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531 results on '"Rigsby, Cynthia K."'

2. Pediatric Cardiovascular Magnetic Resonance Imaging

Author

Lee, Simon, Husain, Nazia, Griffin, Lindsey, Rigsby, Cynthia K., Robinson, Joshua D., Anderson, Robert H., editor, Backer, Carl L., editor, Berger, Stuart, editor, Blom, Nico A., editor, Holzer, Ralf J., editor, Robinson, Joshua D., editor, and Abdulla, Ra-id, Editor-in-Chief

Published
2024
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4. A deep learning approach to using wearable seismocardiography (SCG) for diagnosing aortic valve stenosis and predicting aortic hemodynamics obtained by 4D flow MRI

Author

Khani, Mahmoud E., Johnson, Ethan M. I., Sodhi, Aparna, Robinson, Joshua, Rigsby, Cynthia K., Allen, Bradly D., and Markl, Michael

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Electrical Engineering and Systems Science - Signal Processing
Abstract

In this paper, we explored the use of deep learning for the prediction of aortic flow metrics obtained using 4D flow MRI using wearable seismocardiography (SCG) devices. 4D flow MRI provides a comprehensive assessment of cardiovascular hemodynamics, but it is costly and time-consuming. We hypothesized that deep learning could be used to identify pathological changes in blood flow, such as elevated peak systolic velocity Vmax in patients with heart valve diseases, from SCG signals. We also investigated the ability of this deep learning technique to differentiate between patients diagnosed with aortic valve stenosis (AS), non-AS patients with a bicuspid aortic valve (BAV), non-AS patients with a mechanical aortic valve (MAV), and healthy subjects with a normal tricuspid aortic valve (TAV). In a study of 77 subjects who underwent same-day 4D flow MRI and SCG, we found that the Vmax values obtained using deep learning and SCGs were in good agreement with those obtained by 4D flow MRI. Additionally, subjects with TAV, BAV, MAV, and AS could be classified with ROC-AUC values of 92%, 95%, 81%, and 83%, respectively. This suggests that SCG obtained using low-cost wearable electronics may be used as a supplement to 4D flow MRI exams or as a screening tool for aortic valve disease., Comment: 16 pages, 4 figures

Published
2023

11. Four-dimensional Multiphase Steady-State MRI with Ferumoxytol Enhancement: Early Multicenter Feasibility in Pediatric Congenital Heart Disease.

Author

Nguyen, Kim-Lien, Ghosh, Reena M, Griffin, Lindsay M, Yoshida, Takegawa, Bedayat, Arash, Rigsby, Cynthia K, Fogel, Mark A, Whitehead, Kevin K, Hu, Peng, and Finn, J Paul

Subjects
Humans, Heart Defects, Congenital, Contrast Media, Magnetic Resonance Imaging, Prospective Studies, Feasibility Studies, Child, Child, Preschool, Infant, Female, Male, Ferrosoferric Oxide, Cardiovascular, Pediatric, Clinical Research, Biomedical Imaging, Clinical Trials and Supportive Activities, Heart Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Medical and Health Sciences, Nuclear Medicine & Medical Imaging
Abstract

Background The value of MRI in pediatric congenital heart disease (CHD) is well recognized; however, the requirement for expert oversight impedes its widespread use. Four-dimensional (4D) multiphase steady-state imaging with contrast enhancement (MUSIC) is a cardiovascular MRI technique that uses ferumoxytol and captures all anatomic features dynamically. Purpose To evaluate multicenter feasibility of 4D MUSIC MRI in pediatric CHD. Materials and Methods In this prospective study, participants with CHD underwent 4D MUSIC MRI at 3.0 T or 1.5 T between 2014 and 2020. From a pool of 460 total studies, an equal number of MRI studies from three sites (n = 60) was chosen for detailed analysis. With use of a five-point scale, the feasibility of 4D MUSIC was scored on the basis of artifacts, image quality, and diagnostic confidence for intracardiac and vascular connections (n = 780). Respiratory motion suppression was assessed by using the signal intensity profile. Bias between 4D MUSIC and two-dimensional (2D) cine imaging was evaluated by using Bland-Altman analysis; 4D MUSIC examination duration was compared with that of the local standard for CHD. Results A total of 206 participants with CHD underwent MRI at 3.0 T, and 254 participants underwent MRI at 1.5 T. Of the 60 MRI examinations chosen for analysis (20 per site; median participant age, 14.4 months [interquartile range, 2.3-49 months]; 33 female participants), 56 (93%) had good or excellent image quality scores across a spectrum of disease complexity (mean score ± standard deviation: 4.3 ± 0.6 for site 1, 4.9 ± 0.3 for site 2, and 4.6 ± 0.7 for site 3; P < .001). Artifact scores were inversely related to image quality (r = -0.88, P < .001) and respiratory motion suppression (P < .001, r = -0.45). Diagnostic confidence was high or definite in 730 of 780 (94%) intracardiac and vascular connections. The correlation between 4D MUSIC and 2D cine ventricular volumes and ejection fraction was high (range of r = 0.72-0.85; P < .001 for all). Compared with local standard MRI, 4D MUSIC reduced the image acquisition time (44 minutes ± 20 vs 12 minutes ± 3, respectively; P < .001). Conclusion Four-dimensional multiphase steady-state imaging with contrast enhancement MRI in pediatric congenital heart disease was feasible in a multicenter setting, shortened the examination time, and simplified the acquisition protocol, independently of disease complexity. Clinical trial registration no. NCT02752191 © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Roest and Lamb in this issue.

