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157 results on '"Rim, Hark"'

32. Relationship of serum bilirubin concentration to kidney function and 24-hour urine protein in Korean adults

Author

Jung Yeon Soon, Shin Ho Sik, and Rim Hark

Subjects
Proteinuria, Bilirubin, Glomerular filtration rate, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background The relationships among serum bilirubin concentration, kidney function and proteinuria have yet to be fully elucidated, nor have these relationships been investigated in Korean adults. Method We retrospectively reviewed the medical records of Korean adults who were evaluated at Kosin University Gospel Hospital (Busan, Republic of Korea) during a five-year period from January 2005 to December 2009. We evaluated the relationships among serum bilirubin concentration, estimated glomerular filtration rate (eGFR) and 24-hour urinary protein excretion in a sample of 1363 Korean adults aged 18 years or older. Results The values of eGFR 2 and 24-hour urine albumin ≥150 mg/day were observed in 26.1% (n = 356) and 40.5% (n = 553) of subjects, respectively. Fasting glucose levels ≥126 mg/dL were observed in 44.9% (n = 612) of the total sample. After adjustment for potential confounding factors including demographic characteristics, comorbidities and other laboratory measures, total serum bilirubin was positively associated with eGFR and negatively associated with proteinuria both in the whole cohort and in a subgroup of diabetic individuals. Conclusions To our knowledge, this is the first hospital-based study specifically aimed at examining the relationships among serum total bilirubin concentration, 24-hour urine protein and kidney function in Korean adults. We demonstrated that serum total bilirubin concentration was negatively correlated with 24-hour urine protein and positively correlated with eGFR in Korean non-diabetic and diabetic adults.

Published
2011
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33. The influence of chronic renal failure on the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis presenting as a positive urine culture

Author

Shin Ho, Jung Yeon, and Rim Hark

Subjects
Pyelonephritis, Chronic Renal Failure, Antimicrobial Susceptibility, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The role of chronic renal failure (CRF) in the antimicrobial resistance of uropathogens in patients with community-acquired acute pyelonephritis (APN) remains poorly understood. Method We performed a retrospective analysis of 502 adults (54 men, 448 women; mean age 61.7 ± 16.0 years, range 18-98 years) who were treated for community-acquired APN at Kosin University Gospel Hospital (Busan, Republic of Korea) during a ten-year period (January 2000 to December 2009). We evaluated the spectra and antimicrobial susceptibility profiles of uropathogens in CRF and non-CRF patients with community-acquired APN that presented as a positive urine culture. Results The 502 adult subjects were classified as either non-CRF APN patients (336 patients, 66.9%) or CRF APN patients (166 patients, 33.1%) according to their estimated glomerular filtration rate. No significant differences in the sensitivity of E. coli to a third cephalosporin, aminoglycoside (except gentamycin), or ciprofloxacin were observed between non-CRF and CRF patients. Conclusions In our series of patients with community-acquired APN that initially presented as a positive urine culture, CRF did not influence the isolation rates of different uropathogens or their patterns of susceptibility to antimicrobials.

Published
2011
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38. Uremic Encephalopathy with Basal Ganglia Lesions in a Diabetic Predialysis Patient

Author

Kim, Ye Na, Shin, Ho Sik, Jung, Yeon Soon, and Rim, Hark

Subjects
basal ganglia, Diabetes mellitus, uremic encephalopathy, predialysis
Abstract

Syndromes associated with acute bilateral lesions of the basal ganglia in diabetic uremic patients are uncommon, and usually have reversible clinical and imaging findings. Such syndromes are seen almost exclusively in patients with diabetes mellitus and renal failure. Previously reported cases have described diabetic men with uremia on dialysis. Here, we report a case of uremic encephalopathy with lesions of the basal ganglia in a diabetic predialysis patient. A 44-year-old man with uremic encephalopathy presented with dysarthria, chorea, and right upper extremity paresthesia. Magnetic resonance imaging of the brain showed classic findings of hyper intensity in the bilateral basal ganglia. The patient had no family history of psychiatric or neurological disease. Laboratory findings revealed elevated levels of blood urea nitrogen, creatinine, and glucose. Haloperidol and ropinirole therapy was continued, resulting in significant improvement without dialysis. The patient recovered from his episode without apparent sequelae.

Published
2013
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39. A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation

Author

Kim, Bo-Ra, Shin, Ho-Sik, Jung, Yeon-Soon, and Rim, Hark

Subjects
Kidney transplantation, Atrial premature complexes, Arrhythmias, cardiac, surgical procedures, operative, Tacrolimo, Transplante de rim, Complexos atriais prematuros, chemical and pharmacologic phenomena, Tachycardia, supraventricular, Arritimias cardiacas, Tacrolimus, Taquicardia supraventricular
Abstract

CONTEXT Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. CASE REPORT We report a case of a 53-year-old Asian female who developed various arrhythmic phenomena including atrial premature complexes and supraventricular tachycardia after administration of tacrolimus. CONCLUSION Tacrolimus-associated arrhythmia after kidney transplantation may be life-threatening, and so patients undergoing this procedure should be carefully monitored. CONTEXTO Tacrolimus (tacrolimo) é uma potente droga imunossupressora frequentemente administrada a pacientes receptores de transplante e exibe uma variedade de efeitos cardiovasculares adversos. RELATO DE CASO Relatamos um caso de uma mulher asiática de 53 anos de idade que desenvolveu vários fenômenos de arritmias, incluindo complexos atriais prematuros e taquicardia supraventricular após a administração de tacrolimus. CONCLUSÃO Tacrolimus associado a arritmia após transplante de rim pode ser fatal, por isso, pacientes submetidos a esse procedimento devem ser cuidadosamente monitorados.

