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1. Preoperative localisation of nonpalpable breast lesions using magnetic markers in a tertiary cancer centre

Author

Petrillo, Antonella, Di Giacomo, Raimondo, Esposito, Emanuela, Vallone, Paolo, Setola, Sergio Venanzio, Raso, Mauro Mattace, Granata, Vincenza, Barretta, Maria Luisa, Siani, Claudio, Rinaldo, Chiara, Donzelli, Ivana, Marone, Ugo, Melucci, Maria Teresa, Fucito, Alfredo, Saponara, Ruggero, Di Bonito, Maurizio, Fusco, Roberta, Rinaldo, Massimo, and Avino, Franca

Published
2022
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2. Baseline Association between Healthy Eating Index-2015 and Health-Related Quality of Life in Breast Cancer Patients Enrolled in a Randomized Trial.

Author

Porciello, Giuseppe, Coluccia, Sergio, Vitale, Sara, Palumbo, Elvira, Luongo, Assunta, Grimaldi, Maria, Pica, Rosa, Prete, Melania, Calabrese, Ilaria, Cubisino, Serena, Montagnese, Concetta, Falzone, Luca, Martinuzzo, Valentina, Poletto, Luigina, Rotondo, Emanuela, Di Gennaro, Piergiacomo, De Laurentiis, Michelino, D'Aiuto, Massimiliano, Rinaldo, Massimo, and Thomas, Guglielmo

Subjects
STATISTICAL significance, RESEARCH funding, BREAST tumors, MULTIPLE regression analysis, SMOKING, QUESTIONNAIRES, MULTIVARIATE analysis, DESCRIPTIVE statistics, HEALTH behavior, FOOD habits, QUALITY of life, RESEARCH, ANALYSIS of variance, CANCER patient psychology, TOBACCO products, DATA analysis software, DIET
Abstract

Simple Summary: Quality of life significantly affects health outcomes in cancer patients. However, evidence of an association between diet quality and quality of life in cancer survivors is sparse in Mediterranean countries. The aim of this study was to evaluate the associations between an a priori diet quality index, the Healthy Eating Index-2015 (HEI-2015), and quality of life, assessed through a validated questionnaire targeted at women with a breast cancer diagnosis. A higher HEI-2015 score was positively associated with summary quality of life score and inversely associated with symptom scores. Health-related quality of life (HRQoL) represents one of the most concerning aspects for cancer patients. The Healthy Eating Index (HEI) is an a priori diet quality index directly associated with health outcomes and HRQoL in cancer survivors in North American populations. We evaluated, in a Mediterranean population, the baseline associations between HEI-2015 and HRQoL in 492 women with breast cancer recruited in a DEDiCa lifestyle trial. Dietary data were obtained from 7-day food records; HRQoL was assessed through the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C30) and the C30 Summary Score (SumSc). Analysis of variance and multivariable linear and log-gamma regression models were performed. Mean and standard deviation for HEI-2015 score was 68.8 ± 11.2; SumSc was 81.5 ± 12.9. Women with lower HEI-2015 score had higher BMI, were more frequently exposed to tobacco smoke and had fewer years of education. Patients with a HEI-2015 score greater than 68.7 (median value) showed a significant increase in SumSc of 4% (p = 0.02). HEI-2015 components also associated with SumSc were beans and greens (β = 1.04; p = 0.02). Weak associations were found for total vegetables and saturated fats. Higher diet quality in breast cancer survivors was associated with higher overall HRQoL in this cross-sectional analysis. [ABSTRACT FROM AUTHOR]

Published
2024
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4. One-year nutrition counselling in the context of a Mediterranean diet reduced the dietary inflammatory index in women with breast cancer: a role for the dietary glycemic index

Author

Vitale, Sara, primary, Palumbo, Elvira, additional, Polesel, Jerry, additional, Hebert, James R., additional, Shivappa, Nitin, additional, Montagnese, Concetta, additional, Porciello, Giuseppe, additional, Calabrese, Ilaria, additional, Luongo, Assunta, additional, Prete, Melania, additional, Pica, Rosa, additional, Grimaldi, Maria, additional, Crispo, Anna, additional, Esindi, Nadia, additional, Falzone, Luca, additional, Mattioli, Veronica, additional, Martinuzzo, Valentina, additional, Poletto, Luigina, additional, Cubisino, Serena, additional, Dainotta, Patrizia, additional, De Laurentiis, Michelino, additional, Pacilio, Carmen, additional, Rinaldo, Massimo, additional, Thomas, Guglielmo, additional, D'Aiuto, Massimiliano, additional, Serraino, Diego, additional, Massarut, Samuele, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Catalano, Francesca, additional, Banna, Giuseppe L., additional, Messina, Francesco, additional, Gatti, Davide, additional, Riccardi, Gabriele, additional, Libra, Massimo, additional, Celentano, Egidio, additional, Jenkins, David J. A., additional, and Augustin, Livia S. A., additional

Published
2023
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6. Correction: Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial

Author

Porciello, Giuseppe, primary, Montagnese, Concetta, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, Libra, Massimo, additional, Vitale, Sara, additional, Palumbo, Elvira, additional, Pica, Rosa, additional, Calabrese, Ilaria, additional, Cubisino, Serena, additional, Falzone, Luca, additional, Poletto, Luigina, additional, Martinuzzo, Valentina, additional, Prete, Melania, additional, Esindi, Nadia, additional, Thomas, Guglielmo, additional, Cianniello, Daniela, additional, Pinto, Monica, additional, De Laurentiis, Michelino, additional, Pacilio, Carmen, additional, Rinaldo, Massimo, additional, D’Aiuto, Massimiliano, additional, Serraino, Diego, additional, Massarut, Samuele, additional, Evangelista, Chiara, additional, Steffan, Agostino, additional, Catalano, Francesca, additional, Banna, Giuseppe L., additional, Scandurra, Giuseppa, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Antonelli, Giovanna, additional, Guerra, Gennaro, additional, Farina, Amalia, additional, Messina, Francesco, additional, Riccardi, Gabriele, additional, Gatti, Davide, additional, Jenkins, David J. A., additional, Minopoli, Anita, additional, Grilli, Bruna, additional, Cavalcanti, Ernesta, additional, Celentano, Egidio, additional, Botti, Gerardo, additional, Montella †, Maurizio, additional, and Augustin, Livia S. A., additional

Published
2021
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8. Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications

Author

Montagnese, Concetta, primary, Porciello, Giuseppe, additional, Vitale, Sara, additional, Palumbo, Elvira, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, Calabrese, Ilaria, additional, Pica, Rosa, additional, Prete, Melania, additional, Falzone, Luca, additional, Libra, Massimo, additional, Cubisino, Serena, additional, Poletto, Luigina, additional, Martinuzzo, Valentina, additional, Coluccia, Sergio, additional, Esindi, Nadia, additional, Nocerino, Flavia, additional, Minopoli, Anita, additional, Grilli, Bruna, additional, Fiorillo, Pasqualina C., additional, Cuomo, Marco, additional, Cavalcanti, Ernesta, additional, Thomas, Guglielmo, additional, Cianniello, Daniela, additional, Pinto, Monica, additional, De Laurentiis, Michelino, additional, Pacilio, Carmen, additional, Rinaldo, Massimo, additional, D'Aiuto, Massimiliano, additional, Serraino, Diego, additional, Massarut, Samuele, additional, Caggiari, Laura, additional, Evangelista, Chiara, additional, Steffan, Agostino, additional, Catalano, Francesca, additional, Banna, Giuseppe L., additional, Scandurra, Giuseppa, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Antonelli, Giovanna, additional, Guerra, Gennaro, additional, Farina, Amalia, additional, Messina, Francesco, additional, Riccardi, Gabriele, additional, Gatti, Davide, additional, Jenkins, David J. A., additional, Celentano, Egidio, additional, Botti, Gerardo, additional, and Augustin, Livia S. A., additional

Published
2020
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9. Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial

Author

Porciello, Giuseppe, primary, Montagnese, Concetta, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, Libra, Massimo, additional, Vitale, Sara, additional, Palumbo, Elvira, additional, Pica, Rosa, additional, Calabrese, Ilaria, additional, Cubisino, Serena, additional, Falzone, Luca, additional, Poletto, Luigina, additional, Martinuzzo, Valentina, additional, Prete, Melania, additional, Esindi, Nadia, additional, Thomas, Guglielmo, additional, Cianniello, Daniela, additional, Pinto, Monica, additional, Laurentiis, Michelino De, additional, Pacilio, Carmen, additional, Rinaldo, Massimo, additional, D’Aiuto, Massimiliano, additional, Serraino, Diego, additional, Massarut, Samuele, additional, Evangelista, Chiara, additional, Steffan, Agostino, additional, Catalano, Francesca, additional, Banna, Giuseppe L., additional, Scandurra, Giuseppa, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Antonelli, Giovanna, additional, Guerra, Gennaro, additional, Farina, Amalia, additional, Messina, Francesco, additional, Riccardi, Gabriele, additional, Gatti, Davide, additional, Jenkins, David J. A., additional, Minopoli, Anita, additional, Grilli, Bruna, additional, Cavalcanti, Ernesta, additional, Celentano, Egidio, additional, Botti, Gerardo, additional, Montella, Maurizio, additional, and Augustin, Livia S. A., additional

Published
2020
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13. Radiofrequency ablation in patients with primary breast carcinoma

Author

Izzo, Francesco, Thomas, Renato, Delrio, Paolo, Rinaldo, Massimo, Vallone, Paolo, DeChiara, Anna, Botti, Gerardo, D'Auto, Giuseppe, Cortino, Pina, and Curley, Steven A.

Subjects
Ablation (Surgery) -- Evaluation, Radio waves -- Health aspects, Breast cancer -- Care and treatment, Tumors -- Radiotherapy, Health
Published
2001

14. Angiosarcoma of the breast, the unknown—a review of the current literature

Author

Esposito, Emanuela, primary, Avino, Franca, additional, di Giacomo, Raimondo, additional, Donzelli, Ivana, additional, Marone, Ugo, additional, Melucci, Maria Teresa, additional, Rinaldo, Chiara, additional, Ruffolo, Fulvio, additional, Saponara, Ruggero, additional, Siani, Claudio, additional, Tortoriello, Raffaele, additional, Botti, Gerardo, additional, Rinaldo, Massimo, additional, and Fucito, Alfredo, additional

Published
2019
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15. Intracystic papillary breast carcinoma with DCIS in a man: a case report

