98 results on '"Ritu Gill"'
Search Results
2. Editorial: Emerging contaminants and their effect on agricultural crops
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M. Naeem, Ritu Gill, Sarvajeet Singh Gill, Kashmir Singh, Adriano Sofo, and Narendra Tuteja
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agricultural crops ,climate change ,climatic factors ,emerging contaminants ,nitrogen and phosphorus nutrient cycling ,particularly polyethylene ,Plant culture ,SB1-1110 - Published
- 2023
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3. Editorial: Frontiers in malaria research
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Ritu Gill, Rachna Hora, Mahmood M. Alam, Abhisheka Bansal, Tarun Kumar Bhatt, and Ashwani Sharma
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malaria ,Plasmodium ,antimalarials ,malaria control and elimination ,malaria vaccine ,cytoadherence ,Microbiology ,QR1-502 - Published
- 2023
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4. Marker-Free Rice (Oryza sativa L. cv. IR 64) Overexpressing PDH45 Gene Confers Salinity Tolerance by Maintaining Photosynthesis and Antioxidant Machinery
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Ranjan Kumar Sahoo, Renu Tuteja, Ritu Gill, Juan Francisco Jiménez Bremont, Sarvajeet Singh Gill, and Narendra Tuteja
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antioxidants ,reactive oxygen species ,oxidative stress ,marker-free transgenic rice ,mature seed-derived calli ,pea DNA helicase 45 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Helicases function as key enzymes in salinity stress tolerance, and the role and function of PDH45 (pea DNA helicase 45) in stress tolerance have been reported in different crops with selectable markers, raising public and regulatory concerns. In the present study, we developed five lines of marker-free PDH45-overexpressing transgenic lines of rice (Oryza sativa L. cv. IR64). The overexpression of PDH45 driven by CaMV35S promoter in transgenic rice conferred high salinity (200 mM NaCl) tolerance in the T1 generation. Molecular attributes such as PCR, RT-PCR, and Southern and Western blot analyses confirmed stable integration and expression of the PDH45 gene in the PDH45-overexpressing lines. We observed higher endogenous levels of sugars (glucose and fructose) and hormones (GA, zeatin, and IAA) in the transgenic lines in comparison to control plants (empty vector (VC) and wild type (WT)) under salt treatments. Furthermore, photosynthetic characteristics such as net photosynthetic rate (Pn), stomatal conductance (gs), intercellular CO2 (Ci), and chlorophyll (Chl) content were significantly higher in transgenic lines under salinity stress as compared to control plants. However, the maximum primary photochemical efficiency of PSII, as an estimated from variable to maximum chlorophyll a fluorescence (Fv/Fm), was identical in the transgenics to that in the control plants. The activities of antioxidant enzymes, such as catalase (CAT), ascorbate peroxidase (APX), glutathione reductase (GR), and guaiacol peroxidase (GPX), were significantly higher in transgenic lines in comparison to control plants, which helped in keeping the oxidative stress burden (MDA and H2O2) lesser on transgenic lines, thus protecting the growth and photosynthetic efficiency of the plants. Overall, the present research reports the development of marker-free PDH45-overexpressing transgenic lines for salt tolerance that can potentially avoid public and biosafety concerns and facilitate the commercialization of genetically engineered crop plants.
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- 2022
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5. DNA Damage and Repair in Plants under Ultraviolet and Ionizing Radiations
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Sarvajeet S. Gill, Naser A. Anjum, Ritu Gill, Manoranjan Jha, and Narendra Tuteja
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Technology ,Medicine ,Science - Abstract
Being sessile, plants are continuously exposed to DNA-damaging agents present in the environment such as ultraviolet (UV) and ionizing radiations (IR). Sunlight acts as an energy source for photosynthetic plants; hence, avoidance of UV radiations (namely, UV-A, 315–400 nm; UV-B, 280–315 nm; and UV-C,
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- 2015
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6. Genome-Wide Collation of the Plasmodium falciparum WDR Protein Superfamily Reveals Malarial Parasite-Specific Features.
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Priyanka Chahar, Manjeri Kaushik, Sarvajeet Singh Gill, Surendra Kumar Gakhar, Natrajan Gopalan, Manish Datt, Amit Sharma, and Ritu Gill
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Medicine ,Science - Abstract
Despite a significant drop in malaria deaths during the past decade, malaria continues to be one of the biggest health problems around the globe. WD40 repeats (WDRs) containing proteins comprise one of the largest and functionally diverse protein superfamily in eukaryotes, acting as scaffolds for assembling large protein complexes. In the present study, we report an extensive in silico analysis of the WDR gene family in human malaria parasite Plasmodium falciparum. Our genome-wide identification has revealed 80 putative WDR genes in P. falciparum (PfWDRs). Five distinct domain compositions were discovered in Plasmodium as compared to the human host. Notably, 31 PfWDRs were annotated/re-annotated on the basis of their orthologs in other species. Interestingly, most PfWDRs were larger as compared to their human homologs highlighting the presence of parasite-specific insertions. Fifteen PfWDRs appeared specific to the Plasmodium with no assigned orthologs. Expression profiling of PfWDRs revealed a mixture of linear and nonlinear relationships between transcriptome and proteome, and only nine PfWDRs were found to be stage-specific. Homology modeling identified conservation of major binding sites in PfCAF-1 and PfRACK. Protein-protein interaction network analyses suggested that PfWDRs are highly connected proteins with ~1928 potential interactions, supporting their role as hubs in cellular networks. The present study highlights the roles and relevance of the WDR family in P. falciparum, and identifies unique features that lay a foundation for further experimental dissection of PfWDRs.
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- 2015
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7. Comparative Study of CNN Architectures For Driver Drowsiness.
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Bhawna Jain, Archana Yadav, and Ritu Gill
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- 2023
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8. Genomic collation revealed the significance of Piriformospora indica (Serendipita indica) PiEF-hand protein in vesicle trafficking and fungal hyphal growth
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Punam Kundu, Ashima Nehra, Ritu Gill, Narendra Tuteja, and Sarvajeet Singh Gill
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Plant Science - Published
- 2022
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9. Comprehensive genomic insight deciphers significance of EF-hand gene family in foxtail millet [Setaria italica (L.) P. Beauv.]
