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Introduction Routine collection of patient-reported outcome measures (PROMs) has the potential to inform and improve cancer care. It is now feasible for patients to complete PROMs electronically (ePROMs) providing information about their current levels of symptoms, side effects of treatment and other concerns. PROM scores can be tracked over time allowing more timely identification of problems and more appropriate intervention. Studies have reported clear benefits in patient–clinician communication when PROMs are used and trials in the USA and France found patients randomised to complete regular ePROMs reported better health-related quality of life, had fewer unplanned hospital visits and, importantly, significantly better survival than those randomised to usual care. However, information about the effects on health outcomes and, particularly, the cost-effectiveness of incorporating this information into practice is limited.Methods and analysis PROMISE (Patient Reported Outcome Measures in cancer care: a hybrid effectiveness-Implementation trial to optimise Symptom control and health service Experience) is a multicentre, randomised hybrid effectiveness/implementation trial to evaluate the clinical and cost-effectiveness of using ePROMs in routine cancer care to improve patient outcomes. Participants (target sample=572; randomised 1:1 to intervention and control) are adults aged 18 years or older diagnosed with a solid cancer and starting treatment at one of the four study hospitals. The primary outcomes are unplanned hospital presentations and physical/functional well-being at 6 months. We hypothesise that, compared with usual care, patients randomised to use an ePROM tool will have fewer unplanned hospital presentations, report better health-related quality of life and greater satisfaction with their care and that the ePROM tool will be cost-effective. We will also assess implementation and process outcomes consistent with the RE-AIM (Reach Effectiveness Adoption Implementation Maintenance) Framework.Ethics and dissemination This trial has been approved by the Metro South Human Research Ethics Committee (HREC/2020/QMS/67441). Participants provide written informed consent, including consent for record linkage, prior to completing the baseline questionnaire. Study results will be disseminated via peer-reviewed journals and presentations at scientific conferences and clinical meetings.Trial registration number ACTRN12620001290987.

Abstract The most critical step for methylmercury (MeHg) bioaccumulation in aquatic food webs is phytoplankton uptake of dissolved MeHg. Dissolved organic matter (DOM) has been known to influence MeHg uptake, but the mechanisms have remained unclear. Here we show that the concentration of DOM-associated thiol functional groups (DOM-RSH) varies substantially across contrasting aquatic systems and dictates MeHg speciation and bioavailability to phytoplankton. Across our 20 study sites, DOM-RSH concentrations decrease 40-fold from terrestrial to marine environments whereas dissolved organic carbon (DOC), the typical proxy for MeHg binding sites in DOM, only has a 5-fold decrease. MeHg accumulation into phytoplankton is shown to be directly linked to the concentration of specific MeHg binding sites (DOM-RSH), rather than DOC. Therefore, MeHg bioavailability increases systematically across the terrestrial-marine aquatic continuum as the DOM-RSH concentration decreases. Our results strongly suggest that measuring DOM-RSH concentrations will improve empirical models in phytoplankton uptake studies and will form a refined basis for modeling MeHg incorporation in aquatic food webs under various environmental conditions.

Museums that commemorate war have a uniquely influential role in determining how the nation approaches its past, and navigate highly politicized issues of loss and victimhood. Far less understood is how curatorial approaches to historical conflicts can influence museum practices regarding more recent wars. In this article, we explore how three museums of national history in Serbia narrate historical wars. Each museum is focused on articulating the story of the nation, albeit with markedly differing emphases in their collecting practices and curatorial strategies. Analysing objects and narrative texts, we suggest that Serbian historical museums engage visitors in ethical questions and topics that are often otherwise silenced. We draw attention to the resurgence of deep historical narratives, emphasizing Serbs’ connection to the environment, faith, and landscape, as a means to assert the continued relevance of historical wars to contemporary national identity. In doing so, museums seek to engage in the fraught politics of memory relating to the Yugoslav Wars.

ABSTRACT Hydrological modeling in decision-making is particularly challenging in tropical countries such as Brazil. There are numerous modeling tools; however, many applications have focused on watersheds with a total area of 0.6 in all sub-basins on a monthly basis. We also explored how four contrasting land use scenarios affected four water-flow variables (surface runoff, base flow, percolation, and total streamflow). Our results show that by using multiple flow-monitoring stations and multisite calibration approaches, ecohydrological models can be useful for managing basin-extent water resources in countries of continental dimensions such as Brazil.

