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1. Effect of PARACT (PARAmedical Interventions on Patient ACTivation) on the Cancer Care Pathway: Protocol for Implementation of the Patient Activation Measure-13 Item (PAM-13) Version

Author

Verot, Elise, Bouleftour, Wafa, Macron, Corinne, Rivoirard, Romain, and Chauvin, Franck

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundThe increase in the number of cancer cases and the evolution of cancer care management have become a significant problem for the French health care system, thereby making patient empowerment as a long sought-after goal in chronic pathologies. The implementation of an activation measure via the Patient Activation Measure-13 item (PAM-13) in the course of cancer care can potentially highlight the patient’s needs, with nursing care adapting accordingly. ObjectiveThe objectives of this PARACT (PARAmedical Interventions on Patient ACTivation) multicentric study were as follows: (1) evaluate the implementation of PAM-13 in oncology nursing practices in 5 comprehensive cancer centers, (2) identify the obstacles and facilitators to the implementation of PAM-13, and (3) produce recommendations for the dissemination of such interventions in other comprehensive cancer centers. MethodsThis study will follow the “Reach, Effectiveness, Adoption, Implementation, and Maintenance” framework and will consist of 3 stages. First, a robust preimplementation analysis will be conducted using the Theoretical Domains Framework (TDF) linked to the “Capability, Opportunity, Motivation, and Behavior” model to identify the obstacles and facilitators to implementing new nursing practices in each context. Then, using the Behavior Change Wheel, we will personalize a strategy for implementing the PAM-13, depending on the specificities of each context, to encourage acceptability by the nursing staff involved in the project. This analysis will be performed via a qualitative study through semistructured interviews. Second, the patient will be included in the study for 12 months, during which the patient care pathway will be studied, particularly to collect all relevant contacts of oncology nurses and other health professionals involved in the pathway. The axes of nursing care will also be collected. The primary goal is to implement PAM-13. Secondary factors to be measured are the patient’s anxiety level, quality of life, and health literacy level. The oncology nurses will be responsible for completing the questionnaires when the patient is at the hospital for his/her intravenous chemotherapy/immunotherapy treatment. The questionnaires will be completed thrice in a year: (1) at the time of the patient’s enrollment, (2) at 6 months, and (3) at 12 months. Third, a postimplementation analysis will be performed through semistructured interviews using the TDF to investigate the implementation problems at each site. ResultsThis study was supported by a grant from the French Ministry of Health (PHRIP PARACT 2016-0405) and the Lucien Neuwirth Institute of Cancerology of Saint-Etienne, France. Data collection for this study is ongoing. ConclusionsThis study would improve the implemented targeted nursing interventions in cancer centers so that a patient is offered a personalized cancer care pathway. Furthermore, measuring the level of activation and the implementation of measures intended to increase such activation could constitute a significant advantage in reducing social health inequalities. Trial RegistrationClinicalTrials.gov NCT03240341; https://clinicaltrials.gov/ct2/show/NCT03240341 International Registered Report Identifier (IRRID)DERR1-10.2196/17485

Published
2020
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5. Effectiveness of a nurse-led telephone follow-up in the therapeutic management of patients receiving oral antineoplastic agents: a randomized, multicenter controlled trial (ETICCO study)

Author

Bouleftour, Wafa, Muron, Thierry, Guillot, Aline, Tinquaut, Fabien, Rivoirard, Romain, Jacquin, Jean-Philippe, Saban-Roche, Léa, Boussoualim, Karima, Tavernier, Emmanuelle, Augeul-Meunier, Karine, Collard, Olivier, Mery, Benoite, Pupier, Sidonie, Oriol, Mathieu, Bourmaud, Aurélie, Fournel, Pierre, and Vassal, C.

Published
2021
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12. PARP inhibitors (PARPi) prolongation after local therapy for oligo-metastatic progression in relapsed ovarian cancer patients

Author

Gauduchon, Thibault, primary, Kfoury, Maria, additional, Lorusso, Domenica, additional, Floquet, Anne, additional, Ventriglia, Jole, additional, Salaun, Hélène, additional, Moubarak, Malak, additional, Rivoirard, Romain, additional, Polastro, Laura, additional, Favier, Laure, additional, You, Benoit, additional, Berton, Dominique, additional, de la Motte Rouge, Thibault, additional, Mansi, Laura, additional, Abdeddaim, Cyril, additional, Prulhiere, Karine, additional, Lancry Lecomte, Laurence, additional, Provansal, Magali, additional, Dalban, Cécile, additional, and Ray-Coquard, Isabelle, additional

Published
2023
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15. Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