Published
2021

12. ACR Appropriateness Criteria® Congenital or Acquired Heart Disease

Author

Krishnamurthy, Rajesh, Suman, Garima, Chan, Sherwin S., Kirsch, Jacobo, Iyer, Ramesh S., Bolen, Michael A., Brown, Richard K.J., El-Sherief, Ahmed H., Galizia, Mauricio S., Hanneman, Kate, Hsu, Joe Y., de Rosen, Veronica Lenge, Rajiah, Prabhakar Shantha, Renapurkar, Rahul D., Russell, Raymond R., Samyn, Margaret, Shen, Jody, Villines, Todd C., Wall, Jessica J., Rigsby, Cynthia K., and Abbara, Suhny

Published
2023
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15. Multicenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI

Author

Nguyen, Kim-Lien, Yoshida, Takegawa, Kathuria-Prakash, Nikhita, Zaki, Islam H, Varallyay, Csanad G, Semple, Scott I, Saouaf, Rola, Rigsby, Cynthia K, Stoumpos, Sokratis, Whitehead, Kevin K, Griffin, Lindsay M, Saloner, David, Hope, Michael D, Prince, Martin R, Fogel, Mark A, Schiebler, Mark L, Roditi, Giles H, Radjenovic, Aleksandra, Newby, David E, Neuwelt, Edward A, Bashir, Mustafa R, Hu, Peng, and Finn, J Paul

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition, Patient Safety, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Contrast Media, Drug-Related Side Effects and Adverse Reactions, Female, Ferrosoferric Oxide, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Middle Aged, Off-Label Use, Registries, Medical and Health Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

Background Ferumoxytol is approved for use in the treatment of iron deficiency anemia, but it can serve as an alternative to gadolinium-based contrast agents. On the basis of postmarketing surveillance data, the Food and Drug Administration issued a black box warning regarding the risks of rare but serious acute hypersensitivity reactions during fast high-dose injection (510 mg iron in 17 seconds) for therapeutic use. Whereas single-center safety data for diagnostic use have been positive, multicenter data are lacking. Purpose To report multicenter safety data for off-label diagnostic ferumoxytol use. Materials and Methods The multicenter ferumoxytol MRI registry was established as an open-label nonrandomized surveillance databank without industry involvement. Each center monitored all ferumoxytol administrations, classified adverse events (AEs) using the National Cancer Institute Common Terminology Criteria for Adverse Events (grade 1-5), and assessed the relationship of AEs to ferumoxytol administration. AEs related to or possibly related to ferumoxytol injection were considered adverse reactions. The core laboratory adjudicated the AEs and classified them with the American College of Radiology (ACR) classification. Analysis of variance was used to compare vital signs. Results Between January 2003 and October 2018, 3215 patients (median age, 58 years; range, 1 day to 96 years; 1897 male patients) received 4240 ferumoxytol injections for MRI. Ferumoxytol dose ranged from 1 to 11 mg per kilogram of body weight (≤510 mg iron; rate ≤45 mg iron/sec). There were no systematic changes in vital signs after ferumoxytol administration (P > .05). No severe, life-threatening, or fatal AEs occurred. Eighty-three (1.9%) of 4240 AEs were related or possibly related to ferumoxytol infusions (75 mild [1.8%], eight moderate [0.2%]). Thirty-one AEs were classified as allergiclike reactions using ACR criteria but were consistent with minor infusion reactions observed with parenteral iron. Conclusion Diagnostic ferumoxytol use was well tolerated, associated with no serious adverse events, and implicated in few adverse reactions. Registry results indicate a positive safety profile for ferumoxytol use in MRI. © RSNA, 2019 Online supplemental material is available for this article.

