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2. Using Robson's Ten‐Group Classification System for comparing caesarean section rates in Europe: an analysis of routine data from the Euro‐Peristat study

Author

Zeitlin, J., Durox, M., Macfarlane, A. J., Alexander, S., Heller, G., Loghi, M., Nijhuis, J., Sól Ólafsdóttir, H., Mierzejewska, E., Gissler, M., Blondel, B., Haidinger, G., Klimont, J., Vandervelpen, G., Zhang, W-H., Jordanova, E., Kolarova, R., Filipovic‐Grcic, B., Drausnik, Z., Rodin, U., Kyprianou, T., Scoutellas, V., Velebil, P., Mortensen, L., Sakkeus, L., Heino, A., Chantry, A., Deneux Tharaux, C., Lack, N., Antsaklis, A., Berbik, I., Bonham, S., Kearns, K., Sikora, I., Cuttini, M., Misins, J., Zile, I., Isakova, J., Billy, A., Couffignal, S., Lecomte, A., Weber, G., Gatt, M., Achterberg, P., Broeders, L., Hindori‐Mohangoo, A., Akerkar, R., Klungsøyr, K., Szamotulska, K., Barros, H., Horga, M., Tica, V., Cap, J., Tul, N., Verdenik, I., Bolumar, F., Jané, M., Alcaide, A. R., Vidal, M. J., Zurriaga, O., Kallen, K., Nyman, A., Berrut, S., Riggenbach, M., Rihs, T. A., Smith, L., Woods, R., Delnord, M., Hocquette, A., RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: MA Obstetrie Gynaecologie (3), Obstetrie & Gynaecologie, and Instituto de Saúde Pública da Universidade do Porto

Subjects
medicine.medical_specialty, ten-group classification system, Epidemiology, RJ, medicine.medical_treatment, Population, RT, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, RA0421, medicine, Humans, Caesarean section, Ten‐Group Classification System, education, perinatal health indicators, reproductive and urinary physiology, education.field_of_study, 030219 obstetrics & reproductive medicine, Cesarean Section, Singleton, business.industry, Obstetrics, Obstetrics and Gynecology, Gestational age, Original Articles, Corrigenda, Robson classification, Ten group classification system, Europe, Caesarean Birth, Data quality, health information systems, Female, Original Article, Caesarean birth, Observational study, RG, business, Live Birth
Abstract

Objective Robson's Ten Group Classification System (TGCS) creates clinically relevant sub‐groups for monitoring caesarean birth rates. This study assesses whether this classification can be derived from routine data in Europe and uses it to analyse national caesarean rates. Design Observational study using routine data. Setting Twenty‐seven EU member states plus Iceland, Norway, Switzerland and the UK. Population All births at ≥22 weeks of gestational age in 2015. Methods National statistical offices and medical birth registers derived numbers of caesarean births in TGCS groups. Main outcome measures Overall caesarean rate, prevalence and caesarean rates in each of the TGCS groups. Results Of 31 countries, 18 were able to provide data on the TGCS groups, with UK data available only from Northern Ireland. Caesarean birth rates ranged from 16.1 to 56.9%. Countries providing TGCS data had lower caesarean rates than countries without data (25.8% versus 32.9%, P = 0.04). Countries with higher caesarean rates tended to have higher rates in all TGCS groups. Substantial heterogeneity was observed, however, especially for groups 5 (previous caesarean section), 6, 7 (nulliparous/multiparous breech) and 10 (singleton cephalic preterm). The differences in percentages of abnormal lies, group 9, illustrate potential misclassification arising from unstandardised definitions. Conclusions Although further validation of data quality is needed, using TGCS in Europe provides valuable comparator and baseline data for benchmarking and surveillance. Higher caesarean rates in countries unable to construct the TGCS suggest that effective routine information systems may be an indicator of a country's investment in implementing evidence‐based caesarean policies. Tweetable abstract Many European countries can provide Robson's Ten‐Group Classification to improve caesarean rate comparisons., Tweetable abstract Many European countries can provide Robson's Ten‐Group Classification to improve caesarean rate comparisons.

