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2. Outcomes of octogenarians and nonagenarians with Pseudomonas aeruginosa bacteremia: a multicenter retrospective study

Author

Atamna, Alaa, Margalit, Ili, Ayada, Gida, Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Ruben, Rivera, Alba, Pulcini, Celine, Fattah, Manal Abdel, Haquin, Justine, Macgowan, Alasdair, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, de Cueto, Marina, Oliver, Antonio, de Gopegui, Enrique Ruiz, Cano, Angela, Machuca, Isabel, Gozalo-Marguello, Monica, Martinez-Martinez, Luis, Gonzalez-Barbera, Eva M., Alfaro, Iris Gomez, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller–Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstei, Yaakov, and Yahav, Dafna

Published
2023
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3. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis

Author

Galán-Sánchez, Fátima, Gracia-Ahufinger, Irene, Martínez-Martínez, Luis, Liébana-Martos, Carmen, Roldán, Carolina, Sánchez-Calvo, Juan Manuel, Clavijo, Encarnación, Mora-Navas, Laura, Aznar, Javier, Lepe, José Antonio, Rodríguez-Villodres, Ángel, Recacha, Esther, Casas-Círia, Francisco Javier, Martínez-Rubio, Carmen, Sempere-Alcocer, Marco Antonio, Martín-Hita, Lina, Seral, Cristina, López-Calleja, Ana Isabel, Aspiroz, Carmen, Monforte, Marisa, Iglesia-Martínez, Pedro de la, Jimenez-Guerra, Gemma, Riera-Pérez, Elena, Collado, Carmen, Gallegos, Carmen, Mulet, Xavier, Fernández-Muñoz, Almudena, Sastre-Femenía, Miquel Àngel, Gomis-Font, María Antonia, Zamorano, Laura, Oliver, Antonio, Siller-Ruiz, María, Calvo, Jorge, Quesada, Dolores, Wang, Jun Hao, Pitart, Cristina, Marco, Francesc, Prim, Nuria, Horcajada, Juan Pablo, Padilla, Eduardo, Del Barrio-Tofiño, Ester, Viñado-Pérez, Belen, Larrosa, Nieves, Tubau, Fe, Capilla, Silvia, Casabella, Antonio, Pérez-Moreno, Mar Olga, Padilla, Emma, Ballestero, Mónica, Rivera, Alba, Navarro, Ferrán, Gómez-Bertomeu, Fréderic, Pardo-Granell, Sergio, Picó-Plana, Ester, Guerrero, Dolores, Sarvisé-Buil, Carolina, Belles-Belles, Alba, Fernández-Esgueva, Marta, Ortega-Lafont, María del Pilar, García, Inmaculada, Arenal-Andrés, Noelia, Hernando-Real, Susana, Ibáñez, Rosario, Martínez, Jesús, Becerra, Federico, Aldea-Mansilla, Carmen, Alaoui-Sosse, Asmaa, González, José Carlos, Guzman-Puche, Julia, Blázquez-Andrada, Miguel Ángel, Martínez-Ramírez, Nora Mariela, Beteta, Alicia, Gomila-Sard, Bárbara, Almaraz, Salvador Giner, Garduño, Eugenio, Juiz-González, Pedro Miguel, Arca-Suárez, Jorge, Alba, Javier, Alonso, Pilar, Rodríguez, Ana Isabel, Paz-Vidal, María Isabel, García-Campello, Marta, Camacho, Pablo, Pallarés, María de los Ángeles, Pérez del Molino, María Luisa, Coira, Amparo, Barbeito, Gema, Rincón, Anniris, Vasallo-Vidal, Francisco José, Alonso-Acero, Laura, Iglesias-Llorente, Laura, Bordes-Benites, Ana, Florén-Zabala, Laura, Azcona, José Manuel, Alonso, Carla Andrea, Sáenz, Yolanda, Lamata-Subero, Marta, Molina, David, González-Torralba, Ana, Villa, Jennifer, Viedma, Esther, Cercenado, Emilia, Alarcón, Teresa, Vargas, Paula, Díez, María, Cantón, Rafael, Ruiz, Patricia, Sánchez-Romero, María Isabel, Pérez-García, Felipe, Yagüe-Guirao, Genoveva, Oteiza, Amaia Concepción, Leiva, José, Portillo, María Eugenia, Canut-Blasco, Andrés, Vidal, Matxalen, Alonso, Iker, Zuriarrain, Maider, Barrios-Andrés, José Luis, Sastre-Femenia, Miquel Àngel, Taltavull, Biel, López-Causapé, Carla, and Oteo-Iglesias, Jesús

Published
2023
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5. Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study

Author

Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Ruben, Rivera, Alba, Pulcini, Celine, Fattah, Manal Abdel, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, de Cueto, Marina, Oliver, Antonio, de Gopegui, Enrique Ruiz, Cano, Angela, Machuca, Isabel, Gozalo-Marguello, Monica, Martinez-Martinez, Luis, Gonzalez-Barbera, Eva M., Alfaro, Iris Gomez, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller–Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, and Yahav, Dafna

Published
2022
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6. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Martínez-Martínez, Luis, Bou, Germán, Zamorano, Laura, Sánchez-Diener, Irina, Galán, Fátima, Gracia, Irene, Rodríguez, Manuel Antonio, Martín, Lina, Sánchez, Juan Manuel, Viñuela, Laura, García, M<ce:sup loc='post">a</ce:sup> Victoria, Lepe, José Antonio, Aznar, Javier, López-Hernández, Inma, Seral, Cristina, Castillo-García, Francisco Javier, López-Calleja, Ana Isabel, Aspiroz, Carmen, Iglesia, Pedro de la, Ramón, Susana, Riera, Elena, Pérez, María Cruz, Gallegos, Carmen, Calvo, Jorge, Quesada, María Dolores, Pitart, Cristina, Marco, Francesc, Hoyos, Yannick, Horcajada, Juan Pablo, Larrosa, Nieves, González, Juan José, Tubau, Fe, Capilla, Silvia, Pérez-Moreno, Mar Olga, Centelles, M<ce:sup loc='post">a</ce:sup> José, Padilla, Emma, Rivera, Alba, Mirelis, Beatriz, Rodríguez-Tarazona, Raquel Elisa, Arenal-Andrés, Noelia, Ortega, María del Pilar, Megías, Gregoria, García, Inmaculada, Colmenarejo, Cristina, González, José Carlos, Martínez, Nora Mariela, Gomila, Bárbara, Giner, Salvador, Tormo, Nuria, Garduño, Eugenio, Agulla, José Andrés, Seoane, Alejandro, Pita, Julia, Vidal, Isabel Paz, Guzmán, David Mauricio, García, Marta, Pérez del Molino, María Luisa, Barbeito, Gema, Artiles, Fernando, Azcona-Gutiérrez, José Manuel, Sáenz, Yolanda, Oteo, José Antonio, González, Ana, Villa, Jennifer, Chaves, Fernando, Cercenado, Emilia, Alarcón, Teresa, Zurita, Nelly Daniela, Gijón, Desiré, Merino, Irene, Morosini, María Isabel, Cantón, Rafael, Sánchez, María Isabel, Moreno, Laura, Yagüe, Genoveva, Leiva, José, Barrios, José Luis, Canut, Andrés, Oteo, Jesús, Cortes-Lara, Sara, Barrio-Tofiño, Ester del, López-Causapé, Carla, and Oliver, Antonio

