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3. Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy

Author

Barnes, Eleanor, Matthews, Philippa C., Gelson, William, Cooke, Graham S., Khakoo, Salim I., Nastouli, Eleni, Davies, Jim, Woods, Kerrie, Stockdale, Alexander J., Ryder, Stephen, Elsharkawy, Ahmed, Easom, Nicholas, Bernal, William, Ahmad, Shazaad, Macdonald, Douglas, Wang, Tingyan, Campbell, Cori, Stanworth, Simon, Maynard, Suzanne, Roadknight, Gail, Little, Stephanie, Várnai, Kinga A., Glampson, Ben, Papadimitriou, Dimitri, Mercuri, Luca, Jones, Christopher R., Jaworski, Jakub, Davis, Cai, Borca, Florina, Heinson, Ashley, George, Michael, MacNaughton, Heidi, Kim, Yun, Meneses, Josune Olza, English, Louise, Roberts, Timothy, Romão, Luis, Ramlakhan, David, Todd, Stacy, Rogers, Heather, McIntyre, Karl, Frankland, Andrew, Salih, Hizni, Noble, Theresa, Roberts, Lara, Higgins, Finola, Vilar, Javier, Norris, Ruth, Tilston, George, Serafimova, Ilina, Montague, Sarah, Verheyden, Juliette, Juurlink, Irene, Jack, Kathryn, Waldren-Glenn, Alex, Poole, Lizzie, Day, Victoria, Reglar, Berit, Mayer, Erik, and Heinson, Ashley I.

Published
2025
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4. TOP-417 Machine learning can improve prediction of hepatitis B surface antigen seroclearance: A large multicentre cohort study in the United Kingdom

Author

Wang, Tingyan, primary, Jaworski, Jakub, additional, Glampson, Ben, additional, Papadimitriou, Dimitri, additional, Mercuri, Luca, additional, Jones, Christopher R., additional, Todd, Stacy, additional, McIntyre, Karl, additional, Frankland, Andrew, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Noble, Theresa, additional, Várnai, Kinga A., additional, Campbell, Cori, additional, Davis, Cai, additional, Heinson, Ashley I., additional, George, Michael, additional, Borca, Florina, additional, English, Louise, additional, Romão, Luis, additional, Ramlakhan, David, additional, Frisby, William, additional, Taylor, John, additional, Woods, Kerrie, additional, Davies, Jim, additional, Nastouli, Eleni, additional, Khakoo, Salim I., additional, Stockdale, Alexander J., additional, Easom, Nicholas, additional, Cooke, Graham S., additional, Gelson, William, additional, Matthews, Philippa C., additional, and Barnes, Eleanor, additional

Published
2024
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5. WED-471 Retrospective analysis of longitudinal data for UK adults living with chronic HBV: characteristics of the population on dual therapy

Author

Tan, Cedric, primary, Wang, Tingyan, additional, Jaworski, Jakub, additional, Glampson, Ben, additional, Papadimitriou, Dimitri, additional, Mercuri, Luca, additional, Jones, Christopher R, additional, Todd, Stacy, additional, McIntyre, Karl, additional, Frankland, Andrew, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Noble, Theresa, additional, AVárnai, Kinga, additional, Campbell, Cori, additional, Davis, Cai, additional, Heinson, Ashley I, additional, George, Michael, additional, Borca, Florina, additional, English, Louise, additional, Romão, Luis, additional, Ramlakhan, David, additional, Frisby, William, additional, Taylor, John, additional, Woods, Kerrie, additional, Davies, Jim, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Stockdale, Alexander J, additional, Easom, Nicholas, additional, Cooke, Graham S, additional, Gelson, William, additional, Barnes, Eleanor, additional, and CMatthews, Philippa, additional

Published
2024
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6. Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data

Author

Chammas, Lara, primary, Yuan, Kevin, additional, Little, Stephanie, additional, Roadknight, Gail, additional, Varnai, Kinga A., additional, Chang, Shing Chan, additional, Sze, Shirley, additional, Davies, Jim, additional, Tsui, Andrew, additional, Salih, Hizni, additional, Glampson, Ben, additional, Papadimitriou, Dimitri, additional, Mulla, Abdulrahim, additional, Woods, Kerrie, additional, O’Gallagher, Kevin, additional, Shah, Anoop D., additional, Williams, Bryan, additional, Asselbergs, Folkert W., additional, Mayer, Erik, additional, Lee, Richard, additional, Herbert, Christopher, additional, Johnson, Tom, additional, Grant, Stuart, additional, Curzen, Nick, additional, Shah, Ajay M., additional, Perera, Divaka, additional, Patel, Riyaz S., additional, Channon, Keith M., additional, Kaura, Amit, additional, Mayet, Jamil, additional, Eyre, David W., additional, Squire, Iain, additional, Kharbanda, Raj, additional, Lewis, Andrew, additional, and Wijesurendra, Rohan S., additional

