776 results on '"Rigsby P"'
Search Results
2. Transition into and out of a leadership role
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Ayyala, Rama S., Rigsby, Cynthia K., Servaes, Sabah, Coley, Brian D., and Taylor, George A.
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- 2024
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3. WHO International Standards for antibodies to HPV6 HPV11 HPV31 HPV33 HPV45 HPV52 and HPV58
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Troy J. Kemp, Gitika Panicker, Carina Eklund, Jianhui Nie, Youchun Wang, Simon Beddows, Peter Rigsby, Weijin Huang, Joakim Dillner, Elizabeth R. Unger, Ligia A. Pinto, Dianna E. Wilkinson, and the collaborative study participants
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Immunologic diseases. Allergy ,RC581-607 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Previously established World Health Organization (WHO) International Standards (IS) for anti-HPV16 and HPV18 antibodies are used to harmonize results across human papillomavirus (HPV) serology assays. Here, we present an international collaborative study to establish ISs for antibodies against HPV6 (NIBSC code 19/298), HPV11 (20/174), HPV31 (20/176), HPV33 (19/290), HPV45 (20/178), HPV52 (19/296) and HPV58 (19/300). The candidate standards were prepared using sera from naturally infected individuals. Each candidate was shown to be monospecific for reactivity against its indicated HPV type except for the HPV11 candidate, which was also reactive against other types. Expression of antibody levels relative to the relevant candidate IS reduced inter-laboratory variation allowing greater comparability between laboratories. Based on these results, the WHO Expert Committee on Biological Standardization established each of the 7 candidates as the 1st IS for antiserum to its indicated HPV type for use in the standardization of HPV pseudovirion-based neutralization and antibody-binding assays.
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- 2024
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4. A Longitudinal Examination of Mental Health and Marital Functioning of Mothers and Fathers of Autistic Adolescents during COVID-19
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Naomi V. Ekas, Chrystyna D. Kouros, Brock A. Rigsby, Sarah Madison, Julianne Hymel, and Maddy Filippi
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Parents, particularly mothers, of autistic children may be especially vulnerable to the negative effects of COVID-19. The current longitudinal study examined changes in psychological distress (anxiety, depression, stress) and marital functioning of mothers and fathers of autistic children across three time points between April and October 2020, and the extent to which pre-COVID factors predicted changes in these outcomes. Participants were 94 mothers and 58 fathers of autistic children drawn from a larger longitudinal study about family relationships and autistic children's mental health that began prior to the pandemic. Results indicated that mothers reported higher levels of psychological distress compared to fathers in July and October 2020. Although, on average, levels of psychological distress and marital functioning did not significantly change for mothers and fathers, pre-pandemic child functioning and marital satisfaction predicted individual differences in change in marital satisfaction during the pandemic for mothers. Implications of the findings are discussed.
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- 2024
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5. WHO International Standards for antibodies to HPV6 HPV11 HPV31 HPV33 HPV45 HPV52 and HPV58
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Kemp, Troy J., Panicker, Gitika, Eklund, Carina, Nie, Jianhui, Wang, Youchun, Beddows, Simon, Rigsby, Peter, Huang, Weijin, Dillner, Joakim, Unger, Elizabeth R., Pinto, Ligia A., and Wilkinson, Dianna E.
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- 2024
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6. A deep learning approach to using wearable seismocardiography (SCG) for diagnosing aortic valve stenosis and predicting aortic hemodynamics obtained by 4D flow MRI
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Khani, Mahmoud E., Johnson, Ethan M. I., Sodhi, Aparna, Robinson, Joshua, Rigsby, Cynthia K., Allen, Bradly D., and Markl, Michael
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Signal Processing - Abstract
In this paper, we explored the use of deep learning for the prediction of aortic flow metrics obtained using 4D flow MRI using wearable seismocardiography (SCG) devices. 4D flow MRI provides a comprehensive assessment of cardiovascular hemodynamics, but it is costly and time-consuming. We hypothesized that deep learning could be used to identify pathological changes in blood flow, such as elevated peak systolic velocity Vmax in patients with heart valve diseases, from SCG signals. We also investigated the ability of this deep learning technique to differentiate between patients diagnosed with aortic valve stenosis (AS), non-AS patients with a bicuspid aortic valve (BAV), non-AS patients with a mechanical aortic valve (MAV), and healthy subjects with a normal tricuspid aortic valve (TAV). In a study of 77 subjects who underwent same-day 4D flow MRI and SCG, we found that the Vmax values obtained using deep learning and SCGs were in good agreement with those obtained by 4D flow MRI. Additionally, subjects with TAV, BAV, MAV, and AS could be classified with ROC-AUC values of 92%, 95%, 81%, and 83%, respectively. This suggests that SCG obtained using low-cost wearable electronics may be used as a supplement to 4D flow MRI exams or as a screening tool for aortic valve disease., Comment: 16 pages, 4 figures
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- 2023
7. One children’s hospital planning and development process to adhere to the FDA recommendation that babies and young children undergo thyroid function testing after receiving an injection of iodine-containing contrast media for medical imaging
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Bardo, Dianna M. E., Samis, Jill H., Josefson, Jami L., Malakooti, Marcelo R., Tannous, Paul, Fox, Jeremy L., Elhadary, Jennifer, Eichstaedt, Amanda, Gray, Kenneth, Nytko, Agata, and Rigsby, Cynthia K.
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- 2024
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8. A Deep Learning Approach to Using Wearable Seismocardiography (SCG) for Diagnosing Aortic Valve Stenosis and Predicting Aortic Hemodynamics Obtained by 4D Flow MRI
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Ebrahimkhani, Mahmoud, Johnson, Ethan M. I., Sodhi, Aparna, Robinson, Joshua D., Rigsby, Cynthia K., Allen, Bradly D., and Markl, Michael
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- 2023
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9. Highly accelerated compressed sensing 4D flow MRI in congenital and acquired heart disease: comparison of aorta and main pulmonary artery flow parameters with conventional 4D flow MRI in children and young adults
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Sodhi, Aparna, Markl, Michael, Popescu, Andrada R., Griffin, Lindsay M., Robinson, Joshua D., and Rigsby, Cynthia K.
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- 2023
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10. Primary Pathology of the Parapharyngeal Space
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Rigsby, Ryan K. and Bhatt, Alok A.
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- 2023
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11. Preliminary Evaluation of Learning to BREATHE PLUS for University Students: Does a Multi-Modal Adaptive Supplement Strengthen Effects of a Mindfulness-Based Intervention?
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Lucas-Thompson, Rachel G., Prince, Mark A., Rigsby, Brock A., Adams, Melanie S., Miller, Reagan L., Rzonca, Addie, Krause, Jill, Moran, Megan, Piehler, Timothy, Morrell, Nicole, and Shomaker, Lauren
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- 2023
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12. A Bibliometric Horizon Scanning Methodology for Identifying Emerging Topics in the Scientific Literature
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Javier, Artjay, Masimore, Beth, Chase, John, Serpa, F. G., Rigsby, John T., Bryant, Avory, Solka, Jeffrey, and Zelnio, Ryan J.
