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To assess effectiveness of a rapid recovery pathway (RRP) without epidural catheter analgesia (ECA) or intravenous patient controlled analgesia (PCA) in accelerating recovery and decreasing opioid consumption in patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion (PSF).A retrospective cohort study included collection of demographics, ECA use, IV PCA, postoperative opioid consumption, postoperative pain scores, and reoperation rate. Opioid consumption was calculated using morphine milligram equivalents (MME). Hospital length of stay (HLOS) and first reported ambulation with physical therapy (PT) were also recorded.53 patients were included, with 18 in the RRP group. Patient characteristics were comparable between the groups, except in ECA use and BMI. The RRP group consumed less total MME from postoperative day (POD) 0 to 2 (mean difference 61.6 MME; 95% CI 37.1-86.1 MME; p 0.001). In addition, the RRP group had significantly shorter HLOS (2.5 vs 4.0 days; p 0.001). There were no differences in VAS scores between the two groups. A subset analysis comparing patients who did and did not receive ECA showed that ECA resulted in overall higher inpatient MME and HLOS. A prediction model was developed using multiple regression based on the different medications used for multimodal analgesia (MMA) in the RRP.An RRP without the use of ECA or IV PCA can provide adequate analgesia in patients with AIS undergoing PSF while lowering inpatient narcotic consumption and accelerating immediate postoperative recovery.

Education delivery had to evolve during the Covid-19 pandemic as children could no longer have face-to-face contact with peers and teachers, as formal education would previously have allowed. Due to this a practitioner enquiry approach was adopted, to determine whether online cooperative learning would increase peer connections, reduce loneliness, and make education less boring/more engaging. Five academic weeks into lockdown, 16 pupils from primary six and seven took part in a cooperative learning task using Google Meet for video conferencing (N=16). Pupils were asked questions about their experiences which were analysed using content analysis. Prior to the task, pupils commented about their experience of lockdown with the most frequent comments about boredom, missing friends and family, and worry. Following the task, the most common responses were about seeing and talking to friends, enjoyment and wishing to use Google Meet again. Areas for future research are considered and implications for practice for schools, psychological services and the wider authority are explored.

OBJECTIVEPrevious reports have addressed the short-term response of patients with Chiari-related scoliosis (CRS) to suboccipital decompression and duraplasty (SODD); however, the long-term behavior of the curve has not been well defined. The authors undertook a longitudinal study of a cohort of patients who underwent SODD for CRS to determine whether there are factors related to Chiari malformation (CM) that predict long-term scoliotic curve behavior and need for deformity correction.METHODSThe authors retrospectively reviewed cases in which patients underwent SODD for CRS during a 14-year period at a single center. Clinical (age, sex, and associated disorders/syndromes) and radiographic (CM type, tonsillar descent, pBC2 line, clival-axial angle [CXA], syrinx length and level, and initial Cobb angle) information was evaluated to identify associations with the primary outcome: delayed thoracolumbar fusion for progressive scoliosis.RESULTSTwenty-eight patients were identified, but 4 were lost to follow-up and 1 underwent fusion within a year. Among the remaining 23 patients, 11 required fusion surgery at an average of 88.3 ± 15.4 months after SODD, including 7 (30%) who needed fusion more than 5 years after SODD. On univariate analysis, a lower CXA (131.5° ± 4.8° vs 146.5° ± 4.6°, p = 0.034), pBC2 > 9 mm (64% vs 25%, p = 0.06), and higher initial Cobb angle (35.1° ± 3.6° vs 22.8° ± 4.0°, p = 0.035) were associated with the need for thoracolumbar fusion. Multivariable modeling revealed that lower CXA was independently associated with a need for delayed thoracolumbar fusion (OR 1.12, p = 0.0128).CONCLUSIONSThis investigation demonstrates the long-term outcome and natural history of CRS after SODD. The durability of the effect of SODD on CRS and curve behavior is poor, with late curve progression occurring in 30% of patients. Factors associated with CRS progression include an initial pBC2 > 9 mm, lower CXA, and higher Cobb angle. Lower CXA was an independent predictor of delayed thoracolumbar fusion. Further study is necessary on a larger cohort of patients to fully elucidate this relationship.