Author

Esposito, Emanuela, primary, Di Bonito, Maurizio, additional, Iodice, Giovanni, additional, Avino, Franca, additional, Donzelli, Ivana, additional, Fucito, Alfredo, additional, Melucci, Maria Teresa, additional, Saponara, Ruggero, additional, Siani, Claudio, additional, Tortoriello, Raffaele, additional, Rinaldo, Massimo, additional, and di Giacomo, Raimondo, additional

Published
2019
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16. Effect of a low glycemic index Mediterranean diet on cardiovascular risk factors in women diagnosed with breast cancer: Preliminary data from DEDiCa study

Author

Calabrese, Ilaria, primary, Porciello, Giuseppe, additional, Montagnese, Concetta, additional, Vitale, Sara, additional, Palumbo, Elvira, additional, Cubisino, Serena, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, Pica, Rosita, additional, Marotta, Vincenzo, additional, Falzone, Luca, additional, Dainotta, Patrizia, additional, De Laurentis, Michele, additional, D'Aiuto, Massimiliano, additional, Rinaldo, Massimo, additional, Thomas, Guglielmo, additional, Catalano, Francesca, additional, Banna, Giuseppe, additional, Ursino, Vera, additional, Ferraù, Francesco, additional, Rossello, Rosalba, additional, Serraino, Diego, additional, Bidoli, Ettore, additional, Massarut, Samuele, additional, Barchiesi, Vittoria, additional, Minopoli, Anita, additional, Cuomo, Marco, additional, Cavalcanti, Ernesta, additional, Cianniello, Daniela, additional, Pacilio, Carmen, additional, Guerra, Gennaro, additional, Farina, Amalia, additional, Messina, Francesco, additional, Pinto, Monica, additional, Poletto, Luigina, additional, Cervo, Silvia, additional, D'Andrea, Monica, additional, Steffan, Agostino, additional, Riccardi, Gabriele, additional, Jenkins, David J A, additional, Gatti, Davide, additional, Libra, Massimo, additional, Montella, Maurizio, additional, and Augustin, Livia S A, additional

Published
2019
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17. Adherence to Mediterranean Diet and Quality of Life in women treated for breast cancer (DEDiCa Study)

Author

Porciello, Giuseppe, primary, Calabrese, Ilaria, additional, Montagnese, Concetta, additional, Vitale, Sara, additional, Palumbo, Elvira, additional, Cubisino, Serena, additional, Falzone, Luca, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, Libra, Massimo, additional, Pica, Rosita, additional, De Laurentis, Michele, additional, Cavalcanti, Ernesta, additional, D'Aiuto, Massimiliano, additional, Rinaldo, Massimo, additional, Catalano, Francesca, additional, Thomas, Guglielmo, additional, Cianniello, Daniela, additional, Pacilio, Carmen, additional, Barchiesi, Vittoria, additional, Minopoli, Anita, additional, Cuomo, Marco, additional, Banna, Giuseppe, additional, Vera, Ursino, additional, Ferrau, Francesco, additional, Rossello, Rosalba, additional, Serraino, Diego, additional, Bidoli, Ettore, additional, Massarut, Samuele, additional, Guerra, Gennaro, additional, Farina, Amalia, additional, Messina, Francesco, additional, Pinto, Monica, additional, Dainotta, Patrizia, additional, Poletto, Luigina, additional, Cervo, Silvia, additional, Gallina, Stefania, additional, Steffan, Agostino, additional, Gatti, Davide, additional, Riccardi, Gabriele, additional, Jenkins, David JA, additional, Augustin, Livia SA, additional, and Montella, Maurizio, additional

Published
2019
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18. Effects on quality of life of weekly docetaxel-based chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial

Author

Rinaldo Massimo, Thomas Renato, D'Aiuto Giuseppe, Piccirillo Maria, De Maio Ermelinda, Rossi Emanuela, Labonia Vincenzo, Pacilio Carmen, Landi Gabriella, Di Rella Francesca, Gravina Adriano, Morabito Alessandro, Nuzzo Francesco, Botti Gerardo, Di Bonito Maurizio, Di Maio Massimo, Gallo Ciro, Perrone Francesco, and de Matteis Andrea

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To evaluate whether weekly schedules of docetaxel-based chemotherapy were superior to 3-weekly ones in terms of quality of life in locally advanced or metastatic breast cancer. Methods Patients with locally advanced or metastatic breast cancer, aged ≤ 70 years, performance status 0-2, chemotherapy-naive for metastatic disease, were eligible. They were randomized to weekly or 3-weekly combination of docetaxel and epirubicin, if they were not treated with adjuvant anthracyclines, or docetaxel and capecitabine, if treated with adjuvant anthracyclines. Primary end-point was global quality of life change at 6-weeks, measured by EORTC QLQ-C30. With two-sided alpha 0.05 and 80% power for 35% effect size, 130 patients per arm were needed. Results From February 2004 to March 2008, 139 patients were randomized, 70 to weekly and 69 to 3-weekly arm; 129 and 89 patients filled baseline and 6-week questionnaires, respectively. Global quality of life was better in the 3-weekly arm (p = 0.03); patients treated with weekly schedules presented a significantly worsening in role functioning and financial scores (p = 0.02 and p < 0.001). Neutropenia and stomatitis were worse in the 3-weekly arm, where two toxic deaths were observed. Overall response rate was 39.1% and 33.3% in 3-weekly and weekly arms; hazard ratio of progression was 1.29 (95% CI: 0.84-1.97) and hazard ratio of death was 1.38 (95% CI: 0.82-2.30) in the weekly arm. Conclusions In this trial, the weekly schedules of docetaxel-based chemotherapy appear to be inferior to the 3-weekly one in terms of quality of life in patients with locally advanced or metastatic breast cancer. Trial registration ClinicalTrials.gov NCT00540800.

