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17 results on '"Ristenpart, Jasmin"'

1. Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccine

Author

Odak, Ivan, Riemann, Lennart, Sandrock, Inga, Cossmann, Anne, Ramos, Gema Morillas, Hammerschmidt, Swantje I., Ritter, Christiane, Friedrichsen, Michaela, Hassan, Ahmed, Dopfer-Jablonka, Alexandra, Stankov, Metodi V., Weskamm, Leonie M., Addo, Marylyn M., Ravens, Inga, Willenzon, Stefanie, Schimrock, Anja, Ristenpart, Jasmin, Janssen, Anika, Barros-Martins, Joana, Hansen, Gesine, Falk, Christine, Behrens, Georg M.N., and Förster, Reinhold

Published
2024
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2. BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19

Author

Behrens, Georg M. N., Barros-Martins, Joana, Cossmann, Anne, Ramos, Gema Morillas, Stankov, Metodi V., Odak, Ivan, Dopfer-Jablonka, Alexandra, Hetzel, Laura, Köhler, Miriam, Patzer, Gwendolyn, Binz, Christoph, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Krähling, Verena, Bernhardt, Günter, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Hammerschmidt, Swantje I., and Förster, Reinhold

Published
2022
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3. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Author

Barros-Martins, Joana, Hammerschmidt, Swantje I., Cossmann, Anne, Odak, Ivan, Stankov, Metodi V., Morillas Ramos, Gema, Dopfer-Jablonka, Alexandra, Heidemann, Annika, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Bernhardt, Günter, Münch, Jan, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Förster, Reinhold, and Behrens, Georg M. N.

Published
2021
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4. Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination

Author

Stankov, Metodi V, primary, Hoffmann, Markus, additional, Gutierrez Jauregui, Rodrigo, additional, Cossmann, Anne, additional, Morillas Ramos, Gema, additional, Graalmann, Theresa, additional, Winter, Emily Jo, additional, Friedrichsen, Michaela, additional, Ravens, Inga, additional, Ilievska, Tamara, additional, Ristenpart, Jasmin, additional, Schimrock, Anja, additional, Willenzon, Stefanie, additional, Ahrenstorf, Gerrit, additional, Witte, Torsten, additional, Förster, Reinhold, additional, Kempf, Amy, additional, Pöhlmann, Stefan, additional, Hammerschmidt, Swantje I, additional, Dopfer-Jablonka, Alexandra, additional, and Behrens, Georg M N, additional

Published
2024
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5. Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination

Author

Stankov, Metodi V., primary, Hoffmann, Markus, additional, Jauregui, Rodrigo Gutierrez, additional, Cossmann, Anne, additional, Ramos, Gema Morillas, additional, Graalmann, Theresa, additional, Friedrichsen, Michaela, additional, Ravens, Inga, additional, Ilievska, Tamara, additional, Ristenpart, Jasmin, additional, Schimrock, Anja, additional, Willenzon, Stefanie, additional, Ahrenstorf, Gerrit, additional, Witte, Torsten, additional, Förster, Reinhold, additional, Kempf, Amy, additional, Pöhlmann, Stefan, additional, Hammerschmidt, Swantje I., additional, Alexandra, Dopfer-Jablonka, additional, and Behrens, Georg M. N., additional

Published
2023
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9. Omicron infection-associated T- and B-cell immunity in antigen-naive and triple-COVID-19-vaccinated individuals

Author

Barros-Martins, Joana, primary, Hammerschmidt, Swantje I., additional, Morillas Ramos, Gema, additional, Cossmann, Anne, additional, Hetzel, Laura, additional, Odak, Ivan, additional, Köhler, Miriam, additional, Stankov, Metodi V., additional, Ritter, Christiane, additional, Friedrichsen, Michaela, additional, Ravens, Inga, additional, Schimrock, Anja, additional, Ristenpart, Jasmin, additional, Janssen, Anika, additional, Willenzon, Stefanie, additional, Bernhardt, Günter, additional, Lichtinghagen, Ralf, additional, Bošnjak, Berislav, additional, Behrens, Georg M. N., additional, and Förster, Reinhold, additional

Published
2023
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10. The effect of Toll-like receptor agonists on the immunogenicity of MVA-SARS-2-S vaccine after intranasal administration in mice.

Author

Kim Thi Hoang Do, Willenzon, Stefanie, Ristenpart, Jasmin, Janssen, Anika, Volz, Asisa, Sutter, Gerd, Förster, Reinhold, and Bošnjak, Berislav

Subjects
IMMUNOGLOBULINS, SARS-CoV-2, VACCINE immunogenicity, TOLL-like receptors, INTRANASAL administration, LUTEINIZING hormone releasing hormone, VACCINIA
Abstract

