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4. Effect of exercise after a deep venous thrombosis:A systematic review

Author

Rook, B., van Rijn, M. J.E., Jansma, E. P., van Montfrans, C., Rook, B., van Rijn, M. J.E., Jansma, E. P., and van Montfrans, C.

Abstract

Post-thrombotic syndrome (PTS) is a common complication after deep vein thrombosis (DVT) and has a major impact on physical symptoms, quality of life (QoL) and economic costs. Relatively simple lifestyle interventions as physical exercise might reduce PTS severity and increase QoL. To evaluate the direct and long-term effects of physical activity in patients with an acute or previous DVT. We conducted a systematic review through an additional search from 2007 up to March 2022, to complement the comprehensive systematic review of Kahn et al. Articles evaluating the effect of exercise after a DVT including symptoms, QoL and the incidence and severity of PTS, were included. Quality of the studies was assessed using a GRADE-like checklist and results were reported according to the PRISMA Statement. Ten studies were included, seven randomized controlled trials and three cohort studies. We identified three types of physical activity based on timing and duration; (1) early mobilisation in the acute phase of the DVT; (2) short duration exercise 1 year after DVT and (3) prolonged exercise during follow-up after a previous DVT. Early mobilisation showed improvement in QoL and pain reduction and after 2 years it resulted in a significant reduction of PTS severity. Prolonged supervised exercise resulted in improvement of QoL. In addition, positive effects on symptoms of venous insufficiency and muscle functions were observed. None of the included studies reported an increased risk of PTS or worsening of symptoms due to physical activity. Physical exercise after a DVT is safe, improves QoL, reduces pain and decreases PTS severity. Lifestyle intervention such as guided individualized training programs can be a useful supplementary therapy for patients after a DVT or for PTS patients. Optimal training programs may be identified by further studies that improve patient-oriented outcomes for both adults and children after a DVT.

Published
2024

8. Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling

Author

Beck, AH, Lee, C-H, Witten, DM, Gleason, BC, Edris, B, Espinosa, I, Zhu, S, Li, R, Montgomery, KD, Marinelli, RJ, Tibshirani, R, Hastie, T, Jablons, DM, Rubin, BP, Fletcher, CD, West, RB, and van de Rijn, M

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Human Genome, Biotechnology, Cancer, 2.1 Biological and endogenous factors, Aetiology, Biomarkers, Tumor, Comparative Genomic Hybridization, Gene Expression Profiling, Genomics, Humans, Immunohistochemistry, Leiomyosarcoma, Prognosis, Tissue Array Analysis, sarcoma, leiomyosarcoma, integrative genomics, gene expression profiling, array comparative genomic hybridization, tissue microarrays, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering showed three reproducible LMS clusters. Array comparative genomic hybridization (aCGH) was performed on 20 LMS samples and showed that the molecular subtypes defined by gene expression showed distinct genomic changes. Tumors from the 'muscle-enriched' cluster showed significantly increased copy number changes (P=0.04). A majority of the muscle-enriched cases showed loss at 16q24, which contains Fanconi anemia, complementation group A, known to have an important role in DNA repair, and loss at 1p36, which contains PRDM16, of which loss promotes muscle differentiation. Immunohistochemistry (IHC) was performed on LMS tissue microarrays (n=377) for five markers with high levels of messenger RNA in the muscle-enriched cluster (ACTG2, CASQ2, SLMAP, CFL2 and MYLK) and showed significantly correlated expression of the five proteins (all pairwise P

Published
2010

10. Effect of exercise after a deep venous thrombosis: A systematic review.

Author

Rook, B., van Rijn, M. J. E., Jansma, E. P., and van Montfrans, C.

Subjects
*VENOUS thrombosis, *VENOUS insufficiency, *POSTTHROMBOTIC syndrome, *PHYSICAL activity, *BREATHING exercises, *EXERCISE therapy, *POSITIVE pressure ventilation, *REDUCING exercises
Abstract

Post‐thrombotic syndrome (PTS) is a common complication after deep vein thrombosis (DVT) and has a major impact on physical symptoms, quality of life (QoL) and economic costs. Relatively simple lifestyle interventions as physical exercise might reduce PTS severity and increase QoL. To evaluate the direct and long‐term effects of physical activity in patients with an acute or previous DVT. We conducted a systematic review through an additional search from 2007 up to March 2022, to complement the comprehensive systematic review of Kahn et al. Articles evaluating the effect of exercise after a DVT including symptoms, QoL and the incidence and severity of PTS, were included. Quality of the studies was assessed using a GRADE‐like checklist and results were reported according to the PRISMA Statement. Ten studies were included, seven randomized controlled trials and three cohort studies. We identified three types of physical activity based on timing and duration; (1) early mobilisation in the acute phase of the DVT; (2) short duration exercise 1 year after DVT and (3) prolonged exercise during follow‐up after a previous DVT. Early mobilisation showed improvement in QoL and pain reduction and after 2 years it resulted in a significant reduction of PTS severity. Prolonged supervised exercise resulted in improvement of QoL. In addition, positive effects on symptoms of venous insufficiency and muscle functions were observed. None of the included studies reported an increased risk of PTS or worsening of symptoms due to physical activity. Physical exercise after a DVT is safe, improves QoL, reduces pain and decreases PTS severity. Lifestyle intervention such as guided individualized training programs can be a useful supplementary therapy for patients after a DVT or for PTS patients. Optimal training programs may be identified by further studies that improve patient‐oriented outcomes for both adults and children after a DVT. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study

Author

Alberga, Anna J., von Meijenfeldt, Gerdine C. I., Rastogi, Vinamr, de Bruin, Jorg L., Wever, Jan J., van Herwaarden, Joost A., Hamming, Jaap F., Hazenberg, Constantijn E. V. B., van Schaik, Jan, Mees, Barend M. E., van der Laan, Maarten J., Zeebregts, Clark J., Schurink, Geert W. H., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, A. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Fung Kon Jin, P. H. P., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. Khodadade, Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leij-Dekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. P. M., Lung, P. F. L., Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mat-Tens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijn-Dregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhui-Zen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., ten Raa, S., Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van't Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., te Slaa, A., Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Nolthenius, R. P. Tutein, Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen-van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., de Vries, B. M. Wallis, van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, VU University medical center, AII - Inflammatory diseases, APH - Digital Health, Medical Biochemistry, ACS - Diabetes & metabolism, AII - Infectious diseases, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
volume-outcome, complex AAA, endovascular, mortality
Abstract

