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1. Cortical plasticity is associated with blood–brain barrier modulation

Author: Evyatar Swissa, Uri Monsonego, Lynn T Yang, Lior Schori, Lyna Kamintsky, Sheida Mirloo, Itamar Burger, Sarit Uzzan, Rishi Patel, Peter H Sudmant, Ofer Prager, Daniela Kaufer, and Alon Friedman
Subjects: synaptic plasticity, blood–brain barrier, magnetic resonance imaging, caveolae-mediated transcytosis, albumin, transforming growth factor β, Medicine, Science, Biology (General), QH301-705.5
Abstract: Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated leakage of serum albumin to the neuropil have been shown to induce pathological plasticity, neuronal hyper-excitability, and seizures. The effect of neuronal activity on BBB function and whether it plays a role in plasticity in the healthy brain remain unclear. Here we show that neuronal activity induces modulation of microvascular permeability in the healthy brain and that it has a role in local network reorganization. Combining simultaneous electrophysiological recording and vascular imaging with transcriptomic analysis in rats, and functional and BBB-mapping MRI in human subjects, we show that prolonged stimulation of the limb induces a focal increase in BBB permeability in the corresponding somatosensory cortex that is associated with long-term synaptic plasticity. We further show that the increased microvascular permeability depends on neuronal activity and involves caveolae-mediated transcytosis and transforming growth factor β signaling. Our results reveal a role of BBB modulation in cortical plasticity in the healthy brain, highlighting the importance of neurovascular interactions for sensory experience and learning.
Published: 2024
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2. Analysis of a macrophage carbamylated proteome reveals a function in post-translational modification crosstalk

Author: Youngki You, Chia-Feng Tsai, Rishi Patel, Soumyadeep Sarkar, Geremy Clair, Mowei Zhou, Tao Liu, Thomas O. Metz, Chittaranjan Das, and Ernesto S. Nakayasu
Subjects: Lysine carbamylation, Post-translational modification cross-talk, Multi-omics, Cell signaling, Post-translational modification, Medicine, Cytology, QH573-671
Abstract: Abstract Background Lysine carbamylation is a biomarker of rheumatoid arthritis and kidney diseases. However, its cellular function is understudied due to the lack of tools for systematic analysis of this post-translational modification (PTM). Methods We adapted a method to analyze carbamylated peptides by co-affinity purification with acetylated peptides based on the cross-reactivity of anti-acetyllysine antibodies. We also performed immobilized-metal affinity chromatography to enrich for phosphopeptides, which allowed us to obtain multi-PTM information from the same samples. Results By testing the pipeline with RAW 264.7 macrophages treated with bacterial lipopolysaccharide, 7,299, 8,923 and 47,637 acetylated, carbamylated, and phosphorylated peptides were identified, respectively. Our analysis showed that carbamylation occurs on proteins from a variety of functions on sites with similar as well as distinct motifs compared to acetylation. To investigate possible PTM crosstalk, we integrated the carbamylation data with acetylation and phosphorylation data, leading to the identification 1,183 proteins that were modified by all 3 PTMs. Among these proteins, 54 had all 3 PTMs regulated by lipopolysaccharide and were enriched in immune signaling pathways, and in particular, the ubiquitin-proteasome pathway. We found that carbamylation of linear diubiquitin blocks the activity of the anti-inflammatory deubiquitinase OTULIN. Conclusions Overall, our data show that anti-acetyllysine antibodies can be used for effective enrichment of carbamylated peptides. Moreover, carbamylation may play a role in PTM crosstalk with acetylation and phosphorylation, and that it is involved in regulating ubiquitination in vitro. Graphical Abstract Video Abstract
Published: 2023
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3. Cardiovascular Magnetic Resonance (CMR) in Transthyretin Amyloid Cardiomyopathy – a Study of Natural History of Treatment Response

Author: Rishi Patel, BSc, MB, Ana Martinez-Naharro, PhD, Yousuf Razvi, BSc, MB, Adam Ioannou, BSc, MB, Aldostefano Porcari, MD, Liza Chacko, PhD, BSc, MB, James Brown, MB, Daniel Knight, PhD, Tushar Kotecha, PhD, Charlotte Manisty, MD, PhD, James Moon, MD, PhD, Helen Lachmann, MD, Ashutosh Wechalekar, MD, Carol Whelan, MD, Lucia Venneri, MD, PhD, Peter Kellman, PhD, Philip Hawkins, MD, PhD, Julian Gillmore, MD, PhD, and Marianna Fontana, MD, PhD
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2024
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4. Fibrofolliculomas in Birt-Hogg-Dubé syndrome treated with nonfractionated ablative CO2 laser

Author: Rishi Patel, BS, Jesse Wesenberg, BS, and Jennifer Brammeier, DO
Subjects: ablative laser, Birt-Hogg-Dubé, CO2 laser, fibrofolliculoma, fractionally ablative laser, nonfractionated laser, Dermatology, RL1-803
Published: 2023
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5. Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

Author: Anita V. Kumar, Joslyn Mills, Wesley M. Parker, Joshua A. Leitão, Diego I. Rodriguez, Sandrine E. Daigle, Celeste Ng, Rishi Patel, Joseph L. Aguilera, Joseph R. Johnson, Shi Quan Wong, and Louis R. Lapierre
Subjects: Biological sciences, Biochemistry, Science
Abstract: Summary: In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, but their role in longevity is unclear. Here, while determining the regulatory network of the selective autophagy receptor SQST-1/SQSTM1, we uncovered an important role for lipid droplets in proteostasis and longevity. Using genome-wide RNAi screening, we identified several SQST-1 modulators, including lipid droplets-associated and aggregation-prone proteins. Expansion of intestinal lipid droplets by silencing the conserved cytosolic triacylglycerol lipase gene atgl-1/ATGL enhanced autophagy, and extended lifespan. Notably, a substantial amount of ubiquitinated proteins were found on lipid droplets. Reducing lipid droplet levels exacerbated the proteostatic collapse when autophagy or proteasome function was compromised, and significantly reduced the lifespan of long-lived daf-2 animals. Altogether, our study uncovered a key role for lipid droplets in C. elegans as a proteostatic mediator that modulates ubiquitinated protein accumulation, facilitates autophagy, and promotes longevity.
Published: 2023
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6. Abstract Number ‐ 246: Quantification of Hemorrhage Volume for Prediction of Complications of Aneurysmal Subarachnoid Hemorrhage

Author: Jacob M Miller, Matthew T Jones, Rishi Patel, Sebastian Sanchez, and Edgar A Samaniego
Subjects: Neurology. Diseases of the nervous system, RC346-429, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Introduction Aneurysmal subarachnoid hemorrhage (aSAH) can lead to life‐threatening complications such as vasospasm and hydrocephalus. The incidence of these events is influenced by the volume of intracranial hemorrhage. The Fisher score is a subjective adjudication of SAH volume. We developed an objective semi‐automated method to quantify the volume of intracranial hemorrhage. Moreover, we evaluated the association of aSAH volume with vasospasm and hydrocephalus. Methods A custom semi‐automated image segmentation algorithm quantifying aSAH volume was implemented in MATLAB. The volume of hemorrhage was retrospectively measured from non‐contrast brain CT scans with Fisher grade ≥ 2. The algorithm utilized region‐growing and 3D k‐means clustering. Performance was validated against the average of two sets of hemorrhage volumes manually measured. These measurements were obtained from two independent raters who selected regions of interest spanning areas of hemorrhage. The association between blood volume and clinical outcome (hydrocephalus or vasospasm) was evaluated using ROC analysis. Results Fifty‐seven patients were included in this study and 10 patients were used for validation of our method. The ICC between raters for manual measurements of hemorrhage in the validation group was 0.988 (CI: (0.911, 0.997), p < 0.001). Validation of semi‐automated versus manual methods resulted in an ICC of 0.961 (CI: (0.756, 0.991), p < 0.001). Bland‐Altman analysis revealed that the algorithm slightly underestimated blood volume (mean difference = ‐4.11 mL). Hemorrhage volume discriminated for the development of vasospasm (AUC = 0.781) and hydrocephalus (AUC = 0.776). Conclusions Volume of hemorrhage is a key factor that influences the incidence of complications in aSAH. We developed and validated a semi‐automated algorithm for quantifying the volume of aSAH. Vasospasm and hydrocephalus were associated with greater amounts of intracranial blood. Objective measurements of aSAH volume can aid in adjudicating risk of complications among patients with aSAH.
Published: 2023
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7. Differences in Dental Implant Survival between Immediate vs. Delayed Placement: A Systematic Review and Meta-Analysis

Author: Rishi Patel, Cemal Ucer, Simon Wright, and Rabia S. Khan
Subjects: immediate implant placement, survival, dental implants, delayed implant placement, Dentistry, RK1-715
Abstract: Objectives: To compare the impact of immediate and delayed implant placement upon the survival of implants and to investigate the differences in implant survival between immediate and delayed placement in adults. Methods: A search for the relevant literature was performed using the databases of CENTRAL, MEDLINE and Scopus. The studies found were limited to publications between 2014 and 2022, written in the English language, peer-reviewed, and were randomised trials or comparative studies. The quality of the evidence was assessed using the Cochrane Risk of Bias 2.0 and Risk of Bias in Non-randomised Studies—of Interventions appraisal tools and implant survival, and the primary outcome was meta-analysed using RevMan v.5.3. Results: A total of 10 studies were eligible for inclusion, including six randomised controlled trials and four non-randomised comparative studies. Five of the six randomised trials observed a low risk of bias, while the comparative studies had a moderate-to-serious risk of bias. The search strategy resulted in 341 implants placed immediately into fresh extraction sites (332 survived, 97.4%) and 359 implants inserted into delayed sites (350 survived, 97.5%). Conclusion: The meta-analysis demonstrated that there was no significant difference in the implant survival rates between immediately placed implants and implants placed using a delayed timing protocol (risk ratio 0.99; 95% CI 0.96, 1.02, Z = 0.75, p = 0.45). However, the detailed analysis showed that slightly more implant failures happened in the immediate dental implant placement group, with survival rates in some studies ranging between 90 and 95%, while the delayed placement group had survival rates of more than 95%.
Published: 2023
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8. Artificial intelligence-augmented analysis of contemporary procedural, mortality, and cost trends in carcinoid heart disease in a large national cohort with a focus on the 'forgotten pulmonic valve'

Author: Dominique J. Monlezun, Andrew Badalamenti, Awad Javaid, Kostas Marmagkiolis, Kevin Honan, Jin Wan Kim, Rishi Patel, Bindu Akhanti, Dan Halperin, Arvind Dasari, Efstratios Koutroumpakis, Peter Kim, Juan Lopez-Mattei, Syed Wamique Yusuf, Mehmet Cilingiroglu, Mamas A. Mamas, Igor Gregoric, James Yao, Saamir Hassan, and Cezar Iliescu
Subjects: cardio-oncology, carcinoid, valvular disease, artificial intelligence, propensity score, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: BackgroundCarcinoid heart disease is increasingly recognized and challenging to manage due to limited outcomes data. This is the largest known cohort study of valvular pathology, treatment (including pulmonary and tricuspid valve replacements [PVR and TVR]), dispairties, mortality, and cost in patients with malignant carcinoid tumor (MCT).MethodsMachine learning-augmented propensity score-adjusted multivariable regression was conducted for clincal outcomes in the 2016–2018 U.S. National Inpatient Sample (NIS). Regression models were weighted by the complex survey design and adjusted for known confounders and the likelihood of undergoing valvular procedures.ResultsAmong 101,521,656 hospitalizations, 55,910 (0.06%) had MCT. Patients with MCT vs. those without had significantly higher inpatient mortality (2.93 vs. 2.04%, p = 0.002), longer mean length of stay (12.20 vs. 4.62, p < 0.001), and increased mean total cost of stay ($70,252.18 vs. 51,092.01, p < 0.001). There was a step-wise increased rate of TVR and PVR with each subsequent year, with significantly more TV (0.16% vs. 0.01, p < 0.001) and PV (0.03 vs. 0.00, p = 0.040) diagnosed with vs. without MCT for 2016, with comparable trends in 2017 and 2018. There were no significant procedural disparities among patients with MCT for sex, race, income, urban density, or geographic region, except in 2017, when the highest prevalence of PV procedures were performed in the Western North at 50.00% (p = 0.034). In machine learning and propensity score augmented multivariable regression, MCT did not significantly increase the likelihood of TVR or PVR. In sub-group analysis restricted to MCT, neither TVR nor PVR significantly increased mortality, though it did increase cost (respectively, $141,082.30, p = 0.015; $355,356.40, p = 0.012).ConclusionThis analysis reflects a favorable trend in recognizing the need for TVR and PVR in patients with MCT, with associated increased cost but not mortality. Our study also suggests that pulmonic valve pathology is increasingly recognized in MCT as reflected by the upward trend in PVRs. Further research and updated societal guidelines may need to focus on the “forgotten pulmonic valve” to improve outcomes and disparities in this understudied patient population.
Published: 2023
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9. In Situ Preconcentration and Quantification of Cu2+ via Chelating Polymer-Wrapped Multiwalled Carbon Nanotubes

Author: P. U. Ashvin Iresh Fernando, Erik Alberts, Matthew W. Glasscott, Anton Netchaev, Jason D. Ray, Keith Conley, Rishi Patel, Jonathan Fury, David Henderson, Lee C. Moores, and Gilbert K. Kosgei
Subjects: Chemistry, QD1-999
Published: 2021
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10. Red CdSe/ZnS QDs’ Intracellular Trafficking and Its Impact on Yeast Polarization and Actin Filament

Author: Nhi Le, Jonathan Routh, Cameron Kirk, Qihua Wu, Rishi Patel, Chloe Keyes, and Kyoungtae Kim
Subjects: quantum dots, yeast, intracellular trafficking, cytoskeleton, actin filament, polarization, Cytology, QH573-671
Abstract: Quantum dots are nanoparticles (2–10 nm) that emit strong and tunable fluorescence. Quantum dots have been heavily used in high-demand commercialized products, research, and for medical purposes. Emerging concerns have demonstrated the negative impact of quantum dots on living cells; however, the intracellular trafficking of QDs in yeast cells and the effect of this interaction remains unclear. The primary goal of our research is to investigate the trafficking path of red cadmium selenide zinc sulfide quantum dots (CdSe/ZnS QDs) in Saccharomyces cerevisiae and the impact QDs have on yeast cellular dynamics. Using cells with GFP-tagged reference organelle markers and confocal microscopy, we were able to track the internalization of QDs. We found that QDs initially aggregate at the exterior of yeast cells, enter the cell using clathrin-receptor-mediated endocytosis, and distribute at the late Golgi/trans-Golgi network. We also found that the treatment of red CdSe/ZnS QDs resulted in growth rate reduction and loss of polarized growth in yeast cells. Our RNA sequence analysis revealed many altered genes. Particularly, we found an upregulation of DID2, which has previously been associated with cell cycle arrest when overexpressed, and a downregulation of APS2, a gene that codes for a subunit of AP2 protein important for the recruitment of proteins to clathrin-mediated endocytosis vesicle. Furthermore, CdSe/ZnS QDs treatment resulted in a slightly delayed endocytosis and altered the actin dynamics in yeast cells. We found that QDs caused an increased level of F-actin and a significant reduction in profilin protein expression. In addition, there was a significant elevation in the amount of coronin protein expressed, while the level of cofilin was unchanged. Altogether, this suggests that QDs favor the assembly of actin filaments. Overall, this study provides a novel toxicity mechanism of red CdSe/ZnS QDs on yeast actin dynamics and cellular processes, including endocytosis.
Published: 2023
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11. Myocardial Perfusion Imaging After Severe COVID-19 Infection Demonstrates Regional Ischemia Rather Than Global Blood Flow Reduction

Author: George D. Thornton, Abhishek Shetye, Dan S. Knight, Kris Knott, Jessica Artico, Hibba Kurdi, Souhad Yousef, Dimitra Antonakaki, Yousuf Razvi, Liza Chacko, James Brown, Rishi Patel, Kavitha Vimalesvaran, Andreas Seraphim, Rhodri Davies, Hui Xue, Tushar Kotecha, Robert Bell, Charlotte Manisty, Graham D. Cole, James C. Moon, Peter Kellman, Marianna Fontana, and Thomas A. Treibel
Subjects: cardiac MRI, perfusion, COVID-19, microvascular dysfunction, myocardial blood flow, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background: Acute myocardial damage is common in severe COVID-19. Post-mortem studies have implicated microvascular thrombosis, with cardiovascular magnetic resonance (CMR) demonstrating a high prevalence of myocardial infarction and myocarditis-like scar. The microcirculatory sequelae are incompletely characterized. Perfusion CMR can quantify the stress myocardial blood flow (MBF) and identify its association with infarction and myocarditis.Objectives: To determine the impact of the severe hospitalized COVID-19 on global and regional myocardial perfusion in recovered patients.Methods: A case-control study of previously hospitalized, troponin-positive COVID-19 patients was undertaken. The results were compared with a propensity-matched, pre-COVID chest pain cohort (referred for clinical CMR; angiography subsequently demonstrating unobstructed coronary arteries) and 27 healthy volunteers (HV). The analysis used visual assessment for the regional perfusion defects and AI-based segmentation to derive the global and regional stress and rest MBF.Results: Ninety recovered post-COVID patients {median age 64 [interquartile range (IQR) 54–71] years, 83% male, 44% requiring the intensive care unit (ICU)} underwent adenosine-stress perfusion CMR at a median of 61 (IQR 29–146) days post-discharge. The mean left ventricular ejection fraction (LVEF) was 67 ± 10%; 10 (11%) with impaired LVEF. Fifty patients (56%) had late gadolinium enhancement (LGE); 15 (17%) had infarct-pattern, 31 (34%) had non-ischemic, and 4 (4.4%) had mixed pattern LGE. Thirty-two patients (36%) had adenosine-induced regional perfusion defects, 26 out of 32 with at least one segment without prior infarction. The global stress MBF in post-COVID patients was similar to the age-, sex- and co-morbidities of the matched controls (2.53 ± 0.77 vs. 2.52 ± 0.79 ml/g/min, p = 0.10), though lower than HV (3.00 ± 0.76 ml/g/min, p< 0.01).Conclusions: After severe hospitalized COVID-19 infection, patients who attended clinical ischemia testing had little evidence of significant microvascular disease at 2 months post-discharge. The high prevalence of regional inducible ischemia and/or infarction (nearly 40%) may suggest that occult coronary disease is an important putative mechanism for troponin elevation in this cohort. This should be considered hypothesis-generating for future studies which combine ischemia and anatomical assessment.
Published: 2021
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12. Development of Screen-Printable Nafion Dispersion for Electrochemical Sensor

Author: Zun Chen, Rishi Patel, Jacob Berry, Chloe Keyes, Camron Satterfield, Cody Simmons, Alec Neeson, Xi Cao, and Qihua Wu
Subjects: screen-printing, Nafion, electrochemical sensor, cation-exchange membrane, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract: A modified Nafion dispersion for direct screen printing was developed and characterized. Commercial Nafion solution was neutralized to its sodium form and the solvent was replaced by a screen-printing-compatible solvent. The modified Nafion dispersion has optimized rheological properties including shear-thinning behavior, thixotropy, and moderate yield stress. The elemental composition and chemical states of the modified Nafion were characterized by X-ray photoelectron spectroscopy (XPS). The chemical state and composition of the modified Nafion remained the same as those of commercial Nafion. The crystallinity of the cured membranes of both Nafion dispersions was evaluated by X-ray diffraction spectroscopy (XRD). It was found that the modified Nafion has lower crystallinity as compared to the commercial Nafion, and the degree of crystallinity increases with an increase in the curing temperature. The modified material was screen printed onto a commercial sensor as a cation-exchange membrane for the detection of lead Pb(II) in buffer solutions. The sensor showed good linearity in the range of 5 µg/L to 500 µg/L, with a detection limit of 2 µg/L for Pb(II) by square-wave anodic stripping voltammetry. This work demonstrates the possibility of printing Nafion on a large scale in a wide range of fields, such as printed electrochemical sensors.
Published: 2022
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13. Intracellular Trafficking and Distribution of Cd and InP Quantum Dots in HeLa and ML-1 Thyroid Cancer Cells

Author: Min Zhang, Daniel S. Kim, Rishi Patel, Qihua Wu, and Kyoungtae Kim
Subjects: CdSe/ZnS, InP/ZnS, quantum dots, HeLa, ML-1, cancer, Chemistry, QD1-999
Abstract: The study of the interaction of engineered nanoparticles, including quantum dots (QDs), with cellular constituents and the kinetics of their localization and transport, has provided new insights into their biological consequences in cancers and for the development of effective cancer therapies. The present study aims to elucidate the toxicity and intracellular transport kinetics of CdSe/ZnS and InP/ZnS QDs in late-stage ML-1 thyroid cancer using well-tested HeLa as a control. Our XTT (2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) viability assay (Cell Proliferation Kit II) showed that ML-1 cells and non-cancerous mouse fibroblast cells exhibit no viability defect in response to these QDs, whereas HeLa cell viability decreases. These results suggest that HeLa cells are more sensitive to the QDs compared to ML-1 cells. To test the possibility that transporting rates of QDs are different between HeLa and ML-1 cells, we performed a QD subcellular localization assay by determining Pearson’s Coefficient values and found that HeLa cells showed faster QDs transporting towards the lysosome. Consistently, the ICP-OES test showed the uptake of CdSe/ZnS QDs in HeLa cells was significantly higher than in ML-1 cells. Together, we conclude that high levels of toxicity in HeLa are positively correlated with the traffic rate of QDs in the treated cells.
Published: 2022
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14. Use of a cerebral protection device for the laser extraction of a pacemaker lead traversing a patent foramen ovale

Author: James L. Harrison, MA, PhD, MRCP, Rishi Patel, BSc, MRCP, Roy Jogiya, BSc, PhD, MRCP, Simon Redwood, MD, FRCP, FACC, and Christopher A. Rinaldi, MD, FRCP, FHRS
Subjects: Lead extraction, Cerebral protection, Left atrium, Patent foramen ovale, Percutaneous, Laser, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2017
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15. Prior-Free Clock Auctions for Bidders with Interdependent Values.