Published
2021
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3. The international Perinatal Outcomes in the Pandemic (iPOP) study:protocol [version 1; peer review: awaiting peer review]

Author

Stock, SJ, Zoega, H, Brockway, M, Mulholland, RH, Miller, JE, Been, JV, Wood, R, Abok, II, Alshaikh, B, Ayede, AI, Bacchini, F, Bhutta, ZA, Brew, BK, Brook, J, Calvert, C, Campbell-Yeo, M, Chan, D, Chirombo, J, Connor, KL, Daly, M, Einarsdóttir, K, Fantasia, I, Franklin, M, Fraser, A, Håberg, SE, Hui, L, Huicho, L, Magnus, MC, Morris, AD, Nagy-Bonnard, L, Nassar, N, Nyadanu, SD, Iyabode Olabisi, D, Palmer, KR, Pedersen, Lars Henning, Pereira, G, Racine-Poon, A, Ranger, M, Rihs, T, Saner, C, Sheikh, A, Swift, EM, Tooke, L, Urquia, ML, Whitehead, C, Yilgwan, C, Rodriguez, N, Burgner, D, and Azad, MB

Published
2021
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4. The international Perinatal Outcomes in the Pandemic (iPOP) study: Protocol

Author

Stock, SJ, Zoega, H ; https://orcid.org/0000-0003-0761-9028, Brockway, M, Mulholland, RH, Miller, JE, Been, JV, Wood, R, Abok, II, Alshaikh, B, Ayede, AI, Bacchini, F, Bhutta, ZA, Brew, BK, Brook, J, Calvert, C, Campbell-Yeo, M, Chan, D, Chirombo, J, Connor, KL, Daly, M, Einarsdóttir, K, Fantasia, I, Franklin, M, Fraser, A, Håberg, SE, Hui, L, Huicho, L, Magnus, MC, Morris, AD, Nagy-Bonnard, L, Nassar, N, Nyadanu, SD, Iyabode Olabisi, D, Palmer, KR, Pedersen, LH, Pereira, G, Racine-Poon, A, Ranger, M, Rihs, T, Saner, C, Sheikh, A, Swift, EM, Tooke, L, Urquia, ML, Whitehead, C, Yilgwan, C, Rodriguez, N, Burgner, D, Azad, MB, Haasdyk, Bronwyn Brew ; https://orcid.org/0000-0002-9885-8261, Stock, SJ, Zoega, H ; https://orcid.org/0000-0003-0761-9028, Brockway, M, Mulholland, RH, Miller, JE, Been, JV, Wood, R, Abok, II, Alshaikh, B, Ayede, AI, Bacchini, F, Bhutta, ZA, Brew, BK, Brook, J, Calvert, C, Campbell-Yeo, M, Chan, D, Chirombo, J, Connor, KL, Daly, M, Einarsdóttir, K, Fantasia, I, Franklin, M, Fraser, A, Håberg, SE, Hui, L, Huicho, L, Magnus, MC, Morris, AD, Nagy-Bonnard, L, Nassar, N, Nyadanu, SD, Iyabode Olabisi, D, Palmer, KR, Pedersen, LH, Pereira, G, Racine-Poon, A, Ranger, M, Rihs, T, Saner, C, Sheikh, A, Swift, EM, Tooke, L, Urquia, ML, Whitehead, C, Yilgwan, C, Rodriguez, N, Burgner, D, Azad, MB, and Haasdyk, Bronwyn Brew ; https://orcid.org/0000-0002-9885-8261

Abstract

Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread 'natural experiment' of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide cr

Published
2021

19. Socioeconomic disparities in changes to preterm birth and stillbirth rates during the first year of the COVID-19 pandemic: a study of 21 European countries.

