Jimenez, Jose Andres Garcia-Marin, Jose Antonio Cabala Chiong, Jose Costa-Maia, José Hamasaki, José Luis Hamasaki Hamaguchi, Jose Luis Rodicio, Jose María Vergara Celis, José René Arévalo Azmitia, Joselyn Ye, Joseph Awuku-Asabre, Josephine Psaila, Joshua Luck, Joshua Michael Clements, Joyeta Razzaque, Juan Camilo Correa, Juan Carpio, Juan Gouws, Juan Jaime Herrera Matta, Juan Manuel Carmona, Juan Marcelo Delgado, Juana Kabba, Jubran J Al-Faifi, Julia Guasti Pinto Vianna, Julian Camilleri-Brennan, Juliana Menegussi, Julien Leroux, Julien Rod, Juliette Hascoet, Julio Jimenez, Junyeong Oh, Juozas Kutkevicius, Justas Kuliavas, Justas Žilinskas, Justin Chak Yiu Lam, Justus Lando, Ka Hin Gabriel Li, Ka Wai Leung, Kai Yin Lee, Kalangu Kabongo, Kalitha Pinnagoda, Kalon Hewage, Kamau Kinandu, Kamran Faisal Bhopal, Kandasami Palayan, Kareem Dabbour, Kareem Elshaer, Karen Bailey, Karim Hilal, Karl Bonavia, Karolis Lagunavicius, Karolis Varkalys, Kate Cross, Kate Yu-Ching Chang, Katharina Beate Reinisch, Katharine Whitehurst, Katherine Gash, Kathryn Chu, Kathryn Lee, Katie Connor, Katrin Gudlaugsdottir, Kaustuv Das, Kazeem Atobatele, K C Janardha, Kean Leong Koay, Keat-Seong Poh, Keiran David Clement, Keith Sammut, Keith Say Kwang Tan, Kenneth Aaniana, Kenneth Johnson, Kenneth Mealy, Kenneth Thorsen, Kenny Turpo Espinoza, Kent Pluke, Kestutis Strupas, Kevin C Conlon, Kevin Turpo Espinoza, Khaled Abozeid, Khaled Alhady, Khaled Aljboor, Khaled Dawood, Khaled Hesham Elbisomy, Khaled Ibrahim, Khaled Khattab, Khaled Naser El Deen, Khalid Mahmud, Khalid Qurie, Khalid Salah El-Dien, Khalil Abdul Bassit, Khaoula Boukhal, Khlood Ashour, Kholod Tarek Lasheen, Kholoud Abdelbadeai, Khurram Khan, Khuzaimah Zahid Syibrah, Kieran Atkinson, Kieran Ka Kei Li, Kirsten Lafferty, Kjetil Søreide, Knut Magne Augestad, Kolonia Konstantina, Konstantinos Farmakis, Konstantinos Gasteratos, Kornelija Maceviciute, Kpèmahouton René Keke, Kresimir Zamarin, Kristian Styles, Kristijonas Jasaitis, Kristijonas Jokubonis, Kristina Cassar, Kuet Jun Chung, Kuhaendran Gunaseelan, Kuok Chung Lee, Kurt Carabott, Kwabena Agbedinu, Kwaku Boakye-Yiadom, Kwame Maison, Kwasi Asare-Bediako, Kwasi Kusi, Kyaw Phyo Aung, Kylie Joan-Yi Szeto, Kyriakos Psarianos, Laimonas Uščinas, Lalith Asanka Jayasooriya Jayasooriya Arachchige, Lana Abusalem, Larissa Ines Páez Lopez, Lau Wen Liang Joel, Laura Gavagna, Laura Koskenvuo, Laura Lorenzon, Laura Luque, Laurent Fourcade, Lawal Abdullahi, Lawani Ismaïl, Lawrence Bongani Khulu, Layza-Alejandra Mercado Rodriguez, Lee Shi Yeo, Leif Israelsson, Lemuel Davies Bray, Lenin Peña, Leo Licari, Leonardo Solaini, Li Jing Yeang, Liam Henderson, Liam Richardson, Liana Roodt, Lillian Reza, Linas Urbanavicius, Linas Venclauskas, Linda Alvi Madrid Barrientos, Linda Andersson, Ling Wilson, Linn Nymo, Linnea Mauro, Liviu Iuliu Muntean, Liviu Muntean, Ljiljana Jeremic, Lofty-John Anyanwu, Lopna Ahmed Mohamed Ahmed, Lorena Fuentes-Rivera, Lorena Rodriguez, Lorena Solar García, Lorraine Sproule, Lotfy Eldamaty, Luai Jamal, Luana Ayres Da Silva, Lubna Sabeeh, Luc Hervé Samison, Luca Ansaloni, Luca Bortolasi, Luca Turati, Lucia Duinhouwer, Lucian Corneliu Vida, Lucile Fievet, Lucio Selvaggi, Ludwing Alexander Zeta Solis, Luen Shaun Chew, Luigi Bonavina, Luigi Bucci, Luigi Maria Cloro, Luis Alberto Valente Laufer, Luis Barneo, Luis Joaquín García Florez, Luis M Helguero-Santin, Luis Miguel Alvarez Barreda, Luis Tale, Luisa Giavarini, Luiz Carlos Barros De Castro Segundo, Luiza Sarmento Tatagiba, Lukas Eisner, Lusi Padma Sulistianingsih Mata, Maarten Vermaas, Mabel Amoako-Boateng, Maciej Walędziak, Madan Jha, Madelaine Gimzewska, Mads Gran, Maeve O'neill, Magdalini Mitroudi, Magnus Boijsen, Maha Al-Faqawi, Maha Elmasry, Maha Gamal Mohamad Hamad, Maha Nasr, Mahadevan Deva Tata, Mahitab Essam, Mahitab Morsy Farahat, Mahmoud A Elnajjar, Mahmoud Abdelshafy, Mahmoud Abdelshakour, Mahmoud Abdulgawad, Mahmoud Ahmed Fathi Abozyed, Mahmoud Alrahawy, Mahmoud Amreia, Mahmoud Badawy, Mahmoud Eldafrawy, Mahmoud Elfiky, Mahmoud Elkhadragy Maher, Mahmoud Elkhadrawi, Mahmoud Elsayed Moghazy, Mahmoud Gomah, Mahmoud M Saad, Mahmoud Mohamed Metwally, Mahmoud Morsi, Mahmoud Saad, Mahmoud Saami, Mahmoud Salama, Mahmoud Salma, Mahmoud Shalaby, Mahmoud Warda, Mahmoud Zakaria, Mahmut Arif Yuksek, Mahnoor Javaid, Mahnuma Mahfuz Estee, Mai Ebidy, Mai Mohamed Ebidy, Mai Salama, Maíra Cassa Careta, Maja Marcus, Majd Dabboor, Majed Aboelella, Makafui Dayie, Makki Elsayed, Malcolm Falzon, Maleeha Hassan, Malin Sund, Man Fung Leung, Man Hon Andrew Yeung, Manar Abd-Elmawla, Manar Saeed, Mantas Drungilas, Mantas Jokubauskas, Mantas Vilčinskas, Manuel Francisco Roxas, Manuel Hache-Marliere, Manuel Lopez, Manuel Rodriguez Castro, Manuela Mendez, Manzoor Dar, Maram Abu-Toyour, Maram Salah, Marcelo O Higgins Roche, Marco Catani, Marco Maria Pascale, Marco Migliore, Mardelangel Zapata Ponze De Leon, Margaret O'Shea, Margarita Montrimaite, Margherita Notarnicola, Margub Hussain, Maria Clara Mendoza Arango, Maria Giovanna Grella, Maria Hjertberg, Maria Isabel Villegas Lanau, Maria Jesusa B Maño, Maria Lorena Aguilera, Maria Marta Modolo, Maria Mayasari, Maria Novella Ringressi, Maria Soledad Gonzales Montejo, Maria Soledad Merlo, Maria Utter, María Valcarcel-Saldaña, Maria-Lorena Aguilera-Arevalo, Mariam Darweesh, Mariam O Gad, Mariam Saad Aboul-Naga, Mariano Cesare Giglio, Mariastella Malavenda, Marie Carmela Lapitan, Marie Dione Parreno-Sacdalan, Marie Paul, Mariette Renaux-Petel, Marija Agius, Marilia Del Carmen Escalante Salas, Marilla Dickfos, Marina Luiza Pimenta, Mario Contreras Urquizu, Mario Corbellino, Mário Jacobe, Mario Lopez, Mario Pasini, Mario Trompetto, Marisa Leal, Marisol Manriquez-Reyes, Mariuca Popa, Mark Ian Hampton, Mark Sykes, Mark Wagener, Markus Zuber, Marte Bliksøen, Martha Glynn, Martin Jarmin, Martin Kyereh, Martina Perino, Martina Yusuf Shawky, Martinique Vella-Baldacchino, Marvin Vargas, Marwa Altarayra, Marwa Elashmawy, Marwa Elshobary, Marwa Hamdan, Marwa Sayed, Marwan Abubakr, Marwan Fahim, Marwan Shawki, Maryam Ali Khan, Maryna Shubianok, Mashael Al-Mousa, Masood Alghamdi, Masood Jawaid, Massiell Machaca, Massimiliano Dal Canto, Massimo Coletti, Matas Pažuskis, Matei Bratu, Matei Razvan Bratu, Mateusz Rubinkiewicz, Matteo Papandrea, Matteo Ripa, Mattew Ekow, Matthew Baldacchino, Matthew Billy, Matthew Young-Han Kim, Matthieu Peycelon, Matti Tolonen, Maureen Bezzina, Maurizio Foco, Mawaddah Alrajraji, Max Dénakpo, Max Rath, Mayaba Maimbo, Mazed Mohamed, Mazen Hassanain, Megan Turner, Mehmet Ali Yavuz, Mehmet Gumar, Mehmet Uluşahin, Melanie Castro Mollo, Melanie Zapata Ponze De Leon, Menatalla Salem, Mengistu Worku, Menna Tallah Ramadan, Mennaallah Hafez, Mennat-Allah Mustafa, Menold Archee P Redota, Meran Allam, Meric Mericliler, Merna Mostafa, Meryem Abbouch, Metwally Aboraya, Michael Amoah, Michael Cox, Michael Edye, Michael Gillespie, Michael Hanrahan, Michael Livingston, Michael Puttick, Michael Stoddart, Michael Van Niekerk, Michael Walsh, Michael Wilson, Michail Kontos, Michail Margaritis, Michał Janik, Micheal Ohene-Yeboah, Michela Monteleone, Michele Carlucci, Michele Sacco, Michelle Mccarthy, Midhun Mohan, Miguel Angel Paludi, Miguel Siguantay, Mihael Radic, Mihaela Vartic, Miklosh Bala, Milaksh Kumar Nirumal, Milan Radojkovic, Milica Nestorovic, Millika Ghetia, Mindaugas Kiudelis, Mircea Beuran, Mircea Hogea, Mirko Mangiapane, Mitchelle Solange De Fã Tima Linares Delgado, Moayad Othman, Mobolaji Oludara, Modise Zacharia Koto, Mohamad Baheeg, Mohamad Bakhaidar, Mohamad Jeffrey Bin Ismail, Mohamed A Abdelaziz, Mohamed A Amer, Mohamed A Baky Fahmy, Mohamed Abbas, Mohamed Abd El Slam, Mohamed Abdelaty, Mohamed Abdelaty Mohamed, Mohamed Abdelkhalek, Mohamed Abdelraheim, Mohamed Abozaid, Mohamed Abozed Abdullah, Mohamed Abuseif, Mohamed Adel Badenjki, Mohamed Ali Ghonaim, Mohamed Ali Mahmoud, Mohamed Ameen, Mohamed Ammar, Mohamed Asal, Mohamed Awad Elkarim Hamad Mohamed, Mohamed Dablouk, Mohamed El Halawany, Mohamed Elazoul, Mohamed Elbermawy, Mohamed Elfil, Mohamed Elsehimy, Mohamed Elzayat, Mohamed Etman, Mohamed F Zalabia, Mohamed Fares, Mohamed Fawzy Mahrous Badr, Mohamed Fouad Hamed, Mohamed Gadelkarim, Mohamed Ghoneem, Mohamed Gulamhussein, Mohamed Hafez, Mohamed Hashish, Mohamed Hassab Alnaby, Mohamed Husseini, Mohamed Ibrahim, Mohamed Ismail, Mohamed Karkeet, Mohamed Kelany, Mohamed Mabrouk, Mohamed Magdy, Mohamed Mahmoud, Mohamed Moamen Mohamed, Mohamed Moaty, Mohamed Mostafa, Mohamed Mustafa, Mohamed Nashat, Mohamed Nazir, Mohamed Reda Loaloa, Mohamed Rezal Abdul Aziz, Mohamed Sabry Ammar, Mohamed Salah, Mohamed Salah Elhelbawy, Mohamed Seisa, Mohamed Shaalan, Mohamed Sleem, Mohamed Sobhi Jabal, Mohamed Youssef, Mohamed Zidan, Mohamedraed Elshami, Mohammad Abdulkhalek Habeeb, Mohammad Aboraya, Mohammad Adawi, Mohammad Alherz, Mohammad Aliyu, Mohammad Elsayed Omar, Mohammad Ghannam, Mohammad Ghassan Alwafai, Mohammad Mohsin Arshad, Mohammad Rashid, Mohammadasim Amjad, Mohammed Alamoudi, Mohammed Alhendy, Mohammed AlRowais, Mohammed Alsaggaf, Mohammed Alzahrani, Mohammed Bukari, Mohammed Deputy, Mohammed Elgheriany, Mohammed Elsayed, Mohammed Elshaar, Mohammed Elsiddig, Mohammed Firdouse, Mohammed G Azizeldine, Mohammed Hanafy, Mohammed Ismail, Mohammed Kamal Ismail, Mohammed Mousa, Mohammed Mousa Salem, Mohammed Mustafa Hassan Mohammed, Mohammed Mustafa Mohammed, Mohammed Najjar, Mohammed Nasr, Mohammed Osman, Mohammed Osman Dablouk, Mohammed Saeed, Mohammed Saleh A Alghamdi, Mohammed Ubaid Alsaggaf, Mohammed Yahia Mohamed Aly, Mohannad Aledrisy, Mojolaoluwa Olugbemi, Mona Hamdy Madkor, Mona Hosh, Mona Rashad, Monica Bassem, Monique Moron Munhoz, Monty Khajanchi, Morgan Haines, Morvarid Ashtari, Mostada Samy, Mostafa Abdelkader, Mostafa Ahmed Bahaa Eldin, Mostafa Allam, Mostafa Gemeah, Mostafa Mahmoud Eid, Mostafa Qenawy, Mostafa Samy, Mostafa Seif, Mostafa Shalaby, Mousa Mustafa, Moustafa Ibrahim Mahmoud, Moustafa R Aboelsoud, Msafiri Kimaro, Muayad Ahmed Alfarsi, Muhamed M H Farhan-Alanie, Muhammad Adil, Muhammad Alkelani, Muhammad Amsyar Auni Lokman, Muhammad Bin Hasnan, Muhammad Daniyan, Muhammad El-Saied Ahmad Muhammad Gohar, Muhammad Fathi Waleed Omar, Muhammad Habib Ibrahim, Muhammad Mohsin Furqan, Muhammad Rashid Minhas Qadir, Muhammad Saqlain, Muhammad Shawqi, Muhammad Talha Butt, Muhammad Taqiyuddin Yahaya, Muhammad Waqar, Muhammed Masood Riaz, Muhammed Talaat, Muhtarima Haque, Muna Rommaneh, Murad Aljiffry, Murat Karakahya, Musah Yakubu, Muslimat Alada, Mustafa Farhad, Mustafa Mohammed Taher, Muthukumaran Rangarajan, Muwaffaq Mezeil Telfah, Myint Tun, Myranda Attard, Nada Ahmed Reda Elsayed, Nada El-Sagheer, Nada Elzahed, Nada Mohamed Bekhet, Nader Abd El Hamid, Nadia Khalid Abd El-Latif, Nadia Ortiz, Nadin Elsayed, Nadya Johanna, Nahilia Carrasco, Najwa Nadeem, Naomi J Wright, Napoleon Mendez, Narimantas E Samalavicius, Nashat Ghandora, Nasir Bustangi, Natale Di Martino, Natalie Blencowe, Natalie Redgrave, Nathalie Botto, Nathania Sutandi, Nawal Sadig, Nazmie Kariem, Nebil Behar, Nebiyou Seyoum Abebe, Nebyou Seyoum, Nebyou Seyoum Abebe, Neel Gobin, Neel Limaye, Neerav Aruldas, Nehal Yosri Elsayed Abdel-Wahab, Neil Smart, Nelson Manuel Urbina Rojas, Nelson Msiska, Nerijus Kaselis, Nermeen Soubhy El-Shahat, Nermin M Badwi, Nermin Mohamed Badwi, Nesma Elfouly, Nicholas Phillips, Nichole Starr, Nicola Chetta, Nicola Zanini, Nicolas Henric, Nicole D'aguzan, Nicole Grech, Nicoleta Panait, Nicoletta Leone, Nicolò Falco, Nidhi Gyanchandani, Nigel J Hall, Nihaal Shaikh, Niiarmah Adu-Aryee, Nik Azim Nik Abdullah, Nik Ritza Kosai, Nikica Pezelj, Nikki Green, Nikolaos Gouvas, Nikolaos Ivros, Nikolaos Mitroudis, Nikolaos Nikoloudis, Nikolaos Zampitis, Nithya Niranjan, Niveshni Maistry, Noha Abdullah, Noha Abdullah Soliman, Noha Maraie, Noha Wael, Nohad Osman, Noman Shahzad, Nora Abdul Aziz, Norah Al Subaie, Noran Abdel-Hameed, Noran Halim El Gendy, Norbert Uzabumwana, Norberto Herrera, Norma Depalma, Nosisa Sishuba, Nouf Akeel, Noura A Attallah, Nourhan Adam, Nourhan Anwar, Nourhan Elsabbagh, Nourhan Medhat Elhadary, Nourhan Mesbah, Nourhan Semeda, Nourhan Soliman, Novia Adhitama, Nowrin F Aman, Nuno Muralha, Nur Zulaika Riswan, Nurlaila Ayu Purwaningsih, Nyawira Ngayu, Octavio Garaycochea, Oday Halhouli, Ogechukwu Taiwo, Ola Sherief Abd El Hameed, Olabisi Osagie, Olabode Oshodi, Olajide Abiola, Olalekan Ajai, Oliver Warren, Oliver Ziff, Olivier Abbo, Olivier Azzis, Olivier Rosello, Olubukola Faturoti, Olufemi Habeeb, Olumide Elebute, Oluseyi Ogunsua, Oluwaseyi Adebola, Oluwatomi Odutola, Omar Abdelkader, Omar Abdulbagi, Omar Aguilera, Omar Alahmady, Omar Arafa, Omar Ghoneim, Omar Hesham, Omar Mattar, Omar Moussa, Omar Osman, Omar Salah, Omar Saleh, Omnia Aboelmagd, Omnia Mosalum, Omobolaji O Ayandipo, Omolara Faboya, Omolara Williams, Opeoluwa Adesanya, Orestis Ioannidis, Osaid H Alser, Osama Algohary, Osama Mohamed, Osama Mohamed Salah, Osama Mokhtar Mohamed Hassan, Osama Saadeldeen Ebrahim, Osama Seifelnasr, Osman Imoro, Ossama Al-Obaedi, Otto Coyoy-Gaitan, Ourdia Bouali, Owusu Emmanuel Abem, Oyediran Kehinde Timothy, Oyindamola Oshati, Pablo Ramazzini, Pål Aksel Næss, Pamphile A Assouto, Panchali Sarmah, Pandi Eduard, Panu Mentula, Paola Salusso, Paola Violi, Paolino De Marco, Paolo Aonzo, Paolo Silvani, Paolo Ubiali, Patrizio Mao, Paul Kielty, Paul Sutton, Paul Ugalde, Paul Witherspoon, Paul Wondoh, Pauline Gastaldi, Paulius Karumnas, Paulius Kondrotas, Paulo Alves Bezerra Morais, Pedro Angel Toribio Orbegozo, Peep Talving, Pei Ying Koh, Per Weber, Per-Olof Lundgren, Peter Deutschmann, Peter Labib, Peter Wiel Monrad-Hansen, Petras Višinskas, Phebe Anggita Gultom, Philip Alexander, Philip Choi, Philip Mshelbwala, Philip Taah Amoako, Philippe Buisson, Phoebe De Bono, Phumudzo Ndwambi, Pier Paolo Grandinetti, Piergiorgio Danelli, Pierpaolo Sileri, Pietra Ligure, Pietro Mingrone, Pigeneswaren Yoganathan, Piotr Major, Poddevin Francois, Povilas Ignatavicius, Povilas Mazrimas, Prasad Pitigala Arachchi, Pratik Jain, Prince Kwakyeafriyie, Prisca A L Har, Pui Xin Chin, Puneet Malik, Puyearashid Nashidengo, Qinyang Liu, Quentin Alimi, Quentin Ballouhey, Quinn Ellison, R Goh Ern Tze, Rachel King, Rachel Moore, Radhian Amandito, Radin Mohd Nurrahman Radin Dorani, Rafael Araujo, Rafael Soley, Rafał Roszkowski, Raffaele Galleano, Ragavan Narayanan, Ragnar Herikstad, Rahma Kamil, Rajeev Satoskar, Rakan Kabariti, Ralph F Staerkle, Ram Nataraja, Ramadan Oumer, Ramadan Shaker, Ramdan Shaker, Ramesh Jonnalagadda, Ramon Alvarado Jaramillo, Ramón Augusto Melo Cardozo, Rana Mamdouh, Rana Saadeh, Raquel Rodríguez-Uría, Raquillet Claire, Rasha Abdelhamed, Razvan-Matei Bratu, Reda Žilinskienė, Redouane Mammar Bennai, Reem Alyahya, Reem Fakher, Reem Husseiny, Reem Khreishi, Reem Mohammed Hassan Balila, Rehab Elashry, Reham Alaa El-Din, Reham Alshareef, Reham Saad, Renato Melo, Reuban D'cruz, Reuben Goh Ern Tze, Reynu Rajan, Rezaul Karim, Ricardo Velasquez, Richard Gilbert, Richard Lilford, Richard Opoku-Agyeman, Richard Spence, Richard William Gilbert, Richmond Hagan, Rifan Alyami, Riinu Ots, Ritauras Rakauskas, Roaa Khan, Robert George, Robert Karlo, Robert Kerley, Robert Mcintyre, Robert Morton, Robert Parker, Robert Tyler, Roberta Bugeja, Roberta Tutino, Roberta Villa, Robertas Baltrunas, Robertas Pranevicius, Roberto Cautiero, Roberto Cirocchi, Roberto Faccincani, Roberto Klappenbach, Roberto Macchiavello, Roberto Peltrini, Roberto Schiavone, Robinson Mas, Roel Matos-Puig, Rofida Elsemelawy, Roger Lawther, Roger Schmid, Rohan Ardley, Rohi Shah, Rokas Rackauskas, Rokayah Julaihi, Rokia Sakr, Roland Osuoji, Romeo Guevara, Romeo Lages Simoes, Romualdas Riauka, Ronald Coasaca Huaraya, Ronald Renato Barrionuevo Ojeda, Ronan Cahill, Rony Camacho, Rory Callan, Rosario Sacco, Rose Khreishi, Rosie Mcdonald, Ross Bowe, Ross Coomber, Rowida Elmelegy, Roxanne Chenn, Roy Quek, Rubén Balmaceda, Rubén Darío Arias Pacheco, Ruben Rivas, Ruben Santiago Restrepo Giraldo, Rudy Gunawan, Rula Zaa'treh, Ruqaya Kadhim Mohammed Jawad Al-Hasani, Ruta Mazelyte, Ruth Blanco, Ruth Gratton, Ruth Scicluna, Ryan Adams, Ryan Choon Kiat Tan, Ryan Mcintosh, S V Kinnera, Saad Al Awwad, Sabbir 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Abdelrouf, Doaa, Pata, Domenica, Mapasse, Domingo, Charles Marshall, Dominic, B O'Connor, Donal, Danys, Donata, Venskutonis, Donata, Radkowiak, Dorota, Bowley, Doug, Majauskyté, Dovilè, Irusha Samaraweera, Dulan, Lacthman Jethwani, Durvesh, Iyer, Dush, Iyer, Dushyant, Khokha, Dziani, Paulouski, Dzmitry, Takyi Atkins, Ebenezer, Anis, Echaieb, Domini, Edgar, Temoche, Edilberto, Huaman, Eduardo, Grisin, Edvard, Dainius, Edvina, Thomas, Efeson, Preckailaite, Egle, Alnawam, Ehab, Mamdouh, Ehab, Kjus Aahlin, Eirik, Kefalidi, Eirini, Mensah, Ekow, Borg, Elaine, Prisca Refianti Sutanto, Eldaa, Marks, Eleanor, Goldin, Elena, Muzio, Elena, Vendramin, Elena, Zdanyte Sruogiene, Elena, Ciccioli, Eleonora, Jovine, Elio, Francone, Elisa, Jensen, Elisabeth, Rifhan Mohd Basir, Elissa, Snyder, Elizabeth, Teasdale, Ella, Akoto, Elliot, Gaignard, Elodie, Haraux, Elodie, Robert, Elsa, Ali, Elsayed, Gamaly, Elsayed, Abdallah, Emad, Al-Dakka, Emad, Ali Ahmed, Emad, Aljohani, Emad, Mohamed Saeed Taha, Emad, 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A.B., Al-Shammari A., Gendy A.E., Esam A., Marey A., Mittal A., Yifieyeh A., Bin Mahamood A., Adesuyi A., Aly A.K., Nawawi A., Gyedu A., Waterman A., Osinowo A., Fatuga A., Albiety A., Hassanein A.B., Denewar A., Adekoya A., Adebanjo A., Adeyeye A., Popoola A., Adedeji A., Ademuyiwa A.O., Tade A., Adeniyi A., Adisa A.O., Tarek A., Ladukas A., Palma A.F., Hasanah A., Salleh A., Abdelfatah A., Altamini A., Fitsum A., Taiwo A., Hassan A., Ghaben A., Fattah A.A., Al Rafati A.A.R., Ibrahem A.A., Aldalaq A., Ali A., Almallah A., Alrifaie A., Ashour A., Bakr A., Bani-Sadar A., Bin Adnan A., Elbatahgy A., Faraz A., Gudal A., Hasan A., Sabe A.K., Khoja A., Nashaat A., Qaissieh A., Sabe A., Sleem A.S., Sakr A., Shalabi A., Qureshi A.U., Aamer A., El Galeel A.A., Elhusseiny A.A.E., Elsameea A.A., Abdelkareem A., Ghazy A.A., El Magd A.A., Elazayem A.A., Adamu A., Afandy A., Ahmed A., Alghamdi A., Al-Khatib A., Altibi A., Alzahrani A., Ata A., Badr A., Dahy A., Diab A., Kashash A.E., Kholy A.E., Musa A.E.K., Elgebaly A., Elkelany A., Elkholy A., El-Sehily A., Essam A., Fahiem A., Farag A., Fawzy A., Fouad A., Gad A., Ghanem A., Gheith A., Gomaa A., El-Badri Kotb A.H., Hammad A., Rida A.H.E.F., Ismail A., Karim A., Khyrallh A., Lasheen A., Rashed A.M., Magdy A., Abdelraouf A.M., Menshawy A., Meshref A., Afifi A.M., Ibrahim A.M., Mohameden A., Mokhtar A., Mosad A., Moustafa A., Saeed A.M., Negida A., Mohammed A.R., Mohamed A.R., Nayel A.R., Soliman A.R., Raslan A., Raza A., Refaat A., Rslan A., Sabry A., El-Hamouly A.S., Marey A.S., Saidbadr A., Samir A., Shahine A., Sheta A., Tammam A., Hassan A.T.A., Shamsedine A.W., Zaki A., Eldeeb A.Z., Zohair A., Kandil A.M., Elnagar A., Zil-E-Ali A., Jabbar A., Snaith A.C., Costas-Chavarri A., Austraite A., Mistry A., Olaolorun A., Ajao A.E., Jubran A.F., Shamasneh A., Abouelnasr A., Al-Buhaisi A., Bowabsak A., Jamassi A.E., Elazab A., Elhadad A., Fergany A., Habeebullah A., Shabkah A., Shaheen A., Adesina A., Baird A., Grant A., Ball A., Cacurri A., Mphatsoe A.M., Luc A.R., Matheu A., Munera A., Bedada A.G., Favero A., Maniscalco A., Calua A.C., Fowler A.J., Gerosa A., Horobjowsky A., De Sousa A.V., Farrugia A., Arnaud A.P., Russo A.A., Gulielmi A., Ababneh A., El Dahab A.A., Ata A.A.A., Niazi A.K., Kiasat A., Hammad A.M., Zardab A., Balkan A.Z.A., Toeema A.G., Sadek A., Filatau A., Latif A., Suarez A.A.B., Faure A., Niragire A., Robledo-Rabanal A., Broch A., Hasheminia A., Macdonald A., Ndajiwo A., Novak A., Mutabazi A.Z., Beleno A.E.M., Cheah A.E.Z., Elrazek A.A., Nasr A., Sanad A., Elgendy A.H., Cury A.D.L., Ibrahim A., Martin A., Althwainy A., Abouzahra A., Mohammed A.E., Kourdouli A., Hashish A., Birring A., Al Meligy A., Abdelhamid A., Majid A.H.H.A., Mohammad A., Kaci A.A., Omar A.A., Elsawy A., Bekhet A.H., Reda A., Qumbos A.A., Elmashala A., Gado A., Mohamed A.M., Mohamed A., Rasendran A., Saleh A.A., Fadel A., Hassaan A., Hossameldin A., Elkorashy A.M., Hafez A.T., Faruq A., Aglan A., Bautista A.C.M., Contreras-Vergara A.L., Barrantes A.M.S., De Freitas A.V.C., Freitas A.V., Rashid A., Abdelazeam A.R., Kirishnan A., Majbar A., Bamicha A., Stefanopoulos A., Thorell A., Das A., Dubois A., Mihaljevic A.L., Navarro A., Allegri A., Armellini A., Belli A., Bondurri A., Moran A.E.R., Natili A., Ruzzenente A., Simioni A., Haloho A., Tanase A., Kolosov A., Subocius A., Robertson A.G.N., Kirby A., McGuigan A., Spina A., Litvin A., Burmistrovas A., Strazdas A., Arenas A., Bhangu A., Rudzenskaite A., Rojas A.D.P., Dell A., Mejia A.G.V., Charles A., Antoniozzi A., Benevento A., Tselos A., El-Ma'doul A.S., Sreedharan A., Bhatnagar A., Kjellin A., Lasek A., Maffioli A., Powell A., Rinaldi A., Watts A., lo Conte A., Bigaran A., Ashton A., Mukin A.D.F., Gulbinas A., Zadoroznas A., Rulie A.S., Ajiboye A., Avoka A., Lai A.C.