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1. Co-circulation of Influenza A H5, H7, and H9 Viruses and Co-infected Poultry in Live Bird Markets, Cambodia

Author

Horwood, Paul F., Horm, Srey Viseth, Suttie, Annika, Thet, Sopheak, Y., Phalla, Rith, Sareth, Sorn, San, Holl, Davun, Tum, Sothyra, Ly, Sowath, Karlsson, Erik A., Tarantola, Arnaud, and Dussart, Philippe

Subjects
Avian influenza -- Health aspects, Infection -- Health aspects, Poultry industry -- Health aspects, Avian influenza viruses -- Health aspects, Health
Abstract

A large variety of avian influenza viruses (AIVs) circulate in live bird markets (LBMs) in countries where highly pathogenic influenza A(H5N1) viruses are endemic (1). The low pathogenicity AIVs A(H7N9) [...]

Published
2018
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2. Safety, potential efficacy, and pharmacokinetics of specific polyclonal immunoglobulin F(ab')2 fragments against avian influenza A (H5N1) in healthy volunteers: a single-centre, randomised, double-blind, placebo-controlled, phase 1 study

Author

Bal, Céline, Herbreteau, Cécile H, Buchy, Philippe, Rith, Sareth, Zaid, Masliza, Kristanto, William, Han, Velda, Reynaud, Charlotte, Granjard, Patrick, Lépine, Bertrand, Durand, Caroline, and Tambyah, Paul A

Published
2015
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3. Seroprevalence and transmission of human influenza A(H5N1) virus before and after virus reassortment, Cambodia, 2006-2014

Author

Ly, Sowath, Horwood, Paul, Chan, Malen, Rith, Sareth, Sorn, Sopheak, Oeung, Kunthea, Nguon, Kunthy, Chan, Siam, Y, Phalla, Parry, Amy, Tsuyuoka, Reiko, Ly, Sovann, Richner, Beat, Laurent, Denis, Vong, Sirenda, Dussart, Philippe, Buchy, Philippe, and Tarantola, Arnaud

Subjects
Avian influenza -- Research, Infection -- Research, Avian influenza viruses, Health
Abstract

Human influenza A(H5N1) virus infections in Cambodia were first detected in January 2005. Twenty-one cases, including 19 (90.5%) deaths, were reported during 2005-2012. In January 2013, researchers at the Institut [...]

Published
2017
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4. Aerosol exposure of live bird market workers to viable influenza A/ H5N1 and A/ H9N2 viruses, Cambodia

Author

Horwood, Paul F., primary, Horm, Srey Viseth, additional, Yann, Sokhoun, additional, Tok, Songha, additional, Chan, Malen, additional, Suttie, Annika, additional, Y, Phalla, additional, Rith, Sareth, additional, Siegers, Jurre Y., additional, San, Sorn, additional, Davun, Holl, additional, Tum, Sothyra, additional, Ly, Sowath, additional, Tarantola, Arnaud, additional, Dussart, Philippe, additional, and Karlsson, Erik A., additional

Published
2022
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6. Dynamic of H5N1 virus in Cambodia and emergence of a novel endemic sub-clade

Author

Sorn, San, Sok, Touch, Ly, Sovann, Rith, Sareth, Tung, Nguyen, Viari, Alain, Gavotte, Laurent, Holl, Davun, Seng, Heng, Asgari, Nima, Richner, Beat, Laurent, Denis, Chea, Nora, Duong, Veasna, Toyoda, Tetsuya, Yasuda, Chadwick Y., Kitsutani, Paul, Zhou, Paul, Bing, Sun, Deubel, Vincent, Donis, Ruben, Frutos, Roger, and Buchy, Philippe

Published
2013
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8. Aerosol exposure of live bird market workers to viable influenza A/H5N1 and A/H9N2 viruses, Cambodia.

Author

Horwood, Paul F., Horm, Srey Viseth, Yann, Sokhoun, Tok, Songha, Chan, Malen, Suttie, Annika, Y, Phalla, Rith, Sareth, Siegers, Jurre Y., San, Sorn, Davun, Holl, Tum, Sothyra, Ly, Sowath, Tarantola, Arnaud, Dussart, Philippe, and Karlsson, Erik A.