Author

Zeitlin J, Philibert M, Barros H, Broeders L, Cap J, Draušnik Ž, Engjom H, Farr A, Fresson J, Gatt M, Gissler M, Heller G, Isakova J, Källén K, Kyprianou T, Loghi M, Monteath K, Mortensen L, Rihs T, Sakkeus L, Sikora I, Szamotulska K, Velebil P, Verdenik I, Weber G, Zile I, Zurriaga O, and Smith L

Subjects
Humans, Europe epidemiology, Female, Pregnancy, Adult, Socioeconomic Factors, Pandemics, Social Class, Health Status Disparities, Infant, Newborn, Pregnancy Outcome epidemiology, Socioeconomic Disparities in Health, Stillbirth epidemiology, COVID-19 epidemiology, Premature Birth epidemiology, SARS-CoV-2
Abstract

Background: Despite concerns about worsening pregnancy outcomes resulting from healthcare restrictions, economic difficulties and increased stress during the COVID-19 pandemic, preterm birth (PTB) rates declined in some countries in 2020, while stillbirth rates appeared stable. Like other shocks, the pandemic may have exacerbated existing socioeconomic disparities in pregnancy, but this remains to be established. Our objective was to investigate changes in PTB and stillbirth by socioeconomic status (SES) in European countries., Methods: The Euro-Peristat network implemented this study within the Population Health Information Research Infrastructure (PHIRI) project. A common data model was developed to collect aggregated tables from routine birth data for 2015-2020. SES was based on mother's educational level or area-level deprivation/maternal occupation if education was unavailable and harmonized into low, medium and high SES. Country-specific relative risks (RRs) of PTB and stillbirth for March to December 2020, adjusted for linear trends from 2015 to 2019, by SES group were pooled using random effects meta-analysis., Results: Twenty-one countries provided data on perinatal outcomes by SES. PTB declined by an average 4% in 2020 {pooled RR: 0.96 [95% confidence intervals (CIs): 0.94-0.97]} with similar estimates across all SES groups. Stillbirths rose by 5% [RR: 1.05 (95% CI: 0.99-1.10)], with increases of between 3 and 6% across the three SES groups, with overlapping confidence limits., Conclusions: PTB decreases were similar regardless of SES group, while stillbirth rates rose without marked differences between groups., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Public Health Association.)

Published
2024
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20. International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries.

Author

Hocquette A, Durox M, Wood R, Klungsøyr K, Szamotulska K, Berrut S, Rihs T, Kyprianou T, Sakkeus L, Lecomte A, Zile I, Alexander S, Klimont J, Barros H, Gatt M, Isakova J, Blondel B, Gissler M, and Zeitlin J

Abstract

Background: To inform the on-going debate about the use of universal prescriptive versus national intrauterine growth charts, we compared perinatal mortality for small and large-for-gestational-age (SGA/LGA) infants according to international and national charts in Europe., Methods: We classified singleton births from 33 to 42 weeks of gestation in 2010 and 2014 from 15 countries ( N  = 1,475,457) as SGA (birthweight <10th percentile) and LGA (>90th percentile) using the international Intergrowth-21st newborn standards and national charts based on the customised charts methodology. We computed sex-adjusted odds ratios (aOR) for stillbirth, neonatal and extended perinatal mortality by this classification using multilevel models., Findings: SGA and LGA prevalence using national charts were near 10% in all countries, but varied according to international charts with a north to south gradient (3.0% to 10.1% and 24.9% to 8.0%, respectively). Compared with appropriate for gestational age (AGA) infants by both charts, risk of perinatal mortality was increased for SGA by both charts (aOR[95% confidence interval (CI)]=6.1 [5.6-6.7]) and infants reclassified by international charts from SGA to AGA (2.7 [2.3-3.1]), but decreased for those reclassified from AGA to LGA (0.6 [0.4-0.7]). Results were similar for stillbirth and neonatal death., Interpretation: Using international instead of national charts in Europe could lead to growth restricted infants being reclassified as having normal growth, while infants with low risks of mortality could be reclassified as having excessive growth., Funding: InfAct Joint Action, CHAFEA Grant n°801,553 and EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking ConcePTION grant n°821,520. AH received a PhD grant from EHESP., Competing Interests: No conflict of interest to disclose., (© 2021 The Authors.)

Published
2021
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21. From swing to cane: Sex differences of EEG resting-state temporal patterns during maturation and aging.