Published
2024
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7. Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Author

Campbell, Cori, primary, Wang, Tingyan, additional, Smith, David A., additional, Freeman, Oliver, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique I., additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I., additional, Gelson, William, additional, Cooke, Graham S., additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C., additional

Published
2023
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8. Distinct virologic trajectories in chronic hepatitis B patients identify heterogeneity in response to nucleotide analogue therapy

Author

Wang, Tingyan, primary, Campbell, Cori, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Stockdale, Alexander, additional, Todd, Stacy, additional, McIntyre, Karl, additional, Frankland, Andrew, additional, Jaworski, Jakub, additional, Chaudhry, Afzal, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R., additional, Varnai, Kinga, additional, Noble, Theresa, additional, Salih, Hizni, additional, Davis, Cai, additional, Heinson, Ashley, additional, George, Michael, additional, Borca, Florina, additional, Olza, Josune, additional, English, Louise, additional, Romão, Luis, additional, Ramlakhan, David, additional, Nastouli, Eleni, additional, Khakoo, Salim, additional, Gelson, Will, additional, Cooke, Graham, additional, Woods, Kerrie, additional, Davies, Jim, additional, Matthews, Philippa, additional, and Barnes, Eleanor, additional

Published
2023
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10. Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset

Author

Wang, Tingyan, primary, Smith, David A, additional, Campbell, Cori, additional, Freeman, Oliver, additional, Moysova, Zuzana, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique, additional, Collier, Jane, additional, Stockdale, Alexander J, additional, Todd, Stacy, additional, McIntyre, Karl, additional, Frankland, Andrew, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Gelson, William, additional, Cooke, Graham S, additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2022
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11. Establishing a colorectal cancer research database from routinely collected health data: the process and potential from a pilot study

Author

Tamm, Andres, primary, Jones, Helen JS, additional, Perry, William, additional, Campbell, Des, additional, Carten, Rachel, additional, Davies, Jim, additional, Galdikas, Algirdas, additional, English, Louise, additional, Garbett, Alex, additional, Glampson, Ben, additional, Harris, Steve, additional, Khan, Khurum, additional, Little, Stephanie, additional, Malcomson, Lee, additional, Matharu, Sheila, additional, Mayer, Erik, additional, Mercuri, Luca, additional, Morris, Eva JA, additional, Muirhead, Rebecca, additional, Norris, Ruth, additional, O’Hara, Catherine, additional, Papadimitriou, Dimitri, additional, Peek, Niels, additional, Renehan, Andrew, additional, Roadknight, Gail, additional, Starling, Naureen, additional, Teare, Marion, additional, Turner, Rachel, additional, Várnai, Kinga A, additional, Wasan, Harpreet, additional, Woods, Kerrie, additional, and Cunningham, Chris, additional

Published
2022
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12. Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Author

Campbell, Cori, primary, Wang, Tingyan, additional, Smith, David A., additional, Freeman, Oliver, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique I., additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I., additional, Gelson, William, additional, Cooke, Graham S., additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C., additional

Published
2022
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13. Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset.

Author

Wang, Tingyan, Smith, David A, Campbell, Cori, Freeman, Oliver, Moysova, Zuzana, Noble, Theresa, Várnai, Kinga A, Harris, Steve, Salih, Hizni, Roadknight, Gail, Little, Stephanie, Glampson, Ben, Mercuri, Luca, Papadimitriou, Dimitri, Jones, Christopher R, Taylor, Vince, Chaudhry, Afzal, Phan, Hang, Borca, Florina, and Olza, Josune

Subjects
MEDICAL informatics, HEPATITIS B virus, HEPATITIS D, RESEARCH institutes, HEPATITIS associated antigen, PLANT viruses
Abstract

To avoid submitting duplication of records to the lead centre, each Trust is responsible for locally maintaining a link between the patient's local identifier and the anonymous study identifier used in the dataset.[14] The central data repository is based on a secure data access platform and only authorized personnel are permitted to access data. Key Features The National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) has established a cohort of individuals with chronic hepatitis B virus (HBV) infection in secondary care in the UK, providing a resource for translational research. We are unable to capture the retrospective data that might be stored in a different Trust for patients even when data from this Trust are added into the dataset, as it is not possible to map patients between Trusts within the dataset due to anonymization. The exclusion criteria were: (i) patients without records of demographics or (ii) patients without mandated laboratory data (Supplementary Tables S2, S3, available as Supplementary data at I IJE i online) in the EPR systems (Supplementary Figure S1, available as Supplementary data at I IJE i online). [Extracted from the article]

