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16 results on '"Rizzo, Paola Chiara"'

5. Pre-Implantation Kidney Biopsies in Extended Criteria Donors: From On Call to Expert Pathologist, from Conventional Microscope to Digital Pathology

Author

Marletta, S, Di Bella, C, Catalano, G, Mastrosimini, M, Becker, J, Ernst, A, Rizzo, P, Caldonazzi, N, Vasuri, F, Malvi, D, Fanelli, G, Naccarato, G, Ghimenton, C, L'Imperio, V, Mescoli, C, Eccher, A, Furian, L, Pagni, F, Marletta, Stefano, Di Bella, Caterina, Catalano, Giovanni, Mastrosimini, Maria Gaia, Becker, Jan, Ernst, Angela, Rizzo, Paola Chiara, Caldonazzi, Nicolo, Vasuri, Francesco, Malvi, Deborah, Fanelli, Giuseppe Nicolo, Naccarato, Giuseppe, Ghimenton, Claudio, L'Imperio, Vincenzo, Mescoli, Claudia, Eccher, Albino, Furian, Lucrezia, Pagni, Fabio, Marletta, S, Di Bella, C, Catalano, G, Mastrosimini, M, Becker, J, Ernst, A, Rizzo, P, Caldonazzi, N, Vasuri, F, Malvi, D, Fanelli, G, Naccarato, G, Ghimenton, C, L'Imperio, V, Mescoli, C, Eccher, A, Furian, L, Pagni, F, Marletta, Stefano, Di Bella, Caterina, Catalano, Giovanni, Mastrosimini, Maria Gaia, Becker, Jan, Ernst, Angela, Rizzo, Paola Chiara, Caldonazzi, Nicolo, Vasuri, Francesco, Malvi, Deborah, Fanelli, Giuseppe Nicolo, Naccarato, Giuseppe, Ghimenton, Claudio, L'Imperio, Vincenzo, Mescoli, Claudia, Eccher, Albino, Furian, Lucrezia, and Pagni, Fabio

Abstract

The number of patients awaiting a kidney transplant is constantly rising but lack of organs leads kidneys from extended criteria donors (ECD) to be used to increase the donor pool. Pre-transplant biopsies are routinely evaluated through the Karpinski-Remuzzi score but consensus on its correlation with graft survival is controversial. This study aims to test a new diagnostic model relying on digital pathology to evaluate pre-transplant biopsies and to correlate it with graft outcomes. Pre-transplant biopsies from 78 ECD utilized as single kidney transplantation were scanned, converted to whole-slide images (WSIs), and reassessed by two expert nephropathologists using the Remuzzi-Karpinski score. The correlation between graft survival at 36 months median follow-up and parameters assigned by either WSI or glass slide score (GSL) by on-call pathologists was evaluated, as well as the agreement between the GSL and the WSIs score. No relation was found between the GSL assessed by on-call pathologists and graft survival (P = 0.413). Conversely, the WSI score assigned by the two nephropathologists strongly correlated with graft loss probability, as confirmed by the ROC curves analysis (DeLong test P = 0.046). Digital pathology allows to share expertise in the transplant urgent setting, ensuring higher accuracy and favoring standardization of the process. Its employment may significantly increase the predictive capability of the pre-transplant biopsy evaluation for ECD, improving the quality of allocation and patient safety.

Published
2023

6. Value of Artificial Intelligence in Evaluating Lymph Node Metastases

Author

Caldonazzi, Nicolò, primary, Rizzo, Paola Chiara, additional, Eccher, Albino, additional, Girolami, Ilaria, additional, Fanelli, Giuseppe Nicolò, additional, Naccarato, Antonio Giuseppe, additional, Bonizzi, Giuseppina, additional, Fusco, Nicola, additional, d’Amati, Giulia, additional, Scarpa, Aldo, additional, Pantanowitz, Liron, additional, and Marletta, Stefano, additional

Published
2023
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7. Pre-Implantation Kidney Biopsies in Extended Criteria Donors: From On Call to Expert Pathologist, from Conventional Microscope to Digital Pathology

Author

Marletta, Stefano, primary, Di Bella, Caterina, additional, Catalano, Giovanni, additional, Mastrosimini, Maria Gaia, additional, Becker, Jan , additional, Ernst, Angela, additional, Rizzo, Paola Chiara, additional, Caldonazzi, Nicolo, additional, Vasuri, Francesco, additional, Malvi, Deborah, additional, Fanelli, Giuseppe Nicolo, additional, Naccarato, Giuseppe, additional, Ghimenton, Claudio, additional, L'Imperio, Vincenzo, additional, Mescoli, Claudia, additional, Eccher, Albino, additional, Furian, Lucrezia, additional, and Pagni, Fabio, additional

