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4 results on '"Robert E. Mehler"'

1. Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease

Author

Joseph Yang, Edward N. Brody, Ashwin C. Murthy, Robert E. Mehler, Sophie J. Weiss, Robert K. DeLisle, Rachel Ostroff, Stephen A. Williams, and Peter Ganz

Subjects
cardiovascular disease, chronic kidney disease, proteomics, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart disease from the Heart and Soul cohort, we quantified 1054 plasma proteins using modified aptamers (SOMAscan) to: (1) discern how reduced glomerular filtration influences the circulating proteome, (2) learn of the importance of kidney function to the prognostic information contained in recently identified protein cardiovascular risk biomarkers, and (3) identify novel and even unique cardiovascular risk biomarkers among individuals with CKD. Methods and Results Plasma protein levels were correlated to estimated glomerular filtration rate (eGFR) using Spearman‐rank correlation coefficients. Cox proportional hazard models were used to estimate the association between individual protein levels and the risk of the cardiovascular outcome (first among myocardial infarction, stroke, heart failure hospitalization, or mortality). Seven hundred and nine (67.3%) plasma proteins correlated with eGFR at P

Published
2020
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2. Driving forces in cancer diagnostics

Author

Todd R, Gander, Edward N, Brody, Robert E, Mehler, Joseph S, Heilig, Britta S, Singer, and Larry, Gold

Subjects
Education, Continuing, Clinical Laboratory Techniques, Neoplasms, Human Genome Project, Biomarkers, Tumor, Computational Biology, Humans, Enzyme-Linked Immunosorbent Assay, Genomics, United States, Neoplasm Proteins
Published
2003

3. How the Circulatory System Works

Author

Robert E. Mehler and Robert E. Mehler

Subjects
Cardiovascular system--Physiology, Blood--Circulation, Cardiovascular system
Abstract

This book includes 10 lectures in a light, entertaining style, with each'lecture'building on the previous one - making it easy for the reader to comprehend the vastly complicated functions of the circulatory system. The length of the text has intentionally been kept short; it is neither exhaustively complete nor over-simplified. It is enriched by details about basic biologic mechanisms and clever ways nature has solved a problem or achieved a result.

Published
2001

4. Influence of Antibiotics and Hemorrhage upon Serum Properdin Titers

Author

Robert E. Mehler, Benjamin Blattberg, Matthew N. Levy, and Phillip G. Banning

Subjects
Prior treatment, medicine.medical_specialty, Fecal flora, business.industry, medicine.drug_class, Antibiotics, Hemorrhagic hypotension, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Regimen, Titer, Internal medicine, Immunology, Medicine, Properdin, business, Survival rate
Abstract

ConclusionIn dogs subjected to a standard hemorrhagic hypotension. survival rate was significantly increased by prior treatment with antibiotics. This regimen eliminated typical E. coli, and markedly reduced the Gram–negative fecal flora. Seven of 8 of these survivors had significantly increased properdin titers following antibiotic administration. In a group of dogs treated with milk of magnesia, though the survival rate was not increased, the survivors all had significantly increased properdin titers. The pre–treatment properdin titers were not significantly related to subsequent survival from standard hemorrhagic hypotension.

Published
1961
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