Objective: We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR. Summary of Background Data: Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic aneurysms (complex AAs). It is unclear if a volumeoutcome association exists in endovascular treatment of complex AAs (complex EVAR). Methods: All patients prospectively registered in the Dutch Surgical Aneurysm Audit who underwent complex EVAR (FEVAR or BEVAR) between January 2016 and January 2020 were included. The effect of annual hospital volume on perioperative mortality was examined using multivariable logistic regression analyses. Patients were stratified into quartiles based on annual hospital volume to determine hospital volume categories. Results: We included 694 patients (539 FEVAR patients, 155 BEVAR patients). Perioperative mortality following FEVAR was 4.5% and 5.2% following BEVAR. Postoperative complication rates were 30.1% and 48.7%, respectively. The first quartile hospitals performed

Published
2023

12. Increase in invasive group A streptococcal (Streptococcus pyogenes) infections (iGAS) in young children in the Netherlands, 2022

Author

de Gier, Brechje, Marchal, Niek, de Beer-Schuurman, Ilse, te Wierik, Margreet, Hooiveld, Mariëtte, de Melker, Hester E., van Sorge, Nina M., Stuart, J. W. T. Cohen, Melles, D. C., van Dijk, K., Alzubaidy, A., Scholing, M., Kuil, S. D., Blaauw, G. J., Altorf-van der Kuil, W., Bierman, S. M., de Greeff, S. C., Groenendijk, S. R., Hertroys, R., Kuijper, E. J., Marchal, N., Monen, J. C. M., Notermans, D. W., Polman, J., van den Reek, W. J., Schneeberger-van der Linden, C., Schoffelen, A. F., Wielders, C. C. H., de Wit, B. J., Zoetigheid, R. E., van den Bijllaardt, W., Kraan, E. M., Haeseker, M. B., da Silva, J. M., de Jong, E., Maraha, B., van Griethuysen, A. J., Wintermans, B. B., van Trijp, M. J. C. A., Wong, M., Muller, A. E., Ott, A., Lokate, M., Bathoorn, E., Sinnige, J., Silvis, W., Renders, N. H., Bakker, L. J., Dorigo-Zetsma, J. W., Waar, K., van der Beek, M. T., Leversteijn-van Hall, M. A., van Mens, S. P., Schaftenaar, E., Nabuurs-Franssen, M. H., Maat, I., Diederen, B. M. W., Bode, L. G. M., Ong, D. S. Y., van Rijn, M., Dinant, S., Pontesilli, O., van Dam, D. W., de Brauwer, E. I. G. B., Bentvelsen, R. G., Buiting, A. G. M., Vlek, A. L. M., de Graaf, M., Troelstra, A., Jansz, A. R., van Meer, M. P. A., de Vries, J., Dos Santos, C. Oliveira, Rümke, Lidewij W., Vestjens, Stefan M. T., Vlaminckx, Bart J. M., Medical Microbiology and Infection Prevention, AII - Infectious diseases, APH - Global Health, APH - Methodology, APH - Quality of Care, Experimental Immunology, AII - Inflammatory diseases, APH - Aging & Later Life, and APH - Health Behaviors & Chronic Diseases

Subjects
Adult, Chickenpox, Streptococcus pyogenes, Child, Preschool, Streptococcal Infections/diagnosis, COVID-19, Humans, Netherlands/epidemiology, Child, Herpes Zoster, Pandemics
Abstract

In 2022, a sevenfold increase in the number of notifiable invasive Streptococcus pyogenes (iGAS) infections among children aged 0-5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years. Of 42 cases in this age group, seven had preceding or coinciding varicella zoster infections, nine were fatal. This increase is not attributable to a specific emm type. Vigilance for clinical deterioration as iGAS sign is warranted in young children, especially those with varicella zoster infection.

Published
2023

15. Third-generation cephalosporin resistant gram-negative bacteraemia in patients with haematological malignancy; an 11-year multi-centre retrospective study

Author

de la Court, Jara R., Woudt, Sjoukje H. S., Schoffelen, Annelot F., Heijmans, Jarom, de Jonge, Nick A., van der Bruggen, Tjomme, Bomers, Marije K., Lambregts, Merel M. C., Schade, Rogier P., Sigaloff, Kim C. E., Stuart, J. W. T. Cohen, Melles, D. C., van Dijk, K., Alzubaidy, A., Werdmuller, B. F. M., Blaauw, G. J., Diederen, B. M. W., Alblas, H. J., der Kuil, W. Altorf-van, Bierman, S. M., de Greeff, S. C., Groenendijk, S. R., Hertroys, R., Kuijper, E. J., Monen, J. C., Notermans, D. W., van den Reek, W. J., Smilde, A. E., Wielders, C. C. H., Zoetigheid, R. E., van den Bijllaardt, W., Kraan, E. M., Mattsson, E. E., da Silva, J. M., de Jong, E., Maraha, B., van Asselt, G. J., Demeulemeester, A., Wintermans, B. B., van Trijp, M., Ott, A., Sinnige, J., Silvis, W., Bakker, L. J., Dorigo-Zetsma, J. W., Waar, K., Bernards, A. T., Hall, M. A. Leversteijn-van, Schaftenaar, E., Nabuurs-Franssen, M. H., Wertheim, H., Bode, L., van Rijn, M., Dinant, S., Pontesilli, O., de Man, P., Wong, M., Muller, A. E., Renders, N. H., Bentvelsen, R. G., Buiting, A. G. M., Vlek, A. L. M., Stam, A. J., Troelstra, A., Overdevest, I. T. M. A., van Meer, M. P. A., dos Santos, C. Oliveira, Wolfhagen, M. J. H. M., Hematology, Internal medicine, AII - Infectious diseases, Medical Microbiology and Infection Prevention, APH - Quality of Care, Elderly care medicine, APH - Aging & Later Life, Graduate School, General Internal Medicine, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Clinical Haematology, Experimental Immunology, and APH - Health Behaviors & Chronic Diseases

Subjects
Third-generation-cephalosporin resistance, Colonization, Microbiology (medical), Febrile neutropenia, Bacteremia, General Medicine, Antimicrobial resistance, Empirical antibiotic therapy, Ceftazidime, Infectious Diseases, Carbapenems, Hematologic Neoplasms, Resistance surveillance, Humans, Prospective Studies, Retrospective Studies
Abstract