Author

Passot, Guillaume, Kim, Bradford J., Glehen, Olivier, Mehran, Reza J., Kopetz, Scott E., Goere, Diane, Overman, Michael J., Pocard, Marc, Marchal, Frédéric, Conrad, Claudius, Aloia, Thomas A., Vauthey, Jean-Nicolas, Chun, Yun Shin, Abba, Julio, Abboud, Karine, Alyami, Mohammad, Arvieux, Catherine, Asnacios, Amani, Averous, Gerlinde, Bakrin, Naoual, Bardier, Armelle, Rejeb, Houda Ben, Bereder, Jean-Marc, Bernard, Jean-Louis, Bibeau, Frédéric, Bonnefoy, Isabelle, Borg, Christophe, Boschetti, Gilles, Bouarioua, Nadia, Bouche, Olivier, Bouzard, Dominique, Brigand, Cécile, Cacheux, Wulfran, Capitain, Olivier, Carrère, Sébastien, Carretier, Michel, Castel, Benjamin, Chauvenet, Marion, Chevallier, Anne, Coffin, Benoît, Costan, Cristina, Cotte, Eddy, Courvoisier, Thomas, Dahan, Laetitia, Dartigues, Peggy, De Chaisemartin, Cécile, Dechelotte, Pierre, Deguelte-Lardière, Sophie, Delpero, Jean-Robert, Del Grande, Jean, Demarchi, Martin, Desandes, Emmanuel, Desolneux, Grégoire, Dufour, Patrick, Dumont, Frédéric, Durand-Fontanier, Sylvaine, Eveno, Clarisse, Evrard, Serge, Facy, Olivier, Farkhondeh, Fereshteh, Fontaine, Juliette, Gagniere, Johan, Galais, Marie-Pierre, Ghouti, Laurent, Gilly, François-Noël, Goasguen, Nicolas, Gornet, Jean-Marc, Gourdiole, Pierre, Guerin-Meyer, Véronique, Guilloit, Jean-Marc, Guimbaud, Rosine, Guyon, Frédéric, Heyd, Bruno, Heymann, Marie-Françoise, Isaac, Sylvie, Jouet, Pauline, Jourdan-Enfer, Peggy, Jouve, Jean-Louis, Kaci, Rachid, Karoui, Mehdi, Kianmanesh, Reza, Kirzin, Sylvain, Kurtz, Jean-Emmanuel, Labrousse, François, Lebrun-Ly, Valérie, Lefevre, Jérémie, Lelong, Bernard, Lemaistre, Anne-Elisabeth, Leroux-Broussier, Agnès, Levillain, Pierre, Linot, Benjamin, Dico, Réa Lo, Loi, Valéria, Lorimier, Gérard, Mahammat, Abakar, Malka, David, Marchal, Frédéric, Mariani, Antoine, Mariani, Pascale, Mariette, Christophe, Martin, Laurent, Meeus, Pierre, Meffert, Jean-Luc, Messager, Mathieu, Michel, Pierre, Msika, Simon, Muron, Thierry, Noel, Georges, Ortega-Deballon, Pablo, Paquette, Brice, Peoc’h, Michel, Petorin, Caroline, Peyrat, Patrice, Pezet, Denis, Piessen, Guillaume, Pirro, Nicolas, Pocard, Marc, Poizat, Flora, Porcheron, Jack, Poulet, Anaïs, Portales, Fabienne, la Denise, Justine Prost a, Quenet, François, Rat, Patrick, Rebischung, Christine, Regimbeau, Jean-Marc, Rivoirard, Romain, Rohr, Serge, Rougier, Philippe, Rousselot, Pierre, Saban-Roche, Léa, Sabate, Jean-Marc, Sabbagh, Charles, Sabourin, Jean-Christophe, Samalin-Scalzi, Emmanuelle, Seitz, Jean-François, Selves, Janick, Senellart, Helène, Serrano, Martine, Sgabura, Olivia, Sielezneff, Igor, Svrcek, Magali, Taibi, Abdelkader, Taieb, Julien, Thibaudeau, Emilie, Tougeron, David, Tuech, Jean-Jacques, Valmary-Degano, Séverine, Vaudoyer, Delphine, Verriele-Beurrier, Véronique, Villeneuve, Laurent, Volet, Julien, Wernert, Romuald, Ychou, Marc, You, Benoît, Zaanan, Aziz, Zinzindohoue, Franck, and on behalf of the BIG-RENAPE Working Group

Published
2017
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17. T2‐Fluid‐attenuated inversion recovery (FLAIR) pseudoprogression in patients with anaplastic oligodendrogliomas treated with procarbazine, lomustine and vincristine (PCV) chemotherapy alone.

Author

Esparragosa Vazquez, Inés, Ndiaye, Mané, Di Stefano, Anna Luisa, Younan, Nadia, Larrieu‐Ciron, Delphine, Seyve, Antoine, Picart, Thiébaud, Meyronet, David, Boutet, Claire, Vassal, François, Carpentier, Catherine, Figarella‐Branger, Dominique, Dehais, Caroline, Forest, Fabien, Rivoirard, Romain, and Ducray, François

Subjects
POSITRON emission tomography, OLIGODENDROGLIOMAS, ADJUVANT chemotherapy, DIFFUSION magnetic resonance imaging, MAGNETIC resonance imaging, CONTRAST-enhanced magnetic resonance imaging
Abstract