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Computer Science - Social and Information Networks ,Computer Science - Digital Libraries - Abstract
A bibliometric methodology for scanning for emerging science and technology areas is described, where topics in the science, technology and innovation enterprise are discovered using Latent Dirichlet Allocation, their growth rates are modeled using first-order rate kinetics, and research specialization of various entities in these topics is measured using the location quotient. Multiple interactive visualization interfaces that integrate these results together to assist human analysts are developed. This methodology is demonstrated by analyzing the last five years of publications, patents and grants (~ 14 million documents) showing, for example, that deep learning for machine vision is the fastest growing area, and that China has a stronger focus than the U.S. in this area.
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- 2022
13. Guide to use of ferumoxytol for hepatic vascular assessment as part of dual contrast MRI
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Shah, Risha, VanSyckel, Arielle, Popescu, Andrada R., Rigsby, Cynthia K., and Griffin, Lindsay M.
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- 2023
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14. Perceptions of Educators on Motivational Strategies Influencing Middle School Students in Mathematics Courses
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Amy S. Rigsby
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This qualitative study examined educators' perceptions of motivational strategies influencing and motivating middle school students to comprehend and perform in mathematics courses. This study used interview data from 15 participants with 2 to 30 years of teaching experience. Educators may utilize this information in multiple settings within the classroom to influence and motivate students in mathematics courses. Data collection strategies included one-on-one semi-structured middle school educator interviews. Analysis of data occurred in three phases: (a) categorization of data under the five organizational factors, (b) building the explanation in narrative form, and (c) re-examination of the data. The analysis of the phenomenological study data was based on the theoretical framework of the achievement goal theories - the differences in how people judge their perceptions of competence (Nicholls, 1984) and TARGET structures (Task, Authority, Rewards, Grouping, Evaluation, and Time) (Epstein, 1989). The credibility of the analysis was protected by triangulation of data through multiple sources of evidence, establishment of a chain of evidence, and member checking. The results revealed that current and innovative motivational strategies influenced students in middle school mathematics. The results revealed how educators motivate middle school students through traditional and non-traditional strategies. Five themes emerged from the interview data analysis that contribute to the motivation of middle school students: (1) internal motivation, (2) external motivation, (3) building thinking classrooms, (4) student choice, and (5) building relationships. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2023
15. Boosting Children's Language and Literacy Skills through Blueprint: An Evaluation of Children's Literacy Initiative's Blueprint for Early Literacy, 2017-2019
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Research for Action, Turner, Alyn, Comly, Rachel, Ruemann-Moore, Rebecca, Rigsby, Matthew, Strouf, Kendra, and Kapa, Ryan
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RFA's three-year mixed methods evaluation of Children's Literacy Initiative's language and literacy supports found positive impacts despite higher-than-typical teacher turnover. In pre-K centers receiving CLI supports, teachers were more able to implement effective instructional practices and created richer classroom literacy environments, and children's vocabulary grew faster by an order of magnitude of two-and-a-half months, relative to teachers and children in similar pre-K centers. We observed these impacts consistently throughout the study even though year-to year teacher turnover was higher than national averages. We found that challenges associated with the high turnover inhibited consistently robust implementation of the CLI's intervention. Fewer than one in five teachers received the full intended level of support, and less than half of surveyed teachers reported implementing with fidelity all three of the key instructional approaches of the Blueprint for Early Literacy curriculum supplement (Message Time Plus, Intentional Read Aloud, and Power of Three). Despite variable dosage, the study finds statistically significant positive impact for student learning and teacher practice. This, along with teacher and center director descriptions of ease of use, suggests that CLI's early language and literacy supports are particularly well-suited for improving quality and outcomes in high-need pre-K environments. [Additional funding for Blueprint implementation was provided by Boeing Company Charitable Trust, the 25th Century Foundation, the Caroline Alexander Buck Foundation, and the Capital Group Companies.]
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- 2020
16. Late-gadolinium enhancement is common in older pediatric heart transplant recipients and is associated with lower ejection fraction
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Lawson, Andrew A., Watanabe, Kae, Griffin, Lindsay, Laternser, Christina, Markl, Michael, Rigsby, Cynthia K., Sojka, Melanie, Robinson, Joshua D., and Husain, Nazia
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- 2023
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17. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update
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Bissell, Malenka M., Raimondi, Francesca, Ait Ali, Lamia, Allen, Bradley D., Barker, Alex J., Bolger, Ann, Burris, Nicholas, Carhäll, Carl-Johan, Collins, Jeremy D., Ebbers, Tino, Francois, Christopher J., Frydrychowicz, Alex, Garg, Pankaj, Geiger, Julia, Ha, Hojin, Hennemuth, Anja, Hope, Michael D., Hsiao, Albert, Johnson, Kevin, Kozerke, Sebastian, Ma, Liliana E., Markl, Michael, Martins, Duarte, Messina, Marci, Oechtering, Thekla H., van Ooij, Pim, Rigsby, Cynthia, Rodriguez-Palomares, Jose, Roest, Arno A. W., Roldán-Alzate, Alejandro, Schnell, Susanne, Sotelo, Julio, Stuber, Matthias, Syed, Ali B., Töger, Johannes, van der Geest, Rob, Westenberg, Jos, Zhong, Liang, Zhong, Yumin, Wieben, Oliver, and Dyverfeldt, Petter
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- 2023
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18. Systolic reverse flow derived from 4D flow cardiovascular magnetic resonance in bicuspid aortic valve is associated with aortic dilation and aortic valve stenosis: a cross sectional study in 655 subjects
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Weiss, Elizabeth K., Jarvis, Kelly, Maroun, Anthony, Malaisrie, S. Chris, Mehta, Christopher K., McCarthy, Patrick M., Bonow, Robert O., Avery, Ryan J., Allen, Bradley D., Carr, James C., Rigsby, Cynthia K., and Markl, Michael
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- 2023
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19. Act Local: Climate-Change Policy at the County Level in South Florida
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Ayers-Rigsby, Sara, Kangas, Rachael, Savarese, Michael, and Ransom, Jeff
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- 2023
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20. Building a Foundation to Unify the Language of Climate Change in Historical Archaeology
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Cochran, Lindsey E., Miller, Sarah E., Wholey, Heather, Gougeon, Ramie A, Gaillard, Meg, Murray, Emily Jane, Parker, Katherine, Filoromo, Steven, Ropp, Allyson, Nash, Carole, Smith, Karen Y., Ayers-Rigsby, Sara, Lees, William, Anderson, David G., Lee, Lori, Litynski, McKenna, and Grinnan, Nicole
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- 2023
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21. Impact of pulmonary artery flow distribution on Fontan hemodynamics and flow energetics
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Weiss, Elizabeth K., Robinson, Joshua D., Sodhi, Aparna, Markl, Michael, and Rigsby, Cynthia K.
