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721 results on '"Rizzari, Carmelo"'

1. Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059

Author

Wu, Jen-Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C. J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Starý, Jan, Díaz-de-Heredia, Cristina, Rives, Susana, O’Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoît, Rialland, Fanny, Plat, Geneviève, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, and Huitema, Alwin D. R.

Published
2024
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4. Retrospective comparative analysis of two medical evacuation systems for Ukrainian patients affected by war

Author

Adyrov, Mykhaylo V, Alanbousi, Inna, Alexander, Sarah Weeks, Apel, Anna, Avula, Meghana, Bal, Wioletta Anna, Balwierz, Walentyna Aniela, Basset-Salom, Luisa, Bastardo Blanco, Daniel, Bauer, Karolina Jadwiga, Bayazitov, Ildar T, Berlanga, Pablo, Bhakta, Nickhill Hitesh, Bieniek, Katarzyna Anna, Bien, Ewa Iwona, Blackwood, Christopher Andrew, Blair, Sally Jane, Bodak, Khrystyna Ihorivna, Bordeianu, Irina, Bouffet, Eric Eric, Braganca, Joao Maria, Bucurenci, Mihaela Silvia, Budny, Elżbieta Beata, Budzyn, Andrii, Bumgardner, Christopher Carl, Burditt, Raina Nichole, Burnside Clapp, Victoria, Bykov, Viacheslav Valeriyovych, Cañete, Adela, Carnelli, Monica, Cela, Elena, Cepowska, Zuzanna, Chaber, Radoslaw, Cherner-Drieux, Anna, Chubata, Mariya, Clough, Heidi M, Czauderna, Piotr Stefan, Czernicka - Siwecka, Jolanta, Czyzewski, Krzysztof, Dalle, Jean-Hugues, Dashchakovska, Olha, de Koning, Linda A, Dembowska-Baginska, Bozenna Malgorzata, Derwich, Katarzyna, Dirksen, Uta, Dommett, Rachel, Dorosh, Olha Ihorivna, dos Reis Farinha, Nuno Jorge, Drabko, Katarzyna Anna, Dragomir, Monica Desiree, Dutkiewicz, Malgorzata, Dworzak, Michael, Dyma, Sergii Vitaliiovych, Earl, Julian, Eggert, Angelika, English, Martin William, Farren, Becky S, Fedyk, Nataliia Yuriina, Fernández-Teijeiro, Ana, Ferneza, Severyn Romanovych, Foster, Whitney Baer, Fox Irwin, Leeanna Elizabeth, Gałązkowski, Robert Maciej, Ganieva, Galyna, Garanzha, Vasylyna Andriivna, Gelman, Marina S, Godzinski, Jan Krzysztof, Goeres, Anne Françoise, Golban, Rodica, Graetz, Dylan Elizabeth, Greiner, Jeanette, Griksaitis, Michael J, Gupta, Sumit, Hampel, Michal Andrzej, Hastings, Sara Grace, Heenen, Delphine Liliane, Hill, Marcela C, Holiuk, Ihor, Holter, Wolfgang, Hough, Rachael Emma, Hutnik, Lukasz Marek, Irga-Jaworska, Ninela, Istomin, Oleksandr Andriyovych, Ignatova, Anna, Janczar, Szymon Lech, Kacharian, Arman, Kalwak, Krzysztof, Karolczyk, Grażyna Małgorzata, Karpenko, Nataliia Mikolaivna, Katsubo, Halyna Oleksandrivna, Kattamis, Antonis, Kazanowska, Bernarda Jadwiga, Kentsis, Alex, Ketteler, Petra, Kienesberger, Anita, Kiselev, Roman, Kizyma, Zoryana Petrivna, Kliuchkivska, Khrystyna, Klymniuk, Hryhorii Ivanovych, Kolenova, Alexandra, Kolodrubiec, Julia, Kostiuk, Yuliia, Kowalik, Tomasz, Kozlova, Olena Igorivna, Kozubenko, Vladyslav, Kraal, Kathelijne, Kramar, Tetyana Oleksandrivna, Krawczuk-Rybak, Maryna Maryna, Kulemzina, Irina, Kurkowska, Paulina, Kuzyk, Andriy S., Ladenstein, Ruth Lydia, Laguna, Pawel Jozef, Lassaletta, Alvaro, Lehmberg, Kai, Leontieva, Oksana, Liashenko, Serhii, Loizou, Loizos G., Lucchetta, Sonia Anna, Lupo, Matthew William, Lysytsia, Lesya, Lysytsia, Oleksandr, Machnik, Katarzyna Anna, Massimino, Maura, Mainland, Jeff A, Matczak, Katarzyna, Matysiak, Michal Jacek, Mayeur, Pierre, Miller, Beth Anne, Minervina, Anastasia A, Mishkova, Volha, Mizia-Malarz, Agnieszka Joanna, Morales La Madrid, Andres, Moreira, Daniel C, Moreno, Lucas, Moskvin, Vadim P, Mukkada, Sheena Teresa, Muszyńska-Rosłan, Katarzyna Maria, Mykychak, Iryna Volodymyrivna, Niemeyer, Charlotte, Nelson, Akoya Janae', Nogovitsyna, Yuliya, Ociepa, Tomasz, Oltolini, Stefano, Onipko, Nataliia, Pappas, Andrew, Patel, Amit B, Patrahau, Alina Alina, Pauley, Jennifer L., Pavlenko, Yehor Mikhailovich, Pavlovych, Andrij Oleksandrovych, Peregud-Pogorzelski, Jarosław Władyslaw, Perek-Polnik, Marta, Pérez, Vanesa, Pérez-Martínez, Antonio, Pikman, Yana, Pitozzi, Graziano Pitozzi, Portugal, Rui Gentil, Posternak, Victoria Vita, Pleshkan, Viktoriya, Prete, Arcangelo, Pritchard-Jones, Kathy, Raciborska, Anna, Radaelli, Alessandra, Reeves, Tegan Jemma, Reinhardt, Dirk, Reshetnyak, Andrey V, Rider, Andrew Jacob, Rizzari, Carmelo, Rizzi, Damiano Damiano, Rodriguez Hermosillo, Karen Gabriela, Ronenko, Olena Volodymyrivna, Rostkowska, Aneta Olga, Rudko, Liudmyla Yaroslavivna, Sakaan, Firas Mohamed, Sakhar, Nadezhda Aleksandrovna, Salman, Zeena S, Savva, Natallia N., Scaccaglia, Davide, Schaeffer, Elizabeth Hawthorne, Schneider, Carina Ursula, Scobie, Nicole, Semeniuk, Olena Volodymyrivna, Shevchyk, Roksoliana, Shuler, Ana I., Shvets, Stanislav, Sniderman, Liz, Skoczen, Szymon Pawel, Smeal, William John, Sokolowski, Igor, Sonkin, Anna Alexandra, Spolinyak, Andriy, Spota, Andrea, Sramkova, Lucie, Stepanjuk, Alla Ivanivna, Sterba, Jaroslav, Strahm, Brigitte, Styczynski, Jan, Svintsova, Olha, Synyuta, Andriy V, Szczepanski, Tomasz, Szczucinski, Pawel Kukiz, Szmyd, Bartosz Miroslaw, Tasso Cereceda, Maria, Teliuk, Alina, Tomanek, Iwona, Topping, Phoebe, Torrent, Montserrat, Trelińska, Joanna, Troyanovska, Olha Orestivna, Tsurkan, Lyudmila G., Tsymbalyuk-Voloshyn, Iryna, Tyupa, Sergiy Ihorovych, Urasinski, Tomasz Franciszek, Urbanek Dądela, Agnieszka, Vasilieva, Nataliia Jroslavivna, Vasilyeva, Aksana, Verdú-Amorós, Jaime, Vilcu-Bajurean, Natalia, Vinitsky, Leo, Vivtcharenko, Victoria, Vovk, Nelia, Volpe, Giovanni, Vorobel, Oksana Ivanivna, Wachowiak, Jacek Tadeusz, Wasiak, Marcin Slawomir, Wiedower, Lance Allan, Wobst, Natalia, Wuenschel, Lena Isolde, Wysocki, Mariusz Stanislaw, Yurieva, Marina, Zagurska, Anastasiia, Zakharenko, Stanislav S, Zakharenko, Aelita V, Zapotochna, Khrystyna, Zawitkowska, Joanna Emilia, Zecca, Marco, Mueller, Alexandra, Salek, Marta, Oszer, Aleksandra, Evseev, Dmitry, Yakimkova, Taisiya, Wlodarski, Marcin, Vinitsky, Anna, Kizyma, Roman, Pogorelyy, Mikhail, Zuber, Maria, Escalante, Juan, Lipska, Elzbieta, Fendler, Wojciech, Nowicka, Zuzanna, Szyszka, Adam, Rodriguez-Galindo, Carlos, Wise, Paul H., Agulnik, Asya, and Mlynarski, Wojciech