Objectives Among patients with haematological malignancy, bacteraemia is a common complication during chemotherapy-induced neutropenia. Resistance of gram-negative bacteria (GNB) to third-generation cephalosporins (3GC) is increasing. In order to explore the value of using surveillance cultures to guide empirical treatment e.g. choosing between carbapenem versus ceftazidime- we aimed to assess the distribution of pathogens causing bacteraemia in patients with haematological malignancy, and the proportion of 3GC-resistant GNB (3GC-R GNB) bacteraemia that was preceded by 3GC-R GNB colonization. Methods Using 11 years of data (2008–2018) from the Dutch national antimicrobial resistance surveillance system, we assessed the prevalence of 3GC-R GNB in episodes of bacteraemia, and the proportion of 3GC-R GNB bacteraemia that was preceded by 3GC-R GNB colonization. Colonization was defined as availability of any GNB surveillance isolate in the year before, independent of the causative micro-organism (time-paired isolates). Results We included 3887 patients, representing 4142 episodes of bacteraemia. GNB were identified in 715/4142 (17.3%), of which 221 (30.9%) were 3GC-R GNB. In 139 of these 221 patients a time-paired surveillance culture was available. In 76.2% (106/139) of patients these surveillance cultures already showed 3GC-R GNB isolates in the year prior to the culture date of the 3GC-R GNB positive blood isolate. Conclusions This multi-centre study shows that in patients with haematological malignancy, the majority of 3GC-R GNB bacteraemia is preceded by 3GC-R GNB colonization. Prospective clinical studies are needed to assess the safety and benefits of the use of surveillance-cultures to guide empirical therapy to restrict the empirical use of carbapenems in this population.

Published
2022

17. Self-care recommended by clinicians in patients with heart failure or type 2 diabetes: a Delphi study

Author

Westland, H, Van Rijn, M, Page, S, Wiebe, D, Freedland, K, Lee, C, Vellone, E, Aryal, S, Stromberg, A, Jaarsma, T, and Riegel, B

Subjects
Advanced and Specialized Nursing, Settore MED/45, Medical–Surgical Nursing, Cardiology and Cardiovascular Medicine
Abstract

Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Australian Catholic University, Australia Background Patients with heart failure or type 2 diabetes often experience bothersome symptoms (e.g., swelling, dizziness) and need clinical support with symptom management to reduce the impact of these symptoms. Knowledge about recommended self-care management behaviors by experienced clinicians can help to guide the development of more effective self-care interventions. Purpose To develop a list of common bothersome symptoms of heart failure and type 2 diabetes and of self-care management behaviors that clinicians recommend to patients to reduce the impact of these symptoms. Methods A two-round Delphi study among a panel of 37 nurses and physicians (heart failure only n=14; type 2 diabetes only n=11 and both heart failure and type 2 diabetes n=12) from Italy, the Netherlands, Sweden and the US was performed. Online surveys were used to identify common and bothersome symptoms and related self-care management behaviors that they recommend to patients with heart failure or type 2 diabetes. Self-care management behaviors that received at least 75% agreement were retained and similar self-care management behaviors were discussed and merged to reduce redundancy. Results For heart failure, the final list included 12 common bothersome symptoms (e.g., fatigue/tiredness, shortness of breath) and 51 related self-care management behaviors (e.g., balance rest & activity, check body weight & swelling). For type 2 diabetes, 11 common bothersome symptoms (e.g., hypo- and hyperglycemia symptom clusters, foot wounds) and 25 related self-care management behaviors (e.g., check blood sugar, take insulin, contact podiatrist) were included in the final list. Consensus was reached on the vast majority (70%) of recommended behaviors. Conclusion The lists of common bothersome symptoms and self-care management behaviors reflect consensus but also discrepancies between clinicians’ recommendations and current guidelines. Efforts to enhance and align the use of proven effective self-care management behaviors to reduce symptom impact in routine care by clinicians should be considered.

Published
2022

20. SARS-CoV-2 Risk Quantification Model and Validation Based on Large-Scale Dutch Test Events

Author

Kolen, B., Znidarsic, L., Voss, A., Donders, S., Kamphorst, I., Rijn, M van, Bonthuis, D., Clocquet, M., Schram, M., Scharloo, R., Boersma, T., Stobernack, T., Gelder, P. van, Kolen, B., Znidarsic, L., Voss, A., Donders, S., Kamphorst, I., Rijn, M van, Bonthuis, D., Clocquet, M., Schram, M., Scharloo, R., Boersma, T., Stobernack, T., and Gelder, P. van

Abstract

Contains fulltext : 252216.pdf (Publisher’s version ) (Open Access), In response to the outbreak of SARS-CoV-2, many governments decided in 2020 to impose lockdowns on societies. Although the package of measures that constitute such lockdowns differs between countries, it is a general rule that contact between people, especially in large groups of people, is avoided or prohibited. The main reasoning behind these measures is to prevent healthcare systems from becoming overloaded. As of 2021 vaccines against SARS-CoV-2 are available, but these do not guarantee 100% risk reduction and it will take a while for the world to reach a sufficient immune status. This raises the question of whether and under which conditions events like theater shows, conferences, professional sports events, concerts, and festivals can be organized. The current paper presents a COVID-19 risk quantification method for (large-scale) events. This method can be applied to events to define an alternative package of measures replacing generic social distancing.

Published
2022

23. Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study

Author

Alberga, Anna J., Karthaus, Eleonora G., Wilschut, Janneke A., de Bruin, Jorg L., Akkersdijk, George P., Geelkerken, Robert H., Hamming, Jaap F., Wever, Jan J., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. H. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, B. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Jin, P. H. P. F. K., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. H. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. K., Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leijdekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. H. P. M., Lung, P. F. Liqui, Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mattens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijndregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhuizen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., Raa, S. ten, Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van ’t Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., Slaa, A. te, Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R. P., Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen - van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., Wallis de Vries, B. M., van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., ACS - Microcirculation, Anesthesiology, Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, VU University medical center, ACS - Diabetes & metabolism, TechMed Centre, Multi-Modality Medical Imaging, Medical Biochemistry, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, Time Factors, Operative procedure, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Risk Assessment, Blood Vessel Prosthesis Implantation, Postoperative Complications, Risk Factors, Humans, Hospital Mortality, Prospective Studies, Registries, Treatment outcome, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Endovascular Procedures, Quality of care, Middle Aged, Endovascular procedure, Abdominal aortic aneurysm, Surgery, Female, Trends, Cardiology and Cardiovascular Medicine, Aortic Aneurysm, Abdominal
Abstract

