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3. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000–2007: Results of EUROCARE-5 population-based study

Author

Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Zvolský, M., Dušek, L., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Troussard, X., Bouvier, V., Launoy, G., Guizard, A.V., Faivre, J., Bouvier, A.M., Arveux, P., Maynadié, M., Woronoff, A.S., Robaszkiewicz, M., Baldi, I., Monnereau, A., Tretarre, B., Bossard, N., Belot, A., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Meyer, M., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Kieschke, J., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mancuso, P., Ferretti, S., Crocetti, E., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Dal Maso, L., De Angelis, R., Caldora, M., Capocaccia, R., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Bonelli, L., Vercelli, M., Gennaro, V., Ricci, P., Autelitano, M., Randi, G., Ponz De Leon, M., Marchesi, C., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Traina, A., Staiti, R., Vitale, F., Ravazzolo, B., Michiara, M., Tumino, R., Giorgi Rossi, P., Di Felice, E., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Dei Tos, A.P., Guzzinati, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Gózdz, S., Mezyk, R., Blaszczyk, J., Bebenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Nicula, F., Coza, D., Safaei Diba, C., Primic-Zakelj, M., Almar, E., Ramírez, C., Errezola, M., Bidaurrazaga, J., Torrella-Ramos, A., Díaz García, J.M., Jimenez-Chillaron, R., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Chang, D.Y.L., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Lemmens, V., Coleman, M., Allemani, C., Rachet, B., Verne, J., Easey, N., Lawrence, G., Moran, T., Rashbass, J., Roche, M., Wilkinson, J., Gavin, A., Donnelly, C., Brewster, D.H., Huws, D.W., White, C., Otter, R., De Angelis, Roberta, Minicozzi, Pamela, Sant, Milena, Dal Maso, Luigino, Brewster, David H., Osca-Gelis, Gemma, Visser, Otto, Maynadié, Marc, Marcos-Gragera, Rafael, Troussard, Xavier, Agius, Dominic, Roazzi, Paolo, Meneghini, Elisabetta, and Monnereau, Alain

Published
2015
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4. The transcatheter aortic valve implantation: an assessment of the generalizability of the economic evidences following a systematic review

Author

Matteo Ruggeri, Mandolini Donatella, Campisi Federica, Danese Salvatore, Santori Costanza, Chiappetta Marta, Roazzi Paolo, and Marchetti Marco

Subjects
Transcatheter Aortic Valve Replacement, Health Policy, Cost-Benefit Analysis, Humans, Aortic Valve Stenosis
Abstract

Objectives Scientific literature debates on the economic affordability of transcatheter aortic valve implantation (TAVI) in order to give a useful support to decision makers aiming at establishing a reimbursement scheme for TAVI. For this reason, it is important to assess the quality and the generalizability of the existing economic evidences. Methods The first step was to run a literature search according to a predefined population, intervention, comparator, and outcome on the cost and effectiveness of the TAVI procedure in comparison to medical therapy and traditional surgery. Second, a manual search was carried out on the Web sites of the main HTA agencies. Third, the checklist developed by Augustovski et al. was applied in order to assess the quality and the generalizability of the articles resulting from the selection process. Results Overall, 106 articles were obtained. Of these, sixty-five articles were excluded since the title was not consistent with the objective. Further selection took place after abstract and full-text reading. In the end, thirty-one documents were included for the review. According to the checklist, none of the articles was considered generalizable and only one was considered transferable which compares the TAVI procedure with Medical Management in inoperable patients. Conclusions Despite the overall quality of the selected studies was considered good, there is still a lack of evidence on whether evidences generated in different contexts can be considered generalizable. Further research on resource consumption and preferences is needed in order to provide decision makers with more robust evidences.