Published
2023
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14. Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK

Author

Campbell, Cori, primary, Wang, Tingyan, additional, Smith, David A, additional, Freeman, Oliver, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique I., additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Gelson, William, additional, Cooke, Graham S, additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2021
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15. Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset

Author

Wang, Tingyan, primary, Smith, David A, additional, Campbell, Cori, additional, Freeman, Oliver, additional, Moysova, Zuzana, additional, Noble, Theresa, additional, Várnai, Kinga A, additional, Harris, Steve, additional, Salih, Hizni, additional, Roadknight, Gail, additional, Little, Stephanie, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Papadimitriou, Dimitri, additional, Jones, Christopher R, additional, Taylor, Vince, additional, Chaudhry, Afzal, additional, Phan, Hang, additional, Borca, Florina, additional, Olza, Josune, additional, Warricker, Frazer, additional, Romão, Luis, additional, Ramlakhan, David, additional, English, Louise, additional, Klenerman, Paul, additional, Andersson, Monique, additional, Collier, Jane, additional, Nastouli, Eleni, additional, Khakoo, Salim I, additional, Gelson, William, additional, Cooke, Graham S, additional, Woods, Kerrie, additional, Davies, Jim, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2021
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16. WED-137 - Distinct virologic trajectories in chronic hepatitis B patients identify heterogeneity in response to nucleotide analogue therapy

Author

Wang, Tingyan, Campbell, Cori, Roadknight, Gail, Little, Stephanie, Stockdale, Alexander, Todd, Stacy, McIntyre, Karl, Frankland, Andrew, Jaworski, Jakub, Chaudhry, Afzal, Glampson, Ben, Mercuri, Luca, Papadimitriou, Dimitri, Jones, Christopher R., Varnai, Kinga, Noble, Theresa, Salih, Hizni, Davis, Cai, Heinson, Ashley, George, Michael, Borca, Florina, Olza, Josune, English, Louise, Romão, Luis, Ramlakhan, David, Nastouli, Eleni, Khakoo, Salim, Gelson, Will, Cooke, Graham, Woods, Kerrie, Davies, Jim, Matthews, Philippa, and Barnes, Eleanor

Published
2023
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17. Establishing a colorectal cancer research database from routinely collected health data: the process and potential from a pilot study.

Author

Tamm A, Jones HJ, Perry W, Campbell D, Carten R, Davies J, Galdikas A, English L, Garbett A, Glampson B, Harris S, Khan K, Little S, Malcomson L, Matharu S, Mayer E, Mercuri L, Morris EJ, Muirhead R, Norris R, O'Hara C, Papadimitriou D, Peek N, Renehan A, Roadknight G, Starling N, Teare M, Turner R, Várnai KA, Wasan H, Woods K, and Cunningham C

Subjects
Humans, Information Storage and Retrieval, Natural Language Processing, Pilot Projects, Colorectal Neoplasms therapy, Electronic Health Records
Abstract

Objective: Colorectal cancer is a common cause of death and morbidity. A significant amount of data are routinely collected during patient treatment, but they are not generally available for research. The National Institute for Health Research Health Informatics Collaborative in the UK is developing infrastructure to enable routinely collected data to be used for collaborative, cross-centre research. This paper presents an overview of the process for collating colorectal cancer data and explores the potential of using this data source., Methods: Clinical data were collected from three pilot Trusts, standardised and collated. Not all data were collected in a readily extractable format for research. Natural language processing (NLP) was used to extract relevant information from pseudonymised imaging and histopathology reports. Combining data from many sources allowed reconstruction of longitudinal histories for each patient that could be presented graphically., Results: Three pilot Trusts submitted data, covering 12 903 patients with a diagnosis of colorectal cancer since 2012, with NLP implemented for 4150 patients. Timelines showing individual patient longitudinal history can be grouped into common treatment patterns, visually presenting clusters and outliers for analysis. Difficulties and gaps in data sources have been identified and addressed., Discussion: Algorithms for analysing routinely collected data from a wide range of sites and sources have been developed and refined to provide a rich data set that will be used to better understand the natural history, treatment variation and optimal management of colorectal cancer., Conclusion: The data set has great potential to facilitate research into colorectal cancer., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2022
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