ABSTRACT Environmental degradation from human pressures includes the conversion of native vegetation cover into pastures and cropland, as well as riparian deforestation, leading to river siltation, biotic homogenization, and loss of ecosystem services. The objective of our study was to evaluate water quality and benthic macroinvertebrate assemblage structure in response to changes in land use at local and buffer spatial extents. We assumed that human disturbances negatively affect water quality and macroinvertebrate assemblage condition. Greater human influence was observed at the local extent (Local Disturbance Index – LDI) than at the buffer (Buffer Disturbance Index – BDI) extent. Likewise, biological metric responses were stronger relative to the LDI than to the BDI or to the Integrated Disturbance Index (IDI). These results support establishing a biomonitoring program for assessing water body quality in the Doce River basin to facilitate conserving aquatic biodiversity and ecosystem services in the upper Graipu River.

There is an increasing demand for raw meat-based diets (RMBDs) for dogs, but these foods cannot be heat-pasteurized. Thus, the objective of this study was to evaluate the antimicrobial efficacy of encapsulated and dry-plated glucono delta lactone (GDL), citric acid (CA), and lactic acid (LA) when challenged against Salmonella enterica inoculated in a model raw meat-based diet (RMBDs) for dogs. Nutritionally complete, raw diets were formulated with different levels (1.0, 2.0 and 3.0% (w/w)) of both encapsulated and dry-plated GDL, CA, and LA with both the positive (PC) and the negative controls (NC) without acidulants. The diets were formed into patties of ∼100 g and inoculated with 3-cocktail mixtures of Salmonella enterica serovars, excluding the NC to achieve a final concentration of ∼6.0 Log CFU/patty. Microbial analyses were performed on the inoculated diets and survivors of S. enterica enumerated. Both encapsulated and dry-plated CA and LA had higher log reductions compared to GDL (P 0.05) and preserved product quality compared to the dry-plated acidulants at 1.0%. We concluded that 1.0% (w/w) of encapsulated citric or lactic acids could be successfully applied as an antimicrobial intervention in raw diets for dogs.

After the end of Latin American dictatorships, scholars closely analyzed the relationship between violence, memory and democracy. But these societies have continued to grapple not only with the legacy of authoritarian governments but with centuries of colonial power, with the result that many of the assumptions of earlier scholars are now being revisited. Intersectional questions of race, indigeneity and gender continue to refashion our understanding of memory and injustice. These questions frame this introductory article, in which we argue that Latin American contemporary social mobilisation that has denounced recent and long-term violence is constituted through intervention and creation of heritage from below. We propose that the interdisciplinary field of Critical Heritage Studies, that has burgeoned recently in the region, offers a means to understand how space, scale, and society interact to create meanings and work through violent pasts. The works of this Special Collection extend traditional conceptions of urban heritage as the mere conservation of cities’ landscape, towards the study of the relation between cultural geographies and the production of social mobilizations in Latin America. These geographies enable unique formulations of protest for activists, creating new capacities to contest recent and long-term human rights abuse. Resumen: Herencia desde abajo en Latinoamérica: Protestas urbanas y la lucha por los Derechos Humanos Tras el fin de las dictaduras latinoamericanas, las/os académicos de la región analizaron de cerca la relación entre violencia, memoria y democracia. Pero estas sociedades han seguido lidiando con el legado de los gobiernos autorita-rios y con siglos de abuso colonial, por lo que muchos de los supuestos de estos primeros estudios ahora están siendo examinados. Preguntas sobre la interseccionalidad racial, indígena y de género continúan reformulando nuestra comprensión sobre la relación entre la memoria y la injusticia. Estas preguntas guían este artículo introductorio, en el que sostenemos que la movilización social contemporánea en Latinoamérica que ha denunciado las violencias recientes y de larga data se constituyen a través de la intervención y la creación de patrimonio desde abajo. Proponemos que el campo interdisciplinario de Estudios Críticos del Patrimonio, que ha florecido recientemente en la región, ofrece un medio para comprender cómo el espacio, sus diferentes escalas y la sociedad interactúan para crear significados y elaborar sus pasados de violencia y opresión. Los trabajos de este número especial amplían las concepciones tradicionales del patrimonio urbano como la mera conservación del paisaje de las ciudades, hacia el estudio de la relación entre geografías culturales y la producción y performance de movilizaciones sociales en la región. Estas geografías constituyen de forma única las protestas y sus significados, creando nuevas capacidades para luchar en contra de las violencias recientes y coloniales.