Published
2022

6. Toolkit of instruments to identify the clinical variability and its impact on the use of health technology

Author

Ruggeri, Matteo, Marchetti, Marco, and Roazzi, Paolo

Subjects
efficiency frontiers, technical efficiency, clinical variation
Abstract

IMPACT HTA - WP8 developed a toolkit aimed at analysing the different factors (i.e. behaviour of healthcare professionals and organizational issues) further to the technical characteristic of technology that contribute to clinical variability. In particular, the toolkit mainly relies on an analytical tool aimed at assessing the clinical variation due to the use of health technologies, with a specific focus on the impact of clinical variation on the allocative and technical efficiency of hospitals. Such analytical tool allows to calculate either economic and technical efficiency gains deriving from: (1) policies aimed at reducing purchasing prices of medical devices or equipment, (2) organizational interventions aimed at reducing the resource used for operational surgeries (i.e. duration, health professionals involvement, …), and (3) interventions aimed at reducing administrative and hospitality costs.&nbsp

Published
2021
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8. Antibodies to neuronal surface proteins in Tourette Syndrome: Lack of evidence in a European paediatric cohort

Author

Anastasiou, Zacharias, Apter, Alan, Bartolini, Erika, Benaroya-Milshtein, Noa, Bodmer, Benjamin, Bognar, Emese, Burger, Bianka, Correa Vela, Marta, Creti, Roberta, Dietrich, Andrea, Debes, Nanette M., Efstratiou, Androulla, Cristina Ferro, Maria, Fremer, Carolin, Garcia-Delgar, Blanca, Gariup, Maria, Georgitsi, Marianthi, Gulisano, Mariangela, Hagen, Annelieke, Hagstrøm, Julie, Hedderly, Tammy J., Heyman, Isobel, Hoekstra, Pieter J., Huyser, Chaim, Imperi, Monica, Karagiannidis, Iordanis, Laviola, Giovanni, Macri, Simone, Madruga-Garrido, Marcos, Margarit, Immaculada, Marotta, Anna, Martino, Davide, Meier, Ute C., Mir, Pablo, Moll, Natalie, Morer, Astrid, Müller-Vahl, Kirsten, Münchau, Alexander, Nagy, Peter, Neri, Valeria, Openneer, Thaïra J.C., Orefici, Graziella, Paschou, Peristera, Pellico, Alessandra, Porcelli, Cesare, Redondo, Marina, Rizzo, Renata, Roazzi, Paolo, Roessner, Veit, Ruhrman, Daphna, Schnell, Jaana M.L., Schrag, Anette, Schütze, Gregor A., Schwarz, Markus J., Rosaria Silvestri, Paola, Skov, Liselotte, Steinberg, Tamar, Stöber, Sara, Tallon, Marco, Tarnok, Zsanett, Baglioni, V., Coutinho, E., Menassa, D.A., Giannoccaro, M.P., Jacobson, L., Buttiglione, M., Petruzzelli, O., Cardona, F., and Vincent, A.

Published
2019
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10. Clinical and Immunological Outcomes in High-Risk Resected Melanoma Patients Receiving Peptide-Based Vaccination and Interferon Alpha, With or Without Dacarbazine Preconditioning: A Phase II Study

Author

Urbani, Francesca, primary, Ferraresi, Virginia, additional, Capone, Imerio, additional, Macchia, Iole, additional, Palermo, Belinda, additional, Nuzzo, Carmen, additional, Torsello, Angela, additional, Pezzotti, Patrizio, additional, Giannarelli, Diana, additional, Pozzi, Anna Fausta, additional, Santaquilani, Mariano, additional, Roazzi, Paolo, additional, Bastucci, Silvia, additional, Catricalà, Caterina, additional, La Malfa, Antonia, additional, Vercillo, Giuseppe, additional, Gualtieri, Novella, additional, Buccione, Carla, additional, Castiello, Luciano, additional, Cognetti, Francesco, additional, Nisticò, Paola, additional, Belardelli, Filippo, additional, Moschella, Federica, additional, and Proietti, Enrico, additional