Subjects
AVIAN influenza, AVIAN influenza A virus, AEROSOLS, AIR sampling apparatus, INFLUENZA, EGGS
Abstract

Live bird markets (LBMs) have been identified as key factors in the spread, persistence and evolution of avian influenza viruses (AIVs). In addition, these settings have been associated with human infections with AIVs of pandemic concern. Exposure to aerosolised AIVs by workers in a Cambodian LBM was assessed using aerosol impact samplers. LBM vendors were asked to wear an air sampler for 30 min per day for 1 week while continuing their usual activities in the LBM during a period of high AIV circulation (February) and a period of low circulation (May). During the period of high circulation, AIV RNA was detected from 100% of the air samplers using molecular methods and viable AIV (A/H5N1 and/or A/H9N2) was isolated from 50% of air samplers following inoculation into embryonated chicken eggs. In contrast, AIV was not detected by molecular methods or successfully isolated during the period of low circulation. This study demonstrates the increased risk of aerosol exposure of LBM workers to AIVs during periods of high circulation and highlights the need for interventions during these high‐risk periods. Novel approaches, such as environmental sampling, should be further explored at key high‐risk interfaces as a potentially cost‐effective alternative for monitoring pandemic threats. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia

Author

Moncla, Louise H., primary, Bedford, Trevor, additional, Dussart, Philippe, additional, Horm, Srey Viseth, additional, Rith, Sareth, additional, Buchy, Philippe, additional, Karlsson, Erik A., additional, Li, Lifeng, additional, Liu, Yongmei, additional, Zhu, Huachen, additional, Guan, Yi, additional, Friedrich, Thomas C., additional, and Horwood, Paul F., additional

Published
2020
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13. Transmission experiments support clade-level differences in the transmission and pathogenicity of Cambodian influenza A/H5N1 viruses

Author

Horwood, Paul F., primary, Fabrizio, Thomas, additional, Horm, Srey Viseth, additional, Metlin, Artem, additional, Ros, Sopheaktra, additional, Tok, Songha, additional, Jeevan, Trushar, additional, Seiler, Patrick, additional, Y, Phalla, additional, Rith, Sareth, additional, Suttie, Annika, additional, Buchy, Philippe, additional, Karlsson, Erik A., additional, Webby, Richard, additional, and Dussart, Philippe, additional

Published
2020
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14. Circulation and characterization of seasonal influenza viruses in Cambodia, 2012‐2015

Author

Horwood, Paul F., primary, Karlsson, Erik A., additional, Horm, Srey Viseth, additional, Ly, Sovann, additional, Heng, Seng, additional, Chin, Savuth, additional, Darapheak, Chau, additional, Saunders, David, additional, Chanthap, Lon, additional, Rith, Sareth, additional, Y, Phalla, additional, Chea, Kim Lay, additional, Sar, Borann, additional, Parry, Amy, additional, Ieng, Vanra, additional, Tsuyouka, Reiko, additional, Deng, Yi‐Mo, additional, Hurt, Aeron C., additional, Barr, Ian G., additional, Komadina, Naomi, additional, Buchy, Philippe, additional, and Dussart, Philippe, additional

Published
2019
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15. Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia

Author

Moncla, Louise H., primary, Bedford, Trevor, additional, Dussart, Philippe, additional, Horm, Srey Viseth, additional, Rith, Sareth, additional, Buchy, Philippe, additional, Karlsson, Erik A, additional, Li, Lifeng, additional, Liu, Yongmei, additional, Zhu, Huachen, additional, Guan, Yi, additional, Friedrich, Thomas C., additional, and Horwood, Paul F., additional

Published
2019
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16. Genetic diversity of human rhinoviruses in Cambodia during a three-year period reveals novel genetic types

Author

Roger Frutos, Sirenda Vong, Vincent Deubel, Emmanuel Cornillot, Monica Naughtin, Anne-Charlotte Sentilhes, Philippe Buchy, Francis Delpeyroux, Rith Sareth, and Marie-Line Joffret

Subjects
Male, Rhinovirus, Range (biology), Virologie, viruses, Picornaviridae, Genetic diversity, Génétique des populations, Nasopharynx, Genotype, Phylogeny, Respiratory tract infections, Coinfection, virus diseases, Infectious Diseases, S50 - Santé humaine, Female, medicine.symptom, Human rhinoviruses, Cambodia, Genre humain, Microbiology (medical), Séquence nucléotidique, Period (gene), Molecular Sequence Data, Severe disease, Genome, Viral, Biology, Microbiology, Asymptomatic, Article, Variation génétique, Maladie de l'homme, Genetics, medicine, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, ComputingMethodologies_COMPUTERGRAPHICS, Picornaviridae Infections, Sequence Analysis, RNA, Picornavirus, Genetic Variation, Virology, Multiplex pcrs, Multiplex Polymerase Chain Reaction
Abstract