Published
2011
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19. Compliance and toxicity of adjuvant CMF in elderly breast cancer patients: a single-center experience

Author

Rinaldo Massimo, Capasso Immacolata, D'Aiuto Giuseppe, Rossi Emanuela, Nuzzo Francesco, Landi Gabriella, Labonia Vincenzo, Amabile Gerardo, Pacilio Carmen, Gravina Adriano, De Maio Ermelinda, Morrica Brunello, Elmo Massimo, Di Maio Massimo, Perrone Francesco, and de Matteis Andrea

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Few data are available on compliance and safety of adjuvant chemotherapy when indicated in elderly breast cancer patients; CMF (cyclophosphamide, methotrexate, fluorouracil) can be reasonably considered the most widely accepted standard of treatment. Methods We retrospectively reviewed compliance and safety of adjuvant CMF in patients older than 60. The treatment was indicated if patients had no severe comorbidity, a high-risk of recurrence, and were younger than 75. Toxicity was coded by NCI-CTC. Toxicity and compliance were compared between two age subgroups ( Results From March 1991 to March 2002, 180 patients were identified, 100 older than 60 and younger than 65, and 80 aged 65 or older. Febrile neutropenia was more frequent among older patients (p = 0.05). Leukopenia, neutropenia, nausea, cardiac toxicity and thrombophlebitis tended to be more frequent or severe among elderlies, while mucositis tended to be more evident among younger patients, all not significantly. Almost one half (47%) of the older patients receiving concomitant radiotherapy experienced grade 3–4 haematological toxicity. Compliance was similar in the two groups, with 6 cycles administered in 86% and 79%, day-8 chemotherapy omitted at least once in 36% and 39%, dose reduction in 27% and 38%, prolonged treatment duration (≥ 29 weeks) in 10% and 11% and need of G-CSF in 9% and 18%, among younger and older patients, respectively. Conclusion Our data show that, in a highly selected population of patients 65 or more years old, CMF is as feasible as in patients older than 60 and younger than 65, but with a relevant burden of toxicity. We suggest that prospective trials in elderly patients testing less toxic treatment schemes are mandatory before indicating adjuvant chemotherapy to all elderly patients with significant risk of breast cancer recurrence.

Published
2005
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21. Low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa): design of a clinical trial

Author

Augustin, Livia S.A., primary, Libra, Massimo, additional, Crispo, Anna, additional, Grimaldi, Maria, additional, De Laurentiis, Michele, additional, Rinaldo, Massimo, additional, D’Aiuto, Massimiliano, additional, Catalano, Francesca, additional, Banna, Giuseppe, additional, Ferrau’, Francesco, additional, Rossello, Rosalba, additional, Serraino, Diego, additional, Bidoli, Ettore, additional, Massarut, Samuele, additional, Thomas, Guglielmo, additional, Gatti, Davide, additional, Cavalcanti, Ernesta, additional, Pinto, Monica, additional, Riccardi, Gabriele, additional, Vidgen, Edward, additional, Kendall, Cyril W.C., additional, Jenkins, David J.A., additional, Ciliberto, Gennaro, additional, and Montella, Maurizio, additional

Published
2017
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23. Breast Contrast Enhanced MR Imaging: Semi-Automatic Detection of Vascular Map and Predominant Feeding Vessel

Author

Petrillo, Antonella, primary, Fusco, Roberta, additional, Filice, Salvatore, additional, Granata, Vincenza, additional, Catalano, Orlando, additional, Vallone, Paolo, additional, Di Bonito, Maurizio, additional, D’Aiuto, Massimiliano, additional, Rinaldo, Massimo, additional, Capasso, Immacolata, additional, and Sansone, Mario, additional

Published
2016
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27. Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series

Author

Crispo, Anna, primary, Barba, Maddalena, additional, D’Aiuto, Giuseppe, additional, De Laurentiis, Michelino, additional, Grimaldi, Maria, additional, Rinaldo, Massimo, additional, Caolo, Giuseppina, additional, D’Aiuto, Massimiliano, additional, Capasso, Immacolata, additional, Esposito, Emanuela, additional, Amore, Alfonso, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, and Montella, Maurizio, additional

Published
2013
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28. Can semi-quantitative evaluation of uncertain (type II) time-intensity curves improve diagnosis in breast DCE-MRI?