Published
2020
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11. Multi-Criteria-Decision-Analysis (MCDA) for the Horizon Scanning of Health Innovations an Application to COVID 19 Emergency

Author

Ruggeri, Matteo, Cadeddu, Chiara, Roazzi, Paolo, Mandolini, Donatella, Grigioni, Mauro, Marchetti, Marco, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), Marchetti, Marco (ORCID:0000-0002-8367-8268), Ruggeri, Matteo, Cadeddu, Chiara, Roazzi, Paolo, Mandolini, Donatella, Grigioni, Mauro, Marchetti, Marco, Cadeddu, Chiara (ORCID:0000-0003-0149-1078), and Marchetti, Marco (ORCID:0000-0002-8367-8268)

Abstract

Aim: In this article, we aim to present a tool for the early assessment of medical technologies. This evaluation system was designed and implemented by the National Centre for HTA and the National Centre for Innovative Technologies of the Istituto Superiore di Sanita, Italy, in order to respond to an institutional commitment within the "Health Technologies Assessment Team" that was established to face the huge demand for the evaluation of Health Technologies during the pandemic event caused by COVID-19, with a smart and easy-to-use framework. Methods: Horizon scanning was conducted through a brief assessment carried out according to the multicriteria decision analysis methodology. Each HTA domain was attributed a score according to a pros/cons and opportunities/threats system, derived from evidence in the literature. Scores were weighted according to different perspectives. Scores were presented in a Cartesian graph showing the positioning according to the potential value and the perceived risk associated with the technology. Results: Two case studies regarding the early assessment were reported, concerning two specific technologies: an individual protection device and a contact tracking system.

Published
2020

12. Antibodies to neuronal surface proteins in Tourette Syndrome: Lack of evidence in a European paediatric cohort

Author

Baglioni, V., primary, Coutinho, E., additional, Menassa, D.A., additional, Giannoccaro, M.P., additional, Jacobson, L., additional, Buttiglione, M., additional, Petruzzelli, O., additional, Cardona, F., additional, Vincent, A., additional, Anastasiou, Zacharias, additional, Apter, Alan, additional, Bartolini, Erika, additional, Benaroya-Milshtein, Noa, additional, Bodmer, Benjamin, additional, Bognar, Emese, additional, Burger, Bianka, additional, Correa Vela, Marta, additional, Creti, Roberta, additional, Dietrich, Andrea, additional, Debes, Nanette M., additional, Efstratiou, Androulla, additional, Cristina Ferro, Maria, additional, Fremer, Carolin, additional, Garcia-Delgar, Blanca, additional, Gariup, Maria, additional, Georgitsi, Marianthi, additional, Gulisano, Mariangela, additional, Hagen, Annelieke, additional, Hagstrøm, Julie, additional, Hedderly, Tammy J., additional, Heyman, Isobel, additional, Hoekstra, Pieter J., additional, Huyser, Chaim, additional, Imperi, Monica, additional, Karagiannidis, Iordanis, additional, Laviola, Giovanni, additional, Macri, Simone, additional, Madruga-Garrido, Marcos, additional, Margarit, Immaculada, additional, Marotta, Anna, additional, Martino, Davide, additional, Meier, Ute C., additional, Mir, Pablo, additional, Moll, Natalie, additional, Morer, Astrid, additional, Müller-Vahl, Kirsten, additional, Münchau, Alexander, additional, Nagy, Peter, additional, Neri, Valeria, additional, Openneer, Thaïra J.C., additional, Orefici, Graziella, additional, Paschou, Peristera, additional, Pellico, Alessandra, additional, Porcelli, Cesare, additional, Redondo, Marina, additional, Rizzo, Renata, additional, Roazzi, Paolo, additional, Roessner, Veit, additional, Ruhrman, Daphna, additional, Schnell, Jaana M.L., additional, Schrag, Anette, additional, Schütze, Gregor A., additional, Schwarz, Markus J., additional, Rosaria Silvestri, Paola, additional, Skov, Liselotte, additional, Steinberg, Tamar, additional, Stöber, Sara, additional, Tallon, Marco, additional, and Tarnok, Zsanett, additional