Background: Pseudoprogression in gliomas has been extensively described after radiotherapy with or without chemotherapy, but not after chemotherapy alone. Here we describe the occurrence of pseudoprogression in patients with anaplastic oligodendrogliomas treated with postoperative procarbazine, lomustine and vincristine (PCV) chemotherapy alone. Methods: We retrospectively reviewed the medical and radiological files of patients with 1p/19q codeleted, IDH‐mutant anaplastic oligodendrogliomas treated with PCV chemotherapy alone who presented magnetic resonance imaging (MRI) modifications suggestive of tumour progression and in whom the final diagnosis was a pseudoprogression. Results: We identified six patients. All patients underwent a surgical resection and were treated with PCV chemotherapy without radiotherapy. After a median of 11 months following the initiation of chemotherapy (range: 3–49 months), the patients developed asymptomatic white matter MRI modifications around the surgical cavity leading to the suspicion of a tumour progression. These modifications appeared as hyperintense on T2‐fluid‐attenuated inversion recovery (FLAIR) sequence, hypointense on T1 sequence, and lacked mass effect (0/6), contrast enhancement (0/6), restriction on diffusion‐weighted imaging (0/4), relative cerebral blood volume (rCBV) increase on perfusion MRI (0/4), and hypermetabolism on 18F‐fluoro‐L‐dopa positron emission tomography (18F‐DOPA PET) scan (0/3). One patient underwent a surgical resection demonstrating no tumour recurrence; the five other patients were considered as having post‐therapeutic modifications based on imaging characteristics. After a median follow‐up of 4 years all patients were progression‐free. Conclusions: Anaplastic oligodendroglioma patients treated with postoperative PCV chemotherapy alone occasionally develop T2/FLAIR hyperintensities around the surgical cavity that can wrongly suggest tumour progression. Multimodal imaging and close follow‐up should be considered in this situation. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Lièvre, Astrid, primary, Turpin, Anthony, additional, Ray-Coquard, Isabelle, additional, Le Malicot, Karine, additional, Thariat, Juliette, additional, Ahle, Guido, additional, Neuzillet, Cindy, additional, Paoletti, Xavier, additional, Bouché, Olivier, additional, Aldabbagh, Kais, additional, Michel, Pierre, additional, Debieuvre, Didier, additional, Canellas, Anthony, additional, Wislez, Marie, additional, Laurent, Lucie, additional, Mabro, May, additional, Colle, Raphael, additional, Hardy-Bessard, Anne-Claire, additional, Mansi, Laura, additional, Colomba, Emeline, additional, Bourhis, Jean, additional, Gorphe, Philippe, additional, Pointreau, Yoann, additional, Idbaih, Ahmed, additional, Ursu, Renata, additional, Di Stefano, Anna Luisa, additional, Zalcman, Gérard, additional, Aparicio, Thomas, additional, Moulin, Solenne, additional, Leleu, Olivier, additional, Leparree, Sylvie, additional, Goasdoue, Henri, additional, Piprot, Christine, additional, Tourneur, Gerald, additional, Bayart, Vincent, additional, Lignier, Delphine, additional, Lachaier, Emma, additional, Khamari, Marwa, additional, Coutte, Alexandre, additional, Siembida, Nicolas, additional, Houessinon, Aline, additional, Regimbeau, Jean Marc, additional, Chauffert, Bruno, additional, Moreira, Aurélie, additional, Hautefeuille, Vincent, additional, Hee, Christine, additional, Boone, Mathieu, additional, Bihan, Céline, additional, Chive, Emilie, additional, Poulet-Potriquier, Stéphane, additional, Fahem, Rachida, additional, Luet, Dominique, additional, Roquin, Guillaume, additional, Vitellius, Carole, additional, Cornet-Trichereau, Nathanaëlle, additional, Caroli-Bosc, François-Xavier, additional, Thirot-Bidault, Anne, additional, Ropert, Stanislas, additional, Gachet - Masson, Julie, additional, Dehais, Mélanie, additional, L'helgoualc'h, Gwen-Ael, additional, Ali-Mahamadou, Ibrahim, additional, Talfi, Safia, additional, Belmont, Laure, additional, Kilendo, Dieudonné, additional, Benrezzak, Nasro, additional, Dubief, Emeline, additional, Conroy, Guillaume, additional, Delique, Laurence, additional, Basso, Maud, additional, Pons, Isabelle, additional, Salignon, Karine, additional, Villing, Anne-Laure, additional, Mougenot, Emmanuelle, additional, Porebski, Cassandra, additional, Guiatni, Asma, additional, Cloarec, Nicolas, additional, Mineur, Laurent, additional, Bouchaud, Marie, additional, David, Céleste, additional, Peytier, Annie, additional, Greletty, Thomas, additional, Audemar, Franck, additional, Vignes, Emanuelle, additional, Minne, Floriane, additional, Goldzak, Guillaume, additional, Huysman, Fabienne, additional, Hocine, Fayçal, additional, Lakkis, Zaher, additional, Meynard, Guillaume, additional, Almotlak, Hamadi, additional, Klajer, Elodie, additional, Sun, Xu-Shan, additional, Wasselin, Julie, additional, Catala, Pascale, additional, Mazuy, Claire, additional, Vandamme, Hélène, additional, Prevost, Jean-Briac, additional, Fadin, Aurélie, additional, Basson, Laurent, additional, Huguet, Jean-Baptiste, additional, Dos Santos, Emmanuelle, additional, Jany, Bérangère, additional, Saad, Alain, additional, Goutorbe, Frédéric, additional, Oziol, Eric, additional, Ramdani, Mohamed, additional, Kadiri, Ouafae, additional, Garbay, Delphine, additional, Huet, Clotilde, additional, Giroux Leprieur, Etienne, additional, Teng, Wen, additional, Monvoisin, Justine, additional, Arnaud Coffin, Patrick, additional, Roux, Sylvie, additional, Orfeuvre, Hubert, additional, Chagros, Mélanie, additional, Pillon, Didier, additional, Rassoul, Agathe, additional, Poureau, Pierre