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2. Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study

Author

Hogan, Alexandra B., Wu, Sean L., Toor, Jaspreet, Olivera Mesa, Daniela, Doohan, Patrick, Watson, Oliver J., Winskill, Peter, Charles, Giovanni, Barnsley, Gregory, Riley, Eleanor M., Khoury, David S., Ferguson, Neil M., and Ghani, Azra C.

Subjects
Prevention, Usage, Disease transmission -- Prevention, COVID-19 vaccines -- Usage, Secondary immunization -- Usage, COVID-19 -- Prevention
Abstract

Author(s): Alexandra B. Hogan 1,2,*, Sean L. Wu 3, Jaspreet Toor 2, Daniela Olivera Mesa 2, Patrick Doohan 2, Oliver J. Watson 2,4, Peter Winskill 2, Giovanni Charles 2, Gregory [...], Background Vaccines have reduced severe disease and death from Coronavirus Disease 2019 (COVID-19). However, with evidence of waning efficacy coupled with continued evolution of the virus, health programmes need to evaluate the requirement for regular booster doses, considering their impact and cost-effectiveness in the face of ongoing transmission and substantial infection-induced immunity. Methods and findings We developed a combined immunological-transmission model parameterised with data on transmissibility, severity, and vaccine effectiveness. We simulated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission and vaccine rollout in characteristic global settings with different population age-structures, contact patterns, health system capacities, prior transmission, and vaccine uptake. We quantified the impact of future vaccine booster dose strategies with both ancestral and variant-adapted vaccine products, while considering the potential future emergence of new variants with modified transmission, immune escape, and severity properties. We found that regular boosting of the oldest age group (75+) is an efficient strategy, although large numbers of hospitalisations and deaths could be averted by extending vaccination to younger age groups. In countries with low vaccine coverage and high infection-derived immunity, boosting older at-risk groups was more effective than continuing primary vaccination into younger ages in our model. Our study is limited by uncertainty in key parameters, including the long-term durability of vaccine and infection-induced immunity as well as uncertainty in the future evolution of the virus. Conclusions Our modelling suggests that regular boosting of the high-risk population remains an important tool to reduce morbidity and mortality from current and future SARS-CoV-2 variants. Our results suggest that focusing vaccination in the highest-risk cohorts will be the most efficient (and hence cost-effective) strategy to reduce morbidity and mortality.

Published
2023
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4. Ebola virus glycoprotein stimulates IL-18-dependent natural killer cell responses

Author

Wagstaffe, Helen R., Clutterbuck, Elizabeth A., Bockstal, Viki, Stoop, Jeroen N., Luhn, Kerstin, Douoguih, Macaya, Shukarev, Georgi, Snape, Matthew D., Pollard, Andrew J., Riley, Eleanor M., and Goodier, Martin R.

Subjects
Becton, Dickinson and Co., United Kingdom. National Institute for Health Research -- Analysis, Prevention, Analysis, Health aspects, Medical research -- Analysis -- Health aspects, Adenoviruses -- Health aspects -- Analysis, Vaccines -- Health aspects -- Analysis, Killer cells -- Analysis -- Health aspects, Cytokines -- Health aspects -- Analysis, Marburg virus disease -- Prevention, Ebola virus -- Health aspects -- Analysis, Medical equipment industry -- Health aspects -- Analysis, Virus diseases -- Prevention, Infection -- Prevention, Vaccination -- Health aspects -- Analysis, Antibodies -- Analysis -- Health aspects, Immune response -- Health aspects -- Analysis, T cells -- Health aspects -- Analysis
Abstract