Published
2024
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5. Tackling the implementation gap for the uptake of NGS and advanced molecular diagnostics into healthcare systems

Author

Horgan, Denis, Van den Bulcke, Marc, Malapelle, Umberto, Troncone, Giancarlo, Normanno, Nicola, Capoluongo, Ettore D., Prelaj, Arsela, Rizzari, Carmelo, Trapani, Dario, Singh, Jaya, Kozaric, Marta, Longshore, John, Ottaviano, Manuel, Boccia, Stefania, Pravettoni, Gabriella, Cattaneo, Ivana, Malats, Núria, Buettner, Reinhard, Lekadir, Karim, de Lorenzo, Francesco, Hofman, Paul, and De Maria, Ruggero

Published
2024
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6. The long-term efficacy and safety of nilotinib in pediatric patients with CML: a 5-year update of the DIALOG study

Author

Hijiya, Nobuko, Maschan, Alexey, Rizzari, Carmelo, Shimada, Hiroyuki, Dufour, Carlo, Goto, Hiroaki, Kang, Hyoung Jin, Guinipero, Terri, Karakas, Zeynep, Bautista, Francisco, Ducassou, Stéphane, Yoo, Keon Hee, Zwaan, Christian Michel, Millot, Frédéric, Patterson, Briana C., Samis, Jill, Izquierdo, Miguel, Titorenko, Ksenia, Li, Sai, and Sosothikul, Darintr

Published
2023
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7. Improved survival and MRD remission with blinatumomab vs. chemotherapy in children with first high-risk relapse B-ALL

Author

Locatelli, Franco, Zugmaier, Gerhard, Rizzari, Carmelo, Morris, Joan D., Gruhn, Bernd, Klingebiel, Thomas, Parasole, Rosanna, Linderkamp, Christin, Flotho, Christian, Petit, Arnaud, Micalizzi, Concetta, Zeng, Yi, Desai, Rajendra, Kormany, William N., Eckert, Cornelia, Möricke, Anja, Sartor, Mary, Hrusak, Ondrej, Peters, Christina, Saha, Vaskar, Vinti, Luciana, and von Stackelberg, Arend

Published
2023
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8. Inotuzumab ozogamicin as single agent in pediatric patients with relapsed and refractory acute lymphoblastic leukemia: results from a phase II trial

Author

Pennesi, Edoardo, Michels, Naomi, Brivio, Erica, van der Velden, Vincent H. J., Jiang, Yilin, Thano, Adriana, Ammerlaan, Anneke J. C., Boer, Judith M., Beverloo, H. Berna, Sleight, Barbara, Chen, Ying, Vormoor-Bürger, Britta, Rives, Susana, Bielorai, Bella, Rössig, Claudia, Petit, Arnaud, Rizzari, Carmelo, Engstler, Gernot, Starý, Jan, Bautista Sirvent, Francisco J., Chen-Santel, Christiane, Bruno, Benedicte, Bertrand, Yves, Rialland, Fanny, Plat, Geneviève, Reinhardt, Dirk, Vinti, Luciana, Von Stackelberg, Arend, Locatelli, Franco, and Zwaan, Christian M.

Published
2022
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9. PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120

Author

Fazio, Grazia, Bresolin, Silvia, Silvestri, Daniela, Quadri, Manuel, Saitta, Claudia, Vendramini, Elena, Buldini, Barbara, Palmi, Chiara, Bardini, Michela, Grioni, Andrea, Rigamonti, Silvia, Galbiati, Marta, Mecca, Stefano, Savino, Angela Maria, Peloso, Alberto, Tu, Jia-Wey, Bhatia, Sanil, Borkhardt, Arndt, Micalizzi, Concetta, Lo Nigro, Luca, Locatelli, Franco, Conter, Valentino, Rizzari, Carmelo, Valsecchi, Maria Grazia, te Kronnie, Geertruij, Biondi, Andrea, and Cazzaniga, Giovanni

Published
2022
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11. Prenatal origin of NUTM1 gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia.

Author

Bardini, Michela, Fazio, Grazia, Abascal, Lilia Corral, Meyer, Claus, Maglia, Oscar, Sala, Simona, Palamini, Sonia, Rebellato, Stefano, Marschalek, Rolf, Rizzari, Carmelo, Biondi, Andrea, and Cazzaniga, Giovanni

Abstract

Summary: Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B‐cell precursor Acute Lymphoblastic Leukaemia (BCP‐ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP‐ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient‐specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP‐ALL. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study.

Author

Tentoni, Nicolás, Hwang, Miriam, Villanueva, Gabriela, Combs, Ryan, Lowe, Jennifer, Ramsey, Laura B., Taylor, Zachary L., Carrillo, Thais Murciano, Aumente, María Dolores, López‐Viñau López, Teresa, Rizzari, Carmelo, and Howard, Scott C.

Subjects
ACUTE kidney failure, DRUG monitoring, RECEIVER operating characteristic curves, GLOMERULAR filtration rate, METHOTREXATE
Abstract

Introduction: High‐dose methotrexate (HDMTX) use can be limited by the development of acute kidney injury (AKI). Early AKI detection is paramount to prevent further renal injury and irreversible toxicities. This study sought to determine whether early elimination patterns of MTX would be useful as a biomarker of AKI in HDMTX treatment. Methods: This retrospective cohort study included two sites that collected ≥2 MTX levels within 16 h from completion of MTX infusion. Early levels were tagged and MTX elimination half‐life (t½) were calculated from combinations of two of three different early time periods. Receiver operating characteristic (ROC) curves were synthesized for each elimination t½ (biomarker) with respect to AKI and delayed methotrexate elimination (DME); the biomarker with the highest area under the ROC curve (AUC) was tested in a multiple variable logistic regression model. Results: Data from 169 patients who received a total of 556 courses of HDMTX were analyzed. ROC analysis revealed MTX elimination t½ calculated from the second and third time periods had the highest AUC for AKI at 0.62 (interquartile range [IQR] 0.56–0.69) and DME at 0.86 (IQR 0.73–1.00). After adjusting for age, sex, dose (mg/m2), infusion duration, HDMTX course, and baseline estimated glomerular filtration rate, it remained significant for AKI with an OR of 1.29 and 95% confidence interval of 1.03–1.65. Conclusion: Early MTX elimination t½ measured within 16 h of infusion completion was significantly associated with the development of AKI and serves as an early clearance biomarker that may identify patients who benefit from increased hydration, augmented leucovorin rescue, and glucarpidase administration. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Asparagine transport through SLC1A5/ASCT2 and SLC38A5/SNAT5 is essential for BCP‐ALL cell survival and a potential therapeutic target

Author

Taurino, Giuseppe, primary, Dander, Erica, additional, Chiu, Martina, additional, Pozzi, Giulia, additional, Maccari, Chiara, additional, Starace, Rita, additional, Silvestri, Daniela, additional, Griffini, Erika, additional, Bianchi, Massimiliano G., additional, Carubbi, Cecilia, additional, Andreoli, Roberta, additional, Mirandola, Prisco, additional, Valsecchi, Maria Grazia, additional, Rizzari, Carmelo, additional, D'Amico, Giovanna, additional, and Bussolati, Ovidio, additional

Published
2024
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15. Demographic Analysis of Cancer Research Priorities and Treatment Correlations

Author

Horgan, Denis, primary, Bulcke, Marc Van den, additional, Malapelle, Umberto, additional, Normanno, Nicola, additional, Capoluongo, Ettore D., additional, Prelaj, Arsela, additional, Rizzari, Carmelo, additional, Stathopoulou, Aliki, additional, Singh, Jaya, additional, Kozaric, Marta, additional, Dube, France, additional, Ottaviano, Manuel, additional, Boccia, Stefania, additional, Pravettoni, Gabriella, additional, Cattaneo, Ivana, additional, Malats, Núria, additional, Buettner, Reinhard, additional, Lekadir, Karim, additional, de Lorenzo, Francesco, additional, Alix-Panabieres, Catherine, additional, Badreh, Sara, additional, Solary, Eric, additional, De Maria, Ruggero, additional, and Hofman, Paul, additional

Published
2024
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16. A phase 2 study of nilotinib in pediatric patients with CML: long-term update on growth retardation and safety

Author

Hijiya, Nobuko, Maschan, Alexey, Rizzari, Carmelo, Shimada, Hiroyuki, Dufour, Carlo, Goto, Hiroaki, Kang, Hyoung Jin, Guinipero, Terri, Karakas, Zeynep, Bautista, Francisco, Ducassou, Stéphane, Yoo, Keon Hee, Zwaan, Christian Michel, Millot, Frédéric, Patterson, Briana, Samis, Jill, Aimone, Paola, Allepuz, Alex, Titorenko, Ksenia, and Sosothikul, Darintr

Published
2021
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17. Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia

Author

Apotheek O&O&O, Cancer, Brigitha, Leiah J., Mondelaers, Veerle, Liu, Yiwei, Albertsen, Birgitte K., Zalewska-Szewczyk, Beata, Rizzari, Carmelo, Kotecha, Rishi S., Pieters, Rob, Huitema, Alwin D.R., van der Sluis, Inge M., Apotheek O&O&O, Cancer, Brigitha, Leiah J., Mondelaers, Veerle, Liu, Yiwei, Albertsen, Birgitte K., Zalewska-Szewczyk, Beata, Rizzari, Carmelo, Kotecha, Rishi S., Pieters, Rob, Huitema, Alwin D.R., and van der Sluis, Inge M.