Graphical abstract, Highlights • Five novel genotypes are identified based on VP1 sequences. • Co-infections with other viruses is demonstrated. • The genome of rhinoviruses is saturated. • A novel classification system considering amino acid sequences should be developed., Acute respiratory viral infections are a major cause of morbidity during early childhood in developing countries. Human rhinoviruses are the most frequent cause of upper respiratory tract infections in humans, which can range in severity from asymptomatic to clinically severe disease. In this study we collected 4170 nasopharyngeal swabs from patients hospitalised with influenza-like illness in two Cambodian provincial hospitals between 2007 and 2010. Samples were screened for 18 respiratory viruses using 5 multiplex PCRs. A total of 11.2% of samples tested positive for human rhinoviruses (HRV). VP4/2 and VP1 regions were amplified and sequenced to study the distribution of rhinoviruses genotypes and species in Cambodia during this three-year period. Five novel genotypes, 2 species A, 2 species B and 1 species C were identified based on VP1 sequences. Co-infections with other viruses were demonstrated.

Published
2015

18. Environmental contamination and risk factors for transmission of highly pathogenic avian influenza A(H5N1) to humans, Cambodia, 2006-2010

Author

Ly, Sowath, primary, Vong, Sirenda, additional, Cavailler, Philippe, additional, Mumford, Elizabeth, additional, Mey, Channa, additional, Rith, Sareth, additional, Van Kerkhove, Maria D., additional, Sorn, San, additional, Sok, Touch, additional, Tarantola, Arnaud, additional, and Buchy, Philippe, additional

Published
2016
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19. Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia

Author

Timmermans, Ans, primary, Melendrez, Melanie C., additional, Se, Youry, additional, Chuang, Ilin, additional, Samon, Nou, additional, Uthaimongkol, Nichapat, additional, Klungthong, Chonticha, additional, Manasatienkij, Wudtichai, additional, Thaisomboonsuk, Butsaya, additional, Tyner, Stuart D., additional, Rith, Sareth, additional, Horm, Viseth Srey, additional, Jarman, Richard G., additional, Bethell, Delia, additional, Chanarat, Nitima, additional, Pavlin, Julie, additional, Wongstitwilairoong, Tippa, additional, Saingam, Piyaporn, additional, El, But Sam, additional, Fukuda, Mark M., additional, Touch, Sok, additional, Sovann, Ly, additional, Fernandez, Stefan, additional, Buchy, Philippe, additional, Chanthap, Lon, additional, and Saunders, David, additional

Published
2016
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20. Intense circulation of A/H5N1 and other avian influenza viruses in Cambodian live-bird markets with serological evidence of sub-clinical human infections

Author

Horm, Srey Viseth, primary, Tarantola, Arnaud, additional, Rith, Sareth, additional, Ly, Sowath, additional, Gambaretti, Juliette, additional, Duong, Veasna, additional, Y, Phalla, additional, Sorn, San, additional, Holl, Davun, additional, Allal, Lotfi, additional, Kalpravidh, Wantanee, additional, Dussart, Philippe, additional, Horwood, Paul F, additional, and Buchy, Philippe, additional

Published
2016
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21. Acute Viral Lower Respiratory Tract Infections in Cambodian Children: clinical and epidemiologic characteristics

Author

Sophie Goyet, Charles Mayaud, Arnaud Tarantola, Rith Sareth, Philippe Buchy, Philippe Cavailler, Vantha Te, Patrich Lorn Try, Gilles Guerrier, Bertrand Guillard, Eak Tep Chheng, Sirenda Vong, Laurence Borand, Blandine Rammaert, Institut Pasteur du Cambodge, Institut Pasteur du Cambodge-Réseau International des Instituts Pasteur ( RIIP ), National Paediatric Hospital, Université Sorbonne Paris Cité ( USPC ), Takeo Provincial hospital, CHU Tenon [APHP], Kampong Cham Provincial hospital, Kampong Cham Provincial hospital [Cambodia], This study was supported by Surveillance and Investigation of Epidemic Situations in Southeast Asia (SISEA) project., Réseau International des Instituts Pasteur (RIIP), Université Sorbonne Paris Cité (USPC), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), National pediatric hospital, Centre d'infectiologie Necker-Pasteur, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Donkeo Provincial Hospital, Epidémiologie & Santé Publique (epi@ipc), and Institut Pasteur du Cambodge-Réseau International des Instituts Pasteur ( RIIP ) -Institut Pasteur du Cambodge-Réseau International des Instituts Pasteur ( RIIP )