-H., Davor A., Sander A., Oosterkamp A., Bediako-Bowan A., Brocca A.L., Leal A., Nocito A., La Medina A.R.-D., Taddei A., Atiyeh A., Kojo A.T.T., Driscoll A., Shah A., Vlachogiorgos A., Roslani A.C., Abdelhaq A., del Pilar Paucar A., Picciariello A., Kanani A., Leppaniemi A., Birindelli A., Nesaratnam A., Suyadi A., Velasquez A.J.R., Bonnard A., Agarwal A., Alkaaki A., Vaicius A., Khamajeet A., Reinsoo A., Abouzaid A., Elfarargy A., Kedar A., Alnusairat A., Hamarshi A., Musleh A., Prabhudesai A., Maghrabi A.A., Morsi A., Mitul A.R., Abdelgelil A., Al-Aarag A.A.-R., Rezq A., Salah A., Papailia A., Badwy A., Leusink A., Khan A., Eysa A., Zulkifli A., Mahdi A., Attia A., Attia A.M., Clarissa A., Dulskas A., Parseliunas A., Zani A., Tun A.K., Mironescu A., Mironescu A.S., Scalabre A., Mariani A., Haffreingue A., Thollot A., Usaityte A., Skardziukaite A., Ibraheem A.A.F., Aboarab A., Elsharkawy A.A., El-Sawy A., Elwaey A., Firwana A., Hagar A., Fathy A.M., Ata A.Y., Hamdan A., Taher A.A., Elwan A., Nabawi A., Salman A., Shwky A., Ogunyemi A., Herebat A., Verjee A., Adenekan B., Odeyemi B., Adel B.E., Tawfik B.A., Ozkan B.B., Mohamed B., Nighat B., Albeladi B., Malaga B., Mijuskovic B., Silvestre B.P., Kumar B., Sieda B., Bello B., Alghamdi B., Magdy B., Mahmoud B., Alhassan B., Mowafy B., Brunoni B., Weber B., Sanchez B., Thompson B., Parmentier B., Limoges B., Van Duren B., Wolf B., Dousset B., Grizhja B., Lieske B., Maillot B., Mansour B., Frisk B., Diaconescu B., Martian B.-V., Marinkovic B., Skelly B., Cameron B., Dedekind B., Noukpozounkou B., Chong B.F.H.K., Kumar B.S., de Lima C.V.B., Iacono C., Fairfield C., Samaniego C.S., Cona C., Lopez-Arevalo C., Normile C., Venugopal C., Cabrera C.C.R., Torres C.P.G., Corbellini C., Basto C.A.A., Velasquez C.I.P., Morales C., Nsengiyumva C., Galvez C.P., Capito C., Fernandez C., Diaz-Zorrilla C., Duenas C.G., Felipe C.O., Clifford C., Musyoka C.K., Shaw C.A., Magee C., Muller C., Costa C., Tolg C., Wredberg C., Del Basso C., Grosos C., Mendizabal C.A.A., Miranda C., Razuri C., Ciubotaru C., Chibuye C., Alexandre C., Szeto C.C.L., Dally C., McIntyre C.J., Benyaiche C., Chong C.L., Wong C.S., Gan C., Currow C., Deane C., Goh C.C., Koh C., Yong C.O., Khatri C., Foo C.C., Fok C.Y.J., Kong C., Ceriani C., Kwatiwani C., Yip C., Tedjaatmadja C., Chong C.S., Taieb C., Tan C.L., Bode C., Lee C., Almanon C.L., Hinojosa C., Coompson C.L., Schoewe C., Neophytou C., Major C.P., Panteli C., Mizzi C., Ferousis C., Agalianos C., Anthoulakis C., Barkolias C., Dervenis C., Chai C.-A., Wong C.Y., Fahy C., Evajelista C.V., De Emergencia C., Zarb C., Ali C.D.M., Sharpin C., Puma C.M.H., Rees C.M., Morgan C., Reali C., Arcudi C., Fermani C., Fermani C.G., Nawara C., Onuoha C., Mangan C., Sampson C., Nwokoro C., Jean-Francois C., Marinos C., Mukuzunga C., Bottini C., Gouldthorpe C., Lopez C.E., Fernandes C., Chow C.Y.N., Manipal C.E., Vimalachandran D., Alkhabbaz D., Hemeda D., Brown D., Ljuhar D., Deckelbaum D.L., Jaradat D., Du Plessis D., Soeselo D.A., Cox D., Dabessa D., Rodriguez D.E.M., Hamill D., Nel D., Youssef D., Magri D., Angelieri D., Gui D., Cruz D.H., Sale D., Gbessi D.G., Andreotti D., Kazanavicius D., McCullagh D., McNish D., Merlini D., Cohen D.M., De Boni D., Rossi D., Aziz D.N.A., Grobler D.C., Schivo D., Chiesa D., Mikuckyte D., Dragatas D., Gray D., Elsorogy D.E.A.A., Elsawahly D.M.E., Zahran D., Cadogan D.D., Sanchez D., Bandoh D., Pozo D.A.R., Antezana D., Coletta D., Romani D., Sasia D., Ofner D., Duhoranenayo D., Raptis D.A., Balalis D., Manatakis D.K., Karousos D., Korkolis D., Kyziridis D., Lytras D., Papageorgiou D., Sfougaris D., Zachariades D.-C., Al-Marakby D., Rahmah D.F., Gamal D., Tarek D., Periasammy D., dos Santos D.V., Morton D., Mirghani D., Seto D.M., Cocker D.M., Nepogodiev D., Raptis D., Emadeldin D., Gamil D., Hasan D., Hasanain D., Abdelrouf D.M., Pata D., Mapasse D., Marshall D.C., O'Connor D.B., Danys D., Venskutonis D., Radkowiak D., Bowley D., Majauskyte D., Samaraweera D.I., Jethwani D.L., Iyer D., Khokha D., Paulouski D., Atkins E.T., Anis E., Domini E., Temoche E., Huaman E., Grisin E., Dainius E., Thomas E., Preckailaite E., Alnawam E., Mamdouh E., Aahlin E.K., Kefalidi E., Mensah E., Borg E., Sutanto E.P.R., Marks E., Goldin E., Muzio E., Vendramin E., Sruogiene E.Z., Ciccioli E., Jovine E., Francone E., Jensen E., Basir E.R.M., Snyder E., Teasdale E., Akoto E., Gaignard E., Haraux E., Robert E., Ali E., Gamaly E., Abdallah E., Al-Dakka E., Ahmed E.A., Aljohani E., Taha E.M.S., Al Raouf E.A., Abdelmageed E., Abuqwaider E., Sayma E.A., Elwy E., Emara E., Hashad E., Ibrahim E., Magdy E., Hegazy E.M., Abdulhakeem E.M., Ibrahim E.M., Morshedy E.M., Nofal E., Rashad E., Mansor E.Y., Barrios E., Rausa E., Nwabuoku E., De Luca E., Eyssartier E., Dijan E., Blower E., Jurdell E., Upchurch E., Acquah E., Akatibo E., Runigamugabo E., Alaloul E., Alqahtani E., Dagoe E., Tackie E., Farinella E., Ackom E., Appiah E.K., Farfan E.S.F., Hervieux E., Schadde E., Vicario E., Laugzemys E., Ahounou E.Y.S., Elbanby E., Ezzat E., Elkhalek E.A., Kasem E.A., Eldeen E.A., El-Gizawy E., Elhalawany E., El-Taher E., Gamal E., Ghanem E., Kasem E., Elbanby E.S., Zakaria E., Hany E., Courboin E., Lee E.X., Macdonald E., Niyirera E., Grasset E., Morandi E., Panieri E., Borin E., Voulgaris E., Slapelyte E., Woin E., Macdermid E., Harrison E.M., Khalifah E., Veronese E., Deichsel F., Aquilino F., Sabour F.A., Idris F., Leong F.Q.H., Rasoaherinomenjanahary F., Ali F.M., Iftekhar F., Sayed F., Balogun F., Al Bastawis F., Asi F., Nada F., Elzowawi F., El-Salam F.A., Sroor F., Baluch F., Elgendy F.I., Elkady F., Ntirenganya F., Elsherif F.A., Mohamed F., Al Barrawi F.E., Noor F., Bianco F., Falaschi F., Coccolini F., Zheng F., Zapata F., Alakaloko F., Lee F., Chai F.Y., Iskandar F., Altoe F., Frade F., Djivoh F., Espinoza F., Fernandez-Bueno F., Tale F., Andika F.F.A., Adella F.J., Di Franco F., Rahantasoa F.C.F.P., Henry F., Rahmawati F.N., Dedey F., Primavesi F., Iordache F.-M., Lam F.Y., Koumpa F., Steccanella F., Pata F., Riente F., Giardino F.R., Selvaggi F., Abantanga F., Dossou F., Fujii F., Regalado F., Helene F.-C., Schmitt F., Gyamfi F.E., Owusu F., Aristizabal F.A.N., Hodonou F., Du Toit F., Sauvat F., Wogensen F., Asele F.A., Saravia F., Pardo G., Nita G.E., Gallo G., Luglio G., Tessera G., Abdelazim G., Shimy G., Barnabas G.N., Samson G., Irwin G., El Ashal G., El Sayed G.S., Tawfik G., Humm G., Balducci G., Sila G.C.M., Ihediwa G., Sila G.M., Azzie G., Camilleri G.M., Gemenetzis G., Gkiokas G., Karabelias G., Kyrou G., Tzikos G., Perrotta G., Teufelberger G., Ahlonsou G., Minguez G., Maharaj G., Galiqi G., Elhoseny G., Nagy G.S., Al Saied G., Shamsi G.S., Nastri G., Pata G., Cocorullo G., Curletti G., Pagano G., Pellino G., Confalonieri G., Gravante G., Lauzikas G., Dawnay G., Simutis G., Vasquez G., Landolfo G., Lazzari G., Lamanna G.L., Pascale G., Pesenti G., Sgroi G., Devadasar G.H., Moreira G., Borda-Luque G., Clerico G., Rotunno G., Salamone G., Sammarco G., Lap G., Padmore G., Tugnoli G., Kouraklis G., McLachlan G., Wood G., Ziubryte G., Podevin G., Rosenberg G.S., Yong G.L., Mannu G.S., Banipal G.S., Vega G.M.M., Miguel G.P.S., Fraga G.P., Recinos G., Servin G.R.P., Shiwani H.A., Al-Farram H., Hakim H., Zidan H., Amin H.A.A., Abdulaziz H., El-Badawy H.A., Elwakil H., Tolba H., Elabdin H.Z., Hajeh H., Ahmed H., Saad H., Aliyu H., Ebdewi H., Asumah H., Waleed H., Saad H.A., Youssef H., Natalie H., Royson H., Anderson-Knight H., Burns H., Thomas H.S., Pahlsson H.-I., Lakshmi H.N., Jordan H., Ibraheem H.I., Al-Hameedi H.I.I., Arsyad H.M., Dharamshi H.A., Mostafa H.A., El-Sheemy H., Tahboub H., Kretzmann H., Rashwan H., Abudeeb H., Khaled H., Nurqistan H.D., Bougard H., Baraka H., Gamal H., Shaker H., Miyasato H.S., Mohan H., Woodward H., Franco H., Francois-Coridon H., Lohse H.A.S., Shakshouk H.A.G., Kandil H., Mahmoud H., Kotobi H., Mendel H., Nnaj H., Karismaningtyas H., Cruz H., Magdy H., Bakry H.M., Heng H.E., Thorarinsdottir H., Safa H., Samih H., Mircea H., Sar H.K., Wong H.Y., Chong H.-Y., Kordorwu H.E.K., Glover-Addy H., Decoud H.P., Salem H.K., Dawoud H., Elfeki H., Emadeldin H., Bachri H., Shiwani H., Ali H., El-Kashef H., Mohammed H., Papaskarlatos I.-A., Abdelmotaleb I., AbdelFattah I., Alhabli I., Al-Slaibi I., AlYoussef I., Elzayat I., Elzayyat I., Alomar I.N., Rakha I., Raza I., Bjorklund I., Vasquez I., Rakita I., Hassan I., Adawi I., Njokanma I., Elkadsh I., Iannone I., Havemann I., Kyriazanos I., Patoulias I., Valioulis I., Dan I., Negoi I., Diaconescu I.-B., Montes I., Ortega-Vazquez I., Amole I., Bertuello I., Hanley I., Bsisu I., El Sayed I.M., Alvarez I.I.Z., Lawani I., Al-Azraqi I.A.A., Adel I., Awad I., Qawasmi I., Restrepo I.M., Fitzgerald J.E., Almy J., Sheehan J., Botero J.A.M., Herrera-Matta J., Restrepo J., Mihanovic J., Adeniran J., Brown J., Giles J., Glasbey J., Olivier J., Pape J., Richards J., Wheeler J., Yang J., Shah J., Pagnozzi J., Salcedo J., Amin J., Pastora J., Rosales J., Coronel J., Breaud J., De La Croix Allen Ingabire J., Marret J.-B., Colombani J.-F., Lecompte J.-F., Dalli J., Youssif J.H., Meqbil J., Onimowo J., Cornick J., Jeyakumar J., Nowers J., Rickard J., Skehan J., Makama J., Ting J.R.S., Tan J.J., Stuva J.P.G., Roth J., Luiz J.S., Law J.H., Siaw J.Y., Saw J.E., Abbasy J., Song J., Quezada J.H.J., Amoako J., Wiborg J., Swann J., Carreira J.-A., Edwards J., Vincent J., Tan J.K., Clegg-Lamptey J.-N., Joosten J., Nyberg J., Schultz J.K., Larsen J.W., Bondin J., Camilleri-Brennan J.F., Mora J.J.V., Allen J.L.Y., Whitaker J., Gribauskaite J., Soreide J.A., Narvestad J.K., Ajah J., Dakubo J., Heath J., Wild J.R.L., Setiawan J., Bravo J.A.C., Cardozo J.T., Aguilar-Jimenez J., Garcia-Marin J.A., Chiong J.A.C., Costa-Maia J., Hamasaki J., Hamaguchi J.L.H., Rodicio J.L., Celis J.M.V., Azmitia J.R.A., Ye J., Awuku-Asabre J., Psaila J., Luck J., Clements J.M., Razzaque J., Correa J.C., Carpio J., Gouws J., Matta J.J.H., Carmona J.M., Delgado J.M., Kabba J., Al-Faifi J.J., Vianna J.G.P., Camilleri-Brennan J., Menegussi J., Leroux J., Rod J., Hascoet J., Jimenez J., Oh J., Kutkevicius J., Kuliavas J., Zilinskas J., Lam J.C.Y., Lando J., Li K.H.G., Leung K.W., Lee K.Y., Kabongo K., Pinnagoda K., Hewage K., Kinandu K., Bhopal K.F., Palayan K., Dabbour K., Elshaer K., Bailey K., Hilal K., Bonavia K., Lagunavicius K., Varkalys K., Cross K., Chang K.Y.-C., Reinisch K.B., Whitehurst K., Gash K., Chu K., Lee K., Connor K., Gudlaugsdottir K., Das K., Atobatele K., Janardha K.C., Koay K.L., Poh K.-S., Clement K.D., Sammut K., Tan K.S.K., Aaniana K., Johnson K., Mealy K., Thorsen K., Espinoza K.T., Pluke K., Strupas K., Conlon K.C., Abozeid K., Alhady K., Aljboor K., Dawood K., Elbisomy K.H., Ibrahim K., Khattab K., El Deen K.N., Mahmud K., Qurie K., El-Dien K.S., Bassit K.A., Boukhal K., Ashour K., Lasheen K.T., Abdelbadeai K., Khan K., Syibrah K.Z., Atkinson K., Li K.K.K., Lafferty K., Soreide K., Augestad K.M., Konstantina K., Farmakis K., Gasteratos K., Maceviciute K., Keke K.R., Zamarin K., Styles K., Jasaitis K., Jokubonis K., Cassar K., Chung K.J., Gunaseelan K., Lee K.C., Carabott K., Agbedinu K., Boakye-Yiadom K., Maison K., Asare-Bediako K., Kusi K., Aung K.P., Szeto K.J.-Y., Psarianos K., Uscinas L., Arachchige L.A.J.J., Abusalem L., Lopez L.I.P., Joel L.W.L., Gavagna L., Koskenvuo L., Lorenzon L., Luque L., Fourcade L., Abdullahi L., Ismail L., Khulu L.B., Rodriguez L.-A.M., Yeo L.S., Israelsson L., Bray L.D., Pena L., Licari L., Solaini L., Yeang L.J., Henderson L., Richardson L., Roodt L., Reza L., Urbanavicius L., Venclauskas L., Barrientos L.A.M., Andersson L., Wilson L., Nymo L., Mauro L., Muntean L.I., Muntean L., Jeremic L., Anyanwu L.-J., Ahmed L.A.M., Fuentes-Rivera L., Rodriguez L., Garcia L.S., Sproule L., Eldamaty L., Jamal L., Da Silva L.A., Sabeeh L., Samison L.H., Ansaloni L., Bortolasi L., Turati L., Duinhouwer L., Vida L.C., Fievet L., Selvaggi L., Solis L.A.Z., Chew L.S., Bonavina L., Bucci L., Cloro L.M., Laufer L.A.V., Barneo L., Florez L.J.G., Helguero-Santin L.M., Barreda L.M.A., Tale L., Giavarini L., De Castro Segundo L.C.B., Tatagiba L.S., Eisner L., Mata L.P.S., Vermaas M., Amoako-Boateng M., Dziak M.W., Jha M., Gimzewska M., Gran M., O'neill M., Mitroudi M., Boijsen M., Al-Faqawi M., Elmasry M., Hamad M.G.M., Nasr M., Tata M.D., Essam M., Farahat M.M., Elnajjar M.A., Abdelshafy M., Abdelshakour M., Abdulgawad M., Abozyed M.A.F., Alrahawy M., Amreia M., Badawy M., Eldafrawy M., Elfiky M., Maher M.E., Elkhadrawi M., Moghazy M.E., Gomah M., Saad M.M., Metwally M.M., Morsi M., Saad M., Saami M., Salama M., Salma M., Shalaby M., Warda M., Zakaria M., Yuksek M.A., Javaid M., Estee M.M., Ebidy M., Ebidy M.M., Careta M.C., Marcus M., Dabboor M., Aboelella M., Dayie M., Elsayed M., Falzon M., Hassan M., Sund M., Leung M.F., Yeung M.H.A., Abd-Elmawla M., Saeed M., Drungilas M., Jokubauskas M., Vilcinskas M., Roxas M.F., Hache-Marliere M., Lopez M., Castro M.R., Mendez M., Dar M., Abu-Toyour M., Salah M., Higgins Roche M.O., Catani M., Pascale M.M., Migliore M., De Leon M.Z.P., O'Shea M., Montrimaite M., Notarnicola M., Hussain M., Arango M.C.M., Grella M.G., Hjertberg M., Lanau M.I.V., Mano M.J.B., Aguilera M.L., Modolo M.M., Mayasari M., Ringressi M.N., Montejo M.S.G., Merlo M.S., Utter M., Valcarcel-Saldana M., Aguilera-Arevalo M.-L., Darweesh M., Gad M.O., Aboul-Naga M.S., Giglio M.C., Malavenda M., Lapitan M.C., Parreno-Sacdalan M.D., Paul M., Renaux-Petel M., Agius M., Del Carmen Escalante Salas M., Dickfos M., Pimenta M.L., Urquizu M.C., Corbellino M., Jacobe M., Pasini M., Trompetto M., Leal M., Manriquez-Reyes M., Popa M., Hampton M.I., Sykes M., Wagener M., Zuber M., Bliksoen M., Glynn M., Jarmin M., Kyereh M., Perino M., Shawky M.Y., Vella-Baldacchino M., Vargas M., Altarayra M., Elashmawy M., Elshobary M., Hamdan M., Sayed M., Abubakr M., Fahim M., Shawki M., Khan M.A., Shubianok M., Al-Mousa M., Alghamdi M., Jawaid M., Machaca M., Dal Canto M., Coletti M., Pazuskis M., Bratu M., Bratu M.R., Rubinkiewicz M., Papandrea M., Ripa M., Ekow M., 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P., Mingrone P., Yoganathan P., Major P., Francois P., Ignatavicius P., Mazrimas P., Arachchi P.P., Jain P., Kwakyeafriyie P., Har P.A.L., Chin P.X., Malik P., Nashidengo P., Liu Q., Alimi Q., Ballouhey Q., Ellison Q., Tze R.G.E., King R., Moore R., Amandito R., Dorani R.M.N.R., Araujo R., Soley R., Roszkowski R., Galleano R., Narayanan R., Herikstad R., Kamil R., Satoskar R., Kabariti R., Staerkle R.F., Nataraja R., Oumer R., Shaker R., Jonnalagadda R., Jaramillo R.A., Cardozo R.A.M., Mamdouh R., Saadeh R., Rodriguez-Uria R., Claire R., Abdelhamed R., Bratu R.-M., Zilinskiene R., Bennai R.M., Alyahya R., Fakher R., Husseiny R., Khreishi R., Balila R.M.H., Elashry R., El-Din R.A., Alshareef R., Saad R., Melo R., D'cruz R., Rajan R., Karim R., Velasquez R., Gilbert R., Lilford R., Opoku-Agyeman R., Spence R., Gilbert R.W., Hagan R., Alyami R., Ots R., Rakauskas R., Khan R., George R., Karlo R., Kerley R., McIntyre R., Morton R., Parker R., Tyler R., Bugeja R., Tutino R., Villa R., 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Elhadry S., Hussein S., Mahmoud S., Talukder S., Shaharuddin S., El-Din S.A., Aql S., Torres S.G., Aliyu S., Karandikar S., Koh S., Mohamed S.R., Elsheikh S., Shehata S., Tariq S., Gamal S., Elkholy S.S., Gaafar S., Tewari S., Dindyal S., Tharmalingam S., El Mesery S., Ymeri S., Nadkarni S., Ayyar S., Kong S.N., Teo S.Y., Gokani S., Lim S.Y., Holte S., Basilico S., Boni S., De Franciscis S., Gosling S.G., Gosling S., Ng S., Stock S., Juciute S., Kasputyte S., Conci S., Sandler S., Targa S., Yam S.Y., Asilah S.M.D., Kamarulzamil S.N.A., Sivaganesh S., Suleiman S.I., Chung S., Elsobky S., Mouttalib S., Abushamleh S., Elmihy S., Ahmed S.M., Turkustani S., Hmila S., Africa S., Pai S., Bhat S., Prasad S.S., Paul S., Parasyris S., Botes S., Breitenstein S., Zammit S., Berti S., Cucumazzo S., Basso S.M.M., Roncali S., Kim S.B., Saar S., Kwok S.H.-W., Van Straten S., Dias S., Chapman S.J., Kache S., McAleer S., Knight S.R., Tabiri S., Petrikenas S., Fergusson S.J., Parpoudi S., Germanos S., 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Chan X.W., Neo Y.T., Souaibou Y.I., Ukwenya Y., Salama Y., Rajjoub Y., Ibrahim Y., Abd-Elrasoul Y., Elfouly Y., Hegazy Y., Soliman Y., El Salam Y.A., Tan Y.W., Zakaria Y., Reddy Y., Tan Y.K., Mok Y.T., Cheong Y.J., Gan Y.Y., Der Y., Mogan Y.P., Allam Y., Asar Y.H., Tew Y.Y., Abuowda Y., Shoura Y.E., Bermudez Y.E.A., Cengiz Y., Cheung Y.H.E., Altinel Y., Ng Y.K., Macchitella Y., Aigrain Y., Mikwar Z., Jaffry Z., Khan Z.A., Iftikhar Z., Elsayed Z.M., Zhang Z., Sam Z.H., Urniezius Z., Dambrauskas Z., Bentounsi Z., and Tverskis Z.
Subjects: surgical unmetneed, no keywords listed, appendicitis, global surgery, Financial Stress, Health Care Costs, Appendicitis, Financial Stre, Health Care Cost, Cost of Illness, Humans, appendicitis,economic burden, surgery, Surgery, Appendiciti, Human
Abstract: Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and $73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and $75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially.
Published: 2022