Published
2024

18. Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059

Author

Apotheek O&O&O, Cancer, Wu, Jen Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C.J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Starý, Jan, Díaz-de-Heredia, Cristina, Rives, Susana, O’Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoît, Rialland, Fanny, Plat, Geneviève, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, Huitema, Alwin D.R., Apotheek O&O&O, Cancer, Wu, Jen Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C.J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Starý, Jan, Díaz-de-Heredia, Cristina, Rives, Susana, O’Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simón, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoît, Rialland, Fanny, Plat, Geneviève, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, and Huitema, Alwin D.R.

Published
2024

19. Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia:Results of Study ITCC-059

Author

Wu, Jen-Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C. J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Stary, Jan, Diaz-de-Heredia, Cristina, Rives, Susana, O'Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simon, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoit, Rialland, Fanny, Plat, Genevieve, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, Huitema, Alwin D. R., Wu, Jen-Hao, Pennesi, Edoardo, Bautista, Francisco, Garrett, May, Fukuhara, Kei, Brivio, Erica, Ammerlaan, Anneke C. J., Locatelli, Franco, van der Sluis, Inge M., Rossig, Claudia, Chen-Santel, Christiane, Bielorai, Bella, Petit, Arnaud, Stary, Jan, Diaz-de-Heredia, Cristina, Rives, Susana, O'Marcaigh, Aengus, Rizzari, Carmelo, Engstler, Gernot, Nysom, Karsten, Rubio-San-Simon, Alba, Bruno, Benedicte, Bertrand, Yves, Brethon, Benoit, Rialland, Fanny, Plat, Genevieve, Dirksen, Uta, Sramkova, Lucie, Zwaan, C. Michel, and Huitema, Alwin D. R.

Abstract

Background and Objective: Inotuzumab ozogamicin is an antibody-drug conjugate approved for treating relapsed/refractory B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in adults. Pediatric pharmacokinetic data of inotuzumab ozogamicin are lacking. This study is the first to examine the population pharmacokinetics of inotuzumab ozogamicin in pediatric patients with relapsed/refractory BCP-ALL. Methods: From 531 adult patients with B-cell non-Hodgkin’s lymphoma, 234 adult patients with BCP-ALL, and 53 pediatric patients with BCP-ALL, 8924 inotuzumab ozogamicin serum concentrations were analyzed using non-linear mixed-effects modeling. A published adult inotuzumab ozogamicin population-pharmacokinetic model, a two-compartment model with linear and time-dependent clearance, was adapted to describe the pediatric data. Results: Modifications in this analysis, compared to the published adult model, included: (i) re-estimating pharmacokinetic parameters and covariate effects; (ii) modifying covariate representation; and (iii) introducing relevant pediatric covariate effects (age on the decay coefficient of time-dependent clearance and ALL effect (disease type and/or different bioanalytical analysis methods) on initial values of time-dependent clearance). For patients with relapsed/refractory BCP-ALL, increasing age was associated with a decreasing decay coefficient of time-dependent clearance, reflecting that the target-mediated drug clearance declines more rapidly in children. In pediatric BCP-ALL, the median [interquartile range] cumulative area under the concentration–time curve was significantly higher among responders (n = 42) versus non-responders (n = 10) at the end of the first cycle (26.1 [18.9–35.0] vs 10.1 [9.19–16.1], × 10 3 ng*h/mL, p < 0.001). From simulations performed at the recommended pediatric phase II dose, inotuzumab ozogamicin exposure reached a similar level as observed in responding pediatric trial participants. Conclusions

Published
2024

20. Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia: Results From the Phase I Part of Study ITCC054/COG AAML1921

Author

Apotheek O&O&O, Cancer, Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E, Huitema, Alwin D R, Jiang, Yilin, van Tinteren, Harm D R, van der Velden, Vincent H J, Beverloo, Berna H, den Boer, Monique L, Rammeloo, Lukas A J, Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J, Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean-Pierre, Motwani, Jayashree, van der Sluis, Inge M, Locatelli, Franco, Roth, Michael E, Hijiya, Nobuko, Zwaan, Christian M, Apotheek O&O&O, Cancer, Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E, Huitema, Alwin D R, Jiang, Yilin, van Tinteren, Harm D R, van der Velden, Vincent H J, Beverloo, Berna H, den Boer, Monique L, Rammeloo, Lukas A J, Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J, Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean-Pierre, Motwani, Jayashree, van der Sluis, Inge M, Locatelli, Franco, Roth, Michael E, Hijiya, Nobuko, and Zwaan, Christian M

Published
2024

21. Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia:Results From the Phase I Part of Study ITCC054/COG AAML1921

Author

Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E., Huitema, Alwin D.R., Jiang, Yilin, Van Tinteren, Harm D.R., Van Der Velden, Vincent H.J., Beverloo, Berna H., Den Boer, Monique L., Rammeloo, Lukas A.J., Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J., Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean Pierre, Motwani, Jayashree, Van Der Sluis, Inge M., Locatelli, Franco, Roth, Michael E., Hijiya, Nobuko, Zwaan, Christian M., Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E., Huitema, Alwin D.R., Jiang, Yilin, Van Tinteren, Harm D.R., Van Der Velden, Vincent H.J., Beverloo, Berna H., Den Boer, Monique L., Rammeloo, Lukas A.J., Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J., Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, Murillo-Sanjuán, Laura, Kutny, Matthew, Zarnegar-Lumley, Sara, Redell, Michele, Cooper, Stacy, Bertrand, Yves, Petit, Arnaud, Krystal, Julie, Metzler, Markus, Lancaster, Donna, Bourquin, Jean Pierre, Motwani, Jayashree, Van Der Sluis, Inge M., Locatelli, Franco, Roth, Michael E., Hijiya, Nobuko, and Zwaan, Christian M.

Abstract

PURPOSE Bosutinib is approved for adults with chronic myeloid leukemia (CML): 400 mg once daily in newly diagnosed (ND); 500 mg once daily in resistant/intolerant (R/I) patients. Bosutinib has a different tolerability profile than other tyrosine kinase inhibitors (TKIs) and potentially less impact on growth (preclinical data). The primary objective of this first-in-child trial was to determine the recommended phase II dose (RP2D) for pediatric R/I and ND patients. PATIENTS AND METHODS In the phase I part of this international, open-label trial (ClinicalTrials.gov identifier: NCT04258943), children age 1-18 years with R/I (per European LeukemiaNet 2013) Ph+ CML were enrolled using a 6 + 4 design, testing 300, 350, and 400 mg/m2 once daily with food. The RP2D was the dose resulting in 0/6 or 1/10 dose-limiting toxicities (DLTs) during the first cycle and achieving adult target AUC levels for the respective indication. As ND participants were only enrolled in phase II, the ND RP2D was selected based on data from R/I patients. Results Thirty patients were enrolled; 27 were evaluable for DLT: six at 300 mg/m2, 11 at 350 mg/m2 (one DLT), and 10 at 400 mg/m2 (one DLT). The mean AUCs at 300 mg/m2, 350 mg/m2, and 400 mg/m2 were 2.20 g h/mL, 2.52 g h/mL, and 2.66 g h/mL, respectively. The most common adverse event was diarrhea (93%; ≥grade 3: 11%). Seven patients stopped because of intolerance and eight because of insufficient response. Complete cytogenetic and major molecular response to bosutinib appeared comparable with other published phase I/II trials with second-generation TKIs in children. CONCLUSION Bosutinib was safe and effective. The pediatric RP2D was 400 mg/m2 once daily (max 600 mg/d) with food in R/I patients and 300 mg/m2 once daily (max 500 mg/d) with food in ND patients, which achieved targeted exposures as per adult experience.