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- 2023
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22. Children's Literacy Initiative's Blueprint for Early Literacy: Year 2 Evaluation Report
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Research for Action, McCarty, Alyn, Comly, Rachel, Strouf, Kendra, and Rigsby, Matthew
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Research for Action's Year Two evaluation report indicates that most lead teachers demonstrated high fidelity to the key elements of the Blueprint approach in the classroom, though some teachers experienced issues related to differentiating instruction and the simultaneous implementation of Blueprint and Creative Curriculum. The authors found strong evidence of impact on teachers and students: multiple data sources demonstrated that teachers and children in Blueprint centers benefitted from the Blueprint curriculum and professional development. Children in Children's Literacy Initiative (CLI)-served classrooms made 2-3 months of additional progress in vocabulary development compared to children in similar classrooms not supported by CLI. Though less than a quarter of lead teachers in Blueprint classrooms in Spring 2018 received intended amount of training and coaching due to high turnover and variable attendance, most teachers had at least attended the Introduction to Blueprint 3.0 training and received at least one full year's worth of coaching (over 20 hours). This report is comprised of two studies that provide in-depth findings of Year Two Blueprint implementation (resources and activities) and impacts (teacher and student outcomes). Study 1: Blueprint Implementation is a descriptive study of the quality of implementation of Blueprint in 11 Philadelphia pre-K centers. This study also followed up on findings from Year One, including an in-depth exploration of challenges to implementation-- consistent attendance at trainings, finding time for coaching conferences, and coaching amidst high teacher turnover--and CLI strategies to address them. Study 2: Impact of Blueprint on Teachers and Students is a study that employed a mixed-methods quasi-experimental research design, involving 11 centers receiving Blueprint professional development and curriculum and 11 centers serving as a comparison group. [Additional funding for this report was provided by The 25th Century Foundation, The Caroline Alexander Buck Foundation, and The Capital Group Companies.]
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- 2018
23. A new technique for estimating the probability of attentional capture
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Rigsby, Taylor J., Stilwell, Brad T., Ruthruff, Eric, and Gaspelin, Nicholas
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- 2023
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24. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update
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Malenka M. Bissell, Francesca Raimondi, Lamia Ait Ali, Bradley D. Allen, Alex J. Barker, Ann Bolger, Nicholas Burris, Carl-Johan Carhäll, Jeremy D. Collins, Tino Ebbers, Christopher J. Francois, Alex Frydrychowicz, Pankaj Garg, Julia Geiger, Hojin Ha, Anja Hennemuth, Michael D. Hope, Albert Hsiao, Kevin Johnson, Sebastian Kozerke, Liliana E. Ma, Michael Markl, Duarte Martins, Marci Messina, Thekla H. Oechtering, Pim van Ooij, Cynthia Rigsby, Jose Rodriguez-Palomares, Arno A. W. Roest, Alejandro Roldán-Alzate, Susanne Schnell, Julio Sotelo, Matthias Stuber, Ali B. Syed, Johannes Töger, Rob van der Geest, Jos Westenberg, Liang Zhong, Yumin Zhong, Oliver Wieben, and Petter Dyverfeldt
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4D Flow CMR ,4D Flow MRI ,Phase-contrast magnetic resonance imaging ,MR flow imaging ,Hemodynamics ,Flow visualization ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 ‘4D Flow CMR Consensus Statement’. We elaborate on 4D Flow CMR sequence options and imaging considerations. The document aims to assist centers starting out with 4D Flow CMR of the heart and great vessels with advice on acquisition parameters, post-processing workflows and integration into clinical practice. Furthermore, we define minimum quality assurance and validation standards for clinical centers. We also address the challenges faced in quality assurance and validation in the research setting. We also include a checklist for recommended publication standards, specifically for 4D Flow CMR. Finally, we discuss the current limitations and the future of 4D Flow CMR. This updated consensus paper will further facilitate widespread adoption of 4D Flow CMR in the clinical workflow across the globe and aid consistently high-quality publication standards.
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- 2023
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25. Respiratory-resolved five-dimensional flow cardiovascular magnetic resonance : In-vivo validation and respiratory-dependent flow changes in healthy volunteers and patients with congenital heart disease
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Elizabeth K. Weiss, Justin Baraboo, Cynthia K. Rigsby, Joshua D. Robinson, Liliana Ma, Mariana B.L. Falcão, Christopher W. Roy, Matthias Stuber, and Michael Markl
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5D flow CMR ,Respiratory-resolved flow ,Real-time phase-contrast MRI ,Congenital heart disease ,Single ventricle disease ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
ABSTRACT: Background: This study aimed to validate respiratory-resolved five-dimensional (5D) flow cardiovascular magnetic resonance (CMR) against real-time two-dimensional (2D) phase-contrast MRI, assess the impact of number of respiratory states, and measure the impact of respiration on hemodynamics in congenital heart disease (CHD) patients. Methods: Respiratory-resolved 5D flow MRI-derived net and peak flow measurements were compared to real-time 2D phase-contrast MRI-derived measurements in 10 healthy volunteers. Pulmonary-to-systemic flow ratios (Qp:Qs) were measured in 19 CHD patients and aortopulmonary collateral burden was measured in 5 Fontan patients. Additionally, the impact of number of respiratory states on measured respiratory-driven net flow changes was investigated in 10 healthy volunteers and 19 CHD patients (shunt physiology, n = 11, single ventricle disease [SVD], n = 8). Results: There was good agreement between 5D flow MRI and real-time 2D phase-contrast–derived net and peak flow. Respiratory-driven changes had a good correlation (rho = 0.64, p
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- 2024
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26. Multiparametric Cardiovascular Magnetic Resonance Predicts Outcomes in Pediatric Heart Transplant Recipients
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Andrew A. Lawson, MD, Kae Watanabe, MD, Lindsay Griffin, MD, Christina Laternser, PhD, Michael Markl, PhD, Cynthia Rigsby, MD, Melanie Sojka, Joshua Robinson, MD, and Nazia Husain, MD, MPH
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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27. Hemodynamic Effects of Regadenoson Stress Perfusion Under General Anesthesia for Pediatric Heart Transplant Patients
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Nikkan Das, MD, Eric Vu, MD, Andrada Popescu, MD, Defne Magnetta, MD, Cynthia Rigsby, MD, Joseph Camarda, MD, Matthew Cornicelli, MD, Joshua Robinson, MD, Simon Lee, MD, and Nazia Husain, MD, MPH
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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28. Longitudinal Assessment of Hemodynamic Parameters in Children and Young Adults with Marfan Syndrome
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Sodhi Aparna, BA, BA Aparna Sodhi, Elizabeth Weiss, PhD, Ethan Johnson, PhD, Haben Berhane, BSc, Joshua Robinson, MD, Joseph Camarda, MD, Andrada Popescu, MD, Michael Markl, PhD, and Cynthia Rigsby, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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29. Fully Automated Characterization of Multiple Hemodynamic Parameters FBom 4D Flow MRI: A 248-subject Comparison of BAV Patients to Age-matched Healthy Controls
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Ethan Johnson, PhD, Haben Berhane, BSc, Elizabeth Weiss, PhD, Aparna Sodhi, BA, Michael Scott, PhD, Bradley D. Allen, MD, Cynthia Rigsby, MD, and Michael Markl, PhD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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30. 4D Flow Yields Similar Clinical Results Compared to 2D Phase Contrast for Decision Making Regarding Pulmonary Valve Replacement in Repaired Tetralogy of Fallot
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Alison Almgren-Bell, Andrada Popescu, MD, Aparna Sodhi, BA, Michael Markl, PhD, Cynthia Rigsby, MD, and Joshua Robinson, MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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31. Accelerated, FBee-breathing, 3D Cardiac T1ρ Mapping Pulse Sequence with XD-GRASP Reconstruction
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Suvai Gunasekaran, PhD, KyungPyo Hong, PhD, Joshua Robinson, MD, Gregory Webster, MD, MPH, Rod Passman, MD, Daniel Lee, MD, Aggelos Katsaggelos, PhD, Cynthia Rigsby, MD, Walter Witschey, PhD, and Daniel Kim, PhD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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32. Promoting Latinx health equity through community-engaged policy and practice reforms in North Carolina
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Andrea Thoumi, Gabriela Plasencia, Farrah Madanay, Ethan Shih-An Ho, Caroline Palmer, Kamaria Kaalund, Nikhil Chaudhry, Amy Labrador, Kristen Rigsby, Adaobi Onunkwo, Ivan Almonte, Rosa Gonzalez-Guarda, Viviana Martinez-Bianchi, and Rushina Cholera
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health equity ,Latino/Hispanic people ,COVID-19 ,community-engaged research ,community-academic partnership ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionThe Latinx Advocacy Team & Interdisciplinary Network for COVID-19 (LATIN-19) is a unique multi-sector coalition formed early in the COVID-19 pandemic to address the multi-level health inequities faced by Latinx communities in North Carolina.MethodsWe utilized the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework to conduct a directed content analysis of 58 LATIN-19 meeting minutes from April 2020 through October 2021. Application of the NIMHD Research Framework facilitated a comprehensive assessment of complex and multidimensional barriers and interventions contributing to Latinx health while centering on community voices and perspectives.ResultsCommunity interventions focused on reducing language barriers and increasing community-level access to social supports while policy interventions focused on increasing services to slow the spread of COVID-19.DiscussionOur study adds to the literature by identifying community-based strategies to ensure the power of communities is accounted for in policy reforms that affect Latinx health outcomes across the U.S. Multisector coalitions, such as LATIN-19, can enable the improved understanding of underlying barriers and embed community priorities into policy solutions to address health inequities.