Author

Fusco, Roberta, primary, Filice, Salvatore, additional, Granata, Vincenza, additional, Mandato, Ylenia, additional, Porto, Annamaria, additional, D’Aiuto, Massimiliano, additional, Rinaldo, Massimo, additional, Bonito, Maurizio Di, additional, Sansone, Mario, additional, Sansone, Carlo, additional, Rotondo, Antonio, additional, and Petrillo, Antonella Petrillo, additional

Published
2013
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29. Effects on quality of life of weekly docetaxel-based chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial

Author

Nuzzo, Francesco, primary, Morabito, Alessandro, additional, Gravina, Adriano, additional, Di Rella, Francesca, additional, Landi, Gabriella, additional, Pacilio, Carmen, additional, Labonia, Vincenzo, additional, Rossi, Emanuela, additional, De Maio, Ermelinda, additional, Piccirillo, Maria Carmela, additional, D'Aiuto, Giuseppe, additional, Thomas, Renato, additional, Rinaldo, Massimo, additional, Botti, Gerardo, additional, Di Bonito, Maurizio, additional, Di Maio, Massimo, additional, Gallo, Ciro, additional, Perrone, Francesco, additional, and de Matteis, Andrea, additional

Published
2011
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30. Endocrine Effects of Adjuvant Letrozole + Triptorelin Compared With Tamoxifen + Triptorelin in Premenopausal Patients With Early Breast Cancer

Author

Rossi, Emanuela, primary, Morabito, Alessandro, additional, De Maio, Ermelinda, additional, Di Rella, Francesca, additional, Esposito, Giuseppe, additional, Gravina, Adriano, additional, Labonia, Vincenzo, additional, Landi, Gabriella, additional, Nuzzo, Francesco, additional, Pacilio, Carmen, additional, Piccirillo, Maria Carmela, additional, D'Aiuto, Giuseppe, additional, D'Aiuto, Massimiliano, additional, Rinaldo, Massimo, additional, Botti, Gerardo, additional, Gallo, Ciro, additional, Perrone, Francesco, additional, and de Matteis, Andrea, additional

Published
2008
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31. Compliance and toxicity of adjuvant CMF in elderly breast cancer patients: a single-center experience

Author

De Maio, Ermelinda, primary, Gravina, Adriano, additional, Pacilio, Carmen, additional, Amabile, Gerardo, additional, Labonia, Vincenzo, additional, Landi, Gabriella, additional, Nuzzo, Francesco, additional, Rossi, Emanuela, additional, D'Aiuto, Giuseppe, additional, Capasso, Immacolata, additional, Rinaldo, Massimo, additional, Morrica, Brunello, additional, Elmo, Massimo, additional, Di Maio, Massimo, additional, Perrone, Francesco, additional, and de Matteis, Andrea, additional

Published
2005
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32. Effects on quality of life of weekly docetaxelbased chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial.

Author

Nuzzo, Francesco, Morabito, Alessandro, Gravina, Adriano, Rella, Francesca Di, Landi, Gabriella, Pacilio, Carmen, Labonia, Vincenzo, Rossi, Emanuela, Maio, Ermelinda De, Piccirillo, Maria Carmela, D'Aiuto, Giuseppe, Thomas, Renato, Rinaldo, Massimo, Botti, Gerardo, Bonito, Maurizio Di, Maio, Massimo Di, Gallo, Ciro, Perrone, Francesco, and de Matteis, Andrea

Subjects
QUALITY of life, DOCETAXEL, DRUG therapy, BREAST cancer, ANTHRACYCLINES
Abstract

Background: To evaluate whether weekly schedules of docetaxel-based chemotherapy were superior to 3-weekly ones in terms of quality of life in locally advanced or metastatic breast cancer. Methods: Patients with locally advanced or metastatic breast cancer, aged ≤ 70 years, performance status 0-2, chemotherapy-naive for metastatic disease, were eligible. They were randomized to weekly or 3-weekly combination of docetaxel and epirubicin, if they were not treated with adjuvant anthracyclines, or docetaxel and capecitabine, if treated with adjuvant anthracyclines. Primary end-point was global quality of life change at 6- weeks, measured by EORTC QLQ-C30. With two-sided alpha 0.05 and 80% power for 35% effect size, 130 patients per arm were needed. Results: From February 2004 to March 2008, 139 patients were randomized, 70 to weekly and 69 to 3-weekly arm; 129 and 89 patients filled baseline and 6-week questionnaires, respectively. Global quality of life was better in the 3-weekly arm (p = 0.03); patients treated with weekly schedules presented a significantly worsening in role functioning and financial scores (p = 0.02 and p < 0.001). Neutropenia and stomatitis were worse in the 3-weekly arm, where two toxic deaths were observed. Overall response rate was 39.1% and 33.3% in 3-weekly and weekly arms; hazard ratio of progression was 1.29 (95% CI: 0.84-1.97) and hazard ratio of death was 1.38 (95% CI: 0.82-2.30) in the weekly arm. Conclusions: In this trial, the weekly schedules of docetaxel-based chemotherapy appear to be inferior to the 3- weekly one in terms of quality of life in patients with locally advanced or metastatic breast cancer. Trial registration: ClinicalTrials.gov NCT00540800. [ABSTRACT FROM AUTHOR]

Published
2011
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33. Low glycemic index diet, exercise and vitamin D to reduce breast cancer recurrence (DEDiCa): design of a clinical trial

Author

Maria Grazia Grimaldi, Gennaro Ciliberto, Monica Pinto, Anna Crispo, Davide Gatti, David J.A. Jenkins, Cyril W.C. Kendall, Massimo Libra, Guglielmo Thomas, Francesco Ferraù, Diego Serraino, Massimo Rinaldo, Michele De Laurentiis, Edward Vidgen, Livia S. A. Augustin, Samuele Massarut, Francesca Catalano, Ettore Bidoli, Rosalba Rossello, Massimiliano D’Aiuto, Gabriele Riccardi, Maurizio Montella, Ernesta Cavalcanti, Giuseppe Luigi Banna, Augustin, Livia S. A, Libra, Massimo, Crispo, Anna, Grimaldi, Maria, DE LAURENTIIS, Michelino, Rinaldo, Massimo, D'Aiuto, Massimiliano, Catalano, Francesca, Banna, Giuseppe, Ferrau', Francesco, Rossello, Rosalba, Serraino, Diego, Bidoli, Ettore, Massarut, Samuele, Thomas, Guglielmo, Gatti, Davide, Cavalcanti, Ernesta, Pinto, Monica, Riccardi, Gabriele, Vidgen, Edward, Kendall, Cyril W. C, Jenkins, David J. A, Ciliberto, Gennaro, and Montella, Maurizio