Subjects
Male, Pediatrics, Respiratory pathogens, viruses, Multiplex polymerase chain reaction, Treatment outcome, MESH : Prospective Studies, [ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH : Child, Preschool, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH : Pneumonia, Viral, MESH : Female, Prospective Studies, 030212 general & internal medicine, Respiratory system, Prospective cohort study, MESH: Treatment Outcome, Pediatric, 0303 health sciences, MESH : Viruses, Respiratory tract infections, Coinfection, MESH: Infant, Newborn, MESH : Infant, MESH: Infant, MESH : Bronchiolitis, Viral, 3. Good health, Virus, [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Treatment Outcome, Infectious Diseases, Child, Preschool, Viruses, Female, Seasons, Cambodia, Microbiology (medical), medicine.medical_specialty, MESH: Bronchiolitis, Viral, MESH : Male, Pneumonia, Viral, MESH : Treatment Outcome, MESH : Infant, Newborn, MESH: Viruses, 03 medical and health sciences, medicine, Bronchiolitis, Viral, Humans, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, MESH : Seasons, 030306 microbiology, business.industry, MESH : Cambodia, MESH: Cambodia, MESH: Child, Preschool, MESH : Humans, Infant, Newborn, Infant, Pneumonia, medicine.disease, Infant newborn, MESH: Male, MESH: Prospective Studies, MESH: Coinfection, MESH : Coinfection, MESH: Pneumonia, Viral, Pediatrics, Perinatology and Child Health, business, MESH: Seasons, MESH: Female, [ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract

International audience; BACKGROUND: : Viruses are detected in most hospitalized children admitted for acute respiratory infections. Etiologic understanding is needed to improve clinical management and prevention, particularly in resource-limited tropical countries. METHODS: : A 3-year prospective descriptive study was conducted among Cambodian children admitted to 2 provincial hospitals for acute lower respiratory tract infection. Molecular detection for 18 viral pathogens using multiplex polymerase chain reaction/reverse transcription polymerase chain reactions was performed. RESULTS: : We enrolled 1006 children less than 5 years of age of whom 423 (42%), 428 (42%) and 155 (16%) had pneumonia, bronchiolitis and unclassified lower respiratory tract infections, respectively. Of the 551 (55%) with documented viral infection, a single virus was detected in 491 (89%), including rhinovirus (n = 169; 34%), respiratory syncytial virus (n = 167; 34%), parainfluenza virus (n = 40; 8%), human metapneumovirus (n = 39; 8%), influenza virus (n = 31; 6%), bocavirus (n = 16; 3%), adenovirus (n = 15; 3%), coronavirus (n = 9; 2%) and enterovirus (n = 5; 1%). Coinfections with multiple viruses were detected in 6% (2 viruses detected in 59 cases; 3 viruses detected in 1 case). CONCLUSION: : Similar to other tropical countries, rhinovirus and respiratory syncytial virus were the principal viral pathogens detected among children hospitalized for lower tract respiratory infection in Cambodia.

Published
2013
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22. Serologic evidence of human influenza virus infections in swine populations, Cambodia

Author

Rith, Sareth, Netrabukkana, Punnaporn, Sorn, San, Mumford, Elizabeth, Mey, Channa, Holl, Davun, Goutard, Flavie, Y, Bunthin, Fenwick, Stan, Robertson, Ian, Roger, François, Buchy, Philippe, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Division of Health Sciences, School of Veterinary and Biomedical Sciences-Murdoch University, Department of Animal Health Production, National Veterinary Research Institute-Ministry of Agriculture Forestry and Fisheries, Global Influenza Programme, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Animal et gestion intégrée des risques (UPR AGIRs), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), This study was supported by a grant from the World Health Organization, Geneva, by the Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services and by Murdoch University., Rith S, Netrabukkana P, Roger F, Buchy P., Sorn S, Mumford E, Mey C, Holl D, Goutard F, Y B, Fenwick S, and Robertson I