Contains fulltext : 251573.pdf (Publisher’s version ) (Open Access) OBJECTIVE: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. METHODS: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outcome was peri-operative mortality trend per year, stratified by OSR and EVAR. Secondary outcomes were trends per year in major complications, textbook outcome (TbO), and characteristics of treated patients. The trends per year were evaluated and reported in odds ratios per year. RESULTS: In this study, 11 624 patients (74.8%) underwent EVAR and 3 908 patients (25.2%) underwent OSR. For EVAR, after adjustment for confounding factors, there was no improvement in peri-operative mortality (aOR [adjusted odds ratio] 1.06, 95% CI 0.94 - 1.20), while major complications decreased (2014: 10.1%, 2019: 7.0%; aOR 0.91, 95% CI 0.88 - 0.95) and the TbO rate increased (2014: 68.1%, 2019: 80.9%; aOR 1.13, 95% CI 1.10 - 1.16). For OSR, the peri-operative mortality decreased (2014: 6.1%, 2019: 4.6%; aOR 0.89, 95% CI 0.82 - 0.98), as well as major complications (2014: 28.6%, 2019: 23.3%; aOR 0.95, 95% CI 0.91 - 0.99). Furthermore, the proportion of TbO increased (2014: 49.1%, 2019: 58.3%; aOR 1.05, 95% CI 1.01 - 1.10). In both the EVAR and OSR group, the proportion of patients with cardiac comorbidity increased. CONCLUSION: Since the establishment of this nationwide quality improvement initiative (DSAA), all outcomes of iAAA repair following EVAR and OSR have improved, except for peri-operative mortality following EVAR which remained unchanged.

Published
2022

25. A genetic cluster of MDR Enterobacter cloacae complex ST78 harbouring a plasmid containing bla VIM-1 and mcr-9 in the Netherlands

Author

Hendrickx, Antoni P. A., Debast, Sylvia, Pérez-Vázquez, María, Schoffelen, Annelot F., Notermans, Daan W., Landman, Fabian, Wielders, Cornelia C. H., Cañada Garcia, Javier E., Flipse, Jacky, de Haan, Angela, Witteveen, Sandra, van Santen-Verheuvel, Marga, de Greeff, Sabine C., Kuijper, Ed, Schouls, Leo M., Maijer-Reuwer, A., Leversteijn-van Hall, M. A., Kluytmans, J. A. J. W., Spijkerman, I. J. B., van Dijk, K., Halaby, T., Zwart, B., Diederen, B. M. W., Voss, A., Dorigo-Zetsma, J. W., Ott, A., Oudbier, J. H., van der Vusse, M., Vlek, A. L. M., Buiting, A. G. M., Bode, L., Paltansing, S., van Griethuysen, A. J., den Reijer, M., van Trijp, M., van Elzakker, E. P. M., Muller, A. E., van der Linden, M. P. M., van Rijn, M., Wolfhagen, M. J. H. M., Waar, K., Kolwijck, E., Silvis, W., Schulin, T., Damen, M., Dinant, S., van Mens, S. P., Melles, D. C., Cohen Stuart, J. W. T., van Ogtrop, M. L., Overdevest, I. T. M. A., van Dam, A. P., Wertheim, H., Frénay, H. M. E., Sinnige, J. C., Mattsson, E. E., Bosboom, R. W., Stam, A., de Jong, E., Roescher, N., Heikens, E., Steingrover, R., Troelstra, A., Bathoorn, E., Trienekens, T. A. M., van Dam, D. W., de Brauwer, E. I. G. B., Stals, F. S., Government of Netherlands, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, Elderly care medicine, APH - Aging & Later Life, AII - Infectious diseases, Nursing, APH - Health Behaviors & Chronic Diseases, and Experimental Immunology

Subjects
0301 basic medicine, Carbapenem, biology, Brief Report, 030106 microbiology, Broth microdilution, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Meropenem, Microbiology, 03 medical and health sciences, 030104 developmental biology, Plasmid, AcademicSubjects/MED00290, Colistin, medicine, Multilocus sequence typing, AcademicSubjects/MED00740, AcademicSubjects/MED00230, Enterobacter cloacae, Etest, medicine.drug
Abstract

Background Carbapenemases produced by Enterobacterales are often encoded by genes on transferable plasmids and represent a major healthcare problem, especially if the plasmids contain additional antibiotic resistance genes. As part of Dutch national surveillance, 50 medical microbiological laboratories submit their Enterobacterales isolates suspected of carbapenemase production to the National Institute for Public Health and the Environment for characterization. All isolates for which carbapenemase production is confirmed are subjected to next-generation sequencing. Objectives To study the molecular characteristics of a genetic cluster of Enterobacter cloacae complex isolates collected in Dutch national surveillance in the period 2015–20 in the Netherlands. Methods Short- and long-read genome sequencing was used in combination with MLST and pan-genome MLST (pgMLST) analyses. Automated antimicrobial susceptibility testing (AST), the Etest for meropenem and the broth microdilution test for colistin were performed. The carbapenem inactivation method was used to assess carbapenemase production. Results pgMLST revealed that nine E. cloacae complex isolates from three different hospitals in the Netherlands differed by Conclusions The EclCluster-013 reported here represents an MDR E. cloacae complex ST78 strain containing an IncH12 plasmid carrying both the blaVIM-1 carbapenemase and the mcr-9 colistin resistance gene.

Published
2021

27. Community nurses’ perceptions on the use of advance care planning: a qualitative study

Author

Groenewegen, E.A., van Doorne, I (Thesis Advisor), van Rijn, M, Groenewegen, E.A., van Doorne, I (Thesis Advisor), and van Rijn, M

Abstract

Background: In order to meet the needs of patients, it is important that healthcare professionals know what these needs are. Advance care planning (ACP) is a method for recording those needs and preferences with the patient. ACP could decrease uncomfortable life-sustaining treatment and care transitions in the palliative phase, reduce stress and anxiety and increase the chance of dying at the preferred place. The frequency of ACP conversations remains low and is often conducted late in the disease trajectory. Community nurses seem suitable to carry out ACP because of their patient population and holistic vision, but research of ACP in community care is lacking. Insight in perceptions of community nurses could create potential improvements which can contribute to the feasibility of ACP. Objective: Explore perceptions of community nurses towards the use of ACP. Methods: A qualitative descriptive exploratory research design, in which bachelor degree nurses participated, was conducted. Thematic analysis was used to identify themes. Results: Fifteen community nurses from eight different home healthcare organisations were individually interviewed. Six themes were identified after analysis: nurses’ own beliefs towards ACP, time to start ACP, prerequisites for the use of ACP, collaboration between involved professionals in ACP, carrying out ACP and ACP as part of usual community care. Conclusion: Six themes regarding perceptions of community nurses on ACP were found: it is thought to be a tough topic, timing of ACP, the need for a trust-based therapeutic relationship, sufficient time, collaboration with other disciplines and too little awareness in home healthcare organisations with no available methods and tools. Community nurses are suitable to conduct ACP because they have time to carry out ACP and the opportunity to build a trust-based relationship with patients. Training and tools are necessary to support community nurses in ACP.