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- 2023
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33. Four-dimensional Multiphase Steady-State MRI with Ferumoxytol Enhancement: Early Multicenter Feasibility in Pediatric Congenital Heart Disease.
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Nguyen, Kim-Lien, Ghosh, Reena M, Griffin, Lindsay M, Yoshida, Takegawa, Bedayat, Arash, Rigsby, Cynthia K, Fogel, Mark A, Whitehead, Kevin K, Hu, Peng, and Finn, J Paul
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Humans ,Heart Defects ,Congenital ,Contrast Media ,Magnetic Resonance Imaging ,Prospective Studies ,Feasibility Studies ,Child ,Child ,Preschool ,Infant ,Female ,Male ,Ferrosoferric Oxide ,Cardiovascular ,Pediatric ,Clinical Research ,Biomedical Imaging ,Clinical Trials and Supportive Activities ,Heart Disease ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging - Abstract
Background The value of MRI in pediatric congenital heart disease (CHD) is well recognized; however, the requirement for expert oversight impedes its widespread use. Four-dimensional (4D) multiphase steady-state imaging with contrast enhancement (MUSIC) is a cardiovascular MRI technique that uses ferumoxytol and captures all anatomic features dynamically. Purpose To evaluate multicenter feasibility of 4D MUSIC MRI in pediatric CHD. Materials and Methods In this prospective study, participants with CHD underwent 4D MUSIC MRI at 3.0 T or 1.5 T between 2014 and 2020. From a pool of 460 total studies, an equal number of MRI studies from three sites (n = 60) was chosen for detailed analysis. With use of a five-point scale, the feasibility of 4D MUSIC was scored on the basis of artifacts, image quality, and diagnostic confidence for intracardiac and vascular connections (n = 780). Respiratory motion suppression was assessed by using the signal intensity profile. Bias between 4D MUSIC and two-dimensional (2D) cine imaging was evaluated by using Bland-Altman analysis; 4D MUSIC examination duration was compared with that of the local standard for CHD. Results A total of 206 participants with CHD underwent MRI at 3.0 T, and 254 participants underwent MRI at 1.5 T. Of the 60 MRI examinations chosen for analysis (20 per site; median participant age, 14.4 months [interquartile range, 2.3-49 months]; 33 female participants), 56 (93%) had good or excellent image quality scores across a spectrum of disease complexity (mean score ± standard deviation: 4.3 ± 0.6 for site 1, 4.9 ± 0.3 for site 2, and 4.6 ± 0.7 for site 3; P < .001). Artifact scores were inversely related to image quality (r = -0.88, P < .001) and respiratory motion suppression (P < .001, r = -0.45). Diagnostic confidence was high or definite in 730 of 780 (94%) intracardiac and vascular connections. The correlation between 4D MUSIC and 2D cine ventricular volumes and ejection fraction was high (range of r = 0.72-0.85; P < .001 for all). Compared with local standard MRI, 4D MUSIC reduced the image acquisition time (44 minutes ± 20 vs 12 minutes ± 3, respectively; P < .001). Conclusion Four-dimensional multiphase steady-state imaging with contrast enhancement MRI in pediatric congenital heart disease was feasible in a multicenter setting, shortened the examination time, and simplified the acquisition protocol, independently of disease complexity. Clinical trial registration no. NCT02752191 © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Roest and Lamb in this issue.
- Published
- 2021
34. Systolic reverse flow derived from 4D flow cardiovascular magnetic resonance in bicuspid aortic valve is associated with aortic dilation and aortic valve stenosis: a cross sectional study in 655 subjects
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Elizabeth K. Weiss, Kelly Jarvis, Anthony Maroun, S. Chris Malaisrie, Christopher K. Mehta, Patrick M. McCarthy, Robert O. Bonow, Ryan J. Avery, Bradley D. Allen, James C. Carr, Cynthia K. Rigsby, and Michael Markl
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Bicuspid aortic valve ,Aortic dilation ,Aortic stenosis ,Aortic regurgitation ,4D flow MRI ,Voxel-wise reverse flow ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Bicuspid aortic valve (BAV) disease is associated with increased risk of aortopathy. In addition to current intervention guidelines, BAV mediated changes in aortic 3D hemodynamics have been considered as risk stratification measures. We aimed to evaluate the association of 4D flow cardiovascular magnetic resonance (CMR) derived voxel-wise aortic reverse flow with aortic dilation and to investigate the role of aortic valve regurgitation (AR) and stenosis (AS) on reverse flow in systole and diastole. Methods 510 patients with BAV (52 ± 14 years) and 120 patients with trileaflet aortic valve (TAV) (61 ± 11 years) and mid-ascending aorta diameter (MAAD) > 35 mm who underwent CMR including 4D flow CMR were retrospectively included. An age and sex-matched healthy control cohort (n = 25, 49 ± 12 years) was selected. Voxel-wise reverse flow was calculated in the aorta and quantified by the mean reverse flow in the ascending aorta (AAo) during systole and diastole. Results BAV patients without AS and AR demonstrated significantly increased systolic and diastolic reverse flow (222% and 13% increases respectively, p 17% increase, p 27% decrease, p 0.1). Conclusion 4D flow CMR derived reverse flow associated with BAV was successfully captured even in the absence of AR or AS and in comparison to TAV patients with aortic dilation. Diastolic AAo reverse flow increased with AR severity while AS severity strongly correlated with increased systolic reverse flow in the AAo. Additionally, increasing MAAD was independently associated with increasing systolic AAo reverse flow. Thus, systolic AAo reverse flow may be a valuable metric for evaluating disease severity in future longitudinal outcome studies.