Guillaume, additional, Novello, Cécile, additional, Ducray, François, additional, Trouba, Cécile, additional, Bastit, Vianney, additional, Babin, Emmanuel, additional, Leon, Vincent, additional, Courtecuisse, Anne-Catherine, additional, Vambre, Julie, additional, Tack, Vincent, additional, Desauw, Christophe, additional, Meniai, Fatima, additional, Peres, Christina, additional, Esparcieux, Aurélie, additional, Perrier, Hervé, additional, Doux, Nathalie, additional, Kaphan, Régis, additional, Roques, Bertrand, additional, Rebischung, Christine, additional, Mille, Dominique, additional, Fernandes, Gaëlle, additional, Abdelli, Naceur, additional, Jousset, Natacha, additional, Combe, Pierre, additional, Jonveaux, Eric, additional, Dumont, Patrick, additional, Kanaan, Marc, additional, Berthelot Gras, Corinne, additional, Panis, Valérie, additional, Kaluzinski, Laure, additional, Venant-Valery, Marjolène, additional, Lam, You-Heng, additional, Vallee, Laura, additional, Riviere, Frédéric, additional, Durand, Muriel, additional, Benghadid, Dihya, additional, Villeneuve, Emilie, additional, Hentic Dhome, Olivia, additional, Bounouar, Zedjiga, additional, De Mestier, Louis, additional, Dubois, Jacqueline, additional, Eyriey, Magali, additional, Moreau, Lionel, additional, Baihas, Dib, additional, Aldabbagh, Kaïs, additional, Degriffolet, Dominique, additional, Sebbagh, Virginie, additional, Seghezzi, Jean-Christophe, additional, Lozach-Brugirard, Marion, additional, Mandrou, Julie, additional, Mavier, Loubna, additional, Hennetier, Florence, additional, Wagner, Jean-Philippe, additional, Carola, Elisabeth, additional, Chandirakumaran, Karthiga, additional, Loutski, Sandrine, additional, Cojean-Zelek, Isabelle, additional, Bouras, Amina, additional, Lacour, Sandrine, additional, Froura, Fahem, additional, Ben Nadji, Hadjer, additional, Cattelain, Sophie, additional, Darloy, Franck, additional, Jolimoy Boilleau, Geneviève, additional, Maissiat, Cyrielle, additional, Darut-Jouve, Ariane, additional, Lorgis, Véronique, additional, Charifi-Alaoui, Ikram, additional, Ghiringhelli, François, additional, Drouillard, Antoine, additional, Chaix, Marie, additional, Manfredi, Sylvain, additional, Lepage, Côme, additional, Gagnaire, Alice, additional, Latournerie, Marianne, additional, jourdan, Sofia, additional, Perrot, Nora, additional, folia, Mireille, additional, Minello, Anne, additional, Jouve, Jean-Louis, additional, Fery, Marielle, additional, Landau, Alain, additional, Evrard, Diane, additional, Valenza, Bruno, additional, Paitel, Jean-François, additional, Chablais, Laetitia, additional, Kreitmann, Thomas, additional, Lancry-Lecomte, Laurence, additional, Monard, Adrien, additional, Faugeras, Eve, additional, Boucheret, Paul, additional, Glommeau, Cécile, additional, Tchikladze, Christine, additional, Garnier Tixidre, Claire, additional, Long, Jérôme, additional, Zaidi, Manel, additional, Delabarre, Véronique, additional, Meyzenc, Juliette, additional, Ferrand, Loïc, additional, Moro-Sibilot, Denis, additional, Bouheret, Paul, additional, Leyronnas, Cécile, additional, Herve, Camille, additional, Thoor, Audrey, additional, Jacquet, Emanuelle, additional, Roth, Gaël, additional, Madapathage-Senanyake, Videsheka, additional, Chupeau, Peggy, additional, Bieber, Elsa, additional, Rosso, Maud, additional, Lepage, Isabelle, additional, Priou, Frank, additional, Laly, Margot, additional, Aprelon, Sylvie, additional, Sobolak, Natacha, additional, Homokos, Helen, additional, Watelle, Fabienne, additional, Pham-Becker, Alice, additional, Lauridant, Géraldine, additional, Dujardin, Charlotte, additional, Lenglin, Etienne, additional, Nienguet Tsota, Aimée, additional, Dominguez, Sophie, additional, Forestier, Alexandra, additional, Nouvel, Franck, additional, Lerooy, Justine, additional, Ratajczak, Céline, additional, Romano, Olivier, additional, Brzyski, Dorothéee, additional, Barriere, Aurélien, additional, Genet, Dominique, additional, Tisse, Julien, additional, Zasadny, Xavier, additional, Grelet, Adeline, additional, Hennion-Imbault, Amélie, additional, Haustraete, Eglantine, additional, Louafi, Samy, additional, Awad, Manal, additional, Zekri, Younes, additional, Cheneau, Caroline, additional, Leissen, Nolwen, additional, Egreteau, Joëlle, additional, Breant, Alexandra, additional, Sarabi, Matthieu, additional, Labonne, Stéphanie, additional, Forestier, Julien, additional, Leclercq, Céline, additional, Prunier-Bossion, Florence, additional, Ray Coquard, Isabelle, additional, Guillet, Marielle, additional, Theillaumas, Aurélie, additional, Prome, Emilie, additional, Walter, Thomas, additional, Philouze, Pierre, additional, Lawo, Melody, additional, De Talhouet, Solène, additional, Beuvelot, Johanne, additional, Molin, Yann, additional, Bellecoste Martin, Marie, additional, Saussereau, Maud, additional, Agnelli, Lauren, additional, Fakhry, Nicolas, additional, Laplace, Christophe, additional, Norguet Monnereau, Emmanuelle, additional, Boucard, Céline, additional, Djenad, Kahina, additional, Fontaine, Catherine, additional, Seitz, Jean-François, additional, Dahan, Laétitia, additional, Sigrand, Julie, additional, Duluc, Muriel, additional, Locher, Christophe, additional, Fleury, Marjory, additional, Brou Marie, Ange, additional, Berkane, Ramdane, additional, Poupblanc, Séverine, additional, Auby, Dominique, additional, Petran, Daniela, additional, Texereau, Patrick, additional, Guerineau, Elodie, additional, Andre, Morgan, additional, Mahjoubi, Linda, additional, Sarrazin, Fanny, additional, Jeanson, Sonia, additional, Gschwend, Anthony, additional, Birr, Virginie, additional, Fore, Mathieu, additional, Noirclerc, Monique, additional, Dahou, Sihem, additional, Spaeth, Dominique, additional, Lambotin, Mélanie, additional, Lelu, Thomas, additional, Linot, Benjamin, additional, Hugon, Nathalie, additional, Rousseau, Dominique, additional, Castanie, Hélène, additional, Lenne, Carole, additional, Lortholary, Alain, additional, Cessot, Anatole, additional, Merzoug, Messaouda, additional, Naudin, Cécile, additional, Vannetzel, Jean-Michel, additional, Aziz, Ghina, additional, Hadj