Introduction Ebola virus infection causes a rapid-onset severe acute hemorrhagic fever (Ebola virus disease, EVD) with mortality ranging from 25% to 90% depending on the outbreak (1). Clinical development of [...], BACKGROUND. NK cells are activated by innate cytokines and viral ligands to kill virus-infected cells. These functions are enhanced during secondary immune responses and after vaccination by synergy with effector T cells and virus-specific antibodies. In human Ebola virus infection, clinical outcome is strongly associated with the initial innate cytokine response, but the role of NK cells has not been thoroughly examined. METHODS. The novel 2-dose heterologous Adenovirus type 26.ZEBOV (Ad26.ZEBOV) and modified vaccinia Ankara-BN-Filo (MVA-BN-Filo) vaccine regimen is safe and provides specific immunity against Ebola glycoprotein, and is currently in phase 2 and 3 studies. Here, we analyzed NK cell phenotype and function in response to Ad26.ZEBOV, MVA-BN-Filo vaccination regimen and in response to in vitro Ebola glycoprotein stimulation of PBMCs isolated before and after vaccination. RESULTS. We show enhanced NK cell proliferation and activation after vaccination compared with baseline. Ebola glycoprotein-induced activation of NK cells was dependent on accessory cells and TLR-4-dependent innate cytokine secretion (predominantly from [CD14.sup.+] monocytes) and enriched within less differentiated NK cell subsets. Optimal NK cell responses were dependent on IL-18 and IL-12, whereas IFN-[gamma] secretion was restricted by high concentrations of IL-10. CONCLUSION. This study demonstrates the induction of NK cell effector functions early after Ad26.ZEBOV, MVA-BN-Filo vaccination and provides a mechanism for the activation and regulation of NK cells by Ebola glycoprotein. TRIAL REGISTRATION. ClinicalTrials.gov NCT02313077. FUNDING. United Kingdom Medical Research Council Studentship in Vaccine Research, Innovative Medicines Initiative 2 Joint Undertaking, EBOVAC (grant 115861) and Crucell Holland (now Janssen Vaccines and Prevention B.V.), European Union's Horizon 2020 research and innovation programme and European Federation of Pharmaceutical Industries and Associations (EFPIA).

Published
2020
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6. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Band, Gavin, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Clarke, Geraldine, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, deVries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hubbart, Christina, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jeffreys, Anna, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Le, Si, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Ly, Alioune, Macharia, Alexander, MacInnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Kevin, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, McCreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Peshu, Norbert, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Rowlands, Kate, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, SanJoaquin, Miguel, Sepúlveda, Nuno, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Uyoga, Sophie, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, Ndila, Carolyne M, Macharia, Alexander W, Nyutu, Gideon, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Clark, Taane G, Kariuki, Silvia, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, and Williams, Thomas N

Published
2018
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10. Resistance to malaria through structural variation of red blood cell invasion receptors

Author

Malaria Genomic Epidemiology Network, Leffler, Ellen M., Band, Gavin, Busby, George B. J., Kivinen, Katja, Le, Quang Si, Clarke, Geraldine M., Bojang, Kalifa A., Conway, David J., Jallow, Muminatou, Sisay-Joof, Fatoumatta, Bougouma, Edith C., Mangano, Valentina D., Modiano, David, Sirima, Sodiomon B., Achidi, Eric, Apinjoh, Tobias O., Marsh, Kevin, Ndila, Carolyne M., Peshu, Norbert, Williams, Thomas N., Drakeley, Chris, Manjurano, Alphaxard, Reyburn, Hugh, Riley, Eleanor, Kachala, David, Molyneux, Malcolm, Nyirongo, Vysaul, Taylor, Terrie, Thornton, Nicole, Tilley, Louise, Grimsley, Shane, Drury, Eleanor, Stalker, Jim, Cornelius, Victoria, Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Rockett, Kirk A., Spencer, Chris C. A., and Kwiatkowski, Dominic P.

Published
2017

11. Author Correction: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

Author

Slater, Hannah C., Ross, Amanda, Felger, Ingrid, Hofmann, Natalie E., Robinson, Leanne, Cook, Jackie, Gonçalves, Bronner P., Björkman, Anders, Ouedraogo, Andre Lin, Morris, Ulrika, Msellem, Mwinyi, Koepfli, Cristian, Mueller, Ivo, Tadesse, Fitsum, Gadisa, Endalamaw, Das, Smita, Domingo, Gonzalo, Kapulu, Melissa, Midega, Janet, Owusu-Agyei, Seth, Nabet, Cécile, Piarroux, Renaud, Doumbo, Ogobara, Doumbo, Safiatou Niare, Koram, Kwadwo, Lucchi, Naomi, Udhayakumar, Venkatachalam, Mosha, Jacklin, Tiono, Alfred, Chandramohan, Daniel, Gosling, Roly, Mwingira, Felista, Sauerwein, Robert, Paul, Richard, Riley, Eleanor M, White, Nicholas J, Nosten, Francois, Imwong, Mallika, Bousema, Teun, Drakeley, Chris, and Okell, Lucy C

Published
2019
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13. Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