Published
2021
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7. Risk factors for mortality among patients with Pseudomonas aeruginosa bacteraemia: a retrospective multicentre study

Author

Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Ruben, Rivera, Alba, Pulcini, Celine, Fattah, Manal Abdel, Haquin, Justine, MacGowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Maurer, Susanna, Rodriguez-Bano, Jesus, Morales, Isabel, Oliver, Antonio, de Gopegui, Enrique Ruiz, Cano, Angela, Machuca, Isabel, Gozalo-Marguello, Monica, Martinez-Martinez, Luis, Gonzalez-Barbera, Eva M., Alfaro, Iris Gomez, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, and Yahav, Dafna

Published
2020
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8. Estrategias biotecnológicas para la reducción del grado alcohólico : empleo de Schizosaccharomyces spp. en la elaboración de vino Verdejo

Author

Aguilar Rivera, Alba, Ruipérez Prádanos, Violeta, Universidad de Valladolid. Escuela Técnica Superior de Ingenierías Agrarias, Aguilar Rivera, Alba, Ruipérez Prádanos, Violeta, and Universidad de Valladolid. Escuela Técnica Superior de Ingenierías Agrarias

Abstract

Debido al cambio climático, en los últimos años se han observado cambios en la composición de la uva y un incremento en el contenido en azúcares y del pH, produciéndose vinos con mayor graduación alcohólica y con menor acidez. Una estrategia biotecnológica prometedora para la reducción del contenido inicial de glucosa en los mostos es el empleo de las enzimas glucosa oxidasa (GOX) y catalasa (CAT). Su uso permite disminuir el grado alcohólico final, sin embargo, durante este tratamiento se ha observado un incremento notable en el contenido de ácido glucónico. Por ello, la capacidad que poseen algunas cepas de la levadura Schizosaccharomyces pombe para reducir la concentración de ácido glucónico es de gran interés enológico. En el presente trabajo, se evalúa el uso de diferentes cepas de Schizosaccharomyces spp. en la fermentación de un mosto Verdejo tratado enzimáticamente con GOX/CAT. Los resultados obtenidos sugieren que el uso de un tratamiento enzimático junto con el empleo de Schizosaccharomyces spp. puede ser eficaz para la reducción del contenido alcohólico final de los vinos., Grado en Enología

Published
2024

10. A multilevel multimodal circuit enhances action selection in Drosophila.

Author

Ohyama, Tomoko, Schneider-Mizell, Casey M, Fetter, Richard D, Aleman, Javier Valdes, Franconville, Romain, Rivera-Alba, Marta, Mensh, Brett D, Branson, Kristin M, Simpson, Julie H, Truman, James W, Cardona, Albert, and Zlatic, Marta

Subjects
Central Nervous System, Neural Pathways, Interneurons, Motor Neurons, Synapses, Animals, Drosophila melanogaster, Cues, Signal Transduction, Larva, Locomotion, Female, Sensory Receptor Cells, MD Multidisciplinary, General Science & Technology
Abstract

Natural events present multiple types of sensory cues, each detected by a specialized sensory modality. Combining information from several modalities is essential for the selection of appropriate actions. Key to understanding multimodal computations is determining the structural patterns of multimodal convergence and how these patterns contribute to behaviour. Modalities could converge early, late or at multiple levels in the sensory processing hierarchy. Here we show that combining mechanosensory and nociceptive cues synergistically enhances the selection of the fastest mode of escape locomotion in Drosophila larvae. In an electron microscopy volume that spans the entire insect nervous system, we reconstructed the multisensory circuit supporting the synergy, spanning multiple levels of the sensory processing hierarchy. The wiring diagram revealed a complex multilevel multimodal convergence architecture. Using behavioural and physiological studies, we identified functionally connected circuit nodes that trigger the fastest locomotor mode, and others that facilitate it, and we provide evidence that multiple levels of multimodal integration contribute to escape mode selection. We propose that the multilevel multimodal convergence architecture may be a general feature of multisensory circuits enabling complex input-output functions and selective tuning to ecologically relevant combinations of cues.