Arab, Yacine, additional, Pernes, Stéphanie, additional, Roche-Lachaise, Isabelle, additional, Fiteni, Frédéric, additional, Yahiaoui, Hadjer, additional, Marel Lopez, Gwendoline, additional, Oddoz, Jeanne, additional, Peira, Fabienne, additional, Michel, Olivier, additional, Meunier, Jérôme, additional, Ouahrani, Brahim, additional, Roger, Antoine, additional, Branco, Sonia, additional, Nguyen, Van, additional, Gisselbrecht, Mathilde, additional, Hammad, Ghania, additional, Mordant, Pierre, additional, Stroksztejn, Magda, additional, Pocard, Marc, additional, Nlo Meyengue, Luc, additional, Sacco, Emmanuelle, additional, Simon Anne, Sophie, additional, Fabre-Guillevin, Elizabeth, additional, Slim, Marine, additional, Zaanan, Aziz, additional, Cadranel, Jacques, additional, Pluvy, Johan, additional, Ursu, Rénata, additional, Geraldo, Amyrath, additional, Lihi, Rime, additional, Vo, Maryline, additional, Brouk, Zohra, additional, Colle, Raphaël, additional, Bennamoun, Mostefa, additional, Lacan, Fabrice, additional, Louvet, Christophe, additional, Mebarki, Soraya, additional, Veyri, Marianne, additional, Paillaud, Elena, additional, Lucas, Christelle, additional, Dubreuil, Olivier, additional, Lyamani, Jamila, additional, Agguini, Hanane, additional, Soularue, Emilie, additional, Jourdaine, Clément, additional, Verillaud, Benjamin, additional, Herzine, Hakima, additional, Raymond, Eric, additional, Mathiot, Nathalie, additional, Palmieri, Lola Jade, additional, Epanya, Christian, additional, Taieb, Julien, additional, Bertrand, Eliane, additional, Goujon, Gaël, additional, Namour, Céline, additional, Gazeau, Benoit, additional, Zafirova, Biljana, additional, Mirghani, Haitham, additional, Belin, Catherine, additional, Belkhir, Kahina, additional, Gharib, Myriam, additional, Vozy, Aurore, additional, Amrane, Karim, additional, Spano, Jean-Philippe, additional, Wassermann, Johanna, additional, Feuvret, Loic, additional, Bachet, Jean-Baptiste, additional, Philonenko, Sara, additional, Guillot, Laetitia, additional, Zabbe, Marion, additional, Gibiat, Stéphanie, additional, Baylot, Camille, additional, Jouinot, Aude, additional, Leduc, Nicolas, additional, Vieillot, Sabine, additional, James, Laurie, additional, Ducerf, Camille, additional, Blanc, Jean-Frédéric, additional, Falandry Leger, Claire, additional, Wautot, Virginie, additional, Chauvenet, Marion, additional, Vincent, Aude, additional, Tougeron, David, additional, Goulvent, Sandrine, additional, Suc, Etienne, additional, Laurenty, Anne-Pascale, additional, Marquis, Eric, additional, Bonnaire, Margaux, additional, Dewolf, Maxime, additional, Brenet, Esteban, additional, Billard, Delphine, additional, Litre, Claude-Fabien, additional, Dumazet, Antoine, additional, Botsen, Damien, additional, Vazel, Marion, additional, Carlier, Claire, additional, Bonnerave, David, additional, Marchand-Crety, Charles, additional, Bouche, Olivier, additional, Fosse, Patricia, additional, Sefrioui, David, additional, Watson, Sarah, additional, Torche, Fatah, additional, Muron, Thierry, additional, Natur, Stéphane, additional, Desgrippes, Romain, additional, Bihel, Véronique, additional, Ferrand, François-Régis, additional, Leiterer, Caroline, additional, Lavole, Julie, additional, Moquet, Claire, additional, Pressoir, Nathalie, additional, Dziukala, Catherine, additional, Ligeza Poisson, Catherine, additional, Naji, Abdelhalim, additional, Williet, Nicolas, additional, Phelip, Jean-Marc, additional, Di Palma, Fabrice, additional, Kherrour Mehdi, Amina, additional, Langrand-Escure, Julien, additional, Fournel, Pierre, additional, Pigne, Grégoire, additional, Saban-Roche, Léa, additional, Magne, Nicolas, additional, Vassal, Cécile, additional, Jacquin, Jean-Philippe, additional, Ramirez, Carole, additional, Vallard, Alexis, additional, Collard, Olivier, additional, Rivoirard, Romain, additional, Graber, Ivan, additional, Trager Maury, Stéphanie, additional, Duboisset, Elodie, additional, Ayllon Ugarte, Jorge, additional, Rami, Dalilia, additional, Saler, Christine, additional, Reinbolt, Manon, additional, Le Fevre, Clara, additional, Ben Abdelghani, Meher, additional, Dourthe, Louis-Marie, additional, Perruisseau-Carrier, Joffrey, additional, Nguimpi-Tambou, Marlène, additional, Barret, Flavie, additional, Di Stefano Anna, Luisa, additional, Balthazard, Annie, additional, Vassord-Dang, Camille, additional, Le Marchand, Mathilde, additional, Vergniol, Julien, additional, Pripon, Iulia, additional, Daemaegdt, Axelle, additional, Latry, Vanessa, additional, Larrieu, Muna, additional, Landry, Gaëlle, additional, Touihri Maximin, Laetitia, additional, Del Piano, Francesco, additional, Barlet, Agnès, additional, Vernisse, Mylène, additional, Lafond, Sophie, additional, Genin, Charline, additional, Sibertin-Blanc, Camille, additional, Chabrillac, Emilien, additional, Gregoire, Caroline, additional, Vergez, Sébastien, additional, Panouille, Quentin, additional, Guimbaud, Rosine, additional, Richa, Floriane, additional, Lebellec, Loïc, additional, Gounin, Sophie, additional, Buiret, Guillaume, additional, Baudin, Marine, additional, Hamon, Hervé, additional, Deshorgue, Anne-Claire, additional, Barrascout, Eduardo, additional, Legrand, Stéphanie, additional, Houlze, Morgane, additional, Cambula, Linda, additional, Lopez, Anthony, additional, Fouquet, Guillaume, additional, Touabi, Kahina, additional, GermaIn, Adeline, additional, Godbert, Benoit, additional, Voivret, Florence, additional, Perrin, Julie, additional, Da Silva, Rosa, additional, and Bernichon, Emilie, additional