Published
2019

16. ACR Appropriateness Criteria® Ataxia-Child

Author

Radhakrishnan, Rupa, Shea, Lindsey A.G., Pruthi, Sumit, Silvera, Victoria M., Bosemani, Thangamadhan, Desai, Nilesh K., Gilbert, Donald L., Glenn, Orit A., Guimaraes, Carolina V., Ho, Mai-Lan, Lam, H. F. Samuel, Maheshwari, Mohit, Mirsky, David M., Nadel, Helen R., Partap, Sonia, Schooler, Gary R., Udayasankar, Unni K., Whitehead, Matthew T., Wright, Jason N., and Rigsby, Cynthia K.

Published
2022
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18. ACR Appropriateness Criteria® Crohn Disease-Child

Author

Moore, Michael M., Gee, Michael S., Iyer, Ramesh S., Chan, Sherwin S., Ayers, Travis D., Bardo, Dianna M.E., Chandra, Tushar, Cooper, Matthew L., Dotson, Jennifer L., Gadepalli, Samir K., Gill, Anne E., Levin, Terry L., Nadel, Helen R., Schooler, Gary R., Shet, Narendra S., Squires, Judy H., Trout, Andrew T., Wall, Jessica J., and Rigsby, Cynthia K.

Published
2022
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27. ACR Appropriateness Criteria® Antenatal Hydronephrosis–Infant

Author

Brown, Brandon P., Simoneaux, Stephen F., Dillman, Jonathan R., Rigsby, Cynthia K., Iyer, Ramesh S., Alazraki, Adina L., Bardo, Dianna M.E., Chan, Sherwin S., Chandra, Tushar, Dorfman, Scott R., Garber, Matthew D., Moore, Michael M., Nguyen, Jie C., Peters, Craig A., Shet, Narendra S., Siegel, Alan, Waseem, Muhammad, and Karmazyn, Boaz

Published
2020
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28. ACR Appropriateness Criteria® Vomiting in Infants

Author

Alazraki, Adina L., Rigsby, Cynthia K., Iyer, Ramesh S., Bardo, Dianna M.E., Brown, Brandon P., Chan, Sherwin S., Chandra, Tushar, Dietrich, Ann, Falcone, Richard A., Jr., Garber, Matthew D., Gill, Anne E., Levin, Terry L., Moore, Michael M., Nguyen, Jie C., Shet, Narendra S., Squires, Judy H., Trout, Andrew T., and Karmazyn, Boaz

Published
2020
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29. GRASP reconstruction amplified with view‐sharing and KWIC filtering reduces underestimation of peak velocity in highly‐accelerated real‐time phase‐contrast MRI: A preliminary evaluation in pediatric patients with congenital heart disease

Author

Yang, Huili, Hong, KyungPyo, Baraboo, Justin J., Fan, Lexiaozi, Larsen, Andrine, Markl, Michael, Robinson, Joshua D., Rigsby, Cynthia K., and Kim, Daniel

Subjects
CHILD patients, VELOCITY, PULMONARY valve, MAGNETIC resonance imaging, CONGENITAL heart disease
Abstract

Purpose: To develop a highly‐accelerated, real‐time phase contrast (rtPC) MRI pulse sequence with 40 fps frame rate (25 ms effective temporal resolution). Methods: Highly‐accelerated golden‐angle radial sparse parallel (GRASP) with over regularization may result in temporal blurring, which in turn causes underestimation of peak velocity. Thus, we amplified GRASP performance by synergistically combining view‐sharing (VS) and k‐space weighted image contrast (KWIC) filtering. In 17 pediatric patients with congenital heart disease (CHD), the conventional GRASP and the proposed GRASP amplified by VS and KWIC (or GRASP + VS + KWIC) reconstruction for rtPC MRI were compared with respect to clinical standard PC MRI in measuring hemodynamic parameters (peak velocity, forward volume, backward volume, regurgitant fraction) at four locations (aortic valve, pulmonary valve, left and right pulmonary arteries). Results: The proposed reconstruction method (GRASP + VS + KWIC) achieved better effective spatial resolution (i.e., image sharpness) compared with conventional GRASP, ultimately reducing the underestimation of peak velocity from 17.4% to 6.4%. The hemodynamic metrics (peak velocity, volumes) were not significantly (p > 0.99) different between GRASP + VS + KWIC and clinical PC, whereas peak velocity was significantly (p < 0.007) lower for conventional GRASP. RtPC with GRASP + VS + KWIC also showed the ability to assess beat‐to‐beat variation and detect the highest peak among peaks. Conclusion: The synergistic combination of GRASP, VS, and KWIC achieves 25 ms effective temporal resolution (40 fps frame rate), while minimizing the underestimation of peak velocity compared with conventional GRASP. [ABSTRACT FROM AUTHOR]