Author

Tomescu MI, Rihs TA, Rochas V, Hardmeier M, Britz J, Allali G, Fuhr P, Eliez S, and Michel CM

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Canes, Child, Female, Humans, Male, Middle Aged, Young Adult, Aging physiology, Brain physiology, Electroencephalography, Rest physiology, Sex Characteristics
Abstract

While many insights on brain development and aging have been gained by studying resting-state networks with fMRI, relating these changes to cognitive functions is limited by the temporal resolution of fMRI. In order to better grasp short-lasting and dynamically changing mental activities, an increasing number of studies utilize EEG to define resting-state networks, thereby often using the concept of EEG microstates. These are brief (around 100 ms) periods of stable scalp potential fields that are influenced by cognitive states and are sensitive to neuropsychiatric diseases. Despite the rising popularity of the EEG microstate approach, information about age changes is sparse and nothing is known about sex differences. Here we investigated age and sex related changes of the temporal dynamics of EEG microstates in 179 healthy individuals (6-87 years old, 90 females, 204-channel EEG). We show strong sex-specific changes in microstate dynamics during adolescence as well as at older age. In addition, males and females differ in the duration and occurrence of specific microstates. These results are of relevance for the comparison of studies in populations of different age and sex and for the understanding of the changes in neuropsychiatric diseases., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2018
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22. 40 Hz Auditory Steady-State Response: The Impact of Handedness and Gender.

Author

Melynyte S, Pipinis E, Genyte V, Voicikas A, Rihs T, and Griskova-Bulanova I

Subjects
Acoustic Stimulation, Adult, Electroencephalography, Female, Humans, Male, Sex Factors, Young Adult, Evoked Potentials, Auditory physiology, Functional Laterality physiology, Temporal Lobe physiology
Abstract

The 40 Hz auditory steady-state response (ASSR) is a periodic response to a periodic stimulation. Its sources are located in the primary auditory cortex and the asymmetry of the planum temporale has previously been associated with hand preference and gender-related differences; thus subject's handedness and gender could potentially influence ASSRs. Nevertheless, electrophysiological studies of ASSRs are mainly dominated by right-handed participants and the observed findings can only be generalized to the right-handed populations. However, for a potential use of 40 Hz ASSR as a translational biomarker of neuropsychiatric disorders, it is important to investigate the response in association to handedness and gender. We included an equal number of left-handed and right-handed males and females and recorded EEG responses during left-ear, right-ear and both ears stimulation. The results of the study suggest that the processing of 40 Hz auditory stimulation depends on the subjects' gender and handedness: significantly lower phase-locking and strength of 40 Hz ASSRs were observed in left-handed females as compared to left-handed males, but right-handers did not differ in 40 Hz ASSRs. Our observation of the opposite impact of gender in the examined handedness groups stresses the importance of careful consideration of handedness and gender factors when evaluating the determinants of inter individual variability of 40 Hz ASSRs. This finding is of particular importance for clinical studies in psychiatry and neurology.

Published
2018
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23. Abstracts of Presentations at the International Conference on Basic and Clinical Multimodal Imaging (BaCI), a Joint Conference of the International Society for Neuroimaging in Psychiatry (ISNIP), the International Society for Functional Source Imaging (ISFSI), the International Society for Bioelectromagnetism (ISBEM), the International Society for Brain Electromagnetic Topography (ISBET), and the EEG and Clinical Neuroscience Society (ECNS), in Geneva, Switzerland, September 5-8, 2013.

