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222 results on '"Ritaccio, Anthony"'

6. Reflex Epilepsies

Author

Ritaccio, Anthony, Tatum, William O., editor, Sirven, Joseph I., editor, and Cascino, Gregory D., editor

Published
2021
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8. Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy.

Author

Zhao, Xiaofeng, Liao, Yuan, Morgan, Shannon, Mathur, Ramkumar, Feustel, Paul, Mazurkiewicz, Joseph, Qian, Jiang, Chang, Julia, Mathern, Gary W, Adamo, Matthew A, Ritaccio, Anthony L, Gruenthal, Michael, Zhu, Xinjun, and Huang, Yunfei

Subjects
Brain, Astrocytes, Microglia, Synapses, Lysosomes, Animals, Mice, Inbred C57BL, Mice, Knockout, Epilepsy, Recurrence, Inflammation, Inflammation Mediators, Chemokines, Signal Transduction, Cell Proliferation, Phagocytosis, Gene Deletion, Female, Male, TOR Serine-Threonine Kinases, Tuberous Sclerosis Complex 1 Protein, astrocyte, epilepsy, epileptogenesis, inflammation, lysosome, mTOR, microglia, seizure, synapse, tuberous sclerosis complex, Mice, Inbred C57BL, Knockout, Biochemistry and Cell Biology, Medical Physiology
Abstract

Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increased proliferation, and robust phagocytosis activity, but without a significant induction of pro-inflammatory cytokines. We further provide evidence that these noninflammatory changes in microglia disrupt homeostasis of the CNS, leading to reduced synapse density, marked microglial infiltration into hippocampal pyramidal layers, moderate neuronal degeneration, and massive proliferation of astrocytes. Moreover, the mice thus affected develop severe early-onset spontaneous recurrent seizures (SRSs). Therefore, we have revealed an epileptogenic mechanism that is independent of the microglial inflammatory response. Our data suggest that microglia could be an opportune target for epilepsy prevention.

Published
2018

13. Proceedings of the Eighth International Workshop on Advances in Electrocorticography

Author

Ritaccio, Anthony L, Williams, Justin, Denison, Tim, Foster, Brett L, Starr, Philip A, Gunduz, Aysegul, Zijlmans, Maeike, and Schalk, Gerwin

Subjects
Biomedical Research, Brain, Brain Mapping, Electrocorticography, Humans, Brain-computer interface, Responsive neurostimulation, High-frequency oscillations, Thalamocortical networks, Neuromodulation, Flexible electronics, Brain–computer interface, Clinical Sciences, Neurology & Neurosurgery
Abstract

Excerpted proceedings of the Eighth International Workshop on Advances in Electrocorticography (ECoG), which convened October 15-16, 2015 in Chicago, IL, are presented. The workshop series has become the foremost gathering to present current basic and clinical research in subdural brain signal recording and analysis.

Published
2016

18. Proceedings of the Third International Workshop on Advances in Electrocorticography

Author

Ritaccio, Anthony, Beauchamp, Michael, Bosman, Conrado, Brunner, Peter, Chang, Edward, Crone, Nathan, Gunduz, Aysegul, Gupta, Disha, Knight, Robert, Leuthardt, Eric, Litt, Brian, Moran, Daniel, Ojemann, Jeffrey, Parvizi, Josef, Ramsey, Nick, Rieger, Jochem, Viventi, Jonathan, Voytek, Bradley, Williams, Justin, and Schalk, Gerwin

Subjects
Cerebral Cortex, Congresses as Topic, Electroencephalography, Epilepsy, Humans, Brain Mapping, Electrocorticography, Brain-computer interface, High-frequency oscillations, Brain mapping, Seizure detection, Gamma-frequency electroencephalography, Neuroprosthetics, Subdural grid, Clinical Sciences, Neurology & Neurosurgery
Abstract

The Third International Workshop on Advances in Electrocorticography (ECoG) was convened in Washington, DC, on November 10-11, 2011. As in prior meetings, a true multidisciplinary fusion of clinicians, scientists, and engineers from many disciplines gathered to summarize contemporary experiences in brain surface recordings. The proceedings of this meeting serve as evidence of a very robust and transformative field but will yet again require revision to incorporate the advances that the following year will surely bring.