29. Laparoscopic One Anastomosis Gastric Bypass Versus Laparoscopic One Anastomosis Gastric Bypass with Braun Anastomosis: What's Better?

Author: Francesca Ciccarese, Giovanni Cesana, Alberto Oldani, Roberta Villa, Stefano Olmi, Riccardo Giorgi, Stefano Maria De Carli, Matteo Uccelli, Adelinda Angela Giulia Zanoni, Giulia David, Olmi, S., Oldani, A., Cesana, G., Ciccarese, F., Uccelli, M., De Carli, S. M., Villa, R., David, G., Giorgi, R., and Zanoni, A. A. G.
Subjects: Adult, Male, medicine.medical_specialty, bariatric surgery, Gastric Bypass, Context (language use), Anastomosis, Braun anastomosis, Bile reflux, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Gastrectomy, Weight Loss, medicine, Esophagitis, Humans, Retrospective Studies, business.industry, Reflux, GERD, Perioperative, Middle Aged, Esophageal cancer, medicine.disease, digestive system diseases, Obesity, Morbid, Surgery, Jejunum, 030220 oncology & carcinogenesis, Gastroesophageal Reflux, Female, Laparoscopy, 030211 gastroenterology & hepatology, business
Abstract: Background and Aims: Although laparoscopic one anastomosis gastric bypass (LOAGB) is a promising bariatric procedure, a large number of surgeons have strong objections mainly because of risk of bile reflux, marginal ulceration, malnutrition, and long-term risk of gastric and esophageal cancer. Lateral enteroenterostomy placed distally to a gastrojejunal anastomosis shows efficacy in preventing bile reflux after gastric resection and gastrojejunal anastomosis, but at present its efficacy in a bariatric surgery context has not been evaluated. Patients and Methods: From January 2013 to December 2018, 100 patients have been admitted to our department to be treated by performing LOAGB. Patients have been divided into two groups on the basis of the indications to this surgical procedure; Group A: presence of de novo gastroesophageal reflux disease (GERD) or severe esophagitis after laparoscopic sleeve gastrectomy, with or without weight regain; Group B: LOAGB as primary procedure. Another group of 30 patients (Group C) underwent LOAGB with Braun anastomosis as primary bariatric surgical procedure for morbid obesity. We have conducted a retrospective analysis of the surgical outcomes in terms of perioperative mortality, short-, mid-, and long-term postoperative complications and weight loss. Results: Group A: 50 patients; incidence of postoperative GERD, esophagitis, or esophageal ulcers was 26% (13 cases). All these patients have been successfully treated by performing Braun anastomosis. Group B: 20 patients; incidence of de novo reflux was 25% (5 cases); Braun anastomosis was performed with complete resolution of signs and symptoms in all cases. Group C: 30 patients; no cases of de novo reflux, esophagitis, or anastomotic ulcers occurred. Conclusion: Braun anastomosis seems to be a useful surgical tool to prevent the onset of de novo reflux, esophagitis, and anastomotic ulcers.
Published: 2019
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30. Surgical Outcomes of Rectal Resection: Our 10 Years Experience