Subjects
Male, pig, Swine, viruses, serology, Part 1, L73 - Maladies des animaux, Antibodies, Viral, Porcin, Influenza A Virus, H1N1 Subtype, Orthomyxoviridae Infections, Seroepidemiologic Studies, Zoonoses, Immunologie, Influenza, Human, Animals, Humans, Influenzavirus aviaire, Transmission des maladies, Swine Diseases, Influenza A Virus, H5N1 Subtype, Anticorps, Influenza A Virus, H3N2 Subtype, virus diseases, Original Articles, respiratory tract diseases, influenza A viruses, S50 - Santé humaine, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Original Article, Cambodia, Genre humain
Abstract

International audience; Background This study was conducted from 2006 to 2010 and investigated the seroprevalence of influenza A viruses in Cambodian pigs, including human H1N1, H3N2, 2009 pandemic H1N1 (A(H1N1)pdm09), and highly pathogenic avian H5N1 influenza A viruses. Methods A total of 1147 sera obtained from pigs in Cambodia were tested by haemagglutination inhibition (HI) assays for antibody to human influenza A viruses along with both HI and microneutralization (MN) tests to assess immunological responses to H5N1 virus. The results were compared by year, age, and province. Results Antibodies against a human influenza A virus were detected in 14*9% of samples. A(H1N1)pdm09 virus were dominant over the study period (23*1%), followed by those to human H1N1 (17*3%) and H3N2 subtypes (9*9%). No pigs were serologically positive for avian H5 influenza viruses. The seroprevalence of human H1N1 and H3N2 influenza viruses peaked in 2008, while that of A(H1N1)pdm09 reached a peak in 2010. No significant differences in seroprevalence to human influenza subtypes were observed in different age groups. Conclusions Cambodian pigs were exposed to human strains of influenza A viruses either prior to or during this study. The implications of these high prevalence rates imply human-to-swine influenza virus transmission in Cambodia. Although pigs are mostly raised in small non-commercial farms, our preliminary results provide evidence of sustained human influenza virus circulation in pig populations in Cambodia.

Published
2012
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23. Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013

Author

Rith, Sareth, primary, Davis, C. Todd, additional, Duong, Veasna, additional, Sar, Borann, additional, Horm, Srey Viseth, additional, Chin, Savuth, additional, Ly, Sovann, additional, Laurent, Denis, additional, Richner, Beat, additional, Oboho, Ikwo, additional, Jang, Yunho, additional, Davis, William, additional, Thor, Sharmi, additional, Balish, Amanda, additional, Iuliano, A. Danielle, additional, Sorn, San, additional, Holl, Davun, additional, Sok, Touch, additional, Seng, Heng, additional, Tarantola, Arnaud, additional, Tsuyuoka, Reiko, additional, Parry, Amy, additional, Chea, Nora, additional, Allal, Lotfi, additional, Kitsutani, Paul, additional, Warren, Dora, additional, Prouty, Michael, additional, Horwood, Paul, additional, Widdowson, Marc-Alain, additional, Lindstrom, Stephen, additional, Villanueva, Julie, additional, Donis, Ruben, additional, Cox, Nancy, additional, and Buchy, Philippe, additional

Published
2014
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24. Epidemiological and Virological Characteristics of Influenza Viruses Circulating in Cambodia from 2009 to 2011

Author

Horm, Srey Viseth, primary, Mardy, Sek, additional, Rith, Sareth, additional, Ly, Sovann, additional, Heng, Seng, additional, Vong, Sirenda, additional, Kitsutani, Paul, additional, Ieng, Vannra, additional, Tarantola, Arnaud, additional, Ly, Sowath, additional, Sar, Borann, additional, Chea, Nora, additional, Sokhal, Buth, additional, Barr, Ian, additional, Kelso, Anne, additional, Horwood, Paul F., additional, Timmermans, Ans, additional, Hurt, Aeron, additional, Lon, Chanthap, additional, Saunders, David, additional, Ung, Sam An, additional, Asgari, Nima, additional, Roces, Maria Concepcion, additional, Touch, Sok, additional, Komadina, Naomi, additional, and Buchy, Philippe, additional