Author

White, Michael T, Verity, Robert, Griffin, Jamie T, Asante, Kwaku Poku, Owusu-Agyei, Seth, Greenwood, Brian, Drakeley, Chris, Gesase, Samwel, Lusingu, John, Ansong, Daniel, Adjei, Samuel, Agbenyega, Tsiri, Ogutu, Bernhards, Otieno, Lucas, Otieno, Walter, Agnandji, Selidji T, Lell, Bertrand, Kremsner, Peter, Hoffman, Irving, Martinson, Francis, Kamthunzu, Portia, Tinto, Halidou, Valea, Innocent, Sorgho, Hermann, Oneko, Martina, Otieno, Kephas, Hamel, Mary J, Salim, Nahya, Mtoro, Ali, Abdulla, Salim, Aide, Pedro, Sacarlal, Jahit, Aponte, John J, Njuguna, Patricia, Marsh, Kevin, Bejon, Philip, Riley, Eleanor M, and Ghani, Azra C

Published
2015
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14. The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus

Author

Cheynel, Louise, Lazarou, Luke, Riley, Eleanor M., and Viney, Mark

Abstract

Wild animals are under constant threat from a wide range of micro- and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti-parasite immune responses. Genetic polymorphism of immune-related loci contributes to inter-individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of single nucleotide polymorphisms (SNPs) in immune-related loci (the major histocompatibility complex [MHC], and loci coding for cytokines and Toll-like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine-coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). Our study provides a comprehensive view of how polymorphism of immune-related loci affects immune and infection phenotypes in naturally infected wild rodent populations.

Published
2023
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17. The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis

Author

Mousa, Andria, Al-Taiar, Abdullah, Anstey, Nicholas M., Badaut, Cyril, Barber, Bridget E., Bassat, Quique, Challenger, Joseph D., Cunnington, Aubrey J., Datta, Dibyadyuti, Drakeley, Chris, Ghani, Azra C., Gordeuk, Victor R., Grigg, Matthew J., Hugo, Pierre, John, Chandy C., Mayor, Alfredo, Migot-Nabias, Florence, Opoka, Robert O., Pasvol, Geoffrey, Rees, Claire, Reyburn, Hugh, Riley, Eleanor M., Shah, Binal N., Sitoe, Antonio, Sutherland, Colin J., Thuma, Philip E., Unger, Stefan A., Viwami, Firmine, Walther, Michael, Whitty, Christopher J. M., William, Timothy, and Okell, Lucy C.

Subjects
Quality management, Influence, Drug therapy, Development and progression, Patient outcomes, Patient care -- Quality management -- Influence -- Patient outcomes, Malaria -- Development and progression -- Drug therapy -- Patient outcomes
Abstract

Author(s): Andria Mousa 1,*, Abdullah Al-Taiar 2, Nicholas M. Anstey 3,4, Cyril Badaut 5,6, Bridget E. Barber 3,7, Quique Bassat 8,9,10,11,12, Joseph D. Challenger 1, Aubrey J. Cunnington 13, Dibyadyuti [...], Background Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as 'test-and-treat' policies administered by community health workers (CHWs). We conducted a pooled individual-participant meta-analysis to estimate the association between treatment delay and presenting with SM. Methods and findings A search using Ovid MEDLINE and Embase was initially conducted to identify studies on severe Plasmodium falciparum malaria that included information on treatment delay, such as fever duration (inception to 22nd September 2017). Studies identified included 5 case-control and 8 other observational clinical studies of SM and UM cases. Risk of bias was assessed using the Newcastle-Ottawa scale, and all studies were ranked as 'Good', scoring [greater than or equal to]7/10. Individual-patient data (IPD) were pooled from 13 studies of 3,989 (94.1% aged 3 to [less than or equal to]4 days versus [less than or equal to]24 hours: cerebral malaria [CM] = 2.42 [1.24-4.72], p = 0.01; respiratory distress syndrome [RDS] = 4.09 [1.70-9.82], p = 0.002). In addition to unmeasured confounding, which is commonly present in observational studies, a key limitation is that many severe cases and deaths occur outside healthcare facilities in endemic countries, where the effect of delayed or no treatment is difficult to quantify. Conclusions Our results quantify the relationship between rapid access to treatment and reduced risk of severe disease, which was particularly strong for SMA. There was some evidence to suggest that progression to other severe phenotypes may also be prevented by prompt treatment, though the association was not as strong, which may be explained by potential selection bias, sample size issues, or a difference in underlying pathology. These findings may help assess the impact of interventions that improve access to treatment.