Published
2021

34. Plasmid diversity among genetically related Klebsiella pneumoniae bla KPC-2 and bla KPC-3 isolates collected in the Dutch national surveillance

Author

Hendrickx, APA, Landman, F, de Haan, A, Borst, D, Witteveen, S, van Santen-Verheuvel, MG, van der Heide, HGJ, Schouls, LM, Halaby, T, Steingrover, R, Stuart, JWTC, Melles, DC, Dijk, K, Spijkerman, IJB, Notermans, DW, Oudbier, JH, van Ogtrop, ML, Dam, A, den Reijer, M, Kluytmans, JAJW, van der Linden, MPG, Mattsson, EE, van der Vusse, M, Jong, EM, Maijer-Reuwer, A, van Trijp, M, van Griethuysen, AJ, Ott, A, Bathoorn, E, Sinnige, JC, Heikens, E, de Brauwer, EIGB, Stals, FS, Silvis, W, Dorigo-Zetsma, JW, Waar, K, van Mens, SP, Roescher, N, Voss, A, Wertheim, HFL, Slingerland, BCGC, Frenay, HME, Schulin, T, Diederen, BMW, Bode, Lonneke, Rijn, M, Dinant, S, Damen, M, de Man, P, Leversteijn-van Hall, MA, van Elzakker, EP, Muller, AE, Schneeberger, P, van Dam, DW, Buiting, AG, Vlek, ALM, Stam, A, Troelstra, A, Overdevest, ITMA, Bosboom, RW, Trienekens, TAM, Wolfhagen, MJ, Paltansing, S, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Surgery, Medical Microbiology & Infectious Diseases, Experimental Immunology, Nursing, APH - Aging & Later Life, and APH - Health Behaviors & Chronic Diseases

Subjects
0301 basic medicine, DNA, Bacterial, Klebsiella pneumoniae, 030106 microbiology, lcsh:Medicine, Virulence, Biology, Microbiology, Article, beta-Lactamases, 03 medical and health sciences, Plasmid, polycyclic compounds, Humans, Insertion sequence, lcsh:Science, Pathogen, Netherlands, Genetics, Multidisciplinary, Strain (biology), lcsh:R, High-Throughput Nucleotide Sequencing, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Resistome, Computational biology and bioinformatics, Klebsiella Infections, 030104 developmental biology, lcsh:Q, Plasmidome, Cation transport
Abstract

Carbapenemase-producingKlebsiella pneumoniaeemerged over the past decades as an important pathogen causing morbidity and mortality in hospitalized patients. For infection prevention and control, it is important to track the spread of bacterial strains in humans including the plasmids they contain. However, little is known concerning the plasmid repertoire amongK. pneumoniaestrains. Therefore, the major aim was to recapitulate the size, contents and diversity of the plasmids of genetically relatedK. pneumoniaestrains harboring the beta-lactamase geneblaKPC-2orblaKPC-3to determine their dissemination in the Netherlands and the former Dutch Caribbean islands from 2014-2019. Next-generation sequencing was combined with long-read third-generation sequencing to reconstruct 18 plasmids ofK. pneumoniae. wgMLST revealed five genetic clusters (termed KpnClusters) comprised ofK. pneumoniae blaKPC-2isolates and four clusters consisted ofblaKPC-3isolates. Each cluster was characterized by a distinct resistome and plasmidome. KpnCluster-019blaKPC-2isolates were found both in the Netherlands and the Caribbean islands.K. pneumoniae blaKPC-3isolates were found in the collection of the Netherlands. The 18 plasmids were mostly unrelated and varied betweenK. pneumoniae blaKPC-2andblaKPC-3clusters. However, the large and medium sized plasmids contained a variety of antibiotic resistance genes, transposons, insertion sequence elements, conjugal transfer systems, cation transport systems, toxin/antitoxin systems, and prophage-related sequence elements. The small plasmids carried genes implicated in virulence. Thus, implementing long-read plasmid sequencing analysis forK. pneumoniaesurveillance provided important insights in the success and understanding of transmission of a KpnCluster-019blaKPC-2strain between the Netherlands and the Caribbean.ImportanceCarbapenemase-producingKlebsiella pneumoniaehas spread globally and is of great concern for debilitated patients.K.pneumoniaeis notorious for spreading antimicrobial resistance genes by plasmids amongEnterobacterales. Combining short and long read sequencing enables reconstruction of plasmids containing antibiotic resistance genes, conjugation machinery, transposons, toxins and/or virulence determinants and thereby enhancing international pathogen surveillance.

Published
2020

35. Dietary practices in methylmalonic acidaemia: a European survey

Author

Pinto, A., Evans, S., Daly, A., Almeida, M.F., Assoun, M., Belanger-Quintana, A., Bernabei, S.M., Bollhalder, S., Cassiman, D., Champion, H., Chan, H., Corthouts, K., Dalmau, J., Boer, F. de, Laet, C. de, Meyer, A, Desloovere, A., Dianin, A., Dixon, M., Dokoupil, K., Dubois, S., Eyskens, F., Faria, A., Fasan, I., Favre, E., Feillet, F., Fekete, A., Gallo, G., Gingell, C., Gribben, J., Hansen, K.K., Horst, N.T., Jankowski, C., Janssen-Regelink, R.G., Jones, I., Jouault, C., Kahrs, G.E., Kok, I., Kowalik, A., Laguerre, C., Verge, S.L., Liguori, A., Lilje, R., Maddalon, C., Mayr, D., Meyer, U., Micciche, A., Och, U., Robert, M., Rocha, J.C., Rogozinski, H., Rohde, C., Ross, K., Saruggia, I., Schlune, A., Singleton, K., Sjoqvist, E., Skeath, R., Stolen, L.H., Terry, A., Timmer, C., Tomlinson, L., Tooke, A., Kerckhove, K.V., Dam, E. van, Hurk, D.V.D., Ploeg, L.V., Driessche, M. Van, Rijn, M. van de, Wegberg, A.M. van, Vasconcelos, C., Vestergaard, H., Vitoria, I., Webster, D., White, F., White, L., Zweers, H.E., MacDonald, A., Pinto, A., Evans, S., Daly, A., Almeida, M.F., Assoun, M., Belanger-Quintana, A., Bernabei, S.M., Bollhalder, S., Cassiman, D., Champion, H., Chan, H., Corthouts, K., Dalmau, J., Boer, F. de, Laet, C. de, Meyer, A, Desloovere, A., Dianin, A., Dixon, M., Dokoupil, K., Dubois, S., Eyskens, F., Faria, A., Fasan, I., Favre, E., Feillet, F., Fekete, A., Gallo, G., Gingell, C., Gribben, J., Hansen, K.K., Horst, N.T., Jankowski, C., Janssen-Regelink, R.G., Jones, I., Jouault, C., Kahrs, G.E., Kok, I., Kowalik, A., Laguerre, C., Verge, S.L., Liguori, A., Lilje, R., Maddalon, C., Mayr, D., Meyer, U., Micciche, A., Och, U., Robert, M., Rocha, J.C., Rogozinski, H., Rohde, C., Ross, K., Saruggia, I., Schlune, A., Singleton, K., Sjoqvist, E., Skeath, R., Stolen, L.H., Terry, A., Timmer, C., Tomlinson, L., Tooke, A., Kerckhove, K.V., Dam, E. van, Hurk, D.V.D., Ploeg, L.V., Driessche, M. Van, Rijn, M. van de, Wegberg, A.M. van, Vasconcelos, C., Vestergaard, H., Vitoria, I., Webster, D., White, F., White, L., Zweers, H.E., and MacDonald, A.

