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835 results on '"Righi E."'

3. Multi-Criteria Decision Analysis to prioritize hospital admission of patients affected by COVID-19 in low-resource settings with hospital-bed shortage

Author

Durante Mangoni, E., Florio, L.L., Zampino, R., Mele, F., Gentile, I., Pinchera, B., Coppola, N., Pisaturo, M., Luzzati, R., Petrosillo, N., Nicastri, E., Corpolongo, A., Cataldo, M.A., D’Abramo, A., Maffongelli, G., Scorzolini, L., Palazzolo, C., Boumis, E., Pan, A., D’Arminio Monforte, A., Bai, F., Antinori, S., De Rosa, F.G., Corcione, S., Lupia, T., Pinna, S.M., Scabini, S., Canta, F., Belloro, S., Bisoffi, Z., Angheben, A., Gobbi, F., Turcato, E., Ronzoni, N., Moro, L., Calabria, S., Rodari, P., Bertoli, G., Marasca, G., Puoti, M., Gori, A., Bandera, A., Mangioni, D., Rizzi, M., Castelli, F., Montineri, A., Coco, C.A., Maresca, M., Frasca, M., Aquilini, D., Vincenzi, M., Lambertenghi, L., De Rui, M.E., Razzaboni, E., Cattaneo, P., Visentin, A., Erbogasto, A., Dalla Vecchia, I., Coledan, I., Vecchi, M., Be, G., Motta, L., Zaffagnini, A., Auerbach, N., Del Bravo, P., Azzini, A.M., Righi, E., Carrara, E., Savoldi, A., Sibani, M., Lattuada, E., Carolo, G., Cordioli, M., Soldani, F., Pezzani, M.D., Avallone, S., Bruno, R., Ricciardi, A., Saggese, M.P., Malerba, G., De Nardo, Pasquale, Gentilotti, Elisa, Mazzaferri, Fulvia, Cremonini, Eleonora, Hansen, Paul, Goossens, Herman, and Tacconelli, Evelina

Published
2020
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8. Emerging treatment options for acute bacterial skin and skin structure infections: focus on intravenous delafloxacin

Author

Righi E, Carnelutti A, Vena A, and Bassetti M

Subjects
bacterial skin and skin structure infections, multidrug-resistant bacteria, methicillin-resistant Staphylococcus aureus, delafloxacin, Infectious and parasitic diseases, RC109-216
Abstract

Elda Righi, Alessia Carnelutti, Antonio Vena, Matteo Bassetti Infectious Diseases Division, Santa Maria della Misericordia University Hospital, Udine, Italy Abstract: The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), are limited. Delafloxacin is a novel fluoroquinolone available as intravenous and oral formulations and is characterized by an increased efficacy in acidic environments and activity on bacterial biofilm. Delafloxacin displays enhanced in vitro activity against MRSA, and enterococci, while maintaining efficacy against gram-negative pathogens and anaerobes. Delafloxacin has been studied for the treatment of ABSSSI and respiratory infections. Phase III studies have demonstrated noninferiority of delafloxacin compared to vancomycin, linezolid, tigecycline, and the combination of vancomycin plus aztreonam in the treatment of ABSSSI. Due to its favorable pharmacokinetic characteristics, the wide spectrum of action, and the potential for sequential therapy, delafloxacin represents a promising option in the empirical and targeted treatment of ABSSSI, both in hospital- and in community-based care. Keywords: bacterial skin and skin structure infections, multidrug-resistant bacteria, methicillin-resistant Staphylococcus aureus, delafloxacin

