1. Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis: The MOST Study
- Author
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Fawole, Henrietta O, Riskowski, Jody L, Dell'Isola, Andrea, Steultjens, Martijn P, Nevitt, Michael C, Torner, James C, Lewis, Cora E, Felson, David T, and Chastin, Sebastien FM
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Immunology ,Chronic Pain ,Behavioral and Social Science ,Pain Research ,Aging ,Arthritis ,Clinical Research ,Clinical Trials and Supportive Activities ,Aetiology ,2.4 Surveillance and distribution ,Good Health and Well Being ,Adult ,Aged ,Comorbidity ,Depression ,Fatigue ,Female ,Functional Status ,Gait ,Humans ,Longitudinal Studies ,Male ,Mental Health ,Middle Aged ,Osteoarthritis ,Knee ,Retrospective Studies ,Risk Assessment ,Risk Factors ,United States ,fatigue ,knee osteoarthritis ,longitudinal ,risk factors ,Medical Microbiology ,Clinical sciences - Abstract
AimThe aim of the study was to identify sociodemographic, disease-related, physical and mental health-related determinants of fatigue at 2-year follow-up in individuals with symptomatic knee osteoarthritis (OA).MethodsA longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted to identify predictors of fatigue at 2-year follow-up. Participants self-reported fatigue at baseline for the first time in the MOST cohort and at follow-up using a 0-10 visual analog scale. At baseline, questionnaires on sociodemographics, disease-related symptoms, physical and mental health factors were completed. Data were analyzed using linear regressions with a backwards elimination approach.ResultsOf the 2330 individuals in the MOST cohort at baseline, 576 had symptomatic knee OA and of these, 449 with complete fatigue values at baseline and follow-up were included in this analysis. Minimally important fatigue change (ie, worsening [≥1.13], no change [
- Published
- 2020