Published
2020
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24. Methodology and quality of reporting of oncology studies (Phase II trials, observational studies)

Author

Rivoirard, Romain, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université de Lyon, Franck Chauvin, Aurélie Bourmaud, and STAR, ABES

Subjects
Literature review, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Méthodologie, Oncology, Reporting, Revue de la littérature, Essai de phase II, Methodology, Oncologie, Phase II trial, Observational studies, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Etudes observationnelles
Abstract

Cancer remains a major public health problem in France : This pathology is the leading cause of death, with nearly 150,000 deaths each year. In order to fight against this disease, the 2014-2019 French cancer plan set the goal of developing clinical research, including at least 50,000 patients per year in 2019 in therapeutic trials. Clinical research in oncology has been booming since the advent of therapies such as targeted molecular therapies or immunotherapy. The number of new drugs being developed in oncology has increased exponentially since the 2000s, resulting in a significant increase in the number of oncology study publications. The analysis of a study is possible only if its experimental design, its realization and its conditions of analysis are clearly described in the published article. Reporting is the process of describing in a publication all the actions, including methodological ones, carried out during the study. 5 systematic reviews were conducted to analyze the reporting of oncology study articles. The first study showed that the literature was poor in articles analyzing the reporting of observational studies (2% of publications) and that the intrinsic reporting of recent systematic reviews on the subject was exhaustive (average OQSR score (2010-2014) = 10, standard deviation = 2). 826 articles of study were analyzed in the second systematic review, 84.5% of which were observational studies. The reporting of the variables and the primary endpoint were clear in 100% and 85.2% of the cases, respectively. A reporting discrepancy for the main statistical test used, between the Methods and Results parts, was identified in 23 articles. The third systematic review revealed a lack of data on the reporting of phase II trials in oncology (13 articles) and 3 reporting evaluation scores were described: OQS, KMS and quality index score. 557 phase II trial publications were reviewed in the fourth systematic review. The KMS reporting score was 0, 1, 2, 3 respectively for 3.9%, 21.4%, 48.5% and 26.2% publications. In multivariate analysis, the 3 variables associated with the KMS score were : Reporting of a clear statistical design (OR = 2.22, 95% CI [1.36-3.65], p, Le cancer demeure en France un problème majeur de santé publique : Cette pathologie reste la principale cause de mortalité, avec près de 150 000 décès chaque année. Afin de lutter contre cette maladie, le plan cancer 2014-2019 a posé comme objectif de développer la recherche clinique, en incluant dès 2019 au moins 50 000 patients par an dans des essais thérapeutiques. La recherche clinique en oncologie est en plein essor depuis l’avènement de thérapies telles que les thérapies moléculaires ciblées ou l’immunothérapie. Le nombre de nouveaux médicaments en développement en oncologie a augmenté de façon exponentielle depuis les années 2000. Il en découle un accroissement important du nombre de publications d’études en oncologie. L’analyse d’une étude n’est possible que si son schéma expérimental, sa réalisation et ses conditions d’analyse sont clairement décrits dans l’article publié. Le reporting est le fait de décrire dans une publication toutes les actions, notamment d’ordre méthodologiques, réalisées au cours de l’étude. 5 revues systématiques de la littérature ont été réalisées afin d’analyser le reporting des articles d’études en oncologie. La première étude a objectivé que la littérature était pauvre en articles analysant le reporting des études observationnelles (2% des publications) et que le reporting intrinsèque des revues systématiques récentes portant sur le sujet était exhaustif (score OQSR moyen (2010-2014) = 10, écart-type =2). 826 articles d’études ont été analysés dans la deuxième revue systématique, dont 84.5% d’études observationnelles. Les reporting des variables et du critère de jugement principal étaient clairs, respectivement dans 100% et 85.2% des cas. Une discordance de reporting pour le test statistique principal utilisé, entre les parties Méthodes et Résultats, a été identifié dans 23 articles. La troisième revue systématique a mis un évidence un manque de données sur le reporting des essais de phase II en oncologie (13 articles) et 3 scores d’évaluation du reporting avaient été décrits : score OQS, score KMS et score d’index de qualité. 557 publications d’essais de phase II ont été étudiées dans la quatrième revue systématique. Le score de reporting KMS était égal à 0, 1, 2, 3 respectivement pour 3,9%, 21,4%, 48,5% et 26,2% articles. En analyse multivariée, les 3 variables associées à la valeur du score KMS étaient : Le reporting clair du design statistique (OR = 2.22; IC 95% [1.36-3.65] ; p

Published
2019

28. Cancer patients treated with intravenous chemotherapy for the first time. What are their needs? What do they lack? A qualitative–quantitative mixed approach

Author

Garcia,Max-Adrien, Kalecinski,Julie, Oriol,Mathieu, Bonne,Armand, Lofti,Mohamed, Espenel,Sophie, Tinquaut,Fabien, Fournel,Pierre, Collard,Olivier, Vassal,Cécile, Rivoirard,Romain, Regnier,Véronique, Chauvin,Franck, Bourmaud,Aurélie, Garcia,Max-Adrien, Kalecinski,Julie, Oriol,Mathieu, Bonne,Armand, Lofti,Mohamed, Espenel,Sophie, Tinquaut,Fabien, Fournel,Pierre, Collard,Olivier, Vassal,Cécile, Rivoirard,Romain, Regnier,Véronique, Chauvin,Franck, and Bourmaud,Aurélie

Abstract

Max-Adrien Garcia,1 Julie Kalecinski,1 Mathieu Oriol,1,2 Armand Bonne,1 Mohamed Lofti,1 Sophie Espenel,3 Fabien Tinquaut,1 Pierre Fournel,4 Olivier Collard,4 Cécile Vassal,4 Romain Rivoirard,4 Véronique Regnier,1,5 Franck Chauvin,1,2,5 Aurélie Bourmaud1,5 1Hygee Center, Lucien Neuwirth Cancer Institut, INSERM – CIC-EC, CIC 1408, Saint Priest en Jarez, France; 2Jean Monnet University, Saint Etienne, France; 3Radiotherapy Department, Lucien Neuwirth Cancer Institut, Saint Priest en Jarez, France; 4Medical Oncology Department, Lucien Neuwirth Cancer Institut, Saint Priest en Jarez, France; 5Quality Safety Performance in Health (HESPER) EA7425, Lyon 1 University, Lyon, France Introduction: The announcement of cancer coupled with initiation of its treatment impacts patients’ psychological and physical states as well as their lifestyles. The objective of this study was to identify and confirm the needs of patients starting off on anticancer chemotherapy treatment. Methods: This study was based on a qualitative–quantitative mixed method. In 2009, a qualitative study was conducted at the Lucien Neuwirth Cancer Institut for cancer patients undergoing intravenous chemotherapy for the first time. Exploratory and semi-directed interviews were carried out by a sociologist. In 2014, a questionnaire was hetero-administered to 100 patients starting off on chemotherapy. Results: Forty patients were interviewed in 2009. Ninety-seven patients answered the questionnaire in 2014. Food was a theme that was identified by a majority of patients in 2009 (13/40) and confirmed in 2014: 63% needed help in identifying favorable food and 67% in identifying those that had to be avoided. The other needs identified were those linked to better understanding of the treatment, of how it may affect the couple, its side effects, hygiene and beauty, and knowledge about other treatments. These needs were confirmed in 2014. New needs were elici

Published
2018

31. Cancer patients treated with intravenous chemotherapy for the first time. What are their needs? What do they lack? A qualitative–quantitative mixed approach