Published
2018

9. L-H transition studies in tritium and deuterium-tritium campaigns at JET with Be wall and W divertor

Author

Solano, E., Birkenmeier, G., Silva, C., Delabie, E., Hillesheim, J., Baciero, A., Balboa, I., Baruzzo, M., Boboc, A., Brix, M., Bernardo, J., Bourdelle, C., Carvalho, I., Carvalho, P., Challis, C., Chernyshova, M., Chomiczewska, A., Coelho, R., Coffey, I., Craciunescu, T., de la Cal, E., de la Luna, E., Dumont, R., Dumortier, P., Fontana, M., Fontdecaba, J., Frassinetti, L., Gallart, D., Garcia, J., Giroud, C., Gromelski, W., Henriques, R., Hall, J., Ho, A., Horton, L.D., Horvath, L., Jacquet, P., Jepu, I., Joffrin, E., Kappatou, A., Keeling, D., King, D., Kiptily, V., Kirov, K., Kos, D., Kowalska-Strzęciwilk, E., Lennholm, M., Lerche, E., Litherland-Smith, E., Loarte, A., Lomanowski, B., Lomas, P.J., Maggi, C.F., Mailloux, J., Mantsinen, M.J., Maslov, M., Meigs, A.G., Monakhov, I., Morales, R.B., Nielsen, Anders Henry, Nina, D., Noble, C., Pawelec, E., Poradzinski, M., Pucella, Gianluca, Puglia, P., Réfy, D., Rasmussen, Jens Juul, Righi, E., Rimini, F.G., Robinson, T., Sertoli, M., Silburn, S. A., Sips, G., Sirén, P., Štancar, Žiga, Sun, H. J., Szepesi, G., Taylor, D., Tholerus, E., Thomas, Beth, Verdoolaege, G., Vincenzi, P., Viola, Bruno, Vianello, N, Wilson, Thomas, Solano, E., Birkenmeier, G., Silva, C., Delabie, E., Hillesheim, J., Baciero, A., Balboa, I., Baruzzo, M., Boboc, A., Brix, M., Bernardo, J., Bourdelle, C., Carvalho, I., Carvalho, P., Challis, C., Chernyshova, M., Chomiczewska, A., Coelho, R., Coffey, I., Craciunescu, T., de la Cal, E., de la Luna, E., Dumont, R., Dumortier, P., Fontana, M., Fontdecaba, J., Frassinetti, L., Gallart, D., Garcia, J., Giroud, C., Gromelski, W., Henriques, R., Hall, J., Ho, A., Horton, L.D., Horvath, L., Jacquet, P., Jepu, I., Joffrin, E., Kappatou, A., Keeling, D., King, D., Kiptily, V., Kirov, K., Kos, D., Kowalska-Strzęciwilk, E., Lennholm, M., Lerche, E., Litherland-Smith, E., Loarte, A., Lomanowski, B., Lomas, P.J., Maggi, C.F., Mailloux, J., Mantsinen, M.J., Maslov, M., Meigs, A.G., Monakhov, I., Morales, R.B., Nielsen, Anders Henry, Nina, D., Noble, C., Pawelec, E., Poradzinski, M., Pucella, Gianluca, Puglia, P., Réfy, D., Rasmussen, Jens Juul, Righi, E., Rimini, F.G., Robinson, T., Sertoli, M., Silburn, S. A., Sips, G., Sirén, P., Štancar, Žiga, Sun, H. J., Szepesi, G., Taylor, D., Tholerus, E., Thomas, Beth, Verdoolaege, G., Vincenzi, P., Viola, Bruno, Vianello, N, and Wilson, Thomas

Abstract

The recent deuterium-tritium campaign in JET-ILW (DTE2) has provided a unique opportunity to study the isotope dependence of the L-H power threshold in an ITER-like wall environment (Be wall and W divertor). Here we present results from dedicated L-H transition experiments at JET-ILW, documenting the power threshold in tritium and deuterium-tritium plasmas, comparing them with the matching deuterium and hydrogen datasets. From earlier experiments in JET-ILW it is known that as plasma isotopic composition changes from deuterium, through varying deuterium/hydrogen concentrations, to pure hydrogen, the value of the line averaged density at which the threshold is minimum, n̄e,min, increases, leading us to expect that n̄e,min(T) < n̄e,min(DT) < n̄e,min(D) < n̄e,min(H). The new power threshold data confirms these expectations in most cases, with the corresponding ordering of the minimum power thresholds. We present a comparison of this data to power threshold scalings, used for extrapolation to future devices such as ITER and DEMO.