This synthesis documents the performance tests used in conjunction with volumetric properties for mixtures. Performance tests are intended to extend service life by guiding material selection (i.e., asphalt binder and aggregate) and proportions (i.e., asphalt content and gradations). The synthesis provides examples of engineering tools used in the development and implementation of performance specifications for asphalt mixtures, examples of the contents of performance-based specifications (PBS) currently used or in development, information on test program implementation and research efforts related to PBS for asphalt mixtures, and the reported benefits and challenges with implementing PBS. Information for this report was acquired through a literature search, a survey of the use of performance specifications for asphalt mixtures, and seven case examples from six state departments of transportation, and the city of Edmonton, Alberta, Canada.

Objective To examine the nutritional quality of food in television food advertisements that are targeted at children. Method We videotaped 42 hours of children's programs and analysed the food advertisements' content and nutrient composition using the New Zealand Food Composition Database. Results Of 269 food advertisements, 63% were for foods 'high in fat and/or sugar'. Children who ate only the advertised foods would eat a diet too high in fat, saturated fat, protein, free sugars and sodium. Furthermore, their diets would have suboptimal levels of fibre and suboptimal intakes of a number of important micronutrients (depending on age), including magnesium, selenium and vitamin E. The food products advertised on this channel rarely included nutritious low-cost foods that are necessary for food security in low-income groups. There were also no food advertisements that included any of the healthy foods consumed by Maori and Pacific peoples. Conclusions Food advertisements targeted at children generally reflect the dietary pattern associated with an increased risk of obesity and dental caries in childhood; and cardiovascular disease, diabetes and cancers in adulthood.

The electrochemistry and electronic absorption spectroscopy of metal-metal-bonded chloride clusters derived from the {Nb 6 Cl 12 } z+ (z=1-4) cores were investigated in the room-temperature molten salt aluminum(III) chloride-1-methyl-3-ethylimidazolium chloride (AlCl 3 -MeEtimCl). Anionic complexes of this core cluster of the type [(Nb 6 Cl 12 )Cl 6 ] (6-z) were identified in basic melt

The James Webb Space Telescope (JWST) is a 6.6m diameter, segmented, deployable telescope for cryogenic IR space astronomy (approximately 40K). The JWST Observatory architecture includes the Optical Telescope Element and the Integrated Science Instrument Module (ISIM) element that contains four science instruments (SI) including a Guider. The ISM optical metering structure is a roughly 2.2x1.7x2.2m, asymmetric frame that is composed of carbon fiber and resin tubes bonded to invar end fittings and composite gussets and clips. The structure supports the SIs, isolates the SIs from the OTE, and supports thermal and electrical subsystems. The structure is attached to the OTE structure via strut-like kinematic mounts. The ISIM structure must meet its requirements at the approximately 40K cryogenic operating temperature. The SIs are aligned to the structure's coordinate system under ambient, clean room conditions using laser tracker and theodolite metrology. The ISIM structure is thermally cycled for stress relief and in order to measure temperature-induced mechanical, structural changes. These ambient-to-cryogenic changes in the alignment of SI and OTE-related interfaces are an important component in the JWST Observatory alignment plan and must be verified. We report on the planning for and preliminary testing of a cryogenic metrology system for ISIM based on photogrammetry. Photogrammetry is the measurement of the location of custom targets via triangulation using images obtained at a suite of digital camera locations and orientations. We describe metrology system requirements, plans, and ambient photogrammetric measurements of a mock-up of the ISIM structure to design targeting and obtain resolution estimates. We compare these measurements with those taken from a well known ambient metrology system, namely, the Leica laser tracker system. We also describe the data reduction algorithm planned to interpret cryogenic data from the Flight structure. Photogrammetry was selected from an informal trade study of cryogenic metrology systems because its resolution meets sub-allocations to ISIM alignment requirements and it is a non-contact method that can in principle measure six degrees of freedom changes in target location. In addition, photogrammetry targets can be readily related to targets used for ambient surveys of the structure. By thermally isolating the photogrammetry camera during testing, metrology can be performed in situ during thermal cycling. Photogrammetry also has a small but significant cryogenic heritage in astronomical instrumentation metrology. It was used to validate the displacement/deformation predictions of the reflectors and the feed horns during thermal/vacuum testing (90K) for the Microwave Anisotropy Probe (MAP). It also was used during thermal vacuum testing (100K) to verify shape and component alignment at operational temperature of the High Gain Antenna for New Horizons. With tighter alignment requirements and lower operating temperatures than the aforementioned observatories, ISIM presents new challenges in the development of this metrology system.