Published
2024

23. Aligning Cancer Research Priorities in Europe with Recommendations for Conquering Cancer: A Comprehensive Analysis

Author

Horgan, Denis, primary, Bulcke, Marc Van den, additional, Malapelle, Umberto, additional, Normanno, Nicola, additional, Capoluongo, Ettore D., additional, Prelaj, Arsela, additional, Rizzari, Carmelo, additional, Stathopoulou, Aliki, additional, Singh, Jaya, additional, Kozaric, Marta, additional, Dube, France, additional, Ottaviano, Manuel, additional, Boccia, Stefania, additional, Pravettoni, Gabriella, additional, Cattaneo, Ivana, additional, Malats, Núria, additional, Buettner, Reinhard, additional, Lekadir, Karim, additional, de Lorenzo, Francesco, additional, Blanc, Patricia, additional, Alix-Panabieres, Catherine, additional, Badreh, Sara, additional, Hofman, Paul, additional, Solary, Eric, additional, and De Maria, Ruggero, additional

Published
2024
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24. Inotuzumab ozogamicin combined with chemotherapy in pediatric B-cell precursor CD22+ acute lymphoblastic leukemia: results of the phase IB ITCC-059 trial

Author

Pennesi, Edoardo, primary, Brivio, Erica, additional, Ammerlaan, Anneke C. J., additional, Jiang, Yilin, additional, Van der Velden, Vincent H. J., additional, Beverloo, H. Berna, additional, Sleight, Barbara, additional, Locatelli, Franco, additional, Brethon, Benoit, additional, Rossig, Claudia, additional, Engstler, Gernot, additional, Nilsson, Anna, additional, Bruno, Benedicte, additional, Petit, Arnaud, additional, Bielorai, Bella, additional, Rizzari, Carmelo, additional, Rialland, Fanny, additional, Rubio-San-Simón, Alba, additional, Sirvent, Francisco J. Bautista, additional, Diaz-de-Heredia, Cristina, additional, Rives, Susana, additional, and Zwaan, Christian M., additional

Published
2024
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26. Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine

Author

Salek, Marta, primary, Mueller, Alexandra, additional, Alanbousi, Inna, additional, Cepowska, Zuzanna, additional, Dutkiewicz, Malgorzata, additional, Earl, Julian, additional, Evseev, Dmitry, additional, Kizyma, Roman, additional, Kliuchkivska, Khrystyna, additional, Kolodrubiec, Julia, additional, Matczak, Katarzyna, additional, Nogovitsyna, Yuliya, additional, Oszer, Aleksandra, additional, Pogorelyy, Mikhail, additional, Raciborska, Anna, additional, Rasul, Suheir, additional, Sokolowski, Igor, additional, Sopilnyak, Andriy, additional, Vinitsky, Anna, additional, Wlodarski, Marcin W, additional, Wobst, Natalia, additional, Yakimkova, Taisiya, additional, Rodriguez-Galindo, Carlos, additional, Wise, Paul H, additional, Mlynarski, Wojciech, additional, Agulnik, Asya, additional, Alexander, Sarah Weeks, additional, Apel, Anna, additional, Adyrov, Mykhaylo V, additional, Avula, Meghana, additional, Bal, Wioletta Anna, additional, Balwierz, Walentyna Aniela, additional, Basset-Salom, Luisa, additional, Bastardo Blanco, Daniel, additional, Bauer, Karolina Jadwiga, additional, Bayazitov, Ildar T, additional, Berlanga, Pablo, additional, Bhakta, Nickhill Hitesh, additional, Bieniek, Katarzyna Anna, additional, Bien, Ewa Iwona, additional, Blackwood, Christopher Andrew, additional, Blair, Sally Jane, additional, Bodak, Khrystyna Ihorivna, additional, Bordeianu, Irina, additional, Bouffet, Eric, additional, Braganca, Joao Maria, additional, Bucurenci, Mihaela Silvia, additional, Budny, Elżbieta Beata, additional, Budzyn, Andrii, additional, Bumgardner, Christopher Carl, additional, Burditt, Raina Nichole, additional, Burnside Clapp, Victoria, additional, Bykov, Viacheslav Valeriyovych, additional, Cañete, Adela, additional, Carnelli, Monica, additional, Cela, Elena, additional, Chaber, Radoslaw, additional, Cherner-Drieux, Anna, additional, Chubata, Mariya, additional, Clough, Heidi M, additional, Czauderna, Piotr Stefan, additional, Czernicka - Siwecka, Jolanta, additional, Czyzewski, Krzysztof, additional, Dalle, Jean-Hugues, additional, Dashchakovska, Olha, additional, de Koning, Linda A, additional, Dembowska-Baginska, Bozenna Malgorzata, additional, Derwich, Katarzyna, additional, Dirksen, Uta, additional, Dommett, Rachel, additional, Dorosh, Olha Ihorivna, additional, dos Reis Farinha, Nuno Jorge, additional, Drabko, Katarzyna Anna, additional, Dragomir, Monica Desiree, additional, Dworzak, Michael, additional, Dyma, Sergii Vitaliiovych, additional, Eggert, Angelika, additional, English, Martin William, additional, Farren, Becky S, additional, Fedyk, Nataliia Yuriina, additional, Fernández-Teijeiro, Ana, additional, Ferneza, Severyn Romanovych, additional, Foster, Whitney Baer, additional, Fox Irwin, Leeanna Elizabeth, additional, Gałązkowski, Robert Maciej, additional, Ganieva, Galyna, additional, Garanzha, Vasylyna Andriivna, additional, Gelman, Marina S, additional, Godzinski, Jan Krzysztof, additional, Goeres, Anne Françoise, additional, Golban, Rodica, additional, Graetz, Dylan Elizabeth, additional, Greiner, Jeanette, additional, Griksaitis, Michael J, additional, Gupta, Sumit, additional, Hampel, Michal Andrzej, additional, Hastings, Sara Grace, additional, Heenen, Delphine Liliane, additional, Hill, Marcela C, additional, Holiuk, Ihor, additional, Holter, Wolfgang, additional, Hough, Rachael Emma, additional, Hutnik, Lukasz Marek, additional, Irga-Jaworska, Ninela, additional, Istomin, Oleksandr Andriyovych, additional, Ignatova, Anna, additional, Janczar, Szymon Lech, additional, Kacharian, Arman, additional, Kalwak, Krzysztof, additional, Karolczyk, Grażyna Małgorzata, additional, Karpenko, Nataliia Mikolaivna, additional, Katsubo, Halyna Oleksandrivna, additional, Kattamis, Antonis, additional, Kazanowska, Bernarda Jadwiga, additional, Kentsis, Alex, additional, Ketteler, Petra, additional, Kienesberger, Anita, additional, Kiselev, Roman, additional, Kizyma, Zoryana Petrivna, additional, Klymniuk, Hryhorii Ivanovych, additional, Kolenova, Alexandra, additional, Kostiuk, Yuliia, additional, Kowalik, Tomasz, additional, Kozlova, Olena Igorivna, additional, Kozubenko, Vladyslav, additional, Kraal, Kathelijne, additional, Kramar, Tetyana Oleksandrivna, additional, Krawczuk-Rybak, Maryna Maryna, additional, Kulemzina, Irina, additional, Kurkowska, Paulina, additional, Kuzyk, Andriy S., additional, Ladenstein, Ruth Lydia, additional, Laguna, Pawel Jozef, additional, Lassaletta, Alvaro, additional, Lehmberg, Kai, additional, Leontieva, Oksana, additional, Liashenko, Serhii, additional, Loizou, Loizos G., additional, Lucchetta, Sonia Anna, additional, Lupo, Matthew William, additional, Lysytsia, Lesya, additional, Lysytsia, Oleksandr, additional, Machnik, Katarzyna Anna, additional, Massimino, Maura, additional, Mainland, Jeff A, additional, Matysiak, Michal Jacek, additional, Mayeur, Pierre, additional, Miller, Beth Anne, additional, Minervina, Anastasia A, additional, Mishkova, Volha, additional, Mizia-Malarz, Agnieszka Joanna, additional, Morales La Madrid, Andres, additional, Moreira, Daniel C, additional, Moreno, Lucas, additional, Moskvin, Vadim P, additional, Mukkada, Sheena Teresa, additional, Muszyńska-Rosłan, Katarzyna Maria, additional, Mykychak, Iryna Volodymyrivna, additional, Niemeyer, Charlotte, additional, Nelson, Akoya Janae', additional, Ociepa, Tomasz, additional, Oltolini, Stefano, additional, Onipko, Nataliia, additional, Pappas, Andrew, additional, Patel, Amit B, additional, Patrahau, Alina Alina, additional, Pauley, Jennifer L., additional, Pavlenko, Yehor Mikhailovich, additional, Pavlovych, Andrij Oleksandrovych, additional, Peregud-Pogorzelski, Jarosław Władysław, additional, Perek-Polnik, Marta, additional, Pérez, Vanesa, additional, Pérez-Martínez, Antonio, additional, Pikman, Yana, additional, Pitozzi, Graziano Pitozzi, additional, Portugal, Rui Gentil, additional, Posternak, Victoria Vita, additional, Pleshkan, Viktoriya, additional, Prete, Arcangelo, additional, Pritchard-Jones, Kathy, additional, Radaelli, Alessandra, additional, Reeves, Tegan Jemma, additional, Reinhardt, Dirk, additional, Reshetnyak, Andrey V, additional, Rider, Andrew Jacob, additional, Rizzari, Carmelo, additional, Rizzi, Damiano Damiano, additional, Rodriguez Hermosillo, Karen Gabriela, additional, Ronenko, Olena Volodymyrivna, additional, Rostkowska, Aneta Olga, additional, Rudko, Liudmyla Yaroslavivna, additional, Sakaan, Firas Mohamed, additional, Sakhar, Nadezhda Aleksandrovna, additional, Salman, Zeena S, additional, Savva, Natallia N, additional, Scaccaglia, Davide, additional, Schaeffer, Elizabeth Hawthorne, additional, Schneider, Carina Ursula, additional, Scobie, Nicole, additional, Semeniuk, Olena Volodymyrivna, additional, Shevchyk, Roksoliana, additional, Shuler, Ana, additional, Shvets, Stanislav, additional, Sniderman, Liz, additional, Skoczen, Szymon Pawel, additional, Smeal, William John, additional, Sonkin, Anna Alexandra, additional, Spota, Andrea, additional, Sramkova, Lucie, additional, Stepanjuk, Alla Ivanivna, additional, Sterba, Jaroslav, additional, Strahm, Brigitte, additional, Styczynski, Jan, additional, Svintsova, Olha, additional, Synyuta, Andriy V, additional, Szczepanski, Tomasz, additional, Szczucinski, Paweł Kukiz, additional, Szmyd, Bartosz Miroslaw, additional, Tasso Cereceda, Maria, additional, Teliuk, Alina, additional, Tomanek, Iwona, additional, Topping, Phoebe, additional, Torrent, Montserrat, additional, Trelińska, Joanna, additional, Troyanovska, Olha Orestivna, additional, Tsurkan, Lyudmila G., additional, Tsymbalyuk-Voloshyn, Iryna, additional, Tyupa, Sergiy Ihorovych, additional, Urasinski, Tomasz Franciszek, additional, Urbanek Dądela, Agnieszka, additional, Vasilieva, Nataliia Jroslavivna, additional, Vasilyeva, Aksana, additional, Verdú-Amorós, Jaime, additional, Vilcu-Bajurean, Natalia, additional, Vinitsky, Leo, additional, Vivtcharenko, Victoria, additional, Vovk, Nelia, additional, Volpe, Giovanni, additional, Vorobel, Oksana Ivanivna, additional, Wachowiak, Jacek Tadeusz, additional, Wasiak, Marcin Sławomir, additional, Wiedower, Lance Allan, additional, Wuenschel, Lena Isolde, additional, Wysocki, Mariusz Stanislaw, additional, Yurieva, Marina, additional, Zagurska, Anastasiia, additional, Zakharenko, Stanislav S, additional, Zakharenko, Aelita V, additional, Zapotochna, Khrystyna, additional, Zawitkowska, Joanna Emilia, additional, and Zecca, Marco, additional