Published
2013

40. A case of tacrolimus-induced supraventricular arrhythmia after kidney transplantation

Author

Kim,Bo-Ra, Shin,Ho-Sik, Jung,Yeon-Soon, and Rim,Hark

Subjects
Kidney transplantation, Atrial premature complexes, Arrhythmias, cardiac, surgical procedures, operative, cardiovascular system, chemical and pharmacologic phenomena, cardiovascular diseases, Tachycardia, supraventricular, Tacrolimus
Abstract

CONTEXT Tacrolimus is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects. CASE REPORT We report a case of a 53-year-old Asian female who developed various arrhythmic phenomena including atrial premature complexes and supraventricular tachycardia after administration of tacrolimus. CONCLUSION Tacrolimus-associated arrhythmia after kidney transplantation may be life-threatening, and so patients undergoing this procedure should be carefully monitored.

Published
2013

41. Survival by Time of Day of Hemodialysis in Korean Patients: A Single Center Study

Author

Kim, Bo Ra, Park, Jin Hee, Shin, Ho Sik, Jung, Yeon Soon, and Rim, Hark

Subjects
morning shift hemodialysis, afternoon shift hemodialysis, End-stage renal disease, time of day
Abstract

Background: Patients with end-stage renal disease (ESRD) typically undergo hemodialysis (HD) during the morning or afternoon, with time of treatment generally based on space availability or patient preference. No studies have investigated variation in patient survival as a function of the time of day of dialysis in Korean HD patients. We investigated the association of patient HD treatment shift with continued survival, controlling for well-established HD-related mortality risk factors. Method: A 10-year (from January 1, 2001 to December 31, 2010) follow-up retrospective cohort study was conducted among 120 ESRD patients who underwent HD at Kosin University Gospel Hospital either during a morning shift (n = 60) or an afternoon shift (n = 60). A variable comparison was conducted using a Chi-square test and t-test for categorical and continuous variables, respectively. Life table analysis was used to compare survival rates in the two treatment groups. Results: The mean survival rate of the morning-shift HD patients and afternoon-shift HD patients were not statistically different (mean survival, 61.1 months vs. 48.2 months; P = 0.139). The unadjusted 5-year survival rate for patients on morning shift hemodialysis was 87.3% versus 86.4% for patients on afternoon shift hemodialysis (P = 0.704 by Wilcoxon test). Conclusions: The survival rates of morning-shift HD patients and afternoon-shift HD patients were not different. Results from this cohort study may warrant prospective observational studies and randomized clinical trials in Korean HD patients for whom the time of day at which HD is administered is systemically varied.

Published
2012
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42. Toll-like Receptors

Author

Shin, Ho Sik, Jung, Yeon Soon, and Rim, Hark

Subjects
adaptive immunity, Toll-like receptors, innate immunity
Abstract

Mammals sense pathogen invasion through pattern-recognition receptors (PRRs). A group of transmembrane proteins, Toll-like receptors (TLRs) are mainly expressed on antigen-presenting cells, such as macrophages or dendritic cells, and play critical roles as PRRs (1). TLR signaling activates antigen-presenting cells that provoke innate immunity and establish adaptive immunity. TLRs can be activated not only by invading pathogens but also by certain danger or stress-associated endogenous molecules leading to the induction of sterile inflammation. Activation of TLRs is a first line defense of the immune system, leading not only to the activation and recruitment of neutrophils and macrophages to sites of infection, but also to the enhancement of antimicrobial activity (2). Each TLR has common effects, such as inflammatory cytokine induction or upregulation of costimulatory molecule expression. However, TLRs also have specific functions, exemplified by type I IFN-inducing ability. These immunoadjuvant effects are critical in antimicrobial immunity and also involved in manifestations of autoimmunity (1). Therefore, understanding the molecular mechanisms of TLRs should facilitate the development of therapeutic solutions for allergy and autoimmune diseases.

Published
2012
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44. Outcomes of acute kidney injury patients with and without cancer

Author

Juwon, Lee, primary, Jang, Gookhwan, additional, Kim, Sunmin, additional, Kim, Dajung, additional, Lee, Jinwook, additional, Park, Hyunjoon, additional, Lee, Junyeob, additional, Kim, Sangbin, additional, Kim, Yunkyung, additional, Kim, Soo Young, additional, Yang, Joung Wook, additional, Gwoo, Sangeon, additional, Kim, Ye Na, additional, Shin, Ho Sik, additional, Jung, Yeonsoon, additional, and Rim, Hark, additional

Published
2015
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