Published
2015

14. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis

Author

Sastre-Femenia, Miquel Àngel, primary, Fernández-Muñoz, Almudena, additional, Gomis-Font, María Antonia, additional, Taltavull, Biel, additional, López-Causapé, Carla, additional, Arca-Suárez, Jorge, additional, Martínez-Martínez, Luis, additional, Cantón, Rafael, additional, Larrosa, Nieves, additional, Oteo-Iglesias, Jesús, additional, Zamorano, Laura, additional, Oliver, Antonio, additional, Galán-Sánchez, Fátima, additional, Gracia-Ahufinger, Irene, additional, Liébana-Martos, Carmen, additional, Roldán, Carolina, additional, Sánchez-Calvo, Juan Manuel, additional, Clavijo, Encarnación, additional, Mora-Navas, Laura, additional, Aznar, Javier, additional, Lepe, José Antonio, additional, Rodríguez-Villodres, Ángel, additional, Recacha, Esther, additional, Casas-Círia, Francisco Javier, additional, Martínez-Rubio, Carmen, additional, Sempere-Alcocer, Marco Antonio, additional, Martín-Hita, Lina, additional, Seral, Cristina, additional, López-Calleja, Ana Isabel, additional, Aspiroz, Carmen, additional, Monforte, Marisa, additional, Iglesia-Martínez, Pedro de la, additional, Jimenez-Guerra, Gemma, additional, Riera-Pérez, Elena, additional, Collado, Carmen, additional, Gallegos, Carmen, additional, Mulet, Xavier, additional, Sastre-Femenía, Miquel Àngel, additional, Siller-Ruiz, María, additional, Calvo, Jorge, additional, Quesada, Dolores, additional, Wang, Jun Hao, additional, Pitart, Cristina, additional, Marco, Francesc, additional, Prim, Nuria, additional, Horcajada, Juan Pablo, additional, Padilla, Eduardo, additional, Del Barrio-Tofiño, Ester, additional, Viñado-Pérez, Belen, additional, Tubau, Fe, additional, Capilla, Silvia, additional, Casabella, Antonio, additional, Pérez-Moreno, Mar Olga, additional, Padilla, Emma, additional, Ballestero, Mónica, additional, Rivera, Alba, additional, Navarro, Ferrán, additional, Gómez-Bertomeu, Fréderic, additional, Pardo-Granell, Sergio, additional, Picó-Plana, Ester, additional, Guerrero, Dolores, additional, Sarvisé-Buil, Carolina, additional, Belles-Belles, Alba, additional, Fernández-Esgueva, Marta, additional, Ortega-Lafont, María del Pilar, additional, García, Inmaculada, additional, Arenal-Andrés, Noelia, additional, Hernando-Real, Susana, additional, Ibáñez, Rosario, additional, Martínez, Jesús, additional, Becerra, Federico, additional, Aldea-Mansilla, Carmen, additional, Alaoui-Sosse, Asmaa, additional, González, José Carlos, additional, Guzman-Puche, Julia, additional, Blázquez-Andrada, Miguel Ángel, additional, Martínez-Ramírez, Nora Mariela, additional, Beteta, Alicia, additional, Gomila-Sard, Bárbara, additional, Almaraz, Salvador Giner, additional, Garduño, Eugenio, additional, Juiz-González, Pedro Miguel, additional, Alba, Javier, additional, Alonso, Pilar, additional, Rodríguez, Ana Isabel, additional, Paz-Vidal, María Isabel, additional, García-Campello, Marta, additional, Camacho, Pablo, additional, Pallarés, María de los Ángeles, additional, Pérez del Molino, María Luisa, additional, Coira, Amparo, additional, Barbeito, Gema, additional, Rincón, Anniris, additional, Vasallo-Vidal, Francisco José, additional, Alonso-Acero, Laura, additional, Iglesias-Llorente, Laura, additional, Bordes-Benites, Ana, additional, Florén-Zabala, Laura, additional, Azcona, José Manuel, additional, Alonso, Carla Andrea, additional, Sáenz, Yolanda, additional, Lamata-Subero, Marta, additional, Molina, David, additional, González-Torralba, Ana, additional, Villa, Jennifer, additional, Viedma, Esther, additional, Cercenado, Emilia, additional, Alarcón, Teresa, additional, Vargas, Paula, additional, Díez, María, additional, Ruiz, Patricia, additional, Sánchez-Romero, María Isabel, additional, Pérez-García, Felipe, additional, Yagüe-Guirao, Genoveva, additional, Oteiza, Amaia Concepción, additional, Leiva, José, additional, Portillo, María Eugenia, additional, Canut-Blasco, Andrés, additional, Vidal, Matxalen, additional, Alonso, Iker, additional, Zuriarrain, Maider, additional, and Barrios-Andrés, José Luis, additional

Published
2023
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19. Significant increase of CTX-M-15-ST131 and emergence of CTX-M-27-ST131 Escherichia coli high-risk clones causing healthcare-associated bacteraemia of urinary origin in Spain (ITUBRAS-2 project)

Author

Becerra-Aparicio, Federico, primary, Gómez-Zorrilla, Silvia, additional, Hernández-García, Marta, additional, Gijón, Desiré, additional, Siverio, Ana, additional, Berbel, Dàmaris, additional, Sánchez-Carrillo, Carlos, additional, Cercenado, Emilia, additional, Rivera, Alba, additional, de Malet, Ana, additional, Xercavins, Mariona, additional, Ruiz de Gopegui, Enrique, additional, Canoura-Fernández, Luis, additional, Martínez, José Antonio, additional, Seral, Cristina, additional, Del Pozo, José Luis, additional, Cotarelo, Manuel, additional, Díaz-Regañón, Jazmín, additional, Cantón, Rafael, additional, Oliver, Antonio, additional, Horcajada, Juan Pablo, additional, and Ruiz-Garbajosa, Patricia, additional

Published
2023
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21. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.

Author

Cañada-García, Javier E., Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María E., Gijón, Desirèe, González, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, and Palacios-Baena, Zaira R.

Subjects
KLEBSIELLA pneumoniae, MOLECULAR cloning, ESCHERICHIA coli, MICROBIAL sensitivity tests, SINGLE nucleotide polymorphisms, NUCLEOTIDE sequencing
Abstract

Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain. Methods: In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis. Results: In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA−48 (263/377), blaKPC−3 (62/377), blaVIM−1 (28/377), and blaNDM−1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5). Conclusion: This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3. [ABSTRACT FROM AUTHOR]

Published
2023
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25. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

Author

Cañada García, Javier E., Moure, Zaira, Sola Campoy, Pedro J., Delgado Valverde, Mercedes, Cano, María E., Gijón, Desirèe, González, Mónica, Gracia Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, Palacios Baena, Zaira R., Pascual, Alvaro, Ruiz Carrascoso, Guillermo, Vila Estapé, Jordi, Aracil, Belén, Pérez-Vázquez, María, Oteo Iglesias, Jesús, GEMARA/GEIRAS-SEIMC/REIPI CARB-ES-19 Study Group, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Commission, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad de Sevilla. Departamento de Microbiología, Universidad de Sevilla. CTS210: Resistencia a antimicrobianos., Ministerio de Economía y Competitividad (MINECO). España, Universidad de Cantabria, Institut Català de la Salut, [Cañada-García JE, Moure Z, Sola-Campoy PJ] Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. [Delgado-Valverde M] Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Instituto de Biomedicina de Sevilla (Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla), Seville, Spain. CIBER de Enfermedades Infecciosas (CIBERINFEC), REIPI, Instituto de Salud Carlos III, Madrid, Spain. [Cano ME] Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. [Gijón D] CIBER de Enfermedades Infecciosas (CIBERINFEC), REIPI, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [Larrosa N, González-López JJ] CIBER de Enfermedades Infecciosas (CIBERINFEC), REIPI, Instituto de Salud Carlos III, Madrid, Spain. Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Plan Nacional de I+D+i (España), Ministerio de Economía y Competitividad (España), Red de Investigación Cooperativa en Investigación en Patología Infecciosa (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), and Unión Europea