Published
2023
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27. Phase 2 study of nilotinib in pediatric patients with Philadelphia chromosome–positive chronic myeloid leukemia

Author

Hijiya, Nobuko, Maschan, Alexey, Rizzari, Carmelo, Shimada, Hiroyuki, Dufour, Carlo, Goto, Hiroaki, Kang, Hyoung Jin, Guinipero, Terri, Karakas, Zeynep, Bautista, Francisco, Ducassou, Stéphane, Yoo, Keon Hee, Zwaan, Christian Michel, Millot, Frédéric, Aimone, Paola, Allepuz, Alex, Quenet, Sara, Hourcade-Potelleret, Florence, Hertle, Sabine, and Sosothikul, Darintr

Published
2019
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29. Four Additional Doses of PEG-L-Asparaginase During the Consolidation Phase in the AIEOP-BFM ALL 2009 Protocol Do Not Improve Outcome and Increase Toxicity in High-Risk ALL: Results of a Randomized Study.

Author

Conter, Valentino, Valsecchi, Maria Grazia, Cario, Gunnar, Zimmermann, Martin, Attarbaschi, Andishe, Stary, Jan, Niggli, Felix, Dalla Pozza, Luciano, Elitzur, Sarah, Silvestri, Daniela, Locatelli, Franco, Möricke, Anja, Engstler, Gernot, Smisek, Petr, Bodmer, Nicole, Barbaric, Draga, Izraeli, Shai, Rizzari, Carmelo, Boos, Joachim, and Buldini, Barbara

Published
2024
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30. Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia: Results From the Phase I Part of Study ITCC054/COG AAML1921.

Author

Brivio, Erica, Pennesi, Edoardo, Willemse, Marieke E., Huitema, Alwin D.R., Jiang, Yilin, van Tinteren, Harm D.R., van der Velden, Vincent H.J., Beverloo, Berna H., den Boer, Monique L., Rammeloo, Lukas A.J., Hudson, Chad, Heerema, Nyla, Kowalski, Karey, Zhao, Huadong, Kuttschreuter, Luke, Bautista Sirvent, Francisco J., Bukowinski, Andrew, Rizzari, Carmelo, Pollard, Jessica, and Murillo-Sanjuán, Laura

Published
2024
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31. Mobilising Collaboration among Stakeholders to Optimise the Growing Potential of Data for Tackling Cancer

Author

Horgan, Denis, primary, Van den Bulcke, Marc, additional, Malapelle, Umberto, additional, Normanno, Nicola, additional, Capoluongo, Ettore D., additional, Prelaj, Arsela, additional, Rizzari, Carmelo, additional, Stathopoulou, Aliki, additional, Singh, Jaya, additional, Kozaric, Marta, additional, Dube, France, additional, Ottaviano, Manuel, additional, Boccia, Stefania, additional, Pravettoni, Gabriella, additional, Cattaneo, Ivana, additional, Malats, Núria, additional, Buettner, Reinhard, additional, Lekadir, Karim, additional, de Lorenzo, Francesco, additional, Alix-Panabieres, Catherine, additional, Badreh, Sara, additional, Hofman, Paul, additional, De Maria, Ruggero, additional, and Solary, Eric, additional

Published
2023
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32. Reply to: Comment on: A pooled subgroup analysis of glucarpidase treatment in 86 pediatric, adolescent, and young adult patients receiving high‐dose methotrexate therapy in open‐label trials

Author

Janeway, Katherine A., primary, Gros, Luis, additional, Schwartz, Stefan, additional, Daugherty, Claire, additional, Gallardo, Eva, additional, Hill, Christon, additional, Thomas, Emma, additional, Ward, Suzanne, additional, and Rizzari, Carmelo, additional

Published
2023
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33. Impact of mercaptopurine metabolites on disease outcome in the AIEOP‐BFM 2009 protocol for acute lymphoblastic leukemia

Author

Franca, Raffaella, primary, Stocco, Gabriele, additional, Kiren, Valentina, additional, Tessitore, Antimo, additional, Fagioli, Franca, additional, Quarello, Paola, additional, Bertorello, Nicoletta, additional, Rizzari, Carmelo, additional, Colombini, Antonella, additional, Bettini, Laura Rachele, additional, Locatelli, Franco, additional, Vinti, Luciana, additional, Girardi, Katia, additional, Silvestri, Daniela, additional, Valsecchi, Maria Grazia, additional, Decorti, Giuliana, additional, and Rabusin, Marco, additional

Published
2023
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34. P374: THROMBOTIC EVENTS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA: EXPERIENCE OF ITALIAN AIEOP CENTERS (2009-2017)