Published
2014
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25. Specific polyclonal F(ab’)2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice

Author

Herbreteau, Cécile Hélène, primary, Jacquot, Frédéric, additional, Rith, Sareth, additional, Vacher, Laurent, additional, Nguyen, Ludovic, additional, Carbonnelle, Caroline, additional, Lotteau, Vincent, additional, Jolivet, Michel, additional, Raoul, Hervé, additional, Buchy, Philippe, additional, and Saluzzo, Jean-François, additional

Published
2014
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26. 1482Sentinel Surveillance of Respiratory Viral Pathogens in Border Areas of Western Cambodia

Author

Chuang, Ilin, primary, Timmermans, Ans, additional, Melendrez, Melanie, additional, Se, Youry, additional, Nou, Samon, additional, Uthaimongkol, Nichapat, additional, Tyner, Stuart, additional, Rith, Sareth, additional, Jarman, Rick, additional, Bethell, Delia, additional, Chanarat, Nitima, additional, Pavlin, Julie, additional, Wongstitwilairoong, Tippa, additional, Saingam, Piyaporn, additional, Buth, Sam El, additional, Touch, Sok, additional, Heng, Seng, additional, Sovann, Ly, additional, Lon, Chanthap, additional, Fernandez, Stefan, additional, Buchy, Philippe, additional, and Saunders, David, additional

Published
2014
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27. Acute lower respiratory infections in ≥5 year -old hospitalized patients in Cambodia, a low-income tropical country: clinical characteristics and pathogenic etiology

Author

Vong, Sirenda, primary, Guillard, Bertrand, additional, Borand, Laurence, additional, Rammaert, Blandine, additional, Goyet, Sophie, additional, Te, Vantha, additional, Lorn Try, Patrich, additional, Hem, Sopheak, additional, Rith, Sareth, additional, Ly, Sowath, additional, Cavailler, Philippe, additional, Mayaud, Charles, additional, and Buchy, Philippe, additional

Published
2013
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29. A Study of the Genetic Variability of Human Respiratory Syncytial Virus (HRSV) in Cambodia Reveals the Existence of a New HRSV Group B Genotype

Author

Arnott, Alicia, primary, Vong, Sirenda, additional, Mardy, Sek, additional, Chu, Simon, additional, Naughtin, Monica, additional, Sovann, Ly, additional, Buecher, Carole, additional, Beauté, Julien, additional, Rith, Sareth, additional, Borand, Laurence, additional, Asgari, Nima, additional, Frutos, Roger, additional, Guillard, Bertrand, additional, Touch, Sok, additional, Deubel, Vincent, additional, and Buchy, Philippe, additional

Published
2011
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30. Influenza virus circulation in Cambodia

Author

Mardy, Sek, primary, Ly, Sovann, additional, Heng, Seng, additional, Naughtin, Monica, additional, Vong, Sirenda, additional, Kitsutani, Paul, additional, Huch, Chea, additional, Rith, Sareth, additional, Sar, Borann, additional, Nora, Chea, additional, Sokhal, Buth, additional, Yasuda, Chadwick, additional, Wierzba, Tom, additional, Asgari, Nima, additional, Touch, Sok, additional, and Buchy, Philippe, additional

Published
2011
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31. Identification of viruses in Acute Lower Respiratory Infections (ALRI) in Lao People's Democratic Republic

Author

Sentilhes, Anne-Charlotte, primary, Xaysitthideth, Vimatha, additional, Rith, Sareth, additional, Ongkhamme, Somvay, additional, Sisouk, Thongchanh, additional, Phonekeo, Darouny, additional, Bernatas, Jean-Jacques, additional, Deubel, Vincent, additional, Buchy, Philippe, additional, Brey, Paul, additional, and Vongphrachanh, Phengta, additional

Published
2011
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33. Acute lower respiratory infections in =5 year -old hospitalized patients in Cambodia, a low-income tropical country: clinical characteristics and pathogenic etiology.