Author: Vasilis Gkatzelis, Rishi Patel, Emmanouil Pountourakis, and Daniel Schoepflin 0001
Published: 2021
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16. N‐terminal pro‐B‐type natriuretic peptide and h <scp>igh‐sensitivity</scp> troponin T hold diagnostic value in cardiac amyloidosis

Author: Giuseppe Vergaro, Vincenzo Castiglione, Alberto Aimo, Concetta Prontera, Silvia Masotti, Veronica Musetti, Martin Nicol, Alain Cohen Solal, Damien Logeart, Georgios Georgiopoulos, Vladyslav Chubuchny, Alberto Giannoni, Aldo Clerico, Gabriele Buda, Kiara N. Patel, Yousuf Razvi, Rishi Patel, Ashutosh Wechalekar, Helen Lachmann, Philip N. Hawkins, Claudio Passino, Julian Gillmore, Michele Emdin, and Marianna Fontana
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023

17. Cardiovascular magnetic resonance in light-chain amyloidosis to guide treatment

Author: Ana Martinez-Naharro, Rishi Patel, Tushar Kotecha, Nina Karia, Adam Ioannou, Aviva Petrie, Liza A Chacko, Yousuf Razvi, Sriram Ravichandran, James Brown, Steven Law, Cristina Quarta, Shameem Mahmood, Brendan Wisniowski, Silvia Pica, Sajitha Sachchithanantham, Helen J Lachmann, James C Moon, Daniel S Knight, Carol Whelan, Lucia Venneri, Hui Xue, Peter Kellman, Julian D Gillmore, Philip N Hawkins, Ashutosh D Wechalekar, and Marianna Fontana
Subjects: Magnetic Resonance Spectroscopy, Predictive Value of Tests, Myocardium, Humans, Magnetic Resonance Imaging, Cine, Immunoglobulin Light-chain Amyloidosis, Heart, Amyloidosis, Prognosis, Cardiology and Cardiovascular Medicine, Magnetic Resonance Imaging
Abstract: Aims To assess the ability of cardiovascular magnetic resonance (CMR) to (i) measure changes in response to chemotherapy; (ii) assess the correlation between haematological response and changes in extracellular volume (ECV); and (iii) assess the association between changes in ECV and prognosis over and above existing predictors. Methods and results In total, 176 patients with cardiac AL amyloidosis were assessed using serial N-terminal pro-B-type natriuretic peptide (NT-proBNP), echocardiography, free light chains and CMR with T1 and ECV mapping at diagnosis and subsequently 6, 12, and 24 months after starting chemotherapy. Haematological response was graded as complete response (CR), very good partial response (VGPR), partial response (PR), or no response (NR). CMR response was graded by changes in ECV as progression (≥0.05 increase), stable ( Conclusions Cardiac amyloid deposits frequently regress following chemotherapy, but only in patients who achieve CR or VGPR. Changes in ECV predict outcome after adjusting for known predictors.
Published: 2022

18. Effect of drilling and bone substitute on revascularization of an avascular femoral head

Author: Dr. Jignesh Patel, Dr. Yash Mehta, and Dr. Rishi Patel
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022

19. A Cross-Sectional Study to Determine the Association of Corrected QT Interval With Microalbuminuria in Type 2 Diabetes Mellitus

Author: Sonali Sawarthia, Rishi Patel, and Prajakta P Patil
Subjects: General Engineering
Published: 2023

20. Cortical Plasticity is associated with Blood-Brain-Barrier Modulation

Author: Evyatar Swissa, Uri Monsonego, Lynn T. Yang, Lior Schori, Lyna Kamintsky, Sheida Mirloo, Itamar Burger, Sarit Uzzan, Rishi Patel, Peter H Sudmant, Ofer Prager, Daniela Kaufer, and Alon Friedman
Abstract: SummaryBrain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated leakage of serum albumin to the neuropil have been shown to induce pathological plasticity, neuronal hyper-excitability, and seizures. The effect of neuronal activity on BBB function and whether it plays a role in plasticity in the healthy brain remain unclear. Here we show that neuronal activity induces modulation of microvascular permeability in the healthy brain and that it has a role in local network reorganization. Combining simultaneous electrophysiological recording and vascular imaging with transcriptomic analysis in rats, and functional and BBB-mapping MRI in human subjects we show that prolonged stimulation of the limb induces a focal increase in BBB permeability in the corresponding somatosensory cortex that is associated with long-term synaptic plasticity. We further show that the increased microvascular permeability depends on neuronal activity and involves caveolae-mediated transcytosis and transforming growth factor beta signaling. Our results reveal a role of BBB modulation in cortical plasticity in the healthy brain, highlighting the importance of neurovascular interactions for sensory experience and learning.
Published: 2023

21. Tc-99m labelled bone scintigraphy in suspected cardiac amyloidosis

Author: Muhammad Umaid Rauf, Philip N Hawkins, Francesco Cappelli, Federico Perfetto, Mattia Zampieri, Alessia Argiro, Aviva Petrie, Steven Law, Aldostefano Porcari, Yousuf Razvi, Joshua Bomsztyk, Sriram Ravichandran, Adam Ioannou, Rishi Patel, Neasa Starr, David F Hutt, Shameem Mahmood, Brendan Wisniowski, Ana Martinez–Naharro, Lucia Venneri, Carol Whelan, Dorota Roczenio, Janet Gilbertson, Helen J Lachmann, Ashutosh D Wechalekar, Claudio Rapezzi, Matteo Serenelli, Paolo Massa, Angelo Giuseppe Caponetti, Alberto Ponziani, Antonella Accietto, Alessandro Giovannetti, Giulia Saturi, Maurizio Sguazzotti, Christian Gagliardi, Elena Biagini, Simone Longhi, Marianna Fontana, and Julian D Gillmore
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Aims To perform evaluation of widely embraced bone scintigraphy-based non-biopsy diagnostic criteria (NBDC) for ATTR amyloid cardiomyopathy (ATTR-CM) in clinical practice, and to refine serum free light chain (sFLC) ratio cut-offs that reliably exclude monoclonal gammopathy (MG) in chronic kidney disease. Methods and results A multi-national retrospective study of 3354 patients with suspected or histologically proven cardiac amyloidosis (CA) referred to specialist centres from 2015 to 2021; evaluations included radionuclide bone scintigraphy, serum and urine immunofixation, sFLC assay, eGFR measurement and echocardiography. Seventy-nine percent (1636/2080) of patients with Perugini grade 2 or 3 radionuclide scans fulfilled NBDC for ATTR-CM through absence of a serum or urine monoclonal protein on immunofixation together with a sFLC ratio falling within revised cut-offs incorporating eGFR; 403 of these patients had amyloid on biopsy, all of which were ATTR type, and their survival was comparable to non-biopsied ATTR-CM patients (p = 0.10). Grade 0 radionuclide scans were present in 1091 patients, of whom 284 (26%) had CA, confirmed as AL type (AL-CA) in 276 (97%) and as ATTR-CM in only one case with an extremely rare TTR variant. Among 183 patients with grade 1 radionuclide scans, 122 had MG of whom 106 (87%) had AL-CA; 60/61 (98%) without MG had ATTR-CM. Conclusion The NBDC for ATTR-CM are highly specific [97% (95% CI 0.91-0.99)] in clinical setting, and diagnostic performance was further refined here using new cut-offs for sFLC ratio in patients with CKD. A grade 0 radionuclide scan all but excludes ATTR-CM but occurs in most patients with AL-CA. Grade 1 scans in patients with CA and no MG are strongly suggestive of early ATTR-type, but require urgent histologic corroboration.
Published: 2023

22. Safe and rapid development of advanced materials : a research case study for safe development of nanoenabled environmental sensors

Author: Mark Ballentine, Alan Kennedy, Lauren May, Wu-Sheng Shih, Rishi Patel, Vijaya Kavastha, Cynthia Price, Mark Chappell, Kurt Gust, Taylor Rycroft, and Jennifer Laird
Abstract: The enhanced understanding of nanomaterials properties and processing has led to increased use of nanotechnologies, which has also led to greater scrutiny on the commercialization and acquisition of emerging nanoenabled technologies. Caused by knowledge gaps on the unique behaviors, risks, and liabilities of novel engineered nanomaterials, this caution, when not evidence based, slows production and stifles innovation. Reducing the uncertainty surrounding the environmental risks and benefits of nanoenabled technologies, including their resilience in harsh environments, will speed the development and transition of advanced material technologies. In this work, a multifaceted research program generated data and processes to reduce that environmental uncertainty. Specifically, this case study examined printed, nanoenabled environmental sensors and their components to develop toxicological data and parameterize a life-cycle assessment. The study tested the sensors’ resilience in environmental weathering studies that considered both the potential release of the ingredient nanomaterials and the performance of the sensors after exposure to several harsh environmental climates and then created life-cycle inventories to determine environmental impact and reduce cost of research and development. Finally, this case study developed software tools to mitigate the cost of research and provide a framework for presenting toxicology data.
Published: 2023

23. Quantitative Myocardial Perfusion Predicts Outcomes in Patients With Prior Surgical Revascularization

Author: Andreas Seraphim, Benjamin Dowsing, Krishnaraj S. Rathod, Hunain Shiwani, Kush Patel, Kristopher D. Knott, Sameer Zaman, Ieuan Johns, Yousuf Razvi, Rishi Patel, Hui Xue, Daniel A. Jones, Marianna Fontana, Graham Cole, Rakesh Uppal, Rhodri Davies, James C. Moon, Peter Kellman, and Charlotte Manisty
Subjects: Male, Perfusion, Infarction, Ischemia, Predictive Value of Tests, Coronary Circulation, Myocardial Perfusion Imaging, Humans, Female, Coronary Artery Disease, Cardiology and Cardiovascular Medicine, Aged, Retrospective Studies
Abstract: Patients with previous coronary artery bypass graft (CABG) surgery typically have complex coronary disease and remain at high risk of adverse events. Quantitative myocardial perfusion indices predict outcomes in native vessel disease, but their prognostic performance in patients with prior CABG is unknown.In this study, we sought to evaluate whether global stress myocardial blood flow (MBF) and perfusion reserve (MPR) derived from perfusion mapping cardiac magnetic resonance (CMR) independently predict adverse outcomes in patients with prior CABG.This was a retrospective analysis of consecutive patients with prior CABG referred for adenosine stress perfusion CMR. Perfusion mapping was performed in-line with automated quantification of MBF. The primary outcome was a composite of all-cause mortality and major adverse cardiovascular events defined as nonfatal myocardial infarction and unplanned revascularization. Associations were evaluated with the use of Cox proportional hazards models after adjusting for comorbidities and CMR parameters.A total of 341 patients (median age 67 years, 86% male) were included. Over a median follow-up of 638 days (IQR: 367-976 days), 81 patients (24%) reached the primary outcome. Both stress MBF and MPR independently predicted outcomes after adjusting for known prognostic factors (regional ischemia, infarction). The adjusted hazard ratio (HR) for 1 mL/g/min of decrease in stress MBF was 2.56 (95% CI: 1.45-4.35) and for 1 unit of decrease in MPR was 1.61 (95% CI: 1.08-2.38).Global stress MBF and MPR derived from perfusion CMR independently predict adverse outcomes in patients with previous CABG. This effect is independent from the presence of regional ischemia on visual assessment and the extent of previous infarction.
Published: 2022

24. Comparative study of adverse drug reactions of corticosteroids

Author: Dr. Yash Dhamecha, Dr. Rishi Patel, and Dr. Kunal
Published: 2022

25. NT-proBNP and High-Sensitivity Troponin T Hold Diagnostic Value in Cardiac Amyloidosis

Author: Giuseppe, Vergaro, Vincenzo, Castiglione, Alberto, Aimo, Concetta, Prontera, Silvia, Masotti, Veronica, Musetti, Martin, Nicol, Alain, Cohen-Solal, Damien, Logeart, Georgios, Georgiopoulos, Vladyslav, Chubuchny, Alberto, Giannoni, Aldo, Clerico, Gabriele, Buda, Kiara N, Patel, Yousuf, Razvi, Rishi, Patel, Ashutosh, Wechalekar, Helen, Lachmann, Philip N, Hawkins, Claudio, Passino, Julian, Gillmore, Michele, Emdin, and Marianna, Fontana
Abstract: Cardiac amyloidosis (CA) is associated with an elevation of natriuretic peptides and troponins, predicting outcome. Nevertheless, the diagnostic yield of these biomarkers has not been extensively investigated. This study aimed to evaluate the diagnostic performance for CA of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT).Patients with suspected CA (n=1,149) underwent a diagnostic work-up in 3 Centers in Italy, France (n=343, derivation cohort), and United Kingdom (n=806, validation cohort). Biomarker values with either 100% sensitivity or ≥95% specificity were selected as rule-out/rule-in cut-offs, respectively. In the derivation cohort, 227 patients (66%) had CA, and presented with higher NT-proBNP and hs-TnT. NT-proBNP 180 ng/L and hs-TnT 14 ng/L were selected as rule-out cut-offs, and hs-TnT 86 ng/L as rule-in cut-off. NT-proBNP180 ng/L or hs-TnT14 ng/L were found in 7% of patients, ruled out without false negatives. In the validation cohort, 20% of patients (2% false negatives) had NT-proBNP180 ng/L or hs-TnT14 ng/L, and 10% showed both biomarkers below cut-offs (0.5% false negatives). These cut-offs refined CA prediction when added to echocardiographic scores in patients with a hematologic disease or an increased wall thickness. In the validation cohort, the 86 ng/L hs-TnT cut-off ruled in 20% of patients (2% false positives). NT-proBNP and hs-TnT cut-offs retained their rule-out and rule-in performance also in cohorts with CA prevalence of 20%, 10%, 5% and 1% derived from the original cohort through bootstrap analysis.Cardiac biomarkers can refine the diagnostic algorithm in patients with suspected CA. NT-proBNP180 ng/L and hs-TnT14 ng/L reliably exclude the diagnosis, both in the overall population and subgroups referred for either AL-CA or cardiac (pseudo)hypertrophy.
Published: 2022

26. 189 PREVALENCE, DISEASE CHARACTERISTICS AND OUTCOMES OF HEREDITARY TRANSTHYRETIN AMYLOID CARDIOMYOPATHY AMONG ELDERLY INDIVIDUALS

Author: Aldostefano Porcari, Yousuf Razvi, Ambra Masi, Rishi Patel, Adam Ioannou, Muhammad Umaid Rauf, David F Hutt, Dorota Rowczenio, Janet Gilbertson, Ana Martinez-naharro, Lucia Venneri, Carol Whelan, Helen Lachmann, Ashutosh Wechalekar, Candida Cristina Quarta, Marco Merlo, Gianfranco Sinagra, Philip N Hawkins, Marianna Fontana, and Julian D Gillmore
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Aims Transthyretin amyloid cardiomyopathy (ATTR-CM) is often assumed to be associated with wild-type TTR genotype (ATTRwt) in elderly patients (aged ≥70), some of whom are not offered genetic testing. We sought to estimate the prevalence, clinical characteristics and prognostic implications of variant ATTR-CM (ATTRv-CM) among elderly patients. Methods Data from consecutive patients over 70 years of age diagnosed with ATTR-CM at the UK National Amyloidosis Centre between January 2012 and June 2022 were retrospectively evaluated. All patients underwent clinical evaluation, biochemical tests, echocardiography and TTR genotyping. The study outcome was all-cause mortality. Results The study population consisted of 2164 patients with ATTR-CM (median age 79 years at diagnosis, 13.2% females, 80.4% Caucasian). ATTRv-CM was diagnosed in 20% (n=431) of the study population of whom 329 (76.3%) carried V122I, 49 (11.4%) T60A, 18 (4.2%) V30M and 35 (8.1%) other pathogenic TTR variants. During a median (range) follow up of 29 (12-48) months, ATTRv-CM was associated with increased all-cause mortality compared to ATTRwt-CM, with the poorest survival observed in V122I-associated ATTRv-CM (p Conclusions Up to 20% of elderly patients with ATTR-CM have a pathogenic TTR variant. These findings support routine sequencing of the TTR gene in all patients with ATTR-CM regardless of age.
Published: 2022

27. 490 NT-PROBNP AND HIGH-SENSITIVITY TROPONIN T HOLD DIAGNOSTIC VALUE IN CARDIAC AMYLOIDOSIS

Author: Vincenzo Castiglione, Alberto Aimo, Concetta Prontera, Silvia Masotti, Veronica Musetti, Martin Nicol, Alain Cohen-solal, Damien Logeart, Georgios Georgiopoulos, Vladyslav Chubuchny, Alberto Giannoni, Aldo Clerico, Gabriele Buda, Kiara N Patel, Yousuf Razvi, Rishi Patel, Ashutosh Wechalekar, Helen Lachman, Philip N Hawkins, Claudio Passino, Julian Gillmore, Michele Emdin, Marianna Fontana, and Giuseppe Vergaro
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background Cardiac amyloidosis (CA) is associated with an elevation of natriuretic peptides and troponins, predicting outcome. Nevertheless, the diagnostic yield of these biomarkers has not been extensively investigated. Aim To evaluate the diagnostic performance for CA of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-TnT). Methods Patients with suspected CA (n=1,149) underwent a diagnostic work-up in 3 Centers in Italy, France (n=343, derivation cohort), and United Kingdom (n=806, validation cohort). Biomarker values with either 100% sensitivity or ≥95% specificity were selected as rule-out/rule-in cut-offs, respectively. Results In the derivation cohort, 227 patients (66%) had CA, and presented with higher NT-proBNP and hs-TnT. NT-proBNP 180 ng/L and hs-TnT 14 ng/L were selected as rule-out cut-offs, and hs-TnT 86 ng/L as rule-in cut-off. NT-proBNP Conclusions Cardiac biomarkers can refine the diagnostic algorithm in patients with suspected CA. NT-proBNP
Published: 2022

28. Comparison of 99mTc-DPD Scintigraphy, CMR Imaging, and Echocardiography in Patients With V30M-Associated Hereditary Transthyretin Amyloidosis

Author: Henry Somers, Ubaid Tanzim, Aldostefano Porcari, Yousuf Razvi, Tamer Rezk, Rishi Patel, Liza Chacko, Dorota Rowczenio, Janet A. Gilbertson, David F. Hutt, Philip N. Hawkins, Marianna Fontana, Julian D. Gillmore, Somers, Henry, Tanzim, Ubaid, Porcari, Aldostefano, Razvi, Yousuf, Rezk, Tamer, Patel, Rishi, Chacko, Liza, Rowczenio, Dorota, Gilbertson, Janet A., Hutt, David F., Hawkins, Philip N., Fontana, Marianna, and Gillmore, Julian D.
Subjects: Amyloid Neuropathies, Familial, Echocardiography, Prealbumin, Predictive Value of Test, Radiology, Nuclear Medicine and imaging, Radiopharmaceuticals, Radionuclide Imaging, Cardiology and Cardiovascular Medicine, Cardiomyopathie, Human
Abstract: N/A
Published: 2022