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Ashima Nehra, Punam Kundu, Kirti Ahlawat, Ashmita Chhikara, Niraj Agarwala, Narendra Tuteja, Sarvajeet Singh Gill, and Ritu Gill
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Plant Science - Published
- 2022
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10. Unraveling the importance of EF-hand-mediated calcium signaling in plants
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Punam Kundu, Ashima Nehra, Ritu Gill, Narendra Tuteja, and Sarvajeet Singh Gill
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Plant Science - Published
- 2022
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11. Virtual Residency Interviews- A Survival Guide and Lessons Learnt
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Aparna Komarraju, Eddy Zandee Van Rilland, and Ritu Gill
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Radiology, Nuclear Medicine and imaging - Published
- 2023
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12. Information Warfare: Lessons in Inoculation to Disinformation
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Meghan Fitzpatrick, Ritu Gill, and Jennifer F. Giles
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History ,Sociology and Political Science ,Political Science and International Relations ,Safety Research ,Social Sciences (miscellaneous) - Published
- 2022
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13. Effects of nanoparticles on the plant growth under salinity stress conditions
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null Deepa, Punam Kundu, Gopal Kalwan, Ritu Gill, Nar Singh Chauhan, and Sarvajeet Singh Gill
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- 2023
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14. Phytoremediation and Management of Environmental Contaminants: An Overview
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Ritu Gill, M. Naeem, A. A. Ansari, and Sarvajeet Singh Gill
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- 2023
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15. Impact of nanoparticles on agriculture and soil: an introduction
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null Deepa, Ashima Nehra, Gopal Kalwan, Ritu Gill, Nar Singh Chauhan, and Sarvajeet Singh Gill
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- 2023
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16. Phytoremediation and Management of Environmental Contaminants: Conclusion and Future Perspectives
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Ritu Gill, M. Naeem, A. A. Ansari, and Sarvajeet Singh Gill
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- 2023
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17. Contributors
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Muhammad Abrar, Faheem Ahmed, Syed Azmal Ali, Latefa Hamdan Almansoori, Muhammad Aqeel, Jaya Arora, Nishat Arshi, Aditi Arya, Umair Ashraf, Fatima Batool, Nar Singh Chauhan, Prabhat K. Chauhan, Dixita Chettri, Hemraj Chhipa, null Deepa, Sapana Garg, Sarvajeet Singh Gill, Ritu Gill, Sonia Goel, Sapna Grewal, Sabira Hafeez, Noureddine Issaoui, Shruti Jain, Josef Jampílek, Abhishek Joshi, Gopal Kalwan, Monika Kamari, Katarina Kráľová, Naveen Kumar, Shalendra Kumar, Suresh Kumar, Arpna Kumari, Punam Kundu, Sammina Mahmood, Saglara Mandzhieva, Tatiana Minkina, David E. Motaung, Ghulam M. Mustafa, Hummera Nawaz, Asiya Nazir, Ashima Nehra, Y. Prashanthi, Vishnu D. Rajput, Gita Rani, Anuj Ranjan, Tentu Nageswara Rao, Swasti Rawal, Muhammad Naveed Shahid, Bhaskar Sharma, Pinki Sharma, Parul Singh, Udit Soni, Svetlana Sushkova, Muhammad Tahir, Sudhir K. Upadhya, and Anil Kumar Verma
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- 2023
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18. Plant Adaptation to Environmental Change: Significance of Amino Acids and their Derivatives
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Naser A Anjum, Sarvajeet Singh Gill, Ritu Gill, Naser A Anjum, Sarvajeet Singh Gill, Ritu Gill
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- 2014
19. Virtual Image-based Biopsy of Lung Metastases: The Promise of Radiomics
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Ritu Gill
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Lung Neoplasms ,Biopsy ,Humans ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies - Published
- 2023
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20. Understanding the Role of Jasmonic Acid in Growth, Development, and Stress Regulation in Plants
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Pooja Jha, Ritu Sharaya, Punam Kundu, Ashmita Chhikara, Shruti Kaushik, Anmol Sidhu, Geetika Sirhindi, M. Naeem, Ritu Gill, and Sarvajeet Singh Gill
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- 2022
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21. Erdheim-Chester Disease: Multisystem involvement
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Ritu Gill and Christina Konstantopoulos
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medicine.medical_specialty ,business.industry ,Erdheim–Chester disease ,Medicine ,business ,medicine.disease ,Dermatology - Published
- 2020
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22. The multifaceted histone chaperone RbAp46/48 in Plasmodium falciparum: structural insights, production, and characterization
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S. K. Gakhar, Sarvajeet Singh Gill, Ritu Gill, Ashima Nehra, and Manjeri Kaushik
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Protein Conformation ,Recombinant Fusion Proteins ,Protein subunit ,Plasmodium falciparum ,Protozoan Proteins ,Gene Expression ,Chromatin remodeling ,Histones ,Histone H4 ,Histone Chaperones ,RBBP4 ,Amino Acid Sequence ,Cell Nucleus ,Life Cycle Stages ,General Veterinary ,biology ,General Medicine ,Chromatin ,Cell biology ,Infectious Diseases ,Histone ,Insect Science ,Chaperone (protein) ,biology.protein ,Parasitology ,Nuclear localization sequence ,Protein Binding - Abstract
RbAp46/RBBP7 and RbAp48/RBBP4 are WD40-repeat histone chaperones and chromatin adaptors that reside in multiple complexes involved in maintenance of chromatin structure. RbAp48 is the essential subunit of the chromatin assembly factor-1 (CAF-1) complex, therefore also named as CAF-1C. A detailed in silico sequence and structure analysis of homologs of RbAp46/48 in Plasmodium falciparum (PF3D7_0110700 and PF3D7_1433300) exhibited conservation of characteristic features in both the protein-seven-bladed WD40 β-propeller conformation and different binding interfaces. A comparative structural analysis highlighted species-specific features of the parasite, yeast, drosophila, and human RbAp46/48. In the present study, we report cloning, expression, and characterization of P. falciparum PF3D7_0110700, a putative RbAp46/48 (PfRbAp46/48). PfRbAp46/48 was cloned into pTEM11 vector in fusion with 6xHistidine tag and over-expressed in Escherichia coli B834 cells. The protein was purified by Ni-NTA followed by gel permeation chromatography. The protein expressed in all the three asexual blood stages and exhibited nuclear localization. We showed direct interaction of the purified rPfRbAp46/48 with the histone H4. These findings further our understanding of RbAp46/48 proteins and role of these proteins in the parasite biology.