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- 2023
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35. Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI
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Nguyen, Kim-Lien, Yoshida, Takegawa, Kathuria-Prakash, Nikhita, Zaki, Islam H, Varallyay, Csanad G, Semple, Scott I, Saouaf, Rola, Rigsby, Cynthia K, Stoumpos, Sokratis, Whitehead, Kevin K, Griffin, Lindsay M, Saloner, David, Hope, Michael D, Prince, Martin R, Fogel, Mark A, Schiebler, Mark L, Roditi, Giles H, Radjenovic, Aleksandra, Newby, David E, Neuwelt, Edward A, Bashir, Mustafa R, Hu, Peng, and Finn, J Paul
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Biomedical and Clinical Sciences ,Clinical Sciences ,Nutrition ,Patient Safety ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Child ,Child ,Preschool ,Contrast Media ,Drug-Related Side Effects and Adverse Reactions ,Female ,Ferrosoferric Oxide ,Humans ,Infant ,Infant ,Newborn ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Off-Label Use ,Registries ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
Background Ferumoxytol is approved for use in the treatment of iron deficiency anemia, but it can serve as an alternative to gadolinium-based contrast agents. On the basis of postmarketing surveillance data, the Food and Drug Administration issued a black box warning regarding the risks of rare but serious acute hypersensitivity reactions during fast high-dose injection (510 mg iron in 17 seconds) for therapeutic use. Whereas single-center safety data for diagnostic use have been positive, multicenter data are lacking. Purpose To report multicenter safety data for off-label diagnostic ferumoxytol use. Materials and Methods The multicenter ferumoxytol MRI registry was established as an open-label nonrandomized surveillance databank without industry involvement. Each center monitored all ferumoxytol administrations, classified adverse events (AEs) using the National Cancer Institute Common Terminology Criteria for Adverse Events (grade 1-5), and assessed the relationship of AEs to ferumoxytol administration. AEs related to or possibly related to ferumoxytol injection were considered adverse reactions. The core laboratory adjudicated the AEs and classified them with the American College of Radiology (ACR) classification. Analysis of variance was used to compare vital signs. Results Between January 2003 and October 2018, 3215 patients (median age, 58 years; range, 1 day to 96 years; 1897 male patients) received 4240 ferumoxytol injections for MRI. Ferumoxytol dose ranged from 1 to 11 mg per kilogram of body weight (≤510 mg iron; rate ≤45 mg iron/sec). There were no systematic changes in vital signs after ferumoxytol administration (P > .05). No severe, life-threatening, or fatal AEs occurred. Eighty-three (1.9%) of 4240 AEs were related or possibly related to ferumoxytol infusions (75 mild [1.8%], eight moderate [0.2%]). Thirty-one AEs were classified as allergiclike reactions using ACR criteria but were consistent with minor infusion reactions observed with parenteral iron. Conclusion Diagnostic ferumoxytol use was well tolerated, associated with no serious adverse events, and implicated in few adverse reactions. Registry results indicate a positive safety profile for ferumoxytol use in MRI. © RSNA, 2019 Online supplemental material is available for this article.
- Published
- 2019
36. Resident-attending discrepancy rates for two consecutive versus nonconsecutive weeks of overnight shifts
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Rigsby, Ryan K. and Peters, Eric M.
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- 2022
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37. Enhanced 4D Flow MRI-Based CFD with Adaptive Mesh Refinement for Flow Dynamics Assessment in Coarctation of the Aorta
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Shahid, Labib, Rice, James, Berhane, Haben, Rigsby, Cynthia, Robinson, Joshua, Griffin, Lindsay, Markl, Michael, and Roldán-Alzate, Alejandro
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- 2022
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38. Variation in Advanced Diagnostic Imaging Practice Patterns and Associated Risks Prior to Superior Cavopulmonary Connection: A Multicenter Analysis
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Gartenberg, Ari J., Glatz, Andrew C., Nunes, Mariana, Griffin, Lindsay, Rigsby, Cynthia K., Armstrong, Aimee K., Casey, Susan A., Witt, Dawn R., Schmidt, Christian W., Lesser, John, and Han, B. Kelly
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- 2022
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39. Tumor Treating Fields Alter the Kinomic Landscape in Glioblastoma Revealing Therapeutic Vulnerabilities
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Amber B. Jones, Taylor L. Schanel, Mikayla R. Rigsby, Corinne E. Griguer, Braden C. McFarland, Joshua C. Anderson, Christopher D. Willey, and Anita B. Hjelmeland
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glioblastoma ,tumor treating fields ,temozolomide resistance ,kinomics ,Cytology ,QH573-671 - Abstract
Treatment for the deadly brain tumor glioblastoma (GBM) has been improved through the non-invasive addition of alternating electric fields, called tumor treating fields (TTFields). Improving both progression-free and overall survival, TTFields are currently approved for treatment of recurrent GBMs as a monotherapy and in the adjuvant setting alongside TMZ for newly diagnosed GBMs. These TTFields are known to inhibit mitosis, but the full molecular impact of TTFields remains undetermined. Therefore, we sought to understand the ability of TTFields to disrupt the growth patterns of and induce kinomic landscape shifts in TMZ-sensitive and -resistant GBM cells. We determined that TTFields significantly decreased the growth of TMZ-sensitive and -resistant cells. Kinomic profiling predicted kinases that were induced or repressed by TTFields, suggesting possible therapy-specific vulnerabilities. Serving as a potential pro-survival mechanism for TTFields, kinomics predicted the increased activity of platelet-derived growth-factor receptor alpha (PDGFRα). We demonstrated that the addition of the PDGFR inhibitor, crenolanib, to TTFields further reduced cell growth in comparison to either treatment alone. Collectively, our data suggest the efficacy of TTFields in vitro and identify common signaling responses to TTFields in TMZ-sensitive and -resistant populations, which may support more personalized medicine approaches.
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- 2023
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40. The Impact of Coupling Assessments on Conceptual Understanding and Connection-Making in Chemical Equilibrium and Acid-Base Chemistry
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Ye, Li, Eichler, Jack F., Gilewski, Alex, Talbert, Lance E., Mallory, Emily, Litvak, Mikhail, Rigsby, Emily M., Henbest, Grace, Mortezaei, Kiana, and Guregyan, Cybill
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Science educators have developed a variety of assessment techniques to help students connect their scientific knowledge and bridge conceptual gaps. In chemistry, concept maps and creative exercises are the two notable assessments that have been implemented into multiple chemistry courses and indicated promising effects on students' conceptual learning and connection-making between chemistry concepts. These two assessment techniques were usually implemented individually in research studies. Herein, we employed a quasi-experimental, mixed-methods approach to explore whether combining concept maps and creative exercises would reveal any synergistic effects for student learning of chemical equilibrium and acid-base chemistry in a college general chemistry course. In this study, student perceptions of the use of the two assessments were examined by open-ended surveys. Interestingly, students perceived creative exercises as an assessment technique while concept maps were viewed as a learning tool for studying or reviewing exams. Additionally, Students believed that concept maps assisted them in answering creative exercises, but not vice versa. The four study groups (control group, concept maps only, creative exercises only, and both concept maps and creative exercises) were compared through concept inventory pre and post-test questions. The results of an ANCOVA indicated that participation in the experimental groups did not significantly impact conceptual learning gains, as measured by the concept inventory post-test scores. However, focus group interviews indicated students from the experimental group that used both concept maps and creative exercises were able to provide more sophisticated scientific explanations for conceptual questions related to the topics of chemical equilibrium and acid-base chemistry. Implications of these research results, best practices for implementation of the two assessments, and future research are discussed.