29. Comparative study of extramedullary versus intramedullary fixation for unstable Intertrochanteric femur fracture

Author: Lovish Gulbadhar, Hari Menon, Rishi Patel, Nrutik Patel, Viren Atulbhai Umrethiya, and Chandan J Narang
Subjects: medicine.medical_specialty, Dynamic hip screw, Medullary cavity, business.industry, Coxa vara, medicine.disease, law.invention, Surgery, Intramedullary rod, Fixation (surgical), law, Harris Hip Score, medicine, Femur, Malunion, medicine.symptom, business
Abstract: Context: Most frequent fractures of proximal femur are intertrochanteric fractures which involve upper end of femur between both trochanters with or without extending into the upper femoral shaft occuring commonly in geriatric patients. Unstable contribute to about 50%-60% of all intertrochanteric fractures. Aims: Though intertrochanteric fractures unite without surgical intervention, malunion with coxa vara deformity occur with conservative management. The aim of fixation of intertrochanteric fractures is to prevent morbidity and mortality. With this aim of stable surgical reconstruct of intertrochanteric fracture this study was done to evaluate functional, clinical and radiological outcome of unstable intertrochanteric fracture operated with dynamic hip screw with trochanteric stabilization plate (extra meduary fixation) and proximal femoral nailing (intramedullary fixation) and study epidemiology and demographics of intertrochanteric femur fractures in Indian scenario. Settings and Design: Methods and Material: The study was conducted at New Civil Hospital Surat. 50 patients with unstable intertrochanteric femur fractures admitted between february 2018 to march 2019. Conclusions: In this study we found that both-extra-medullary or intramedullary fixation were able to provide good clinical result for unstable Intertrochanteric femur fracture. We conclude that there is statistically significant difference between patients operated with DHS with TSP (Extra medullary implant) and Proximal Femoral Nail (Intramedullary implant) in terms of Blood loss, Mean operative time and functional outcome. Harris hip score in patients treated with PFN had better Harris hip score at final follow up which was statistically significant. All patients in both groups had bony union at final follow up. Blood loss and duration of surgery was significantly less with intramedullary Implant.
Published: 2021

30. Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis

Author: Liza Chacko, Nina Karia, Lucia Venneri, Francesco Bandera, Beatrice Dal Passo, Lodovico Buonamici, Jonathan Lazari, Adam Ioannou, Aldostefano Porcari, Rishi Patel, Yousuf Razvi, James Brown, Daniel Knight, Ana Martinez‐Naharro, Carol Whelan, Candida C. Quarta, Charlotte Manisty, James Moon, Dorota Rowczenio, Janet A. Gilbertson, Helen Lachmann, Ashutosh Wechelakar, Aviva Petrie, William E. Moody, Richard P. Steeds, Luciano Potena, Mattia Riefolo, Ornella Leone, Claudio Rapezzi, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana, Chacko, Liza, Karia, Nina, Venneri, Lucia, Bandera, Francesco, Dal Passo, Beatrice, Buonamici, Lodovico, Lazari, Jonathan, Ioannou, Adam, Porcari, Aldostefano, Patel, Rishi, Razvi, Yousuf, Brown, Jame, Knight, Daniel, Martinez-Naharro, Ana, Whelan, Carol, Quarta, Candida C., Manisty, Charlotte, Moon, Jame, Rowczenio, Dorota, Gilbertson, Janet A., Lachmann, Helen, Wechelakar, Ashutosh, Petrie, Aviva, Moody, William E., Steeds, Richard P., Potena, Luciano, Riefolo, Mattia, Leone, Ornella, Rapezzi, Claudio, Hawkins, Philip N., Gillmore, Julian D., and Fontana, Marianna
Subjects: Heart Failure, Amyloid Neuropathies, Familial, Cardiomyopathy, Echocardiography, Prognosis, Progression, Restrictive, Prognosi, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Humans, Prealbumin, Cardiology and Cardiovascular Medicine, Cardiomyopathies
Abstract: Aims: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly diagnosed disease. Echocardiography is widely utilized, but studies to confirm the value of echocardiography for tracking changes over time are not available. We sought to describe (i) changes in multiple echocardiographic parameters; (ii) differences in rate of progression of three predominant genotypes; and (iii) the ability of changes in echocardiographic parameters to predict prognosis. Methods and results: We prospectively studied 877 ATTR-CM patients attending our centre between 2000 and 2020. Serial echocardiography findings at baseline, 12 months and 24 months were compared with survival. Overall, 565 patients had wild-type ATTR-CM and 312 hereditary ATTR-CM (201 with V122I; 90 with T60A). There was progressive worsening of structural and functional parameters over time, patients with V122I ATTR-CM showing more rapid worsening of left and right ventricular structural and functional parameters compared to both wild-type and T60A ATTR-CM. Among a wide range of echocardiographic analyses, including deformation-based parameters, only worsening in the degree of mitral (MR) and tricuspid regurgitation (TR) at 12- and 24-month assessments was associated with worse prognosis (change at 12 months: MR, hazard ratio 1.43 [95% confidence interval 1.14–1.80], p = 0.002; TR, hazard ratio 1.38 [95% confidence interval 1.10–1.75], p = 0.006). Worsening in MR remained independently associated with poor prognosis after adjusting for known predictors. Conclusion: In ATTR-CM, echocardiographic parameters progressively worsen over time. Patients with V122I ATTR-CM demonstrate the most rapid deterioration. Worsening of MR and TR were the only parameters associated with mortality, MR remaining independent after adjusting for known predictors.
Published: 2022

31. Comparison of Different Technetium-99m-Labeled Bone Tracers for Imaging Cardiac Amyloidosis

Author: Aldostefano Porcari, David F Hutt, Simona F Grigore, Ann-Marie Quigley, Dorota Rowczenio, Janet Gilbertson, Rishi Patel, Yousuf Razvi, Adam Ioannou, Muhammad U Rauf, Ana Martinez-Naharro, Lucia Venneri, Philip N Hawkins, Marianna Fontana, and Julian D Gillmore
Subjects: Epidemiology, Cardiology and Cardiovascular Medicine
Published: 2022

32. Feasibility and efficacy of cryoneurolysis analgesia in robotic-assisted thoracoscopic surgery (CARTS): a pilot study

Author: Michal Hubka, Neil A. Hanson, Jivatesh Tung, Shiwei Han, Joel Sternbach, Rishi Patel, and Taufiq Rajwani
Subjects: Narcotics, medicine.medical_specialty, Pilot Projects, Health Informatics, law.invention, Robotic Surgical Procedures, Randomized controlled trial, law, medicine, Humans, Pain Management, Adverse effect, Cryoneurolysis, Pain, Postoperative, Morphine, business.industry, Thoracoscopy, Chronic pain, medicine.disease, Surgery, Analgesics, Opioid, Regimen, Opioid, Cardiothoracic surgery, Neuralgia, Feasibility Studies, Analgesia, Chronic Pain, business, medicine.drug
Abstract: Opioid therapy has been the mainstay therapy of post-operative pain management in thoracic surgery patients. With the high incidence of chronic pain in thoracic surgery patients and adverse effects of opioids, we examined the safety and efficacy of cryoneurolysis as an adjunct for narcotic-free pain management in robotic-assisted thoracoscopic lobectomies. Ten consecutive patients undergoing robotic-assisted (DaVinci) pulmonary resection and cryoneurolysis were compared to ten patients managed without intraoperative cryoneurolysis. All patients received multimodal pain regimen including paravertebral blocks as per our institutional enhanced recovery pathway. Patients with chronic pain and chronic opioid use were excluded. We compared inpatient and outpatient opioid consumption measured in morphine equivalents (mme), incidence of opioid-free outpatient recovery, and adverse events. The two groups did not differ significantly in terms of baseline demographics. Both inpatient (88.13 vs 26.92 mme) and outpatient (118.5 vs 34.5 mme) use of narcotics were significantly lower in the cryoneurolysis group (p
Published: 2021

33. Five-year clinical performance of two fluoride-releasing giomer resin materials in occlusal restorations

Author: Fusun Ozer, Rishi Patel, Jacqueline Yip, Oksana Yakymiv, Najeed Saleh, and Markus B. Blatz
Subjects: Fluorides, Dental Cavity Lining, Humans, Bisphenol A-Glycidyl Methacrylate, Dental Caries, Dental Restoration, Permanent, General Dentistry, Composite Resins, Follow-Up Studies
Abstract: To evaluate and compare the clinical performance of two nano-hybrid giomer restorative composite materials after 5 years.Forty-four pairs of restorations (total n = 88) of a flowable giomer (Beautifil Flow Plus F00; Shofu Inc., Kyoto, Japan) and a conventional nano-hybrid giomer restorative material (Beautifil II; Shofu Inc.) were placed in Class I cavities after the application of a dentin adhesive (FL-Bond II; Shofu Inc.) and a flowable liner (Beautifil Flow Plus F03; Shofu Inc). After 5 years, 32 pairs of restorations were assessed using the modified United States Public Health Service criteria. Both tested materials were compared using Fisher's exact test and each tested clinical criterion for each material was analyzed separately with respect to different follow-up periods using Friedman's test (a = 0.05).None of the restorations showed complete retention loss, post-operative sensitivity, secondary caries or color change. There were no significant changes to any of the clinical criteria for each material during the 5-year evaluation period (p 0.05) and no significant differences between the two materials in all clinical parameters after 5 years (p 0.05).Five-year clinical performance of both two nano-hybrid giomer restorative materials was comparably acceptable and not significantly different for any of the parameters evaluated.Nano-hybrid giomer-based materials are clinically acceptable for the restoration of occlusal cavities as they demonstrate excellent performance after 5 years.
Published: 2022