Abstract

Contains fulltext : 220058.pdf (Publisher’s version ) (Open Access), Background The dietary management of methylmalonic acidaemia (MMA) is a low-protein diet providing sufficient energy to avoid catabolism and to limit production of methylmalonic acid. The goal is to achieve normal growth, good nutritional status and the maintenance of metabolic stability. Aim To describe the dietary management of patients with MMA across Europe. Methods A cross-sectional questionnaire was sent to European colleagues managing inherited metabolic disorders (IMDs) (n=53) with 27 questions about the nutritional management of organic acidaemias. Data were analysed by different age ranges (0-6 months; 7-12 months; 1-10 years; 11-16 years; >16 years). Results Questionnaires were returned from 53 centres. Twenty-five centres cared for 80 patients with MMA vitamin B12 responsive (MMAB12r) and 43 centres managed 215 patients with MMA vitamin B12 non-responsive (MMAB12nr). For MMAB12r patients, 44% of centres (n=11/25) prescribed natural protein below the World Health Organization/Food and Agriculture Organization/United Nations University (WHO/FAO/UNU) 2007 safe levels of protein intake in at least one age range. Precursor-free amino acids (PFAA) were prescribed by 40% of centres (10/25) caring for 36% (29/80) of all the patients. For MMAB12nr patients, 72% of centres (n=31/43) prescribed natural protein below the safe levels of protein intake (WHO/FAO/UNU 2007) in at least one age range. PFAA were prescribed by 77% of centres (n=33/43) managing 81% (n=174/215) of patients. In MMAB12nr patients, 90 (42%) required tube feeding: 25 via a nasogastric tube and 65 via a gastrostomy. Conclusions A high percentage of centres used PFAA in MMA patients together with a protein prescription that provided less than the safe levels of natural protein intake. However, there was inconsistent practices across Europe. Long-term efficacy studies are needed to study patient outcome when using PFAA with different severities of natural protein restrictions in patients with MMA to

Published
2020

37. Plasmid diversity among genetically related Klebsiella pneumoniae bla KPC-2 and bla KPC-3 isolates collected in the Dutch national surveillance

Author

Hendrickx, A.P.A. (Antoni), Landman, F., Haan, A. (Alexander) de, Borst, D., Witteveen, S., Santen-Verheuvel, M. (Marga) van, van der Heide, H.G.J., Schouls, L.M., Halaby, T, Steingrover, R. (Radjin), Stuart, JWTC, Melles, D.C. (Damian), Dijk, K. (Korine) van, Spijkerman, I.J.B., Notermans, D.W. (Daan), Oudbier, J.H., van Ogtrop, M.L., van Dam, A., den Reijer, M., Kluytmans, JAJW, van der Linden, MPG, Mattsson, E.E., van der Vusse, M., Jong, E. (Eefje), Maijer-Reuwer, A., van Trijp, M., van Griethuysen, A.J., Ott, A. (Alewijn), Bathoorn, E., Sinnige, J.C., Heikens, E., Brauwer, E.I.G.B. (E. I G B) de, Stals, F.S. (Frans), Silvis, W., Dorigo-Zetsma, J.W., Waar, K., van Mens, S.P., Roescher, N., Voss, A. (Andreas), Wertheim, H.F.L. (Heiman), Slingerland, B.C.G.C. (Bibi), Frenay, H.M.E., Schülin, T. (Tanja), Diederen, BMW, Bode, L.G.M. (Lonneke), van Rijn, M., Dinant, S., Damen, M. (Mark), de Man, P., Leversteijn-van Hall, M.A., Elzakker, E. van, Muller, A.E., Schneeberger, P., van Dam, D.W., Buiting, AG, Vlek, ALM, Stam, A., Troelstra, A. (Annet), Overdevest, I.T.M.A., Bosboom, R.W., Trienekens, T.A.M., Wolfhagen, M.J., Paltansing, S, Hendrickx, A.P.A. (Antoni), Landman, F., Haan, A. (Alexander) de, Borst, D., Witteveen, S., Santen-Verheuvel, M. (Marga) van, van der Heide, H.G.J., Schouls, L.M., Halaby, T, Steingrover, R. (Radjin), Stuart, JWTC, Melles, D.C. (Damian), Dijk, K. (Korine) van, Spijkerman, I.J.B., Notermans, D.W. (Daan), Oudbier, J.H., van Ogtrop, M.L., van Dam, A., den Reijer, M., Kluytmans, JAJW, van der Linden, MPG, Mattsson, E.E., van der Vusse, M., Jong, E. (Eefje), Maijer-Reuwer, A., van Trijp, M., van Griethuysen, A.J., Ott, A. (Alewijn), Bathoorn, E., Sinnige, J.C., Heikens, E., Brauwer, E.I.G.B. (E. I G B) de, Stals, F.S. (Frans), Silvis, W., Dorigo-Zetsma, J.W., Waar, K., van Mens, S.P., Roescher, N., Voss, A. (Andreas), Wertheim, H.F.L. (Heiman), Slingerland, B.C.G.C. (Bibi), Frenay, H.M.E., Schülin, T. (Tanja), Diederen, BMW, Bode, L.G.M. (Lonneke), van Rijn, M., Dinant, S., Damen, M. (Mark), de Man, P., Leversteijn-van Hall, M.A., Elzakker, E. van, Muller, A.E., Schneeberger, P., van Dam, D.W., Buiting, AG, Vlek, ALM, Stam, A., Troelstra, A. (Annet), Overdevest, I.T.M.A., Bosboom, R.W., Trienekens, T.A.M., Wolfhagen, M.J., and Paltansing, S