Subjects
Cancer Research, Mediterranean diet, Dietary glycemic index, Diabete, Diet, Mediterranean, Study Protocol, 0302 clinical medicine, Hyperinsulinemia, 030212 general & internal medicine, Breast cancer recurrence, Cardiovascular disease, Diabetes, Disease-free survival, Exercise, Risk factors, Vitamin D, Randomized Controlled Trials as Topic, 2. Zero hunger, Middle Aged, 3. Good health, Exercise Therapy, Glycemic index, Treatment Outcome, Oncology, Research Design, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, Diet therapy, Context (language use), Breast Neoplasms, 03 medical and health sciences, Breast cancer, Internal medicine, Diabetes mellitus, medicine, Vitamin D and neurology, Genetics, Humans, Aged, business.industry, Patient Selection, medicine.disease, Endocrinology, Glycemic Index, Risk factor, Neoplasm Recurrence, Local, business
Abstract

Background Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods produce lower post-prandial glucose and insulin responses and have been associated with lower BC risk. Moderate physical activity post-diagnosis reduces BC recurrence and mortality, partly explained by reduced insulin and estrogen levels. Vitamin D increases cell differentiation/apoptosis and high serum vitamin D levels improve BC survival. Yet no trial has evaluated the combined effect of a low GI diet, moderate physical activity and vitamin D supplementation on BC recurrence in the context of a Mediterranean lifestyle setting. Methods Women (30-74 yr) who had undergone surgery for primary histologically confirmed BC (stages I-III) within the previous 12 months, in cancer centres in Italy, will be randomized to follow, for a maximum of 33 months, either a high intensity treatment (HIT) composed of low GI diet + exercise + vitamin D (60 ng/mL serum concentration) or a lower intensity treatment (LITE) with general advice to follow a healthy diet and exercise pattern + vitamin D to avoid insufficiency. Both interventions are on a background of a Mediterranean diet. Considering a 20% recurrence rate within 3 years for BC cases and a predicted rate of 10% in the HIT group, with power of 80% and two-sided alpha of 0.05, the subject number required will be 506 (n = 253 in each arm). Clinic visits will be scheduled every 3 months. Dietary and exercise counselling and vitamin D supplements will be given at each clinic visit when blood samples, anthropometric measures and 7-day food records will be collected. Discussion DEDiCa study aims to reduce BC recurrence in women with BC using a lifestyle approach with additional vitamin D and to investigate possible cardio-metabolic benefits as well as epigenetic modifications according to lifestyle changes. Given the supporting evidence and safety of the components of our intervention we believe it is feasible and urgent to test it in cancer patients. Trial registration May 11, 2016; NCT02786875. EudraCT Number 2015-005147-14

Published
2017

34. Breast Contrast Enhanced MR Imaging: Semi-Automatic Detection of Vascular Map and Predominant Feeding Vessel

Author

Paolo Vallone, Massimiliano D’Aiuto, Orlando Catalano, Maurizio Di Bonito, Mario Sansone, Roberta Fusco, Immacolata Capasso, Vincenza Granata, Massimo Rinaldo, Antonella Petrillo, Salvatore Filice, Petrillo, Antonella, Fusco, Roberta, Filice, Salvatore, Granata, Vincenza, Catalano, Orlando, Vallone, Paolo, Di Bonito, Maurizio, D'Aiuto, Massimiliano, Rinaldo, Massimo, Capasso, Immacolata, and Sansone, Mario

Subjects
lcsh:Medicine, Pathology and Laboratory Medicine, 030218 nuclear medicine & medical imaging, Diagnostic Radiology, 0302 clinical medicine, Breast Tumors, Medicine and Health Sciences, Image Processing, Computer-Assisted, Breast, lcsh:Science, Multidisciplinary, medicine.diagnostic_test, Lateral thoracic artery, Radiology and Imaging, Ethics committee, Arteries, Middle Aged, Magnetic Resonance Imaging, Professions, Oncology, 030220 oncology & carcinogenesis, cardiovascular system, Female, Radiology, Anatomy, Algorithms, Research Article, Adult, medicine.medical_specialty, Imaging Techniques, Breast lesion, education, Breast Neoplasms, Internal thoracic artery, Research and Analysis Methods, 03 medical and health sciences, Young Adult, Breast cancer, Signs and Symptoms, Malignant Tumors, Diagnostic Medicine, medicine.artery, Radiologists, Breast Cancer, medicine, Cancer Detection and Diagnosis, Humans, Aged, Retrospective Studies, business.industry, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Magnetic resonance imaging, medicine.disease, Mr imaging, People and Places, Lesions, Cardiovascular Anatomy, Blood Vessels, lcsh:Q, Population Groupings, Semi automatic, business
Abstract