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- 2020
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23. The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non–Small Cell Lung Cancer
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John G. Edwards, Kari Chansky, Paul Van Schil, Andrew G. Nicholson, Souheil Boubia, Elisabeth Brambilla, Jessica Donington, Françoise Galateau-Sallé, Hans Hoffmann, Maurizio Infante, Mirella Marino, Edith M. Marom, Jun Nakajima, Marcin Ostrowski, William D. Travis, Ming-Sound Tsao, Yasushi Yatabe, Dorothy J. Giroux, Lynn Shemanski, John Crowley, Marc Krasnik, Hisao Asamura, Ramón Rami-Porta, Valerie Rusch, Luiz Henrique Araujo, David Beer, Pietro Bertoglio, Ricardo Beyruti, Andrea Bille, Vanessa Bolejack, James D. Brierley, A.K. Cangir, David Carbone, Gail Darling, Frank Detterbeck, Xavier Benoit D’Journo, Jessica Donnington, Wilfried Eberhardt, John Edwards, Jeremy Erasmus, Conrad Falkson, Wentao Fang, Dean Fennell, Kwun Fong, Françoise Galateau-Salle, Oliver Gautschi, Ritu Gill, Dorothy Giroux, Meredith Giuliani, Jin Mo Goo, Seiki Hasegawa, Fred Hirsch, Hans Hoffman, Wayne Hofstetter, James Huang, Philippe Joubert, Kemp Kernstine, Keith Kerr, Young Tae Kim, Hong Kwan Kim, Hedy Kindler, Yolande Lievens, Hui Liu, Donald E. Low, Gustavo Lyons, Heber MacMahon, Edith Marom, José-María Matilla, Jan van Meerbeeck, Luis M. Montuenga, Andrew Nicholson, Katie Nishimura, Anna Nowak, Isabelle Opitz, Meinoshin Okumura, Raymond U. Osarogiagbon, Harvey Pass, Marc de Perrot, Helmut Prosch, David Rice, Andreas Rimner, Enrico Ruffini, Shuji Sakai, Navneet Singh, Amy Stoll-D’Astice, Francisco Su´rez, Ricardo M. Terra, Ming S. Tsao, Paula Ugalde, David Waller, Shun-ichi Watanabe, Jacinta Wiens, Ignacio Wistuba, Liyan Jiang, Kaoru Kubota, Akif Turna, Benny Weksler, Maria Teresa Tzukazan, Martin Tammemägi, Charles Powell, David Naidich, Hongxu Liu, Samuel Armato, Alex Brunelli, Giuseppe Cardillo, Elizabeth David, Brigitte Fournier, Mark Krasnik, Kauro Kubota, Catherine Labbe, Eric Lim, Paul Martin Putora, Gaetano Rocco, Pier Luigi Filosso, Kazuya Kondo, Dong Kwan Kim, Giuseppe Giaccone, Marco Lucchi, Thomas Rice, Mark Ferguson, Prasad Adsusmilli, William Travis, Francisco Suárez, Kaura Kubota, Hisao Asamura Shun-ichi, Watanabe, Edith Marom Ramón, Rami-Porta, Ming Tsao, Ming Tsao Shun-ichi, Watanabe, Meredith Guiliani, James Brierley, Ricardo Terra, Ray Osarogiagbon, Luis Montuenga, Hongwei Wang, Françoise Galateau, Jim Mo Goo, Bill Travis, Jose Maria Matilla, Carolle St. Pierre, Ma Teresa Tzukazan, Nicholas Girard, Andreas Rimmer, Francoise Galateau, Prasad Adusumilli, Xavier D’Journo, Donald Low, Adam Rosenthal, and Int Assoc Study Lung Canc Staging
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0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Neoplasm, Residual ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Cytology ,medicine ,Humans ,Lung cancer ,Biology ,Lymph node ,Neoplasm Staging ,Retrospective Studies ,Computer. Automation ,business.industry ,Carcinoma in situ ,Margins of Excision ,Prognosis ,medicine.disease ,Clinical trial ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Resection margin ,Human medicine ,Radiology ,Non small cell ,Lung cancer staging ,business ,Mathematics - Abstract
Objective: Our aim was to validate the prognostic relevance in NSCLC of potential residual tumor (R) descriptors, including the proposed International Association for the Study of Lung Cancer definition for uncertain resection, referred to as R(un). Methods: A total of 14,712 patients undergoing resection with full R status and survival were analyzed. The following were also evaluated: whether fewer than three N2 stations were explored, lobe-specific nodal dissection, extracapsular extension, highest lymph node station status, carcinoma in situ at the bronchial resection margin, and pleural lavage cytologic examination result. Revised categories of R0, R(un), R1, and R2 were tested for survival impact. Results: In all, 14,293 cases were R0, 263 were R1, and 156 were R2 (median survivals not reached, 33 months, and 29 months, respectively). R status correlated with T and N categories. A total of 9290 cases (63%) had three or more N2 stations explored and 6641 cases (45%) had lobespecific nodal dissection, correlated with increasing pN2. Extracapsular extension was present in 62 of 364 cases with available data (17%). The highest station was positive in 942 cases (6.4%). The pleural lavage cytologic examination result was positive in 59 of 1705 cases (3.5%): 13 had carcinoma in situ at the bronchial resection margin. After reassignment because of inadequate nodal staging in 56% of cases, 6070 cases were R0, 8185 were R(un), 301 were R1, and 156 were R2. In node-positive cases, the median survival times were 70, 50, and 30 months for RO, R(un) (p < 0.0001), and R1 (p < 0.001), respectively, with no significant difference between RO and R(un) in pN0 cases. Conclusions: R descriptors have prognostic relevance, with R(un) survival stratifying between R0 and R1. Therefore, a detailed evaluation of R factor is of particular importance in the design and analyses of clinical trials of adjuvant therapies. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
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- 2020
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24. Genomic Glimpse of the Chromatin Modifier SET Domain family in Plasmodium falciparum
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Priyanka Chahar, Manjeri Kaushik, Ritu Gill, Naresh Kumar, and Ashima Nehra
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Infectious Diseases ,Histone ,Methyltransferase ,biology ,Ubiquitin ,Histone lysine methylation ,Acetylation ,biology.protein ,SUMO protein ,Computational biology ,Methylation ,Chromatin - Abstract