Published
2020
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38. Molecular characteristics of carbapenemase-producing Enterobacterales in the Netherlands; results of the 2014–2018 national laboratory surveillance

Author

Zwaluw, K. (Kim) van der, Witteveen, S. (S.), Wielders, L. (L.), van Santen, M. (M.), Landman, F. (F.), de Haan, A. (A.), Schouls, L.M., Bosch, T. (T.), Cohen Stuart, J.W.T. (James), Melles, D.C. (Damian), Dijk, K.D. (Karin) van, Visser, C.E., Notermans, D.W. (Daan), Ogtrop, M.L. van, Werdmuller, B.F.M. (B. F.M.), Hees, B.C. (Babette) van, Kluytmans, J.A.J.W. (Jan), van den Bijllaardt, W. (Wouter), Kraan, E.M. (E. M.), van der Linden, M.P.M. (M. P.M.), Mattsson, E.E. (E. E.), Sebens, F. (Fré), de Jong, E. (E.), Frénay, H.M.E. (H. M.E.), Maraha, B. (B.), Griethuysen, A. (Arjanne) van, van Asselt, G.J. (G. J.), Demeulemeester, A. (A.), Wintermans, B.B. (B. B.), Trijp, M.J.C.A. (Marijke) van, Ott, A. (A.), Bathoorn, E. (E.), Lokate, M. (M.), Sinnige, J.C. (J. C.), Brauwer, E.I.G.B. (E. I G B) de, Stals, F.S. (Frans), Silvis, W. (W.), Bakker, L.J. (L. J.), Dorigo-Zetsma, J.W., Ridwan, B. (B.), Waar, K. (K.), Bernards, A.T. (Alexandra), van Mens, S.P. (S. P.), Roescher, N. (N.), Nabuurs-Franssen, M.H. (M. H.), Wertheim, H.F.L. (Heiman), Schülin, T. (Tanja), Diederen, B.M.W. (Bram), Bode, L.G.M. (Lonneke), van Rijn, M. (M.), Dinant, S. (S.), Pontesilli, O. (O.), Man, P. (Peter) de, Leversteijn-van Hall, M.A. (M. A.), Elzakker, E. van, Muller, A.E. (Anouk), Renders, N. (Nicole), van Dam, D.W. (D. W.), Buiting, A.G.M. (Anton), Vlek, A.L.M. (Anne L.M.), Reuland, A. (A.), Frakking, F.N.J. (Florine N.), Overdevest, I. (Ilse), Bosboom, R.W. (R. W.), Trienekens, T.A.M. (T. A.M.), Bruins, M.J. (Marjan), Wolfhagen, M.J.H.M., Zwaluw, K. (Kim) van der, Witteveen, S. (S.), Wielders, L. (L.), van Santen, M. (M.), Landman, F. (F.), de Haan, A. (A.), Schouls, L.M., Bosch, T. (T.), Cohen Stuart, J.W.T. (James), Melles, D.C. (Damian), Dijk, K.D. (Karin) van, Visser, C.E., Notermans, D.W. (Daan), Ogtrop, M.L. van, Werdmuller, B.F.M. (B. F.M.), Hees, B.C. (Babette) van, Kluytmans, J.A.J.W. (Jan), van den Bijllaardt, W. (Wouter), Kraan, E.M. (E. M.), van der Linden, M.P.M. (M. P.M.), Mattsson, E.E. (E. E.), Sebens, F. (Fré), de Jong, E. (E.), Frénay, H.M.E. (H. M.E.), Maraha, B. (B.), Griethuysen, A. (Arjanne) van, van Asselt, G.J. (G. J.), Demeulemeester, A. (A.), Wintermans, B.B. (B. B.), Trijp, M.J.C.A. (Marijke) van, Ott, A. (A.), Bathoorn, E. (E.), Lokate, M. (M.), Sinnige, J.C. (J. C.), Brauwer, E.I.G.B. (E. I G B) de, Stals, F.S. (Frans), Silvis, W. (W.), Bakker, L.J. (L. J.), Dorigo-Zetsma, J.W., Ridwan, B. (B.), Waar, K. (K.), Bernards, A.T. (Alexandra), van Mens, S.P. (S. P.), Roescher, N. (N.), Nabuurs-Franssen, M.H. (M. H.), Wertheim, H.F.L. (Heiman), Schülin, T. (Tanja), Diederen, B.M.W. (Bram), Bode, L.G.M. (Lonneke), van Rijn, M. (M.), Dinant, S. (S.), Pontesilli, O. (O.), Man, P. (Peter) de, Leversteijn-van Hall, M.A. (M. A.), Elzakker, E. van, Muller, A.E. (Anouk), Renders, N. (Nicole), van Dam, D.W. (D. W.), Buiting, A.G.M. (Anton), Vlek, A.L.M. (Anne L.M.), Reuland, A. (A.), Frakking, F.N.J. (Florine N.), Overdevest, I. (Ilse), Bosboom, R.W. (R. W.), Trienekens, T.A.M. (T. A.M.), Bruins, M.J. (Marjan), and Wolfhagen, M.J.H.M.

Abstract

Objectives: Carbapenem resistance mediated by mobile genetic elements has emerged worldwide and has become a major public health threat. To gain insight into the molecular epidemiology of carbapenem resistance in The Netherlands, Dutch medical microbiology laboratories are requested to submit suspected carbapenemase-producing Enterobacterales (CPE) to the National Institute for Public Health and the Environment as part of a national surveillance system. Methods: Meropenem MICs and species identification were confirmed by E-test and MALDI-TOF and carbapenemase production was assessed by the Carbapenem Inactivation Method. Of all submitted CPE, one species/carbapenemase gene combination per person per year was subjected to next-generation sequencing (NGS). Results: In total, 1838 unique isolates were received between 2014 and 2018, of which 892 were unique CPE isolates with NGS data available. The predominant CPE species were Klebsiella pneumoniae (n = 388, 43%), Escherichia coli (n = 264, 30%) and Enterobacter cloacae complex (n = 116, 13%). Various carbapenemase alleles of the same carbapenemase gene resulted in different susceptibilities to meropenem and this effect varied between species. Analyses of NGS data showed variation of prevalence of carbapenemase alleles over time with blaOXA-48 being predominant (38%, 336/892), followed by blaNDM-1 (16%, 145/892). For the first time in the Netherlands, blaOXA-181, blaOXA-232 and blaVIM-4 were detected. The genetic background of K. pneumoniae and E. coli isolates was highly diverse. Conclusions: The CPE population in the Netherlands is diverse, suggesting multiple introductions. The predominant carbapenemase alleles are blaOXA-48 and blaNDM-1. There was a clear association between species, carbapenemase allele and susceptibility to meropenem.