Published
2023

10. Predictors of choice of initial antifungal treatment in intraabdominal candidiasis

Author

Ansaldi, F., Scarparo, C., Diaz-Martin, A., Palacios-Garcia, I., Rosin, C., Almirante, B., Baldin, G., Vena, A., Bouza, E., de Egea, V., Tascini, C., Menichetti, F., Tagliaferri, E., Sanguinetti, M., Mesini, A., Sganga, G., Busetti, M., Pumarola, T., Martin, M.T., Nouér, S.A., Pelaez, T., Raise, E., Grandesso, S., Del Bono, V., Esteves, P., Trucchi, C., Sartor, A., De Pascale, G., Posteraro, B., Lagunes, L., Borgatta, B., Martín-Gomez, M.T., Rey-Pérez, A., Antonelli, M., Righi, E., Merelli, M., Brugnaro, P., Dimopoulos, G., Garnacho-Montero, J., Colombo, A.L., Luzzati, R., Muñoz, P., Nucci, M., Scotton, G., Viscoli, C., Tumbarello, M., Bassetti, M., and Rello, J.

Published
2016
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12. Exposure to phthalates, potential endocrine disruptors, in an infant cohort in Modena, Italy

Author

Lugli, C, Palandri, L, Ferrari, A, Barbieri, R, Trevisani, V, Passini, E, Lucaccioni, L, Facchinetti, F, and Righi, E

Subjects
phthalates, biomonitoring, Public Health, Environmental and Occupational Health, phthalates, urine, early life exposure, biomonitoring, early life exposure, urine
Abstract

Phthalates are pollutants ubiquitous in the environment. Human exposure to phthalates and their endocrine disrupting effects have been widely studied. Therefore, the European Union forbids phthalates in toys, cosmetic and kitchenware manufacturing. However, phthalate metabolites can still be found in human biological matrices. The purpose of this study is to investigate phthalate exposure over time in a group of Italian healthy newborns. In a prospective cohort study, we enlisted 187 women who gave birth in the University Hospital of Modena, Italy, between January 2019 and May 2020. Urine samples from women after delivery and from their infants at birth, 3 and 6 months were collected and 8 metabolites of 6 phthalates were analysed. Descriptive statistics were calculated and preliminary correlation coefficients tests were performed. Monoethylphthalate (MEP) was always detectable in urine samples. MEP, monomethylphthalate and diethylhexylphthalate metabolites showed an increasing trend over time, while monobutylphthalate and monobenzylphthalate showed decreasing levels over time. Associations between levels of phthalates metabolites in mother and infant pairs at birth were found for a few metabolites, while metabolites in infant samples at 3 and 6 months appeared often significantly associated. Infants’ phthalate exposure in Modena is still high and prolonged over time, even to those more toxic and strictly regulated. As phthalates presence in indoor environment can be a risk factor especially for the most fragile groups of population, such as children, public Health campaigns addressing childbearing age women should stress about the risk posed by these substances and how to avoid their exposure. Moreover, regulatory actions and a stricter legislation should be considered. Key messages • In Italy infant exposure to phthalates, including those strictly forbidden, appears still high and continuous over time. • Public heath intervention and stricter regulatory actions should be considered.

Published
2022
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13. Maternal dietary adherence during pregnancy to recommendations: a cross-sectional study in Modena

Author

De Pasquale, L, Palandri, L, Casalucci, Ma, Azzalini, D, Lucaccioni, L, Passini, E, Facchinetti, F, and Righi, E

Subjects
pregnancy, compliance, diet recommendations, diet recommendations, Public Health, Environmental and Occupational Health, pregnancy, compliance
Abstract

