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13. Barrett’s epithelium after antireflux surgery

Author

Zaninotto, Giovanni, Cassaro, Mauro, Pennelli, Gianmaria, Battaglia, Giorgio, Farinati, Fabio, Ceolin, Martina, Costantini, Mario, Ruol, Alberto, Guirroli, Emanuela, Rizzetto, Christian, Portale, Giuseppe, Ancona, Ermanno, and Rugge, Massimo

Published
2005
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20. CDX2 hox gene product in a rat model of esophageal cancer

Author

Rizzetto Christian, Polimeno Lorenzo, Castoro Carlo, Dazzo Emanuela, Mescoli Claudia, Fassan Matteo, Segat Daniela, Dall'Olmo Luigi, Ingravallo Giuseppe, Baroni Maurizio, Zaninotto Giovanni, Ancona Ermanno, and Rugge Massimo

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Barrett's mucosa is the precursor of esophageal adenocarcinoma. The molecular mechanisms behind Barrett's carcinogenesis are largely unknown. Experimental models of longstanding esophageal reflux of duodenal-gastric contents may provide important information on the biological sequence of the Barrett's oncogenesis. Methods The expression of CDX2 hox-gene product was assessed in a rat model of Barrett's carcinogenesis. Seventy-four rats underwent esophago-jejunostomy with gastric preservation. Excluding perisurgical deaths, the animals were sacrificed at various times after the surgical treatment (Group A: 30 weeks). Results No Cdx2 expression was detected in either squamous epithelia of the proximal esophagus or squamous cell carcinomas. De novo Cdx2 expression was consistently documented in the proliferative zone of the squamous epithelium close to reflux ulcers (Group A: 68%; Group B: 64%; Group C: 80%), multilayered epithelium and intestinal metaplasia (Group A: 9%; Group B: 41%; Group C: 60%), and esophageal adenocarcinomas (Group B: 36%; Group C: 35%). A trend for increasing overall Cdx2 expression was documented during the course of the experiment (p = 0.001). Conclusion De novo expression of Cdx2 is an early event in the spectrum of the lesions induced by experimental gastro-esophageal reflux and should be considered as a key step in the morphogenesis of esophageal adenocarcinoma.

Published
2009
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27. Interval Between Neoadjuvant Chemoradiotherapy and Surgery for Squamous Cell Carcinoma of the Thoracic Esophagus

Author

Ruol, Alberto, primary, Rizzetto, Christian, additional, Castoro, Carlo, additional, Cagol, Matteo, additional, Alfieri, Rita, additional, Zanchettin, Gianpietro, additional, Cavallin, Francesco, additional, Michieletto, Silvia, additional, Da Dalt, Gianfranco, additional, Sileni, Vanna Chiarion, additional, Corti, Luigi, additional, Mantoan, Silvia, additional, Zaninotto, Giovanni, additional, and Ancona, Ermanno, additional

Published
2010
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28. 187 MicroRNA Expression Profiling of Human Barrett's Carcinogenesis

Author

Fassan, Matteo, primary, Volinia, Stefano, additional, Palatini, Jeff, additional, Pizzi, Marco, additional, Baffa, Raffaele, additional, Clemente, Roberto, additional, Rizzetto, Christian, additional, Croce, Carlo M., additional, Zaninotto, Giovanni, additional, Ancona, Ermanno, additional, and Rugge, Massimo, additional

Published
2010
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29. T1912 Association Between Ccttt Pentanucleotide Repeat in the Inducible Nitric Oxide Synthase Promoter Polymorphism and Achalasia

Author

Sarnelli, Giovanni, primary, Grosso, Michela, additional, Cirillo, Carla, additional, Palumbo, Ilaria, additional, Rizzetto, Christian, additional, Zaninotto, Giovanni, additional, Latiano, Anna, additional, Annese, Vito, additional, Savarese, Maria Flavia, additional, Petruzzelli, Raffaella, additional, Izzo, Paola, additional, Sepulveres, Rosanna, additional, D'Agostino, Elio, additional, and Cuomo, Rosario, additional