Histones N-terminal tails are the sites for Post-Translational Modifications (PTMs) that regulate the chromatin structure, thus chromatin associated processes. PTMs include methylation, acetylation, phosphorylation, ubiquitination, sumoylation, and ribosylation. Histone lysine methylation is associated with both transcription activation and repression. The SET domain proteins carry out the histone lysine methylation on the N-terminal tails of histones H3 and H4 and are called Histone Lysine Methyltransferases (HKMTs). A total of ten SET domain genes have been identified in human malarial parasite Plasmodium falciparum. The present study provides detailed computational analysis of P. falciparum SET domain proteins (PfSETs). The analyses cover PfSET family in terms of domain composition, physiochemical properties, subcellular localization, expression profiling and phylogenetic relationships. The work also highlights the conservation of important catalytic residues in PfSETs. The present study provides a detailed insight into the PfSET family, thus opens a platform for further developments. How to cite this article:Kaushik M, Chahar P, Nehra A, Kumar N, Gill R. Genomic Glimpse of the Chromatin Modifier SET Domain family in Plasmodium falciparum. J Commun Dis 2019; 51(4): 29-40. DOI: https://doi.org/10.24321/0019.5138.201934
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- 2020
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25. Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis-Associated Bronchiectasis: Role of RA-related Autoantibodies
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Gregory McDermott, Ritu Gill, Staci Gagne, Suzanne Byrne, Weixing Huang, Xiaosong Wang, Lauren C. Prisco, Alessandra Zaccardelli, Lily W. Martin, Lucy Masto, Vanessa L. Kronzer, Nancy Shadick, Paul F. Dellaripa, Tracy J. Doyle, and Jeffrey A. Sparks
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Arthritis, Rheumatoid ,Rheumatology ,Risk Factors ,Case-Control Studies ,Immunology ,Immunology and Allergy ,Humans ,Lung Diseases, Interstitial ,Life Style ,Article ,Autoantibodies ,Bronchiectasis ,Demography - Abstract
Objective.To investigate demographic, lifestyle, and serologic risk factors for isolated rheumatoid arthritis (RA)–associated bronchiectasis (RA-BR) that is not a result of interstitial lung disease (ILD).Methods.We performed a case-control study using patients with RA from the Mass General Brigham Biobank. We reviewed the records of all patients with RA meeting the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology criteria with computed tomography (CT) chest imaging to identify RA-BR cases and controls with RA and RA-related lung disease. For each patient, the CT chest imaging that was performed closest to enrollment was independently reviewed by 2 radiologists for the presence of RA-related lung diseases. Cases had clinical and radiologic evidence of RA-BR without interstitial lung abnormalities on imaging. Controls had RA and no evidence of bronchiectasis or ILD. We examined the associations between demographic, lifestyle, and serologic factors with RA-BR using multivariable logistic regression.Results.We identified 57 cases of isolated RA-BR and 360 RA controls without RA-related lung disease. In multivariable models, RA-BR was associated with older age at RA onset (OR 1.37 per 10 years, 95% CI 1.02–1.82), lower BMI at RA diagnosis (OR 0.94 per kg/m2, 95% CI 0.89–0.99), seropositive RA (OR 3.96, 95% CI 1.84–8.53), positive rheumatoid factor (OR 4.40, 95% CI 2.14–9.07), and positive anticyclic citrullinated peptide (OR 3.47, 95% CI 1.65–7.31). Higher titers of RA-related autoantibodies were associated with higher odds of RA-BR.Conclusion.Seropositivity, older age at RA diagnosis, and lower BMI at RA onset were associated with isolated bronchiectasis in RA that was not a result of ILD. These findings expand the list of potential risk factors for RA-BR and suggest a pathogenic link between airway inflammation and RA-related autoantibodies.
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- 2022
26. Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset
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Gregory McDermott, Ritu Gill, Staci Gagne, Suzanne Byrne, Weixing Huang, Jing Cui, Lauren Prisco, Alessandra Zaccardelli, Lily Martin, Vanessa L Kronzer, Matthew Moll, Michael H Cho, Nancy Shadick, Paul F Dellaripa, Tracy Doyle, and Jeffrey A Sparks
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Male ,Middle Aged ,Mucin-5B ,Arthritis, Rheumatoid ,Logistic Models ,Rheumatology ,Basic Science ,Odds Ratio ,Disease Progression ,Humans ,Pharmacology (medical) ,Female ,Lung Diseases, Interstitial ,Promoter Regions, Genetic - Abstract
Objectives To investigate the associations of the common MUC5B promoter variant with timing of RA-associated interstitial lung disease (RA-ILD) and RA onset. Methods We identified patients with RA meeting 2010 ACR/EULAR criteria and available genotype information in the Mass General Brigham Biobank, a multihospital biospecimen and clinical data collection research study. We determined RA-ILD presence by reviewing all RA patients who had CT imaging, lung biopsy or autopsy results. We determined the dates of RA and RA-ILD diagnoses by manual records review. We examined the associations of the MUC5B promoter variant (G>T at rs35705950) with RA-ILD, RA-ILD occurring before or within 2 years of RA diagnosis and RA diagnosis at age >55 years. We used multivariable logistic regression to estimate odds ratios (ORs) for each outcome by MUC5B promoter variant status, adjusting for potential confounders including genetic ancestry and smoking. Results We identified 1005 RA patients with available genotype data for rs35705950 (mean age 45 years, 79% female, 81% European ancestry). The MUC5B promoter variant was present in 155 (15.4%) and was associated with RA-ILD [multivariable OR 3.34 (95% CI 1.97, 5.60)], RA-ILD before or within 2 years of RA diagnosis [OR 4.01 (95% CI 1.78, 8.80)] and RA onset after age 55 years [OR 1.52 (95% CI 1.08, 2.12)]. Conclusions The common MUC5B promoter variant was associated with RA-ILD onset earlier in the RA disease course and older age of RA onset. These findings suggest that the MUC5B promoter variant may impact RA-ILD risk early in the RA disease course, particularly in patients with older-onset RA.