Background Unbalanced nutrients intake and incorrect weight gain can lead to immediate and future adverse health consequences for both mother and child. The Italian Society of Gynaecology and Obstetrics (SIGO), has drawn up a series of nutritional recommendations with the aim of promoting a correct food intake for future mothers. The purpose of our study was to assess adherence to good dietary indications during pregnancy and to evaluate if voluptuary habits could play a role. Methods This cross-sectional study investigated dietary habits during the last trimester of pregnancy. We evaluated the adherence to dietary SIGO recommendations of a sample of pregnant women representative of physiologic full-term pregnancies (n = 572, mean age 33.4±5.2) living in Modena (Italy), recruited between 2016 and 2020. Maternal diet during pregnancy was assessed by a self-administered questionnaire fill in at the hospital after childbirth, evaluating lifestyle habits and usual food intake. Descriptive statistics and bivariate associations (Chi-square tests) were performed. Results More than 50% of women did not comply with SIGO dietary recommendations. Overall, adherence was very low, ranging between 8.4% (sweets) and 38.8% (seafood), for all food categories, excluding coffee and tea (89%), alcohol (76.2%), red wine (99.1%) and seasoning (olive oil 93.4%). Preliminary results suggest that several factors and behaviours, including BMI before pregnancy, age, smoking habits, education, are associated with levels of adherence to different food categories. Conclusions Poor adherence to a proper dietary regimen during pregnancy is a missed opportunity for prevention and demonstrates the importance of promoting public health interventions to improve dietary recommendations adherence. Several initiatives, such as courses, information campaigns, use of social media and counselling can be useful for a nutrition education in pregnancy, raising awareness of the related benefits for both mother and child. Key messages • Nowadays pregnant women’s compliance to diet recommendations is still low. • There is still a lot to do in terms of education and awareness of future mothers.

Published
2022
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16. COVID-19: opinions and behavior of Italian general population during the first epidemic phase

Author

Genovese, C., La Fauci, V., Di Pietro, A., Trimarchi, G., Odone, A., Casuccio, A., Costantino, C., Restivo, V., Fantini, M., Gori, D., Azzara, A., Deiana, G., Castaldi, S., Righi, E., Palandri, L., Panciroli, G., Bianco, A., Licata, F., Cosentino, S., Mistretta, A., Marranzano, M., Ragusa, R., Gabutti, G., Stefanati, A., Prato, R., Fortunato, F., Martinelli, D., Icardi, G., Panatto, D., Amicizia, D., Fabiani, L., Moretti, A., Di Risio, D., Siliquini, R., Voglino, G., Bert, F., Lorini, C., Bonaccorsi, G., Torre, I., Pennino, F., Pavia, M., Di Giuseppe, G., Paolantonio, A., Villari, P., Marzuillo, C., Messina, G., Rivieri, C., Nante, N., Majori, S., Tardivo, S., Moretti, F., D'Amato, S., Mazzitelli, F., Giunta, I., Lo Giudice, D., Panto, G., Signorelli, C., Squeri, R., Genovese, Cristina, La Fauci, Vincenza, Di Pietro, Angela, Trimarchi, Giuseppe, Odone, Anna, Casuccio, Alessandra, Costantino, Claudio, Restivo, Vincenzo, Fantini, Mariapia, Gori, Davide, Azara, Antonio, Deiana, Giovanna, Castaldi, Silvana, Righi, Elena, Palandri, Lucia, Panciroli, Giovanni, Bianco, Aida, Licata, Francesca, Cosentino, Sofia, Mistretta, Antonio, Marranzano, Marina, Ragusa, Rosalia, Gabutti, Giovanni, Stefanati, Armando, Prato, Rosa, Fortunato, Francesca, Martinelli, Domenico, Icardi, Giancarlo, Panatto, Donatella, Amicizia, Daniela, Fabiani, Leila, Moretti, Annalucia, Di Risio, Damiana, Siliquini, Roberta, Voglino, Gianluca, Bert, Fabrizio, Lorini, Chiara, Bonaccorsi, Guglielmo, Torre, Ida, Pennino, Francesca, Pavia, Maria, Di Giuseppe, Gabriella, Paolantonio, Andrea, Villari, Paolo, Marzuillo, Carolina, Messina, Gabriele, Rivieri, Cesare, Nante, Nicola, Majori, Silvia, Tardivo, Stefano, Moretti, Francesca, D'Amato, Smeralda, Mazzitelli, Francesco, Giunta, Ioselita, Lo Giudice, Daniela, Pantò, Giuseppe, Signorelli, Carlo, Squeri, Raffaele, Genovese C., La Fauci V., Di Pietro A., Trimarchi G., Odone A., Casuccio A., Costantino C., Restivo V., Fantini M., Gori D., Azzara A., Deiana G., Castaldi S., Righi E., Palandri L., Panciroli G., Bianco A., Licata F., Cosentino S., Mistretta A., Marranzano M., Ragusa R., Gabutti G., Stefanati A., Prato R., Fortunato F., Martinelli D., Icardi G., Panatto D., Amicizia D., Fabiani L., Moretti A., Di Risio D., Siliquini R., Voglino G., Bert F., Lorini C., Bonaccorsi G., Torre I., Pennino F., Pavia M., Di Giuseppe G., Paolantonio A., Villari P., Marzuillo C., Messina G., Rivieri C., Nante N., Majori S., Tardivo S., Moretti F., D'amato S., Mazzitelli F., Giunta I., Lo Giudice D., Panto G., Signorelli C., and Squeri R.