Author

He BJ, Nolte G, Nagata K, Takano D, Yamazaki T, Fujimaki Y, Maeda T, Satoh Y, Heckers S, George MS, Lopes da Silva F, de Munck JC, Van Houdt PJ, Verdaasdonk RM, Ossenblok P, Mullinger K, Bowtell R, Bagshaw AP, Keeser D, Karch S, Segmiller F, Hantschk I, Berman A, Padberg F, Pogarell O, Scharnowski F, Karch S, Hümmer S, Keeser D, Paolini M, Kirsch V, Koller G, Rauchmann B, Kupka M, Blautzik J, Pogarell O, Razavi N, Jann K, Koenig T, Kottlow M, Hauf M, Strik W, Dierks T, Gotman J, Vulliemoz S, Lu Y, Zhang H, Yang L, Worrell G, He B, Gruber O, Piguet C, Hubl D, Homan P, Kindler J, Dierks T, Kim K, Steinhoff U, Wakai R, Koenig T, Kottlow M, Melie-García L, Mucci A, Volpe U, Prinster A, Salvatore M, Galderisi S, Linden DE, Brandeis D, Schroeder CE, Kayser C, Panzeri S, Kleinschmidt A, Ritter P, Walther S, Haueisen J, Lau S, Flemming L, Sonntag H, Maess B, Knösche TR, Lanfer B, Dannhauer M, Wolters CH, Stenroos M, Haueisen J, Wolters C, Aydin U, Lanfer B, Lew S, Lucka F, Ruthotto L, Vorwerk J, Wagner S, Ramon C, Guan C, Ang KK, Chua SG, Kuah WK, Phua KS, Chew E, Zhou H, Chuang KH, Ang BT, Wang C, Zhang H, Yang H, Chin ZY, Yu H, Pan Y, Collins L, Mainsah B, Colwell K, Morton K, Ryan D, Sellers E, Caves K, Throckmorton S, Kübler A, Holz EM, Zickler C, Sellers E, Ryan D, Brown K, Colwell K, Mainsah B, Caves K, Throckmorton S, Collins L, Wennberg R, Ahlfors SP, Grova C, Chowdhury R, Hedrich T, Heers M, Zelmann R, Hall JA, Lina JM, Kobayashi E, Oostendorp T, van Dam P, Oosterhof P, Linnenbank A, Coronel R, van Dessel P, de Bakker J, Rossion B, Jacques C, Witthoft N, Weiner KS, Foster BL, Miller KJ, Hermes D, Parvizi J, Grill-Spector K, Recanzone GH, Murray MM, Haynes JD, Richiardi J, Greicius M, De Lucia M, Müller KR, Formisano E, Smieskova R, Schmidt A, Bendfeldt K, Walter A, Riecher-Rössler A, Borgwardt S, Fusar-Poli P, Eliez S, Schmidt A, Sekihara K, Nagarajan SS, Schoffelen JM, Guggisberg AG, Nolte G, Balazs S, Kermanshahi K, Kiesenhofer W, Binder H, Rattay F, Antal A, Chaieb L, Paulus W, Bodis-Wollner I, Maurer K, Fein G, Camchong J, Johnstone J, Cardenas-Nicolson V, Fiederer LD, Lucka F, Yang S, Vorwerk J, Dümpelmann M, Cosandier-Rimélé D, Schulze-Bonhage A, Aertsen A, Speck O, Wolters CH, Ball T, Fuchs M, Wagner M, Kastner J, Tech R, Dinh C, Haueisen J, Baumgarten D, Hämäläinen MS, Lau S, Vogrin SJ, D'Souza W, Haueisen J, Cook MJ, Custo A, Van De Ville D, Vulliemoz S, Grouiller F, Michel CM, Malmivuo J, Aydin U, Vorwerk J, Küpper P, Heers M, Kugel H, Wellmer J, Kellinghaus C, Scherg M, Rampp S, Wolters C, Storti SF, Boscolo Galazzo I, Del Felice A, Pizzini FB, Arcaro C, Formaggio E, Mai R, Manganotti P, Koessler L, Vignal J, Cecchin T, Colnat-Coulbois S, Vespignani H, Ramantani G, Maillard L, Rektor I, Kuba R, Brázdil M, Chrastina J, Rektorova I, van Mierlo P, Carrette E, Strobbe G, Montes-Restrepo V, Vonck K, Vandenberghe S, Ahmed B, Brodely C, Carlson C, Kuzniecky R, Devinsky O, French J, Thesen T, Bénis D, David O, Lachaux JP, Seigneuret