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- 2020
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41. Developing Metadiscursive Thinking about Research Methods through a Mixed-Methods Research Project
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Rigsby, Ellen M. and Imamura, Makiko
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This study provides an overview of the shifting epistemological terrain regarding methodological approaches to the research process in the field of communication and discusses how a mixed-methods design could improve methods comprehension in undergraduate education. The authors describe how they incorporated a mixed-methods project into the curriculum and discuss the student experience of learning qualitative and quantitative methods through the mixed-methods project as evidenced by surveys and reflective writing assignments. Specifically, the project reorients students' thinking from qualitative and quantitative methods as separate paradigms. Instead, it fosters a metadiscursive perspective on methods in which research designs and questions are in conversation with each other (Creswell, 2011). The project is structured using the Dimensions of Research in Undergraduate Learning framework (DRUL; Healey & Jenkins, 2009; Ozay, 2012) to foster this conversation by creating an explicit path for the transfer of knowledge between specific methods.
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- 2020
42. Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease
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Harlow, Kathryn E, Africa, Jonathan A, Wells, Alan, Belt, Patricia H, Behling, Cynthia A, Jain, Ajay K, Molleston, Jean P, Newton, Kimberly P, Rosenthal, Philip, Vos, Miriam B, Xanthakos, Stavra A, Lavine, Joel E, Schwimmer, Jeffrey B, Network, Nonalcoholic Steatohepatitis Clinical Research, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Bozic, Molly, Cummings, Oscar W, Klipsch, Ann, Ragozzino, Emily, Sandrasegaran, Kumar, Subbarao, Girish, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Fishbein, Mark H, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Whitington, Peter F, Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Baker, Susan S, Lopez-Graham, Diana, Williams, Sonja, Zhu, Lixin, Awai, Hannah, Bross, Craig, Collins, Jennifer, Durelle, Janis, Middleton, Michael, Paiz, Melissa, Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Courtier, Jesse, Ferrell, Linda D, Feier, Natasha, Gill, Ryan, Langlois, Camille, Perito, Emily Rothbaum, Tsai, Patrika, Cooper, Kara, Horslen, Simon, Hsu, Evelyn, Murray, Karen, Otto, Randolph, Yeh, Matthew, Young, Melissa, Brunt, Elizabeth M, Fowler, Kathryn, Kleiner, David E, Brown, Sherry, Doo, Edward C, and Hoofnagle, Jay H
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Paediatrics ,Biomedical and Clinical Sciences ,Pediatric ,Chronic Liver Disease and Cirrhosis ,Cardiovascular ,Health Disparities ,Obesity ,Minority Health ,Prevention ,Liver Disease ,Digestive Diseases ,Nutrition ,2.4 Surveillance and distribution ,Metabolic and endocrine ,Good Health and Well Being ,Child ,Cholesterol ,LDL ,Diet ,Female ,Humans ,Hypercholesterolemia ,Hypertriglyceridemia ,Life Style ,Longitudinal Studies ,Male ,Non-alcoholic Fatty Liver Disease ,Triglycerides ,Nonalcoholic Steatohepatitis Clinical Research Network ,NAFLD ,cardiovascular ,diet ,dyslipidemia ,pediatric ,statin ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics - Abstract
ObjectiveTo determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines.Study designThis multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network. Fasting lipid profiles were obtained at diagnosis. Standardized dietary recommendations were provided. After 1 year, lipid profiles were repeated and interpreted according to National Heart, Lung, and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction. Main outcomes were meeting criteria for clinically actionable dyslipidemia at baseline, and either achieving lipid goal at follow-up or meeting criteria for ongoing intervention.ResultsThere were 585 participants, with a mean age of 12.8 years. The prevalence of children warranting intervention for low-density lipoprotein cholesterol at baseline was 14%. After 1 year of recommended dietary changes, 51% achieved goal low-density lipoprotein cholesterol, 27% qualified for enhanced dietary and lifestyle modifications, and 22% met criteria for pharmacologic intervention. Elevated triglycerides were more prevalent, with 51% meeting criteria for intervention. At 1 year, 25% achieved goal triglycerides with diet and lifestyle changes, 38% met criteria for advanced dietary modifications, and 37% qualified for antihyperlipidemic medications.ConclusionsMore than one-half of children with NAFLD met intervention thresholds for dyslipidemia. Based on the burden of clinically relevant dyslipidemia, lipid screening in children with NAFLD is warranted. Clinicians caring for children with NAFLD should be familiar with lipid management.