34. Angular analysis of the decay B+ → K∗(892)+ μ + μ − in proton-proton collisions at s $$ \sqrt{\mathrm{s}} $$ = 8 TeV

Author: Changwoo Joo, Alessandro Calandri, M. Calderon De La Barca Sanchez, N. Deelen, D. Domínguez Damiani, Diego Beghin, Julie Malcles, Fengwangdong Zhang, Oleg Teryaev, A. Scribano, I. Babounikau, A. Ranieri, Izzeddin Suat Donertas, Livia Soffi, R. B. Garg, Christopher Seez, Matthias Kasemann, Luca Giommi, Cole Lindsey, Ada Solano, Paola Salvini, Yi-ting Duh, Boris Grynyov, B. De La Cruz, Jose F Benitez, Samuel Higginbotham, Salvatore Costa, J. Puerta Pelayo, Indara Suarez, Yong Ban, Florian Beaudette, Devdatta Majumder, Shengquan Tuo, Abhigyan Dasgupta, Daniel Arcaro, Christina Wang, Marek Walczak, Andrea Gelmi, Kinga Anna Wozniak, Stephen Sanders, Maciej Górski, Andrea Malara, Melanie Eich, Anna Macchiolo, Thomas Bergauer, A. Escalante Del Valle, Tariq Aziz, Dave M Newbold, B. Tali, Colin Bernet, Prasant Kumar Rout, J. Mejia Guisao, Ugur Kiminsu, G. P. Van Onsem, Seth Cooper, Luigi Guiducci, Riccardo Paramatti, Andrea Giammanco, Priyanka Kumari, Martti Raidal, Gregory R Snow, Igor Volobouev, Hirak Bandyopadhyay, Marguerite Tonjes, David Mark Raymond, E. O. Olaiya, Christophe Delaere, Özlem Özçelik, Carlos Willmott, R. Del Burgo, Jorge Fraga, Daniel Savoiu, J. Kaspar, Victor Kim, S. May, Semra Turkcapar, Linda Finco, Y-J Lee, Alexander Spiridonov, Marko Dragicevic, Burin Asavapibhop, Xunwu Zuo, I. A. Melzer-Pellmann, Willem Verbeke, Armando Lanaro, Francesca Nessi-Tedaldi, C. Adloff, Yongho Jeong, Karl Gill, Bora Akgun, Awder Mohammed Ahmed, Mingshui Chen, W. A. T. Wan Abdullah, Jamal Rorie, George Karathanasis, Jason Gilmore, Daniel Bloch, Mohamed Rashad Darwish, James Bueghly, Matthew Nguyen, V. Rodríguez Bouza, E. Gurpinar Guler, Pedro G Mercadante, Hans-Christian Kaestli, Ankush Reddy Kanuganti, Marco Paganoni, Don Lincoln, Giuseppe Benedetto Cerati, Y. Choi, Brandon Allen, James D. Olsen, Gyorgy Bencze, Arne Reimers, Xuejun Wang, N. V. Krasnikov, V. Sharma, Andreas Werner Jung, Chandiprasad Kar, G. L. Pinna Angioni, Dimitri Bourilkov, Li Yuan, Caterina Aruta, Flavia Cetorelli, Prabhat Ranjan Pujahari, W. De Boer, Jory Sonneveld, Hafeez R Hoorani, M. A. Mahmoud, Jingzhou Zhao, Yacine Haddad, Q. Wang, Alessandro Cardini, A. García Alonso, Jingyan Li, L. J. Sanchez Rosas, Robert Hirosky, Branislav Ristic, Balashangar Kailasapathy, S. Sanchez Cruz, Lucas Corcodilos, Antonin Kveton, Mauro Menichelli, A. Da Rold, Luca Perniè, Roland Horisberger, M. G. Albrow, Deepak Kumar, J. S. Lange, Manfred Jeitler, Urs Langenegger, Alexander Morton, Pierluigi Paolucci, Wei Zhang, Simona Cometti, Scott Thomas, Ludivine Ceard, Michele Arneodo, Garvita Agarwal, Ka Tung Lau, Demetra Tsiakkouri, Shawn Zaleski, Stavros Mallios, Bisnupriya Sahu, Anadi Canepa, Walaa Elmetenawee, Sophie Wuyckens, Pedro Silva, Regina Demina, Leonid Didukh, S. Luo, Brieuc Francois, Paul Edmund Karchin, Thomas Madlener, Rishi Patel, Y. D. Oh, Andris Skuja, Markus Stoye, Kai Yi, C. Wissing, A. Castaneda Hernandez, Fabrizio Palla, Reyer Band, Dario Menasce, Hyejin Kwon, S. W. Lee, Ivica Puljak, Hans Reithler, Zuhal Seyma Demiroglu, L. Hay, Felipe Ramirez, Matevz Tadel, Berkan Kaynak, J. D. Richman, Yannik Rath, Marek Gruchala, Simranjit Singh Chhibra, Owen Baron, Pritam Kalbhor, Samila Muthumuni, Steve Schnetzer, Saranya Ghosh, Klaas Padeken, Sourabh Dube, Daniele Bonacorsi, Nicholas Haubrich, Aleksandr Iuzhakov, Christopher Rogan, Erika Garutti, L. Borgonovi, Renato Campanini, Qianming Huang, Rosamaria Venditti, Crisostomo Sciacca, Maxim Goncharov, K. Ehataht, Marco Pieri, Gilvan Alves, M. Pelliccioni, Anna Teresa Meneguzzo, Roland Koppenhöfer, Melissa Quinnan, Korbinian Schweiger, Ali Eren Simsek, David Barney, Aleksandra Lelek, Stephanie Beauceron, Vladimir Chekhovsky, Marc Osherson, J. H. Kim, Ben Bylsma, A. Vorobyev, Ulrich Husemann, Alibordi Muhammad, Artur Kalinowski, Roberto Tenchini, Meng Xiao, K. Wong, Yen-Jie Lee, Kevin Black, Louis Lyons, Hugues Lattaud, Anna Kropivnitskaya, Ruslan Chistov, A. Pérez-Calero Yzquierdo, Nicolas Chanon, Christoph Garbers, Muhammad Ansar Iqbal, Ian R Tomalin, David Saltzberg, Mauro Donegà, Igor Bayshev, H. Keller, V. Papadimitriou, P. de Barbaro, Tahereh Sadat Niknejad, M. Bharti, V. Sola, S. Lo Meo, Camelia Mironov, Tongguang Cheng, Stephan E. Maier, Alberto Santoro, H. S. Kim, C. A. Mondragon Herrera, Alexandre Belloni, Andrew Mehta, Jacobo Konigsberg, Bryan Cardwell, Giancarlo Mantovani, Carlo Battilana, Maryam Zeinali, Patrick Jarry, Jeremy Mans, E. E. Boos, Kadri Ozdemir, Mikhail Kirsanov, Kevin Nash, Thea Klaeboe Aarrestad, R. Cousins, S. W. Cho, Andrew Whitbeck, Viktor Veszpremi, Aliaksandr Litomin, A. Manousakis-Katsikakis, Fabio Monti, Vladimir Palichik, Heriberto Castilla-Valdez, Matti J Kortelainen, Sezen Sekmen, Carlos Lourenco, Peter Robmann, Kirika Uchida, Cheng-Chieh Peng, Pallabi Das, Valentina Avati, Anton Petrov, Rudy Ceccarelli, P. Van Mechelen, A. Apyan, Andrew Beretvas, Otto Hindrichs, Grigory Safronov, S. Mitra, Aashaq Shah, I. Gonzalez Caballero, Shabnam Jabeen, S. Lacaprara, Caroline Elisabeth Niniane Niemeyer, Siarhei Shulha, H. Aarup Petersen, Najaf Amin, A. Braghieri, T. Tabarelli de Fatis, Yousen Zhang, Sebastian Wozniewski, Yuri Skovpen, A. Starodumov, Hwi Dong Yoo, A. Di Mattia, Inseok Yoon, Andrew Hart, Demetrios Loukas, Kalpanie Liyanage, Paolo Gunnellini, Erik Butz, S. Tkaczyk, Gage Dezoort, C. Ramón Álvarez, Jan Kieseler, D. E. Pellett, Konstantinos Theofilatos, David Stuart, Benedikt Vormwald, Ilknur Hos, Juliet Ritchie Patterson, Giulia Negro, Alice Mignerey, A. Benecke, Rizki Syarif, Ia Iashvili, Roberto Seidita, Emanuele Usai, T. Aushev, Thomas Reitenspiess, Jordan Nash, Sung Keun Park, Dmitry Philippov, Joao Varela, Leander Litov, Sandor Czellar, J. M. Vizan Garcia, Bugra Bilin, Efe Yazgan, Kati Lassila-Perini, Dongjoon Song, Petra Merkel, De Hua Zhu, Si Xie, Y. Musienko, M. C. Fouz, Robert Stone, Luciano Orsini, Vladimir Cherepanov, K. J. Pena Rodriguez, Hasan Ogul, Simone Calzaferri, J. N. Butler, Paolo Lariccia, Dmitry Sosnov, R. Taus, Luca Pacher, Gouranga Kole, Weinan Si, Robert M Harris, K. Hurtado Anampa, Elliot Hughes, Gurpreet Singh Chahal, Andrew Buccilli, Ivan Atanasov, Ivan Vila, S. Carrillo Moreno, Don Upul Jayasiri Sonnadara, J. S. H. Lee, Claire Shepherd-Themistocleous, Michael Wassmer, Antonis Agapitos, Marc Huwiler, Daniele Spiga, P. Kontaxakis, Manuel Giffels, Jean-Roch Vlimant, Pavel Bunin, Alexei Raspereza, Brajesh C Choudhary, Paul David Luckey, Andrea Trapote, Sébastien Viret, Christoph Heidecker, Nicola Bacchetta, S. Consuegra Rodríguez, K. Osterberg, Ziheng Chen, Maximilian Heindl, Gourab Saha, Valentina Dutta, Sándor Lökös, Giuseppe Barbagli, Salvatore Nuzzo, Philippe Bloch, Martina Vit, Sh. Jain, Laurent Forthomme, Tiziano Camporesi, Lorenzo Bianchini, Brent Stone, Kevin Sung, Louise Skinnari, Gregor Kasieczka, Lukas Lechner, Maksym Titov, Jean-Pierre Merlo, Vito Palladino, Nural Akchurin, Federico Ferri, Douglas Berry, Daniel Denegri, Igor Azhgirey, Frank Golf, Magda Diamantopoulou, A. Buchot Perraguin, Stefanos Leontsinis, Jeremie Alexandre Merlin, Guillaume Bourgatte, Konstanty Sumorok, Fanbo Meng, Caroline Collard, Chayanit Asawatangtrakuldee, J. Alexander, Alexander Savin, M. Finger, G. M. Bilei, David Jonathan Hofman, Joanne Cole, A. K. Virdi, Eija Tuominen, Guo-Ming Chen, Philip Keicher, Vladimir Epshteyn, Angelo Giacomo Zecchinelli, Angela Giraldi, Patrick Connor, Arabella Martelli, Georgy Antchev, Muhammad Ahmad, Rachel Yohay, J. K. Lim, F. Simonetto, Chad Freer, Stefan Piperov, Ioanna Papavergou, David Sperka, Gaelle Boudoul, Wolfgang Waltenberger, A. Baginyan, Vukasin Milosevic, Hartmut Stadie, O. Gonzalez Lopez, J. Wang, Giovanna Selvaggi, Daniel Abercrombie, Natascha Krammer, Suman Bala Beri, Helena Bialkowska, Daniele Pedrini, Mia Liu, Georgios Anagnostou, Melody A. Swartz, Maxwell Chertok, R. Bi, Sridhara Dasu, Emilio Meschi, Alexis Kalogeropoulos, Benedikt Maier, S. J. Qian, Sergio P Ratti, Kelci Mohrman, Sunil Dogra, Olivér Surányi, Nur Zulaiha Jomhari, John Perry Cumalat, Swagata Mukherjee, Shubham Pandey, Wei Shi, O. Rieger, Thomas Klijnsma, A. Moraes, Danek Kotlinski, Jordan Martins, Toni Sculac, Vivian O'Dell, Mikhail Gavrilenko, W. S. Hou, Nadezda Chernyavskaya, Tomas Lindén, N. Van Remortel, Hannu Siikonen, Frank Jensen, A. Melo, Y. Chao, Radia Redjimi, E. M. 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Fonseca De Souza, Simone Pigazzini, Grigory Pivovarov, Ibrahim Soner Zorbakir, Gianny Mestdach, E. Eskut, Natasa Raicevic, David Vannerom, Anne A. Campbell, Sunil Bansal, Giuseppe Iaselli, Vincenzo Mastrapasqua, Georgi Sultanov, Evan Wolfe, David Cutts, Kevin Stenson, C. Mora Herrera, Nicholas Smith, Jean-Charles Fontaine, A. De Cosa, Anton Dimitrov, Achim Stahl, B. Singh, M. Mohammadi Najafabadi, Emil Sørensen Bols, Panja-Riina Luukka, Luciano Di Fiore, Werner Lustermann, Andromachi Tsirou, Roberto Salerno, Scarlet Norberg, Olga Kodolova, Ram Krishna Dewanjee, Bora Isildak, A. Di Pilato, James Strait, Daniel Winterbottom, Thorben Quast, N. Cavallo, Po-Hsun Chen, Stefano Mersi, Mykyta Haranko, Tom A. Williams, Cristina Mantilla, D. Y. Wang, Lalit Mohan Pant, Aaron Dominguez, Felicitas Pauss, Angira Rastogi, Ayse Polatoz, Austin Baty, Paolo Giacomelli, Shin-Shan Yu, Wenxing Fang, Geoffrey Hall, G. N. Kim, Georgios Tsipolitis, Sanjay Padhi, B. Chazin Quero, Dener De Souza Lemos, Panagiotis Kokkas, S. K. Pflitsch, Niels Dupont, Gabriella Pugliese, Zhengcheng Tao, Biagio Rossi, J. M. Hernandez, Edward Laird, Aurore Savoy-Navarro, Luca Mastrolorenzo, Sanchita Bhattacharya, Kevin Lannon, Vieri Candelise, Ted Kolberg, C. Uribe Estrada, Muhammad Shoaib, Claude Charlot, G. Della Ricca, Reddy Pratap Gandrajula, Younes Otarid, Guenakh Mitselmakher, S. Orfanelli, Jordan Damgov, Tobias Pook, Jay Hauser, A. Vilela Pereira, Peter Hansen, Kisung Lee, Francisco Garcia, Basile Vermassen, Jay Mathew Lawhorn, Claude Amsler, P. Klabbers, S. Roy Chowdhury, Andrea Bellora, Laurent Favart, Cristian Pena, Thomas Reis, Christophe Royon, Elizabeth Sexton-Kennedy, Bobae Kim, Matthias Wolf, Paolo Ronchese, Badder Marzocchi, Sanjay Kumar Swain, Marc M Baarmand, Martin Lipinski, Frank Würthwein, Angela Taliercio, Manas Maity, Alexi Mestvirishvili, Ulrich Goerlach, Massimo Casarsa, Steve Nahn, Wren Vetens, Daniele Trocino, Ian Laflotte, C. Mills, Winston Ko, Marco Meschini, Paolo Capiluppi, Frigyes Nemes, James Rohlf, Carlos Avila, Ricardo Eusebi, William Tabb, C. Neu, Thong Nguyen, David Overton, Sang Il Pak, I. De Bruyn, Reza Goldouzian, Mohd Nizam Yusli, Vivan Nguyen, Renato Potenza, Guenter Eckerlin, Armen Tumasyan, Tejinder Virdee, Nicolò Tosi, M. Jones, Camilla Galloni, Paula Eerola, Manoj Sharan, Julia Thom, Finn Rebassoo, M. D. M. Capeans Garrido, C. E. Flores, Neeti Parashar, Klaus Rabbertz, Sebastiano Albergo, Igor Lokhtin, Rui Xiao, Kevin Burkett, Myriam Schönenberger, Zachary Lesko, J. Seixas, Merve Ince, Suyong Choi, Etiennette Auffray, Maurizio Biasini, D. R. Muller, Sinan Sagir, Marta Felcini, Negin Shafiei, Y. Mohammed, Jaana Kristiina Heikkilä, Nikitas Loukas, Mani Tripathi, Rachel Bartek, Marco Peruzzi, Usama Hussain, Owen Rosser Long, M. Csanad, Nicola Amapane, R. Sharma, Andreas Nowack, Olena Karacheban, Koushik Mandal, S. Cooperstein, Michael Reichmann, Anton Babaev, Eric Adams, Dennis Noll, Maria Agnese Ciocci, Maria Florencia Canelli, Fabrizio Ferro, Thomas Ferbel, Stepan Obraztsov, Changgi Huh, Anshul Kapoor, Vipin Bhatnagar, T. Liu, K. F. Chen, L. Malgeri, Kamuran Dilsiz, Seema Bahinipati, Paolo Rumerio, Lorenzo Uplegger, Alexander Fröhlich, Kenneth Bloom, G. Quast, Hannsjoerg Artur Weber, Gordon H. Hanson, Furong Yan, Raffaele Gerosa, Huaqiao Zhang, Alexander Ledovskoy, Vincent J Smith, F. Vazzoler, Shameena Bonomally, Andrey Pozdnyakov, Peter Fackeldey, J. Mijuskovic, R. D. Field, Jack King, Kuntal Mondal, Paraskevas Gianneios, Daniel Pitzl, Joaquin Emilo Siado, R. E. Sosa Ricardo, Oliver Pooth, Andrés Cabrera, Maksat Haytmyradov, Paolo Montagna, Thomas Berger, J. Madhusudanan Sreekala, Othmane Bouhali, Carlos Erice, David Mason, Luigi Moroni, Luca Lista, M. A. Segura Delgado, James G Branson, Samandeep Sharma, He He, Simone Bologna, Georg Steinbrück, David Krofcheck, J. P. Fernández Ramos, S. Gianì, Andrew Evans, Markus Merschmeyer, Eduardo Coelho, Ozlem Kaya, Sevil Salur, Y. Wang, D. Soldi, Barbara Clerbaux, Irene Zoi, Marcello Maggi, Davide Piccolo, Cristina Tuve, S. Sánchez Navas, Jose Chinellato, Richard Cavanaugh, Tomasz Gadek, Marco Rovere, Marco Toliman Lucchini, Mauricio Thiel, Ilya Gorbunov, R. G. Kellogg, Peter Timothy Cox, Alexander Pauls, Torben Lange, Michael Mulhearn, Borislav Pavlov, Vladimir Karjavine, Csaba Hajdu, Jie Xiao, Ilya Kravchenko, Jeroen Hegeman, Maria Teresa Grippo, Anatoli Zarubin, Federica Maria Simone, O. Zenaiev, James Wetzel, S. Seif El Nasr-storey, W. L. Aldá Júnior, Emyr Clement, B. McMaster, Ddc Wickramarathna, C. Fallon, Mario Masciovecchio, Huilin Qu, Dietrich Liko, Mykhailo Dalchenko, Tamás Álmos Vámi, Jingyu Luo, Prafulla Kumar Behera, Riccardo Andrea Manzoni, Christian Veelken, Yu. Andreev, Markus Klute, Joel Goldstein, Luciano Ristori, Milena Misheva, Luigi Calligaris, Kevin Pedro, Silvano Tosi, Ryan Heller, Maxime Guilbaud, Daniel Treille, Kelvin Mei, S. R. Dugad, James Letts, D. De Jesus Damiao, Sebastian Wuchterl, L. Viliani, Seungkyu Ha, Tamas Novak, S. Y. Hoh, F. L. Fabbri, Daniele Fasanella, A. M. Vargas Hernandez, German Martinez, T. Susa, Cristina Botta, Jonathon Langford, Viesturs Veckalns, Dario Bisello, Pascal Paganini, R. Walsh, Jonas Rembser, D. Green, Sema Zahid, Sergei Gleyzer, Ana Ovcharova, Andrea Venturi, M. Khakzad, Rino Castaldi, Brian Dorney, Mariarosaria D'Alfonso, Mario Galanti, Zoltan Szillasi, Jussi Viinikainen, Edoardo Bossini, Andrey Uzunian, E. Asilar, Christopher Palmer, Alice Bean, Balazs Ujvari, Margaret Eminizer, Andrea Piccinelli, S. Belforte, Nabarun Dev, Johan Borg, A. Bermúdez Martínez, Min Suk Kim, Radek Zlebcik, Debabrata Bhowmik, A. Meyer, Conor Henderson, A. Hervé, Prasenjit Mal, Christina Snyder, H. Becerril Gonzalez, Konstantin Matchev, J. J. Hollar, Jean-Marie Brom, Xavier Coubez, Shih-Chang Lee, Fabrice Couderc, Egidio Longo, Francesca Ricci-Tam, Ivan Marchesini, Mohsan Waseem Ather, Anna Stakia, Sébastien Wertz, Salvatore Rappoccio, L. Kreczko, Loukas Gouskos, Matthew P. Johnson, Maksim Azarkin, J. Alcaraz Maestre, Basil Schneider, Xavier Janssen, Nicolo Cartiglia, Shane Breeze, Iban Jose Cabrillo, Michael Krohn, Piotr Zalewski, C. Kleinwort, Xinmei Niu, Dragos Velicanu, Nuno Leonardo, C-E Wulz, Ashutosh Bhardwaj, Lata Panwar, Peter Raics, Peicho Petkov, Erik Brücken, R. Loveless, Dan Brunner, Achille Petrilli, G. Ortona, Sanghyun Ko, V. Makarenko, Sushil Chauhan, Kajari Mazumdar, Nickolas Mccoll, Atul Gurtu, Benjamin Krikler, Junquan Tao, O. Kukral, Abhisek Datta, O. Hlushchenko, Peter Meiring, Manfred Paulini, Jessica Prisciandaro, Genady Gavrilov, Marcus Hohlmann, Byung-Sik Hong, Milan Stojanovic, Mahmod Moussa Abdelkhalek Gadallah, Michael Hildreth, M. S. Meyer, Ugo Gasparini, Veikko Karimäki, Tiziano Rovelli, Sharad Malik, Byeonghak Ko, Sara Fiorendi, Vasken Hagopian, Carlos Florez, G. M. Dallavalle, Bhargav Madhusudan Joshi, Georgios Krintiras, Matteo Presilla, Zeynep Demiragli, Marina Kolosova, Yalcin Guler, Roger Wolf, Lev Dudko, Jeremy Andrea, Tanmay Sarkar, Matthew Joyce, Alberto Ruiz-Jimeno, D. A. Perez Navarro, Ilaria Vai, Nicolas Postiau, Siqi Yuan, Marco Musich, Redwan Habibullah, Hong Ni, Hannes Sakulin, Tilman Rohe, Sara Nabili, Anastasia Karavdina, W. T. Ford, P. J. Fernández Manteca, Luca Guzzi, M. Bluj, Pierluigi Zotto, Robert Bainbridge, T. W. Wang, J. Ripoll Sau, Bożena Boimska, Kerem Cankocak, Andrew Levin, Anton Stepennov, Andrew Loeliger, Andrey Gribushin, Gobinda Majumder, H. Rejeb Sfar, Harrison Prosper, V. Smirnov, Jane Nachtman, Mario Deile, Stephen Robert Wagner, Sergio F Novaes, Samet Lezki, Morgan Lethuillier, Yasar Onel, Filippo Errico, Jean-Louis Faure, Brian Francis, Tamas Ferenc Csorgo, Paolo Checchia, Didar Dobur, Himal Acharya, S. Goy Lopez, Kadir Ocalan, P. Priyanka, David Walter, Amedeo Staiano, Alberto Messineo, John Almond, Austin Ball, S. M. Spanier, Vladimir Blinov, Nathaniel Odell, Ignacio Redondo, J. Berenguer Antequera, Yurii Maravin, Vladimir Gavrilov, Baokai Wang, Z. A. Liu, Jennifer Chu, Viktor Khristenko, M. Lu, Gaël Perrin, Umesh Joshi, H. Sert, Hongbo Liao, Aleko Khukhunaishvili, Daniele Ruini, Stefano Marcellini, Sonaina Undleeb, Michail Bachtis, Alexandra Tews, Bennett Marsh, Sa. Jain, Spandan Mondal, Luc Pape, William Arthur Nash, Vassili Kachanov, Jared Sturdy, Doris Eckstein, Achim Geiser, Batoul Diab, Moritz Guthoff, Marc Weber, Reham Aly, Javier Cuevas, L. Urda Gómez, Fatma Boran, Lara Zygala, Ioannis Papakrivopoulos, Laurent Thomas, Raffaella Tramontano, A. C. Le Bihan, Marcello Abbrescia, Metin Yalvac, Stephan Lammel, Daniel Noonan, D. Valsecchi, Sanjay Kumar, Danila Tlisov, Sourav Chatterjee, M. Alhusseini, R. M. Brown, John Alison, Aliakbar Ebrahimi, Leonardo Cristella, Hannes Jung, Markus Spanring, Mark Saunders, N. De Filippis, Victor Murzin, Q. Li, Arash Jofrehei, Samuel Nathan Webb, Katja Klein, Giovanni Mocellin, Ashish Sharma, A. M. Rossi, Evgueni Vlasov, Qianying Guo, A.-M. Lyon, Kurtis F Johnson, Greg P Heath, Th. Müller, R. Granier de Cassagnac, Alexey Kalinin, Maxime Gouzevitch, Alexander Zhokin, Andrea Beschi, Paul Sheldon, Yuichi Kubota, Andreas Albert, Martijn Mulders, Alexander Dierlamm, A. Rose, S. Kaur, Marius Metzler, A. Bragagnolo, Song-Ming Wang, Kamal Lamichhane, Mary Hadley, Martino Margoni, Daniel Guerrero, Roberto Mulargia, Dylan Gilbert, Michal Szleper, Chia-Ming Kuo, P. Major, Nadia Pastrone, Candan Dozen, Michael Wayne Arenton, J. Duarte, Marek Niedziela, Christoph Schäfer, Alexander Grohsjean, Siddhesh Sawant, S. Meola, Natale Demaria, Xuyang Gao, Shalini Thakur, Navid Rad, N. Turini, Susan Gascon, Gabriel Ramirez-Sanchez, James John Brooke, Cédric Prieels, F. Fiori, Gunther Roland, K. El Morabit, Zheng Wang, Ji Hwan Bhyun, Jeffrey Krupa, Illia Khvastunov, Lev Uvarov, Rajdeep Mohan Chatterjee, Martina Ressegotti, Oleksii Turkot, Michele Selvaggi, O. Behnke, Gulsen Onengut, Viktor Matveev, Lea Caminada, Rong-Shyang Lu, H. Lee, Carlo Civinini, Clemens Lange, K. Sandeep, Santiago Folgueras, George Alverson, Roman Kogler, Satoshi Hasegawa, A. Bodek, Oleksii Toldaiev, Andrew Wildridge, Mark Pesaresi, Claudia Ciocca, S. Shmatov, Kaitlin Salyer, F. Torres Da Silva De Araujo, Markus Seidel, Vineet Kumar, Simon Regnard, Jiajing Mao, Leonid Levchuk, Luca Scodellaro, Christos Roskas, Maria Cepeda, Jorgen D'Hondt, Daniela Schäfer, Tim Ziemons, T. Mitchell, Matthias Komm, Nadeesha Wickramage, Q. Ingram, L. Valencia Palomo, Salvatore Buontempo, Paul Avery, Lisa Benato, L. I. Estevez Banos, Quentin Python, Randy Ruchti, Joe Incandela, Luca Cadamuro, Colin Jessop, Cecilia Elena Gerber, Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., DA ROLD, A., DELLA RICCA, G., Vazzoler, F., and ET AL (the CMS, Collaboration)
Subjects: Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Library science, QC770-798, 01 natural sciences, B physics, Hadron-Hadron scattering (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, 0103 physical sciences, media_common.cataloged_instance, ddc:530, European union, 010306 general physics, Montenegro, China, Nuclear Experiment, media_common, Physics, 010308 nuclear & particles physics, PARTICLE PHYSICS, LARGE HADRON COLLIDER, CMS, Industrial research, Chinese academy of sciences, language.human_language, Physics and Astronomy, language, Physics::Accelerator Physics, Science policy, High Energy Physics::Experiment, Sri lanka, Portuguese
Abstract: BMBWF (Austria); FWF (Austria)Austrian Science Fund (FWF); FNRS (Belgium)Fonds de la Recherche Scientifique - FNRS; FWO (Belgium)FWO; CNPq (Brazil)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ); CAPES (Brazil)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); FAPERJ (Brazil)Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ); FAPERGS (Brazil)Fundacao de Amparo a Ciencia e Tecnologia do Estado do Rio Grande do Sul (FAPERGS); FAPESP (Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); MES (Bulgaria); CERN; CAS (China)Chinese Academy of Sciences; MoST (China)Ministry of Science and Technology, China; NSFC (China)National Natural Science Foundation of China (NSFC); COLCIENCIAS (Colombia)Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias; MSES (Croatia); CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER (Estonia); ERC PUT (Estonia); ERDF (Estonia); Academy of Finland (Finland)Academy of Finland; MEC (Finland); HIP (Finland); CEA (France)French Atomic Energy Commission; CNRS/IN2P3 (France)Centre National de la Recherche Scientifique (CNRS); BMBF (Germany)Federal Ministry of Education & Research (BMBF); DFG (Germany)German Research Foundation (DFG); HGF (Germany); GSRT (Greece)Greek Ministry of Development-GSRT; NKFIA (Hungary); DAE (India)Department of Atomic Energy (DAE); DST (India)Department of Science & Technology (India); IPM (Iran); SFI (Ireland)Science Foundation Ireland; INFN (Italy)Istituto Nazionale di Fisica Nucleare (INFN); MSIP (Republic of Korea); NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE (Malaysia); UM (Malaysia); BUAP (Mexico); CINVESTAV (Mexico); CONACYT (Mexico)Consejo Nacional de Ciencia y Tecnologia (CONACyT); LNS (Mexico); SEP (Mexico); UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MSHE (Poland); NSC (Poland); FCT (Portugal)Portuguese Foundation for Science and TechnologyEuropean Commission; JINR (Dubna); MON (Russia); RosAtom (Russia); RAS (Russia)Russian Academy of Sciences; RFBR (Russia)Russian Foundation for Basic Research (RFBR); NRC KI (Russia); MESTD (Serbia); SEIDI (Spain); CPAN (Spain); PCTI (Spain); FEDER (Spain)European Commission; MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter (Thailand); IPST (Thailand); STAR (Thailand); NSTDA (Thailand); TUBITAK (Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); TAEK (Turkey)Ministry of Energy & Natural Resources - Turkey; NASU (Ukraine); STFC (U.K.)UK Research & Innovation (UKRI)Science & Technology Facilities Council (STFC); DOE (U.S.A.)United States Department of Energy (DOE); NSF (U.S.A.)National Science Foundation (NSF); Marie-Curie program (European Union); European Research Council (European Union)European Research Council (ERC)European Commission [675440, 724704, 752730, 765710]; Horizon 2020 Grant (European Union) [675440, 724704, 752730, 765710]; Leventis Foundation; A.P. Sloan FoundationAlfred P. Sloan Foundation; Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Belgian Federal Science Policy OfficeBelgian Federal Science Policy OfficeEuropean Commission; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium)Fonds de la Recherche Scientifique - FNRS; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium)Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT); F.R.S.-FNRS (Belgium) under the Excellence of Science -EOS -be.h projectFonds de la Recherche Scientifique - FNRS [30820817]; FWO (Belgium) under the Excellence of Science -EOS -be.h projectFWO [30820817]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z191100007219010]; Ministry of Education, Youth and Sports (MEYS) of the Czech RepublicMinistry of Education, Youth & Sports - Czech Republic; Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence StrategyGerman Research Foundation (DFG) [EXC 2121, 390833306]; Lendulet (Momentum) Program of the Hungarian Academy of Sciences (Hungary); Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (Hungary); New National Excellence Program UNKP (Hungary); NKFIA research grants (Hungary) [123842, 123959, 124845, 124850, 125105, 128713, 128786, 129058]; Council of Science and Industrial Research, IndiaCouncil of Scientific & Industrial Research (CSIR) - India; HOMING PLUS program of the Foundation for Polish Science (Poland); European Union, Regional Development Fund (Poland); Mobility Plus program of the Ministry of Science and Higher Education (Poland); National Science Center (Poland)National Science Centre, Poland [Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406]; National Priorities Research Program by Qatar National Research Fund; Ministry of Science and Higher Education (Russia) [02.a03.21.0005]; Tomsk Polytechnic University Competitiveness Enhancement Program; Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu [MDM-2015-0509]; Programa Severo Ochoa del Principado de Asturias; Thalis program - EU-ESF; Aristeia program - EU-ESF; Greek NSRFGreek Ministry of Development-GSRT; Rachadapisek Sompot Fund for Postdoctoral Fellowship (Thailand); Chulalongkorn University (Thailand)Chulalongkorn University; Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); Kavli Foundation; Nvidia Corporation; SuperMicro Corporation; Welch FoundationThe Welch Foundation [C-1845]; Weston Havens Foundation (U.S.A.)
Published: 2021