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- 2022
27. An overview of the hazardous and trace materials in soil and plants
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Abid Ali Ansari, Sarvajeet Singh Gill, Tariq Aftab, Rukhsar Parwez, Ritu Gill, and M. Naeem
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- 2022
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28. Impact of Agrochemicals on Soil Microbiota
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Shiv Kumar Giri, Neha Verma, Gulab Singh, Ritu Gill, and Anil Kumar
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- 2022
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29. Agrochemicals in Soil and Environment: Conclusions and Future Perspectives
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Ritu Gill, M. Naeem, A. A. Ansari, Ashmita Chhikara, Juan Francisco Jiménez Bremont, Narendra Tuteja, and Sarvajeet Singh Gill
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- 2022
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30. List of contributors
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Tariq Aftab, Niraj Agarwala, Imran Ahmad, Muhammad Ahsan, Hazrat Ali, Abid Ali Ansari, Behnam Asgari Lajayer, Tess Astatkie, Pooja Moni Baruah, Gabriel Basílico, Zahra Biglari Quchan Atigh, Nar Singh Chauhan, Kankan Datta, Laura de Cabo, Nasser Delangiz, Neha Dogra, Muhammad Faisal, Zahra Gerami, Mahesh R. Ghule, Ritu Gill, Sarvajeet Singh Gill, Arash Hemati, Gabriela Iglesias, Muhammad Ijaz, Naila Inayat, Valeria Ionno, Shamiya Jahan, Moazzam Jamil, Gurvarinder Kaur, Shruti Kaushik, Zahra Kazemi, Chetan Keswani, Kavita Khatana, Masoumeh Kordi, Anil Kumar, Isha Madaan, Abdul Majeed, Ehsan Mofidi Chelan, Ebrahim Moghiseh, Mohammad Mosaferi, Zahir Muhammad, M. Naeem, Muhammad Nafees, Jitendra K. Nagar, Bouzid Nedjimi, Khatereh Nobaharan, Melisa S. Olivelli, Ramachandra Reddy Pamuru, Deepu Pandita, Aparna Pareek, Rukhsar Parwez, Kanu Priya, Farhan Rafiq, Purushottam K. Ramteke, Rajiv Ranjan, Sheela Rautela, Dipanjali Ray, Muhammad Ammar Raza, Anees Ur Rehman, Aryadeep Roychoudhury, Ayesha Sadiqa, Geetanjali Sageena, Robab Salami, Abdul Sattar, Muhammad Shahid, Bisma Shahzadi, Ahmad Sher, Anmol Sidhu, Ankur Singh, Ayushi Singh, Geetika Sirhindi, Saloni Soni, Parul Tyagi, Sami Ul-Allah, Kaleem Ullah, Rehman Ullah, Neha Verma, Monika Yadav, and Adnan Younis
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- 2022
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31. Agrochemicals in Soil and Environment: An Overview
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Ritu Gill, M. Naeem, A. A. Ansari, Anil Kumar, Ajit Kumar, Ashmita Chhikara, Juan Francisco Jiménez Bremont, Narendra Tuteja, and Sarvajeet Singh Gill
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- 2022
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32. Plants and microbes assisted remediation of cadmium-contaminated soil
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Neha Verma, Ritu Gill, Kanu Priya, and Anil Kumar
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- 2022
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33. Heavy metal toxicity and underlying mechanisms for heavy metal tolerance in medicinal legumes
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Rukhsar Parwez, M. Naeem, Tariq Aftab, Abid Ali Ansari, Sarvajeet Singh Gill, and Ritu Gill
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- 2022
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34. Fine Specificity Protein Antibodies and Prediction of Rheumatoid Arthritis-Associated Interstitial Lung Disease
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Vanessa Kronzer, Keigo Hayashi, Kazuki Yoshida, John M. Davis, Gregory McDermott, Weixing Huang, Paul Dellaripa, Jing Cui, Vivi Feathers, Ritu Gill, Hiroto Hatabu, Mizuki Nishino, Rachel Blaustein, Cynthia S. Crowson, William Robinson, jeremy sokolove, Katherine Liao, Michael Weinblatt, Nancy Shadick, Tracy Doyle, and Jeffrey A. Sparks
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- 2022
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35. Approaches for identification and analysis of plant circular RNAs and their role in stress responses
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Gopal Kalwan, Sarvajeet Singh Gill, Parichita Priyadarshini, Ritu Gill, Yashwant K. Yadava, Sheel Yadav, Pooja Moni Baruah, Niraj Agarwala, Kishor Gaikwad, and Pradeep Kumar Jain
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Plant Science ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
- Full Text
- View/download PDF
36. Genome-wide analysis of various paralogs of aminopeptidase N (APN) gene in Anopheles gambiae (Diptera: Culicidae)
- Author
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Ritu Gill
- Subjects
Plant Science ,Agronomy and Crop Science ,General Biochemistry, Genetics and Molecular Biology ,Food Science - Published
- 2019
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37. Undergraduate radiology in low- and middle-income countries (LMICs)
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Meghavi Mashar, Abu Aboiye, Morgan Sehdev, David Launer, Mariame Sylla, Ruchir Mashar, Natalie Posever, Jessy Jindal, Aparna Komarraju, and Ritu Gill
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Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2022
- Full Text
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38. Phytoremediation : Management of Environmental Contaminants, Volume 7
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Lee Newman, Abid Ali Ansari, Sarvajeet Singh Gill, M. Naeem, Ritu Gill, Lee Newman, Abid Ali Ansari, Sarvajeet Singh Gill, M. Naeem, and Ritu Gill
- Subjects
- Biology—Technique, Agricultural biotechnology, Soil science, Botanical chemistry, Plant diseases
- Abstract
The accumulation of large amounts of contaminants occurs in the environment due to industrialization and various other anthropogenic activities. Contaminants ultimately affect human health worldwide. Organic, inorganic, and radioactive substances are the prevalent forms of environmental contaminants and their complete remediation in soils and sediments is rather a difficult task. Concerns of their toxicities led to the emphasis on development of effective techniques to assess the presence and mobility of contaminants in air, water, and soil. Furthermore, the ever-increasing concentration of toxic pollutants in the environment is considered a serious threat to plant, animal, human, and environmental health.Many technologies are in use to clean and eliminate hazardous contaminants from the environment; however, these technologies can be costly, labor intensive, and often distressing to the general public. Phytoremediation is a simple, cost effective, environmentally friendly and fast-emerging new technology for eliminating toxic contaminants from different environments. Phytoremediation refers to the natural ability of certain plants and their associated microbiome (including hyper-accumulators or bio-accumulators) to remove, degrade, or render contaminants harmless. Through this technique, certain species of plants flourish by accumulating contaminants present in the environment. The unique and selective uptake capabilities of plant root and shoot systems, effective translocation, bioaccumulation, and contaminant degradation capabilities of the accumulator plants are utilized in phytoremediation techniques. Phytotechnologies involving the use of plants for contaminant removal gained importance during the last two decades and phytoremediation technology became an effective tool for environmental detoxification because of plants ability to accumulate the contaminants at very high concentrations.Phytoremediation strategies can remove, degrade, or stabilize inorganic and organic contaminants entering a multitude of ecosystems using green plants and their associated microbial communities. The development and use of phytotechnologies continues to move forward at a steady pace. Researchers recognize the potential of phytoremediation to offer a green, cost effective, eco-friendly and feasible application to address some of the world's many environmental challenges. This book provides significant information to add to the previous volumes published on the topic and can serve as the foundation for the development of new applications that feature the integration of modern research discoveries into new methods to remediate contaminated ecosystems. Moreover, this volume brings recent and established knowledge on different aspects of phytoremediation and nano-phytoremediation, providing this information in a single source that offers a cutting-edge synthesis of scientific and experiential knowledge on polluted environments that is useful for policy makers, practitioners and scientists, and engineers.Phytoremediation: Management of Environmental Contaminants, Volume 7 highlights the various prospects that are involved in current global phytoremediation research. This book delivers a content-rich source to the reader and can act as a platform for further research studies. It should meet the needs of all researchers working in, or have an interest in this particular field.