E, Krack P, Fraix V, Chabardès S, Bastin J, Jann K, Gee D, Kilroy E, Cannon T, Wang DJ, Hale JR, Mayhew SD, Przezdzik I, Arvanitis TN, Bagshaw AP, Plomp G, Quairiaux C, Astolfi L, Michel CM, Mayhew SD, Mullinger KJ, Bagshaw AP, Bowtell R, Francis ST, Schouten AC, Campfens SF, van der Kooij H, Koles Z, Lind J, Flor-Henry P, Wirth M, Haase CM, Villeneuve S, Vogel J, Jagust WJ, Kambeitz-Ilankovic L, Simon-Vermot L, Gesierich B, Duering M, Ewers M, Rektorova I, Krajcovicova L, Marecek R, Mikl M, Bracht T, Horn H, Strik W, Federspiel A, Schnell S, Höfle O, Stegmayer K, Wiest R, Dierks T, Müller TJ, Walther S, Surmeli T, Ertem A, Eralp E, Kos IH, Skrandies W, Flüggen S, Klein A, Britz J, Díaz Hernàndez L, Ro T, Michel CM, Lenartowicz A, Lau E, Rodriguez C, Cohen MS, Loo SK, Di Lorenzo G, Pagani M, Monaco L, Daverio A, Giannoudas I, La Porta P, Verardo AR, Niolu C, Fernandez I, Siracusano A, Flor-Henry P, Lind J, Koles Z, Bollmann S, Ghisleni C, O'Gorman R, Poil SS, Klaver P, Michels L, Martin E, Ball J, Eich-Höchli D, Brandeis D, Salisbury DF, Murphy TK, Butera CD, Mathalon DH, Fryer SL, Kiehl KA, Calhoun VC, Pearlson GD, Roach BJ, Ford JM, McGlashan TH, Woods SW, Volpe U, Merlotti E, Vignapiano A, Montefusco V, Plescia GM, Gallo O, Romano P, Mucci A, Galderisi S, Mingoia G, Langbein K, Dietzek M, Wagner G, Smesny, Scherpiet S, Maitra R, Gaser C, Sauer H, Nenadic I, Gonzalez Andino S, Grave de Peralta Menendez R, Grave de Peralta Menendez R, Sanchez Vives M, Rebollo B, Gonzalez Andino S, Frølich L, Andersen TS, Mørup M, Belfiore P, Gargiulo P, Ramon C, Vanhatalo S, Cho JH, Vorwerk J, Wolters CH, Knösche TR, Watanabe T, Kawabata Y, Ukegawa D, Kawabata S, Adachi Y, Sekihara K, Sekihara K, Nagarajan SS, Wagner S, Aydin U, Vorwerk J, Herrmann C, Burger M, Wolters C, Lucka F, Aydin U, Vorwerk J, Burger M, Wolters C, Bauer M, Trahms L, Sander T, Faber PL, Lehmann D, Gianotti LR, Pascual-Marqui RD, Milz P, Kochi K, Kaneko S, Yamashita S, Yana K, Kalogianni K, Vardy AN, Schouten AC, van der Helm FC, Sorrentino A, Luria G, Aramini R, Hunold A, Funke M, Eichardt R, Haueisen J, Gómez-Aguilar F, Vázquez-Olvera S, Cordova-Fraga T, Castro-López J, Hernández-Gonzalez MA, Solorio-Meza S, Sosa-Aquino M, Bernal-Alvarado JJ, Vargas-Luna M, Vorwerk J, Magyari L, Ludewig J, Oostenveld R, Wolters CH, Vorwerk J, Engwer C, Ludewig J, Wolters C, Sato K, Nishibe T, Furuya M, Yamashiro K, Yana K, Ono T, Puthanmadam Subramaniyam N, Hyttinen J, Lau S, Güllmar D, Flemming L, Haueisen J, Sonntag H, Vorwerk J, Wolters CH, Grasedyck L, Haueisen J, Maeß B, Freitag S, Graichen U, Fiedler P, Strohmeier D, Haueisen J, Stenroos M, Hauk O, Grigutsch M, Felber M, Maess B, Herrmann B, Strobbe G, van Mierlo P, Vandenberghe S, Strobbe G, Cárdenas-Peña D, Montes-Restrepo V, van Mierlo P, Castellanos-Dominguez G, Vandenberghe S, Lanfer B, Paul-Jordanov I, Scherg M, Wolters CH, Ito Y, Sato D, Kamada K, Kobayashi T, Dalal SS, Rampp S, Willomitzer F, Arold O, Fouladi-Movahed S, Häusler G, Stefan H, Ettl