Author

Vong, Sirenda, Guillard, Bertrand, Borand, Laurence, Rammaert, Blandine, Goyet, Sophie, Te, Vantha, Try, Patrich Lorn, Hem, Sopheak, Rith, Sareth, Ly, Sowath, Cavailler, Philippe, Mayaud, Charles, and Buchy, Philippe

Subjects
RESPIRATORY infections, VIRUS diseases, BACTERIAL diseases, ETIOLOGY of diseases, COMMUNITY-acquired infections
Abstract

Background: Few data exist on viral and bacterial etiology of acute lower respiratory infections (ALRI) in =5 year -old persons in the tropics. Methods: We conducted active surveillance of community-acquired ALRI in two hospitals in Cambodia, a low-income tropical country. Patients were tested for acid-fast bacilli (AFB) by direct sputum examination, other bacteria by blood and/or sputum cultures, and respiratory viruses using molecular techniques on nasopharyngeal/ throat swabs. Pulmonologists reviewed clinical/laboratory data and interpreted chest X-rays (CXR) to confirm ALRI. Results: Between April 2007 - December 2009, 1,904 patients aged =5 years were admitted with acute pneumonia (50.4%), lung sequelae-associated ALRI (24.3%), isolated pleural effusions (8.9%) or normal CXR-related ALRI (17.1%); 61 (3.2%) died during hospitalization. The two former diagnoses were predominantly due to bacterial etiologies while viral detection was more frequent in the two latter diagnoses. AFB-positive accounted for 25.6% of acute pneumonia. Of the positive cultures (16.8%), abscess-prone Gram-negative bacteria (39.6%) and Haemophilus influenzae (38.0%) were most frequent, followed by Streptococcus pneumoniae (17.7%). Of the identified viruses, the three most common viruses included rhinoviruses (49.5%), respiratory syncytial virus (17.7%) and influenza viruses (12.1%) regardless of the diagnostic groups. Wheezing was associated with viral identification (31.9% vs. 13.8%, p < 0.001) independent of age and time-to-admission. Conclusions: High frequency of H. influenzae and S. pneumoniae infections support the need for introduction of the respective vaccines in the national immunization program. Tuberculosis was frequent in patients with acute pneumonia, requiring further investigation. The relationship between respiratory viruses and wheezing merits further studies. [ABSTRACT FROM AUTHOR]

Published
2013
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34. Acute lower respiratory infections in ≥ 5 year -old hospitalized patients in Cambodia, a low-income tropical country: clinical characteristics and pathogenic etiology.

Author

Vong, Sirenda, Guillard, Bertrand, Borand, Laurence, Rammaert, Blandine, Goyet, Sophie, Te, Vantha, Lorn Try, Patrich, Hem, Sopheak, Rith, Sareth, Ly, Sowath, Cavailler, Philippe, Mayaud, Charles, and Buchy, Philippe

Abstract

Background: Few data exist on viral and bacterial etiology of acute lower respiratory infections (ALRI) in ≥ 5 year -old persons in the tropics.Methods: We conducted active surveillance of community-acquired ALRI in two hospitals in Cambodia, a low-income tropical country. Patients were tested for acid-fast bacilli (AFB) by direct sputum examination, other bacteria by blood and/or sputum cultures, and respiratory viruses using molecular techniques on nasopharyngeal/throat swabs. Pulmonologists reviewed clinical/laboratory data and interpreted chest X-rays (CXR) to confirm ALRI.Results: Between April 2007 - December 2009, 1,904 patients aged ≥5 years were admitted with acute pneumonia (50.4%), lung sequelae-associated ALRI (24.3%), isolated pleural effusions (8.9%) or normal CXR-related ALRI (17.1%); 61 (3.2%) died during hospitalization. The two former diagnoses were predominantly due to bacterial etiologies while viral detection was more frequent in the two latter diagnoses. AFB-positive accounted for 25.6% of acute pneumonia. Of the positive cultures (16.8%), abscess-prone Gram-negative bacteria (39.6%) and Haemophilus influenzae (38.0%) were most frequent, followed by Streptococcus pneumoniae (17.7%). Of the identified viruses, the three most common viruses included rhinoviruses (49.5%), respiratory syncytial virus (17.7%) and influenza viruses (12.1%) regardless of the diagnostic groups. Wheezing was associated with viral identification (31.9% vs. 13.8%, p  <  0.001) independent of age and time-to-admission.Conclusions: High frequency of H. influenzae and S. pneumoniae infections support the need for introduction of the respective vaccines in the national immunization program. Tuberculosis was frequent in patients with acute pneumonia, requiring further investigation. The relationship between respiratory viruses and wheezing merits further studies. [ABSTRACT FROM AUTHOR]

Published
2013
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