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493 results on '"Rimola, Antoni"'

2. High expression of CD38, CD69, CD95 and CD154 biomarkers in cultured peripheral T lymphocytes correlates with an increased risk of acute rejection in liver allograft recipients

Author

Boix, Francisco, Millan, Olga, Segundo, David San, Mancebo, Esther, Rimola, Antoni, Fabrega, Emilio, Fortuna, Virginia, Mrowiec, Anna, Castro-Panete, Maria J., Peña, Jesus de la, Llorente, Santiago, Minguela, Alfredo, Bolarin, Jose M., Paz-Artal, Estela, Lopez-Hoyos, Marcos, Brunet, Mercé, and Muro, Manuel

Published
2016
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4. Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study

Author

Castells, Lluis, Rimola, Antoni, Manzardo, Christian, Valdivieso, Andrés, Montero, José Luis, Barcena, Rafael, Abradelo, Manuel, Xiol, Xavier, Aguilera, Victoria, Salcedo, Magdalena, Rodriguez, Manuel, Bernal, Carmen, Suarez, Francisco, Antela, Antonio, Olivares, Sergio, del Campo, Santos, Laguno, Montserrat, Fernandez, José R., de la Rosa, Gloria, Agüero, Fernando, Perez, Iñaki, González-García, Juan, Esteban-Mur, Juan I., and Miro, Jose M.

Published
2015
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6. The impact of the prevention strategies on the indirect effects of CMV infection in solid organ transplant recipients

Author

Roman, Antonio, Manito, Nicolás, Campistol, Josep Maria, Cuervas-Mons, Valentín, Almenar, Luis, Arias, Manuel, Casafont, Fernando, del Castillo, Domingo, Crespo-Leiro, María G., Delgado, Juan F., Herrero, J. Ignacio, Jara, Paloma, Morales, José M., Navarro, Mercedes, Oppenheimer, Federico, Prieto, Martín, Pulpón, Luis A., Rimola, Antoni, Serón, Daniel, and Ussetti, Piedad

Published
2014
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9. New concepts and best practices for management of pre- and post-transplantation cancer

Author

Campistol, Josep M., Cuervas-Mons, Valentín, Manito, Nicolás, Almenar, Luis, Arias, Manuel, Casafont, Fernando, del Castillo, Domingo, Crespo-Leiro, María G., Delgado, Juan F., Herrero, J. Ignacio, Jara, Paloma, Morales, José M., Navarro, Mercedes, Oppenheimer, Federico, Prieto, Martín, Pulpón, Luis A., Rimola, Antoni, Román, Antonio, Serón, Daniel, and Ussetti, Piedad

Published
2012
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13. High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation

Author

Boix-Giner, Francisco, Millan, Olga, San Segundo, David, Muñoz-Cacho, Pedro, Mancebo, Esther, Llorente, Santiago, Rafael-Valdivia, Lourdes, Rimola, Antoni, Fábrega, Emilio, Mrowiec, Anna, Allende, Luis, Minguela, Alfredo, Bolarín, Jose M., Paz-Artal, Estela, López-Hoyos, Marcos, Brunet, Mercé, and Muro, Manuel

Published
2016
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14. Human Immunodeficiency Virus Infection Does not Worsen Prognosis of Liver Transplantation for Hepatocellular Carcinoma

Author

Agüero, Fernando, Forner, Alejandro, Manzardo, Christian, Valdivieso, Andres, Blanes, Marino, Barcena, Rafael, Rafecas, Antoni, Castells, Lluis, Abradelo, Manuel, Torre-Cisneros, Julian, Gonzalez-Dieguez, Luisa, Salcedo, Magdalena, Serrano, Trinidad, Jimenez-Perez, Miguel, Herrero, Jose Ignacio, Gastaca, Mikel, Aguilera, Victoria, Fabregat, Juan, del Campo, Santos, Bilbao, Itxarone, Romero, Carlos Jimenez, Moreno, Asuncion, Rimola, Antoni, and Miro, Jose M.