S, Zhang S, Zhang Y, Li H, Kong X, Montes-Restrepo V, Strobbe G, van Mierlo P, Vandenberghe S, Wong DD, Bidet-Caulet A, Knight RT, Crone NE, Dalal SS, Birot G, Spinelli L, Vulliémoz S, Seeck M, Michel CM, Emory H, Wells C, Mizrahi N, Vogrin SJ, Lau S, Cook MJ, Karahanoglu FI, Grouiller F, Caballero-Gaudes C, Seeck M, Vulliemoz S, Van De Ville D, Spinelli L, Megevand P, Genetti M, Schaller K, Michel C, Vulliemoz S, Seeck M, Genetti M, Tyrand R, Grouiller F, Vulliemoz S, Spinelli L, Seeck M, Schaller K, Michel CM, Grouiller F, Heinzer S, Delattre B, Lazeyras F, Spinelli L, Pittau F, Seeck M, Ratib O, Vargas M, Garibotto V, Vulliemoz S, Vogrin SJ, Bailey CA, Kean M, Warren AE, Davidson A, Seal M, Harvey AS, Archer JS, Papadopoulou M, Leite M, van Mierlo P, Vonck K, Boon P, Friston K, Marinazzo D, Ramon C, Holmes M, Koessler L, Rikir E, Gavaret M, Bartolomei F, Vignal JP, Vespignani H, Maillard L, Centeno M, Perani S, Pier K, Lemieux L, Clayden J, Clark C, Pressler R, Cross H, Carmichael DW, Spring A, Bessemer R, Pittman D, Aghakhani Y, Federico P, Pittau F, Grouiller F, Vulliémoz S, Gotman J, Badier JM, Bénar CG, Bartolomei F, Cruto C, Chauvel P, Gavaret M, Brodbeck V, van Leeuwen T, Tagliazzuchi E, Melloni L, Laufs H, Griskova-Bulanova I, Dapsys K, Klein C, Hänggi J, Jäncke L, Ehinger BV, Fischer P, Gert AL, Kaufhold L, Weber F, Marchante Fernandez M, Pipa G, König P, Sekihara K, Hiyama E, Koga R, Iannilli E, Michel CM, Bartmuss AL, Gupta N, Hummel T, Boecker R, Holz N, Buchmann AF, Blomeyer D, Plichta MM, Wolf I, Baumeister S, Meyer-Lindenberg A, Banaschewski T, Brandeis D, Laucht M, Natahara S, Ueno M, Kobayashi T, Kottlow M, Bänninger A, Koenig T, Schwab S, Koenig T, Federspiel A, Dierks T, Jann K, Natsukawa H, Kobayashi T, Tüshaus L, Koenig T, Kottlow M, Achermann P, Wilson RS, Mayhew SD, Assecondi S, Arvanitis TN, Bagshaw AP, Darque A, Rihs TA, Grouiller F, Lazeyras F, Ha-Vinh Leuchter R, Caballero C, Michel CM, Hüppi PS, Hauser TU, Hunt LT, 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R, Mellic G, Copland D, Bänninger A, Kottlow M, Díaz Hernàndez L, Koenig T, Díaz Hernàndez L, Bänninger A, Koenig T, Hauser TU, Iannaccone R, Mathys C, Ball J, Drechsler R, Brandeis D, Walitza S, Brem S, Boeijinga PH, Pang EW, Valica T, Macdonald MJ, Oh A, Lerch JP, Anagnostou E, Di Lorenzo G, Pagani M, Monaco L, Daverio A, Verardo AR, Giannoudas I, La Porta P, Niolu C, Fernandez I, Siracusano A, Shimada T, Matsuda Y, Monkawa A, Monkawa T, Hashimoto R, Watanabe K, Kawasaki Y, Matsuda Y, Shimada T, Monkawa T, Monkawa A, Watanabe K, Kawasaki Y, Stegmayer K, Horn H, Federspiel A, Razavi N, Bracht T, Laimböck K, Strik W, Dierks T, Wiest R, Müller TJ, Walther S, Koorenhof LJ, Swithenby SJ, Martins-Mourao A, Rihs TA, Tomescu M, Song KW, Custo A, Knebel JF, Murray M, Eliez S, Michel CM, Volpe U, Merlotti E, Vignapiano A, Montefusco V, Plescia GM, Gallo O, Romano P, Mucci A, Galderisi S, Laimboeck K, Jann K, Walther S, Federspiel A, Wiest R, Strik W, and Horn H