There have been extensive studies of the struggles against Latin American military dictatorships of the 1960s and 1980s, especially regarding the activism of mothers of political activists who were disappeared. However there has been far less research about women’s continued struggle for memory, truth, and justice in contemporary Latin America. There has been even less consideration of how small-scale urban protesters use memory within urban cultural geographies of activism. This article explores the production of political memory by mothers of victims of state violence in Rio de Janeiro. The mother’s struggle encompasses heritage practices in 'favelas', as well as in the central business district, but deliberately recall and amplify the claims for justice from the 1960s and 1980s. This recalls not only the heritage connected with the dictatorship, but situates their practices within activists’ lived experiences of the colonial state and its attempts to render their murdered children criminals. Resumen: “Luchamos por la memoria de nuestros hijos”: Memoria política, patrimonio de favela y madres de víctimas de violencia estatal Existen amplios estudios sobre las luchas contra las dictaduras militares latinoamericanas de los años sesenta y ochenta, sobretodo sobre el activismo de las madres de los activistas políticos desaparecidos. Sin embargo, apenas se ha investigado la continua lucha de las mujeres por la memoria, la verdad y la justicia en la América Latina contemporánea; y aún menos cómo los manifestantes urbanos a pequeña escala utilizan la memoria dentro de las geografías culturales urbanas del activismo. Este artículo explora la producción de memoria política por parte de las madres de las víctimas de la violencia estatal en Río de Janeiro. Su lucha abarca prácticas patrimoniales en las favelas y en el distrito comercial central, pero recuerda y amplifica deliberadamente las reivindicaciones de justicia de los años sesenta y ochenta. No solo recuerda la herencia relacionada con la dictadura, sino que sitúa sus prácticas dentro de las experiencias vividas por los activistas del estado colonial y sus intentos de convertir a sus hijos asesinados en criminales.

Coincidence experiments at free-electron lasers enable time resolved site-specific investigations of molecular photochemistry at high signal rates, but isolating individual dissociation processes still poses a considerable technical challenge. Here, the authors use electron-ion partial covariance imaging to isolate otherwise elusive chemical shifts in UV-induced photofragmentation pathways of the prototypical chiral molecule 1-iodo-2-methylbutane.

Gene copy number variation across individuals has been shown to track population structure and be a source of adaptive genetic variation with significant fitness impacts. In this study, we report opposite results for both predictions based on the analysis of gene copy number variants (CNVs) of Suillus brevipes, a mycorrhizal fungus adapted to coastal and montane habitats in California. In order to assess whether gene copy number variation mirrored population structure and selection in this species, we investigated two previously studied locally adapted populations showing a highly differentiated genomic region encompassing a gene predicted to confer salt tolerance. In addition, we examined whether copy number in the genes related to salt homeostasis was differentiated between the two populations. Although we found many instances of CNV regions across the genomes of S. brevipes individuals, we also found CNVs did not recover population structure and known salt-tolerance-related genes were not under selection across the coastal population. Our results contrast with predictions of CNVs matching single-nucleotide polymorphism divergence and showed CNVs of genes for salt homeostasis are not under selection in S. brevipes.

The residues from the internal surface of four archaeological ceramic sherds, excavated from the Armenian Gardens, Jerusalem were analysed to characterise the contents of the original vessel. The sherds derive from four small, thick-walled, sphero-conical vessels recovered from a destruction layer, dating between the 11th and 12th century, Jerusalem. The residue has been analysed using light microscopy, biochemical characterisation, gas chromatography mass spectroscopy, inductively coupled plasma atomic emission spectroscopy and cold vapour atomic fluorescence spectrometry. This analysis established the presence of various compounds including fatty acids and notable levels of mercury, sulphur, aluminium, potassium, magnesium, nitrates and phosphorous. The contents and probable functions of the four vessels were characterised from the residues on these sherds as different from each other, reflecting their different decoration, manufacture and ceramic typologies. One of these vessels contains residue that indicate the vessel held oils. The residue of the second vessel is consistent with either scented materials or medicinal contents, while a third probably contained medicinal material. The unique fourth sherd is from a stoneware sphero-conical vessel with very thick walls, no decoration and the residue supports the possibility it was used for the storage of chemicals or may have held the chemical ingredients for an explosive device, consistent with a medieval grenade. This residue analysis of Mamluk sphero-conical vessels provides insight into luxury items, medicines, technology and trade in medieval Jerusalem.