Published
2010
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30. 288 The Preoperative Manometric Pattern Predicts the Outcome of Surgical Treatment for Esophageal Achalasia

Author

Salvador, Renato, primary, Costantini, Mario, additional, Zaninotto, Giovanni, additional, Morbin, Tiziana, additional, Rizzetto, Christian, additional, Zanatta, Lisa, additional, Ceolin, Martina, additional, Finotti, Elena, additional, Guirroli, Emanuela, additional, Nicoletti, Loredana, additional, Cavallin, Francesco, additional, Da Dalt, Gianfranco, additional, and Ancona, Ermanno, additional

Published
2010
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32. CDX2 hox gene product in a rat model of esophageal cancer

Author

Ingravallo, Giuseppe, primary, Dall'Olmo, Luigi, additional, Segat, Daniela, additional, Fassan, Matteo, additional, Mescoli, Claudia, additional, Dazzo, Emanuela, additional, Castoro, Carlo, additional, Polimeno, Lorenzo, additional, Rizzetto, Christian, additional, Baroni, Maurizio David, additional, Zaninotto, Giovanni, additional, Ancona, Ermanno, additional, and Rugge, Massimo, additional

Published
2009
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36. Four Hundred Laparoscopic Myotomies for Esophageal Achalasia

Author

Zaninotto, Giovanni, primary, Costantini, Mario, additional, Rizzetto, Christian, additional, Zanatta, Lisa, additional, Guirroli, Emanuela, additional, Portale, Giuseppe, additional, Nicoletti, Loredana, additional, Cavallin, Francesco, additional, Battaglia, Giorgio, additional, Ruol, Alberto, additional, and Ancona, Ermanno, additional

Published
2008
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37. 340 Zenker's Diverticula: Is a Tailored Approach Feasible?

Author

Rizzetto, Christian, primary, Costantini, Mario, additional, Bottin, Raffaele, additional, Finotti, Elena, additional, Zanatta, Lisa, additional, Ceolin, Martina, additional, Nicoletti, Loredana, additional, Zaninotto, Giovanni, additional, and Ancona, Ermanno, additional

Published
2008
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39. W1895 Esophageal Achalasia and Risk of Cancer: A Retrospective Cohort Study in Italy

Author

Costantini, Mario, primary, Finotti, Elena, additional, Rizzetto, Christian, additional, Zambon, Paola, additional, Guzzinati, Stefano, additional, Zanatta, Lisa, additional, Ceolin, Martina, additional, Guirroli, Emanuela, additional, Nicoletti, Loredana, additional, Zaninotto, Giovanni, additional, Peracchia, Alberto, additional, and Ancona, Ermanno, additional

Published
2008
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40. Vagal-Sparing Esophagectomy

Author

Peyre, Christian G., primary, DeMeester, Steven R., additional, Rizzetto, Christian, additional, Bansal, Neeraj, additional, Tang, Andrew L., additional, Ayazi, Shahin, additional, Leers, Jessica M., additional, Lipham, John C., additional, Hagen, Jeffrey A., additional, and DeMeester, Tom R., additional

Published
2007
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44. Programmed cell death 4 protein in esophageal cancer.

Author

Fassan M, Cagol M, Pennelli G, Rizzetto C, Giacomelli L, Battaglia G, Zaninotto G, Ancona E, Ruol A, and Rugge M

Subjects
Adenocarcinoma diagnosis, Adenocarcinoma genetics, Adenocarcinoma pathology, Adult, Aged, Aged, 80 and over, Apoptosis Regulatory Proteins genetics, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell pathology, Esophageal Neoplasms diagnosis, Esophageal Neoplasms genetics, Esophageal Neoplasms pathology, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Proteins genetics, Neoplasm Proteins metabolism, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Precancerous Conditions diagnosis, Precancerous Conditions metabolism, Prognosis, RNA-Binding Proteins genetics, Adenocarcinoma metabolism, Apoptosis Regulatory Proteins metabolism, Carcinoma, Squamous Cell metabolism, Esophageal Neoplasms metabolism, RNA-Binding Proteins metabolism
Abstract

