1. The prognostic significance of right paratracheal lymph node dissection numbers in right upper lobe non-small cell lung cancer.
- Author
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Zhuang, FengNian, Lin, JunPeng, Chen, WeiJie, Chen, XiaoFeng, Chen, YuJie, Wang, PeiYuan, Wang, Feng, and Liu, ShuoYan
- Abstract
Background: The number of dissected lymph nodes is closely related to the prognosis of patients with non-small cell lung cancer. This study explored the optimal number of right paratracheal lymph nodes dissected in right upper non-small cell lung cancer patients and its impact on prognosis. Methods: Patients who underwent radical surgery for right upper lobe cancer between 2012 and 2017 were retrospectively enrolled. The optimal number of right paratracheal lymph nodes and the relationship between the number of dissected right paratracheal lymph nodes and the prognosis of right upper non-small cell lung cancer were analysed. Results: A total of 241 patients were included. The optimal number of dissected right paratracheal lymph nodes was 6. The data were divided according to the number of dissected right paratracheal lymph nodes into groups RPLND + (≥ 6) and RPLND- (< 6). In the stage II and III patients, the 5-year overall survival rates were 39.0% and 48.2%, respectively (P = 0.033), and the 5-year recurrence-free survival rates were 32.8% and 41.8%, respectively (P = 0.043). Univariate and multivariate analyses revealed that among the stage II and III patients, ≥ 6 right paratracheal dissected lymph nodes was an independent prognostic factor for overall survival (HR = 0.53 95% CI 0.30–0.92 P = 0.025) and recurrence-free survival (HR = 1.94 95% CI 1.16–3.24 P = 0.011). Conclusions: Resection of 6 or more right paratracheal lymph nodes may be associated with an improved prognosis in patients with right upper non-small cell lung cancer, especially in patients with stage II or III disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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