Published
2024
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30. ACR Appropriateness Criteria® Pneumonia in the Immunocompetent Child

Author

Chan, Sherwin S., Kotecha, Manish K., Rigsby, Cynthia K., Iyer, Ramesh S., Alazraki, Adina L., Anupindi, Sudha A., Bardo, Dianna M.E., Brown, Brandon P., Chandra, Tushar, Dorfman, Scott R., Garber, Matthew D., Moore, Michael M., Nguyen, Jie C., Shet, Narendra S., Siegel, Alan, Valente, Jonathan H., and Karmazyn, Boaz

Published
2020
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31. GRASP reconstruction amplified with view‐sharing and KWIC filtering reduces underestimation of peak velocity in highly‐accelerated real‐time phase‐contrast MRI: A preliminary evaluation in pediatric patients with congenital heart disease

Author

Yang, Huili, primary, Hong, KyungPyo, additional, Baraboo, Justin J., additional, Fan, Lexiaozi, additional, Larsen, Andrine, additional, Markl, Michael, additional, Robinson, Joshua D., additional, Rigsby, Cynthia K., additional, and Kim, Daniel, additional

Published
2023
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32. One children’s hospital planning and development process to adhere to the FDA recommendation that babies and young children undergo thyroid function testing after receiving an injection of iodine-containing contrast media for medical imaging

Author

Bardo, Dianna M. E., primary, Samis, Jill H., additional, Josefson, Jami L., additional, Malakooti, Marcelo R., additional, Tannous, Paul, additional, Fox, Jeremy L., additional, Elhadary, Jennifer, additional, Eichstaedt, Amanda, additional, Gray, Kenneth, additional, Nytko, Agata, additional, and Rigsby, Cynthia K., additional

Published
2023
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38. ACR Appropriateness Criteria® Suspected Appendicitis-Child

Author

Koberlein, George C., Trout, Andrew T., Rigsby, Cynthia K., Iyer, Ramesh S., Alazraki, Adina L., Anupindi, Sudha A., Bardo, Dianna M.E., Brown, Brandon P., Chan, Sherwin S., Chandra, Tushar, Dillman, Jonathan R., Dorfman, Scott R., Falcone, Richard A., Jr., Garber, Matthew D., Joseph, Madeline M., Nguyen, Jie C., Safdar, Nabile M., and Karmazyn, Boaz

Published
2019
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40. Cardiac-Sparing Whole Lung IMRT in Patients With Pediatric Tumors and Lung Metastasis: Final Report of a Prospective Multicenter Clinical Trial

Author

Kalapurakal, John A., Gopalakrishnan, Mahesh, Walterhouse, David O., Rigsby, Cynthia K., Rademaker, Alfred, Helenowski, Irene, Kessel, Sandy, Morano, Karen, Laurie, Fran, Ulin, Ken, Esiashvili, Natia, Katzenstein, Howard, Marcus, Karen, Followill, David S., Wolden, Suzanne L., Mahajan, Anita, and Fitzgerald, Thomas J.

Published
2019
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50. Computed Tomography Imaging in Patients with Congenital Heart Disease Part I: Rationale and Utility. An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT): Endorsed by the Society of Pediatric Radiology (SPR) and the North American Society of Cardiac Imaging (NASCI)

Author

Han, B. Kelly, Rigsby, Cynthia K., Hlavacek, Anthony, Leipsic, Jonathon, Nicol, Edward D., Siegel, Marilyn J., Bardo, Dianna, Abbara, Suhny, Ghoshhajra, Brian, Lesser, John R., Raman, Subha, and Crean, Andrew M.

Published
2015
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