35. CARDIO-ONCOLOGY PREVALENCE, MORTALITY, COST, AND DISPARITIES FOR TEENAGERS: MACHINE LEARNING ANALYSIS OF 1.27 MILLION HOSPITALIZATIONS

Author: Cezar Iliescu, Sofia Alexandrescu, Dominique Monlezun, Abdelrahman Ali, Leslie Ammabel Ynalvez, Efstratios Koutroumpakis, Nicolas L. Palaskas, Rishi Patel, Awad Javaid, Kevin Honan, Victor Y. Liu, Mehmet Cilingiroglu, Konstantinos Marmagkiolis, and Gloria Iliescu
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023

36. CANCER OUTCOMES, COST, AND DISPARITIES IN CHRONIC TOTAL OCCLUSION: MACHINE LEARNING AND PROPENSITY SCORE ANALYSIS OF 160,875 PERCUTANEOUS CORONARY INTERVENTIONS

Author: Dominique Monlezun, Muhammad T. Bajwa, Jong Kun Park, Jin wan Kim, Rishi Patel, Efstratios Koutroumpakis, Awad Javaid, Kevin Honan, Victor liu, Mehmet Cilingiroglu, Konstantinos Marmagkiolis, Cezar Iliescu, and Salman Atiq Arain
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023

37. CANCER, INSURANCE, AND INCOME DISPARITIES IN TRANSCATHETER MITRAL VALVE REPLACEMENT AND REPAIR: MACHINE LEARNING AND PROPENSITY SCORE ANALYSIS OF 4,827 PROCEDURES

Author: Jong Kun Park, Dominique Monlezun, Abdelrahman Ali, Kevin Honan, Jin wan Kim, Rishi Patel, Awad Javaid, Aamuktha Karla, Nicolas L. Palaskas, Mehmet Cilingiroglu, Abhijeet Dhoble, Konstantinos Marmagkiolis, and Cezar Iliescu
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023

38. CANCER, RACIAL, AND URBAN DISPARITIES IN PERIPHERAL ANGIOGRAPHY: MACHINE LEARNING AUGMENTED NATIONALLY REPRESENTATIVE COST ANALYSIS OF 190,745 HOSPITALIZATIONS

Author: Rishi Patel, Dominique Monlezun, Cezar Iliescu, Salman Atiq Arain, Efstratios Koutroumpakis, Konstantinos Dean Boudoulas, Mehmet Cilingiroglu, Konstantinos Marmagkiolis, Shyam Desai, and Jong Kun Park
Subjects: Cardiology and Cardiovascular Medicine
Published: 2023

39. An Assessment of InP/ZnS as Potential Anti-Cancer Therapy: Quantum Dot Treatment Increases Apoptosis in HeLa Cells

Author: Kyoungtae H. Kim, Qihua Wu, Victoria Davenport, Rishi Patel, and Cullen Horstmann
Subjects: 0301 basic medicine, Programmed cell death, HeLa, Flow cytometry, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, medicine, Viability assay, Cytotoxicity, InP/ZnS, chemistry.chemical_classification, Reactive oxygen species, biology, medicine.diagnostic_test, Chemistry, viability, apoptosis, quantum dot, biology.organism_classification, Molecular biology, 030104 developmental biology, Apoptosis, 030220 oncology & carcinogenesis, transcriptome
Abstract: InP/ZnS quantum dots (QDs) are an emerging option in QD technologies for uses of fluorescent imaging as well as targeted drug and anticancer therapies based on their customizable properties. In this study we explored effects of InP/ZnS when treated with HeLa cervical cancer cells. We employed XTT viability assays, reactive oxygen species (ROS) analysis, and apoptosis analysis to better understand cytotoxicity extents at different concentrations of InP/ZnS. In addition, we compared the transcriptome profile from the QD-treated HeLa cells with that of untreated HeLa cells to identify changes to the transcriptome in response to the QD. RT-qPCR assay was performed to confirm the findings of transcriptome analysis, and the QD mode of action was illustrated. Our study determined both IC50 concentration of 69 &micro, g/mL and MIC concentration of 167 &micro, g/mL of InP/ZnS. It was observed via XTT assay that cell viability was decreased significantly at the MIC. Production of superoxide, measured by ROS assay with flow cytometry, was decreased, whereas levels of nitrogen radicals increased. Using analysis of apoptosis, we found that induced cell death in the QD-treated samples was shown to be significantly increased when compared to untreated cells. We conclude InP/ZnS QD to decrease cell viability by inducing stress via ROS levels, apoptosis induction, and alteration of transcriptome.
Published: 2021

40. Volumetric surveillance of brain aneurysms: Pitfalls of MRA

Author: Ashrita Raghuram, Rishi Patel, Alberto Varon, Ryan Sabotin, Sebastian Sanchez, Colin P Derdeyn, Pascal Jabbour, David M. Hasan, and Edgar A. Samaniego
Abstract: Introduction Untreated brain aneurysms are usually surveilled with serial MR imaging and evaluated with 2D multiplanar measurements. The assessment of aneurysm growth may be more accurate with volumetric analysis. We evaluated the accuracy of a magnetic resonance angiography (MRA) segmentation pipeline for aneurysm volume measurement and surveillance. Methods A pipeline to determine aneurysm volume was developed and tested on two aneurysm phantoms imaged with time-of flight (TOF) MRA and 3D rotational angiography (3DRA). The accuracy of the pipeline was then evaluated by reconstructing 10 aneurysms imaged with contrast enhanced-MRA (CE-MRA) and 3DRA. This calibrated and refined post-processing pipeline was subsequently used to analyse aneurysms from our prospectively acquired database. Volume changes above the threshold of error were considered true volume changes. The accuracy of these measurements was analysed. Results TOF-MRA reconstructions were not as accurate as CE-MRA reconstructions. When compared to 3DRA, CE-MRA underestimated aneurysm volume by 7.8% and did not accurately register the presence of blebs. Eighteen aneurysms (13 saccular and 5 fusiform) were analysed with the optimized 3D volume reconstruction pipeline, with a mean follow-up time of 11 months. Artifact accounted for 10.2% error in volume measurements using serial CE-MRA. When this margin of error was used to assess aneurysms volume in serial imaging with CE-MRA, only two fusiform aneurysms changed in volume. The variations in volume of these two fusiform aneurysms were caused by intra-mural and intrasaccular thrombosis. Conclusions CE-MRA and TOF-MRA 3D volume reconstructions may not register minor morphological changes such as the appearance of blebs. CE-MRA underestimates volume by 7.8% compared to 3DRA. Serial CE-MRA volume measurements had a larger margin of error of approximately 10.2%. MRA-based volumetric measurements may not be appropriate for aneurysm surveillance.
Published: 2022

41. Exploring structural uncertainty and impact of health state utility values on lifetime outcomes in diabetes economic simulation models: Findings from the ninth Mount Hood diabetes quality-of-life challenge

Author: Michelle Tew, Michael Willis, Christian Asseburg, Hayley Bennett, Alan Brennan, Talitha Feenstra, James Gahn, Alastair Gray, Laura Heathcote, William H. Herman, Deanna Isaman, Shihchen Kuo, Mark Lamotte, José Leal, Phil McEwan, Andreas Nilsson, Andrew J. Palmer, Rishi Patel, Daniel Pollard, Mafalda Ramos, Fabian Sailer, Wendelin Schramm, Hui Shao, Lizheng Shi, Lei Si, Harry J. Smolen, Chloe Thomas, An Tran-Duy, Chunting Yang, Wen Ye, Xueting Yu, Ping Zhang, Philip Clarke, and PharmacoTherapy, -Epidemiology and -Economics
Subjects: Glycated Hemoglobin, diabetes, simulation model, Health Policy, Cost-Benefit Analysis, cross-model variability, structural uncertainty, Uncertainty, Models, Economic, Diabetes Mellitus, Type 2, quality-of-life, Quality of Life, Humans, Quality-Adjusted Life Years, economic model
Abstract: Background Structural uncertainty can affect model-based economic simulation estimates and study conclusions. Unfortunately, unlike parameter uncertainty, relatively little is known about its magnitude of impact on life-years (LYs) and quality-adjusted life-years (QALYs) in modeling of diabetes. We leveraged the Mount Hood Diabetes Challenge Network, a biennial conference attended by international diabetes modeling groups, to assess structural uncertainty in simulating QALYs in type 2 diabetes simulation models. Methods Eleven type 2 diabetes simulation modeling groups participated in the 9th Mount Hood Diabetes Challenge. Modeling groups simulated 5 diabetes-related intervention profiles using predefined baseline characteristics and a standard utility value set for diabetes-related complications. LYs and QALYs were reported. Simulations were repeated using lower and upper limits of the 95% confidence intervals of utility inputs. Changes in LYs and QALYs from tested interventions were compared across models. Additional analyses were conducted postchallenge to investigate drivers of cross-model differences. Results Substantial cross-model variability in incremental LYs and QALYs was observed, particularly for HbA1c and body mass index (BMI) intervention profiles. For a 0.5%-point permanent HbA1c reduction, LY gains ranged from 0.050 to 0.750. For a 1-unit permanent BMI reduction, incremental QALYs varied from a small decrease in QALYs (−0.024) to an increase of 0.203. Changes in utility values of health states had a much smaller impact (to the hundredth of a decimal place) on incremental QALYs. Microsimulation models were found to generate a mean of 3.41 more LYs than cohort simulation models ( P = 0.049). Conclusions Variations in utility values contribute to a lesser extent than uncertainty captured as structural uncertainty. These findings reinforce the importance of assessing structural uncertainty thoroughly because the choice of model (or models) can influence study results, which can serve as evidence for resource allocation decisions. Highlights The findings indicate substantial cross-model variability in QALY predictions for a standardized set of simulation scenarios and is considerably larger than within model variability to alternative health state utility values (e.g., lower and upper limits of the 95% confidence intervals of utility inputs). There is a need to understand and assess structural uncertainty, as the choice of model to inform resource allocation decisions can matter more than the choice of health state utility values.
Published: 2022

42. Imaging-Guided Treatment for Cardiac Amyloidosis

Author: Adam Ioannou, Rishi Patel, Julian D. Gillmore, and Marianna Fontana
Subjects: Amyloid Neuropathies, Familial, Cardiac Imaging Techniques, Echocardiography, Humans, Immunoglobulin Light-chain Amyloidosis, Cardiology and Cardiovascular Medicine, Cardiomyopathies
Abstract: Purpose of Review This review will explore the role of cardiac imaging in guiding treatment in the two most commonly encountered subtypes of cardiac amyloidosis (immunoglobulin light-chain amyloidosis [AL] and transthyretin amyloidosis [ATTR]). Recent Findings Advances in multi-parametric cardiac imaging involving a combination of bone scintigraphy, echocardiography and cardiac magnetic resonance imaging have resulted in earlier diagnosis and initiation of treatment, while the evolution of techniques such as longitudinal strain and extracellular volume quantification allow clinicians to track individuals’ response to treatment. Imaging developments have led to a deeper understanding of the disease process and treatment mechanisms, which in combination result in improved patient outcomes. Summary The rapidly expanding treatment regimens for cardiac amyloidosis have led to an even greater reliance on cardiac imaging to help establish an accurate diagnosis, monitor treatment response and aid the adjustment of treatment strategies accordingly.
Published: 2022

43. Image Transformation and CNNs: A Strategy for Encoding Human Locomotor Intent for Autonomous Wearable Robots

Author: Rishi Patel, David F. Fouhey, Ung Hee Lee, Elliott J. Rouse, and Justin Bi
Subjects: Control and Optimization, Computer science, Mechanical Engineering, Biomedical Engineering, Wearable computer, 02 engineering and technology, Convolutional neural network, Computer Science Applications, Human-Computer Interaction, Artificial Intelligence, Control and Systems Engineering, Human–computer interaction, Encoding (memory), Pattern recognition (psychology), 0202 electrical engineering, electronic engineering, information engineering, Robot, 020201 artificial intelligence & image processing, Computer Vision and Pattern Recognition
Abstract: Wearable robots have the potential to improve the lives of countless individuals; however, challenges associated with controlling these systems must be addressed before they can reach their full potential. Modern control strategies for wearable robots are predicated on activity-specific implementations, and testing is usually limited to a single, fixed activity within the laboratory (e.g., level ground walking). To accommodate various activities in real-world scenarios, control strategies must include the ability to safely and seamlessly transition between activity-specific controllers. One potential solution to this challenge is to the infer wearer's intent using pattern recognition of locomotion sensor data. To this end, we developed an intent recognition framework implementing convolutional neural networks with image encoding (i.e. spectrogram) that enables prediction of the upcoming locomotor activity of the wearer's next step. In this letter, we describe our intent recognition system, comprised of a mel-spectrogram and subsequent neural network architecture. In addition, we analyzed the effect of sensor locations and modalities on the recognition system, and compared our proposed system to state-of-the-art locomotor intent recognition strategies. We were able to attain high classification performance (error rate: 1.1%), which was comparable or better than previous systems.
Published: 2020

44. Trends in Published Palliative Care Research: A 15-Year Review

Author: Dheer Patel, Ambereen K. Mehta, Rishi Patel, and Mellar P. Davis
Subjects: Male, Publishing, medicine.medical_specialty, Palliative care, business.industry, Palliative Care, Publications, Specialty, General Medicine, Authorship, United States, Family medicine, Humans, Medicine, Female, Palliative Medicine, business
Abstract: Background: There has been a call for palliative care (PC) published research to support the impact and need for more specialty PC services. Objective: The purpose of this study was to characterize research in PC over a 15-year period in 3 PC journals published in the United States. Design: The authors reviewed every issue of the Journal of Pain and Symptom Management, Journal of Palliative Medicine, and American Journal of Hospice and Palliative Medicine from 2004 through 2018. Studies included were original articles and brief reports. Study type (qualitative, quantitative), author (first and last), gender, and professional degree of the author (first and last) were recorded. Results: A total of 4881 articles were included in this study. The proportion of quantitative papers significantly increased across 3 time points from 63% to 67% to 78%. The proportion of women first authors increased across all 3 time points (54%, 2004-2008; 57%, 2009-2013; 60%, 2014-2018), and the proportion of women last authors increased across all time points (38%, 2004-2008; 44%, 2009-2013; 46%, 2014-2018). More than 40% of authors were physicians. Conclusions: Published PC studies are increasingly quantitative in design. Gender authorship is female dominant for the first authors and increasingly equal across genders for the last authors.
Published: 2020

45. Search for new neutral Higgs bosons through the H → ZA → ℓ + ℓ − b b ¯ $$ \mathrm{H}\to \mathrm{ZA}\to {\ell}^{+}{\ell}^{-}\mathrm{b}\overline{\mathrm{b}} $$ process in pp collisions at s $$ \sqrt{s} $$ = 13 TeV

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Müller, Andre Frankenthal, Jan Krolikowski, Luiz Mundim, Duccio Abbaneo, Guido Tonelli, Cristina Biino, Gabriele Benelli, Patrizia Barria, Filip Moortgat, Konstantinos Kousouris, Arne Reimers, Joshua Bendavid, Nicanor Colino, Jian Sun, Alibordi Muhammad, Evgenii Tarkovskii, Stefanos Leontsinis, Marcin Konecki, Artur Lobanov, Nathaniel Pastika, Ada Solano, Artur Kalinowski, Chayanit Asawatangtrakuldee, Kyle Tos, Ioannis Evangelou, Geonhee Oh, C. K. Mackay, Lisa Borgonovi, L. V. Kardapoltsev, Amitabh Lath, Simon Kudella, Angela Mehta, A. Kasem, C. Martinez Rivero, Giorgio Apollinari, Andrés G Delannoy, Christopher Hill, Ulf Behrens, M. A. Shah, Zeljko Antunovic, Christoph Paus, Charles Mueller, Benjamin Mesic, F. Pandolfi, Teruki Kamon, James Buchanan, Maxim Pieters, A. Di Francesco, Ulrich Heintz, M. Kovac, Bjorn Burkle, B. De La Cruz, Jose F Benitez, Samuel Higginbotham, N. Vanegas Arbelaez, David Petyt, Erhan Gülmez, Kaori Maeshima, Martin Erdmann, Andrew Wisecarver, Tobias Pook, Patricia McBride, Krzysztof Doroba, Dylan Rankin, Andrew Brinkerhoff, Thomas Ferguson, Jose Flix, Didier Contardo, Vladimir Epshteyn, Sung Keun Park, Jay Hauser, A. Vilela Pereira, Dong Ho Moon, Tejinder Virdee, Salvatore Costa, Marco Alexander Harrendorf, Myriam Schönenberger, Fabrice Couderc, Atanu Modak, Marco Cipriani, Peter Elmer, Stephan Albert Wiederkehr, F. M. Stober, AllisonReinsvold Hall, Marcella Diemoz, M. Flechl, Mikhail Dubinin, G. Cucciati, J. Puerta Pelayo, Indara Suarez, Gregor Mittag, Fábio Lúcio Alves, Efe Yazgan, Frank Hartmann, Luciano Orsini, Nicolò Tosi, Camilla Galloni, Seth Conrad Zenz, Manfred Paulini, Jessica Prisciandaro, Fatma Boran, Ajeeta Khatiwada, Maciej Górski, Andrea Malara, A. A. Bin Anuar, Thorben Quast, Damir Lelas, Dajeong Jeon, Giacomo Sguazzoni, Javier Duarte, Adam Elwood, Angelo Giacomo Zecchinelli, Sami Lehti, Adish Vartak, David Bertsche, Valentina Mariani, Markus Stoye, Thomas Bergauer, Michael Planer, Christophe Royon, Elizabeth Sexton-Kennedy, Bobae Kim, Matthias Wolf, Wei Li, Zaixing Mao, Elena Voevodina, Ioannis Papakrivopoulos, Mikhail Danilov, Suat Ozkorucuklu, Wei Xie, Rainer Wallny, V. Drugakov, M. A. Bhat, C. S. Moon, Brian L Winer, Piero Giorgio Verdini, Vincenzo Daponte, M. Vidal Marono, Julia Thom, Finn Rebassoo, Carlos Willmott, R. Del Burgo, F. Mohamad Idris, C. Wissing, A. Castaneda Hernandez, E. Ayala, Wajid Ali Khan, Vladimir Mossolov, Andrew Parker, J. M. Vizan Garcia, Bugra Bilin, Kati Lassila-Perini, Piergiulio Lenzi, A. G. Stahl Leiton, Petra Merkel, Andrej Saibel, De Hua Zhu, Salvatore My, T. A. 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Di Marco, Gaël Touquet, Jeremi Niedziela, Dario Bisello, Pascal Paganini, R. Walsh, Chiara Amendola, A. Di Florio, Jonas Rembser, A. De Wit, Frans Meijers, Stephen Trembath-Reichert, Hessamoddin Kaveh, Edward Scott, William Tabb, Cameron Bravo, and C. Neu
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Large Hadron Collider, Muon, 010308 nuclear & particles physics, Branching fraction, High Energy Physics::Phenomenology, Higgs physics, Electron, Computer Science::Digital Libraries, 01 natural sciences, Bottom quark, Hadron-Hadron scattering (experiments), 0103 physical sciences, Beyond Standard Model, Higgs boson, lcsh:QC770-798, ddc:530, High Energy Physics::Experiment, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, 010306 general physics, Boson, Research data
Abstract: This paper reports on a search for an extension to the scalar sector of the standard model, where a new CP-even (odd) boson decays to a Z boson and a lighter CP-odd (even) boson, and the latter further decays to a b quark pair. The Z boson is reconstructed via its decays to electron or muon pairs. The analysed data were recorded in proton-proton collisions at a center-of-mass energy $$ \sqrt{s} $$ s = 13 TeV, collected by the CMS experiment at the LHC during 2016, corresponding to an integrated luminosity of 35.9 fb−1. Data and predictions from the standard model are in agreement within the uncertainties. Upper limits at 95% confidence level are set on the production cross section times branching fraction, with masses of the new bosons up to 1000 GeV. The results are interpreted in the context of the two-Higgs-doublet model.
Published: 2020

46. Measurement of differential tt¯ production cross sections in the full kinematic range using lepton+jets events from proton-proton collisions at s=13 TeV