- Published
- 2023
39. Biostimulants in Alleviation of Metal Toxicity in Plants : Emerging Trends and Opportunities
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Sarvajeet Singh Gill, Narendra Tuteja, Nafees A Khan, Ritu Gill, Sarvajeet Singh Gill, Narendra Tuteja, Nafees A Khan, and Ritu Gill
- Abstract
Biostimulants in Alleviation of Metal Toxicity in Plants: Emerging Trends and Opportunities focuses on the role of substances or micro-organisms whose presence can address issues of metal contamination in soils, seeds and plants. Including a range of biostimulant tools, the book highlights both endogenous and exogenous application. Written and edited by a global team of experts, this book presents an overview on biostimulants in determining metal toxicity. As plants encounter a wide range of environmental challenges during their lifecycle, among which metal toxicity is a common form of abiotic stress, this book thoroughly covers important topics on the subject matter. Once inside a plant system, toxic metals may initiate a variety of physiological alterations in plants, including adversely impacted seed germination, root and shoot growth, chloroplasts ultrastructure and photosynthesis, nutrients assimilation, carbohydrates metabolism, and plant hormonal status which, collectively, results in reduced plants yields. In addition to several naturally occurring physiological and metabolic re-programing responses, plants may also modify their root and shoot systems in order to dilute entered amount of toxic metals. As an additional tool biostimulants have emerged as one of the important plant protectors under adverse conditions. - Includes endogenous and exogenous application of biostimulants - Focuses on use based on specific metal contamination - Presents forward-looking prospects for the use of biostimulants in plant health protection
- Published
- 2023
40. Comparative genomic analysis reveals evolutionary and structural attributes of MCM gene family in Arabidopsis thaliana and Oryza sativa
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Ritu Gill, Narendra Tuteja, Sarvajeet Singh Gill, Anca Macovei, Priyanka Chahar, Abid Ali Ansari, and Sandeep Yadav
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0106 biological sciences ,0301 basic medicine ,Subfamily ,Protein family ,Arabidopsis ,Bioengineering ,Computational biology ,01 natural sciences ,Applied Microbiology and Biotechnology ,03 medical and health sciences ,Gene Expression Regulation, Plant ,010608 biotechnology ,Gene duplication ,Gene family ,Phylogeny ,Synteny ,Plant Proteins ,biology ,DNA replication ,Oryza ,General Medicine ,Genomics ,biology.organism_classification ,030104 developmental biology ,Licensing factor ,Multigene Family ,Biotechnology - Abstract
The mini-chromosome maintenance (MCM) family, a large and functionally diverse protein family belonging to the AAA+ superfamily, is essential for DNA replication in all eukaryotic organisms. The MCM 2-7 form a hetero-hexameric complex which serves as licensing factor necessary to ensure the proper genomic DNA replication during the S phase of cell cycle. MCM 8-10 are also associated with the DNA replication process though their roles are particularly unclear. In this study, we report an extensive in silico analysis of MCM gene family (MCM 2-10) in Arabidopsis and rice. Comparative analysis of genomic distribution across eukaryotes revealed conservation of core MCMs 2-7 while MCMs 8-10 are absent in some taxa. Domain architecture analysis underlined MCM 2-10 subfamily specific features. Phylogenetic analyses clustered MCMs into 9 clades as per their subfamily. Duplication events are prominent in plant MCM family, however no duplications are observed in Arabidopsis and rice MCMs. Synteny analysis among Arabidopsis thaliana, Oryza sativa, Glycine max and Zea mays MCMs demonstrated orthologous relationships and duplication events. Further, estimation of synonymous and non-synonymous substitution rates illustrated evolution of MCM family under strong constraints. Expression profiling using available microarray data and qRT-PCR revealed differential expression under various stress conditions, hinting at their potential use to develop stress resilient crops. Homology modeling of Arabidopsis and rice MCM 2-7 and detailed comparison with yeast MCMs identified conservation of eukaryotic specific insertions and extensions as compared to archeal MCMs. Protein-protein interaction analysis revealed an extensive network of putative interacting partners mainly involved in DNA replication and repair. The present study provides novel insights into the MCM family in Arabidopsis and rice and identifies unique features, thus opening new perspectives for further targeted analyses.
- Published
- 2020
41. Unraveling CAF-1 family in Plasmodium falciparum: comparative genome-wide identification and phylogenetic analysis among eukaryotes, expression profiling and protein–protein interaction studies
- Author
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Ashima Nehra, Ritu Gill, Manjeri Kaushik, and Sarvajeet Singh Gill
- Subjects
Subfamily ,Phylogenetic tree ,biology ,In silico ,Plasmodium falciparum ,Computational biology ,Environmental Science (miscellaneous) ,biology.organism_classification ,Agricultural and Biological Sciences (miscellaneous) ,Genome ,Gene expression profiling ,Proteome ,Gene ,Biotechnology - Abstract
The present research reports a detailed in silico analysis of chromatin assembly factor-1 (CAF-1) family in human malaria parasite Plasmodium falciparum. Our analysis revealed five chromatin assembly factor-1 genes in P. falciparum (PfCAF-1) and the PfCAF-1 family was divided into two classes where, Class A belongs to the CAF-1 complex and others are kept in Class B. For comparative studies, orthologs of PfCAF-1 family were identified across 53 eukaryotic species and evolutionary relationships were drawn for different CAF-1 subfamilies. The phylogenetic analysis revealed grouping of evolutionary-related species together, although, divergence was observed in branching pattern. A detailed analysis of domain composition highlighted species-specific features viz. species-specific KDDS repeats of 84 amino acids were identified in PfCAF-1A whereas, members of CAF-1C/RbAp48 and RbAp46 subfamily exhibited least variation in size and domain composition. The qRT-PCR analysis revealed upregulation of PfCAF-1 members in trophozoite or schizont stage. Furthermore, a comparative expression analysis of the available transcriptome and proteome data along with qRT-PCR analysis revealed mixed expression patterns (coordination as well as non-coordination between different studies). Protein–protein interaction network analyses of PfCAF-1 family were carried out highlighting important complexes based on interologs. The PfRbAp48 was found to be highly connected with a total of 108 PPIs followed by PfRbAp46. The results unravel insights into the PfCAF-1 family and identify unique features, thus opening new perspectives for further targeted developments to understand and combat malaria menace.