Author: Giovanni Cesana, Stefano Olmi, Riccardo Giorgi, Matteo Uccelli, Roberta Villa, Francesca Ciccarese, Alberto Oldani, Stefano Maria De Carli, Oldani, A., Cesana, G., Uccelli, M., Ciccarese, F., Giorgi, R., De Carli, S. M., Villa, R., and Olmi, S.
Subjects: Adult, Male, Laparoscopic surgery, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Fistula, laparoscopy, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, rectal surgery, medicine, cancer, Humans, Laparoscopy, Aged, Retrospective Studies, Aged, 80 and over, Proctectomy, medicine.diagnostic_test, Rectal Neoplasms, business.industry, Mortality rate, Cancer, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Amputation, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Complication, business, Follow-Up Studies
Abstract: Background: Colorectal cancer, one of the most common tumor- and cancer-related deaths worldwide, requires a multidisciplinary management including neoadjuvant chemoradiotherapy and surgery. Laparoscopic surgery for rectal cancer is gaining popularity due to its safety profile and good oncological results, if performed by experienced surgeons in specialized centers. This study describes our 10 years experience in minimally invasive rectal cancer surgery. Methods: We have retrospectively evaluated a series of 140 patients treated with laparoscopic approach for rectal malignant and benign diseases. Results: A total of 134 patients (95.7%) underwent anterior rectal resection, in the remaining 6 cases (4.3%) abdominoperineal amputation was performed. All but 13 cases have been treated with laparoscopic approach, with conversion rate of 5.7%. Postoperative morbidity rate was 8.6% (2 cases of peritoneal bleeding and 10 cases of anastomotic fistulae; in 2 cases, fistula occurred in patients previously treated with chemoradiation). Conclusions: Conventional laparoscopy can provide adequate oncological outcomes even in patients with advanced rectal cancer, with advantages in terms of postoperative hospital stay, recovery time, acceptable operative time, and low complication and conversion rates.
Published: 2019
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31. D4.4: Recommendations on Policies and Incentives for Quality Science Communication