Author: Aliaksandr Litomin, Andrew Askew, Aliakbar Ebrahimi, Nicholas Haubrich, Rachel Yohay, Giancarlo Mantovani, J. K. Lim, F. Simonetto, I. Gonzalez Caballero, Shabnam Jabeen, T. Aushev, Parker Gardner, Dmytro Kovalskyi, V. Kutzner, Ram Krishna Dewanjee, Frank Chlebana, L. V. Kardapoltsev, K. Gill, Amitabh Lath, Giovanni Organtini, Paolo Lariccia, A. Baden, Alexandre Zabi, Alessia Saggio, M. Barrio Luna, Cilicia Uzziel Perez, Paolo Spagnolo, P. Gras, Ivan Ovtin, Gyorgy Vesztergombi, Kenneth Long, Frank Jm Geurts, Xuli Yan, B. V. Sathia Narayanan, Claudio Quaranta, Dan Quach, Lindsey Gray, David Petyt, Smarajit Karmakar, Elizabeth Locci, Arnaud Steen, Thomas Reitenspiess, R. F. Von Cube, Riccardo Andrea Manzoni, M. H. Schmitt, Uttiya Sarkar, M. A. Shah, F. Pandolfi, Alicia Calderon, Derek James Cranshaw, Alberto Belloni, Tariq Aziz, David Krofcheck, S. Tkaczyk, David Stuart, Alice Mignerey, A. Benecke, Andrius Juodagalvis, Inna Makarenko, Victor Shang, Fabio Iemmi, Sebastian Wieland, Teruki Kamon, Dmitry Elumakhov, Piet Verwilligen, Guillaume Bourgatte, Malte Backhaus, Evgueni Vlasov, Daniel Savoiu, Y. J. Mao, Chiara Mariotti, Marco Monteno, Boaz Klima, S. Fonseca De Souza, J. F. de Trocóniz, G. G. Hanson, Kenneth Osterberg, Ohannes Kamer Köseyan, Attilio Santocchia, Jean Fay, Fanbo Meng, P. Lenzi, S. V. Afanasiev, Marko Dragicevic, Weinan Si, Mikko Lotti, Georgios Anagnostou, Maxwell Chertok, R. Mulargia, Ulrich Heintz, M. Kovac, Bjorn Burkle, Grigory Pivovarov, S. Slabospitskii, Gianny Mestdach, E. Eskut, Federico Siviero, Pavel Parygin, J. S. Kim, Michael Tytgat, Kaori Maeshima, Martin Erdmann, G. Correia Silva, Seema Bahinipati, Sushrut Karmarkar, Andrew Buccilli, Runyu Bi, Robin Erbacher, Alessio Boletti, Senta Greene, C. Baldenegro Barrera, Chayanit Asawatangtrakuldee, Rogelio Reyes-Almanza, V. 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Fernández Ramos, S. Gianì, Andrew Evans, Fengwangdong Zhang, Markus Merschmeyer, Ozlem Kaya, Sevil Salur, W. L. Aldá Júnior, Daniele Fasanella, B. McMaster, Ddc Wickramarathna, Dietrich Liko, Tapio Lampén, Andre Frankenthal, Mykhailo Dalchenko, Christian Veelken, Yu. Andreev, Markus Klute, Mario Galanti, Joel Goldstein, Milena Misheva, Robert Lee, Silvano Tosi, Norraphat Srimanobhas, Cécile Caillol, Dermot Moran, Ryan Heller, Daniel Treille, Kelvin Mei, S. R. Dugad, D. De Jesus Damiao, Sebastian Wuchterl, Evan Ranken, Tamas Novak, Ibrahim Soner Zorbakir, A. M. Vargas Hernandez, T. Susa, Cristina Botta, Jonathon Langford, Viesturs Veckalns, Dario Bisello, Pascal Paganini, R. Walsh, Jonas Rembser, S. Zhang, D. Soldi, S. Sánchez Navas, Jose Chinellato, Richard Cavanaugh, Ruchi Chudasama, Marco Rovere, Mariana Shopova, Marco Toliman Lucchini, Mauricio Thiel, Ilya Gorbunov, Tobias Pook, Peter Timothy Cox, Torben Lange, Michael Mulhearn, Monika Mittal, Jie Xiao, Jeroen Hegeman, Sang Il Pak, Anatoli Zarubin, Federica Maria Simone, S. Seif El Nasr-storey, Dimitri Bourilkov, Vassili Kachanov, S. W. Cho, Andrew Whitbeck, and Viktor Veszpremi
Subjects: Physics, Nuclear physics, Range (particle radiation), Proton, 010308 nuclear & particles physics, 0103 physical sciences, Kinematics, 010303 astronomy & astrophysics, 01 natural sciences, Differential (mathematics), Lepton
Published: 2021

47. Abstract 12974: Transthyretin Amyloid Cardiomyopathy Associated With the P.V142I Transthyretin Variant is an Inherently Aggressive Form of Transthyretin Amyloid Cardiomyopathy Associated With Significant Functional Impairment and Poor Prognosis

Author: Yousuf Razvi, Sashiananthan Ganesananthan, Liza Chacko, Rishi Patel, Iona Blakeney, Nandita Kaza, Steven Law, Dorota Rowczenio, Janet Gilbertson, David Hutt, Shameem Mahmood, Helen Lachmann, Ashutosh Wechalekar, Brendan Wisniowski, Carol Whelan, Lucia Venneri, Ana Martinez-Naharro, Phillip Hawkins, Marianna Fontana, and Julian D Gillmore
Subjects: Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract: Introduction: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly recognised cause of heart failure. 3-4% of individuals of African descent carry a TTR gene mutation encoding the p.V142I variant, a powerful risk factor for development of variant ATTR-CM; this equates to 1.6 million carriers in the USA. We report deep phenotyping in p.V142I ATTR-CM. Hypothesis: The phenotype of p.V142I ATTR-CM is an aggressive form of ATTR CM. Methods: A retrospective study of 395 patients with p.V142I ATTR-CM from the UK National Amyloidosis Centre. Patients were diagnosed at the Centre through a comprehensive evaluation comprising clinical and functional assessment, echocardiography, radionuclide scintigraphy, histology and biomarker analysis; a subgroup had cardiac magnetic resonance imaging. 395 wild-type ATTR-CM patients matched for independent predictors of prognosis (NAC Disease Stage, age, decade of diagnosis) were used as a comparator group. Results: At time of diagnosis, patients with p.V142I ATTR-CM had significant functional impairment by NYHA classification (NHYA ≥ III; 38.2%) and impairment of echocardiographic parameters; mean LVEF 43%, global longitudinal strain -9.1%, TAPSE 14.2mm, E/E prime 17.4, E/A ratio 2.47 with high frequency of at least moderate mitral (44%) and tricuspid (51%) regurgitation. Uni and multivariate cox regression analysis identified troponin T, TR, LVEF, TAPSE and lower systolic blood pressure as independent predictors of prognosis. Prognostic parameters and 5yr survival (27% v 46%, p Conclusion: p.V142I ATTR-CM has an aggressive phenotype characterised by functional impairment, regurgitant valvular disease and systolic impairment resulting in poor survival. LV systolic impairment, TAPSE, serum troponin and TR were independent predictors of survival, whereas LV wall thickness was not, suggesting as yet unrecognised disease mechanisms.
Published: 2021

48. Comparison of

Author: Henry, Somers, Ubaid, Tanzim, Aldostefano, Porcari, Yousuf, Razvi, Tamer, Rezk, Rishi, Patel, Liza, Chacko, Dorota, Rowczenio, Janet A, Gilbertson, David F, Hutt, Philip N, Hawkins, Marianna, Fontana, and Julian D, Gillmore
Subjects: Amyloid Neuropathies, Familial, Echocardiography, Predictive Value of Tests, Humans, Prealbumin, Radiopharmaceuticals, Cardiomyopathies, Radionuclide Imaging
Published: 2021

49. Measurements of the Electroweak Diboson Production Cross Sections in Proton-Proton Collisions at s=5.02 TeV Using Leptonic Decays

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Choi, Stephen Sanders, Colin Jessop, Daniel Pitzl, Joaquin Emilo Siado, M. León Coello, Paolo Montagna, J. Madhusudanan Sreekala, Othmane Bouhali, Carlos Erice, H. Zhang, David Mason, Luigi Moroni, Luca Lista, Pei-rong Yu, Ketino Kaadze, E. W. Vaandering, M. A. Segura Delgado, Yanwen Liu, He He, Stefanos Leontsinis, Chayanit Asawatangtrakuldee, David Krofcheck, Peter Robmann, A. Baden, M. Barrio Luna, Cilicia Uzziel Perez, B. V. Sathia Narayanan, R. F. Von Cube, K. J. Pena Rodriguez, K. Hurtado Anampa, J. P. Fernández Ramos, R. Kumar Verma, Patrick Connor, Kun Shi, S. Gianì, Sung Keun Park, Andrew Evans, Philip Keicher, Markus Merschmeyer, Ozlem Kaya, Sevil Salur, Joseph Reichert, Changwoo Joo, Alessandro Calandri, M. Calderon De La Barca Sanchez, Maryam Zeinali, Patrick Jarry, A. C. Bundock, P. Martinez Ruiz del Arbol, A. Escalante Del Valle, Ugur Kiminsu, G. P. Van Onsem, Arnab Purohit, Andrey Popov, Martti Raidal, Johann Rauser, C. Wissing, A. 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Richards, Vladimir Palichik, Samuel Bright-Thonney, Duje Giljanovic, Ankush Reddy Kanuganti, Neil Schroeder, Atanu Modak, Peter Elmer, M. K. Jayananda, Marcella Diemoz, Mikhail Dubinin, Dhanush Anil Hangal, Wei Li, Suzanne Rosenzweig, Suat Ozkorucuklu, Wei Xie, Rainer Wallny, Prafulla Saha, Anup Kumar Sikdar, Piero Giorgio Verdini, Giovanni Petrucciani, Gerry Bauer, A.N. Kozyrev, Ivan Amos Cali, Simone Scarfi, Tobias Kramer, Norbert Neumeister, Anterpreet Kaur, Yutaro Iiyama, Mehmet Kaya, S. Ha, Philip Baringer, Enrico Robutti, Tu Thong Tran, George Stephans, Intae Yu, Pritam Palit, A. De Iorio, Pietro Vischia, Dmitry Eliseev, Francisco Matorras, S. Banerjee, Anna Elliott-Peisert, Vuko Brigljevic, Lucia Silvestris, David Taylor, B. Jayatilaka, Josry Metwally, Aran Garcia-Bellido, Debarati Roy, Camille Camen, Furkan Dolek, Franco Ligabue, E. Palencia Cortezon, Kenneth Long, Daniele Pedrini, Benedikt Maier, Andrea Carlo Marini, Alexander Tapper, M. Choi, Vyacheslav Krutelyov, Shirin Chenarani, Deborah Pinna, Jozsef Molnar, Y. Ban, Nicola Minafra, Johannes Schulz, Geonhee Oh, J. De Clercq, Roger Rusack, Marc Dejardin, Tielige Mengke, Irene Dutta, D. Soldi, and S. Sánchez Navas
Subjects: Quantum chromodynamics, Physics, Luminosity (scattering theory), Large Hadron Collider, Muon, Proton, 010308 nuclear & particles physics, Electroweak interaction, General Physics and Astronomy, Electron, 01 natural sciences, 7. Clean energy, Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, Lepton
Abstract: The first measurements of diboson production cross sections in proton-proton interactions at a center-of-mass energy of 5.02 TeV are reported. They are based on data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 302 pb - 1 . Events with two, three, or four charged light leptons (electrons or muons) in the final state are analyzed. The W W , W Z , and Z Z total cross sections are measured as σ W W = 37 . 0 - 5.2 + 5.5 ( stat ) - 2.6 + 2.7 ( syst ) pb , σ W Z = 6. 4 - 2.1 + 2.5 ( stat ) - 0.3 + 0.5 ( syst ) pb , and σ Z Z = 5. 3 - 2.1 + 2.5 ( stat ) - 0.4 + 0.5 ( syst ) pb . All measurements are in good agreement with theoretical calculations at combined next-to-next-to-leading order quantum chromodynamics and next-to-leading order electroweak accuracy.
Published: 2021

50. Combined searches for the production of supersymmetric top quark partners in proton–proton collisions at $$\sqrt{s} = 13\,\text {Te}\text {V} $$