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- 2018
43. In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis
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Africa, Jonathan A, Behling, Cynthia A, Brunt, Elizabeth M, Zhang, Nan, Luo, Yunjun, Wells, Alan, Hou, Jiayi, Belt, Patricia H, Kohil, Rohit, Lavine, Joel E, Molleston, Jean P, Newton, Kimberly P, Whitington, Peter F, Schwimmer, Jeffrey B, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Xanthakos, Stavra, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Vos, Miriam, Bozic, Molly, Cummings, Oscar W, Klipsch, Ann, Ragozzino, Emily, Sandrasegaran, Kumar, Subbarao, Girish, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Fishbein, Mark H, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, Jain, Ajay, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Baker, Susan S, Lopez–Graham, Diana, Williams, Sonja, Zhu, Lixin, Africa, Jonathan, Awai, Hannah, Behling, Cynthia, Bross, Craig, Collins, Jennifer, Durelle, Janis, Harlow, Kathryn, Middleton, Michael, Newton, Kimberly, Paiz, Melissa, Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Courtier, Jesse, Ferrell, Linda D, Feier, Natasha, Gill, Ryan, Langlois, Camille, Perito, Emily Rothbaum, Rosenthal, Philip, Tsai, Patrika, Cooper, Kara, and Horslen, Simon
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Biomedical and Clinical Sciences ,Clinical Sciences ,Pediatric ,Digestive Diseases ,Hepatitis ,Liver Disease ,Chronic Liver Disease and Cirrhosis ,Clinical Research ,Good Health and Well Being ,Adolescent ,Biopsy ,Child ,Cross-Sectional Studies ,Fatty Liver ,Female ,Hepatitis C ,Histocytochemistry ,Humans ,Liver Cirrhosis ,Male ,Non-alcoholic Fatty Liver Disease ,NASH ,Disease Progression ,Obesity ,Nonalcoholic Steatohepatitis Clinical Research Network ,Gastroenterology & Hepatology ,Clinical sciences - Abstract
Background & aimsFocal zone 1 steatosis, although rare in adults with nonalcoholic fatty liver disease (NAFLD), does occur in children with NAFLD. We investigated whether focal zone 1 steatosis and focal zone 3 steatosis are distinct subphenotypes of pediatric NAFLD. We aimed to determine associations between the zonality of steatosis and demographic, clinical, and histologic features in children with NAFLD.MethodsWe performed a cross-sectional study of baseline data from 813 children (age
- Published
- 2018
44. Multi-parametric cardiovascular magnetic resonance with regadenoson stress perfusion is safe following pediatric heart transplantation and identifies history of rejection and cardiac allograft vasculopathy
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Nazia Husain, Kae Watanabe, Haben Berhane, Aditi Gupta, Michael Markl, Cynthia K. Rigsby, and Joshua D. Robinson
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Pediatric heart transplantation ,Cardiovascular magnetic resonance ,CMR stress perfusion ,Parametric mapping ,Cardiac allograft vasculopathy ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background The progressive risk of graft failure in pediatric heart transplantation (PHT) necessitates close surveillance for rejection and coronary allograft vasculopathy (CAV). The current gold standard of surveillance via invasive coronary angiography is costly, imperfect and associated with complications. Our goal was to assess the safety and feasibility of a comprehensive multi-parametric CMR protocol with regadenoson stress perfusion in PHT and evaluate for associations with clinical history of rejection and CAV. Methods We performed a retrospective review of 26 PHT recipients who underwent stress CMR with tissue characterization and compared with 18 age-matched healthy controls. CMR protocol included myocardial T2, T1 and extracellular volume (ECV) mapping, late gadolinium enhancement (LGE), qualitative and semi-quantitative stress perfusion (myocardial perfusion reserve index; MPRI) and strain imaging. Clinical, demographics, rejection score and CAV history were recorded and correlated with CMR parameters. Results Mean age at transplant was 9.3 ± 5.5 years and median duration since transplant was 5.1 years (IQR 7.5 years). One patient had active rejection at the time of CMR, 11/26 (42%) had CAV 1 and 1/26 (4%) had CAV 2. Biventricular volumes were smaller and cardiac output higher in PHT vs. healthy controls. Global T1 (1053 ± 42 ms vs 986 ± 42 ms; p
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- 2021
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45. Asylia : Territorial Inviolability in the Hellenistic World
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Rigsby, Kent J. and Rigsby, Kent J.
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- 2023
46. Measuring Up: Teachers' Perceptions of a New Evaluation System
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Darnisha Rigsby and Jennifer T. Butcher
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Teacher appraisal and evaluation systems have increased the level of teacher accountability, resulting in increased pressure to be successful in the classroom (Benedict, Thomas, Kimerling, & Leko, 2013; Derrington, 2011; Glazerman et al., 2011; Papay, 2012). As a result, several states have begun to stray from the traditional methods of evaluating teachers, thus creating their own appraisal systems in an effort to increase teacher quality and teacher accountability of student performance and success (Anderson, 2012). This approach to transform traditional teacher evaluation methods has attracted both teachers and administrators alike (Derrington, 2011). The purpose of this phenomenological narrative study was to explore teachers' perceptions regarding the influence of one southeast Texas school district's new appraisal system on classroom instruction and student issues.
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- 2015
47. Astrocytic GABA transporter 1 deficit in novel SLC6A1 variants mediated epilepsy: Connected from protein destabilization to seizures in mice and humans
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Felicia Mermer, Sarah Poliquin, Shuizhen Zhou, Xiaodong Wang, Yifeng Ding, Fei Yin, Wangzhen Shen, Juexin Wang, Kathryn Rigsby, Dong Xu, Taralynn Mack, Gerald Nwosu, Carson Flamm, Matthew Stein, and Jing-Qiong Kang
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SLC6A1 ,GABA transporter 1 (GAT-1) ,Protein misfolding ,Myoclonic atonic epilepsy (MAE) ,Endoplasmic reticulum (ER) ,Astrocytes ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Objective: Mutations in γ-aminobutyric acid (GABA) transporter 1 (GAT-1)-encoding SLC6A1 have been associated with myoclonic atonic epilepsy and other phenotypes. We determined the patho-mechanisms of the mutant GAT-1, in order to identify treatment targets. Methods: We conducted whole-exome sequencing of patients with myoclonic atonic epilepsy (MAE) and characterized the seizure phenotypes and EEG patterns. We studied the protein stability and structural changes with homology modeling and machine learning tools. We characterized the function and trafficking of the mutant GAT-1 with 3H radioactive GABA uptake assay and confocal microscopy. We utilized different models including a knockin mouse and human astrocytes derived from induced pluripotent stem cells (iPSCs). We focused on astrocytes because of their direct impact of astrocytic GAT-1 in seizures. Results: We identified four novel SLC6A1 variants associated with MAE and 2 to 4 Hz spike-wave discharges as a common EEG feature. Machine learning tools predicted that the variant proteins are destabilized. The variant protein had reduced expression and reduced GABA uptake due to endoplasmic reticular retention. The consistent observation was made in cortical and thalamic astrocytes from variant-knockin mice and human iPSC-derived astrocytes. The Slc6a+/A288V mouse, representative of MAE, had increased 5–7 Hz spike-wave discharges and absence seizures. Interpretation: SLC6A1 variants in various locations of the protein peptides can cause MAE with similar seizure phenotypes and EEG features. Reduced GABA uptake is due to decreased functional GAT-1, which, in thalamic astrocytes, could result in increased extracellular GABA accumulation and enhanced tonic inhibition, leading to seizures and abnormal EEGs.
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- 2022
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48. Cardiovascular magnetic resonance imaging in children after recovery from symptomatic COVID-19 or MIS-C: a prospective study
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Gregory Webster, Ami B. Patel, Michael R. Carr, Cynthia K. Rigsby, Karen Rychlik, Anne H. Rowley, and Joshua D. Robinson
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Pediatric ,Cardiac magnetic resonance imaging ,SARS-CoV-2 ,COVID-19 ,MIS-C ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Cardiac evaluations, including cardiovascular magnetic resonance (CMR) imaging and biomarker results, are needed in children during mid-term recovery after infection with SARS-CoV-2. The incidence of CMR abnormalities 1–3 months after recovery is over 50% in older adults and has ranged between 1 and 15% in college athletes. Abnormal cardiac biomarkers are common in adults, even during recovery. Methods We performed CMR imaging in a prospectively-recruited pediatric cohort recovered from COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We obtained CMR data and serum biomarkers. We compared these results to age-matched control patients, imaged prior to the SARS-CoV-2 pandemic. Results CMR was performed in 17 children (13.9 years, all ≤ 18 years) and 29 age-matched control patients without SARS-CoV-2 infection. Cases were recruited with symptomatic COVID-19 (11/17, 65%) or MIS-C (6/17, 35%) and studied an average of 2 months after diagnosis. All COVID-19 patients had been symptomatic with fever (73%), vomiting/diarrhea (64%), or breathing difficulty (55%) during infection. Left ventricular and right ventricular ejection fractions were indistinguishable between cases and controls (p = 0.66 and 0.70, respectively). Mean native global T1, global T2 values and segmental T2 maximum values were also not statistically different from control patients (p ≥ 0.06 for each). NT-proBNP and troponin levels were normal in all children. Conclusions Children prospectively recruited following SARS-CoV-2 infection had normal CMR and cardiac biomarker evaluations during mid-term recovery. Trial Registration Not applicable.