Subjects
risk perception, Male, knowledge, SARS-CoV-2, attitude, COVID-19, perception, population, attitude, COVID-19, knowledge, perception, population, risk perception, Attitude, Humans, Female, Public Health, Epidemics, Human
Abstract

Background and aim: On January 9, 2020, the World Health Organization (WHO) declared that Chinese health authorities had identified a new coronavirus strain never before isolated in humans, the 2019-nCoV later redefined SARS-CoV-2, that still today represent a public health problem. The present survey started on 10 February 2020 with the aim of a) assessing the risk perception in healthcare workers and young students, following the evolution of attitudes, perception and knowledge over time, b) provide useful information to the general population during survey. Results: A study sample consisting of 4116 Italian in-dividuals of both sexes was enrolled. High levels of risk perception, low perception of self-efficacy and low levels of knowledge scores (24.55 ± 5.76 SD) were obtained indicating the need for continuous population monitoring as well as further communication strategies carried out at institution levels. Conclusion: The results of the present study could help public health authorities in carrying out informative campaigns for general population and could be an important tool in evaluating public knowledge and misperceptions during the management of the COVID-19. (www.actabiomedica.it).

Published
2022

20. Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A)

Author

Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, Marx, Wolf, Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, and Marx, Wolf

Published
2022

21. The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Author

Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, Berk, Michael, Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, and Berk, Michael

Published
2022

22. A regional audit system for stillbirth: a way to better understand the phenomenon

Author

Po G., Monari F., Zanni F., Grandi G., Lupi C., Facchinetti F., Mancini L., Lugli L., Lanzoni C., Sgarbi L., Chiossi C., Ricchieri F., Roberta C., Contiero R., Garani G., Pedriali M., Rossi S., Fini S., Di Bartolo M., Radi D., Vancini A., Donati A., Guadalupi E., Righetti F., Salerno A., Cocchi G., Morandi R., Gabrielli L., Graziano C., Seri M., Caprara G., Mario S. N. C., Fantuz F., Ferlini F., Righi E., Silvestrini D., Foschi F., Fieni S., Frusca T., Ferretti A., Galli L., Magnani C., Silini E., Balduzzi L., Bellini M., Rodolfi A. M., Sgarabotto M. P., Fragni G., Comitini G., Bonasoni M. P., Fioroni L., Rozzi C., Tuzio A., Vito I., Mammoliti P., De Ambrosi E., Ricci M., Bandini A., Belosi C., Muratori C., Zago S., Turci A., Vitarelli M., Po G., Monari F., Zanni F., Grandi G., Lupi C., Facchinetti F., Mancini L., Lugli L., Lanzoni C., Sgarbi L., Chiossi C., Ricchieri F., Roberta C., Contiero R., Garani G., Pedriali M., Rossi S., Fini S., Di Bartolo M., Radi D., Vancini A., Donati A., Guadalupi E., Righetti F., Salerno A., Cocchi G., Morandi R., Gabrielli L., Graziano C., Seri M., Caprara G., Mario S.N.C., Fantuz F., Ferlini F., Righi E., Silvestrini D., Foschi F., Fieni S., Frusca T., Ferretti A., Galli L., Magnani C., Silini E., Balduzzi L., Bellini M., Rodolfi A.M., Sgarabotto M.P., Fragni G., Comitini G., Bonasoni M.P., Fioroni L., Rozzi C., Tuzio A., Vito I., Mammoliti P., De Ambrosi E., Ricci M., Bandini A., Belosi C., Muratori C., Zago S., Turci A., and Vitarelli M.