Purpose To obtain breast vascular map and to assess correlation between predominant feeding vessel and tumor location with a semi-automatic method compared to conventional radiologic reading. Methods 148 malignant and 75 benign breast lesions were included. All patients underwent bilateral MR imaging. Written informed consent was obtained from the patients before MRI. The local ethics committee granted approval for this study. Semi-automatic breast vascular map and predominant vessel detection was performed on MRI, for each patient. Semi-automatic detection (depending on grey levels threshold manually chosen by radiologist) was compared with results of two expert radiologists; inter-observer variability and reliability of semi-automatic approach were assessed. Results Anatomic analysis of breast lesions revealed that 20% of patients had masses in internal half, 50% in external half and the 30% in subareolar/central area. As regards the 44 tumors in internal half, based on radiologic consensus, 40 demonstrated a predominant feeding vessel (61% were supplied by internal thoracic vessels, 14% by lateral thoracic vessels, 16% by both thoracic vessels and 9% had no predominant feeding vessel—p

Published
2016

35. Integration of DCE-MRI and DW-MRI Quantitative Parameters for Breast Lesion Classification

Author

Maurizio Di Bonito, Antonella Petrillo, Daniela Maria Amato, Vincenza Granata, Massimo Rinaldo, Massimiliano D’Aiuto, Roberta Fusco, Orlando Catalano, Mario Sansone, Salvatore Filice, Immacolata Capasso, Fusco, Roberta, Sansone, Mario, Filice, Salvatore, Granata, Vincenza, Catalano, Orlando, Amato, Daniela Maria, Di Bonito, Maurizio, D'Aiuto, Massimiliano, Capasso, Immacolata, Rinaldo, Massimo, and Petrillo, Antonella

Subjects
Adult, Gadolinium DTPA, medicine.medical_specialty, Article Subject, Adolescent, Immunology and Microbiology (all), Radiography, Breast lesion, lcsh:Medicine, Contrast Media, Breast Neoplasms, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Diagnosis, Differential, Text mining, Image Interpretation, Computer-Assisted, medicine, Breast MRI, Humans, In patient, skin and connective tissue diseases, Histological examination, Biochemistry, Genetics and Molecular Biology (all), General Immunology and Microbiology, medicine.diagnostic_test, business.industry, lcsh:R, General Medicine, Middle Aged, Diffusion Magnetic Resonance Imaging, ROC Curve, Feature (computer vision), Female, Radiology, Differential diagnosis, business, Breast Neoplasm, Human, Research Article
Abstract

Objective. The purpose of our study was to evaluate the diagnostic value of an imaging protocol combining dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in patients with suspicious breast lesions.Materials and Methods. A total of 31 breast lesions (15 malignant and 16 benign proved by histological examination) in 26 female patients were included in this study. For both DCE-MRI and DW-MRI model free and model based parameters were computed pixel by pixel on manually segmented ROIs. Statistical procedures included conventional linear analysis and more advanced techniques for classification of lesions in benign and malignant.Results. Our findings indicated no strong correlation between DCE-MRI and DW-MRI parameters. Results of classification analysis show that combining of DCE parameters or DW-MRI parameter, in comparison of single feature, does not yield a dramatic improvement of sensitivity and specificity of the two techniques alone. The best performance was obtained considering a full combination of all features. Moreover, the classification results combining all features are dominated by DCE-MRI features alone.Conclusion. The combination of DWI and DCE-MRI does not show a potential to dramatically increase the sensitivity and specificity of breast MRI. DCE-MRI alone gave the same performance as in combination with DW-MRI.

Published
2014

36. Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series

Author

Massimo Rinaldo, Giuseppina Caolo, Gerardo Botti, Massimiliano D’Aiuto, Maddalena Barba, Maurizio Di Bonito, Emanuela Esposito, Maria Grimaldi, Michelino De Laurentiis, Anna Crispo, Maurizio Montella, Giuseppe D'Aiuto, Immacolata Capasso, Alfonso Amore, Crispo, Anna, Barba, Maddalena, D'Aiuto, Giuseppe, DE LAURENTIIS, Michelino, Grimaldi, Maria, Rinaldo, Massimo, Caolo, Giuseppina, D'Aiuto, Massimiliano, Capasso, Immacolata, Esposito, Emanuela, Amore, Alfonso, Di Bonito, Maurizio, Botti, Gerardo, and Montella, Maurizio

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, Pathology, Breast Neoplasms, Mode of detection, Statistics, Nonparametric, Breast cancer screening, Breast cancer, Surgical oncology, Antigens, Neoplasm, Internal medicine, Genetics, medicine, Biomarkers, Tumor, Humans, Mammography, Mass Screening, Survival outcomes, Lymph node, Mass screening, Survival analysis, Aged, medicine.diagnostic_test, Proportional hazards model, business.industry, Middle Aged, medicine.disease, Survival Analysis, Molecular categories, medicine.anatomical_structure, Screening, Female, Drug Screening Assays, Antitumor, Neoplasm Recurrence, Local, business, Breast Neoplasm, Research Article, Human
Abstract