Author

Mattera, Raffaele, primary, Caterina Putti, Maria, additional, Biffi, Alessandra, additional, Parasole, Rosanna, additional, Conter, Valentino, additional, Rizzari, Carmelo, additional, Grazia Valsecchi, Maria, additional, Silvestri, Daniela, additional, Biondi, Andrea, additional, Locatelli, Franco, additional, Barisone, Elena, additional, Micalizzi, Concetta, additional, Mina, Tommaso, additional, and Kiren, Valentina, additional

Published
2023
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35. P501: ISATUXIMAB PLUS CHEMOTHERAPY FOR PEDIATRIC RELAPSED/REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA OR ACUTE MYELOID LEUKEMIA (ISAKIDS): INTERIM EFFICACY ANALYSIS

Author

Baruchel, André, primary, Bertrand, Yves, additional, Nysom, Karsten, additional, Jin Kang, Hyoung, additional, Makiya, Monica, additional, Abrahamsson, Jonas, additional, González-Llano, Oscar, additional, Quinones Choque, Willy, additional, Rizzari, Carmelo, additional, Buechner, Jochen, additional, Cesaro, Simone, additional, Duarte, Ximo, additional, Fagioli, Franca, additional, Kattamis, Antonis, additional, Leverger, Guy, additional, Nelken, Brigitte, additional, Wang, Lynn, additional, Mace, Sandrine, additional, Oprea, Corina, additional, Abbadessa, Giovanni, additional, and Zwaan, Michel, additional

Published
2023
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36. P406: INCIDENCE OF COMPLICATIONS OF HIGH-DOSE METHOTREXATE ADMINISTRATION IN ADULTS AND CHILDREN WITH HEMATOLOGIC CANCERS: PRELIMINARY RESULTS FROM A EUROPEAN REGISTRY

Author

Howard, Scott, primary, Combs, Ryan, additional, Lowe, Jennifer, additional, Rizzari, Carmelo, additional, Dolores Aumente, María, additional, Barba Suñol, Pere, additional, Murciano, Thais, additional, Satostegui, Margarita, additional, Sampor, Claudia, additional, and Tentoni, Nicolás, additional

Published
2023
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38. Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction

Author

Möricke, Anja, primary, Rizzari, Carmelo, additional, Alten, Julia, additional, Attarbaschi, Andishe, additional, Beier, Rita, additional, Biondi, Andrea, additional, Burkhardt, Birgit, additional, Bodmer, Nicole, additional, Boos, Joachim, additional, Cario, Gunnar, additional, Conter, Valentino, additional, Flotho, Christian, additional, Kulozik, Andreas, additional, Lanvers-Kaminsky, Claudia, additional, Mann, Georg, additional, Niggli, Felix, additional, Silvestri, Daniela, additional, von Stackelberg, Arend, additional, Stanulla, Martin, additional, Valsecchi, Maria-Grazia, additional, Schrappe, Martin, additional, and Zimmermann, Martin, additional

Published
2023
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40. CD72 is a pan‐tumor antigen associated to pediatric acute leukemia.

Author

Buldini, Barbara, Faggin, Giovanni, Porcù, Elena, Scarparo, Pamela, Polato, Katia, Tregnago, Claudia, Varotto, Elena, Rizzardi, Paolo, Rizzari, Carmelo, Locatelli, Franco, Biffi, Alessandra, and Pigazzi, Martina

Abstract

In the development of novel immunotherapeutic approaches, the step of target identification is a challenging process, because it aims at identifying robust tumor‐associated antigens (TAAs) specific for the pathological population and causing no off‐target effects. Here we propose CD72 as a novel and robust TAA for pediatric acute leukemias. We provided an outline of CD72 expression assessed by flow cytometry on a variety of cancer cell lines and primary samples, including normal bone marrow (BM) samples and hematopoietic stem and progenitor cells. We analyzed CD 72 expression on a cohort of 495 pathological pediatric BM aspirates, including: 215 B‐cell precursor acute lymphoblastic leukemias (BCP‐ALL), 156 acute myeloid leukemias (AMLs), 88 T‐lineage ALLs or lymphoblastic lymphomas with BM infiltration, 13 B‐lineage lymphoblastic lymphomas with BM infiltration, 9 myelodysplastic syndromes with increased blasts (5%–9% blasts on BM: MDS‐IB1) and 14 non‐hematopoietic solid tumors infiltrating BM. Results showed that CD72 is highly expressed in almost all BCP‐ALL and the majority of AML at diagnosis, including BCP‐ALL cases characterized by CD19 loss. These findings support a potential role for advanced diagnostics and novel immunotherapy approaches, providing a pan‐ALL and AML target. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study

Author

Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, Gerss, Joachim, Möricke, Anja, Zimmermann, Martin, Stary, Jan, Smisek, Petr, Attarbaschi, Andishe, Nath, Christa, Zucchetti, Massimo, Rizzari, Carmelo, Schrappe, Martin, and Boos, Joachim

Published
2020
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43. Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine

Author

Alexander, Sarah Weeks, Apel, Anna, Adyrov, Mykhaylo V, Avula, Meghana, Bal, Wioletta Anna, Balwierz, Walentyna Aniela, Basset-Salom, Luisa, Bastardo Blanco, Daniel, Bauer, Karolina Jadwiga, Bayazitov, Ildar T, Berlanga, Pablo, Bhakta, Nickhill Hitesh, Bieniek, Katarzyna Anna, Bien, Ewa Iwona, Blackwood, Christopher Andrew, Blair, Sally Jane, Bodak, Khrystyna Ihorivna, Bordeianu, Irina, Bouffet, Eric, Braganca, Joao Maria, Bucurenci, Mihaela Silvia, Budny, Elżbieta Beata, Budzyn, Andrii, Bumgardner, Christopher Carl, Burditt, Raina Nichole, Burnside Clapp, Victoria, Bykov, Viacheslav Valeriyovych, Cañete, Adela, Carnelli, Monica, Cela, Elena, Chaber, Radoslaw, Cherner-Drieux, Anna, Chubata, Mariya, Clough, Heidi M, Czauderna, Piotr Stefan, Czernicka - Siwecka, Jolanta, Czyzewski, Krzysztof, Dalle, Jean-Hugues, Dashchakovska, Olha, de Koning, Linda A, Dembowska-Baginska, Bozenna Malgorzata, Derwich, Katarzyna, Dirksen, Uta, Dommett, Rachel, Dorosh, Olha Ihorivna, dos Reis Farinha, Nuno Jorge, Drabko, Katarzyna Anna, Dragomir, Monica Desiree, Dworzak, Michael, Dyma, Sergii Vitaliiovych, Eggert, Angelika, English, Martin William, Farren, Becky S, Fedyk, Nataliia Yuriina, Fernández-Teijeiro, Ana, Ferneza, Severyn Romanovych, Foster, Whitney Baer, Fox Irwin, Leeanna Elizabeth, Gałązkowski, Robert Maciej, Ganieva, Galyna, Garanzha, Vasylyna Andriivna, Gelman, Marina S, Godzinski, Jan Krzysztof, Goeres, Anne Françoise, Golban, Rodica, Graetz, Dylan Elizabeth, Greiner, Jeanette, Griksaitis, Michael J, Gupta, Sumit, Hampel, Michal Andrzej, Hastings, Sara Grace, Heenen, Delphine Liliane, Hill, Marcela C, Holiuk, Ihor, Holter, Wolfgang, Hough, Rachael Emma, Hutnik, Lukasz Marek, Irga-Jaworska, Ninela, Istomin, Oleksandr Andriyovych, Ignatova, Anna, Janczar, Szymon Lech, Kacharian, Arman, Kalwak, Krzysztof, Karolczyk, Grażyna Małgorzata, Karpenko, Nataliia Mikolaivna, Katsubo, Halyna Oleksandrivna, Kattamis, Antonis, Kazanowska, Bernarda Jadwiga, Kentsis, Alex, Ketteler, Petra, Kienesberger, Anita, Kiselev, Roman, Kizyma, Zoryana Petrivna, Klymniuk, Hryhorii Ivanovych, Kolenova, Alexandra, Kostiuk, Yuliia, Kowalik, Tomasz, Kozlova, Olena Igorivna, Kozubenko, Vladyslav, Kraal, Kathelijne, Kramar, Tetyana Oleksandrivna, Krawczuk-Rybak, Maryna Maryna, Kulemzina, Irina, Kurkowska, Paulina, Kuzyk, Andriy S., Ladenstein, Ruth Lydia, Laguna, Pawel Jozef, Lassaletta, Alvaro, Lehmberg, Kai, Leontieva, Oksana, Liashenko, Serhii, Loizou, Loizos G., Lucchetta, Sonia Anna, Lupo, Matthew William, Lysytsia, Lesya, Lysytsia, Oleksandr, Machnik, Katarzyna Anna, Massimino, Maura, Mainland, Jeff A, Matysiak, Michal Jacek, Mayeur, Pierre, Miller, Beth Anne, Minervina, Anastasia A, Mishkova, Volha, Mizia-Malarz, Agnieszka Joanna, Morales La Madrid, Andres, Moreira, Daniel C, Moreno, Lucas, Moskvin, Vadim P, Mukkada, Sheena Teresa, Muszyńska-Rosłan, Katarzyna Maria, Mykychak, Iryna Volodymyrivna, Niemeyer, Charlotte, Nelson, Akoya Janae', Ociepa, Tomasz, Oltolini, Stefano, Onipko, Nataliia, Pappas, Andrew, Patel, Amit B, Patrahau, Alina Alina, Pauley, Jennifer L., Pavlenko, Yehor Mikhailovich, Pavlovych, Andrij Oleksandrovych, Peregud-Pogorzelski, Jarosław Władysław, Perek-Polnik, Marta, Pérez, Vanesa, Pérez-Martínez, Antonio, Pikman, Yana, Pitozzi, Graziano Pitozzi, Portugal, Rui Gentil, Posternak, Victoria Vita, Pleshkan, Viktoriya, Prete, Arcangelo, Pritchard-Jones, Kathy, Radaelli, Alessandra, Reeves, Tegan Jemma, Reinhardt, Dirk, Reshetnyak, Andrey V, Rider, Andrew Jacob, Rizzari, Carmelo, Rizzi, Damiano Damiano, Rodriguez Hermosillo, Karen Gabriela, Ronenko, Olena Volodymyrivna, Rostkowska, Aneta Olga, Rudko, Liudmyla Yaroslavivna, Sakaan, Firas Mohamed, Sakhar, Nadezhda Aleksandrovna, Salman, Zeena S, Savva, Natallia N, Scaccaglia, Davide, Schaeffer, Elizabeth Hawthorne, Schneider, Carina Ursula, Scobie, Nicole, Semeniuk, Olena Volodymyrivna, Shevchyk, Roksoliana, Shuler, Ana, Shvets, Stanislav, Sniderman, Liz, Skoczen, Szymon Pawel, Smeal, William John, Sonkin, Anna Alexandra, Spota, Andrea, Sramkova, Lucie, Stepanjuk, Alla Ivanivna, Sterba, Jaroslav, Strahm, Brigitte, Styczynski, Jan, Svintsova, Olha, Synyuta, Andriy V, Szczepanski, Tomasz, Szczucinski, Paweł Kukiz, Szmyd, Bartosz Miroslaw, Tasso Cereceda, Maria, Teliuk, Alina, Tomanek, Iwona, Topping, Phoebe, Torrent, Montserrat, Trelińska, Joanna, Troyanovska, Olha Orestivna, Tsurkan, Lyudmila G., Tsymbalyuk-Voloshyn, Iryna, Tyupa, Sergiy Ihorovych, Urasinski, Tomasz Franciszek, Urbanek Dądela, Agnieszka, Vasilieva, Nataliia Jroslavivna, Vasilyeva, Aksana, Verdú-Amorós, Jaime, Vilcu-Bajurean, Natalia, Vinitsky, Leo, Vivtcharenko, Victoria, Vovk, Nelia, Volpe, Giovanni, Vorobel, Oksana Ivanivna, Wachowiak, Jacek Tadeusz, Wasiak, Marcin Sławomir, Wiedower, Lance Allan, Wuenschel, Lena Isolde, Wysocki, Mariusz Stanislaw, Yurieva, Marina, Zagurska, Anastasiia, Zakharenko, Stanislav S, Zakharenko, Aelita V, Zapotochna, Khrystyna, Zawitkowska, Joanna Emilia, Zecca, Marco, Salek, Marta, Mueller, Alexandra, Alanbousi, Inna, Cepowska, Zuzanna, Dutkiewicz, Malgorzata, Earl, Julian, Evseev, Dmitry, Kizyma, Roman, Kliuchkivska, Khrystyna, Kolodrubiec, Julia, Matczak, Katarzyna, Nogovitsyna, Yuliya, Oszer, Aleksandra, Pogorelyy, Mikhail, Raciborska, Anna, Rasul, Suheir, Sokolowski, Igor, Sopilnyak, Andriy, Vinitsky, Anna, Wlodarski, Marcin W, Wobst, Natalia, Yakimkova, Taisiya, Rodriguez-Galindo, Carlos, Wise, Paul H, Mlynarski, Wojciech, and Agulnik, Asya

Published
2023
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44. Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Author

Heilmann, Janina, primary, Vieth, Simon, additional, Möricke, Anja, additional, Attarbaschi, Andishe, additional, Barbaric, Draga, additional, Bodmer, Nicole, additional, Colombini, Antonella, additional, Dalla-Pozza, Luciano, additional, Elitzur, Sarah, additional, Izraeli, Shai, additional, Mann, Georg, additional, Niggli, Felix, additional, Silvestri, Daniela, additional, Stary, Jan, additional, Rizzari, Carmelo, additional, Valsecchi, Maria Grazia, additional, Zapotocka, Ester, additional, Zimmermann, Martin, additional, Cario, Gunnar, additional, Schrappe, Martin, additional, and Conter, Valentino, additional

Published
2023
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45. Supplementary Data from Pharmacokinetics of Nilotinib in Pediatric Patients with Philadelphia Chromosome–Positive Chronic Myeloid Leukemia or Acute Lymphoblastic Leukemia

Author

Hijiya, Nobuko, primary, Zwaan, C. Michel, primary, Rizzari, Carmelo, primary, Foà, Robin, primary, Abbink, Floor, primary, Lancaster, Donna, primary, Landman-Parker, Judith, primary, Millot, Frédéric, primary, Moppett, John, primary, Nelken, Brigitte, primary, Caterina Putti, Maria, primary, Tian, Xianbin, primary, Sinclair, Karen, primary, Santanastasio, Helene, primary, Buchbinder, Aby, primary, and Kearns, Pamela, primary

Published
2023
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46. The long-term efficacy and safety of nilotinib in pediatric patients with CML:a 5-year update of the DIALOG study

Author

Hijiya, Nobuko, Maschan, Alexey, Rizzari, Carmelo, Shimada, Hiroyuki, Dufour, Carlo, Goto, Hiroaki, Kang, Hyoung Jin, Guinipero, Terri, Karakas, Zeynep, Bautista, Francisco, Ducassou, Stéphane, Yoo, Keon Hee, Zwaan, Christian Michel, Millot, Frédéric, Patterson, Briana C., Samis, Jill, Izquierdo, Miguel, Titorenko, Ksenia, Li, Sai, Sosothikul, Darintr, Hijiya, Nobuko, Maschan, Alexey, Rizzari, Carmelo, Shimada, Hiroyuki, Dufour, Carlo, Goto, Hiroaki, Kang, Hyoung Jin, Guinipero, Terri, Karakas, Zeynep, Bautista, Francisco, Ducassou, Stéphane, Yoo, Keon Hee, Zwaan, Christian Michel, Millot, Frédéric, Patterson, Briana C., Samis, Jill, Izquierdo, Miguel, Titorenko, Ksenia, Li, Sai, and Sosothikul, Darintr

Abstract

The efficacy and safety of nilotinib in pediatric patients with imatinib/dasatinib resistant/ intolerant (R/I) or newly diagnosed (ND) Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia in chronic phase (CML-CP) was demonstrated in the phase 2, open-label DIALOG study. In this final analysis, long-term efficacy and safety are presented for patients who completed 66 cycles (of 28 days) of treatment with nilotinib (230 mg/m2 twice daily) or discontinued early. Overall, 59 patients were enrolled and 58 were treated (R/I, n = 33; ND, n = 25; median time on treatment: 60.5 and 51.9 months, respectively). In the R/I cohort, the cumulative major molecular response (MMR; BCR::ABL1 international scale [IS] ≤ 0.1%) rate was 60.6%, and no patients had a confirmed loss of MMR. Among ND patients, the best overall MMR rate was 76.0%; 3 patients had a confirmed loss of MMR. The cumulative molecular response MR4 (BCR::ABL1IS ≤ 0.01%) and MR4.5 (BCR::ABL1IS ≤ 0.0032%) rates by 66 cycles were 27.3% and 12.1% in the R/I cohort, and 56.0% and 44.0% in the ND cohort, respectively. The safety profile of nilotinib was consistent with those of earlier reports. No on-treatment deaths occurred. These long-term (up to ~5 years) data support the efficacy and safety of nilotinib in pediatric patients with Ph+ CML-CP. This trial was registered at www.clinicaltrials.gov.uk as #NCT01844765.

