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177 results on '"Rijsdijk, Frühling V."'

20. The association between body dysmorphic symptoms and suicidality among adolescents and young adults: a genetically informative study.

Author

Krebs, Georgina, Fernández de la Cruz, Lorena, Rijsdijk, Frühling V., Rautio, Daniel, Enander, Jesper, Rück, Christian, Lichtenstein, Paul, Lundström, Sebastian, Larsson, Henrik, Eley, Thalia C., and Mataix-Cols, David

Subjects
SELF-evaluation, BODY dysmorphic disorder, TWINS, SUICIDAL ideation, RISK assessment, SEVERITY of illness index, MENTAL depression, DESCRIPTIVE statistics, LOGISTIC regression analysis, ANXIETY, ADULTS, ADOLESCENCE
Abstract

Background: Previous research indicates that body dysmorphic disorder (BDD) is associated with risk of suicidality. However, studies have relied on small and/or specialist samples and largely focussed on adults, despite these difficulties commonly emerging in youth. Furthermore, the aetiology of the relationship remains unknown. Methods: Two independent twin samples were identified through the Child and Adolescent Twin Study in Sweden, at ages 18 (N = 6027) and 24 (N = 3454). Participants completed a self-report measure of BDD symptom severity. Young people and parents completed items assessing suicidal ideation/behaviours. Logistic regression models tested the association of suicidality outcomes with: (a) probable BDD, classified using an empirically derived cut-off; and (b) continuous scores of BDD symptoms. Bivariate genetic models examined the aetiology of the association between BDD symptoms and suicidality at both ages. Results: Suicidal ideation and behaviours were common among those with probable BDD at both ages. BDD symptoms, measured continuously, were linked with all aspects of suicidality, and associations generally remained significant after adjusting for depressive and anxiety symptoms. Genetic factors accounted for most of the covariance between BDD symptoms and suicidality (72.9 and 77.7% at ages 18 and 24, respectively), but with significant non-shared environmental influences (27.1 and 22.3% at ages 18 and 24, respectively). Conclusions: BDD symptoms are associated with a substantial risk of suicidal ideation and behaviours in late adolescence and early adulthood. This relationship is largely explained by common genetic liability, but non-shared environmental effects are also significant and could provide opportunities for prevention among those at high-risk. [ABSTRACT FROM AUTHOR]

Published
2022
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27. The association between body dysmorphic symptoms and suicidality among adolescents and young adults: a genetically informative study

Author

Krebs, Georgina, primary, Fernández de la Cruz, Lorena, additional, Rijsdijk, Frühling V., additional, Rautio, Daniel, additional, Enander, Jesper, additional, Rück, Christian, additional, Lichtenstein, Paul, additional, Lundström, Sebastian, additional, Larsson, Henrik, additional, Eley, Thalia C., additional, and Mataix-Cols, David, additional

Published
2020
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32. The relationship between independent and dependent life events and depression symptoms in Sri Lanka: a twin and singleton study

Author

Zavos, Helena M. S., primary, Dalton, Bethan, additional, Jayaweera, Kaushalya, additional, Harber-Aschan, Lisa, additional, Pannala, Gayani, additional, Adikari, Anushka, additional, Hatch, Stephani L., additional, Siribaddana, Sisira, additional, Sumathipala, Athula, additional, Hotopf, Matthew, additional, and Rijsdijk, Frühling V., additional

Published
2019
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33. The narrow-sense and common single nucleotide polymorphism heritability of early repolarization

Author

Bastiaenen, Rachel, primary, Nolte, Ilja M., additional, Munroe, Patricia B., additional, Riese, Harriëtte, additional, Nelson, Christopher, additional, O'Connor, Henry, additional, Gang, Yi, additional, Warren, Helen R., additional, Cabrera, Claudia, additional, Reinhard, Wibke, additional, Hengstenberg, Christian, additional, Rijsdijk, Frühling V., additional, Spector, Tim, additional, Snieder, Harold, additional, Samani, Nilesh J., additional, Jamshidi, Yalda, additional, and Behr, Elijah R., additional

Published
2019
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35. Heritability of the limbic networks

Author

Budisavljevic, Sanja, Kawadler, Jamie M., Dell'Acqua, Flavio, Rijsdijk, Frühling V., Kane, Fergus, Picchioni, Marco, McGuire, Philip, Toulopoulou, Timothea, Georgiades, Anna, Kalidindi, Sridevi, Kravariti, Eugenia, Murray, Robin M., Murphy, Declan G., Craig, Michael C., Catani, Marco, University of St Andrews. School of Medicine, and University of St Andrews. Population and Behavioural Science Division