- Published
- 2020
- Full Text
- View/download PDF
42. Contributors
- Author
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Ruchi Agarrwal, Rosalyn B. Angeles-Shim, Alma Balestrazzi, Jyotsna Bharti, Amita Bhattacharya, Shashi Bhushan, Sudip Biswas, Abhishek Bohra, Amit Chawla, Sagar Chhabra, Karabi Datta, Swapan K. Datta, Sabrina M. Elias, Murugesh Eswaran, Ana Margarida Fortes, Chiara Forti, Maraeva Gianella, Ritu Gill, Sarvajeet Singh Gill, Carla Gualtieri, Priyanka Gupta, Filippo Guzzon, Umme Habiba, Taslima Haque, Mirza Hasanuzzaman, Nurnabi A. Jewel, Gopaljee Jha, Rintu Jha, Rashmi Kaul, Tanushri Kaul, Pushpa Kharb, Ajay Kohli, Amit Kumar, Arvind Kumar, Pramod Kumar, Sanjay Kumar, Punam Kundu, Anca Macovei, Shuvobrata Majumder, Alok Kumar Maurya, Reyazul Rouf Mir, Vishnu Mishra, Andrea Mondoni, Khaled Fathy Abdel Motelb, Suresh Nair, Himani Negi, Ashima Nehra, Ramsong C. Nongpiur, Isaiah Catalino M. Pabuayon, Andrea Pagano, Ashwani Pareek, Nishat Passricha, Diana Pimentel, Arul T. Prakash, Ram Prasad, Nitya Meenakshi Raman, Mamta Rani, Prosanta Saha, Shabnam K. Saifi, Nitika Sandhu, Neelam S. Sangwan, Ananda K. Sarkar, Shabari Sarkar Das, Zeba I. Seraj, Mohammad Umer Sharif Shohan, Krishan Kant Sharma, Ram Kumar Sharma, Pramod Kumar Singh, Rakshita Singh, Sanatsujat Singh, Sneh Lata Singla-Pareek, Alok Krishna Sinha, Sonia Khan Sony, Susana de Sousa Araújo, Yashdeep Srivastava, Tabassum R. Sunfi, Jennylyn L. Trinidad, Narendra Tuteja, Renu Tuteja, Kriti Tyagi, Rajeev K. Varshney, Neetu Verma, Rachana Verma, Ashish Warghat, Sandeep Yadav, and Shailesh Yadav
- Published
- 2020
- Full Text
- View/download PDF
43. Reactive oxygen species (ROS) management in engineered plants for abiotic stress tolerance
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Mirza Hasanuzzaman, Ritu Gill, Krishan Kant Sharma, Sarvajeet Singh Gill, Ram Prasad, Ashima Nehra, Narendra Tuteja, and Punam Kundu
- Subjects
chemistry.chemical_classification ,Abiotic component ,Reactive oxygen species ,Abiotic stress ,fungi ,food and beverages ,Metal toxicity ,Biology ,medicine.disease_cause ,Salinity ,Global population ,chemistry ,Agronomy ,Crop loss ,medicine ,Oxidative stress - Abstract
The global population is continuously increasing, and it is expected to be about 9 billion by 2050. However, the agriculturally important land area is decreasing due to urbanization and other developmental activities. Further, the crop loss due to several constraints such as salinity, drought, chilling stress, and high metal toxicity is significantly extended by the changing climatic conditions. The abiotic stresses pose additional burdens of oxidative stress in plants through excessive production of reactive oxygen species (ROS), which cause considerable damage to the cell biomolecules (nucleic acid and proteins). Therefore, understanding ROS production under stress and its scavenging machinery is very important to engineer plants to withstand the stress burden without much yield penalty.
- Published
- 2020
- Full Text
- View/download PDF
44. Epigenetic regulation of heat and cold stress responses in crop plants
- Author
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Neha Verma, Shiv Kumar Giri, Gulab Singh, Ritu Gill, and Anil Kumar
- Subjects
Genetics ,Plant Science ,Biochemistry ,Biotechnology - Published
- 2022
- Full Text
- View/download PDF
45. Canada’s Civil–Military Seminar: An Approach to Narrowing the Civil–Military Gap
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Megan M. Thompson, Tonya Hendriks, Ritu Gill, Kelly Piasentin, Tara Holton, and Angela R Febbraro
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021110 strategic, defence & security studies ,Sociology and Political Science ,Political economy ,05 social sciences ,050602 political science & public administration ,0211 other engineering and technologies ,Civil–military relations ,02 engineering and technology ,Safety Research ,Social Sciences (miscellaneous) ,0506 political science - Abstract
The “civil–military gap” is a significant factor that can hinder the success of complex comprehensive approach missions. Perhaps nowhere is this gap more apparent than in the relationship between m...
- Published
- 2018
- Full Text
- View/download PDF
46. COVID-19 Disinformation: A Multi-National, Whole of Society Perspective
- Author
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Ritu Gill, Rebecca Goolsby, Ritu Gill, and Rebecca Goolsby
- Subjects
- COVID-19 Pandemic, 2020-, Disinformation, COVID-19 Pandemic, 2020- , in mass media
- Abstract
The COVID-19 pandemic is not only a threat to our health and economy, but also has strong implications for defence and security. Indeed, defence leaders have highlighted a second fight surrounding the spread of COVID-19, namely disinformation and preparing to face adversaries willing to exploit the public health crisis for nefarious purposes. The current pandemic is a breeding ground for the propagation of disinformation, as it represents the first major global health event in which large social media platforms have become the main distributor of information. This multi-national edited volume consists of contributions from Defence Science, academia and industry, including NATO Headquarters, United States, Netherlands, Singapore, United Kingdom and Norway. The content is aimed at a diverse audience, including NATO members, researchers from defence and security organizations, academics, and militaries including analysts and practitioners, as well as policy makers. This volume focuses onvarious aspects of COVID-19 disinformation, including identifying global dominant disinformation narratives and the methods used to spread disinformation, examining COVID-19 disinformation within the broader context of the cognitive domain, examining the psychological effects of COVID-19 disinformation and COVID-19 disinformation on instant messaging platforms, along with examining various countermeasures to disinformation.