Subjects
Microbiology (medical), Enzimologia, Human genome, Bacteria::bacterias gramnegativas::bacilos gramnegativos anaerobios facultativos::Enterobacteriaceae::Escherichia::Escherichia coli [ORGANISMOS], acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antibacterianos [COMPUESTOS QUÍMICOS Y DROGAS], Otros calificadores::Otros calificadores::Otros calificadores::/enzimología [Otros calificadores], Carbapenemases, Genoma humà, Microbiology, Enterobacteriàcies, Klebsiella pneumoniae, Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli [ORGANISMS], Escheríchia coli, Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniae [ORGANISMS], Enterobacteriaceae, Whole genome sequencing, Bacteria::bacterias gramnegativas::bacilos gramnegativos anaerobios facultativos::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniae [ORGANISMOS], Escherichia coli, Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [CHEMICALS AND DRUGS], Antibiòtics betalactàmics, Medicaments antibacterians, CARB-ES-19 study, Other subheadings::Other subheadings::Other subheadings::/enzymology [Other subheadings], High-risk clones, Beta lactam antibiotics
Abstract

CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain., This research was supported by grants from the Instituto de Salud Carlos III (numbers PI18CIII/00030 and PI21CIII/00039). It was also supported by Plan Nacional de I + D + i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases (grants RD16CIII/0004/0002, RD16/0016/0001, RD16/0016/0003, RD16/0016/0004, RD16/0016/0006, RD16/0016/0007, RD16/0016/0008, RD16/0016/0010, and RD16/0016/0011). Cofinanced by the European Development Regional Fund “A way to achieve Europe,” Operative Program Intelligent Growth 2014–2020. CIBER – Consorcio Centro de Investigación Biomédica en Red (CB21/13/00095, CB21/13/00012, CB21/13/00049, CB21/13/00054, CB21/13/00055, CB21/13/00068, CB21/13/00081, CB21/13/00084, and CB21/13/00099) (CIBERINFEC) and Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU also supported this work.

Published
2022

27. Recommendations of the Spanish Antibiogram Committee (COESANT) for in vitro susceptibility testing of antimicrobial agents by disk diffusion

Author

Rivera, Alba, primary, Viñado, Belén, additional, Benito, Natividad, additional, Docobo-Pérez, Fernando, additional, Fernández-Cuenca, Felipe, additional, Fernández-Domínguez, Javier, additional, Guinea, Jesús, additional, López-Navas, Antonio, additional, Moreno, Miguel Ángel, additional, Larrosa, María Nieves, additional, Oliver, Antonio, additional, and Navarro, Ferran, additional

Published
2022
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29. Table_4_CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.pdf

Author

Cañada-García, Javier E, Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María Eugenia, Gijón, Desirèe, González-Bardanca, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferrán, Oliver, Antonio, Palacios-Baena, Zaira Raquel, Pascual, Álvaro, Ruiz Carrascoso, Guillermo, Vila, Jordi, Aracil, Belén, Pérez-Vázquez, María, Oteo-Iglesias, Jesús, Cañada-García, Javier E, Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María Eugenia, Gijón, Desirèe, González-Bardanca, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferrán, Oliver, Antonio, Palacios-Baena, Zaira Raquel, Pascual, Álvaro, Ruiz Carrascoso, Guillermo, Vila, Jordi, Aracil, Belén, Pérez-Vázquez, María, and Oteo-Iglesias, Jesús

Abstract

[Objectives] CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain., [Methods] In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis., [Results] In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5)., [Conclusion] This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3.

Published
2022

30. Image_1_CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.pdf

Author

Cañada-García, Javier E, Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María Eugenia, Gijón, Desirèe, González-Bardanca, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferrán, Oliver, Antonio, Palacios-Baena, Zaira Raquel, Pascual, Álvaro, Ruiz Carrascoso, Guillermo, Vila, Jordi, Aracil, Belén, Pérez-Vázquez, María, Oteo-Iglesias, Jesús, Cañada-García, Javier E, Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María Eugenia, Gijón, Desirèe, González-Bardanca, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferrán, Oliver, Antonio, Palacios-Baena, Zaira Raquel, Pascual, Álvaro, Ruiz Carrascoso, Guillermo, Vila, Jordi, Aracil, Belén, Pérez-Vázquez, María, and Oteo-Iglesias, Jesús

Abstract

[Objectives] CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain., [Methods] In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis., [Results] In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5)., [Conclusion] This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3.

Published
2022

31. Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study

Author

Yahav, Dafna [0000-0003-3181-9791], Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Rubén, Rivera, Alba, Pulcini, Céline, Fattah, Manal Abdel, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, Cueto, Marina de, Oliver, Antonio, Ruiz de Gopegui Bordes, Enrique, Cano, Ángela, Machuca, Isabel, Gozalo-Margüello, Mónica, Martínez-Martínez, Luis, González-Barbera, Eva M., Gómez Alfaro, Iris, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, Yahav, Dafna, Yahav, Dafna [0000-0003-3181-9791], Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Rubén, Rivera, Alba, Pulcini, Céline, Fattah, Manal Abdel, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, Cueto, Marina de, Oliver, Antonio, Ruiz de Gopegui Bordes, Enrique, Cano, Ángela, Machuca, Isabel, Gozalo-Margüello, Mónica, Martínez-Martínez, Luis, González-Barbera, Eva M., Gómez Alfaro, Iris, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, and Yahav, Dafna

Abstract

[Introduction] There is no consensus regarding optimal duration of antibiotic therapy for Pseudomonas aeruginosa bacteremia. We aimed to evaluate the impact of short antibiotic course., [Methods] We present a retrospective multicenter study including patients with P. aeruginosa bacteremia during 2009–2015. We evaluated outcomes of patients treated with short (6–10 days) versus long (11–15 days) antibiotic courses. The primary outcome was a composite of 30-day mortality or bacteremia recurrence and/or persistence. Univariate and inverse probability treatment-weighted (IPTW) adjusted multivariate analysis for the primary outcome was performed. To avoid immortal time bias, the landmark method was used., [Results] We included 657 patients; 273 received a short antibiotic course and 384 a long course. There was no significant difference in baseline characteristics of patients. The composite primary outcome occurred in 61/384 patients in the long-treatment group (16%) versus 32/273 in the short-treatment group (12%) (p = 0.131). Mortality accounted for 41/384 (11%) versus 25/273 (9%) of cases, respectively. Length of hospital stay was significantly shorter in the short group [median 13 days, interquartile range (IQR) 9–21 days, versus median 15 days, IQR 11–26 days, p = 0.002]. Ten patients in the long group discontinued antibiotic therapy owing to adverse events, compared with none in the short group. On univariate and multivariate analyses, duration of therapy was not associated with the primary outcome., [Conclusions] In this retrospective study, 6–10 days of antibiotic course for P. aeruginosa bacteremia were as effective as longer courses in terms of survival and recurrence. Shorter therapy was associated with reduced length of stay and less drug discontinuation.