Background Stage shift is widely considered a major determinant of the survival benefit conferred by breast cancer screening. However, factors and mechanisms underlying such a prognostic advantage need further clarification. We sought to compare the molecular characteristics of screen detected vs. symptomatic breast cancers and assess whether differences in tumour biology might translate into survival benefit. Methods In a clinical series of 448 women with operable breast cancer, the Kaplan-Meier method and the log-rank test were used to estimate the likelihood of cancer recurrence and death. The Cox proportional hazard model was used for the multivariate analyses including mode of detection, age at diagnosis, tumour size, and lymph node status. These same models were applied to subgroups defined by molecular subtypes. Results Screen detected breast cancers tended to show more favourable clinicopathological features and survival outcomes compared to symptomatic cancers. The luminal A subtype was more common in women with mammography detected tumours than in symptomatic patients (68.5 vs. 59.0%, p=0.04). Data analysis across categories of molecular subtypes revealed significantly longer disease free and overall survival for screen detected cancers with a luminal A subtype only (p=0.01 and 0.02, respectively). For women with a luminal A subtype, the independent prognostic role of mode of detection on recurrence was confirmed in Cox proportional hazard models (p=0.03). An independent role of modality of detection on survival was also suggested (p=0.05). Conclusions Molecular subtypes did not substantially explain the differences in survival outcomes between screened and symptomatic patients. However, our results suggest that molecular profiles might play a role in interpreting such differences at least partially. Further studies are warranted to reinterpret the efficacy of screening programmes in the light of tumour biology.

Published
2013

37. The role of CD44+/CD24-/low biomarker for screening, diagnosis and monitoring of breast cancer.

Author

Camerlingo R, Ferraro GA, De Francesco F, Romano M, Nicoletti G, Di Bonito M, Rinaldo M, D'Andrea F, and Pirozzi G

Subjects
Adult, Aged, Aged, 80 and over, Breast Neoplasms diagnosis, Carcinoma, Ductal, Breast diagnosis, Early Detection of Cancer, Female, Humans, Middle Aged, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, Tumor Cells, Cultured, Biomarkers, Tumor metabolism, Breast Neoplasms metabolism, CD24 Antigen metabolism, Carcinoma, Ductal, Breast metabolism, Hyaluronan Receptors metabolism
Abstract

Cancer stem cells (CSCs) have been defined as 'a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor'. The CSC hypothesis postulates that a small subpopulation of cancer cells drives tumor initiation, growth and metastasis. CSCs have been isolated from breast cancer using CD44+/CD24-/low phenotype. The purpose of the present study was to evaluate the expression of CD44+/CD24-/low in two diverse breast carcinomas (ductal and lobular), and to determine the correlation between expression of CD44+/CD24-/low, and clinicopathological characteristics starting from human fresh breast cancer specimens. We analyzed specimens from 57 patients using CD44 and CD24 markers by flow cytometry and immunohistochemistry and correlated the CD44+/CD24-/low phenotype with clinicopathological characteristics. Moreover, mammosphere formation was tested. In all specimens tested, CD44+/CD24-/low phenotype was detectable with mean percentage of 4.73% as confirmed also by immunohistochemical analyses. A significant statistical association was found among these phenotypic groups and age, grade G3, estrogen and progesterone receptor, Ki-67 as well as lymph node metastasis. No correlation was found for histological type. In conclusion, our data showed that CD44+/CD24-/low phenotype was found at a high frequency in tumors pT2, G3, pN3, positive for Ki-67, and negative for estrogen and progesterone receptors highlighting the hypothesis that CD44+/CD24-/low profile correlates with the more aggressive clinical-pathological features of the disease.

Published
2014
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38. Color-doppler using contrast medium in evaluating the response to neoadjuvant treatment in patients with locally advanced breast carcinoma.

Author

Vallone P, D'Angelo R, Filice S, Petrosino T, Rinaldo M, De Chiara A, and Gallipoli A

Subjects
Aged, Aged, 80 and over, Carcinoma diagnosis, Carcinoma pathology, Female, Humans, Image Processing, Computer-Assisted, Middle Aged, Neoadjuvant Therapy, Polysaccharides therapeutic use, Time Factors, Breast Neoplasms diagnosis, Breast Neoplasms drug therapy, Contrast Media pharmacology, Ultrasonography, Doppler, Color methods
Abstract

Background: The aim of our study was to assess the color-Doppler ultrasound (CDU) pattern in the analysis of neoadjuvant preoperative treatment of patients with locally advanced breast carcinoma, improvement after injection of contrast medium (Levovist) and possible correlations between morphological and vascular aspects of the neoplasm and postoperative histopathological findings., Materials and Methods: We studied 50 patients affected by locally advanced breast carcinoma (T3a e b-T4), using CDU before and after injection of Levovist, prior to and after neoadjuvant chemotherapeutic treatment., Results: The use of Levovist for ultrasound examinations prior to treatment revealed a higher number of vascular signals in 94% of the lesions compared to the basic color-Doppler examination; in only 3 cases (6%) were no modifications observed after injection of the contrast medium. This finding was also evident after neoadjuvant treatment, as a greater number of vessels in 28 lesions were observed, in addition to residual vascularization in 9 patients in whom the basic color-Doppler examination demonstrated substantial avascularity. Histopathology revealed that this method was more sensitive in disclosing the presence of active neoplastic tissue., Conclusion: Color-Doppler ultrasound is the first step in assessing the efficacy of neochemotherapeutic treatment in patients affected by locally advanced breast carcinoma. Levovist increases sensitivity and improves the diagnostic precision, thus allowing for a better image of the vessels, which is an important index of the biological activity of the neoplasm, compared to the basic color-Doppler examination.

Published
2005

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