Published
2016
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16. Intra graft expression of genes involved in iron homeostasis the development operational tolerance in human liver transplantation

Author

Bohne, Felix, Martinez-Llordella, Marc, Lozano, Juan-Jose, Miquel, Rosa, Benitez, Carlos, Londono, Maria-Carlota, Manzia, Tommaso-Maria, Angelico, Roberta, Swinkels, Dorine W., Tjalsma, Harold, Lopez, Marta, Abraldes, Juan G., Bonaccorsi-Riani, Eliano, Jaeckel, Elmar, Taubert, Richard, Pirenne, Jacques, Rimola, Antoni, Tisone, Giuseppe, and Sanchez-Fueyo, Alberto

Subjects
Research, Health aspects, Homeostasis -- Research, Liver transplantation -- Health aspects -- Research, Gene expression -- Health aspects -- Research, Liver -- Transplantation
Abstract

Introduction In human solid organ transplantation, long-term graft survival requires the administration of lifelong immunosuppressive therapy. This may result in severe side effects and increased recipient morbidity and mortality. Over [...], Following organ transplantation, lifelong immunosuppressive therapy is required to prevent the host immune system from destroying the allograft. This can cause severe side effects and increased recipient morbidity and mortality. Complete cessation of immunosuppressive drugs has been successfully accomplished in selected transplant recipients, providing proof of principle that operational allograft tolerance is attainable in clinical transplantation. The intra graft molecular pathways associated with successful drug withdrawal, however, are not well defined. In this study, we analyzed sequential blood and liver tissue samples collected from liver transplant recipients enrolled in a prospective multicenter immunosuppressive drug withdrawal clinical trial. Before initiation of drug withdrawal, operationally tolerant and non tolerant recipients differed in the intra graft expression of genes involved in the regulation of iron homeostasis. Furthermore, as compared with nontole rant recipients, operationally tolerant patients exhibited higher serum levels of hepcidin and ferritin and increased hepatocyte iron deposition. Finally, liver tissue gene expression measurements accurately predicted the outcome of immunosuppressive withdrawal in an independent set of patients. These results point to a critical role for iron metabolism in the regulation of intra graft alloimmune responses in humans and provide a set of biomarkers to conduct drug weaning trials in liver transplantation.

Published
2012
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20. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients

Author

Martinez-Llordella, Marc, Lozano, Juan Jose, Puig-Pey, Isabel, Orlando, Giuseppe, Tisone, Giuseppe, Lerut, Jan, Benitez, Carlos, Pons, Jose Antonio, Parrilla, Pascual, Ramirez, Pablo, Bruguera, Miquel, Rimola, Antoni, and Sanchez-Fueyo, Alberto

Subjects
Immunosuppressive agents -- Dosage and administration, Organ transplant recipients -- Health aspects, Liver -- Transplantation, Liver -- Health aspects
Abstract

A fraction of liver transplant recipients are able to discontinue all immunosuppressive therapies without rejecting their grafts and are said to be operationally tolerant to the transplant. However, accurate identification of these recipients remains a challenge. To design a clinically applicable molecular test of operational tolerance in liver transplantation, we studied transcriptional patterns in the peripheral blood of 80 liver transplant recipients and 16 nontransplanted healthy individuals by employing oligonucleotide microarrays and quantitative real-time PCR. This resulted in the discovery and validation of several gene signatures comprising a modest number of genes capable of identifying tolerant and nontolerant recipients with high accuracy. Multiple peripheral blood lymphocyte subsets contributed to the tolerance-associated transcriptional patterns, although NK and [gamma][delta][TCR.sup.+] T cells exerted the predominant influence. These data suggest that transcriptional profiling of peripheral blood can be employed to identify liver transplant recipients who can discontinue immunosuppressive therapy and that innate immune cells are likely to play a major role in the maintenance of operational tolerance in liver transplantation., Introduction Maintenance of a normal allograft function despite complete discontinuation of all immunosuppressive drugs is occasionally reported in clinical organ transplantation, particularly following liver transplantation (1-9). Patients spontaneously accepting their [...]

Published
2008

21. MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation

Author

Londono, Maria-Carlota, Cardenas, Andres, Guevara, Monica, Quinto, Llorenc, Heras, Dara de las, Navasa, Miguel, Rimola, Antoni, Garcia-Valdecasas, Juan-Carlos, Arroyo, Vicente, and Gines, Pere

Subjects
Barcelona, Spain (City) -- Research, Liver cirrhosis -- Research, Liver cirrhosis -- Care and treatment, Liver cirrhosis -- Patient outcomes, Prognosis -- Research, Liver -- Transplantation, Liver -- Usage, Health
Published
2007

24. Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

Author

Benítez, Carlos, Londoño, María-Carlota, Miquel, Rosa, Manzia, Tommaso-Maria, Abraldes, Juan G., Lozano, Juan-José, Martínez-Llordella, Marc, López, Marta, Angelico, Roberta, Bohne, Felix, Sese, Pilar, Daoud, Frederic, Larcier, Patrick, Roelen, Dave L., Claas, Frans, Whitehouse, Gavin, Lerut, Jan, Pirenne, Jacques, Rimola, Antoni, Tisone, Giuseppe, and Sánchez-Fueyo, Alberto