Abstract Background The cost of new anticancer drugs is rising. We aimed to assess the clinical benefit and price of anti‐cancer drugs approved by the US Food and Drug Administration (FDA) for advanced gastrointestinal cancers. Methods Drugs approved between 2006 and 2017 for advanced GI malignancies were identified from FDA.gov, and their updated supporting trial data were searched. Incremental clinical benefit was quantified by using ESMO Magnitude of Clinical Benefit Scale version 1.1 (grade 0‐5) and ASCO Value Framework version 2 (score range −20 to 180). Higher scores indicate larger net benefit, and substantial benefit was defined as score 4 or 5 by the European Society for Medical Oncology (ESMO). The Micromedex REDBOOK was used to estimate the monthly average wholesale price (AWP) and total drug price (TDP) over the median treatment duration per patient. Clinical benefit, AWP and TDP of each drug class were assessed. Results In total, 16 GI cancer drugs received FDA approval for 24 indications, including five monoclonal antibodies (mAbs), five oral targeted therapies (TT), two immunotherapeutics (IO), three cytotoxic chemotherapies (CT), and one recombinant fusion protein (aflibercept). Most supporting trials (82%) reported overall survival benefit of less than 3 months and no significant improvement in quality of life. Only five agents (including one TT and one IO) with 21% the of approved indications met the ESMO's threshold of substantial clinical benefit. Median incremental benefit scores of TT and IO were comparable to other drug classes. However their median TDP was much higher at $153 402 and $98 208, respectively, compared to $30 330 USD per patient for CT. The estimated TDP did not correlate with clinical benefit scores. Conclusion Most FDA–approved gastrointestinal cancer drugs do not meet the ESMO threshold of substantial clinical benefit. TT and IO are estimated to carry significant drug costs, and further cost analysis of these drugs is urgently needed.

On May 5th, 1862, heavily outnumbered Mexican troops succeeded in defeating the invading French army at the Battle of Puebla. The battle did little to change the war’s outcome, but became a powerful symbol of Mexican national unity that helped to make sense of the violence of the previous decades. Celebrations to commemorate the Cinco de Mayo began almost as soon as the battle had ended, and have since evolved in Puebla to become one of the city’s pre-eminent expressions of civic identity. This article explores the evolution of the battle’s commemorations over a five-year period, during which the city invested in multiple new museums and tourist infrastructure connected to the iconic events. The article focuses on two key heritage precincts, containing six museums that were central to attempts to transform the historic city centre. The article explores how attempts to co-opt historic suffering was used to frame a narrative of civic democracy and inclusion. In so doing, it signals the role of state-level governments in curating a nationally significant memory. It also suggests a need for caution as government co-opts multiple stories into a means to augment its own authority.

Natural disturbances play important roles in the functioning and structure of lotic ecosystems, especially in small streams. Adaptation to natural disturbances, in the form of resilience, can be affected by anthropogenic disturbances such as urbanization and industrial zones, which in turn can limit stream biodiversity. The aim of this study was to assess the effects of runoff from urban and industrial zones on the resilience of benthic macroinvertebrate assemblages in small streams. For that, we tested the hypothesis that benthic macroinvertebrate assemblages in streams affected by urbanization and industrialization have lower resilience to natural disturbances than those in reference areas. We calculated the recovery proportions of Taxa Richness, Taxa Abundance, Resistant Taxa Richness, Resistant Taxa Abundance, Sensitive Taxa Richness and Sensitive Taxa Abundance. Recovery proportions of freshwater biodiversity were calculated as the target variable values during the dry season divided by the same variable in the previous rainy season. Taxa Richness recovery proportion and Sensitive Taxa Richness recovery proportion were significantly higher (p