Published
2020
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18. Long term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: a modelling study

Author

Hogan, Alexandra B, primary, Wu, Sean L, additional, Toor, Jaspreet, additional, Mesa, Daniela Olivera, additional, Doohan, Patrick, additional, Watson, Oliver J, additional, Winskill, Peter, additional, Charles, Giovanni, additional, Barnsley, Gregory, additional, Riley, Eleanor M, additional, Khoury, David S, additional, Ferguson, Neil M, additional, and Ghani, Azra C, additional

Published
2023
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19. Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach

Author

Hogan, Alexandra B, primary, Doohan, Patrick, additional, Wu, Sean L, additional, Mesa, Daniela Olivera, additional, Toor, Jaspreet, additional, Watson, Oliver J, additional, Winskill, Peter, additional, Charles, Giovanni, additional, Barnsley, Gregory, additional, Riley, Eleanor M, additional, Khoury, David S, additional, Ferguson, Neil M, additional, and Ghani, Azra C, additional

Published
2023
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23. The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density

Author

Slater, Hannah C., Ross, Amanda, Felger, Ingrid, Hofmann, Natalie E., Robinson, Leanne, Cook, Jackie, Gonçalves, Bronner P., Björkman, Anders, Ouedraogo, Andre Lin, Morris, Ulrika, Msellem, Mwinyi, Koepfli, Cristian, Mueller, Ivo, Tadesse, Fitsum, Gadisa, Endalamaw, Das, Smita, Domingo, Gonzalo, Kapulu, Melissa, Midega, Janet, Owusu-Agyei, Seth, Nabet, Cécile, Piarroux, Renaud, Doumbo, Ogobara, Doumbo, Safiatou Niare, Koram, Kwadwo, Lucchi, Naomi, Udhayakumar, Venkatachalam, Mosha, Jacklin, Tiono, Alfred, Chandramohan, Daniel, Gosling, Roly, Mwingira, Felista, Sauerwein, Robert, Paul, Richard, Riley, Eleanor M, White, Nicholas J, Nosten, Francois, Imwong, Mallika, Bousema, Teun, Drakeley, Chris, and Okell, Lucy C

Published
2019
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26. Intestinal inflammation and increased intestinal permeability in Plasmodium chabaudi AS infected mice

Author

Mooney, Jason P, primary, DonVito, Sophia M, additional, Lim, Rivka, additional, Keith, Marianne, additional, Pickles, Lia, additional, Maguire, Eleanor A, additional, Wagner-Gamble, Tara, additional, Oldfield, Thomas, additional, Bermejo Pariente, Ana, additional, Ehimiyein, Ajoke M, additional, Philbey, Adrian A, additional, Bottomley, Christian, additional, Riley, Eleanor M, additional, and Thompson, Joanne, additional

Published
2022
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31. Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01 E on Blood Stage Immunity in Young Children

Author

Bejon, Philip, Cook, Jackie, Bergmann-Leitner, Elke, Olotu, Ally, Lusingu, John, Mwacharo, Jedidah, Vekemans, Johan, Njuguna, Patricia, Leach, Amanda, Lievens, Marc, Dutta, Sheetij, von Seidlein, Lorenz, Savarese, Barbara, Villafana, Tonya, Lemnge, Martha M., Cohen, Joe, Marsh, Kevin, Corran, Patrick H., Angov, Evelina, Riley, Eleanor M., and Drakeley, Chris J.

Published
2011
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33. Identification of Hot Spots of Malaria Transmission for Targeted Malaria Control

Author

Bousema, Teun, Drakeley, Chris, Gesase, Samwel, Hashim, Ramadhan, Magesa, Stephen, Mosha, Frank, Otieno, Silas, Carneiro, Ilona, Cox, Jonathan, Msuya, Eliapendavyo, Kleinschmidt, Immo, Maxwell, Caroline, Greenwood, Brian, Riley, Eleanor, Sauerwein, Robert, Chandramohan, Daniel, and Gosling, Roly

Published
2010

35. Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5–17 months in Kenya and Tanzania: a randomised controlled trial

Author

Olotu, Ally, Lusingu, John, Leach, Amanda, Lievens, Marc, Vekemans, Johan, Msham, Salum, Lang, Trudie, Gould, Jayne, Dubois, Marie-Claude, Jongert, Erik, Vansadia, Preeti, Carter, Terrell, Njuguna, Patricia, Awuondo, Ken O, Malabeja, Anangisye, Abdul, Omar, Gesase, Samwel, Mturi, Neema, Drakeley, Chris J, Savarese, Barbara, Villafana, Tonya, Lapierre, Didier, Ballou, W Ripley, Cohen, Joe, Lemnge, Martha M, Peshu, Norbert, Marsh, Kevin, Riley, Eleanor M, von Seidlein, Lorenz, and Bejon, Philip

Published
2011
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37. Additional file 1 of Dry season prevalence of Plasmodium falciparum in asymptomatic Gambian children, with a comparative evaluation of diagnostic methods

Author

Mooney, Jason P., DonVito, Sophia M., Jahateh, Maimuna, Bittaye, Haddy, Bottomley, Christian, D’Alessandro, Umberto, and Riley, Eleanor M.