Published
2019
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13. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000–2007: Results of EUROCARE-5 population-based study

Author

De Angelis, Roberta, primary, Minicozzi, Pamela, additional, Sant, Milena, additional, Dal Maso, Luigino, additional, Brewster, David H., additional, Osca-Gelis, Gemma, additional, Visser, Otto, additional, Maynadié, Marc, additional, Marcos-Gragera, Rafael, additional, Troussard, Xavier, additional, Agius, Dominic, additional, Roazzi, Paolo, additional, Meneghini, Elisabetta, additional, Monnereau, Alain, additional, Hackl, M., additional, Zielonke, N., additional, Oberaigner, W., additional, Van Eycken, E., additional, Henau, K., additional, Valerianova, Z., additional, Dimitrova, N., additional, Sekerija, M., additional, Zvolský, M., additional, Dušek, L., additional, Storm, H., additional, Engholm, G., additional, Mägi, M., additional, Aareleid, T., additional, Malila, N., additional, Seppä, K., additional, Velten, M., additional, Troussard, X., additional, Bouvier, V., additional, Launoy, G., additional, Guizard, A.V., additional, Faivre, J., additional, Bouvier, A.M., additional, Arveux, P., additional, Maynadié, M., additional, Woronoff, A.S., additional, Robaszkiewicz, M., additional, Baldi, I., additional, Monnereau, A., additional, Tretarre, B., additional, Bossard, N., additional, Belot, A., additional, Colonna, M., additional, Molinié, F., additional, Bara, S., additional, Schvartz, C., additional, Lapôtre-Ledoux, B., additional, Grosclaude, P., additional, Meyer, M., additional, Stabenow, R., additional, Luttmann, S., additional, Eberle, A., additional, Brenner, H., additional, Nennecke, A., additional, Engel, J., additional, Schubert-Fritschle, G., additional, Kieschke, J., additional, Heidrich, J., additional, Holleczek, B., additional, Katalinic, A., additional, Jónasson, J.G., additional, Tryggvadóttir, L., additional, Comber, H., additional, Mazzoleni, G., additional, Bulatko, A., additional, Buzzoni, C., additional, Giacomin, A., additional, Sutera Sardo, A., additional, Mancuso, P., additional, Ferretti, S., additional, Crocetti, E., additional, Caldarella, A., additional, Gatta, G., additional, Sant, M., additional, Amash, H., additional, Amati, C., additional, Baili, P., additional, Berrino, F., additional, Bonfarnuzzo, S., additional, Botta, L., additional, Di Salvo, F., additional, Foschi, R., additional, Margutti, C., additional, Meneghini, E., additional, Minicozzi, P., additional, Trama, A., additional, Serraino, D., additional, Dal Maso, L., additional, De