Author

Garcia, Max-Adrien, primary, Kalecinski, Julie, additional, Oriol, Mathieu, additional, Bonne, Armand, additional, Lofti, Mohamed, additional, Espenel, Sophie, additional, Tinquaut, Fabien, additional, Fournel, Pierre, additional, Collard, Olivier, additional, Vassal, Cécile, additional, Rivoirard, Romain, additional, Regnier, Véronique, additional, Chauvin, Franck, additional, and Bourmaud, Aurélie, additional

Published
2018
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33. A retrospective survey of the last 3�months of life in patients carrying glioblastoma: Clinical treatments and profiles

Author

Rivoirard, Romain, primary, Vallard, Alexis, additional, Boutet, Claire, additional, Falk, Alexander, additional, Garin, Clemence, additional, Adjabi, Anissa, additional, Hoarau, Delphine, additional, Forest, Fabien, additional, Fotso, Marie‑Jeannette, additional, Rancoule, Chloe, additional, and Magn�, Nicolas, additional

Published
2017
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34. Personnes âgées et radiothérapie : une synthèse de la littérature

Author

Vallard, Alexis, Guy, Jean-Baptiste, Espenel, Sophie, Langrand-Escure, Julien, Trone, Jane-Chloé, Méry, Benoîte, Moriceau, Guillaume, Rivoirard, Romain, de Laroche, Guy, Chargari, Cyrus, and Magné, Nicolas

Abstract

Le vieillissement de la population française impose aux radiothérapeutes le défi de traiter des patients de plus en plus âgés et ainsi d’adapter leur traitement. Inenvisageable il y a 30ans, la radiothérapie concerne aussi aujourd’hui des patients âgés de plus de 90ans. Des outils d’évaluation oncogériatrique se sont développés ces dernières années, sans pour autant totalement changer, en pratique, les décisions thérapeutiques : si l’évaluation oncogériatrique influence la décision finale de RCP, elle ne définit pas de nouveaux volumes cibles, de nouvelles doses, ou des fractionnements différents. Hormis quelques localisations, il n’existe actuellement aucun consensus sur les traitements adaptés à la population gériatrique, ce qui complique la prise en charge. La présente revue a pour objectif de réaliser un tour d’horizon des publications étudiant l’efficacité et la tolérance de la radiothérapie chez le sujet âgé (>70ans) ou très âgé (>90ans).

Published
2024
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37. Prédiction de la gravité des neutropénies fébriles par le score de MASCC : une étude de cohorte rétrospective

Author

Cervetti, Louise, primary, Vallard, Alexis, additional, Le Moulec, Sylvestre, additional, Espenel, Sophie, additional, Falk, Alexander Tuan, additional, Ben Mrad, Majed, additional, Guy, Jean-Baptiste, additional, Diao, Peng, additional, Méry, Benoîte, additional, Langrand-Escure, Julien, additional, Ferrand, François-Régis, additional, Rivoirard, Romain, additional, Ceccaldi, Bernard, additional, Védrine, Lionel, additional, Magné, Nicolas, additional, and Chargari, Cyrus, additional

Published
2016
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38. Safety assessment of molecular targeted therapies in association with radiotherapy in metastatic renal cell carcinoma

Author

Langrand-Escure, Julien, primary, Vallard, Alexis, additional, Rivoirard, Romain, additional, Méry, Benoîte, additional, Guy, Jean-Baptiste, additional, Espenel, Sophie, additional, Trone, Jane-Chloé, additional, Ben Mrad, Majed, additional, Diao, Peng, additional, Rancoule, Chloé, additional, Suchaud, Jean-Philippe, additional, Fournel, Pierre, additional, Guillot, Aline, additional, Chargari, Cyrus, additional, Escudier, Bernard, additional, Négrier, Sylvie, additional, and Magné, Nicolas, additional

Published
2016
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39. Radiotherapy for gynecologic cancer in nonagenarian patients: a framework for new paradigms

Author

Méry, Benoîte, primary, Ndong, Sylvie Mengue, additional, Guy, Jean-Baptiste, additional, Assouline, Avi, additional, Falk, Alexander T., additional, Valeille, Anaïs, additional, Trone, Jane-Chloé, additional, Rivoirard, Romain, additional, Auberdiac, Pierre, additional, Vallard, Alexis, additional, Espenel, Sophie, additional, Moriceau, Guillaume, additional, Collard, Olivier, additional, Bosacki, Claire, additional, Jacquin, Jean-Philippe, additional, de Laroche, Guy, additional, Fournel, Pierre, additional, Chargari, Cyrus, additional, and Magné, Nicolas, additional

Published
2016
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40. Thirty years of phase I radiochemotherapy trials: Latest development

Author

Rivoirard, Romain, primary, Vallard, Alexis, additional, Langrand-Escure, Julien, additional, Ben Mrad, Majed, additional, Wang, Guoping, additional, Guy, Jean-Baptiste, additional, Diao, Peng, additional, Dubanchet, Alexandre, additional, Deutsch, Eric, additional, Rancoule, Chloe, additional, and Magne, Nicolas, additional

Published
2016
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41. Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry

Author

Vallard, Alexis, primary, Guy, Jean-Baptiste, additional, Mengue Ndong, Sylvie, additional, Vial, Nicolas, additional, Rivoirard, Romain, additional, Auberdiac, Pierre, additional, Méry, Benoîte, additional, Langrand-Escure, Julien, additional, Espenel, Sophie, additional, Moncharmont, Coralie, additional, Ben Mrad, Majed, additional, Diao, Peng, additional, Goyet, Dominique, additional, and Magné, Nicolas, additional

Published
2016
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42. Real-World Outcomes of Combination Chemotherapy with Trabectedin plus Pegylated Liposomal Doxorubicin in Patients with Recurrent Ovarian Cancer: A Single-Center Experience

Author

Moriceau, Guillaume, primary, Rivoirard, Romain, additional, Méry, Benoîte, additional, Vallard, Alexis, additional, Pacaut, Cécile, additional, Trone, Jane-Chloé, additional, Espenel, Sophie, additional, Bosacki, Claire, additional, Jacquin, Jean-Philippe, additional, and Magné, Nicolas, additional

Published
2016
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43. Clinical Impact of Bevacizumab in Patients with Relapsed Glioblastoma: Focus on a Real-Life Monocentric SurVey (SV1 Study)

Author

Rivoirard, Romain, primary, Chargari, Cyrus, additional, Guy, Jean-Baptiste, additional, Nuti, Christophe, additional, Peoc''h, Michel, additional, Forest, Fabien, additional, Falk, Alexander Tuan, additional, Garin, Clemence, additional, Adjabi, Anissa, additional, Hoarau, Delphine, additional, Fotso, Marie-Jeannette, additional, Langrand Escure, Julien, additional, Moriceau, Guillaume, additional, Fournel, Pierre, additional, Boutet, Claire, additional, and Magné, Nicolas, additional

Published
2016
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44. Cancer patients treated with intravenous chemotherapy for the first time. What are their needs? What do they lack? A qualitative–quantitative mixed approach.