Abstract

Additional file 1: Fig. S1. Distribution of P. falciparum prevalence by village within clustered data. Related to Fig. 2. For villages which were clustered, parasite prevalence is shown for individual villages within each. Clusters were assigned to them by relative distance, as seen in each inset. The diameter of the pie chart is relative to the number of patients sampled, with detailed sampling numbers given in Table 2.

Published
2022
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44. ‘Bouncing Back’ From Subclinical Malaria: Inflammation and Erythrocytosis After Resolution of P. falciparum Infection in Gambian Children

Author

Mooney, Jason P., primary, DonVito, Sophia M., additional, Jahateh, Maimuna, additional, Bittaye, Haddy, additional, Keith, Marianne, additional, Galloway, Lauren J., additional, Ndow, Mortala, additional, Cunnington, Aubrey J., additional, D’Alessandro, Umberto, additional, Bottomley, Christian, additional, and Riley, Eleanor M., additional

Published
2022
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46. Long Term Vaccination Strategies to Mitigate the Global Impact of SARS-CoV-2 Transmission: A Modelling Study

Author

Hogan, Alexandra B., primary, Wu, Sean L., additional, Toor, Jaspreet, additional, Doohan, Patrick, additional, Watson, Oliver J., additional, Winskill, Peter, additional, Charles, Giovanni, additional, Barnsley, Gregory, additional, Riley, Eleanor M., additional, Khoury, David S., additional, Ferguson, Neil M., additional, and Ghani, Azra C., additional

Published
2022
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47. A novel locus of resistance to severe malaria in a region of ancient balancing selection

Author

Band, Gavin, Rockett, Kirk A., Spencer, Chris C.A., Kwiatkowski, Dominic P., Le, Quang Si, Clarke, Geraldine M., Kivinen, Katja, Leffler, Ellen M., Cornelius, Victoria, Conway, David J., Williams, Thomas N., Taylor, Terrie, Bojang, Kalifa A., Doumbo, Ogobara, Thera, Mahamadou A., Modiano, David, Sirima, Sodiomon B., Wilson, Michael D., Koram, Kwadwo A., Agbenyega, Tsiri, Achidi, Eric, Marsh, Kevin, Reyburn, Hugh, Drakeley, Chris, Riley, Eleanor, Molyneux, Malcolm, Jallow, Muminatou, Pinder, Margaret, Toure, Ousmane B., Konate, Salimata, Sissoko, Sibiri, Bougouma, Edith C., Mangano, Valentina D., Amenga-Etego, Lucas N., Ghansah, Anita K., Hodgson, Abraham V.O., Ansong, Daniel, Enimil, Anthony, Evans, Jennifer, Apinjoh, Tobias O., Macharia, Alexander, Ndila, Carolyne M., Newton, Charles, Peshu, Norbert, Uyoga, Sophie, Manjurano, Alphaxard, Kachala, David, Nyirongo, Vysaul, Mead, Daniel, Drury, Eleanor, Auburn, Sarah, Campino, Susana G., MacInnis, Bronwyn, Stalker, Jim, Gray, Emma, Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Mendy, Alieu, Craik, Rachel, Fitzpatrick, Kathryn, Molloy, Sile, Hart, Lee, Hutton, Robert, Kerasidou, Angeliki, and Johnson, Kimberly J.

Published
2015
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50. The London School of Hygiene and Tropical Medicine: a new century of malaria research

Author

Riley Eleanor M

Subjects
malaria, genetics, vaccines, drug combinations, economics, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

The global malaria situation has scarcely improved in the last 100 years, despite major advances in our knowledge of the basic biology, epidemiology and clinical basis of the disease. Effective malaria control, leading to a significant decrease in the morbidity and mortality attributable to malaria, will require a multidisciplinary approach. New tools - drugs, vaccine and insecticides - are needed but there is also much to be gained by better use of existing tools: using drugs in combination in order to slow the development of drug resistance; targeting resources to areas of greatest need; using geographic information systems to map the populations at risk and more sophisticated marketing techniques to distribute bed nets and insecticides. Sustainable malaria control may require the deployment of a highly effective vaccine, but there is much that can be done in the meantime to reduce the burden of disease.

Published
2000

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