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Your search keyword '"Riley, I. Rochelle"' showing total 8 results
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8 results on '"Riley, I. Rochelle"'

3. Transdermal Detection of MB-102 and Correlation to Meropenem Pharmacokinetics During Continuous Renal Replacement Therapy: In Vivo Results

Author

Dorshow, Richard B., primary, Johnson, James R., additional, Shieh, Jeng-Jong, additional, Riley, I. Rochelle, additional, Rogers, Thomas E., additional, Pino, Christopher J., additional, Johnston, Kimberly A., additional, Tang, Peter, additional, Nolin, Thomas D., additional, Humes, H. David, additional, and Goldstein, Stuart L., additional

Published
2023
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5. Novel Chiral High-Performance Liquid Chromatographic (HPLC) Determination of MB-102, A New Fluorescent Tracer Agent Enabling the Measurement of Point-of-Care Glomerular Filtration Rate.

Author

Shieh, Jeng-Jong, Riley, I. Rochelle, Rogers, Thomas E., and Dorshow, Richard B.

Subjects
*GLOMERULAR filtration rate, *HIGH performance liquid chromatography, *COUNTER-ions, *POINT-of-care testing, *FILTERS & filtration, *CHROMATOGRAPHIC analysis, *WATER filtration
Abstract

A new chiral chromatography method has been developed to determine the chiral purity of MB-102. This method employs exchange of counter ions with the MB-102 molecule. Chromatography conditions including column temperature and concentration of counter ions were evaluated and optimized. This method may be used to monitor process development during formulation manufacture, is amenable to large scale production, and is suitable for the determination of agent chirality for reporting in regulatory submissions. Manufactured clinical supplies of both the drug substance and the drug product using this technique have been shown to routinely yield 99.9+ % D, D enantiomer. This new method is shown to be precise, accurate, and robust. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Transdermal fluorescence detection of a dual fluorophore system for noninvasive point-of-care gastrointestinal permeability measurement

Author

Dorshow, Richard B., primary, Johnson, J. R., additional, Debreczeny, Martin P., additional, Riley, I. Rochelle, additional, Shieh, Jeng-Jong, additional, Rogers, Thomas E., additional, Hall-Moore, Carla, additional, Shaikh, Nurmohammad, additional, Rouggly-Nickless, L. Colleen, additional, and Tarr, Phillip I., additional

Published
2019
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