Published
2022

32. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

Author

Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Commission, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Cañada-García, Javier E, Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María Eugenia, Gijón, Desirèe, González-Bardanca, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferrán, Oliver, Antonio, Palacios-Baena, Zaira Raquel, Pascual, Álvaro, Ruiz Carrascoso, Guillermo, Vila, Jordi, Aracil, Belén, Pérez-Vázquez, María, Oteo-Iglesias, Jesús, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Commission, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Cañada-García, Javier E, Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María Eugenia, Gijón, Desirèe, González-Bardanca, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo-Montes, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferrán, Oliver, Antonio, Palacios-Baena, Zaira Raquel, Pascual, Álvaro, Ruiz Carrascoso, Guillermo, Vila, Jordi, Aracil, Belén, Pérez-Vázquez, María, and Oteo-Iglesias, Jesús

Abstract

CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.

Published
2022

33. Perceived Altruism as a Function of Consistency and Distinctiveness.

Author

Rivera, Alba N. and Gaes, Gerald G.

Abstract

An analysis of perceived altruism was conducted within the framework of Kelley's (1973) attributional model. In a 2 by 2 factorial design, the consistency and distinctiveness of a donor's prosocial history were manipulated. Subjects were provided with written scenarios depicting the work of a voluntary welfare organization aiding the elderly. Subsequent evaluations of the donor-actors on the altruism dimension revealed that there is a direct relationship of consistency and an inverse relationship of distinctiveness with the attribution of altruism. (Author)

Published
1973

34. Impact of the COVID-19 pandemic on the diagnosis, management and prognosis of infective endocarditis

Author

de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Luque-Márquez, Rafael, Baz, Blanca Anaya, López-Cortés, Luis Eduardo, Baena, Zaira Palacios, García López, María Victoria, Burgos, Guillermo Ojeda, Ciézar, Antonio Pláta, Reguera Iglesias, José María, Delgado, Ricardo Vivancos, Hidalgo-Tenorio, Carmen, Sequera, Sergio, Ch, Fariñas, María Carmen, González-Rico, Claudia, Gutiérrez-Díez, José Francisco, Cabezón, Gonzalo, López, Javier, San Román, Alberto, Almirante, Benito, Escolà-Vergé, Laura, Fernández, Rubén, Fernández-Hidalgo, Nuria, Gonzàlez-Alujas, Maria Teresa, Maisterra, Olga, Oristrell, Gerard, Pizzi, María Nazarena, Rello, Pau, Ríos, Remedios, Roque, Albert, Sambola, Antonia, Soriano, Toni, Cuervo, Guillermo, Grau, Immaculada, Grillo, Sara, Pruñonosa, Lourdes Mateu, Pedro-Botet Montoya, Maria Lluïsa, Camazón, Nuria Vallejo, Hernández-Meneses, Marta, Miro, Jose M., Quintana, Eduard, Barros, Antonio José, Gurgui, Mercè, Rivera, Alba, Castelo Corral, María Laura, Vidal, Efrén Sánchez, Sousa, Dolores, Pérez-Rodríguez, María Teresa, Sousa, Adrián, Suárez, Milagros, Ribas Fernández, Maria Àngels, Barca, Laura Varela, Bonet, Laura Vidal, García-Álvarez, Lara, Oteo, José A., Baza, Adrián Jerónimo, Olmos, Carmen, Vilacosta, Isidre, Domínguez-Pérez, Laura, López-Medrano, Francisco, Solera Rallo, Javier T., Moya Mur, José Luis, Elorza, Enrique Navas, Mayor, Andrea Kallmeyer, Pello, Ana María, Roca, Luis Nieto, García, María Aguilera, de las Cuevas Torres, Carmen, Béjar, Carmen Sáez, de Castro Campos, Daniel, Domínguez, Fernando, Ramos-Martínez, Antonio, García, Patricia Muñoz, Samperio, María Olmedo, Minero, Maricela Valerio, Vázquez, Elisa García, Torres, Alicia Hernández, Escudero, Encarnación Moral, Goenaga Sánchez, Miguel Ángel, Urkola, Xavier Kortajarena, Jaka, Karlos Reviejo, Bereciartua, Elena, Goikoetxea, Josune, Rodríguez, Regino, and Acevedo, Martín Reyes

Published
2021
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36. Usar el aprendizaje cooperativo para crear videos auténticos para el desarrollo del habilidad de hablar de los estudiantes de inglés como lengua extranjera

Author

Vindell Rivera, Alba Marina and Salazar Flores, Isayana Mariela

Subjects
371.358 Tecnología educativa, 370.11 Innovaciones educativas, 371.3 Didáctica y Pedagogía, 421.54 Pronunciación
Abstract

Esta investigación está diseñada para probar qué tan efectivos son estos videos en la clase de inglés, principalmente en el desarrollo de la habilidad de hablar realizado en pequeños grupos. Este estudio involucró a 18 estudiantes de 10th calificación. El estudio investigó si la aplicación de videoclips con grupos pequeños a lo largo con actividades individuales de enseñanza-aprendizaje mejoraron las habilidades orales de los jóvenes de inglés como lengua extranjera los alumnos más. Los resultados sugirieron que enseñar a hablar a estudiantes de EFL con videoclips usando Las técnicas y actividades para grupos reducidos podrían ser una de las mejores alternativas para mejorar representaciones orales de jóvenes estudiantes. El estudio mostró que el uso del aprendizaje cooperativo mejoró el habla de los estudiantes. habilidades. Los alumnos mostraron mejora en algunos aspectos como la pronunciación, dominio del vocabulario y confianza.