Angelis, R., additional, Caldora, M., additional, Capocaccia, R., additional, Carrani, E., additional, Francisci, S., additional, Mallone, S., additional, Pierannunzio, D., additional, Roazzi, P., additional, Rossi, S., additional, Santaquilani, M., additional, Tavilla, A., additional, Pannozzo, F., additional, Busco, S., additional, Bonelli, L., additional, Vercelli, M., additional, Gennaro, V., additional, Ricci, P., additional, Autelitano, M., additional, Randi, G., additional, Ponz De Leon, M., additional, Marchesi, C., additional, Cirilli, C., additional, Fusco, M., additional, Vitale, M.F., additional, Usala, M., additional, Traina, A., additional, Staiti, R., additional, Vitale, F., additional, Ravazzolo, B., additional, Michiara, M., additional, Tumino, R., additional, Giorgi Rossi, P., additional, Di Felice, E., additional, Falcini, F., additional, Iannelli, A., additional, Sechi, O., additional, Cesaraccio, R., additional, Piffer, S., additional, Madeddu, A., additional, Tisano, F., additional, Maspero, S., additional, Fanetti, A.C., additional, Zanetti, R., additional, Rosso, S., additional, Candela, P., additional, Scuderi, T., additional, Stracci, F., additional, Bianconi, F., additional, Tagliabue, G., additional, Contiero, P., additional, Dei Tos, A.P., additional, Guzzinati, S., additional, Pildava, S., additional, Smailyte, G., additional, Calleja, N., additional, Agius, D., additional, Johannesen, T.B., additional, Rachtan, J., additional, Gózdz, S., additional, Mezyk, R., additional, Blaszczyk, J., additional, Bebenek, M., additional, Bielska-Lasota, M., additional, Forjaz de Lacerda, G., additional, Bento, M.J., additional, Castro, C., additional, Miranda, A., additional, Mayer-da-Silva, A., additional, Nicula, F., additional, Coza, D., additional, Safaei Diba, C., additional, Primic-Zakelj, M., additional, Almar, E., additional, Ramírez, C., additional, Errezola, M., additional, Bidaurrazaga, J., additional, Torrella-Ramos, A., additional, Díaz García, J.M., additional, Jimenez-Chillaron, R., additional, Marcos-Gragera, R., additional, Izquierdo Font, A., additional, Sanchez, M.J., additional, Chang, D.Y.L., additional, Navarro, C., additional, Chirlaque, M.D., additional, Moreno-Iribas, C., additional, Ardanaz, E., additional, Galceran, J., additional, Carulla, M., additional, Lambe, M., additional, Khan, S., additional, Mousavi, M., additional, Bouchardy, C., additional, Usel, M., additional, Ess, S.M., additional, Frick, H., additional, Lorez, M., additional, Herrmann, C., additional, Bordoni, A., additional, Spitale, A., additional, Konzelmann, I., additional, Visser, O., additional, Lemmens, V., additional, Coleman, M., additional, Allemani, C., additional, Rachet, B., additional, Verne, J., additional, Easey, N., additional, Lawrence, G., additional, Moran, T., additional, Rashbass, J., additional, Roche, M., additional, Wilkinson, J., additional, Gavin, A., additional, Donnelly, C., additional, Brewster, D.H., additional, Huws, D.W., additional, White, C., additional, and Otter, R., additional