- Published
- 2022
47. Unraveling CAF-1 family in
- Author
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Manjeri, Kaushik, Ashima, Nehra, Sarvajeet Singh, Gill, and Ritu, Gill
- Subjects
Original Article - Abstract
The present research reports a detailed in silico analysis of chromatin assembly factor-1 (CAF-1) family in human malaria parasite Plasmodium falciparum. Our analysis revealed five chromatin assembly factor-1 genes in P. falciparum (PfCAF-1) and the PfCAF-1 family was divided into two classes where, Class A belongs to the CAF-1 complex and others are kept in Class B. For comparative studies, orthologs of PfCAF-1 family were identified across 53 eukaryotic species and evolutionary relationships were drawn for different CAF-1 subfamilies. The phylogenetic analysis revealed grouping of evolutionary-related species together, although, divergence was observed in branching pattern. A detailed analysis of domain composition highlighted species-specific features viz. species-specific KDDS repeats of 84 amino acids were identified in PfCAF-1A whereas, members of CAF-1C/RbAp48 and RbAp46 subfamily exhibited least variation in size and domain composition. The qRT-PCR analysis revealed upregulation of PfCAF-1 members in trophozoite or schizont stage. Furthermore, a comparative expression analysis of the available transcriptome and proteome data along with qRT-PCR analysis revealed mixed expression patterns (coordination as well as non-coordination between different studies). Protein–protein interaction network analyses of PfCAF-1 family were carried out highlighting important complexes based on interologs. The PfRbAp48 was found to be highly connected with a total of 108 PPIs followed by PfRbAp46. The results unravel insights into the PfCAF-1 family and identify unique features, thus opening new perspectives for further targeted developments to understand and combat malaria menace. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13205-020-2096-7) contains supplementary material, which is available to authorized users.
- Published
- 2019
48. Phytoremediation : Management of Environmental Contaminants, Volume 6
- Author
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Abid A. Ansari, Sarvajeet Singh Gill, Ritu Gill, Guy R. Lanza, Lee Newman, Abid A. Ansari, Sarvajeet Singh Gill, Ritu Gill, Guy R. Lanza, and Lee Newman
- Subjects
- Environmental management, Phytoremediation, Pollutants
- Abstract
This text details the plant-assisted remediation method, “phytoremediation”, which involves the interaction of plant roots and associated rhizospheric microorganisms for the remediation of soil contaminated with high levels of metals, metalloids, fuel and oil hydrocarbons, nano particles, pesticides, solvents, organic compounds and various other contaminants. Many chapters highlight and compare the efficiency and economic advantages of phytoremediation and nano-phytoremediation to currently practiced soil and water treatment practices.Volume 6 of Phytoremediation: Management of Environmental Contaminants continues the series. Taken together, the six volumes provide a broad–based global synopsis of the current applications of phytoremediation using plants and the microbial communities associated with their roots to decontaminate terrestrial and aquatic ecosystems.
- Published
- 2019
49. A Multicenter Study of Volumetric Computed Tomography for Staging Malignant Pleural Mesothelioma
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Valerie W. Rusch, Ritu Gill, Alan Mitchell, David Naidich, David C. Rice, Harvey I. Pass, Hedy L. Kindler, Marc De Perrot, Joseph Friedberg, Michelle Ginsberg, Jeremy Erasmus, Samuel Armato, Christopher Strauss, Wickii Vigneshwaran, Sharyn Katz, Marc de Perrot, Demetrios Patios, Dori Giroux, and Lynn Shemanski
- Subjects
Male ,Mesothelioma ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Databases, Factual ,Pleural Neoplasms ,Disease-Free Survival ,Article ,030218 nuclear medicine & medical imaging ,Imaging modalities ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Survival analysis ,Aged ,Neoplasm Staging ,Pathologic stage ,Electronic network ,business.industry ,Pleural mesothelioma ,Mesothelioma, Malignant ,Cone-Beam Computed Tomography ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Tumor Burden ,Volumetric Computed Tomography ,Multicenter study ,030220 oncology & carcinogenesis ,Female ,Surgery ,Radiology ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business - Abstract
Background Standard imaging modalities are inaccurate in staging malignant pleural mesothelioma (MPM). Single-institution studies suggest that volumetric computed tomography (CT) is more accurate but labor intensive. We established a multicenter network to test interobserver variability, accuracy (relative to pathologic stage), and the prognostic significance of semiautomated volumetric CT. Methods Six institutions electronically submitted to an established multicenter database clinical and pathologic data for patients with MPM who had operations. Institutional radiologists reviewed preoperative CT scans for quality and then submitted by electronic network (AG Mednet, www.agmednet.com) to the biostatistical center. Two reference radiologists blinded to clinical data performed semiautomated tumor volume calculations using Vitrea Enterprise 6.0 software (Vital Images, Minnetonka, MN) and then submitted readings to the biostatistical center. Study end points included feasibility of the network, interobserver variability for volumetric CT, correlation of tumor volume to pTN stages, and overall survival (OS). Results Of 164 patients, the CT scans for 129 were analyzable and read by reference radiologists. Most tumors were less than 500 cm 3 . A small bias was observed between readers because one provided consistently larger measurements than the other (mean difference, 47.9; p = .0027), but for 80%, the absolute difference was 200 cm 3 or less. Spearman correlation between readers was 0.822. Volume correlated with pTN stages and OS, best defined by three groups with average volumes of 91.2, 245.3, and 511.3 cm 3 associated with median OS of 37, 18, and 8 months, respectively. Conclusions For the first time, a multicenter network was established and initial correlations of tumor volume with pTN stages and OS are shown. A larger multicenter international study is planned to confirm the results and refine correlations.
- Published
- 2016
- Full Text
- View/download PDF
50. Unraveling the multifaceted histone chaperone RbAp46/48 in Plasmodium falciparum
- Author
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Ashima Nehra, Sarvajeet Singh Gill, Ritu Gill, and Manjeri Kaushik
- Subjects
Microbiology (medical) ,Infectious Diseases ,Histone ,biology ,Chaperone (protein) ,biology.protein ,lcsh:RC109-216 ,Plasmodium falciparum ,General Medicine ,biology.organism_classification ,lcsh:Infectious and parasitic diseases ,Cell biology - Published
- 2020
- Full Text
- View/download PDF
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