Published
2021

37. Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis

Author

Cortes-Lara, Sara, primary, Barrio-Tofiño, Ester del, additional, López-Causapé, Carla, additional, Oliver, Antonio, additional, Martínez-Martínez, Luis, additional, Bou, Germán, additional, Zamorano, Laura, additional, Sánchez-Diener, Irina, additional, Galán, Fátima, additional, Gracia, Irene, additional, Rodríguez, Manuel Antonio, additional, Martín, Lina, additional, Sánchez, Juan Manuel, additional, Viñuela, Laura, additional, García, Ma Victoria, additional, Lepe, José Antonio, additional, Aznar, Javier, additional, López-Hernández, Inma, additional, Seral, Cristina, additional, Castillo-García, Francisco Javier, additional, López-Calleja, Ana Isabel, additional, Aspiroz, Carmen, additional, Iglesia, Pedro de la, additional, Ramón, Susana, additional, Riera, Elena, additional, Pérez, María Cruz, additional, Gallegos, Carmen, additional, Calvo, Jorge, additional, Quesada, María Dolores, additional, Pitart, Cristina, additional, Marco, Francesc, additional, Hoyos, Yannick, additional, Horcajada, Juan Pablo, additional, Larrosa, Nieves, additional, González, Juan José, additional, Tubau, Fe, additional, Capilla, Silvia, additional, Pérez-Moreno, Mar Olga, additional, Centelles, Ma José, additional, Padilla, Emma, additional, Rivera, Alba, additional, Mirelis, Beatriz, additional, Rodríguez-Tarazona, Raquel Elisa, additional, Arenal-Andrés, Noelia, additional, Ortega, María del Pilar, additional, Megías, Gregoria, additional, García, Inmaculada, additional, Colmenarejo, Cristina, additional, González, José Carlos, additional, Martínez, Nora Mariela, additional, Gomila, Bárbara, additional, Giner, Salvador, additional, Tormo, Nuria, additional, Garduño, Eugenio, additional, Agulla, José Andrés, additional, Seoane, Alejandro, additional, Pita, Julia, additional, Vidal, Isabel Paz, additional, Guzmán, David Mauricio, additional, García, Marta, additional, Pérez del Molino, María Luisa, additional, Barbeito, Gema, additional, Artiles, Fernando, additional, Azcona-Gutiérrez, José Manuel, additional, Sáenz, Yolanda, additional, Oteo, José Antonio, additional, González, Ana, additional, Villa, Jennifer, additional, Chaves, Fernando, additional, Cercenado, Emilia, additional, Alarcón, Teresa, additional, Zurita, Nelly Daniela, additional, Gijón, Desiré, additional, Merino, Irene, additional, Morosini, María Isabel, additional, Cantón, Rafael, additional, Sánchez, María Isabel, additional, Moreno, Laura, additional, Yagüe, Genoveva, additional, Leiva, José, additional, Barrios, José Luis, additional, Canut, Andrés, additional, and Oteo, Jesús, additional

Published
2021
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39. Ressenyes

Author

Caballé Rivera, Alba

Abstract

Index de les obres ressenyades: Vivian KINNAIRD ; Derek HALL, Tourism : a gender analysis

Published
2021

40. A Large Multicenter Prospective Study of Community-Onset Healthcare Associated Bacteremic Urinary Tract Infections in the Era of Multidrug Resistance: Even Worse than Hospital Acquired Infections?

Author

Gómez-Zorrilla, Silvia, Becerra-Aparicio, Federico, López Montesinos, Inmaculada, Ruiz de Gopegui, Enrique, Grau, Inmaculada, Pintado, Vicente, Padilla, Belén, Benito, Natividad, Boix-Palop, Lucía, Fariñas, Maria Carmen, Peñaranda, María, Gamallo, Maria Rocío, Martinez, Jose Antonio, Morte-Romea, Elena, Del Pozo, Jose Luis, Durán-Jordá, Xavier, Díaz-Regañón, Jazmin, López-Mendoza, Diego, Cantón, Rafael, Oliver, Antonio, Ruiz-Garbajosa, Patricia, Horcajada, Juan Pablo, Siverio, Ana, Gijón, Desiré, Merino, Irene, López-Causapé, Carla, Sabé, Nuria, Shaw, Evelyn, Berbel, Dámaris, Tubau Quintano, Fe, Sánchez Carrillo, Carlos, Cercenado, Emilia, Sendra, Elena, Rubio, Verónica, Rivera, Alba, Calvo, Esther, Badía, Cristina, Xercavins, Mariona, de Malet, Ana, Canoura-Fernández, Luis, Salvo, Soledad, Paño-Pardo, Jose Ramón, Carmona-Torre, Francisco, and Universidad de Cantabria

Subjects
Microbiology (medical), medicine.medical_specialty, Hospital-acquired infections, business.industry, medicine.drug_class, Proportional hazards model, Urinary system, Antibiotics, Logistic regression, medicine.disease, Urinary tract infections, Multiple drug resistance, Infectious Diseases, Multidrug resistant, Bacteremia, Internal medicine, Medicine, Bloodstream infections, business, Prospective cohort study, Community-onset healthcare-associated infections, Cohort study, Original Research
Abstract

Introduction: Healthcare-associated (HCA) infections represent a growing public health problem. The aim of this study was to compare community-onset healthcare associated (CO-HCA) bacteremic urinary tract infections (BUTI) and hospital-acquired (HA)-BUTI with special focus on multidrug resistances (MDR) and outcomes. Methods: ITUBRAS-project is a prospective multicenter cohort study of patients with HCA-BUTI. All consecutive hospitalized adult patients with CO-HCA-BUTI or HA-BUTI episode were included in the study. Exclusion criteria were: patients \ 18 years old, non-hospitalized patients, bacteremia from another source or primary bacteremia, non-healthcare related infections and infections caused by unusual pathogens of the urinary tract. Th main outcome variable was 30-day all-cause mortality with day 1 as the first day of positive blood culture. Logistic regression was used to analyze factors associated with clinical cure at hospital discharge and with receiving inappropriate initial antibiotic treatment. Cox regression was used to evaluate 30-day all-cause mortality. Results: Four hundred forty-three episodes were included, 223 CO-HCA-BUTI. Patients with CO-HCA-BUTI were older (p \ 0.001) and had more underlying diseases (p = 0.029) than those with HA-BUTI. The severity of the acute illness (Pitt score) was also higher in CO-HCABUTI (p = 0.026). Overall, a very high rate of MDR profiles (271/443, 61.2%) was observed, with no statistical differences between groups. In multivariable analysis, inadequate empirical treatment was associated with MDR profile (aOR 3.35; 95% CI 1.77?6.35), Pseudomonas aeruginosa (aOR 2.86; 95% CI 1.27?6.44) and Charlson index (aOR 1.11; 95% CI 1.01?1.23). Mortality was not associated with the site of acquisition of the infection or the presence of MDR profile. However, in the logistic regression analyses patients with CO-HCA-BUTI (aOR 0.61; 95% CI 0.40?0.93) were less likely to present clinical cure. Conclusion: The rate of MDR infections was worryingly high in our study. No differences in MDR rates were found between CO-HCA-BUTI and HA-BUTI, in the probability of receiving inappropriate empirical treatment or in 30-day mortality. However, CO-HCA-BUTIs were associated with worse clinical cure. Funding. This study and the journal’s Rapid Service Fee are sponsored and funded by MSD Spain. The study was also supported by Plan Nacional de I+D+i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0004, RD16/ 0016/0005, RD16/0016/0007, RD16/0016/0010, RD16/0016/0011 and RD16/0016/0015), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (ERDF), Operative program Intelligent Growth 2014–2020.