Author: Matteo Di Rosa, Claudia Iasillo, Ilda Mannino, Alessandra Fornetti, Enrico Costa, Roberta Villa, Fabiana Zollo, Laura Bell, Margot Bezzi, Suzanne Franks, Jacopo Pasotti, and Joseph Roche
Subjects: science communication, policy raccomendation
Abstract: This deliverable relates to the QUEST Task 4.3 “Recommendations on Policies and Incentives for Quality Science Communication”. The task aims to identify recommendations to create the framework conditions for incentivising quality communication of science and R&I to a wide public for scientists and research institutions, as well as across different media and communicators, focusing in particular on the QUEST research strands, i.e. journalism, museums, and social media. Also, actions focusing on public engagement are considered. The recommendations have been developed by combining desk research with the results of research conducted within the QUEST project, based on codesign activities engaging representatives of the target groups that might foster the promotion of policy and incentives at different levels (i.e. journalists, journalists, museums, scientists, communicators, policymakers, media industry, social media platforms, governance of research institutions from the public and the private sector, etc.). In particular, the document investigates: the role of policy, at institutional, national and EU level, to increase quality in science communication, what strategies policy-makers can introduce to limit the growing spread of disinformation among citizens in favour of an increasing distrust towards public bodies, what specific policies and incentives promoted by funding organizations can affect public engagement with science and technology. &nbsp
Published: 2021
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32. Neuroimaging appearance of hypothalamic hamartomas in monozygotic twins with Pallister-Hall syndrome: case report and review of the literature

Author: Alessandra Consales, Giulia Ardemani, Claudia Maria Cinnante, Mariana Rita Catalano, Claudia Giavoli, Roberta Villa, Maria Iascone, Camilla Fontana, Maria Francesca Bedeschi, and Monica Fumagalli
Subjects: Settore MED/38 - Pediatria Generale e Specialistica, brain MRI, Hypothalamic hamartoma, Hamartoma, Pallister-Hall Syndrome, Twins, Infant, Newborn, Pallister-Hall syndrome, cerebral ultrasound, Humans, Neuroimaging, Twins, Monozygotic, Hypothalamic Diseases, Infant, General Medicine, Newborn, Monozygotic, Neurology (clinical)
Abstract: Background Pallister-Hall syndrome (OMIM #146510) is a rare autosomal dominant condition caused by a mutation in the GLI3 gene. The cardinal feature of Pallister-Hall syndrome is the presence of hypothalamic hamartomas, which may manifest with seizures, panhypopituitarism and visual impairment. In Pallister-Hall syndrome, dysplastic histogenetic processes responsible for hypothalamic hamartomas are thought to disrupt early craniofacial development. The clinical presentation of Pallister-Hall syndrome may include: characteristic facies (low-set and posteriorly angulated ears, short nose with flat nasal bridge), cleft palate and uvula, bifid epiglottis and laryngotracheal cleft, limb anomalies (e.g., polysyndactyly, short limbs and nail dysplasia), anal atresia, genitourinary abnormalities and congenital heart defects. Case presentation We report the case of two monochorionic diamniotic twins diagnosed with Pallister-Hall syndrome during the neonatal period, after the identification of a hypothalamic hamartoma on day 1 by cerebral ultrasound scan, later confirmed by brain magnetic resonance imaging. Cerebral ultrasound and magnetic resonance imaging presentations were identical in both twins. Discussion and conclusions We review previously published cases (four reports) of hypothalamic hamartomas identified via cerebral ultrasound and compare reported ultrasonographic features. Main differential diagnoses based on cerebral ultrasound findings are discussed. Full description of typical magnetic resonance imaging appearance is also provided. This is the first case reported in the literature of monochorionic diamniotic twins affected by genetically confirmed Pallister-Hall syndrome with identical hypothalamic hamartomas at cerebral ultrasound and magnetic resonance imaging. Moreover, this paper adds to the existing literature on the sonographic appearance of hypothalamic hamartomas. Considering the consistency in hypothalamic hamartomas’ sonographic appearance, we support the use of cerebral ultrasound as a first-line neuroimaging modality in case of clinical suspicion of Pallister-Hall syndrome. Graphical Abstract
Published: 2021

33. Laparoscopic transperitoneal hernia repair (TAPP) in emergency: long-term follow-up in a high volume centre

Author: Riccardo Giorgi, M. Bonaldi, Matteo Uccelli, D. Ferrari, Ayman Ismail, A. Delcarro, Giovanni Cesana, Adelinda Angela Giulia Zanoni, Roberta Villa, Francesca Ciccarese, Alberto Oldani, S. Olmi, Carolina Rubicondo, S. De Carli, Zanoni, A. A. G., Delcarro, A., Ciccarese, F., Villa, R., Oldani, A., Giorgi, R., Rubicondo, C., Bonaldi, M., Cesana, G., Uccelli, M., De Carli, S., Ismail, A., Ferrari, D., and Olmi, S.
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Pain, Hernia, Inguinal, TAPP repair, Young Adult, Incarcerated and strangulated inguinal hernias, medicine, Humans, Hernia, Laparoscopy, Herniorrhaphy, Aged, Retrospective Studies, Aged, 80 and over, Groin, medicine.diagnostic_test, business.industry, Postoperative complication, Perioperative, Bowel resection, Middle Aged, Surgical Mesh, medicine.disease, Hernia repair, Surgery, medicine.anatomical_structure, Treatment Outcome, Seroma, Emergency, Female, business, Follow-Up Studies
Abstract: Purpose: Aim of this study was to analyse feasibility, safety and effectiveness of laparoscopic transperitoneal hernia repair (TAPP) approach to inguinal hernias in the emergency setting, with a longer follow-up than the studies present in literature. Methods: We retrospectively analysed all patients who underwent emergency TAPP hernia repair in San Marco Hospital (Zingonia, Italy), from September 2010 to June 2020. A prospectively collected database of 685 consecutive TAPP hernia repair was reviewed. Feasibility and safety were evaluated through operative time, conversion rate, perioperative mortality, morbidity and prosthesis infection rate. Effectiveness was assessed by recurrence and complication rate, acute (during admission) and chronic (during follow-up) pain by Visual Analogic Scale (VAS), and recovery to normal activity in a long-term follow-up (mean period 1718days). Results: The final study group included 47 patients. The mean age was 59.6years (range 22–89), 29 patients were male and 18 were female. The mean operation time was 64min. Two cases were converted to open approach (4%). In four cases bowel resection became necessary (8.5%). Appendicectomy and omentectomy occurred once and twice, respectively (2% and 4%), and orchiectomy was required in two patients (4%). Seroma was the only postoperative complication that we registered in four patients.During a mean follow-up period of 1718days, there was no recurrence of the hernia or other complications. Five patients referred mild occasional groin pain (VAS < 3), with quick relief without taking any pain killers. Conclusion: TAPP approach is a safe, feasible and effective therapeutic option for groin hernias in emergency setting. No recurrence or severe complications were reported in over 4years of follow-up.
Published: 2021

34. Quality indicators for science communication: results from a collaborative concept mapping exercise

Author: Roberta Villa, Arko Olesk, Suzanne Franks, Ana Lucia Schmidt, Alessandra Fornetti, Joseph Roche, Berit Renser, Laura Bell, Barbara Schofield, Fabiana Zollo, and Ilda Mannino
Subjects: Knowledge management, Settore INF/01 - Informatica, Computer science, Concept map, business.industry, Communication, media_common.quotation_subject, 05 social sciences, Stakeholder, 050905 science studies, Rigour, Style (sociolinguistics), Settore SPS/08 - Sociologia dei Processi Culturali e Comunicativi, Presentation, Trustworthiness, 0502 economics and business, Science communication, Quality (business), 0509 other social sciences, business, 050212 sport, leisure & tourism, media_common
Abstract: Although the need to improve quality of science communication is often mentioned in public discussions, the science communication literature offers few conceptualizations of quality. We used a concept mapping approach, involving representatives of various science communication stakeholder groups working collaboratively, to propose a framework of quality. The framework organizes individual elements of quality into twelve indicators arranged into three dimensions: trustworthiness and scientific rigour, presentation and style, and connection with society. The framework supports science communicators in reflecting on their current practices and designing new activities, potentially improving communication effectiveness.
Published: 2021

35. COVID-19 and Obesity: Is Bariatric Surgery Protective? Retrospective Analysis on 2145 Patients Undergone Bariatric-Metabolic Surgery from High Volume Center in Italy (Lombardy)

Author: Alberto Oldani, Matteo Uccelli, Francesca Ciccarese, Simone Targa, Giancarlo Cesana, Andrea D'Alessio, Stefano Maria De Carli, Roberta Villa, Adelinda Angela Giulia Zanoni, Stefano Olmi, Ayman Ismail, Lorenzo G. Mantovani, Riccardo Giorgi, Giovanni Cesana, Uccelli, M., Cesana, G. C., De Carli, S. M., Ciccarese, F., Oldani, A., Zanoni, A. A. G., Giorgi, R., Villa, R., Ismail, A., Targa, S., D'Alessio, A., Cesana, G., Mantovani, L., Olmi, S., Uccelli, M, Cesana, G, De Carli, S, Ciccarese, F, Oldani, A, Zanoni, A, Giorgi, R, Villa, R, Ismail, A, Targa, S, D'Alessio, A, Mantovani, L, and Olmi, S
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), Original Contributions, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Bariatric surgery, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, medicine, Humans, Obesity, Risk factor, Young adult, Laparoscopy, Aged, Retrospective Studies, Nutrition and Dietetics, medicine.diagnostic_test, SARS-CoV-2, business.industry, Incidence (epidemiology), COVID-19, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Hospitalization, Obesity surgery, Pneumonia, Italy, Female, 030211 gastroenterology & hepatology, Metabolic surgery, business
Abstract: Introduction On February 20, 2020, a severe case of pneumonia due to SARS-CoV-2 was diagnosed in northern Italy (Lombardy). Some studies have identified obesity as a risk factor for severe disease in patients with COVID-19. The purpose of this study was to investigate the incidence of SARS-CoV-2 infection and its severity in patients who have undergone bariatric surgery. Material and Methods During the lockdown period (until May 2020), we contacted operated patients by phone and social networks (e.g., Facebook) to maintain constant contact with them; in addition, we gave the patients a dedicated phone number at which to call us for emergencies. We produced telemedicine and educational videos for obese and bariatric patients, and we submitted a questionnaire to patients who had undergone bariatric surgery in the past. Results A total of 2145 patients (313 male; 1832 female) replied to the questionnaire. Mean presurgical BMI: 44.5 ± 6.8 kg/m2. Mean age: 44.0 ± 10.0 year. Mean BMI after surgery: 29.3 ± 5.5 kg/m2 (p
Published: 2021

