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Verifying and validating explosion-resistant design models are challenging tasks due to the difficulties in accurately capturing the failure evolution within a setup influenced by the combined effects of fluid–solid interactions (FSI), blast waves, fragmentation, and impact. Curtain wall system, as a key structural component, is widely used in various types of buildings for its aesthetic appeal and weather protection. Hence, optimizing the explosion-resistance of such systems is necessary to improve building safety. In this work, we develop computational procedures that can be used to enhance the design of blast-resistant structures. This paper focuses on studying a representative component (e.g., window panels) from a typical curtain wall system, as well as a small-scale modeling of shock tube testing. For that, the material point method (MPM) simulations are verified against the finite element method (FEM) simulations, and the computational results are validated against shock tube testing. The work objective is to evaluate the simulation fidelity of explosion responses in several case studies. The first case study demonstrates how the MPM captures damage and fragmentation in a typical confined explosion event involving FSI, thus, providing an improved physical description compared to the FEM. The second case study qualitatively compares the MPM's ability to simulate the shock tube response with experimental observations. Since the second study validates that the MPM solution is qualitatively consistent with the experimental data, the MPM model is then used in the third case study to establish an FEM model that could capture the same physics. This FEM model can be scaled up to model field experiments. The fourth case study involves the development of an FEM model for a representative curtain wall system component, which is validated against experimental results and then scaled down and employed to validate a corresponding MPM model. The proposed procedure provides a feasible approach to verifying and validating explosion-resistant designs for more general cases. [ABSTRACT FROM AUTHOR]