Published
2021

41. Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement

Author

Rivera, Alba, Sánchez, Alba, Luque Pardos, Sònia, Mur, Isabel, Puig, Lluís, Crusi, Xavier, González, José Carlos, Sorli Redó, M. Luisa, González, Aránzazu, Horcajada Gallego, Juan Pablo, Navarro, Ferran, and Benito, Natividad

Subjects
musculoskeletal diseases, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Prosthetic joint infection, medicine.medical_treatment, 030106 microbiology, Cefazolin, Antibiotic levels, knee arthroplasty, surgical antimicrobial prophylaxis, Biochemistry, Microbiology, Prosthetic joint infection prevention, Article, Intraoperative cultures, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Hip replacement, Serum bactericidal titer, medicine, Surgical antimicrobial prophylaxis, surgical site infection prevention, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, prosthetic joint infection, hip arthroplasty, 030222 orthopedics, intraoperative cultures, prosthetic joint infection prevention, business.industry, lcsh:RM1-950, Surgical wound, antibiotic levels, Antimicrobial, Arthroplasty, Knee arthroplasty, Surgical site infection prevention, Infectious Diseases, lcsh:Therapeutics. Pharmacology, Vancomycin, Hip arthroplasty, Gentamicin, serum bactericidal titer, business, Cefuroxime, medicine.drug
Abstract

Surgical antimicrobial prophylaxis (SAP) is important for the prevention of prosthetic joint infections (PJIs) and must be effective against the microorganisms most likely to contaminate the surgical site. Our aim was to compare different SAP regimens (cefazolin, cefuroxime, or vancomycin, alone or combined with gentamicin) in patients undergoing total knee (TKA) and hip (THA) arthroplasty. In this preclinical exploratory analysis, we analyzed the results of intraoperative sample cultures, the ratio of plasma antibiotic levels to the minimum inhibitory concentrations (MICs) for bacteria isolated at the surgical wound and ATCC strains, and serum bactericidal titers (SBT) against the same microorganisms. A total of 132 surgical procedures (68 TKA, 64 THA) in 128 patients were included. Cultures were positive in 57 (43.2%) procedures (mostly for coagulase-negative staphylococci and Cutibacterium spp.), the rate was lower in the group of patients receiving combination SAP (adjusted OR 0.475, CI95% 0.229&ndash, 0.987). The SAP regimens evaluated achieved plasma levels above the MICs in almost all of intraoperative isolates (93/94, 98.9%) and showed bactericidal activity against all of them (SBT range 1:8&ndash, 1:1024), although SBTs were higher in patients receiving cefazolin and gentamicin-containing regimens. The potential clinical relevance of these findings in the prevention of PJIs remains to be determined.

Published
2021

43. Evaluation of the Scrum methodology of internal project in the integration of data systems for the Globant company

Author

Pinto Sepulveda, Duvan Steven, Rivera Alba, David Ernesto, Jaraba Ramirez, Peeter Mario, and Ariza Aguilera, Dora Alba

Subjects
Project management, Metodologías ágiles, Autonomía de equipo, Gestión de proyecto, Optimization of human resources, Proyectos de desarrollo, Team autonomy, Agile methodologies, Evaluación de proyectos, Optimización de recursos humanos, Asistencia técnica
Abstract

Globant, empresa Argentina de desarrollo tecnológico con más de 1,000 proyectos a nivel mundial e internos para soporta el crecimiento que tiene cada año con sus empleados de planta. El proyecto que estamos analizando es BW4, su principal objetivo es integrar las bases de datos de 3 áreas (M&A, Accounting y Planning) que tiene Globant a nivel interno con el fin de centralizar la información y obtener las métricas necesarias para el seguimiento estratégico de los proyectos de la compañía. Dentro de este proyecto, se está implementando la metodología ágil Scrum, para el mejoramiento y desarrollo, uno de los principales problemas que se encontró fue que no se tener un aprovechamiento óptimo de los recursos humanos que se poseía. La investigación de la metodología hace referencia al uso de la misma teniendo en cuenta que el proyecto se encuentra en ejecución en su séptimo mes. Para el análisis y evaluación de la metodología Scrum frente al proyecto y el impacto se obtuvieron las siguientes conclusiones: • Al principio del proyecto se obtuvo poco conocimiento de la metodología y de las tecnologías frente al proyecto, esto se ve reflejado en la velocidad (Velocity). • La planning que se realiza en cada Sprint no se termina de comprometer ya que se evidencia que durante el Sprint pueden llegar nuevos requerimientos o prioridades que no se tenían en el Sprint. • El trabajo de equipo y el acompañamiento por parte del Scrum Master es uno de los puntos más fuertes según reveló las encuestas y estudio realizado. Otro punto fuerte del equipo es la maduración que se va obteniendo durante el Sprint, las métricas de puntos alcanzados vs los puntos comprometidos muestran una curva de aprendizaje rápida en la metodología y proyecto. • Una debilidad que se evidenció en la encuesta realizada es que el PO no tiene total autonomía por el producto, ya que la organización en ocasiones no respeta la autonomía brindada al inicio del proyecto, esto puede ocasionar retrasos en la claridad del producto y por ende perdida de presupuesto. • Se evidencia una oportunidad de mejora en el detalle de las historias de usuario que el equipo debe trabajar cada Sprint, este es el punto más débil de acuerdo al análisis realizado por el equipo de trabajo. En conclusión, de acuerdo a nuestro análisis las personas que están trabajando dentro del proyecto tienen una curva de aprendizaje rápida lo que hace un rápido crecimiento frente al valor entregado, por otro lado, se debe analizar y mejorar las prácticas de la metodología para mejorar la velocidad de entrega de las historias de usuario por Sprint. Se recomienda que el PO, Scrum Master y equipo trabajen en la autonomía del producto para obtener claridad dentro del backlog y así aumentar la productividad de cada recurso. Globant, an Argentine technology development company with more than 1000 projects worldwide and internally to support the growth it has every year. The project that we are analyzing is BW4, its main objective is to integrate the databases of 3 areas (M&A, Accounting and Planning) that Globant has internally in order to centralize the information and obtain the necessary metrics for the strategic monitoring of the company's projects. Within this project, the agile Scrum methodology is implemented, one of the main problems in the analysis of the methodology is that you don’t have an optimal use of the human resources that you have. The research of the methodology refers to the use of it, taking into account that the project is in execution in its seventh month. For the analysis and evaluation of the Scrum methodology regarding the project and the impact, the following conclusions were obtained: • At the beginning of the project, little knowledge of the methodology and technologies was obtained, this is reflected in the speed (Velocity) during the first sprints. • The planning that is carried out for each Sprint is not fully compromised since it is evident that during the Sprint new requirements or priorities may arrive that were not had in the Sprint. • The teamwork and the commitment by the Scrum Master is one of the strongest points as revealed by the surveys and study carried out. • Other strong point of the team is the maturation that is being obtained during the Sprints, the metrics of points achieved vs points committed shows a rapid learning curve in the methodology and project. A weakness that was evidenced in the survey carried out is that the PO does not have total autonomy of the product, since the organization sometimes does not respect the autonomy provided at the beginning of the project, this can cause delays in the clarity of the product and therefore loss budget. • An opportunity for improvement is in the detail of the user stories that the team must work on each Sprint, this is the weakest point according to the analysis carried out by the work team. In conclusion, according to our analysis, the people that are working on the project have a rapid learning curve, which makes quick growth compared to the value delivered, on the other hand, the practices of the methodology must be analyzed and improved in order to get better speed of delivery of user stories for each Sprint. It is recommended that the PO, Scrum Master and team work on product autonomy to gain clarity within the backlog and thus increase the productivity of each resource Especialista en Gerencia de Tecnología Especialización

