Search

Your search keyword '"Rjabovs, Vitālijs"' showing total 30 results
Start Over Author "Rjabovs, Vitālijs"
30 results on '"Rjabovs, Vitālijs"'

28. Synthesis of novel 3-deoxy-3-C-triazolylmethyl-allose derivatives and evaluation of their biological activity.

Author

Rjabova, Jekaterina, Rjabovs, Vitālijs, Moreno Vargas, Antonio, Clavijo, Elena, and Turks, Māris

Abstract

Recently, monosaccharide-triazole conjugates have proved to possess a large variety of useful biological activities. This paper describes synthesis of a new series of 3-deoxy-3- C-triazolylmethyl-allose derivatives. These new compounds are obtained from acetonide-protected 3-deoxy-3-azidomethyl allose and commercial alkynes via Cu(I) catalyzed 1,3-dipolar cycloaddition. The obtained molecular scaffolds differ from those described earlier by the presence of a methylene linker (-CH-) between the C(3) of allose and the triazole moiety. It was demonstrated that acetonide-protected monosaccharide, 3-deoxy-3- C-(4-phenyl-1 H-1,2,3-triazol-1-yl)methyl-1,2:5,6-di- O-isopropylidene-α-d-allofuranose, inhibited α-L-fucosidase for 26% at 0.1 mM concentration, but a deprotected analog, 3-deoxy-3- C-(4-(4- tert-butylphenyl)-1 H-1,2,3-triazol-1-yl)methyl-β-d-allofuranose, showed 15% inhibition of β-glucosidase at 1 mM concentration. [InlineMediaObject not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

29. Crystal structure of 3-de-oxy-3-nitro-methyl-1,2;5,6-di-O-iso-propyl-idene-α-d-allo-furan-ose.

Author

Lugiņina J, Rjabovs V, and Stepanovs D

Abstract

The title compound, C13H21NO7 {systematic name: (3aR,5S,6R,6aR)-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-6-(nitro-meth-yl)tetra-hydro-furo[2,3-d][1,3]dioxole}, consists of a substituted 2,2-di-methyl-tetra-hydro-furo[2,3-d][1,3]dioxolane skeleton. The furan-ose ring A adopts a (o)T 4 conformation. The fused dioxolane ring B and the substituent dioxolane ring C also have twisted conformations. There are no strong hydrogen bonds in the crystal structure: only weak C-H⋯O contacts are present, which link the mol-ecules to form a three-dimensional structure.

Published
2016
Full Text
View/download PDF

30. {(3aR,5S,6R,6aR)-5-[(R)-1,2-Di-hydroxy-eth-yl]-2,2-di-methyl-tetra-hydro-furo[2,3-d][1,3]dioxol-6-yl}methyl methane-sulfonate.

Author

Rjabovs V, Mishnev A, Kiselovs G, and Turks M

Abstract

In the title compound, C11H20O8S, the furan-ose ring has a pseudorotation phase angle equal to 31.3° and assumes a (3) T 4 conformation, with deviations of 0.297 (4) and -0.152 (4) Å for the corresponding C atoms. The dioxolane ring adopts an envelope conformation. One of the O atoms is at the flap and deviates from the least-squares plane formed by the other four ring atoms by 0.405 (2) Å. The dihedral angle between the planar fragments of the rings is 63.53 (8)°. In the crystal, mol-ecules are associated into sheets perpendiculer to the b axis by means of O-H⋯O hydrogen bonds. A few weak C-H⋯O inter-actions are also observed.

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results