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- 2021
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49. Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children
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Newton, Kimberly P, Feldman, Haruna S, Chambers, Christina D, Wilson, Laura, Behling, Cynthia, Clark, Jeanne M, Molleston, Jean P, Chalasani, Naga, Sanyal, Arun J, Fishbein, Mark H, Lavine, Joel E, Schwimmer, Jeffrey B, Network, Nonalcoholic Steatohepatitis Clinical Research, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Xanthakos, Stavra, Allende, Daniela, Dasarathy, Srinivasan, McCullough, Arthur J, Pagadala, Mangesh, Pai, Rish, Winston, Cha'Ron, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Abdelmalek, Manal F, Bashir, Mustafa, Buie, Stephanie, Diehl, Anna Mae, Guy, Cynthia, Kigongo, Christopher, Malik, David, Pan, Yi-Ping, Piercy, Dawn, Kopping, Mariko, Thrasher, Tyler, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Vos, Miriam, Bozic, Molly, Cummings, Oscar W, Gawrieh, Samer, Klipsch, Ann, Ragozzino, Emily, Ragozzino, Linda, Sandrasegaran, Kumar, Subbarao, Girish, Vuppalanchi, Raj, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Whitington, Peter F, Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, Jain, Ajay, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Neuschwander-Tetri, Brent A, Torretta, Susan, Wriston, Kristina, Assadian, Fereshteh, Barone, Vanessa, Gonzalez, Maria Cardona, Davila, Jodie, Fix, Oren, Hennessey, Kelly Anne, Kowdley, Kris V, and Lopez, Kacie
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Hepatitis ,Pediatric ,Liver Disease ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Clinical Research ,Prevention ,Digestive Diseases ,Chronic Liver Disease and Cirrhosis ,2.1 Biological and endogenous factors ,Oral and gastrointestinal ,Adolescent ,Biopsy ,Birth Weight ,Child ,Cross-Sectional Studies ,Databases ,Factual ,Female ,Humans ,Infant ,Low Birth Weight ,Infant ,Postmature ,Liver ,Male ,Non-alcoholic Fatty Liver Disease ,Risk Factors ,United States ,Nonalcoholic Steatohepatitis Clinical Research Network ,birth weight ,children ,epidemiology ,nonalcoholic fatty liver disease ,nonalcoholic steatohepatitis ,obesity ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics ,Paediatrics - Abstract
ObjectivesTo examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD.Study designA multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category.ResultsChildren with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P
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- 2017
50. In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores
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Schwimmer, Jeffrey B, Lavine, Joel E, Wilson, Laura A, Neuschwander-Tetri, Brent A, Xanthakos, Stavra A, Kohli, Rohit, Barlow, Sarah E, Vos, Miriam B, Karpen, Saul J, Molleston, Jean P, Whitington, Peter F, Rosenthal, Philip, Jain, Ajay K, Murray, Karen F, Brunt, Elizabeth M, Kleiner, David E, Van Natta, Mark L, Clark, Jeanne M, Tonascia, James, Doo, Edward, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Xanthakos, Stavra, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Alazraki, Adina, Cleeton, Rebecca, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Vos, Miriam, Bozic, Molly, Cummings, Oscar W, Klipsch, Ann, Munson, Sarah, Sandrasegaran, Kumar, Subbarao, Girish, Kafka, Kimberly, Scheimann, Ann, Amsden, Katie, Fishbein, Mark H, Kirwan, Elizabeth, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Derdoy, Jose, Jain, Ajay, King, Debra, Osmack, Pat, Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Baker, Susan S, Zhu, Lixin, Africa, Jonathon, Angeles, Jorge, Arroyo, Sandra, Awai, Hannah, Behling, Cynthia, Bross, Craig, Durelle, Janis, Middleton, Michael, Newton, Kimberly, Paiz, Melissa, Sanford, Jennifer, Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Courtier, Jesse, Ferrell, Linda D, Fleck, Shannon, Gill, Ryan, Langlois, Camille, Perito, Emily Rothbaum, Tsai, Patrika, Cooper, Kara, Horslen, Simon, and Hsu, Evelyn
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Chronic Liver Disease and Cirrhosis ,Clinical Research ,Hepatitis ,Liver Disease ,Digestive Diseases ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Oral and gastrointestinal ,Adolescent ,Alanine Transaminase ,Aspartate Aminotransferases ,Biopsy ,Body Weight ,Child ,Cysteamine ,Cystine Depleting Agents ,Delayed-Action Preparations ,Double-Blind Method ,Female ,Humans ,Intention to Treat Analysis ,Liver ,Liver Cirrhosis ,Male ,Non-alcoholic Fatty Liver Disease ,Severity of Illness Index ,Pediatrics ,ALT ,AST ,Obesity ,NASH CRN ,Neurosciences ,Paediatrics and Reproductive Medicine ,Gastroenterology & Hepatology ,Clinical sciences ,Nutrition and dietetics - Abstract
Background & aimsNo treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD.MethodsWe performed a double-masked trial of 169 children with NAFLD activity scores of 4 or higher at 10 centers. From June 2012 to January 2014, the patients were assigned randomly to receive CBDR or placebo twice daily (300 mg for patients weighing ≤65 kg, 375 mg for patients weighing >65 to 80 kg, and 450 mg for patients weighing >80 kg) for 52 weeks. The primary outcome from the intention-to-treat analysis was improvement in liver histology over 52 weeks, defined as a decrease in the NAFLD activity score of 2 points or more without worsening fibrosis; patients without biopsy specimens from week 52 (17 in the CBDR group and 6 in the placebo group) were considered nonresponders. We calculated the relative risks (RR) of improvement using a stratified Cochran-Mantel-Haenszel analysis.ResultsThere was no significant difference between groups in the primary outcome (28% of children in the CBDR group vs 22% in the placebo group; RR, 1.3; 95% confidence interval [CI], 0.8-2.1; P = .34). However, children receiving CBDR had significant changes in prespecified secondary outcomes: reduced mean levels of alanine aminotransferase (reduction, 53 ± 88 U/L vs 8 ± 77 U/L in the placebo group; P = .02) and aspartate aminotransferase (reduction, 31 ± 52 vs 4 ± 36 U/L in the placebo group; P = .008), and a larger proportion had reduced lobular inflammation (36% in the CBDR group vs 21% in the placebo group; RR, 1.8; 95% CI, 1.1-2.9; P = .03). In a post hoc analysis of children weighing 65 kg or less, those taking CBDR had a 4-fold better chance of histologic improvement (observed in 50% of children in the CBDR group vs 13% in the placebo group; RR, 4.0; 95% CI, 1.3-12.3; P = .005).ConclusionsIn a randomized trial, we found that 1 year of CBDR did not reduce overall histologic markers of NAFLD compared with placebo in children. Children receiving CBDR, however, had significant reductions in serum aminotransferase levels and lobular inflammation. ClinicalTrials.gov no: NCT01529268.
- Published
- 2016
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