Published
2020

44. Combination versus monotherapy as definitive treatment for Pseudomonas aeruginosa bacteraemia: a multicentre retrospective observational cohort study

Author

Babich, Tanya, primary, Naucler, Pontus, additional, Valik, John Karlsson, additional, Giske, Christian G, additional, Benito, Natividad, additional, Cardona, Ruben, additional, Rivera, Alba, additional, Pulcini, Celine, additional, Abdel Fattah, Manal, additional, Haquin, Justine, additional, MacGowan, Alasdair, additional, Grier, Sally, additional, Gibbs, Julie, additional, Chazan, Bibiana, additional, Yanovskay, Anna, additional, Ami, Ronen Ben, additional, Landes, Michal, additional, Nesher, Lior, additional, Zaidman-Shimshovitz, Adi, additional, McCarthy, Kate, additional, Paterson, David L, additional, Tacconelli, Evelina, additional, Buhl, Michael, additional, Mauer, Susanna, additional, Rodriguez-Bano, Jesus, additional, Morales, Isabel, additional, Oliver, Antonio, additional, Ruiz de Gopegui, Enrique, additional, Cano, Angela, additional, Machuca, Isabel, additional, Gozalo-Marguello, Monica, additional, Martinez, Luis Martinez, additional, Gonzalez-Barbera, Eva M, additional, Alfaro, Iris Gomez, additional, Salavert, Miguel, additional, Beovic, Bojana, additional, Saje, Andreja, additional, Mueller-Premru, Manica, additional, Pagani, Leonardo, additional, Vitrat, Virginie, additional, Kofteridis, Diamantis, additional, Zacharioudaki, Maria, additional, Maraki, Sofia, additional, Weissman, Yulia, additional, Paul, Mical, additional, Dickstein, Yaakov, additional, Leibovici, Leonard, additional, and Yahav, Dafna, additional

Published
2021
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45. CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumonia e and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.

Author

Cañada-García, Javier E., Moure, Zaira, Sola-Campoy, Pedro J., Delgado-Valverde, Mercedes, Cano, María E., Gijón, Desirèe, González, Mónica, Gracia-Ahufinger, Irene, Larrosa, Nieves, Mulet, Xavier, Pitart, Cristina, Rivera, Alba, Bou, Germán, Calvo, Jorge, Cantón, Rafael, González-López, Juan José, Martínez-Martínez, Luis, Navarro, Ferran, Oliver, Antonio, and Palacios-Baena, Zaira R.

Subjects
KLEBSIELLA pneumoniae, ESCHERICHIA coli, MOLECULAR cloning, MICROBIAL sensitivity tests, SINGLE nucleotide polymorphisms, NUCLEOTIDE sequencing
Abstract

Objectives: CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain. Methods: In total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis. Results: In total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were bla OXA–48 (263/377), bla KPC–3 (62/377), bla VIM–1 (28/377), and bla NDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5). Conclusion: This study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement

Author

Rivera, Alba, primary, Sánchez, Alba, additional, Luque, Sonia, additional, Mur, Isabel, additional, Puig, Lluís, additional, Crusi, Xavier, additional, González, José Carlos, additional, Sorlí, Luisa, additional, González, Aránzazu, additional, Horcajada, Juan Pablo, additional, Navarro, Ferran, additional, and Benito, Natividad, additional

Published
2020
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48. Do Prosthetic Joint Infections Worsen the Functional Ambulatory Outcome of Patients with Joint Replacements? A Retrospective Matched Cohort Study

Author

Mur, Isabel, primary, Jordán, Marcos, additional, Rivera, Alba, additional, Pomar, Virginia, additional, González, José Carlos, additional, López-Contreras, Joaquín, additional, Crusi, Xavier, additional, Navarro, Ferran, additional, Gurguí, Mercè, additional, and Benito, Natividad, additional

Published
2020
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49. Efficacy of Ceftolozane-Tazobactam in Combination with Colistin against Extensively Drug-Resistant Pseudomonas aeruginosa, Including High-Risk Clones, in an In Vitro Pharmacodynamic Model

Author

Montero, María, primary, Domene Ochoa, Sandra, additional, López-Causapé, Carla, additional, VanScoy, Brian, additional, Luque, Sonia, additional, Sorlí, Luisa, additional, Campillo, Núria, additional, Angulo-Brunet, Ariadna, additional, Padilla, Eduardo, additional, Prim, Núria, additional, Pomar, Virginia, additional, Rivera, Alba, additional, Grau, Santiago, additional, Ambrose, Paul G., additional, Oliver, Antonio, additional, and Horcajada, Juan P., additional

Published
2020
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50. Eventos cardiovasculares posterior a cirugía ortopédica ¿Quién está en riesgo?

Author

Vela Jiménez, Tania Jaqueline, Tulcanaza Ochoa, Galo Fernando, Buele Sánchez, Martha Nataly, Verdezoto Unaucho, Gissele Stephanie, Quisiguiña Cárdenas, Sofía Belén, Albarracín Revelo, Carlos Emilio, Paredes Rivera, Alba Soledad, Ochoa Crespo, María Teresa, and Domínguez Freire, Nervo David

Subjects
MEDICAL personnel, MUSCULOSKELETAL system injuries, ORTHOPEDIC surgery, SPINAL surgery, HEART metabolism disorders, HIP joint
Abstract

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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