Published
2023

47. Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction

Author

Möricke, Anja, Rizzari, Carmelo; https://orcid.org/0000-0002-4828-3893, Alten, Julia, Attarbaschi, Andishe; https://orcid.org/0000-0002-9285-6898, Beier, Rita, Biondi, Andrea; https://orcid.org/0000-0002-6757-6173, Burkhardt, Birgit; https://orcid.org/0000-0002-1151-829X, Bodmer, Nicole, Boos, Joachim, Cario, Gunnar, Conter, Valentino; https://orcid.org/0000-0001-5697-4929, Flotho, Christian, Kulozik, Andreas; https://orcid.org/0000-0003-1953-0848, Lanvers-Kaminsky, Claudia, Mann, Georg, Niggli, Felix; https://orcid.org/0000-0002-7553-3712, Silvestri, Daniela, von Stackelberg, Arend, Stanulla, Martin; https://orcid.org/0000-0002-3834-0727, Valsecchi, Maria-Grazia, Schrappe, Martin; https://orcid.org/0000-0003-0034-5845, Zimmermann, Martin; https://orcid.org/0000-0002-0365-3512, Möricke, Anja, Rizzari, Carmelo; https://orcid.org/0000-0002-4828-3893, Alten, Julia, Attarbaschi, Andishe; https://orcid.org/0000-0002-9285-6898, Beier, Rita, Biondi, Andrea; https://orcid.org/0000-0002-6757-6173, Burkhardt, Birgit; https://orcid.org/0000-0002-1151-829X, Bodmer, Nicole, Boos, Joachim, Cario, Gunnar, Conter, Valentino; https://orcid.org/0000-0001-5697-4929, Flotho, Christian, Kulozik, Andreas; https://orcid.org/0000-0003-1953-0848, Lanvers-Kaminsky, Claudia, Mann, Georg, Niggli, Felix; https://orcid.org/0000-0002-7553-3712, Silvestri, Daniela, von Stackelberg, Arend, Stanulla, Martin; https://orcid.org/0000-0002-3834-0727, Valsecchi, Maria-Grazia, Schrappe, Martin; https://orcid.org/0000-0003-0034-5845, and Zimmermann, Martin; https://orcid.org/0000-0002-0365-3512

Published
2023

48. Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Author

Heilmann, Janina, Vieth, Simon, Möricke, Anja, Attarbaschi, Andishe; https://orcid.org/0000-0002-9285-6898, Barbaric, Draga, Bodmer, Nicole, Colombini, Antonella, Dalla-Pozza, Luciano, Elitzur, Sarah; https://orcid.org/0000-0002-3495-7578, Izraeli, Shai; https://orcid.org/0000-0002-6938-2540, Mann, Georg, Niggli, Felix; https://orcid.org/0000-0002-7553-3712, Silvestri, Daniela, Stary, Jan; https://orcid.org/0000-0002-6818-7743, Rizzari, Carmelo, Valsecchi, Maria Grazia; https://orcid.org/0000-0001-5574-3504, Zapotocka, Ester, Zimmermann, Martin, Cario, Gunnar, Schrappe, Martin; https://orcid.org/0000-0003-0034-5845, Conter, Valentino; https://orcid.org/0000-0001-5697-4929, Heilmann, Janina, Vieth, Simon, Möricke, Anja, Attarbaschi, Andishe; https://orcid.org/0000-0002-9285-6898, Barbaric, Draga, Bodmer, Nicole, Colombini, Antonella, Dalla-Pozza, Luciano, Elitzur, Sarah; https://orcid.org/0000-0002-3495-7578, Izraeli, Shai; https://orcid.org/0000-0002-6938-2540, Mann, Georg, Niggli, Felix; https://orcid.org/0000-0002-7553-3712, Silvestri, Daniela, Stary, Jan; https://orcid.org/0000-0002-6818-7743, Rizzari, Carmelo, Valsecchi, Maria Grazia; https://orcid.org/0000-0001-5574-3504, Zapotocka, Ester, Zimmermann, Martin, Cario, Gunnar, Schrappe, Martin; https://orcid.org/0000-0003-0034-5845, and Conter, Valentino; https://orcid.org/0000-0001-5697-4929

Abstract

Although initial central nervous system (CNS) involvement is rarely detected in childhood acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all patients. Treatment intensity depends on the initial CNS status. In the AIEOP-BFM ALL 2009 trial, patients with cytomorphologic detection of leukemic blasts in initial cerebrospinal fluid were classified as CNS2 or CNS3 and received five intrathecal doses of methotrexate (MTX) in induction therapy compared to patients with CNS1 status (no blasts detected) who received three doses. The impact of additional intrathecal (IT) MTX on systemic toxicity in induction therapy is unknown. Between June 1st 2010 and February 28th 2017, a total of 6,136 ALL patients aged 1-17 years were enrolled onto the AIEOP-BFM ALL 2009 trial. The effect of three versus five doses of IT MTX during induction therapy on the incidence of severe infectious complications was analyzed. Among 4,706 patients treated with three IT MTX doses, 77 (1.6%) had a life-threatening infection during induction as compared to 59 of 1,350 (4.4%) patients treated with five doses (P<0.001; Odds Ratio 2.86 [95% Confidence Interval 1.99-4.13]). In a multivariate regression model, treatment with additional IT MTX proved to be the strongest risk factor for life-threatening infections (Odds Ratio 2.85 [1.96-4.14]). Fatal infections occurred in 16 (0.3%) and 38 (1.6%) patients treated with three or five IT MTX doses, respectively (P<0.001). As the relevance of additional intrathecal MTX in induction for relapse prevention in CNS2 patients is unclear, doses of intrathecal therapy have been reduced for these patients. (Clinicaltrials.gov identifiers: NCT01117441 and NCT00613457).

Published
2023

49. Meeting report of the 1$^{st}$ SIOP Europe Course in Paediatric Oncology: Maasmechelen, Belgium, April 6–9, 2022 – The participants’ view and experience

Author

Morscher, Raphael J; https://orcid.org/0000-0003-3378-9266, Al-Jilaihawi, Sarah, Hamrin, Johan; https://orcid.org/0000-0002-5406-6190, Poyer, Fiona; https://orcid.org/0000-0002-3393-9706, Raja, Raheel Altaf, Rademacher, Annika V, Blondeel, Anne, Essiaf, Samira, Kearns, Pamela, Rizzari, Carmelo, Schoot, Reineke; https://orcid.org/0000-0002-8838-981X, Attarbaschi, Andishe; https://orcid.org/0000-0002-9285-6898, Morscher, Raphael J; https://orcid.org/0000-0003-3378-9266, Al-Jilaihawi, Sarah, Hamrin, Johan; https://orcid.org/0000-0002-5406-6190, Poyer, Fiona; https://orcid.org/0000-0002-3393-9706, Raja, Raheel Altaf, Rademacher, Annika V, Blondeel, Anne, Essiaf, Samira, Kearns, Pamela, Rizzari, Carmelo, Schoot, Reineke; https://orcid.org/0000-0002-8838-981X, and Attarbaschi, Andishe; https://orcid.org/0000-0002-9285-6898

Abstract

More than 35,000 children are diagnosed with cancer and treated in Europe each year. With the 1$^{st}$ SIOP Europe Course in Paediatric Oncology, the European Society for Paediatric Oncology (SIOP Europe) aimed to equip aspiring physicians to become leaders within a pan-European network and ensure state-of-the-art treatment for children across Europe. Fifty participants from 24 countries and 37 centres were enrolled on the course. With a virtual and a face-to-face meeting complete, we herewith report on the course concept, application process and first meetings of this 3-year educational program.

Published
2023

50. Early T-cell precursor acute lymphoblastic leukaemia in children treated in AIEOP centres with AIEOP-BFM protocols: a retrospective analysis

Author

Conter, Valentino, Valsecchi, Maria Grazia, Buldini, Barbara, Parasole, Rosanna, Locatelli, Franco, Colombini, Antonella, Rizzari, Carmelo, Putti, Maria Caterina, Barisone, Elena, Nigro, Luca Lo, Santoro, Nicola, Ziino, Ottavio, Pession, Andrea, Testi, Anna Maria, Micalizzi, Concetta, Casale, Fiorina, Pierani, Paolo, Cesaro, Simone, Cellini, Monica, Silvestri, Daniela, Cazzaniga, Giovanni, Biondi, Andrea, and Basso, Giuseppe

Published
2016
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