Published
2020
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39. Evaluating the PalliSupport care pathway to improve palliative care and quality of life

Author

Burggraaff, D.L., Holstege, M. (Thesis Advisor), Rijn, M. van, Burggraaff, D.L., Holstege, M. (Thesis Advisor), and Rijn, M. van

Abstract

Background: Patients, families and healthcare professionals have experienced barriers in palliative care. To support patients and reduce these barriers, the PalliSupport care pathway was developed. However, since this care pathway was implemented for the first time, the experiences and perspectives of patients as well as the process of implementation are still unknown. It is important to understand how the PalliSupport care pathway influences outcomes and to gain insight into its implementation before carrying out the care pathway. Aim: To explore the experiences and perspectives of patients in the palliative phase of the PalliSupport care pathway and to provide insight into what extent the components, according to study protocol, of the PalliSupport care pathway were implemented. Methods: A convergent parallel mixed-method design was conducted. Qualitative and quantitative data were collected through semi-structured interviews, questionnaires, study records and electronic health records. Results: After conducting interviews with patients, it was discovered they had different expectations of the conversations and their hospital care or they had not thought about end-of-life. Furthermore, expectations of PalliSupport changed in the hospital and at home. Some patients thought the hospital was the right place to talk about palliative care, while other patients did not remember the conversations. In total, 29 components of the PalliSupport care pathway were implemented and measured. The extent of implementation for these components ranged from 0.0% to 94.4%. In the lowest component, no district nurse was invited for a warm handover in the hospital. In the highest component, the general practitioners received a medical handover. Conclusion: A first overview is given of the experiences and perspectives of patients and the implemented components of the PalliSupport care pathway. It is important to accommodate the wishes of patients and to conduct in-depth research into som

Published
2020

44. Third-generation cephalosporin and carbapenem resistance in Streptococcus mitis/oralis. Results from a nationwide registry in the Netherlands

Author

Stuart, J.W.T. Cohen, Weersink, A.J.L., van Dijk, K., Notermans, D., van Ogtrop, M.L., Jager, M.M., Werdmuller, B.F.M., van Hees, B.C., van Keulen, P.H.J., Alblas, J., Altorf-van der Kuil, W., Blijboom, L., de Greeff, S.C., Groenendijk, S., van Heereveld, J., Hertroys, R., Monen, J.C., Notermans, D.W., Reuland, E.A., Schoffelen, A.F., van Triest, M.I., Wielders, C.C.H., Woudt, S.H.S., Kluytmans, J.A.J.W., Kraan, E.M., Mattsson, E.E., Sebens, F.W., de Jong, E., Frénay, H.M.E., Maraha, B., van Griethuysen, A.J., Demeulemeester, A., Wintermans, B.B., van Trijp, M., Ott, A., E. Bathoorn, Lokate, M., Sinnige, J., de Brauwer, E.I.G.B., Stals, F.S., Silvis, W., Bakker, L.J., Dorigo-Zetsma, J.W., Ridwan, B., Waar, K., Bernards, A.T., van Mens, S.P., Roescher, N., Nabuurs-Franssen, M.H., Wertheim, H., Diederen, B.M.W., Bode, L., van Rijn, M., Dinant, S., Pontesilli, O., de Man, P., Hall, M.A. Leversteijn-van, van Elzakker, E.P.M., Muller, A.E., Renders, N.H., van Dam, D.W., Buiting, A.G.M., Vlek, A.L.M., Reuland, A., Frakking, F.N.J., Overdevest, I.T.M.A., Bosboom, R.W., Trienekens, T., Ruijs, G.J.H.M., Wolfhagen, M.J.H.M., and van Prehn, J.

Published
2019
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45. Molecular characteristics of carbapenemase-producing Enterobacterales in the Netherlands; results of the 2014–2018 national laboratory surveillance

Author

van der Zwaluw, K., primary, Witteveen, S., additional, Wielders, L., additional, van Santen, M., additional, Landman, F., additional, de Haan, A., additional, Schouls, L.M., additional, Bosch, T., additional, Cohen Stuart, J.W.T., additional, Melles, D.C., additional, van Dijk, K., additional, Visser, C.E., additional, Notermans, D.W., additional, van Ogtrop, M.L., additional, Werdmuller, B.F.M., additional, van Hees, B.C., additional, Kluytmans, J.A.J.W., additional, van den Bijllaardt, W., additional, Kraan, E.M., additional, van der Linden, M.P.M., additional, Mattsson, E.E., additional, Sebens, F.W., additional, de Jong, E., additional, Frénay, H.M.E., additional, Maraha, B., additional, van Griethuysen, A.J., additional, van Asselt, G.J., additional, Demeulemeester, A., additional, Wintermans, B.B., additional, van Trijp, M., additional, Ott, A., additional, Bathoorn, E., additional, Lokate, M., additional, Sinnige, J.C., additional, de Brauwer, E.I.G.B., additional, Stals, F.S., additional, Silvis, W., additional, Bakker, L.J., additional, Dorigo-Zetsma, J.W., additional, Ridwan, B., additional, Waar, K., additional, Bernards, A.T., additional, van Mens, S.P., additional, Roescher, N., additional, Nabuurs-Franssen, M.H., additional, Wertheim, H., additional, Schülin, T., additional, Diederen, B.M.W., additional, Bode, L., additional, van Rijn, M., additional, Dinant, S., additional, Pontesilli, O., additional, de Man, P., additional, Leversteijn-van Hall, M.A., additional, van Elzakker, E.P.M., additional, Muller, A.E., additional, Renders, N.H., additional, van Dam, D.W., additional, Buiting, A.G.M., additional, Vlek, A.L.M., additional, Reuland, A., additional, Frakking, F.N.J., additional, Overdevest, I.T.M.A., additional, Bosboom, R.W., additional, Trienekens, T.A.M., additional, Bruins, M.J., additional, and Wolfhagen, M.J.H.M., additional

Published
2020
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