Author

Garcia, Max-Adrien, Kalecinski, Julie, Oriol, Mathieu, Bonne, Armand, Lofti, Mohamed, Espenel, Sophie, Tinquaut, Fabien, Fournel, Pierre, Collard, Olivier, Vassal, Cécile, Rivoirard, Romain, Regnier, Véronique, Chauvin, Franck, and Bourmaud, Aurélie

Subjects
CANCER treatment, CANCER chemotherapy, CANCER patient psychology, LIFESTYLES & health, PATIENT education
Abstract

The article discusses initial treatment of cancer with intravenous chemotherapy. Topics discussed include impact of the treatment on patients' psychological and physical states and lifestyles, evaluation of the treatment through food analysis by patients, and importance of patient education program for the patients.

Published
2018
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45. A retrospective survey of the last 3 months of life in patients carrying glioblastoma: Clinical treatments and profiles.

Author

Rivoirard, Romain, Vallard, Alexis, Boutet, Claire, Falk, Alexander Tuan, Garin, Clemence, Adjabi, Anissa, Hoarau, Delphine, Forest, Fabien, Fotso, Marie-Jeannette, Rancoule, Chloe, and Magné, Nicolas

Subjects
*TREATMENT of brain cancer, *GLIOBLASTOMA multiforme treatment, *PALLIATIVE treatment
Abstract

Glioblastoma is one of the most common types of primary brain tumor. In situations of local recurrence, physicians can suggest either specific palliative anticancer treatments (SPAT; surgery, chemotherapy, radiotherapy) or best supportive care (BSC). The objective of the present study was to identify clinical factors that may have influenced the continuation or cessation of SPAT during the final 3 months of life in patients with glioblastoma. In the present retrospective single-center study, all records of patients treated for glioblastoma, who succumbed to the disease between June 2006 and February 2014, were assessed. All selected patients were divided into two groups, according to treatments received during the last 3 months of life: The SPAT and BSC groups. A total of 148 patients were included: 81 patients in the SPAT group (group A) and 67 patients in the BSC group (group B). A performance status equal to 0 was observed for 17.3% of patients in group A vs. 6% in group B. Following progression, chemotherapy was administered in 39.5% of cases in group A vs. 20.9% of cases in group B (P=0.0149). The mean number of lines of chemotherapy administered in group A was equal to 1.44±0.77 as compared with 1.06±0.67 in group B (P=0.0017). SPAT are utilized frequently among patients approaching mortality due to a glioblastoma. Certain factors, including the utilization of novel chemotherapy after the first progression or number of lines of chemotherapy previously administered, may have influenced physicians' decisions whether to continue with the SPAT or not. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Chemotherapy Regimen in Nonagenarian Cancer Patients: A Bi-Institutional Experience

Author

Rivoirard, Romain, primary, Chargari, Cyrus, additional, Kullab, Sharif, additional, Trone, Jane-Chloé, additional, Langrand-Escure, Julien, additional, Moriceau, Guillaume, additional, Guy, Jean-Baptiste, additional, Annede, Pierre, additional, Méry, Benoîte, additional, Moncharmont, Coralie, additional, Falk, Alexander Tuan, additional, Vedrine, Lionel, additional, Merrouche, Yacine, additional, Fournel, Pierre, additional, and Magné, Nicolas, additional

Published
2015
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47. What makes real world outcomes in soft tissue sarcomas? A mono-institutional trabectedin experience

Author

Moriceau, Guillaume, primary, Vallard, Alexis, additional, Méry, Benoîte, additional, Rivoirard, Romain, additional, Langrand-Escure, Julien, additional, Espenel, Sophie, additional, Ben Mrad, Majed, additional, Wang, Guoping, additional, Diao, Peng, additional, Fournel, Pierre, additional, Collard, Olivier, additional, and Magné, Nicolas, additional

Published
2015
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48. Uterine and Ovary Carcinosarcomas

Author

Pacaut, Cécile, primary, Bourmaud, Aurélie, additional, Rivoirard, Romain, additional, Moriceau, Guillaume, additional, Guy, Jean-Baptiste, additional, Collard, Olivier, additional, Bosacki, Claire, additional, Jacquin, Jean-Philippe, additional, Levy, Antonin, additional, Chauleur, Céline, additional, Magné, Nicolas, additional, and Merrouche, Yacine, additional

Published
2015
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49. Personnes âgées et radiothérapie : une synthèse de la littérature

Author

Vallard, Alexis, primary, Guy, Jean-Baptiste, additional, Espenel, Sophie, additional, Langrand-Escure, Julien, additional, Trone, Jane-Chloé, additional, Méry, Benoîte, additional, Moriceau, Guillaume, additional, Rivoirard, Romain, additional, de Laroche, Guy, additional, Chargari, Cyrus, additional, and Magné, Nicolas, additional

Published
2015
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50. Cancers rares et nouvelles techniques de radiothérapie

Author

Espenel, Sophie, primary, Trone, Jane-Chloé, additional, Vallard, Alexis, additional, Guy, Jean-Baptiste, additional, Moriceau, Guillaume, additional, Méry, Benoîte, additional, Langrand-Escure, Julien, additional, Rivoirard, Romain, additional, de Laroche, Guy, additional, Chargari, Cyrus, additional, and Magné, Nicolas, additional

Published
2015
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