Published
2013
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24. Resting electroencephalogram alpha-power over posterior sites indexes baseline visual cortex excitability.

Author

Romei V, Rihs T, Brodbeck V, and Thut G

Subjects
Adult, Brain Mapping, Electroencephalography, Female, Humans, Illusions physiology, Male, Neuropsychological Tests, Photic Stimulation, Sensory Thresholds physiology, Transcranial Magnetic Stimulation, Visual Cortex anatomy & histology, Alpha Rhythm, Biological Clocks physiology, Evoked Potentials, Visual physiology, Visual Cortex physiology, Visual Perception physiology
Abstract

Variations of oscillatory brain activity have been related to distinct functional states depending on the frequency of oscillations. In the alpha-band (about 8-14 Hz), decreased oscillatory activity is thought to reflect a state of enhanced cortical excitability, and increased activity to reflect a state of cortical idling or inhibition in which excitability is reduced, but the alpha/excitability link has not been probed directly. Here, we studied the relationship between resting oscillatory activity and visual cortex excitability across participants using electroencephalography and transcranial magnetic stimulation to the occipital pole. We found individual posterior alpha-band power to correlate with the individual threshold for eliciting illusory, transcranial magnetic stimulation-induced visual percepts. This provides direct support for an alpha/excitability link and for baseline states of the visual brain to vary across individuals.

Published
2008
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25. Survey of aflatoxin content in Swiss concentrate feeds for dairy cattle.

Author

Hüni K, Schneider J, Zanetti G, and Rihs T

Subjects
Animal Feed standards, Animals, Dairy Products standards, Switzerland, Aflatoxins analysis, Animal Feed analysis, Cattle
Abstract

Within the context of restrictive Federal measures, the Swiss concentrate feeds for dairy cattle have been periodically surveyed and analyzed for aflatoxin content. In these commercial feeds, the average aflatoxin B1 content decreased sharply from 47 micrograms/kg in the winter of 1976-1977 (period prior to restrictive measures) to 24 micrograms/kg in the winter of 1977-1978 and to 3 micrograms/kg in the winter of 1978-1979. Work made public by the Federal Office of Public Health, reveals a corresponding downward trend for aflatoxin M1 concentration levels in milk from 109 ng/kg in the winter of 1976-1977 to 44 ng/kg in the winter of 1977-1978 and to 10 ng/kg in the winter of 1978-1979. This record indicates that the feed control measures taken were effective in reducing milk contamination by aflatoxins.

Published
1990

27. Nucleation and crystal growth of copper(II) 8-hydroxyquinolinate precipitated from mixed solvents.

Author

Rihs T, Thurston MC, and Howick LC

Abstract

The precipitation kinetics of copper(II) 8-hydroxyquinolinate, formed in water-acetone mixtures, have been studied in a stop-flow apparatus by spectrophotometric techniques. Three factors are found to be important in improving the physical characteristics of crystals precipitated from mixed solvents. Supersaturation and growth rate can be controlled uniformly by slow rate of change in solvent composition; the presence of acetone significantly reduces the number of effective nuclei; thirdly, large amounts of organic solvent cause a change in the crystal form and its growth mechanism. At room temperature, copper(II) 8-hydroxyquinolinate is precipitated as a dihydrate from water-acetone mixtures containing 0-60% acetone, and the crystal growth is limited by a diffusion-controlled process. Anhydrous copper(II) 8-hydroxyquinolinate is formed in 70% acetone solutions by a surface-controlled reaction.

Published
1970
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