Subjects
Clinical audit, Multivariate analysis, Placenta Diseases, Perinatal Death, Eastern, Umbilical Cord, Africa, Northern, Pregnancy, Risk Factors, Cause of Death, Northern, Europe, Eastern, Pregnancy Complications, Infectious, Multivariate Analysi, Causes of death, Cause of death, Fetal Growth Retardation, Obstetrics, Placenta Disease, Infectious, Obstetrics and Gynecology, Stillbirth, Perinatal audit, Quality of care, Adult, Africa South of the Sahara, Clinical Audit, Female, Fetal Death, Fetal Diseases, Humans, India, Italy, Multivariate Analysis, Pregnancy Complications, Quality of Health Care, Pregnancy Complication, Europe, Gestation, Human, Research Article, medicine.medical_specialty, Reproductive medicine, Fetal Disease, Audit, lcsh:Gynecology and obstetrics, medicine, lcsh:RG1-991, Late Stillbirth, business.industry, Risk Factor, medicine.disease, Africa, Pregnancy Complications, Infectiou, business
Abstract

Background Implementation of high-quality national audits for perinatal mortality are needed to improve the registration of all perinatal deaths and the identification of the causes of death. This study aims to evaluate the implementation of a Regional Audit System for Stillbirth in Emilia-Romagna Region, Italy. Methods For each stillbirth (≥ 22 weeks of gestation, ≥ 500 g) occurred between January 1, 2014 to December 1, 2016 (n = 332), the same diagnostic workup was performed and a clinical record with data about mother and stillborn was completed. Every case was discussed in a multidisciplinary local audit to assess both the cause of death (ReCoDe classification) and the quality of care. Data were reviewed by the Regional Audit Group. Stillbirth rates, causes of death and the quality of care were established for each case. Results Total stillbirth rate was 3.09 per 1000 births (332/107,528). Late stillbirth rate was 2.3 per 1000 (251/107,087). Sixteen stillbirths were not registered by the Regional Birth Register. The most prevalent cause of death was placental disorder (33.3%), followed by fetal (17.6%), cord (14.2%) and maternal disorders (7.6%). Unexplained cases were 14%. Compared to local audits, the regional group attributed different causes of death in 17% of cases. At multivariate analysis, infections were associated with early stillbirths (OR 3.38, CI95% 1.62–7.03) and intrapartum cases (OR 6.64, CI95% 2.61–17.02). Placental disorders were related to growth restriction (OR 1.89, CI95% 1.06–3.36) and were more frequent before term (OR 1.86, CI95% 1.11–3.15). Stillbirths judged possibly/probably preventable with a different management (10.9%) occurred more frequently in non-Italian women and were mainly related to maternal disorders (OR 6.64, CI95% 2.61–17.02). Conclusions Regional Audit System for Stillbirth improves the registration of stillbirth and allows to define the causes of death. Moreover, sub-optimal care was recognized, allowing to identify populations which could benefit from preventive measures.

Published
2019
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38. Clinical management of severe infections caused by carbapenem-resistant Gram-negative bacteria: a worldwide cross-sectional survey addressing the use of antibiotic combinations

Author

Carrara, E, Savoldi, A, Piddock, LJ, Franceschi, F, Ellis, S, Sharland, M, John Brink, A, Harris, PN, Levy-Hara, G, Rohit, A, Tsioutis, C, Zayyad, H, Giske, C, Chiamenti, M, Bragantini, D, Righi, E, and Gorska, A

Abstract

OBJECTIVES: Optimal treatment of carbapenem-resistant Gram-negative (CR-GNB) infections is uncertain due to the lack of good-quality evidence and the limited effectiveness of available antibiotics. The aim of this survey was to investigate clinicians' prescribing strategies for treating CR-GNB infections worldwide. METHODS: A 36-items-questionnaire was developed addressing the following aspects of antibiotic prescribing: respondent's background, diagnostic and therapeutic availability, preferred antibiotic strategies and rationale for selecting combination therapy. Prescribers were recruited following the snowball-sampling approach, and a post-stratification correction with inverse proportional weights was used to adjust the sample's representativeness. RESULTS: 1012 respondents from 95 countries participated in the survey. Overall, 298 (30%) of respondents had local guidelines for treating CR-GNB at their facility and 702 (71%) had access to Infectious Diseases consultation, with significant discrepancies according to country economic status: 85% (390/502) in High-Income-Countries vs 59% (194/283) in Upper-Medium-Income-Countries and 30% (118/196) in Lower-Middle-Income-Countries/Lower-Income-Countries). Targeted regimens varied widely, ranging from 40 regimens for CR-Acinetobacter spp. to more than 100 regimens for CR-Enterobacteriaceae. Although the majority of respondents acknowledged the lack of evidence behind this choice, dual combination was the preferred treatment scheme and carbapenem-polymyxin was the most prescribed regimen, irrespective of pathogen and infection source. Respondents noticeably disagreed around the meaning of 'combination therapy' with 20% (150/783) indicating the simple addition of multiple compounds, 42% (321/783) requiring the presence of in vitro activity and 38% (290/783) of in vitro-synergism. CONCLUSIONS: Management of CR-GNB infections is far from being standardized. Strategic public health focussed randomised controlled trials are urgently required to inform evidence-based treatment guidelines.