Published
2015
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14. Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP) : association between lipid profile and socio-demographic variables

Author

Napolitano, Mariarosaria, Santoro, Filippo, Puopolo, Maria, Donfancesco, Chiara, Galluzzo, Lucia, De Grandi, Alessandro, Cevenini, Elisa, De Curtis, Amalia, Sevini, Federica, Palmieri, Luigi, Mascalzoni, Deborah, Roazzi, Paolo, Scafato, Emanuele, Pramstaller, Peter, Iacoviello, Licia, Donati, Maria B, Giampaoli, Simona, Franceschi, Claudio, Belardelli, Filippo, Bravo, Elena, Napolitano, Mariarosaria, Santoro, Filippo, Puopolo, Maria, Donfancesco, Chiara, Galluzzo, Lucia, De Grandi, Alessandro, Cevenini, Elisa, De Curtis, Amalia, Sevini, Federica, Palmieri, Luigi, Mascalzoni, Deborah, Roazzi, Paolo, Scafato, Emanuele, Pramstaller, Peter, Iacoviello, Licia, Donati, Maria B, Giampaoli, Simona, Franceschi, Claudio, Belardelli, Filippo, and Bravo, Elena

Abstract

The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With the aim of overcoming these difficulties and establishing the "proof-of-concept" that sharing studies is achievable among Italian collections, a data-sharing pilot project has been agreed to by HIBP members. Participants agreed to the general methodology and signed a shared Data Transfer Agreement. The biobanks involved were: EURAC (Micros study), CIG (GEHA project), CNESPS (FINE, MATISS, MONICA, OEC1998, ITR (Italian Twin Register), and IPREA studies, and MOLIBANK (Moli-Sani project). Biobank data were uploaded into a common database using a dedicated informatics infrastructure. Demographic data, and anthropometric and hematochemical parameters were shared for each record. Each biobank uploaded into the common database a dataset with a minimum of 1000 subjects, for a total of 5071 records. After a harmonization process, the final dataset included 3882 records. Subjects were grouped into three main geographic areas of Italy (North, Center, and South) and separate analyses were performed for men and women. The 3882 records were analyzed through multivariate logistic regression analysis. Results were expressed as odds ratios with 95% confidence interval. Results show several geographical differences in the lipidemic pattern, mostly regarding cholesterol-HDL, which represents a strong basis for further, deeper sample-based studies. This HIBP pilot study aimed to prove the feasibility of such collaborations and it provides a methodological prototype for future studies based on the participation in the partnership of well-established quality collections.

Published
2014
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15. Development of a Pilot Project on Data Sharing among Partners of the Italian Hub of Population Biobanks (HIBP): Association between Lipid Profile and Socio-Demographic Variables

Author

Napolitano, Mariarosaria, primary, Santoro, Filippo, additional, Puopolo, Maria, additional, Donfancesco, Chiara, additional, Galluzzo, Lucia, additional, De Grandi, Alessandro, additional, Cevenini, Elisa, additional, De Curtis, Amalia, additional, Sevini, Federica, additional, Palmieri, Luigi, additional, Mascalzon, Deborah, additional, Roazzi, Paolo, additional, Scafato, Emanuele, additional, Pramstaller, Peter, additional, Iacoviello, Licia, additional, Donati, Maria B., additional, Giampaoli, Simona, additional, Franceschi, Claudio, additional, Belardelli, Filippo, additional, and Bravo, Elena, additional

Published
2014
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17. The ISS Reclamation Data Bank.

Author

Musmeci L, Bellino M, Binetti R, Ceccarelli F, Costamagna FM, D'Angiolini A, Fabri A, Falleni F, Ferri M, Piccardi A, Roazzi P, Trucchi D, and Marcello I

Subjects
Carcinogens, Environmental adverse effects, Environmental Exposure adverse effects, Environmental Exposure analysis, Europe, Hazardous Substances adverse effects, Humans, Italy, Models, Theoretical, Neoplasms chemically induced, Neoplasms prevention & control, Practice Guidelines as Topic, United States, Databases, Factual, Public Health, Soil standards, Water standards
Abstract

Since the issue of the first regulations concerning the remediation of contaminated sites, the Istituto Superiore di Sanità, on the basis of specific requests, has drawn up various technical opinions regarding the proposed reference values (quality standards) for soils and underground waters, to be achieved when remediating contaminated sites, for substances for which no standard limit values did not exist at that time. These reference values, widely used throughout the country and accepted and adopted as "remediation aim" values by various territorial bodies responsible for the approval and monitoring of remediation projects, have been collected in a specific reclamation oriented data bank known as the "Banca Dati Bonifiche (BDB)" (Reclamation Data Bank). The BDB contains the related standardized "rationale" for each reference value, in order to serve as a useful reference for the national bodies concerned with the remediation of contaminated sites.

Published
2008

18. The ISS Sensitizing Agents Data Bank (BDS).

Author

Brunetto B, Binetti R, Ceccarelli F, Costamagna FM, D'Angiolini A, Fabri A, Ferri M, Marcello I, Riva G, Roazzi P, Trucchi D, and Tinghino R

Subjects
Allergens classification, European Union, Food Hypersensitivity etiology, Hazardous Substances adverse effects, Humans, Hypersensitivity prevention & control, Internet, Italy, Allergens adverse effects, Databases, Factual, Hypersensitivity etiology, Public Health
Abstract