36. Exon-Trapping Assay Improves Clinical Interpretation of

Author: Lucia, Micale, Silvia, Morlino, Annalisa, Schirizzi, Emanuele, Agolini, Grazia, Nardella, Carmela, Fusco, Stefano, Castellana, Vito, Guarnieri, Roberta, Villa, Maria Francesca, Bedeschi, Paola, Grammatico, Antonio, Novelli, and Marco, Castori
Subjects: Adult, Male, COL11A2, Developmental Disabilities, RNA Splicing, Dwarfism, Collagen Type XI, Osteochondrodysplasias, Vitreous Detachment, Protein Structure, Secondary, Article, stickler syndrome, COL11A1, Diagnosis, Differential, Humans, Point Mutation, Protein Isoforms, RNA, Messenger, Connective Tissue Diseases, Base Sequence, Infant, Newborn, High-Throughput Nucleotide Sequencing, Infant, Introns, Ehlers-Danlos Syndrome, Female
Abstract: Stickler syndrome (SS) is a hereditary connective tissue disorder affecting bones, eyes, and hearing. Type 2 SS and the SS variant otospondylomegaepiphyseal dysplasia (OSMED) are caused by deleterious variants in COL11A1 and COL11A2, respectively. In both genes, available database information indicates a high rate of potentially deleterious intronic variants, but published evidence of their biological effect is usually insufficient for a definite clinical interpretation. We report four previously unpublished intronic variants in COL11A1 (c.2241 + 5G>T, c.2809 − 2A>G, c.3168 + 5G>C) and COL11A2 (c.4392 + 1G>A) identified in type 2 SS/OSMED individuals. The pathogenic effect of these variants was first predicted in silico and then investigated by an exon-trapping assay. We demonstrated that all variants can induce exon in-frame deletions, which lead to the synthesis of shorter collagen XI α1 or 2 chains. Lacking residues are located in the α-triple helical region, which has a crucial role in regulating collagen fibrillogenesis. In conclusion, this study suggests that these alternative COL11A1 and COL11A2 transcripts might result in aberrant triple helix collagen. Our approach may help to improve the diagnostic molecular pathway of COL11-related disorders.
Published: 2020

37. Clinical Evaluation of a Topical Formulation for the Management of Onychomycosis

Author: Daniele, Maggioni, Annamaria, Cimicata, Antonella, Praticò, Roberta, Villa, Ferdinando, Bianchi, Silvia Busoli, Badiale, Umberto, Piana, and Claudio, Angelinetta
Subjects: integumentary system, Original Research
Abstract: BACKGROUND: Onychomycosis is a diffused fungal-associated disease affecting the nails. It induces discoloration, dystrophy, and, in the most severe cases, nail detachment. No completely effective pharmacological cures are available for onychomycosis. Available treatment options usually require a long-term treatment period and might raise safety concerns. OBJECTIVE: The aim of this preliminary clinical study is to evaluate the efficacy of Myco Clear® (MC) in improving the structural integrity and appearance of nails affected by mild onychomycosis. MC is a topical product to be applied on the nails either for onychomycosis treatment or for the prevention of fungal nail infections. Its main action is the formation of a mechanic protective barrier on the nail surface, which protects the damaged nail structure from additional external aggressions and prevents further pathogen penetration. METHODS: This monocentric, single-arm investigation enrolled 30 subjects with damaged nails on the feet. Patients were asked to apply the product once a day for 56 consecutive days; the instrumental analysis of nail roughness was obtained after seven, 14, 28, and 56 days of product application. In addition, the clinical evaluation of nail integrity and hardness were performed at baseline and after seven, 14, 28 and 56 days. RESULTS: The obtained data were statistically evaluated in comparison to baseline. MC treatment significantly promoted a restoration of the nail structure and an improvement in its appearance; furthermore, no adverse events were reported, thus demonstrating that MC is optimally tolerated. CONCLUSION: The results of this pilot study suggest that MC is effective in improving the overall appearance and structural integrity of damaged nails affected by possible mild onychomycosis.
Published: 2020

38. Author response for 'An additional piece in the TBX6 gene dosage model: A novel nonsense variant in a fetus with severe spondylocostal dysostosis'

Author: Roberta Villa, Maria Francesca Bedeschi, Angela Iasci, Alessia Arossa, Benedetta Ischia, Edoardo Errichiello, Tommaso Rizzuti, Maria Angela Pavesi, and Orsetta Zuffardi
Subjects: Genetics, Fetus, business.industry, media_common.quotation_subject, TBX6, Nonsense, Medicine, business, medicine.disease, Gene dosage, Spondylocostal dysostosis, media_common
Published: 2020
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39. An additional piece in the TBX6 gene dosage model: A novel nonsense variant in a fetus with severe spondylocostal dysostosis

Author: Maria Angela Pavesi, Tommaso Rizzuti, Roberta Villa, Edoardo Errichiello, Alessia Arossa, Orsetta Zuffardi, Maria Francesca Bedeschi, Angela Iasci, and Benedetta Ischia
Subjects: Hernia, Diaphragmatic, Male, Fetus, business.industry, TBX6, media_common.quotation_subject, Nonsense, Gene Dosage, medicine.disease, Bioinformatics, Gene dosage, Severity of Illness Index, Spondylocostal dysostosis, Aborted Fetus, Genetics, medicine, Humans, Abnormalities, Multiple, Female, Genetic Predisposition to Disease, business, T-Box Domain Proteins, Genetics (clinical), media_common
Published: 2020

40. Ultrasound 2-D and 3-D diagnosis of Rubinstein-Taybi syndrome in a 21-week-old fetus

Author: Stefano De Marinis, Chiara Maria Soldavini, Enrico Ferrazzi, Francesco D'Ambrosi, Giulia Emily Cetera, Roberta Villa, and Luisa Ronzoni
Subjects: 0301 basic medicine, Pediatrics, medicine.medical_specialty, Prenatal diagnosis, Case Report, 030105 genetics & heredity, Ultrasonographic examination, 03 medical and health sciences, Fetus, Pregnancy, Prenatal Diagnosis, Internal Medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Rubinstein-Taybi Syndrome, Rubinstein–Taybi syndrome, business.industry, Ultrasound, Gestational age, General Medicine, medicine.disease, 030104 developmental biology, In utero, Female, business, Ductus venosus
Abstract: Rubinstein–Taybi syndrome is a rare genetic multisystem disorder with an estimated prevalence between 1 per 100,000–125,000 live births. Diagnosis is usually clinical and subsequent to birth. In fact, the rarity of the syndrome and the presence of aspecific morphologic anomalies make prenatal diagnosis challenging. The aim of our work is to analyze ultrasonographic findings, detectable with a combination of 2D and 3D techniques, which may increase the sensitivity of in utero diagnosis of this condition. We report a case of a sonographic prenatal diagnosis of broad and angulated thumbs and halluces and of an abnormal ductus venosus at 21 weeks of gestational age. These findings allowed us to suspect Rubinstein–Taybi syndrome. An accurate ultrasonographic examination may allow a prenatal diagnosis of those syndromes which are usually diagnosed after birth.
Published: 2020

41. A case series of CHARGE syndrome: identification of key features for a neonatal diagnosis

Author: Fabio Triulzi, Elisa Scola, Paola Francesca Ajmone, Martina Buscemi, Viola Giulia Carlina Fergnani, Fabio Mosca, Silvana Gangi, Lorenzo Colombo, Roberta Villa, Claudia Cinnante, Odoardo Picciolini, Beatrice Letizia Crippa, Maria Francesca Bedeschi, and Cesare Rossi
Subjects: 0301 basic medicine, Male, Pediatrics, medicine.medical_specialty, Primary care, 030105 genetics & heredity, Diagnosis, Differential, 03 medical and health sciences, CHARGE syndrome, Temporal bone, medicine, Humans, Retrospective Studies, business.industry, Maternal and child health, Medical record, Research, lcsh:RJ1-570, Infant, Newborn, lcsh:Pediatrics, medicine.disease, Key features, Ear malformations, 030104 developmental biology, Early Diagnosis, Italy, Clinical diagnosis, Female, business
Abstract: Background An early diagnosis of CHARGE syndrome is challenging, especially for the primary care physicians who often take care of neonates with multiple congenital anomalies. Here we report eight cases of CHARGE syndrome whose diagnosis was made early in life with the intent to identify the most helpful features allowing a prompt clinical diagnosis. Methods Medical records of patients with CHARGE syndrome whose diagnosis was made at the Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico in Milan, Italy were retrospectively reviewed. Results Taken together, these patients reflect the considerable phenotypic variability of the syndrome; in one patient, the diagnosis was made immediately after birth because all the major criteria were met. In six patients, presenting with relatively nonspecific defects, a temporal bone computerized tomography scan was essential to achieve the correct diagnosis. In one patient, the diagnosis was made later than the others were. A careful examination revealed the presence of outer, middle, and inner ear anomalies: these elements, in the absence of any additional major criteria, represented for us an important diagnostic clue. Conclusions This article suggests that an accurate evaluation of the ear should be made every time CHARGE syndrome is considered as a likely diagnosis even when the standard criteria are not fulfilled.
Published: 2020

42. Laparoscopic Surgery of Gastric Cancer with D2 Lymphadenectomy and Omentum Preservation: Our 10 Years Experience

Author: Alberto Oldani, Adelinda Angela Giulia Zanoni, Carolina Rubicondo, Stefano Olmi, Ayman Ismail, Matteo Uccelli, Giovanni Cesana, Riccardo Giorgi, Roberta Villa, Francesca Ciccarese, Stefano Maria De Carli, Olmi, S., Uccelli, M., Oldani, A., Cesana, G., Ciccarese, F., Giorgi, R., Villa, R., De Carli, S. M., Zanoni, A. A. G., Rubicondo, C., and Ismail, A.
Subjects: Laparoscopic surgery, Adult, Male, medicine.medical_specialty, medicine.medical_treatment, laparoscopy, Gastrectomy, Stomach Neoplasms, medicine, Humans, omentum preservation, Laparoscopy, Aged, Retrospective Studies, Aged, 80 and over, D2 lymphadenectomy, medicine.diagnostic_test, business.industry, gastric cancer, Cancer, Retrospective cohort study, Middle Aged, medicine.disease, gastrectomy, humanities, Surgery, body regions, Treatment Outcome, lymphadenectomy, Lymph Node Excision, Lymphadenectomy, Female, business, Laparoscopic treatment, Omentum, Follow-Up Studies
Abstract: Introduction: The debate is still open about laparoscopic treatment of gastric cancer. The aim of this retrospective study is to analyze our short-, medium-, and long-term surgical and oncological results in laparoscopic treatment of gastric cancer with D2 lymphadenectomy and omentum preservation. Materials and Methods: From January 2010 to June 2018, after >150 surgical procedures for gastric cancer performed by minimally invasive approach, we performed 100 laparoscopic subtotal gastrectomies and 38 total gastrectomies, both for early gastric cancer (EGC) and advanced gastric cancer (AGC). We always made a D2 lymphadenectomy or higher. As often as possible, we performed omentum-preserving technique. Primary outcomes analyzed included incidence of medical and surgical complications. Secondary outcomes analyzed were survival probability and incidence of relapse. Every patient read and signed informed consent before surgery. Results: Mean operative time: 2.4 ± 0.7 hours (range 1.2-4.7 hours). Rate of conversions: 14.5% (20/138); intraoperative complications: 1.4% (2/138) and positive resection margins: 6.5% (9/138). Overall incidence of duodenal fistula: 3.6% (5/138). Rate of reoperation was 7.3% (10/138). Postoperative complications according to Clavien-Dindo classification: I 3.6% (5/138); II 13.0% (18/138); III 5.8% (8/138); III B 0.7% (1/138); V 1.4% (2/138). Overall survival with 60 months follow-up was 58%. Overall 60 months incidence of relapse was 44%. Patients with omentum preservation had a lower incidence of relapse than patients with omentectomy (40% versus 57% P =.002). Conclusions: Laparoscopic treatment of gastric cancer with D2 lymphadenectomy and omentum preservation is safe and feasible, both for EGC and for AGC. Although this study has limitations, omentum-preserving technique was associated with a statistically lower recurrence rate.
Published: 2020

43. Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness

Author: Henriette Roed Nielsen, Judith Balmaña, Anne-Marie Gerdes, Ellen Honisch, Melissa C. Southey, Ramunas Janavicius, Finn Cilius Nielsen, Douglas F. Easton, Linda Steele, Ava Kwong, Sung Won Kim, Bjarni A. Agnarsson, Piera Rizzolo, Angela R. Solano, Mads Thomassen, Johannes Lemke, Grazia Artioli, Heli Nevanlinna, Johanna I. Kiiski, Frans B. L. Hogervorst, Jong Won Lee, Diana Eccles, Mark H. Greene, Marc Tischkowitz, David E. Goldgar, Angela R. Bradbury, Javier Benitez, Marie Navratilova, Dominique Stoppa-Lyonnet, Arjen R. Mensenkamp, Alfons Meindl, Zisun Kim, Nadine Tung, Agnes Jager, Matthew L. Freedman, Ana Osorio, Norbert Arnold, Doris Steinemann, Inge Søkilde Pedersen, Patricia Llovet, Rob B. van der Luijt, Vivek L Patel, Munaza Ahmed, Lidia Moserle, Irene Konstantopoulou, Jackie Cook, Jacques Simard, Joan Brunet, Johanna Rantala, Kai-ren Ong, Carole Brewer, Joe Dennis, Sook-Yee Yoon, Hanne Meijers-Heijboer, Roberta Villa, Katie Snape, Louise Izatt, Ana Peixoto, Susan M. Domchek, Nina Ditsch, D. Gareth Evans, Tara M. Friebel, Sue K. Park, Katherine L. Nathanson, Lenka Foretova, Miguel Angel Pujana, Edith Olah, Hélène Schuster, Raymonda Varon-Mateeva, Silvia Tognazzo, Payal D. Shah, Oskar T. Johannsson, Hans Ehrencrona, Paul Gesta, Ian G. Campbell, Drakoulis Yannoukakos, Mirjam Larsen, Anthony V. D'Amico, Liene Nikitina-Zake, Davide Bondavalli, Valérie Bonadona, Paul A. James, Alan Donaldson, Antonis C. Antoniou, Bernd Auber, Andrew K. Godwin, Denise Molina Gomes, Jihyoun Lee, Laurence Faivre, Almuth Caliebe, Pilar Garre, Siddhartha Yadav, Julika Borde, Pedro Pérez-Segura, Birgitte Bertelsen, Paolo Peterlongo, Michael T. Parsons, John L. Hopper, Bruno Buecher, Goska Leslie, Shan Wang-Gohrke, Amanda B. Spurdle, T.M. Mooij, Juliane Ramser, kConFab Investigators, Lídia Feliubadaló, Susanne E. Boonen, Bernard Peissel, Anna von Wachenfeldt, Timothy R. Rebbeck, Christi J. van Asperen, Víctor Lorca, Estela Carrasco, Elisa Alducci, Ulrike Faust, Karin Kast, Gord Glendon, Saundra S. Buys, Fergus J. Couch, Mariarosaria Calvello, Istvan Bodrogi, Kathryn J. Ruddy, Philipp Wagner, Fabienne Lesueur, Evan L. Busch, Hebon Investigators, Laura Cortesi, Christian F. Singer, Ute Hamann, Giuseppe Damante, Stefania Tommasi, Esther M. John, Jacopo Azzollini, Cristina Zanzottera, Angelica M. Gutierrez-Barrera, Emmanuelle Mouret-Fourme, Claire Saule, Rosa B. Barkardottir, Kristin K. Zorn, Kerstin Rhiem, Uffe Birk Jensen, Mark Pomerantz, Yuan Chun Ding, Alison H. Trainer, Marco Montagna, Vijai Joseph, Domenico Palli, Kwang-Pil Ko, Angel M. Cronin, Susan L. Neuhausen, Dieter Niederacher, Laura Ottini, Angela Toss, Rita K. Schmutzler, Muriel Belotti, Jeffrey N. Weitzel, Caroline M. Seynaeve, Ileana Carnevali, Adalgeir Arason, Rosalind A. Eeles, Annie T W Chu, Florentia Fostira, Greet Wieme, Brita Arver, Charlotte Kvist Lautrup, Christoph Engel, Marion Gauthier-Villars, Daniel Barrowdale, Caroline Maria Rossing, Kenneth Offit, Kathleen Claes, Olufunmilayo I. Olopade, Penny Soucy, Alicia Barroso, Manuel R. Teixeira, Wendy K. Chung, Gero Kramer, Tsun Leung Chan, Agostina Stradella, Debra Frost, Noura Mebirouk, Liselotte P. van Hest, Esther Darder, Valentina Silvestri, Annabeth Høgh Petersen, Lesley McGuffog, Andrea Gehrig, Mary Porteous, Matti A. Rookus, Lizet E. van der Kolk, Siranoush Manoukian, Lone Sunde, Conxi Lázaro, Maria A. Caligo, Priyanka Sharma, Anne-Bine Skytte, Claus-Eric Ott, Christian Sutter, Paolo Radice, Veronica Medici, Georgia Chenevix-Trench, Vanesa García-Barberán, Kristiina Aittomäki, Amanda E. Toland, Anna Marie Mulligan, Véronique Mari, Bernd Dworniczak, Lynn Martin, Lara Della Puppa, Phuong L. Mai, George Fountzilas, Yen Y. Tan, Simona Agata, Torben A Kruse, Trinidad Caldés, Rosemarie Davidson, Daniel R. Barnes, Thomas Dyrso Jensen, Åke Borg, Mark E. Robson, Jennifer T. Loud, Vivian Y. Shin, Irene López-Perolio, Leigha Senter, Irene L. Andrulis, Rosa Scarpitta, Angela F. Brady, Annika Lindblom, Diana Torres, Lotte Nylandsted Krogh, Barbara Wappenschmidt, Muhammad Rashid, Jeroen Vierstraete, Mary B. Daly, Annelie Liljegren, Frederieke H. van der Baan, Eunyoung Kang, Alessandra Viel, Santiago Cabezas-Camarero, Eric Hahnen, Laura Matricardi, Marinus J. Blok, Edmond S. K. Ma, Maria Grazia Tibiletti, Catarina Santos, Julian Adlard, Soo Hwang Teo, Giuseppe Giannini, Jan Hauke, Peter J. Hulick, Miguel de la Hoya, Clare Miller, Bernardo Bonanni, Bent Ejlertsen, Lajos Géczi, Liliana Varesco, Orland Diez, N Herold, Christine Lasset, Adrià López-Fernández, Min Hyuk Lee, Medicum, Kristiina Aittomäki / Principal Investigator, HUSLAB, Department of Medical and Clinical Genetics, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, HUS Gynecology and Obstetrics, Clinicum, Department of Obstetrics and Gynecology, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Lab Centraal Lab (9), Medical Oncology, Academic Medical Center, ARD - Amsterdam Reproduction and Development, Leslie, Goska [0000-0001-5756-6222], Adlard, Julian [0000-0002-1693-0435], Arnold, Norbert [0000-0003-4523-8808], Auber, Bernd [0000-0003-1880-291X], Azzollini, Jacopo [0000-0002-9364-9778], Barnes, Daniel R [0000-0002-3781-7570], Brunet, Joan [0000-0003-1945-3512], Caligo, Maria A [0000-0003-0589-1829], Campbell, Ian G [0000-0002-7773-4155], Claes, Kathleen BM [0000-0003-0841-7372], Darder, Esther [0000-0002-7764-1397], Dennis, Joe [0000-0003-4591-1214], Dworniczak, Bernd [0000-0003-4981-7903], Eeles, Rosalind A [0000-0002-3698-6241], Ehrencrona, Hans [0000-0002-5589-3622], Ejlertsen, Bent [0000-0001-8761-714X], Evans, D Gareth [0000-0002-8482-5784], Garre, Pilar [0000-0001-8285-4138], Greene, Mark H [0000-0003-1852-9239], Hulick, Peter J [0000-0001-8397-4078], Jager, Agnes [0000-0002-7713-1450], James, Paul [0000-0002-4361-4657], John, Esther M [0000-0003-3259-8003], Joseph, Vijai [0000-0002-7933-151X], Kim, Sung-Won [0000-0002-1413-2800], Kim, Zisun [0000-0002-1413-2800], Konstantopoulou, Irene [0000-0002-0470-0309], Lesueur, Fabienne [0000-0001-7404-4549], Matricardi, Laura [0000-0002-0241-1810], Gomes, Denise Molina [0000-0002-2836-9008], Nevanlinna, Heli [0000-0002-0916-2976], Olopade, Olufunmilayo I [0000-0002-9936-1599], Palli, Domenico [0000-0002-5558-2437], Park, Sue K [0000-0001-5002-9707], Parsons, Michael T [0000-0003-3242-8477], Peterlongo, Paolo [0000-0001-6951-6855], Petersen, Annabeth Høgh [0000-0002-4503-6942], Pujana, Miguel Angel [0000-0003-3222-4044], Ruddy, Kathryn J [0000-0001-6298-332X], Scarpitta, Rosa [0000-0001-7590-3827], Shah, Payal D [0000-0001-5874-3390], Silvestri, Valentina [0000-0003-0712-9379], Southey, Melissa C [0000-0002-6313-9005], Spurdle, Amanda B [0000-0003-1337-7897], Stoppa-Lyonnet, Dominique [0000-0002-5438-8309], Sunde, Lone [0000-0002-8479-165X], Teixeira, Manuel R [0000-0002-4896-5982], Teo, Soo Hwang [0000-0002-0444-590X], Tommasi, Stefania [0000-0002-2157-2978], Toss, Angela [0000-0002-1854-6701], van der Luijt, Rob B [0000-0002-0018-1089], Vierstraete, Jeroen [0000-0001-7909-6620], Wieme, Greet [0000-0003-2718-5300], Yadav, Siddhartha [0000-0003-4630-9903], Antoniou, Antonis C [0000-0001-9223-3116], Apollo - University of Cambridge Repository, Human genetics, and CCA - Cancer biology and immunology
Subjects: Male, 0301 basic medicine, Oncology, Cancer Research, endocrine system diseases, PHENOTYPE, INCREASE, Prostate cancer, 0302 clinical medicine, Risk Factors, Young adult, skin and connective tissue diseases, Aged, 80 and over, Prostate cancer risk, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], MESSENGER-RNA DECAY, BRCA1 Protein, Genomics, GERMLINE MUTATIONS, Middle Aged, Prognosis, OVARIAN, CARRIERS, 3. Good health, 030220 oncology & carcinogenesis, Adult, Heterozygote, medicine.medical_specialty, Adolescent, Tumor suppressor gene, Urology, Association (object-oriented programming), 3122 Cancers, MEDLINE, Article, Young Adult, 03 medical and health sciences, Breast cancer, Germline mutation, SDG 3 - Good Health and Well-being, Internal medicine, BRCA1, BRCA2, Prostate Cancer, Pathogenic sequence variant location, Risk estimation, Journal Article, Genetic predisposition, medicine, Humans, BREAST-CANCER, Genetic Predisposition to Disease, Risk factor, Genetic Association Studies, Aged, BRCA2 Protein, IDENTIFICATION, business.industry, Prostatic Neoplasms, medicine.disease, GENE, Confidence interval, APC, 030104 developmental biology, Mutation, 3111 Biomedicine, business
Abstract: Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3′ region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25–2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63–5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71–4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12–11.54; P = 0.0002). No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. Significance: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
Published: 2020
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44. Smith-Magenis Syndrome—Clinical Review, Biological Background and Related Disorders

Author: Berardo Rinaldi, Roberta Villa, Alessandra Sironi, Livia Garavelli, Palma Finelli, and Maria Francesca Bedeschi
Subjects: Intellectual Disability, Trans-Activators, Genetics, Humans, Smith-Magenis Syndrome, Genetics (clinical), Transcription Factors
Abstract: Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by distinctive physical features, developmental delay, cognitive impairment, and a typical behavioral phenotype. SMS is caused by interstitial 17p11.2 deletions (90%), encompassing multiple genes and including the retinoic acid-induced 1 gene (RAI1), or by pathogenic variants in RAI1 itself (10%). RAI1 is a dosage-sensitive gene expressed in many tissues and acting as transcriptional regulator. The majority of individuals exhibit a mild-to-moderate range of intellectual disability. The behavioral phenotype includes significant sleep disturbance, stereotypes, maladaptive and self-injurious behaviors. In this review, we summarize current clinical knowledge and therapeutic approaches. We further discuss the common biological background shared with other conditions commonly retained in differential diagnosis.
Published: 2022
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45. 'COVID-19 and Obesity: Postoperative Risk in Patients Who Have Undergone Bariatric Surgery. Preliminary Report from High Volume Center in Italy (Lombardy)'

Author: Simone Targa, Stefano Olmi, Francesca Ciccarese, Giovanni Cesana, Ayman Ismail, Alberto Oldani, Roberta Villa, Adelinda Angela Giulia Zanoni, Matteo Uccelli, Stefano Maria De Carli, Riccardo Giorgi, Uccelli, M., Cesana, G. C., Ciccarese, F., Oldani, A., Zanoni, A. A. G., De Carli, S. M., Giorgi, R., Villa, R., Ismail, A., Targa, S., and Olmi, S.
Subjects: medicine.medical_specialty, 2019-20 coronavirus outbreak, Nutrition and Dietetics, Coronavirus disease 2019 (COVID-19), business.industry, Endocrinology, Diabetes and Metabolism, General surgery, MEDLINE, medicine.disease, Obesity, Postoperative risk, Preliminary report, High volume center, medicine, Surgery, In patient, business, Letter to the Editor
Published: 2020

46. Exon-trapping assay improves clinical interpretation of COL11A1 and COL11A2 intronic variants in stickler syndrome type 2 and otospondylomegaepiphyseal dysplasia

Author: Grazia Nardella, Roberta Villa, Silvia Morlino, Stefano Castellana, Vito Guarnieri, Marco Castori, Carmela Fusco, Maria Francesca Bedeschi, Annalisa Schirizzi, Paola Grammatico, Antonio Novelli, Emanuele Agolini, and Lucia Micale
Subjects: 0301 basic medicine, COL11A2, Otospondylomegaepiphyseal dysplasia, lcsh:QH426-470, In silico, 030105 genetics & heredity, Biology, stickler syndrome, COL11A1, 03 medical and health sciences, Exon, Exon trapping, Genetics, medicine, Stickler syndrome, Gene, Genetics (clinical), Stickler Syndrome Type 2, Fibrillogenesis, medicine.disease, lcsh:Genetics, 030104 developmental biology
Abstract: Stickler syndrome (SS) is a hereditary connective tissue disorder affecting bones, eyes, and hearing. Type 2 SS and the SS variant otospondylomegaepiphyseal dysplasia (OSMED) are caused by deleterious variants in COL11A1 and COL11A2, respectively. In both genes, available database information indicates a high rate of potentially deleterious intronic variants, but published evidence of their biological effect is usually insufficient for a definite clinical interpretation. We report four previously unpublished intronic variants in COL11A1 (c.2241 + 5G&gt, T, c.2809 &minus, 2A&gt, G, c.3168 + 5G&gt, C) and COL11A2 (c.4392 + 1G&gt, A) identified in type 2 SS/OSMED individuals. The pathogenic effect of these variants was first predicted in silico and then investigated by an exon-trapping assay. We demonstrated that all variants can induce exon in-frame deletions, which lead to the synthesis of shorter collagen XI &alpha, 1 or 2 chains. Lacking residues are located in the &alpha, triple helical region, which has a crucial role in regulating collagen fibrillogenesis. In conclusion, this study suggests that these alternative COL11A1 and COL11A2 transcripts might result in aberrant triple helix collagen. Our approach may help to improve the diagnostic molecular pathway of COL11-related disorders.
Published: 2020