Author: Stephen Sanders, Wesley H Smith, Sergio P Ratti, Parker Gardner, Sunil Dogra, Frank Chlebana, Yihan Liu, Giovanni Organtini, Andris Skuja, Gyorgy Bencze, Arne Reimers, Jaime León Holgado, Colin Bernet, Nadia Pastrone, Moisés León Coello, Ivica Puljak, Dimitri Bourilkov, Andrew Whitbeck, Viktor Veszpremi, Hans Reithler, Ugur Kiminsu, Martti Raidal, Alessia Saggio, Andreas Bernhard Meyer, Paolo Spagnolo, Aliaksandr Litomin, Ben Bylsma, Aliakbar Ebrahimi, Pallabi Das, Min Sang Ryu, Burin Asavapibhop, Xunwu Zuo, Roberto Tenchini, Meng Xiao, Zhengyun You, Andrew Mehta, Jacobo Konigsberg, Shabnam Jabeen, Stephane Perries, Costas Foudas, Antonio Vagnerini, Andreas Psallidas, Douglas Wright, Giles Strong, Tommaso Diotalevi, Panagiotis Katsoulis, Serguei Afanasiev, Young Do Oh, Bryan Cardwell, Christopher Cosby, Stephen Mrenna, Konstantinos Manolopoulos, Michael Gordon, Claudio Quaranta, Lindsey Gray, James Bueghly, Matthew Nguyen, Devdatta Majumder, Anna Zacharopoulou, David Hamilton, Alessandro Da Rold, Derek James Cranshaw, Alberto Belloni, Malte Backhaus, Gian Mario Bilei, Tatyana Dimova, Thomas Reitenspiess, Dmytro Kovalskyi, Jose M Hernandez, Hyejin Kwon, Gyorgy Vesztergombi, Luca Malgeri, J. Davis, Flavia Cetorelli, Henri Petrow, Frank Jm Geurts, Xuli Yan, Katherine Victoria Ellis, Marco Zanetti, Pedro G Mercadante, Tae Jeong Kim, Siarhei Shulha, Marco Cipriani, Emmanouil Vourliotis, John Hakala, Michael Murray, Jonathan Wilson, Jakob Salfeld-Nebgen, Louis Moureaux, Sebastian Wiedenbeck, Lukas Lechner, Robert M Harris, Nicholas Wardle, Tao Huang, Nazar Bartosik, Enrique Palencia Cortezon, Dominique Gigi, Raffaello D'Alessandro, Slawek Tkaczyk, Jingzhou Zhao, Max Vanden Bemden, Marvin Johnson, Hans-Christian Kaestli, Branislav Ristic, Balashangar Kailasapathy, C. A. Carrillo Montoya, Jeremy Mans, Silvia Goy Lopez, Zoltan Gecse, Arnaud Steen, H. S. Chen, Davide Zuolo, Giacomo Sguazzoni, Alan Campbell, Kathryn Coldham, Boaz Klima, Pavel Parygin, Richard G Kellogg, Antonio Rossi, Michael Tytgat, David Lange, Robin Erbacher, Edy Ayala, Miranda Bryson, Pierluigi Bortignon, Guido Tonelli, Yasser Maghrbi, Zeljko Antunovic, Paolo Gunnellini, Y. Kang, Juliet Ritchie Patterson, Pedro Silva, Sridhara Dasu, Emilio Meschi, Shaun Hogan, Attilio Santocchia, Meng Lu, Jean Fay, Dennis Roy, Igor Dremin, Raman Khurana, Hanwen Wang, Raghunath Pradhan, Andrei Sobol, Gabriella Pasztor, Sebastian Templ, Lizardo Valencia Palomo, Vladimir Cherepanov, Hasan Ogul, Aram Apyan, Daniel Alejandro Perez Navarro, Don Upul Jayasiri Sonnadara, Claudia-Elisabeth Wulz, Matteo Maria Defranchis, Christoph Paus, John Perry Cumalat, Swagata Mukherjee, Valentin Sulimov, Philip H Butler, Prolay Mal, Toni Sculac, Todor Ivanov, Hugo Becerril Gonzalez, Inkyu Park, Aliya Nigamova, Alexandros Attikis, Jordan Martins, Diego Alejandro Sanz Becerra, Alessandro Rossi, Abbas Hassani, Matthias Schröder, Oliver Gutsche, Joachim Baechler, Zhenan Liu, Peter Paulitsch, Gage Dezoort, Andreas Pfeiffer, Alessandra Cappati, Jeffrey Richman, Gilvan Alves, Daniele Bonacorsi, Nicholas Haubrich, Jan Kaspar, Senta Greene, Sergey Shmatov, Dylan Teague, Tamer Elkafrawy, Hyunyong Kim, Konstantinos Theofilatos, Bradley Cox, Kirill Skovpen, Oz Amram, Vladislav Borshch, Hyunchul Kim, Tom Cornelis, Wolfgang Waltenberger, Pierluigi Paolucci, Daniele Fasanella, Sandor Czellar, Shivali Malhotra, Gunter Quast, Tanmay Mudholkar, Ennio Monteil, Aldo Penzo, Jordan Nash, Regina Demina, Joao Varela, Bipen Singh, Leander Litov, Kyong Sei Lee, Muhammad Gul, Jean-Pierre Merlo, Nicolas Tonon, Artur Gottmann, Aimilios Ioannou, Manuel Giffels, Arkadios Manousakis-Katsikakis, Gurpreet Singh Chahal, Sushrut Karmarkar, Andrew Buccilli, Arun Kumar, Marc Huwiler, Daniele Spiga, Matteo Cremonesi, Jaehoon Lim, Nitish Dhingra, Alejandro Sanchez, Weijie Jin, Sourabh Dube, Sung Keun Park, Stephen Butalla, You-ying Li, Samuel Bein, Daniel Spitzbart, Nils Faltermann, Duong Nguyen, Vladyslav Danilov, Dirk Krücker, Gui Nyun Kim, Christopher Madrid, Neil Schroeder, Roberto Rossin, Siew Yan Hoh, Alexander Ershov, Emine Gurpinar Guler, Gianluca Cerminara, Jesus Manuel Vizan Garcia, Ali Awais, Zuhal Seyma Demiroglu, Felipe Ramirez, Piergiulio Lenzi, Arthur Moraes, Sándor Lökös, Kithsiri Malagalage, Georg Auzinger, Rafael Eduardo Sosa Ricardo, Jindrich Lidrych, Harvey B Newman, Jeffrey Berryhill, Berkan Kaynak, Marc Osherson, Alibordi Muhammad, Artur Kalinowski, Karla Josefina Pena Rodriguez, Clément Grimault, Paul Kyberd, Sema Zahid, Dominic Stafford, Franz Glessgen, Korbinian Schweiger, Maciej Górski, Anna Kropivnitskaya, Muhammad Imran Malik Awan, Natale Demaria, Angelo Giacomo Zecchinelli, Gustavo Gil Da Silveira, Maria Rosaria Di Domenico, Angela Giraldi, Joanne Cole, Eija Tuominen, Luigi Fiore, S. Rudrabhatla, Bugra Bilin, Kati Lassila-Perini, Abhishek Das, Petra Merkel, Sergei Gleyzer, Allison Reinsvold Hall, Guo-Ming Chen, Mohammad Hassan Hassanshahi, Arabella Martelli, Soureek Mitra, Muhammad Ahmad, Claudia Pistone, Yongbin Feng, Wolfgang Adam, De Hua Zhu, Nabin Poudyal, Ralf Ulrich, Juliette Alimena, Atanu Modak, Peter Elmer, Gilson Correia Silva, Andreas Hinzmann, Marcin Konecki, Artur Lobanov, Nathaniel Pastika, Antonio Delgado Peris, Salvatore My, A. H. Merrit, Kaur Sandeep, Ioannis Evangelou, Paul Asmuss, Dennis Schwarz, Ekaterina Kuznetsova, Lisa Borgonovi, Lloyd Stanley Durkin, Hevjin Yarar, Diwakar Vats, Kelci Mohrman, Si Xie, Tahereh Sadat Niknejad, Konstantinos Vellidis, David Jonathan Hofman, Yi Wang, Paul Dauncey, Ruslan Chistov, Kadri Ozdemir, Chosila Sutantawibul, Mikhail Dubinin, Andrea Venturi, Isidro Gonzalez Caballero, Geetanjali Chaudhary, Roberval Walsh, Piet Verwilligen, S. K. Kim, Vincenzo Innocente, Mattia Lizzo, Jaebeom Park, Ricardo Lopez-Fernandez, Giovanna Selvaggi, Pierre Van Hove, Stefan Spanier, Ibrahim Soner Zorbakir, Tirso Alejandro Gómez Espinosa, Heriberto Castilla-Valdez, Joseph Lynn Dulemba, Marc Dünser, James Dolen, Robert Stone, Simone Calzaferri, Shuai Yang, Wei Li, Damir Lelas, Suzanne Rosenzweig, Suman Bala Beri, Alberto Santoro, Dajeong Jeon, Federico Vazzoler, Subash Chandra Behera, Nur Zulaiha Jomhari, Freya Blekman, Leszek Grzanka, Lucia Silvestris, Shubham Pandey, Wei Shi, Andrea Castro, Brian L Winer, Mehmet Özgür Sahin, Donato Creanza, Vivian O'Dell, Ioannis Papadopoulos, Efstathios Paganis, David Seith, Charlotte Cooke, David Vannerom, Catherine Vander Velde, Umesh Joshi, Javier Duarte, Daniel Tapia Takaki, Maryam Zeinali, Patrick Jarry, Anna Benecke, Suvankar Roy Chowdhury, Alexey Vorobyev, Marc Dobson, Janek Bechtel, FV Valencia, Yang Yang, Olivér Surányi, Cristina Oropeza Barrera, Suat Ozkorucuklu, Wei Xie, Mariarosaria D'Alfonso, Mario Galanti, Zoltan Szillasi, Jussi Viinikainen, Rainer Wallny, Daniel Abercrombie, Haifa Rejeb Sfar, Umberto Dosselli, Yonghoon Lee, Dhanush Anil Hangal, Marcos Cerrada, Yousen Zhang, Sebastian Wozniewski, Chuyuan Liu, Alessandro Giassi, Giacomo Ortona, Donghyun Song, David Michael Morse, Aditee Rane, Maurizio Pierini, Kai-Feng Chen, David Cussans, Kevin Nash, Thea Klaeboe Aarrestad, Matthew Jones, Alexei Raspereza, Christoph Heidecker, Prafulla Saha, Jared Sturdy, Doris Eckstein, Achim Geiser, Batoul Diab, Efe Yazgan, Luciano Orsini, Liuyao Zhang, Luca Pacher, Gouranga Kole, Jean-Baptiste Sauvan, Shamik Ghosh, Gigi Rolandi, Ernesto Migliore, Hans-Jürgen Simonis, Ettore Focardi, John Rander, Thomas Klijnsma, Thomas Schuh, Giuseppe Iaselli, Georgi Sultanov, Armando Bermúdez Martínez, Francesco Carnevali, Evan Wolfe, David Stuart, Alice Mignerey, Matej Roguljic, Todd Adams, Andrew Wightman, Wit Busza, Mohit Gola, Wajid Ali Khan, Bodhitha Jayatilaka, Andrei Gritsan, Jonathan Guiang, Nadezda Chernyavskaya, Gabor Istvan Veres, Andrey Uzunian, Stefanos Leontsinis, Juska Pekkanen, Luigi Benussi, Francisco Ignacio Garcia Fuentes, Emanuele Usai, Markus Spanring, Soumya Mukherjee, Alice Bean, Luis Ignacio Estevez Banos, David Cutts, Gian Luca Pinna Angioni, Kevin Stenson, Daniel R Claes, Stefano Argiro, Nicolaus Kratochwil, Gourab Saha, Valentina Dutta, Anton Karneyeu, Balazs Ujvari, Yuri Musienko, Javier Cuevas, Mostafa Mahdavikhorrami, Claire Shepherd-Themistocleous, Michael Wassmer, Antonis Agapitos, Salvatore Nuzzo, Philippe Bloch, Martina Vit, Matteo Pisano, Matthias Schnepf, Ilirjan Margjeka, Marcello Abbrescia, Ivan Amos Cali, Ulascan Sarica, Daniel Denegri, Maria Toms, Magda Diamantopoulou, Tamas Ferenc Csorgo, Cristian Baldenegro Barrera, Zhenbin Wu, Giovanni Petrucciani, Gillian Kopp, Bhawna Gomber, Tobias Kramer, Chayanit Asawatangtrakuldee, Philip Keicher, Vladimir Epshteyn, Kaya Tatar, Marcello Mannelli, Christian Schwanenberger, Francesco Brivio, Daniel Rosenzweig, Hideki Okawa, Laurits Tani, Liam Wezenbeek, Yuta Takahashi, Caterina Aruta, A Dodonova, Danila Tlisov, Nurfikri Bin Norjoharuddeen, Achim Stahl, Laurent Forthomme, Lorenzo Bianchini, Colin Jessop, Manuel Olmedo Negrete, David Petyt, Uttiya Sarkar, Hans Rykaczewski, Jian Wang, Alexander Toropin, Jesus Puerta Pelayo, Norbert Neumeister, Yiwen Wen, Sarah Catherine Eno, Sioni Summers, Mikko Voutilainen, Weinan Si, Jan-Frederik Schulte, Sumit Keshri, Federica Maria Simone, Margaret Eminizer, Debabrata Bhowmik, Jochen Schieck, A. Abreu, Andrea Piccinelli, Nancy Marinelli, Qiang Li, Jeremie Alexandre Merlin, Hartmut Stadie, Changwoo Joo, Alessandro Calandri, Sebastian White, Chiara Mariotti, A. C. Bundock, Nabarun Dev, Viacheslav Bunichev, Johan Borg, Maksym Titov, Philip Baringer, Tu Thong Tran, George Stephans, Pritam Palit, Cesar Augusto Bernardes, Matthew Kilpatrick, Felipe Torres Da Silva De Araujo, Natascha Krammer, Rohith Saradhy, M Nickel, Arash Jofrehei, Conor Henderson, Matthias Kasemann, Luca Giommi, Cole Lindsey, Samuel Nathan Webb, Giovanni Mocellin, Francesco Pandolfi, Inna Kucher, Vyacheslav Valuev, M. Mohammadi Najafabadi, Paola Salvini, Emil Sørensen Bols, Panja-Riina Luukka, Roberto Salerno, Vladimir Makarenko, Scarlet Norberg, Federico Ferri, Douglas Berry, Ren-Yuan Zhu, Pascal Vanlaer, Igor Azhgirey, Frank Golf, Jelena Mijuskovic, Richard Breedon, Virgil E Barnes, Irakli Lomidze, Andrzej Novak, Efe Yigitbasi, Emanuela Barberis, Christina Snyder, Avraham Yagil, Graham Wilson, Zviad Tsamalaidze, Steffen Albrecht, Ralf Florian Von Cube, Petr Volkov, Vukasin Milosevic, Alessio Ghezzi, Pietro Vischia, Nikkie Deelen, Manuel Alejandro Segura Delgado, Dmitry Eliseev, Joao Seixas, Francisco Matorras, Houmani El Mamouni, Marco Monteno, Hannes Sakulin, Min Suk Kim, Titas Roy, Ohannes Kamer Köseyan, Marco Musich, Georgy Antchev, Ioanna Papavergou, David Sperka, Gaelle Boudoul, Michael Dittmar, Ram Krishna Dewanjee, Bora Isildak, Jonas Rübenach, Konstantin Matchev, Jean-Marie Brom, Joona Havukainen, Abideh Jafari, Mate Csanad, Jack King, Kuntal Mondal, Ketino Kaadze, Alexis Kalogeropoulos, Plamen Iaydjiev, Michael Lukasik, Paraskevas Gianneios, Robert Hirosky, Tommaso Tedeschi, Marcos Fernandez, M. Lazarovits, Shawn Zaleski, Antonio Cassese, Camille Camen, Radia Redjimi, Florian Beaudette, Alexey Volkov, Paul Sheldon, Charalambos Nicolaou, Arun Muthirakalayil Madhu, Rishi Patel, Alessio Boletti, Jie Zhang, Andres Mateus Vargas Hernandez, Francesca Romana Cavallo, Juan Pablo Fernández Ramos, Daniel Arcaro, Christina Wang, Marek Walczak, Daniel Winterbottom, Thorben Quast, Shudhashil Bharthuar, Marcella Diemoz, Niki Saoulidou, Cecilia Elena Gerber, P. Bärtschi, Johannes Haller, Oliver Pooth, Diego Beghin, Andrej Saibel, Olmo Cerri, Alexx Perloff, Roman Ryutin, Olena Hlushchenko, Federica Primavera, Roberto Carlin, Tariq Aziz, Dave M Newbold, Vadim Oreshkin, Byung Hun Oh, Aleksandar Aleksandrov, Jacob Linacre, Bernard Ille, Oleg Teryaev, Izzeddin Suat Donertas, Livia Soffi, Pierre Depasse, Vyacheslav Klyukhin, Victor Golovtcov, Viktor Savrin, Mitchell Wayne, Karol Bunkowski, Sandeep Kaur, M. J. Kim, Giacomo Bruno, Ian Mcalister, Manuel Calderon De La Barca Sanchez, Tanvi Wamorkar, Taha Beyrouthy, Andrés Cabrera, Tuure Tuuva, Unki Yang, Dinko Ferencek, Caleb Smith, Chiara Aime, Christopher Seez, Andrea García Alonso, Xavier Coubez, Yuichi Kubota, Gilles De Lentdecker, Andreas Albert, Maciej Malawski, Xin Chen, Shih-Chang Lee, Fabrice Couderc, Giovanni Franzoni, Ashok Kumar, Mariana Araujo, Daniel Savoiu, Ozgun Kara, Saranya Ghosh, Olivier Davignon, Dmitri Konstantinov, Sercan Sen, Leonardo Lunerti, Andre Govinda Stahl Leiton, Ramkrishna Sharma, Erik Butz, Teresa Rodrigo, Daniel Gastler, Souvik Das, A. Samalan, Tilman Rohe, Samila Muthumuni, Jing Wang, Sara Nabili, Michele Bianco, Antoine Lesauvage, Po-Hsun Chen, Stefano Mersi, Mykyta Haranko, Hyonsan Seo, Krunal Gedia, Anna Teresa Meneguzzo, Joern Schwandt, Aurélien Carle, Luigi Guiducci, Gregory R Snow, Cesar Atzin Mondragon Herrera, Egidio Longo, Deniz Sunar Cerci, Laszlo Gutay, Paolo Dini, Péter Major, Fabio Ravera, Maren Tabea Meinhard, Rogelio Reyes-Almanza, Igor Volobouev, Hirak Bandyopadhyay, Özlem Özçelik, Diogo Bastos, Cheng Chen, Francisco Yumiceva, Eshwen Bhal, Ritva Kinnunen, Márton Bartók, Haneol Lee, Werner Sun, Santeri Laurila, Christian Dziwok, Emmanuel Olaiya, Alexander Schmidt, Yen-Jie Lee, Dipak Kumar Mishra, Simone Bologna, Nadir Daci, Thoth Gunter, Giorgio Maggi, Georg Steinbrück, Marko Dragicevic, Kirti Ranjan, Willard Johns, Monika Bharti, Javier Andres Brochero Cifuentes, James Alexander, Douja Darej, Anna Tsatsos, Lukasz Kreczko, Sadia Khalil, Stefan Grünendahl, Sam Harper, Evan Koenig, Alain Givernaud, Amedeo Staiano, Robert Schöfbeck, Seth Moortgat, Nicola Turini, Cristina Mantilla, Gabriel Madigan, Kevin Black, Louis Lyons, Ada Solano, Hugues Lattaud, Muhammad Waqas, Izaak Neutelings, Rachael Bucci, Mauro Donegà, Igor Bayshev, Brooks McMaster, Predrag Milenovic, Kisoo Lee, Ismail Okan Atakisi, Kin Ho Lo, Lalit Mohan Pant, Aaron Dominguez, Mithat Kaya, Federico De Guio, Gaetano-Marco Dallavalle, Eliza Melo Da Costa, Alexander Spiridonov, Shuichi Kunori, Jose F Benitez, Lorenzo Viliani, Abhishikth Mallampalli, George Karathanasis, Samuel Higginbotham, Salvatore Costa, Philip Harris, Nikola Godinovic, Hualin Mei, Altan Cakir, Paolo Meridiani, Aron Soha, Rainer Mankel, Mariana Shopova, Henriette Aarup Petersen, Cilicia Uzziel Perez, Petar Maksimovic, Elizabeth Starling, Akshansh Singh, Nan Lu, René Caspart, Rajarshi Bhattacharya, Elisabetta Manca, Nicolò Trevisani, Patrick Janot, Hale Sert, Suyong Choi, Austin Townsend, Etiennette Auffray, D. R. Muller, Milos Dordevic, Carsten Hensel, Javier Fernandez Menendez, Andrea Gelmi, Indara Suarez, Thorsten Chwalek, Yajun Mao, Mikhail Kirsanov, Barbara Clerbaux, Irene Zoi, Marcello Maggi, Davide Piccolo, Anna Stakia, Sébastien Wertz, Raghav Kansal, Sanghyun Ko, Jennifer Ott, Byung-Sik Hong, Mahmod Moussa Abdelkhalek Gadallah, Kevin Mota Amarilo, Michael Hildreth, Matthew Decaro, Walaa Elmetenawee, A. Álvarez Fernández, Francesca Nessi-Tedaldi, Eric Christian Chabert, Mario Pelliccioni, Oscar Gonzalez Lopez, Natalia Lychkovskaya, Ilia Zhizhin, Anne Dabrowski, Bryan Caraway, Miguel Alves Gallo Pereira, Robert White, Paolo Azzurri, Pablo Matorras Cuevas, Günther Dissertori, Yi Chen, Timo Peltola, Sandeep Bhowmik, Thiago Tomei, Michael Schmitt, Vishwajeet Jha, Salvatore Rappoccio, Chad Freer, Vladislav Shalaev, Carlo Rovelli, Walter Luiz Aldá Júnior, Felicitas Pauss, Celso Martinez Rivero, Celia Fernandez Madrazo, Laurent Mirabito, Pushpalatha C Bhat, Biagio Rossi, Kirika Uchida, Sudarshan Paramesvaran, Victor Daniel Elvira, Prabhat Ranjan Pujahari, Dan Quach, Junho Choi, Ron Lipton, Yongho Jeong, Cristina Tuve, Humberto Antonio Salazar Ibarguen, Alexander Pauls, Alex Dorsett, Christoph Grab, Chun Cheng, Martin Delcourt, Andreas Werner Jung, Henning Kirschenmann, Edouard Boos, Sinan Sagir, Walter Van Doninck, Negin Shafiei, Hesham El Faham, Silvio Donato, Mohsen Khakzad, Maria Isabel Josa, Patrick Connor, Andre David Tinoco Mendes, Roberto Dell'Orso, Sergey Troshin, Ian Reed, Kun Shi, Jaana Kristiina Heikkilä, Shashikant Dugad, David D'Enterria, Eva Halkiadakis, Yong Ban, Otto Hindrichs, Aashaq Shah, Frank Glege, Cheng-Chieh Peng, Tanmay Sarkar, Matthew Joyce, Miroslav Finger, Andrei Oskin, Ac Williams, Simone Giani, Rosamaria Venditti, Borislav Pavlov, Pablo Martinez Ruiz del Arbol, Tulika Bose, Vladimir Karjavine, Chandiprasad Kar, Jingyan Li, Urs Langenegger, Muriel Vander Donckt, M. Teklishyn, T. Tabarelli de Fatis, Janik Walter Andrejkovic, Mohammad Alhusseini, Loukas Gouskos, Vinaya Krishnan Muraleedharan Nair Bindhu, Ilknur Hos, Senne Van Putte, Arnab Purohit, Steven Lowette, Bilal Kiani, Balaji Venkat Sathia Narayanan, Csaba Hajdu, Wael Haj Ahmad, Emyr Clement, Saikat Karmakar, Diego Matos Figueiredo, Manuel Aguilar-Benitez, Claudio Caputo, Harry Cheung, Peter Schleper, Zhen Hu, Keith Ulmer, Ota Kukral, Andrew Hart, Angira Rastogi, Jiwon Park, Ayse Polatoz, Demetrios Loukas, Kalpanie Liyanage, Austin Baty, Stephane Cooperstein, Mario Masciovecchio, Stefano Marcellini, John Strologas, Theodoros Geralis, Andrea Rizzi, Amal Sarkar, Frank Hartmann, Paolo Giacomelli, Varun Sharma, Natalia Emriskova, Dzmitry Budkouski, Shin-Shan Yu, Dario Soldi, Oleksandr Viazlo, Davide Di Croce, Bisnupriya Sahu, Andrew Levin, Edoardo Bossini, Evan Ranken, Alexander Malakhov, Günter Flügge, Danyyl Brzhechko, Sangeun Lee, Marius Teroerde, Michael Finger Jr, Laurent Pétré, Georgia Karapostoli, Florian Joel J Bury, Yangyang Cheng, Helio Nogima, Sebastian Wieland, Davide Valsecchi, Elif Asli Yetkin, Alberto Orso Maria Iorio, Felice Pantaleo, Yuan Chen, Km Alpana, Pritam Kalbhor, Sanjeev Kumar, Nikitas Loukas, Martha Nunez Ornelas, Bożena Boimska, Kerem Cankocak, Tahys Janssen, Harrison Prosper, Anton Stepennov, Andrea Bocci, Crisostomo Sciacca, Maxim Goncharov, Mario Deile, Stephen Robert Wagner, Kak Wong, Anadi Canepa, Dario Menasce, Claire Savard, Simranjit Singh Chhibra, Ali Eren Simsek, David Barney, Aleksandra Lelek, Eda Eskut, Stephanie Beauceron, Huilin Qu, Rachel Bartek, Marco Peruzzi, Usama Hussain, Owen Rosser Long, Geoffrey Hall, Nicola Amapane, Georgios Tsipolitis, Yeonju Go, Andrew Loeliger, Christophe Ochando, Francesco Santanastasio, Stoyan