Background and aims: Modified Vaccinia virus Ankara (MVA) represents a promising vaccine vector for respiratory administration to induce protective lung immunity including tertiary lymphoid structure, the bronchus-associated lymphoid tissue (BALT). However, MVA expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein (MVA-SARS-2-S) required prime-boost administration to induce high titers of anti-Spike antibodies in serum and bronchoalveolar lavage (BAL). As the addition of adjuvants enables efficient tailoring of the immune responses even to live vaccines, we tested whether Toll-like receptor (TLR)-agonists affect immune responses induced by a single dose of intranasally applied MVA-SARS-2-S. Methods: We intranasally immunized C57BL/6 mice with MVA-SARS-2-S vaccine in the presence of either TLR3 agonist polyinosinic polycytidylic acid [poly(I:C)], TLR4 agonist bacterial lipopolysaccharide (LPS) from Escherichia coli, or TLR9 agonist CpG oligodeoxynucleotide (CpG ODN) 1826. At different timepoints after immunization, we analyzed induced immune responses using flow cytometry, immunofluorescent microscopy, and ELISA. Results: TLR agonists had profound effects on MVA-SARS-2-S-induced immune responses. At day 1 post intranasal application, the TLR4 agonist significantly affected MVA-induced activation of dendritic cells (DCs) within the draining bronchial lymph nodes, increasing the ratio of CD11b+CD86+ to CD103+CD86+ DCs. Nevertheless, the number of Spike-specific CD8+ T cells within the lungs at day 12 after vaccination was increased in mice that received MVA-SARS-2-S coadministered with TLR3 but not TLR4 agonists. TLR9 agonist did neither significantly affect MVA-induced DC activation nor the induction of Spikespecific CD8+ T cells but reduced both number and size of bronchusassociated lymphoid tissue. Surprisingly, the addition of all TLR agonists failed to boost the levels of Spike-specific antibodies in serum and bronchoalveolar lavage. Conclusions: Our study indicates a potential role of TLR-agonists as a tool to modulate immune responses to live vector vaccines. Particularly TLR3 agonists hold a promise to potentiate MVA-induced cellular immune responses. On the other hand, additional research is necessary to identify optimal combinations of agonists that could enhance MVA-induced humoral responses. [ABSTRACT FROM AUTHOR]

Published
2023
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11. BNT162b2 boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19

Author

Behrens, Georg, primary, Barros-Martins, Joana, additional, Cossmann, Anne, additional, Ramos, Gema Morillas, additional, Stankov, Metodi, additional, Odak, Ivan, additional, Dopfer-Jablonka, Alexandra, additional, Hetzel, Laura, additional, Köhler, Miriam, additional, Patzer, Gwendolyn, additional, Binz, Christoph, additional, Ritter, Christiane, additional, Friedrichsen, Michaela, additional, Schultze-Florey, Christian, additional, Ravens, Inga, additional, Willenzon, Stefanie, additional, Bubke, Anja, additional, Ristenpart, Jasmin, additional, Janssen, Anika, additional, Ssebyatika, George, additional, Bernhardt, Günter, additional, Hoffmann, Markus, additional, Pöhlmann, Stefan, additional, Krey, Thomas, additional, Bosnjak, Berislav, additional, Hammerschmidt, Swantje, additional, and Forster, Reinhold, additional

Published
2021
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12. Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents

Author

Bošnjak, Berislav, primary, Odak, Ivan, additional, Barros-Martins, Joana, additional, Sandrock, Inga, additional, Hammerschmidt, Swantje I., additional, Permanyer, Marc, additional, Patzer, Gwendolyn E., additional, Greorgiev, Hristo, additional, Gutierrez Jauregui, Rodrigo, additional, Tscherne, Alina, additional, Schwarz, Jan Hendrik, additional, Kalodimou, Georgia, additional, Ssebyatika, George, additional, Ciurkiewicz, Malgorzata, additional, Willenzon, Stefanie, additional, Bubke, Anja, additional, Ristenpart, Jasmin, additional, Ritter, Christiane, additional, Tuchel, Tamara, additional, Meyer zu Natrup, Christian, additional, Shin, Dai-Lun, additional, Clever, Sabrina, additional, Limpinsel, Leonard, additional, Baumgärtner, Wolfgang, additional, Krey, Thomas, additional, Volz, Asisa, additional, Sutter, Gerd, additional, and Förster, Reinhold, additional

Published
2021
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13. Humoral and cellular immune response against SARS-CoV-2 variants following heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Author

Barros-Martins, Joana, primary, Hammerschmidt, Swantje I., additional, Cossmann, Anne, additional, Odak, Ivan, additional, Stankov, Metodi V., additional, Ramos, Gema Morillas, additional, Dopfer-Jablonka, Alexandra, additional, Heidemann, Annika, additional, Ritter, Christiane, additional, Friedrichsen, Michaela, additional, Schultze-Florey, Christian, additional, Ravens, Inga, additional, Willenzon, Stefanie, additional, Bubke, Anja, additional, Ristenpart, Jasmin, additional, Janssen, Anika, additional, Ssebyatika, George, additional, Bernhardt, Günter, additional, Münch, Jan, additional, Hoffmann, Markus, additional, Pöhlmann, Stefan, additional, Krey, Thomas, additional, Bošnjak, Berislav, additional, Förster, Reinhold, additional, and Behrens, Georg M. N., additional

Published
2021
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14. Humoral and cellular immune response against SARS-CoV-2 variants following heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination.

Author

Behrens, Georg, primary, Barros-Martins, Joana, additional, Hammerschmidt, Swantje, additional, Cossmann, Anne, additional, Odak, Ivan, additional, Stankov, Metodi, additional, Ramos, Gema Morillas, additional, Dopfer-Jablonka, Alexandra, additional, Heidemann, Annika, additional, Ritter, Christiane, additional, Friedrichsen, Michaela, additional, Schultze-Florey, Christian, additional, Ravens, Inga, additional, Bubke, Anja, additional, Ristenpart, Jasmin, additional, Janssen, Anika, additional, Ssebyatika, George, additional, Bernhardt, Günter, additional, Münch, Jan, additional, Hoffmann, Markus, additional, Pöhlmann, Stefan, additional, Krey, Thomas, additional, Bosnjak, Berislav, additional, and Forster, Reinhold, additional

Published
2021
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15. Humoral and cellular immune response against SARS-CoV-2 variants following heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Author

Barros-Martins, Joana, Hammerschmidt, Swantje I, Cossmann, Anne, Odak, Ivan, Stankov, Metodi V, Ramos, Gema Morillas, Dopfer-Jablonka, Alexandra, Heidemann, Annika, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Bernhardt, Günter, Münch, Jan, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Förster, Reinhold, Behrens, Georg M N, and Affiliations

Published
2021
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