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880 results on '"Risteli J"'

1. Rifampicin induces the bone form of alkaline phosphatase in humans

Author

Nabil, H. (Heba), Kummu, O. (Outi), Lehenkari, P. (Petri), Rysä, J. (Jaana), Risteli, J. (Juha), Hakkola, J. (Jukka), and Hukkanen, J. (Janne)

Subjects
musculoskeletal diseases, pregnane X receptor, stomatognathic system, pregnenolone 16α-carbonitrile, musculoskeletal, neural, and ocular physiology, musculoskeletal system, rifampicin, digestive system, alkaline phosphatase, bone
Abstract

Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor that regulates drug metabolism in the liver and intestine. In our clinical trials on healthy volunteers to discover novel metabolic functions of PXR activation, we observed that rifampicin, a well-established ligand for human PXR, 600 mg daily for a week, increased the plasma alkaline phosphatase (ALP) significantly compared with the placebo. Further analysis with lectin affinity electrophoresis revealed that especially the bone form of ALP was elevated. To investigate the mechanism(s) of bone ALP induction, we employed osteoblast lineage differentiated from human primary bone marrow–derived mesenchymal stromal cells. Rifampicin treatment increased ALP activity and mRNA level of bone biomarker genes (ALP, MGP, OPN and OPG). PXR expression was detected in the cells, but the expression was very low compared with the human liver. To further investigate the potential role of PXR in the ALP induction, we treated mice and rats with a rodent PXR ligand pregnenolone 16α-carbonitrile (PCN). However, PCN treatment did not increase plasma ALP activity or bone ALP mRNA expression. In conclusion, rifampicin treatment induces the bone form of ALP in the serum of healthy human volunteers. Further studies are required to establish the mechanism of this novel finding.

Published
2022

6. The Effect of Zoledronic Acid on Serum Biomarkers among Patients with Chronic Low Back Pain and Modic Changes in Lumbar Magnetic Resonance Imaging

Author

Koivisto, K. (Katri), Karppinen, J. (Jaro), Marianne Haapea, M. H. (Marianne Haapea), Järvinen, J. (Jyri), Kyllönen, E. (Eero), Tervonen, O. (Osmo), Niinimäki, J. (Jaakko), Alini, M. (Mauro), Lotz, J. (Jeffrey), Dudli, S. (Stefan), Samartzis, D. (Dino), Risteli, J. (Juha), Majuri, M.-L. (Marja-Leena), Alenius, H. (Harri), Grad, S. (Sibylle), University of Zurich, and Koivisto, Katri

Subjects
Modic change, serum biomarkers, Pain Research, Clinical Trials and Supportive Activities, 10051 Rheumatology Clinic and Institute of Physical Medicine, Evaluation of treatments and therapeutic interventions, 610 Medicine & health, 1308 Clinical Biochemistry, serum biomarkersm magnetic resonance imaging, zoledronic acid, Clinical Research, 6.1 Pharmaceuticals, Musculoskeletal, chronic low back pain, randomized trial, magnetic resonance imaging, Chronic Pain
Abstract

The aim of the current study was to compare changes in serum biomarkers, including inflammatory mediators, signaling molecules, growth factors and markers of bone turnover after a single intravenous infusion of 5 mg zoledronic acid (ZA, a long-acting bisphosphonate; n = 20) or placebo (n = 20) among patients with Modic changes (MC) and chronic low back pain in a randomized controlled design. The MCs were classified into M1, predominating M1, predominating M2, and M2. We measured the serum concentrations of 39 biomarkers at baseline, and one month and one year after treatment. After Benjamini–Hochberg (B–H) correction, we observed significant differences in three biomarkers over one year: Interferon-γ-inducible protein (IP-10) had risen in the ZA group (p = 0.005), whereas alkaline phosphatase (AFOS) and intact procollagen I N-terminal propeptide (iPINP) had significantly decreased in the ZA group, but had not changed in the placebo group (p < 0.001 for both). Change in iPINP correlated with change in the volume of all MC and M1 lesions. ZA downregulated bone turnover markers as expected and, surprisingly, increased the chemokine IP-10 relative to placebo treatment. This adds to our knowledge of the effects of ZA on MC and the biomarkers that signal this process.

Published
2019

11. Radiological and biochemical resolution of nutritional rickets with calcium

Author

Oginni, LM, Sharp, CA, Badru, OS, Risteli, J, Davie, MWJ, and Worsfold, M

Subjects
Rickets -- Diet therapy, Dietary supplements -- Health aspects, Calcium, Dietary -- Health aspects, Family and marriage, Health, Diet therapy, Health aspects
Abstract

Aims: To determine the response to oral calcium in Nigerian children with rickets. Methods: In a teaching hospital in Western Nigeria, 26 children (13 boys, 13 girls, aged 2-5 years) [...]

Published
2003

28. COMMENTARY

Author

Fischer, P R, Oginni, L M, Badru, O S, Sharp, C A, Davie, M W J, Worsfold, M, and Risteli, J

Published
2003

50. Autoimmune antibodies to collagen XIII in myasthenia gravis patients

Author

Tu, H. (Hongmin), Pirskanen‐Matell, R. (Ritva), Heikkinen, A. (Anne), Oikarainen, T. (Tuomo), Risteli, J. (Juha), and Pihlajaniemi, T. (Taina)

Subjects
myasthenia gravis, neuromuscular junction, autoimmune antibody, collagen XIII, autoimmune disease, autoantigen
Abstract

Introduction: Evaluation of the nerve fascicular structure can be useful in diagnosing nerve damage, but it is a very challenging task with 3T MRI because of limited resolution. In this pilot study, we present the feasibility of high‐resolution 7T MRI for examining the nerve fascicular structure. Methods: A 3‐dimensional (3D) gradient‐spoiled sequence was used for imaging peripheral nerves in extremities. Images acquired with different in‐plane resolutions (0.42 × 0.42 mm vs. 0.12 × 0.12 mm), and different main field strengths (7T vs. 3T) were compared. Results: The individual nerve fascicles were identified at 0.12 × 0.12 mm resolution in both field strengths but not at 0.42 × 0.42 mm resolution. The fascicular structure was more sharply depicted in 7T images than in 3T images. Discussion: High‐resolution 3D imaging with 7T MRI demonstrated feasibility for imaging nerve fascicular structures.

Published
2017

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