47. Management of 69 Gastric Leakages after 4294 Consecutive Sleeve: The Experience of a High Volume Bariatric Center

Author: Riccardo Giorgi, Giovanni Cesana, Stefano Maria De Carli, Alberto Oldani, Roberta Villa, Ayman Ismail, Stefano Olmi, Francesca Ciccarese, Adelinda Angela Giulia Zanoni, Matteo Uccelli, Carolina Rubicondo, Olmi, S., Cesana, G., Rubicondo, C., Oldani, A., Uccelli, M., De Carli, S., Ciccarese, F., Giorgi, R., Villa, R., Zanoni, A., and Ismail, A.
Subjects: Sleeve gastrectomy, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Anastomotic Leak, Bariatric complications, 03 medical and health sciences, 0302 clinical medicine, Bariatrics, Gastrectomy, medicine, Humans, In patient, Lost to follow-up, Subclinical infection, Leakage (electronics), Retrospective Studies, Nutrition and Dietetics, Second line treatment, business.industry, Incidence (epidemiology), Stomach, Stent, Endogastric stent, Surgery, Obesity, Morbid, 030211 gastroenterology & hepatology, Laparoscopy, business, Leakage
Abstract: Purpose: To propose an algorithm of treatment for leakage after laparoscopic sleeve gastrectomy (LSG). Materials and Methods: Sixty-nine patients who developed gastric leakage out of 4294 patients who underwent LSG from 2010 to 2018 were considered in this study. Patients’ outcomes in terms of incidence of resolution and time to leakage resolution were compared by leakage characteristics and type of treatment. Three patients were lost to follow up. Results: Leakage occurred in a median of 6days from surgery, and for majority of patients (80.3%), it was in the upper part of the sleeve. The median dimension of leakage was 6.5mm. Low level leakage resulted in a lower time of resolution (p< 0.001). Patients with clinical leakage were treated with surgery or endoscopic placement of a self-expandable metal stent (SEMS). The median time of leakage resolution was 42days. The hospitalization time for SEMS was shorter with a 68.3% of complete resolution compared with the 29.4% of surgery. In patients with subclinical and small leakage, a conservative treatment was successful in 87.5%. Overall 39.4% of patients needed a second line treatment after that the first failed. Conclusion: Leakage could be treated conservatively if subclinical and < 5mm. Surgery is mandatory if a perigastric collection is present or an organ lesion is suspected. SEMS seems to be the best option to treat high level leakage.
Published: 2020

48. Modified laparoscopic sleeve gastrectomy with Rossetti antireflux fundoplication: results after 220 procedures with 24-month follow-up

Author: Alberto Oldani, Riccardo Giorgi, Roberta Villa, Giovanni Cesana, Stefano Olmi, Francesca Ciccarese, Stefano Maria De Carli, Matteo Uccelli, Olmi, S., Uccelli, M., Cesana, G. C., Ciccarese, F., Oldani, A., Giorgi, R., De Carli, S. M., and Villa, R.
Subjects: Male, medicine.medical_specialty, Sleeve gastrectomy, medicine.medical_treatment, Perforation (oil well), Population, Fundoplication, 030209 endocrinology & metabolism, Gastroesophageal reflux disease, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Weight loss, Gastrectomy, medicine, Humans, Esophagus, education, Retrospective Studies, education.field_of_study, business.industry, Stomach, GERD, medicine.disease, Dysphagia, digestive system diseases, Surgery, Obesity, Morbid, medicine.anatomical_structure, Treatment Outcome, Italy, 030211 gastroenterology & hepatology, Female, Laparoscopy, medicine.symptom, business, Esophagitis, Follow-Up Studies
Abstract: Background Gastroesophageal reflux disease (GERD), including erosive esophagitis, is highly prevalent in the obese population. Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric procedures. The relationship between LSG and GERD has gained increasing attention. This retrospective study aimed to assess the effectiveness of combined LSG and modified Rossetti antireflux fundoplication for the treatment of GERD on morbidly obese patients after bariatric surgery. Objectives To assess the effectiveness, on morbid obese patients, of combined SG and Rossetti fundoplication for the treatment of GERD in obese patients. Setting Public Hospital, Italy. Methods From January 2015 to May 2018, 220 obese patients (167 female; 53 male) underwent LSG and modified Rossetti antireflux fundoplication procedure, performed by 4 different expert bariatric surgeons. Data have been collected in an Excel file and processed by XLStat to perform statistical analyses. We analyzed short-term complications and medium-term results with 24-month follow-up in terms of weight loss, remission of co-morbidities, and resolution of GERD. Results Mean BMI was 42.58 ± 5.93 kg/m2 (range, 31.70–63.16). Patients suffering from GERD before surgery were 137 of 220 (62.3%). No intraoperative complications or conversion were reported. Regular postoperative course was recorded in 90% of patients (198 of 220 patients). Gastric perforation has always occurred on the fundoplicated portion of the stomach. This perforation, which is different from the well-known post-LSG gastric fistula, may be because of incorrect gastric fundus manipulation. Rate of reoperation was 14 of 220 (6.4%). A good sense of repletion without episodes of vomiting, nausea, or dysphagia was reported in 95% of the analyzed patients. Of patients, 98.5% did not suffer from reflux symptoms and did not take proton pump inhibitors. A decrease in BMI and percent of total weight loss at follow-up were comparable with LSG. Endoscopic follow-up is still ongoing. Improvement in esophagitis was observed in 63 of 65 (96.92%) patients and all 4 patients shows improvement in Barrett’s esophagus. Conclusions LSG and modified Rossetti antireflux fundoplication procedure is a tolerated and feasible procedure in obese patients, with good postoperative weight loss results and improvement in GERD.
Published: 2020

49. A Preliminary Clinical Evaluation of a Topical Product for Reducing Slight Rosacea Imperfections

Author: Daniele, Maggioni, Annamaria, Cimicata, Antonella, Praticò, Roberta, Villa, Ferdinando Marco, Bianchi, Silvia, Busoli Badiale, and Claudio, Angelinetta
Subjects: integumentary system, transepidermal water loss, skin redness, telangiectasia, topical product, Original Research, rosacea
Abstract: Introduction Rosacea is a chronic multifactorial skin disorder mainly affecting facial skin with an estimated prevalence of about 5% worldwide. Its main symptoms, occurring early during pathology development, are skin dehydration, redness, erythema, and telangiectasia. Given the lack of a resolutive cure, therapeutic approaches able to relieve the main symptoms are needed. Purpose The aim of this research article is to evaluate the beneficial effect of a topical product (Serum BK46) on rosacea symptoms. Patients and Methods A monocentric single-arm, non-blinded study was performed to assess the clinical effect of Serum BK46 in relieving the main symptoms of rosacea: skin dryness, increased trans epidermal water loss (TEWL), redness, and abnormal vascularization. Twenty patients with mild to moderate rosacea were enrolled in the study and asked to apply the product twice per day for 56 days. Skin moisturization, TEWL, and erythema index were instrumentally assessed at baseline and following 24 h and 14, 28 and 56 days of treatment. Clinical parameters, including redness and telangiectasia imperfection visibility, were evaluated on a 5-point scale by a specialized dermatologist at baseline and after 14, 28, and 56 days of treatment. Finally, the visibility of vessel diameter was evaluated at baseline and after 28 and 56 days of treatment. Results Serum BK46 application restored skin hydration and prevented the loss of water by the skin. Long-term treatment with Serum BK46 significantly reduced skin redness, erythema index, and the visibility of telangiectasia imperfections and superficial vessels. The investigated product's clinical effect was demonstrated by both instrumental and clinical evaluation. Furthermore, Serum BK46 was completely tolerated and no adverse effects were recorded. Conclusion The moisturizing and skin barrier restoring action of Serum BK46 has been clearly proven in patients displaying mild to moderate rosacea; thus, this product is a good candidate for rosacea treatment.
Published: 2019

50. Association of Genomic Domains in

Author: Vivek L, Patel, Evan L, Busch, Tara M, Friebel, Angel, Cronin, Goska, Leslie, Lesley, McGuffog, Julian, Adlard, Simona, Agata, Bjarni A, Agnarsson, Munaza, Ahmed, Kristiina, Aittomäki, Elisa, Alducci, Irene L, Andrulis, Adalgeir, Arason, Norbert, Arnold, Grazia, Artioli, Brita, Arver, Bernd, Auber, Jacopo, Azzollini, Judith, Balmaña, Rosa B, Barkardottir, Daniel R, Barnes, Alicia, Barroso, Daniel, Barrowdale, Muriel, Belotti, Javier, Benitez, Birgitte, Bertelsen, Marinus J, Blok, Istvan, Bodrogi, Valérie, Bonadona, Bernardo, Bonanni, Davide, Bondavalli, Susanne E, Boonen, Julika, Borde, Ake, Borg, Angela R, Bradbury, Angela, Brady, Carole, Brewer, Joan, Brunet, Bruno, Buecher, Saundra S, Buys, Santiago, Cabezas-Camarero, Trinidad, Caldés, Almuth, Caliebe, Maria A, Caligo, Mariarosaria, Calvello, Ian G, Campbell, Ileana, Carnevali, Estela, Carrasco, Tsun L, Chan, Annie T W, Chu, Wendy K, Chung, Kathleen B M, Claes, Gemo Study, Collaborators, Embrace, Collaborators, Jackie, Cook, Laura, Cortesi, Fergus J, Couch, Mary B, Daly, Giuseppe, Damante, Esther, Darder, Rosemarie, Davidson, Miguel, de la Hoya, Lara Della, Puppa, Joe, Dennis, Orland, Díez, Yuan Chun, Ding, Nina, Ditsch, Susan M, Domchek, Alan, Donaldson, Bernd, Dworniczak, Douglas F, Easton, Diana M, Eccles, Rosalind A, Eeles, Hans, Ehrencrona, Bent, Ejlertsen, Christoph, Engel, D Gareth, Evans, Laurence, Faivre, Ulrike, Faust, Lídia, Feliubadaló, Lenka, Foretova, Florentia, Fostira, George, Fountzilas, Debra, Frost, Vanesa, García-Barberán, Pilar, Garre, Marion, Gauthier-Villars, Lajos, Géczi, Andrea, Gehrig, Anne-Marie, Gerdes, Paul, Gesta, Giuseppe, Giannini, Gord, Glendon, Andrew K, Godwin, David E, Goldgar, Mark H, Greene, Angelica M, Gutierrez-Barrera, Eric, Hahnen, Ute, Hamann, Jan, Hauke, Natalie, Herold, Frans B L, Hogervorst, Ellen, Honisch, John L, Hopper, Peter J, Hulick, KConFab, Investigators, Hebon, Investigators, Louise, Izatt, Agnes, Jager, Paul, James, Ramunas, Janavicius, Uffe Birk, Jensen, Thomas Dyrso, Jensen, Oskar Th, Johannsson, Esther M, John, Vijai, Joseph, Eunyoung, Kang, Karin, Kast, Johanna I, Kiiski, Sung-Won, Kim, Zisun, Kim, Kwang-Pil, Ko, Irene, Konstantopoulou, Gero, Kramer, Lotte, Krogh, Torben A, Kruse, Ava, Kwong, Mirjam, Larsen, Christine, Lasset, Charlotte, Lautrup, Conxi, Lazaro, Jihyoun, Lee, Jong Won, Lee, Min Hyuk, Lee, Johannes, Lemke, Fabienne, Lesueur, Annelie, Liljegren, Annika, Lindblom, Patricia, Llovet, Adria, Lopez-Fernández, Irene, Lopez-Perolio, Victor, Lorca, Jennifer T, Loud, Edmond S K, Ma, Phuong L, Mai, Siranoush, Manoukian, Veronique, Mari, Lynn, Martin, Laura, Matricardi, Noura, Mebirouk, Veronica, Medici, Hanne E J, Meijers-Heijboer, Alfons, Meindl, Arjen R, Mensenkamp, Clare, Miller, Denise Molina, Gomes, Marco, Montagna, Thea M, Mooij, Lidia, Moserle, Emmanuelle, Mouret-Fourme, Anna Marie, Mulligan, Katherine L, Nathanson, Marie, Navratilova, Heli, Nevanlinna, Dieter, Niederacher, Finn C Cilius, Nielsen, Liene, Nikitina-Zake, Kenneth, Offit, Edith, Olah, Olufunmilayo I, Olopade, Kai-Ren, Ong, Ana, Osorio, Claus-Eric, Ott, Domenico, Palli, Sue K, Park, Michael T, Parsons, Inge Sokilde, Pedersen, Bernard, Peissel, Ana, Peixoto, Pedro, Pérez-Segura, Paolo, Peterlongo, Annabeth Høgh, Petersen, Mary E, Porteous, Miguel Angel, Pujana, Paolo, Radice, Juliane, Ramser, Johanna, Rantala, Muhammad U, Rashid, Kerstin, Rhiem, Piera, Rizzolo, Mark E, Robson, Matti A, Rookus, Caroline M, Rossing, Kathryn J, Ruddy, Catarina, Santos, Claire, Saule, Rosa, Scarpitta, Rita K, Schmutzler, Hélène, Schuster, Leigha, Senter, Caroline M, Seynaeve, Payal D, Shah, Priyanka, Sharma, Vivian Y, Shin, Valentina, Silvestri, Jacques, Simard, Christian F, Singer, Anne-Bine, Skytte, Katie, Snape, Angela R, Solano, Penny, Soucy, Melissa C, Southey, Amanda B, Spurdle, Linda, Steele, Doris, Steinemann, Dominique, Stoppa-Lyonnet, Agostina, Stradella, Lone, Sunde, Christian, Sutter, Yen Y, Tan, Manuel R, Teixeira, Soo Hwang, Teo, Mads, Thomassen, Maria Grazia, Tibiletti, Marc, Tischkowitz, Silvia, Tognazzo, Amanda E, Toland, Stefania, Tommasi, Diana, Torres, Angela, Toss, Alison H, Trainer, Nadine, Tung, Christi J, van Asperen, Frederieke H, van der Baan, Lizet E, van der Kolk, Rob B, van der Luijt, Liselotte P, van Hest, Liliana, Varesco, Raymonda, Varon-Mateeva, Alessandra, Viel, Jeroen, Vierstraete, Roberta, Villa, Anna, von Wachenfeldt, Philipp, Wagner, Shan, Wang-Gohrke, Barbara, Wappenschmidt, Jeffrey N, Weitzel, Greet, Wieme, Siddhartha, Yadav, Drakoulis, Yannoukakos, Sook-Yee, Yoon, Cristina, Zanzottera, Kristin K, Zorn, Anthony V, D'Amico, Matthew L, Freedman, Mark M, Pomerantz, Georgia, Chenevix-Trench, Antonis C, Antoniou, Susan L, Neuhausen, Laura, Ottini, Henriette Roed, Nielsen, and Timothy R, Rebbeck
Subjects: Adult, Aged, 80 and over, BRCA2 Protein, Male, Heterozygote, Adolescent, BRCA1 Protein, Prostatic Neoplasms, Genomics, Middle Aged, Prognosis, Young Adult, Risk Factors, Mutation, Humans, Genetic Predisposition to Disease, Genetic Association Studies, Aged
Abstract: Pathogenic sequence variants (PSV) in
Published: 2019

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