The Istituto Superiore Sanità has developed a data bank on sensitizing substances (Banca Dati Sensibilizzanti, BDS), available on website (www.iss.it/bdse/), sharing complete, controlled and updated information coming from different sources, such as scientific publications, international agencies and governmental or non governmental organizations. It is worthwhile that the main objective of the BDS is not the classification of sensitizing or potentially sensitizing agents within specific risk classes, but it is essentially to provide concise and non confidential information related to this endpoint. At present, the BDS includes: all the substances officially classified by European Union, (Annex I to Directive 67/548/EEC), some substances listed in I (Directive 67/548/EEC) for endpoints different than "sensitization" but indicated as sensitizers by other relevant institutions, all the substances indicated as sensitizers by relevant agencies or institutions (ACGIH, DFG), some substances indicted as sensitizers by industry and other non-governmental organizations (ETAD and HERA), all the substances regarded as "potentially sensitizing dyes" by the Commission of the European Community for the award of the eco-label to textile products, some substances for which, even in the absence of any categorization by Union, ACGIH or DFG, it is not possible to exclude a sensitizing potential on the basis of reliable documents.

Published
2008

19. The ISS Carcinogens Data Bank (BDC).

Author

Binetti R, Ceccarelli F, Costamagna FM, D'Angiolini A, Fabri A, Ferri M, Riva G, Roazzi P, Trucchi D, and Marcello I

Subjects
European Union, Humans, Information Services organization & administration, Italy, Occupational Diseases chemically induced, Risk Assessment, Risk Factors, Carcinogens, Environmental classification, Carcinogens, Environmental toxicity, Databases, Factual standards, Occupational Diseases prevention & control, Public Health standards
Abstract

The Data Bank on Carcinogens (Banca Dati Cancerogeni, BDC) is a factual data bank, available on the Istituto Superiore di Sanità website, aimed at supporting the risk management decision making of central and local administrators. It can also represent a valuable tool for industry. The available information on carcinogenicity evaluations/classifications produced by European Union and by other institutions (IARC, USEPA, NTP, CCTN) is presented in a concise form accompanied by bibliographic references enabling the users to consult the original sources and, in some cases, to be directly connected to the relevant website. The classifications carried out by each organization in accordance with its own criteria assign the examined agents to specific qualitative categories and do not include quantitative assessment. BDC intends to provide an easy tool for experts, researchers and risk managers dealing with carcinogenic agents.

Published
2008

20. Surveillance of toxic exposures: the pilot experience of the Poison Control Centers of Milan, Pavia and Bergamo in 2006.

Author

Settimi L, Davanzo F, Carbone P, Sesana F, Locatelli C, Farina ML, Maiozzi P, Roazzi P, Maccari F, Macchi L, and Fanuzzi A

Subjects
Adolescent, Adult, Agrochemicals poisoning, Child, Child, Preschool, Cosmetics poisoning, Drug-Related Side Effects and Adverse Reactions, Foodborne Diseases epidemiology, Household Products poisoning, Humans, Illicit Drugs poisoning, Incidence, Infant, Italy epidemiology, Pilot Projects, Play and Playthings, Population Surveillance, Poison Control Centers statistics & numerical data, Poisoning epidemiology
Abstract

Between 1 February and 31 March 2006, the Poison Control Centers (PPC) active in Lombardy collaborated with an integrated surveillance system carried out in Piedmont during the Olympic Games 2006. The collaborating PPC notified to the system 697 human cases of exposure occurred in Piedmont during the observation period. Among these cases, 70% were exposed accidentally, 40% were 6 years old or younger, and 45% reported at least a clinical effect. The agents more frequently reported were: cleaning substances (household) (110 cases), fumes/gases/vapors (63 cases, comprising 38 cases accidentally exposed to carbon monoxide), and sedative/hypnotics/antipsychotics (53 cases). Although very limited, the available observations focused the attention on specific hazards and were able to highlight the potential of a toxic exposure surveillance system based on the information reported by the Italian PPC.

Published
2007

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