1. Development of functional Haemophilus influenzae type b antibodies after vaccination.
- Author
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van der Velden AM, Claessen AM, van Velzen-Blad H, Biesma DH, and Rijker GT
- Subjects
- Adult, Antibodies, Bacterial blood, Bacterial Capsules, Haemophilus Infections blood, Haemophilus Infections immunology, Haemophilus Infections prevention & control, Haemophilus Vaccines administration & dosage, Haemophilus influenzae type b immunology, Humans, Polysaccharides, Bacterial administration & dosage, Stem Cell Transplantation adverse effects, Antibodies, Bacterial biosynthesis, Haemophilus Vaccines immunology, Haemophilus Vaccines therapeutic use, Haemophilus influenzae type b metabolism, Polysaccharides, Bacterial immunology, Polysaccharides, Bacterial therapeutic use
- Abstract
Sixteen autologous stem cell transplant recipients received three vaccinations with conjugated haemophilus influenzae type b vaccine. Quantitative and qualitative aspects of the antibody response were studied. The vaccination schedule resulted in high antibody response rates and functional maturation of antibodies, as measured by antibody avidity and phagocytosis-inducing capacity.
- Published
- 2005