Published
2013
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29. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation

Author

Bohne, Felix, Martínez-Llordella, Marc, Lozano, Juan-José, Miquel, Rosa, Benítez, Carlos, Londoño, María-Carlota, Manzia, Tommaso-María, Angelico, Roberta, Swinkels, Dorine W., Tjalsma, Harold, López, Marta, Abraldes, Juan G., Bonaccorsi-Riani, Eliano, Jaeckel, Elmar, Taubert, Richard, Pirenne, Jacques, Rimola, Antoni, Tisone, Giuseppe, and Sánchez-Fueyo, Alberto

Published
2012
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31. EUROPEAN LIVING DONOR PSYCHOSOCIAL FOLLOW-UP (ELIPSY PROJECT): RO-087

Author

Menjívar, Ana, Chloë, Ballesté, Yucetin, Lèvent, Dias, Leonídio, Legendre, Christophe, Hiesse, Christian, Kyriakides, George, Papachristou, Christina, Fehrman-Ekholm, Ingela, Kvarnström, Niclas, Söfteland, John, Paredes, David, Revuelta, Ignacio, Diekmann, Fritz, Peri, Josep Maria, Torres, Xavier, Martínez, Montserrat, Rimola, Antoni, Fondevila, Constantino, and Manyalich, Martí

Published
2011

38. Human immunodeficiency virus–infected liver transplant recipients with incidental hepatocellular carcinoma: A prospective multicenter nationwide cohort study

Author

Agüero, Fernando, Forner, Alejandro, Valdivieso, Andrés, Blanes, Marino, Barcena, Rafael, Manzardo, Christian, Rafecas, Antoni, Castells, Lluis, Abradelo, Manuel, Barrera-Baena, Pilar, González-Diéguez, Luisa, Salcedo, Magdalena, Serrano, Trinidad, Jiménez-Pérez, Miguel, Herrero, José Ignacio, Gastaca, Mikel, Aguilera, Victoria, Fabregat, Juan, Del Campo, Santos, Bilbao, Itxarone, Romero, Carlos Jiménez, Moreno, Asunción, Rimola, Antoni, Miro, José M, and FIPSE Investigators

Subjects
Adult, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, IMPACT, medicine.medical_treatment, Hepatitis C virus, HIV Infections, HEPATITIS-C, 030230 surgery, Liver transplantation, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, RECURRENCE, Cause of death, RISK, Transplantation, Hepatology, business.industry, Incidence (epidemiology), Liver Neoplasms, virus diseases, Middle Aged, medicine.disease, Liver Transplantation, TUMOR CHARACTERISTICS, Spain, Hepatocellular carcinoma, Cohort, SURVIVAL, Female, 030211 gastroenterology & hepatology, Surgery, EXPLANTS, business, Liver Failure, Cohort study
Abstract

There is a lack of data on incidental hepatocellular carcinoma (iHCC) in the setting of liver transplantation (LT) in human immunodeficiency virus (HIV)-infected patients. This study aims to describe the frequency, histopathological characteristics, and outcomes of HIV+ LT recipients with iHCC from a Spanish multicenter cohort in comparison with a matched cohort of LT patients without HIV infection. A total of 15 (6%) out of 271 patients with HIV infection who received LT in Spain from 2002 to 2012 and 38 (5%) out of the 811 HIV- counterparts presented iHCC in liver explants (P = 0.58). Patients with iHCC constitute the present study population. All patients also had hepatitis C virus (HCV)-related cirrhosis. There were no significant differences in histopathological features of iHCC between the 2 groups. Most patients showed a small number and size of tumoral nodules, and few patients had satellite nodules, microvascular invasion, or poorly differentiated tumors. After a median follow-up of 49 months, no patient developed hepatocellular carcinoma (HCC) recurrence after LT. HIV+ LT recipients tended to have lower survival than their HIV- counterparts at 1 (73% versus 92%), 3 (67% versus 84%), and 5 years (50% versus 80%; P = 0.06). There was also a trend to a higher frequency of HCV recurrence as a cause of death in the former (33% versus 10%; P = 0.097). In conclusion, among LT recipients for HCV-related cirrhosis, the incidence and histopathological features of iHCC in HIV+ and HIV- patients were similar. However, post-LT survival was lower in HIV+ patients probably because of a more aggressive HCV recurrence. Liver Transplantation 23 645-651 2017 AASLD.

Published
2017
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