Published
2023
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8. Digital pathology world tour

Author

Rizzo, Paola Chiara, primary, Caputo, Alessandro, additional, Maddalena, Eddy, additional, Caldonazzi, Nicolò, additional, Girolami, Ilaria, additional, Dei Tos, Angelo Paolo, additional, Scarpa, Aldo, additional, Sbaraglia, Marta, additional, Brunelli, Matteo, additional, Gobbo, Stefano, additional, Marletta, Stefano, additional, Pantanowitz, Liron, additional, Della Mea, Vincenzo, additional, and Eccher, Albino, additional

Published
2023
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10. Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology

Author

Antonini, Pietro, primary, Santonicco, Nicola, additional, Pantanowitz, Liron, additional, Girolami, Ilaria, additional, Rizzo, Paola Chiara, additional, Brunelli, Matteo, additional, Bellevicine, Claudio, additional, Vigliar, Elena, additional, Negri, Giovanni, additional, Troncone, Giancarlo, additional, Fadda, Guido, additional, Parwani, Anil, additional, Marletta, Stefano, additional, and Eccher, Albino, additional

Published
2022
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13. Technical and Diagnostic Issues in Whole Slide Imaging Published Validation Studies

Author

Rizzo, Paola Chiara, primary, Girolami, Ilaria, additional, Marletta, Stefano, additional, Pantanowitz, Liron, additional, Antonini, Pietro, additional, Brunelli, Matteo, additional, Santonicco, Nicola, additional, Vacca, Paola, additional, Tumino, Nicola, additional, Moretta, Lorenzo, additional, Parwani, Anil, additional, Satturwar, Swati, additional, Eccher, Albino, additional, and Munari, Enrico, additional

Published
2022
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14. The Immunohistochemical Loss of H3K27me3 in Intracranial Meningiomas Predicts Shorter Progression-Free Survival after Stereotactic Radiosurgery

Author

Ammendola, Serena, primary, Rizzo, Paola Chiara, additional, Longhi, Michele, additional, Zivelonghi, Emanuele, additional, Pedron, Serena, additional, Pinna, Giampietro, additional, Sala, Francesco, additional, Nicolato, Antonio, additional, Scarpa, Aldo, additional, and Barresi, Valeria, additional

Published
2022
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16. Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology.

Author

Antonini, Pietro, Santonicco, Nicola, Pantanowitz, Liron, Girolami, Ilaria, Rizzo, Paola Chiara, Brunelli, Matteo, Bellevicine, Claudio, Vigliar, Elena, Negri, Giovanni, Troncone, Giancarlo, Fadda, Guido, Parwani, Anil, Marletta, Stefano, and Eccher, Albino

Subjects
CYTODIAGNOSIS, PATHOLOGISTS, DIAGNOSTIC imaging, CELLULAR pathology, PATHOLOGY
Abstract

Whole slide imaging (WSI) allows pathologists to view virtual versions of slides on computer monitors. With increasing adoption of digital pathology, laboratories have begun to validate their WSI systems for diagnostic purposes according to reference guidelines. Among these the College of American Pathologists (CAP) guideline includes three strong recommendations (SRs) and nine good practice statements (GPSs). To date, the application of WSI to cytopathology has been beyond the scope of the CAP guideline due to limited evidence. Herein we systematically reviewed the published literature on WSI validation studies in cytology. A systematic search was carried out in PubMed‐MEDLINE and Embase databases up to November 2021 to identify all publications regarding validation of WSI in cytology. Each article was reviewed to determine if SRs and/or GPSs recommended by the CAP guideline were adequately satisfied. Of 3963 retrieved articles, 25 were included. Only 4/25 studies (16%) satisfied all three SRs, with only one publication (1/25, 4%) fulfilling all three SRs and nine GPSs. Lack of a suitable validation dataset was the main missing SR (16/25, 64%) and less than a third of the studies reported intra‐observer variability data (7/25, 28%). Whilst the CAP guideline for WSI validation in clinical practice helped the widespread adoption of digital pathology, more evidence is required to routinely employ WSI for diagnostic purposes in cytopathology practice. More dedicated validation studies satisfying all SRs and/or GPSs recommended by the CAP are needed to help expedite the use of WSI for primary diagnosis in cytopathology. [ABSTRACT FROM AUTHOR]

Published
2023
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