Published
2012

19. Towards an Auditory Attention BCI

Author

Brunner, Peter, Dijkstra, Karen, Coon, William G., Mellinger, Jürgen, Ritaccio, Anthony L., Schalk, Gerwin, Guger, Christoph, editor, Müller-Putz, Gernot, editor, and Allison, Brendan, editor

Published
2015
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20. Clinical characteristics associated with the development of preoperative and postoperative seizures in patients with glioblastoma (P3-1.002)

Author

Boluarte, Sofía Sánchez, primary, Moniz Garcia, Diogo P., additional, Gunasekera, Charlene, additional, Tatum, William, additional, Sirven, Joseph, additional, Freund, Brin, additional, Ritaccio, Anthony, additional, Chaichana, Kaisorn, additional, Quiñones-Hinojosa, Alfredo, additional, and Feyissa, Anteneh, additional

Published
2023
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22. Analog, graded choices in the human brain

Author

Kubanek, Jan, primary, Xie, Tao, additional, Adamek, Markus, additional, Cho, Hohyun, additional, Adamo, Matthew, additional, Ritaccio, Anthony, additional, Willie, Jon, additional, and Brunner, Peter, additional

Published
2023
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31. Acute Brain Activation Patterns of High- Versus Low-Frequency Stimulation of the Anterior Nucleus of the Thalamus During Deep Brain Stimulation for Epilepsy

Author

Middlebrooks, Erik H, primary, Jain, Ayushi, additional, Okromelidze, Lela, additional, Lin, Chen, additional, Westerhold, Erin M, additional, O'Steen, Chad A, additional, Ritaccio, Anthony L, additional, Quiñones-Hinojosa, Alfredo, additional, Tatum, William O, additional, and Grewal, Sanjeet S, additional

Published
2021
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45. Coexistence of childhood absence epilepsy and benign epilepsy with centrotemporal spikes: A case series

Author

Verrotti, Alberto, primary, Casciato, Sara, additional, Spalice, Alberto, additional, Carotenuto, Marco, additional, Striano, Pasquale, additional, Parisi, Pasquale, additional, Zamponi, Nelia, additional, Savasta, Salvatore, additional, Rinaldi, Victoria Elisa, additional, D'Alonzo, Renato, additional, Mecarini, Federico, additional, Ritaccio, Anthony J., additional, and Di Gennaro, Giancarlo, additional

Published
2017
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49. Identifying Selective Auditory Attention to Speech from Electrocorticographic Signals

Author

Gunduz Aysegul, Coon Wiliam, Dijkstra Karen, Farquhar Jason, Schalk Gerwin, Ritaccio Anthony, and Brunner Peter

Subjects
Behavioral Neuroscience, Psychiatry and Mental health, Selective auditory attention, medicine.medical_specialty, Neuropsychology and Physiological Psychology, Neurology, medicine, Audiology, Psychology, Biological Psychiatry
Published
2015

50. Use of Combined Electroencephalography and Tilt Table Testing to Determine Etiology of Loss of Consciousness

Author

Singh, Neeraj, Lynch, Timothy, and Ritaccio, Anthony

Abstract

ABSTRACTTilt table testing is a common noninvasive diagnostic test performed to reproduce and evaluate syncope in a vulnerable patient and subsequently guide therapy. Electroencephalography (EEG) is typically useful for identifying interictal and ictal abnormalities within the context of epilepsy or suspected epilepsy. We report a series of patients who underwent simultaneous tilt table testing with EEG. Diagnostic benefits are not exclusively the verification of EEG correlates secondary to clinical and cardiovascular changes during syncope, but also confirmation of nonphysiological events, including psychogenic nonepileptic seizures and psychogenic pseudosyncope. Fifty tilt table studies were combined with EEG over a six-year period. Seven studies (14%) captured episodes of behavioral unresponsiveness with normal EEG and EKG patterns, diagnostic of psychogenic pseudosyncope. Whereas psychogenic nonepileptic events are well established in the literature, psychogenic pseudosyncope is probably underestimated and rarely evaluated outside of an epilepsy monitoring unit. This novel combined protocol should be considered for any patient with suspected psychogenic unresponsiveness.

Published
2020
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