Stoynev, Sergo Jindariani, Bruno Lenzi, Wenyu Zhang, Florian Michael Pitters, Ksenia De Leo, Irene Bachiller, Luka Lambrecht, Cristina Biino, Rino Castaldi, Ivan Mikulec, M. Naimuddin, Giovanni Abbiendi, Valerie Scheurer, Amandeep Kaur Kalsi, Leonard Spiegel, Francesco Romeo, Robert Klanner, Andrea Benaglia, Gabriel Ayala, Darin Acosta, Kristian Allan Hahn, Jorge F de Trocóniz, Natalia Korneeva, Mark Raymond Adams, Ulrich Husemann, Stephanie Kwan, Alexander Bylinkin, Valentina Sola, Fabio Monti, Maksim Azarkin, David Anthony, Andrea Malara, Beatriz Ribeiro Lopes, Basil Schneider, Krisztián Farkas, Antonio Vilela Pereira, Robert Clare, Lucas Torterotot, Patrizia Azzi, Ahmad Lotfy, Sihyun Jeon, Pirmin Berger, Tommaso Dorigo, Benjamin Charles Radburn-Smith, Sandra Malvezzi, Ken W Bell, Christine Nielsen, James Letts, Guillaume Bourgatte, Pedro José Fernández Manteca, Andrey Popov, Doyeong Kim, Johann Rauser, Fanbo Meng, Jhovanny Mejia Guisao, Caroline Collard, Mikko Lotti, Grace Cummings, Jan Van Der Linden, Vipin Bhatnagar, Danilo Piparo, Georgios Anagnostou, Melody A. Swartz, Maxwell Chertok, Francesco Fienga, Pietro Faccioli, Roy Montalvo, Zoltan Laszlo Trocsanyi, J. Conway, D. Del Re, Dong Hee Kim, Vincent Lemaitre, Daniele Trocino, Elisabetta Gallo, Vincenzo Ciriolo, Peter Robmann, Andrey Belyaev, Tiziano Camporesi, L. Brigliadori, Brent Stone, Seema Sharma, Sitong An, Louise Skinnari, Nural Akchurin, David Walter, N. G. Redaelli, Hannu Siikonen, Frank Jensen, Marco Bozzo, Martina Malberti, Jay Dittmann, Daniel Teyssier, Leonid Kardapoltsev, Richard D Field, Marco Pieri, Apichart Hortiangtham, Pawan Kumar Netrakanti, Christoph Garbers, Muhammad Ansar Iqbal, Ian R Tomalin, Evgueni Tcherniaev, Victor Perelygin, Alessandra Fanfani, Mintu Kumar, Andreas Nowack, Dezso Horvath, Christina Reissel, Ryan Mueller, Michael Pitt, Shane Breeze, Illia Babounikau, Alessia Tricomi, Andrew Askew, Nicholas Menendez, Nikolay Tyurin, Olena Karacheban, Styliani Orfanelli, Thomas Hebbeker, Paul Lecoq, Thomas Bergauer, Miao Hu, Carlos Willmott, Jorge Fraga, Alexandre Hakimi, Danek Kotlinski, Iban Jose Cabrillo, Chang-Seong Moon, Koushik Mandal, Paraskevas Sphicas, Eric Appelt, Savvas Kyriacou, Denis Rathjens, Catherine Schiber, Mauro Emanuele Dinardo, Sven Dildick, Nhan Viet Tran, Mohammad Abrar Wadud, Christof Roland, Maria Del Mar Capeans Garrido, Alberto Zucchetta, Alexander Dierlamm, Ashish Sehrawat, Ashraf Mohamed, David Saltzberg, José David Ruiz Alvarez, Eric Wayne Vaandering, Vladimir Palichik, Ivan Reid, Christine Mclean, Anastasia Grebenyuk, Vitalii Okhotnikov, Tomas Kello, Petar Adzic, Charis Kleio Koraka, Maria Margherita Obertino, Michal Szleper, Philippe Gras, Samuel Bright-Thonney, Chia-Ming Kuo, Karl Gill, Bora Akgun, Colin Fallon, Sudhir Malik, Ankush Reddy Kanuganti, Sandra Consuegra Rodríguez, Simon Christoph Schuler, Ia Iashvili, Roberto Seidita, Giuseppe Barbagli, János Karancsi, Monoranjan Guchait, Adriano Di Florio, Jean-Roch Vlimant, Ksenia Shchelina, Steffie Ann Thayil, Ece Aşılar, Yao Yao, Simone Pigazzini, Grigory Pivovarov, Yacine Haddad, Antonio Ranieri, Maxim Perfilov, Lucas Corcodilos, Antonin Kveton, Mauro Menichelli, Roland Horisberger, David Colling, Amina Zghiche, Michael Reichmann, Kamuran Dilsiz, Seema Bahinipati, Paolo Rumerio, Lorenzo Uplegger, William T. Ford, Alexandre Zabi, Roumyana Hadjiiska, Igor Smirnov, Muhammad Irfan Asghar, Candan Dozen, Michele Gallinaro, Kerstin Hoepfner, Eirini Tziaferi, Richard Loveless, Michael Wayne Arenton, Alexander Fröhlich, Joshuha Thomas-Wilsker, Davide Fiorina, Attila József Rádl, Paul Baillon, Siddhesh Sawant, Artur Apresyan, Albert De Roeck, Yuan Chao, Marc Besancon, Dinyar Rabady, Jan Steggemann, Konstantin Androsov, Michele Arneodo, Garvita Agarwal, Dener De Souza Lemos, Panagiotis Kokkas, Marino Missiroli, Wolfram Dietrich Zeuner, Ka Tung Lau, Leonid Didukh, Brieuc Francois, Brajesh C Choudhary, Andrea Trapote, Dmitry Hits, Jorma Tuominiemi, Maria Cruz Fouz, Alexander Droll, Susan Gascon, Robin Aggleton, Andreas Nürnberg, Prasanna Siddireddy, Sébastien Viret, Gian Piero Siroli, Niels Dupont, Riccardo Del Burgo, Jaehyeok Yoo, Antoni Shtipliyski, Eduard De La Cruz-Burelo, Gaël Touquet, Emily MacDonald, Danilo Meuser, Andrew Gilbert, Metin Yalvac, Stephan Lammel, Gianny Mestdach, Marijus Ambrozas, Anton Babaev, Ridhi Chawla, Jona Motta, Jeremi Niedziela, Meenakshi Narain, Theodor Christian Herwig, Daniel Robert Marlow, Tahir Javaid, Eric Adams, Tommaso Isidori, Junquan Tao, Dennis Noll, Hsin-yeh Wu, Peter Wittich, Alessandro Tarabini, Pierre Van Mechelen, Amandeep Kaur, Andrius Juodagalvis, Christopher Rogan, Xuyang Gao, Shalini Thakur, Daniele Pedrini, Chiara Amendola, Benedikt Maier, Tagir Aushev, Daniel Noonan, Corrinne Mills, A. Bethani, Francesco Fabozzi, James John Brooke, Cédric Prieels, Stefaan Tavernier, Gabriel Ramirez-Sanchez, Xuejun Wang, Long Wang, Praveen Chandra Tiwari, Álvaro Navarro Tobar, Inna Makarenko, Akram Khan, Mia Tosi, J. Bonilla, Victor Shang, Guillaume Falmagne, Imad Baptiste Laktineh, Lucas Taylor, Matthew Citron, Olaf Behnke, Marco Cuffiani, Diego Ciangottini, Andrea Perrotta, Jose Monroy, Giulia Sorrentino, Prashant Shukla, Kenneth Bloom, Leonardo Giannini, Rui Zou, Mar Barrio Luna, Cristina Fernandez Bedoya, Emery Nibigira, Isabel Pedraza, Hannsjoerg Artur Weber, Sunil Somalwar, Thomas McCauley, Nicolas Chanon, Helena Malbouisson, Erich Schmitz, Camelia Mironov, Tongguang Cheng, Oleksii Turkot, Fabrizio Gasparini, Michele Selvaggi, Antonello Pellecchia, M. Choi, Shirin Chenarani, Valentina Avati, Lutz Feld, Tommaso Boccali, Jonatan Piedra Gomez, Anton Petrov, Quan Wang, Danyer Pérez Adán, W. Jang, Maria Agnese Ciocci, Dave Pellett, Marko Kovac, Maria Florencia Canelli, Malgorzata Kazana, Yves Sirois, Gordon H. Hanson, Michel Della Negra, Gulsen Onengut, Viktor Matveev, Sergio Sanchez Cruz, Dmitrii Kirpichnikov, John Alison, Víctor Rodríguez Bouza, Gunther Roland, Mikhail Danilov, Guillermo Reales Gutiérrez, Pieter David, Brendan Regnery, André Rosowsky, Andrew Ivanov, Olga Evdokimov, Junghwan Goh, Natasa Raicevic, Livio Fanò, Fabrizio Ferro, Aurore Savoy-Navarro, Kerstin Borras, Diana Seitova, Thomas Ferbel, David Gabriel Monk, Dan Green, Fuqiang Wang, Sergey Polikarpov, Andrew Rose, Oliver Buchmuller, Luca Mastrolorenzo, David Ja Cockerill, Wolfgang Lange, Gianni Masetti, Salavat Abdullin, Frans Meijers, Stephen Trembath-Reichert, Emilien Chapon, Vittorio Raoul Tavolaro, Andrea Delgado, Hessamoddin Kaveh, Sascha Pascal Liechti, Duncan Leggat, Marta Ruspa, Mehdi Rahmani, Edward Scott, Filippo Errico, Jozsef Molnar, Valerio Re, Joscha Knolle, Gianni Zumerle, Sunil Bansal, Anup Kumar Sikdar, Gerry Bauer, A.N. 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Williams, Agostino De Iorio, Catherine Adloff, Henning Keller, Kurtis F Johnson, Bayram Tali, Seyed Mohsen Etesami, James Hirschauer, Nimantha Perera, Nick Van Remortel, Merijn Van De Klundert, Greg P Heath, Alfredo Gurrola, Ufuk Guney Tok, Stefan Piperov, Arnab Laha, Khawla Jaffel, Abhisek Datta, Dimitrios Karasavvas, Riccardo Salvatico, Christopher Brew, Christopher Brainerd, William Tabb, Maxime Gouzevitch, Markus Seidel, Vaia Papadimitriou, Vineet Kumar, Vieri Candelise, Gintautas Tamulaitis, Lothar At Bauerdick, Sabino Meola, Roberto Covarelli, Thong Nguyen, Nicholas Manganelli, Sergio Cittolin, Liliana Teodorescu, Adolf Bornheim, Ted Kolberg, Jean-Charles Fontaine, Sijing Zhang, Muhammad Shoaib, Abanti Ranadhir Sahasransu, Yutaro Iiyama, Geonhee Oh, Anton Dimitrov, S. 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Singh, Didar Dobur, Himal Acharya, Jin Wang, Deborah Pinna, Pedrame Bargassa, Bekhzod S Yuldashev, Kadir Ocalan, Zhixing Wang, Federica Legger, Vladimir Blinov, Nathaniel Odell, Daniel Diaz, Julia Thom, Katie Walkingshaw Pass, Srinidhi Bheesette, Nick Amin, Kyle Cormier, David Mark Raymond, Christophe Delaere, Dipanwita Dutta, Meena Meena, Tribeni Mishra, Alexei Safonov, Christophe Royon, Elizabeth Sexton-Kennedy, Luc Pape, William Arthur Nash, Nikolay Voytishin, Vassili Kachanov, Moritz Guthoff, Marc Weber, Bobae Kim, Matthias Wolf, Kira Burt, Victor Kim, Willem Verbeke, Armando Lanaro, Finn Rebassoo, Reham Aly, James Sheplock, Eleni Erodotou, Mehar Ali Shah, Paolo Ronchese, J. E. Kim, Marta Tornago, Badder Marzocchi, Sanjay Kumar Swain, Alice Florent, Michael Revering, Julia Velkovska, Pieter Everaerts, Sudha Ahuja, Halil Saka, Pietro Govoni, M Myllymäki, Candan Isik, Simon Regnard, Marc M Baarmand, D. Y. 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William Gary, Valeria D'Amante, Victor Murzin, Sandhya Jain, Florian Eble, J. Thieman, Manfred Paulini, Jessica Prisciandaro, Milan Stojanovic, Katja Klein, Ugo Gasparini, Nicola Cavallo, Ashish Sharma, Sara Fiorendi, Camilo Andrés Salazar González, Vasken Hagopian, Mohammed Mahmoud, Bhargav Madhusudan Joshi, Georgios Krintiras, Matteo Presilla, Zeynep Demiragli, Marina Kolosova, Yalcin Guler, Stefan A. Maier, M. Magherini, Roger Wolf, Yongsun Kim, Lev Dudko, Jeremy Andrea, Redwan Habibullah, Hong Ni, Luca Guzzi, Roberto Mulargia, Dylan Gilbert, Toms Torims, Pierluigi Zotto, Kousik Naskar, Robert Bainbridge, Gobinda Majumder, Simona Cometti, Stefano Ragazzi, Jane Nachtman, Mateo Ramírez García, Sergio F Novaes, Morgan Lethuillier, Yasar Onel, Michael Krohn, Piotr Zalewski, Ignacio Redondo, Dylan Lutton, Yurii Maravin, Vladimir Gavrilov, Hongbo Liao, Aleko Khukhunaishvili, Alexandra Tews, Spandan Mondal, Leonardo Cristella, Hannes Jung, Alexander Zhokin, Vitaly Smirnov, Martijn Mulders, Marius Metzler, Sushil Chauhan, John Lawrence, Anna Colaleo, Kamal Lamichhane, Mary Hadley, Martino Margoni, Daniel Guerrero, Nuno Leonardo, Ashutosh Bhardwaj, Jan Kieseler, Giulia Negro, J. O. Gosewisch, J. 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Flowers, Sergei Gninenko, Petr Mandrik, Sudeshna Banerjee, Vladimir Andreev, Senka Duric, Benjamin Tannenwald, Guler Karapinar, Juan Rodrigo González Fernández, Sandro Fonseca De Souza, Aruna Nayak, Samet Lezki, Gervasio Gomez, Archana Sharma, Sung Won Lee, Samuel May, Giuseppe Latino, Ravindra Kumar Verma, Elisa Fontanesi, Vinay Hegde, Saptaparna Bhattacharya, David Zou, Finn Feindt, Andrey Korytov, Nairit Sur, Dylan Apparu, Eduardo De Moraes Gregores, Michael Oshiro, Ashfaq Ahmad, Vladimir Korenkov, John Paul Chou, Rishabh Uniyal, Ashim Roy, Afiq Aizuddin Bin Anuar, Andre Frankenthal, Brian Paul Padley, Justin Williams, Zhaozhong Shi, Jung-Hyun Kim, Timothy Koeth, Jan Krolikowski, Luiz Mundim, Duccio Abbaneo, Matteo Bonanomi, Isa Dumanoglu, Elizabeth Locci, Ilaria Vai, Gabriele Benelli, Gregory Iles, Ruchi Chudasama, Sergio Lo Meo, Alexis Pompili, Maria Savina, Abraham Tishelman-Charny, Ang Li, Stephen Wimpenny, Henning Flacher, J. Wanczyk, Nikolaos Manthos, Adel Terkulov, Neha Rawal, Caglar Zorbilmez, Lorenzo Vigilante, Martin Grunewald, Emrah Tiras, Toyoko Orimoto, Nicolas Stylianou, Luciano Romero, Bolek Wyslouch, Amandeep Singh Bakshi, Oleg Prokofyev, Wolfram Erdmann, Alp Akpinar, Nicolo Cartiglia, Rajat Gupta, Maria Spiropulu, Christian Dorfer, Serguei Ganjour, Maria Giulia Ratti, Matthew Herndon, Juan Alcaraz Maestre, Vasilije Perovic, Mei-li Holmberg, Thomas James, Elsayed Salama, Raphael Granier de Cassagnac, Darien Wood, Sevgi Tekten, Jithin Madhusudanan Sreekala, Fabio Cossutti, Jyothsna Rani Komaragiri, Satyaki Bhattacharya, Konstantin Shchablo, Karim El Morabit, Jovan Milosevic, Mareike Meyer, Vitaliano Ciulli, J. Pata, Ian Watson, Isabell-Alissandra Melzer-Pellmann, Nicholas John Hadley, Jehad Mousa, Jae Sung Kim, Karl Matthew Ecklund, Bennett Greenberg, Maral Alyari, Giuseppe Bagliesi, Apostolos Panagiotou, Benjamin Kilminster, Hyun-Soo Kim, Benjamin Fischer, Bingran Wang, Sung Bin Oh, Duje Giljanovic, Cristina Martin Perez, Christopher West, Jonas Roemer, Kai Yi, Tatjana Susa, Si-Jin Qian, Isabel Ojalvo, Youn Roh, Barry Blumenfeld, Vladimir Chekhovsky, Andrea Cardini, Garyfallia Paspalaki, Alain Hervé, Yuri Skovpen, Hwi Dong Yoo, Ivan Vila, Suman Chatterjee, Tomas Lindén, Carlo Civinini, Fabio Iemmi, Bhumika Kansal, Christoph Schwick, Richard Lander, Clara Ramón Álvarez, Walter Snoeys, Simone Gennai, G. Gomez Ceballos, Nikos Varelas, Helen F Heath, Joshua Hiltbrand, Prasant Kumar Rout, Riccardo Paramatti, Andrea Giammanco, Priyanka Kumari, Alberto Escalante Del Valle, W. A. T. Wan Abdullah, Deshitha Chamikara Wickramarathna Dhammage, Jason Gilmore, Marco Paganoni, Don Lincoln, Li Yuan, Jory Sonneveld, Hafeez R Hoorani, Dietrich Liko, Mykhailo Dalchenko, Manfred Jeitler, Tamás Álmos Vámi, Sungwoong Cho, Fabrizio Palla, Andrew Melo, Owen Baron, Steve Schnetzer, Klaas Padeken, Renato Campanini, Gautier Hamel de Monchenault, Prafulla Kumar Behera, Roland Koppenhöfer, Melissa Quinnan, Carlos Lourenco, Riccardo Andrea Manzoni, Christian Veelken, Annapaola De Cosa, Drew Baden, Max Neukum, Markus Klute, Joel Goldstein, Luciano Ristori, Milena Misheva, Luigi Calligaris, Kevin Pedro, Tiehui Liu, Robert Lee, Silvano Tosi, Ryan Heller, Daniel Treille, Kelvin Mei, D. De Jesus Damiao, Sebastian Wuchterl, Tamas Novak, German Martinez, Cristina Botta, Jonathon Langford, Viesturs Veckalns, David Brunner, Arnd Meyer, Dario Bisello, Pascal Paganini, Jonas Rembser, David Stickland, Hassan Abdalla, Daniel Pitzl, Joaquin Emilo Siado, Paolo Montagna, Thomas Berger, Othmane Bouhali, Carlos Erice, David Mason, Luigi Moroni, Luca Lista, Pei-rong Yu, James G Branson, He He, David Krofcheck, Jonathan Hollar, Merve Ince, Willis Lin, Andrew Evans, Markus Merschmeyer, Arie Bodek, Ozlem Kaya, Sevil Salur, Joseph Reichert, Eddi A De Wolf, S. Sánchez Navas, Jose Chinellato, Richard Cavanaugh, Marco Rovere, Alexander Richards, Jorge Berenguer Antequera, Marco Toliman Lucchini, Mauricio Thiel, Ilya Gorbunov, Peter Timothy Cox, Torben Lange, Michael Mulhearn, Jie Xiao, Ilya Kravchenko, Jeroen Hegeman, Anatoli Zarubin, Ran Bi, Katarzyna Wichmann, S. Seif El Nasr-storey, Abdollah Mohammadi, Seth Cooper, Francesca Maria Addesa, Semra Turkcapar, Viktor Kutzner, Linda Finco, Alfredo Castaneda Hernandez, Mingshui Chen, Monika Mittal, Scott Thomas, Piero Giorgio Verdini, Ludivine Ceard, Matevz Tadel, Yannik Rath, Viola Sordini, Erika Garutti, Giancarlo Mantovani, Carlo Battilana, Sezen Sekmen, Inseok Yoon, M. Campana, K. Osterberg, Ziheng Chen, Maximilian Heindl, Claus Kleinwort, Alexander Savin, Minseok Oh, Francesca Cavallari, Stefano Belforte, Guido Andreassi, Massimo Casarsa, Thomas Müller, Andrés G Delannoy, Christopher Hill, Pawel de Barbaro, Vilius Cepaitis, Anne-mazarine Lyon, Alexander Dermenev, Patrick Bryant, Vincenzo Mastrapasqua, Dong Ho Moon, Nikolai Krasnikov, Sami Lehti, Adish Vartak, Umberto Molinatti, Brandon Bonham, Valentina Mariani, Ivan Shvetsov, Z Warner, Igor Golutvin, Mircho Rodozov, Serguei Volkov, Maria Aldaya Martin, Jiwoong Kim, Nicola Bacchetta, Attila Racz, Roberta Arcidiacono, Anatoli Pashenkov, Avto Kharchilava, Mikhail Ignatenko, Tapio Lampén, Fabrizio Fabbri, Christoph Wissing, Norraphat Srimanobhas, Dermot Moran, S. Wunsch, Caleb Fangmeier, Vinicius Massami Mikuni, Quentin Ingram, Francesco Fallavollita, Simon Fayer, Julie Managan Hogan, Panos A Razis, Samuel Baxter, Sifu Luo, Sergei Slabospitskii, Mark Saunders, Anne-Catherine Le Bihan, Tyler Lam, Nadja Strobbe, Jean-Laurent Agram, Lauren Hay, Jim Freeman, Philip Chang, Brent Yates, Geum Bong Yu, Alberto Bragagnolo, Begona De La Cruz, Aristotelis Kyriakis, Cecilia Uribe Estrada, Welathantri Gd Dharmaratna, Ferenc Sikler, Dayong Wang, Mauro Verzetti, Mario Kadastik, Ashley Parker, Kinga Anna Wozniak, Kai Wei, Rachel Yohay, F. Simonetto, Belforte, S., Candelise, V., Casarsa, M., Cossutti, F., DA ROLD, A., DELLA RICCA, G., Sorrentino, G., Vazzoler, F., ET AL (the CMS, Collaboration), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), CMS, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)
Subjects: (stop neutralino) [mass difference], Top quark, transverse momentum: missing-energy, final state: ((n)jet), Physics and Astronomy (miscellaneous), Proton, 13000 GeV-cms, mass: lower limit [neutralino], ((n)jet dilepton) [final state], pair production [top], channel cross section: upper limit, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], scattering [p p], stop: mass: lower limit, squark: pair production, mass: lower limit [squark], Nuclear Experiment, massless [neutralino], Physics, Large Hadron Collider, upper limit [channel cross section], CMS, mass difference: (stop neutralino), neutralino: mass: lower limit, mass: lower limit [stop], 3. Good health, Massless particle, CERN LHC Coll, kinematics, PARTICLE PHYSICS, colliding beams [p p], top: pair production, Particle Physics - Experiment, signature, stop: pair production, ((n)jet lepton) [final state], p p: scattering, Particle physics, CERN Lab, neutralino: massless, Dark matter, final state: ((n)jet lepton), FOS: Physical sciences, parameter space [supersymmetry], dark matter: associated production, ((n)jet) [final state], 0103 physical sciences, Physics::Atomic and Molecular Clusters, ddc:530, pair production [stop], 010306 general physics, Engineering (miscellaneous), pair production [squark], LARGE HADRON COLLIDER, final state: ((n)jet dilepton), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, High energy physics (experiments), SUSY, supersymmetry: parameter space, mediation [dark matter], dark matter: mediation, squark: mass: lower limit, Pair production, missing-energy [transverse momentum], Neutralino, High Energy Physics::Experiment, associated production [dark matter], p p: colliding beams, experimental results, Lepton
Abstract: A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb$^{-1}$ collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on the model, the combined result excludes a top squark mass up to 1325 GeV for a massless neutralino, and a neutralino mass up to 700 GeV for a top squark mass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV., Comment: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/SUS-20-002 (CMS Public Pages)
Published: 2021

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