Subjects
Adult, Male, Inheritance Patterns, Twins, diffusion tractography, uncinate fasciculus, fornix, QH426 Genetics, heritability, behavioral disciplines and activities, E-NDAS, Heritability, Young Adult, Limbic system, Cingulum, limbic system, Uncinate fasciculus, Neural Pathways, Humans, Registries, cingulum, QH426, Cerebral Cortex, Diffusion tractography, Original Articles, Middle Aged, Diffusion Tensor Imaging, nervous system, RC0321, Female, Nerve Net, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, psychological phenomena and processes
Abstract

This work was supported by the MRC UK (grant number G0400061) as the AIMS (Autism Imaging Multicentre Study) with support from the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, King’s College London, and the Sackler Institute for Translational Neurodevelopment. Additional funding was provided by the European Autism Interventions—A Multicentre Study for Developing New Medications (EU-AIMS), which received support from the Innovative Medicines Initiative Joint Undertaking (grant agreement number 115300), including financial contributions from the EU Seventh Framework Programme (FP7/2007-2013), the European Federation of Pharmaceutical Industries and Associations companies in kind, Autism Speaks, NARSAD, The Stanley Foundation, Schizophrenia Research Trust and Psychiatry Research Trust. M.C. is the recipient of a Wellcome Trust Investigator Award (103759/Z/14/Z). Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum ('medial default-mode network'), the ventral cingulum and the fornix ('hippocampal-diencephalic-retrosplenial network') and the uncinate fasciculus ('temporo-amygdala-orbitofrontal network'). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing. Publisher PDF

Published
2016

36. Age-related differences and heritability of the perisylvian language networks

Author

Budisavljevic, Sanja, Dell’Acqua, Flavio, Rijsdijk, Frühling V., Kane, Fergus, Picchioni, Marco, McGuire, Philip, Toulopoulou, Timothea, Georgiades, Anna, Kalidindi, Sridevi, Kravariti, Eugenia, Murray, Robin, Murphy, Declan G., Craig, Michael C., and Catani, Marco

Subjects
Heritability, Lateralization, Arcuate fasciculus, Diffusion tensor tractography, Network asymmetry, Language
Abstract

Acquisition of language skills depends on the progressive maturation of specialized brain networks that are usually lateralized in adult population. However, how genetic and environmental factors relate to the age-related differences in lateralization of these language pathways is still not known. We recruited 101 healthy right-handed subjects aged 9–40 years to investigate age-related differences in the anatomy of perisylvian language pathways and 86 adult twins (52 monozygotic and 34 dizygotic) to understand how heritability factors influence language anatomy. Diffusion tractography was used to dissect and extract indirect volume measures from the three segments of the arcuate fasciculus connecting Wernicke’s to Broca’s region (i.e., long segment), Broca’s to Geschwind’s region (i.e., anterior segment), and Wernicke’s to Geschwind’s region (i.e., posterior segment). We found that the long and anterior arcuate segments are lateralized before adolescence and their lateralization remains stable throughout adolescence and early adulthood. Conversely, the posterior segment shows right lateralization in childhood but becomes progressively bilateral during adolescence, driven by a reduction in volume in the right hemisphere. Analysisofthetwinsampleshowedthatgeneticandsharedenvironmentalfactorsinfluencetheanatomyofthosesegmentsthatlateralizeearlier, whereas specific environmental effects drive the variability in the volume of the posterior segment that continues to change in adolescence and adulthood.Ourresults suggest that the age-related differences in the lateralization of thelanguageperisylvianpathwaysare related to the relative contribution of genetic and environmental effects specific to each segment.

Published
2015

37. Heritability of the limbic networks

Author

Budisavljevic, Sanja, primary, Kawadler, Jamie M., additional, Dell'Acqua, Flavio, additional, Rijsdijk, Frühling V., additional, Kane, Fergus, additional, Picchioni, Marco, additional, McGuire, Philip, additional, Toulopoulou, Timothea, additional, Georgiades, Anna, additional, Kalidindi, Sridevi, additional, Kravariti, Eugenia, additional, Murray, Robin M., additional, Murphy, Declan G., additional, Craig, Michael C., additional, and Catani, Marco, additional

Published
2015
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38. Age-Related Differences and Heritability of the Perisylvian Language Networks

Author

Budisavljevic, Sanja, primary, Dell'Acqua, Flavio, additional, Rijsdijk, Frühling V., additional, Kane, Fergus, additional, Picchioni, Marco, additional, McGuire, Philip, additional, Toulopoulou, Timothea, additional, Georgiades, Anna, additional, Kalidindi, Sridevi, additional, Kravariti, Eugenia, additional, Murray, Robin M., additional, Murphy, Declan G., additional, Craig, Michael C., additional, and Catani, Marco, additional

Published
2015
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