A photolabile azido derivative of the kaurene oxidase inhibitor 1-(4-chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-l-yl) pentan-3-ol (paclobutrazol) has been synthesized for use as a photoaffinity labeling agent. The compound was tested as an inhibitor of the oxidation of ent-kaurene catalyzed by cell-free preparations from endosperm of Cucurbita maxima. The I(50) of the azido derivative was 9.5 nanomolar, which compares well with that of paclobutrazol (6.3 nanomolar in our measurements). The azido compound bound to Cytochrome P-450 in microsomes from Cucurbita maxima, and induced a Type II spectral change, with an apparent binding constant of 0.24+/-0.04 micromolar.

The variable star HD 136905, recently designated GX Librae, is a chromospherically active K1 III single-lined spectroscopic binary with a period of 11.1345 days. It has moderate strength Ca II H and K and ultraviolet emission features, while H-alpha is strongly in absorption. The inclination of the system is 58 + or - 17 deg and the unseen secondary is most likely a G or K dwarf. The v sin i of the primary, 32 + or - 2 km/s, results in a minimum radius of 7.0 + or - 0.4 solar radii. Since the star fills a substantial fracture of its Roche lab, the double-peaked limit curve seen by photometric observers is predominantly ellipsoidal in nature. Both the photometry and the spectroscopy yield values for the period and the time of conjunction that are identical within their uncertainties.

The results of an extensive study of the eighth-magnitude G star HD 8358 employing optical photometry and spectroscopy, as well as UV observations with the IUE satellite, are presented. The star is found to be an active chromosphere binary with orbital and photometric period of 0.516 days. It exhibits photometric variability of 0.1-0.2 mg in V, due to starspots. At times the light curve is stable for several months, indicating that the spots persist essentially unchanged for more than 200 rotations. At other times, the spot configuration changes in a month or less. HD 8358 is an unusual member of the 'short-period' group of active chromosphere binaries due to its high space velocity and its very broad and highly variable H-alpha emission.

The authors have derived the spatial distribution of the electron temperature and density and the ionic abundances of O+, O++, N+, and S+ from CCD images of the planetary nebulae NGC 40 and NGC 6826 taken in the important emission lines of [O II], [O III], Hβ, [N II], and [S II]. Advantages of the imaging technique include complete spatial coverage and excellent spatial resolution, good light throughput, reduced effects of spatial averaging over filamented and knotted regions, elimination of the effects of atmospheric dispersion, and absolute spectrophotometry for objects having angular sizes of several arcmin. The disadvantages include additional effort to analyze the data, limited spectral coverage, and added difficulties in deblending nearby lines, removing the nebular continuum contribution, and correcting for nonphotometric conditions.

Spectroscopic observations of the chromospherically active G5 IV single-lined binary HD 26337 = EI Eri are presented. An orbital period of 1.94722 days is found for the star. It has moderately strong Ca II H and K emission and strong ultraviolet emission features, while H-alpha is a weak absorption feature that is variable in strength. The inclination of the system is 46 + or - 12 deg, and the unseen secondary is probably a late K or early M dwarf. The v sin i of the primary is 50 + or - 3 km/s, resulting in a minimum radius of 1.9 + or - 0.1 solar radius. The star is within the required limits for Doppler imaging. The primary is close to filling its Roche lobe, resulting in a strong constraint that the mass ratio is 2.6 or greater, with a primary mass of at least 1.4 solar mass. The distance to the system is estimated at 75 pc.

New optical spectroscopic and photometric data are presented for the active chromosphere FK Com candidate UZ Lib. The star is shown to have an extremely large photometric amplitude in V of 0.35 mag, and its rotation period is established as 4.75 + or - 0.01 days. The optical spectrum is that of an early K giant, broadened by a rotation velocity of approximately 65 km/s. H-alpha is visible as a very broad emission feature, with a profile resembling that seen in FK Com. The emission intensity and profile are variable over the rotation period, with the strongest emission present at photometric minimum, in accord with dark starspot models. The photospheric absorption line profiles show variable asymmetries and distortions which are interpreted as due to the effects of the dark starspot rotating across the line of sight. New radial velocity measures are combined with published data to demonstrate the UZ Lib is a member of a binary system in synchronous rotation with a secondary of mass approximately 0.5 solar masses. This information is considered in light of the conflicting models for the origin of the optical and spectral variability of the FK Com stars, as well as their uncertain evolutionary status.