Screening for genes down-regulated in esophageal cancers (Oncomine database) pinpointed programmed cell death 4 (PDCD4) as one of the most consistently involved. PDCD4 is a new putative tumor suppressor gene implicated in cell transformation, tumorigenesis, and invasiveness. Based on such a biological rationale, the aim of the present study was to evaluate the prognostic value of PDCD4 in esophageal cancers. The immunohistochemical expression of PDCD4 protein was assessed in 111 consecutive esophageal cancers (63 adenocarcinomas and 48 squamous cell carcinomas) and paired non-cancerous samples. PDCD4 immunostaining was significantly lower in cancer samples than in non-cancerous mucosa (p<0.001). In all cases, the native esophageal epithelium consistently expressed nuclear PDCD4, which was significantly less expressed (37/111 cases) or completely lacking (31/111 cases) in the cancer samples. A significant inverse correlation emerged between nuclear PDCD4 expression and tumor stage (p=0.002), pT (p<0.001), nodal metastasis (p=0.038), and with both vascular (p=0.005) and perineural invasion (p=0.004). Nuclear PDCD4 expression was associated with a longer disease-free (p=0.011) and overall (p=0.021) survival. PDCD4 expression predicts the patient outcome in esophageal cancers. Additional functional studies should look into the role of PDCD4 in the multistep process of esophageal oncogenesis also inquiring on the clinical usefulness of the protein expression as prognostic marker in esophageal precancerous lesions.

Published
2010
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45. Vagal-sparing esophagectomy: the ideal operation for intramucosal adenocarcinoma and barrett with high-grade dysplasia.

Author

Peyre CG, DeMeester SR, Rizzetto C, Bansal N, Tang AL, Ayazi S, Leers JM, Lipham JC, Hagen JA, and DeMeester TR

Subjects
Adenocarcinoma surgery, Aged, Barrett Esophagus surgery, Body Weight physiology, Diarrhea prevention & control, Dumping Syndrome prevention & control, Esophageal Neoplasms surgery, Esophagus physiopathology, Female, Follow-Up Studies, Hospitalization, Humans, Length of Stay, Male, Middle Aged, Neoplasm Recurrence, Local pathology, Postoperative Complications prevention & control, Retrospective Studies, Survival Rate, Treatment Outcome, Esophagectomy methods, Vagus Nerve physiology
Abstract

Objective: Our aim was to compare outcome of vagal-sparing esophagectomy with transhiatal and en bloc esophagectomy in patients with intramucosal adenocarcinoma or high-grade dysplasia., Summary Background Data: Intramucosal adenocarcinoma and high grade dysplasia have a low likelihood of lymphatic or systemic metastases and esophagectomy is curative in most patients. However, traditional esophagectomy is associated with significant morbidity and altered gastrointestinal function. A vagal-sparing esophagectomy offers the advantages of complete disease removal with the potential for reduced morbidity and a better functional outcome., Method: Retrospective review of outcome in patients with intramucosal adenocarcinoma or high grade dysplasia that had a vagal-sparing (n=49), transhiatal (n=39) or en bloc (n=21) esophagectomy., Results: The length of hospital stay and the incidence of major complications was significantly reduced with a vagal-sparing esophagectomy compared with a transhiatal or en bloc resection. Further, postvagotomy dumping and diarrhea symptoms were significantly less common, and weight was better maintained postoperatively with a vagal-sparing esophagectomy. Recurrent cancer has developed in only 1 patient., Conclusion: Survival with intramucosal adenocarcinoma or Barrett's with high-grade dysplasia is independent of the type of resection. A vagal-sparing esophagectomy is associated with significantly less perioperative morbidity and a shorter hospital stay than a transhiatal or en bloc esophagectomy. Further, late morbidity including weight loss, dumping, and diarrhea are significantly less likely after a vagal-sparing approach. Consequently a vagal-sparing esophagectomy is the preferred procedure for patients with intramucosal adenocarcinoma or high grade dysplasia.

Published
2007
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