Published
2022

44. Surgical Complications Requiring an Early Relaparotomy in HIV-Infected Liver Transplant Recipients: Risk Factors and Impact on Survival

Author

Pravisani, R, Baccarani, U, Isola, M, Mocchegiani, F, Lauterio, A, Righi, E, Magistri, P, Corno, V, Adani, G, Lorenzin, D, Di Sandro, S, Pagano, D, Bassetti, M, Gruttadauria, S, De Carlis, L, Vivarelli, M, Di Benedetto, F, Risaliti, A, Pravisani R., Baccarani U., Isola M., Mocchegiani F., Lauterio A., Righi E., Magistri P., Corno V., Adani G. L., Lorenzin D., Di Sandro S., Pagano D., Bassetti M., Gruttadauria S., De Carlis L., Vivarelli M., Di Benedetto F., Risaliti A., Pravisani, R, Baccarani, U, Isola, M, Mocchegiani, F, Lauterio, A, Righi, E, Magistri, P, Corno, V, Adani, G, Lorenzin, D, Di Sandro, S, Pagano, D, Bassetti, M, Gruttadauria, S, De Carlis, L, Vivarelli, M, Di Benedetto, F, Risaliti, A, Pravisani R., Baccarani U., Isola M., Mocchegiani F., Lauterio A., Righi E., Magistri P., Corno V., Adani G. L., Lorenzin D., Di Sandro S., Pagano D., Bassetti M., Gruttadauria S., De Carlis L., Vivarelli M., Di Benedetto F., and Risaliti A.

Abstract

Aim: We aimed to analyze the risk factors for early surgical complications requiring relaparotomy and the related impact on overall survival (OS) in HIV-infected patients submitted to liver transplantation. Methods: We performed a retrospective study on a nationwide multicenter cohort of 157 HIV-infected patients submitted to liver transplantation in 6 Italian transplant units between 2004 to 2014. Results: The median preoperative model for end-stage liver disease score was 18 (interquartile range 12-26.5). An early relaparotomy was performed in 24.8% of patients, and the underlying clinical causes were biliary leak (8.2%), bleeding (8.2%), intestinal perforation (4.5%), and suspected vascular complications (3.8%). The OS at 1, 3, and 5 years was 74.3%, 68.0%, and 60.0%, respectively, and an early relaparotomy was not a prognostic factor itself, but an increasing number of relaparotomies was associated with decreased survival (hazard ratio = 1.40, 95% confidence interval [CI] 1.07-1.81, P = .01). In the multivariate analysis, preoperative refractory ascites (odds ratio 3.32, 95% CI 1.18-6.47, P = .02) and Roux-en-Y choledochojejunostomy reconstruction (odds ratio 12.712, 95% CI 2.47-65.38, P ≤ .01) were identified as significant risk factors for early relaparotomy. Conclusions: In HIV-infected liver transplant recipients, an increasing number of early relaparotomies due to surgical complications did negatively affect the OS. Preoperative refractory ascites reflecting a severe portal hypertension and a difficult biliary tract reconstruction requiring a Roux-en-Y choledochojejunostomy were associated with an increased risk of early relaparotomy.

Published
2019

45. Early post-liver transplant surgical morbidity in HIV-infected recipients: risk factor for overall survival? A nationwide retrospective study

Author

Baccarani, U, Pravisani, R, Isola, M, Mocchegiani, F, Lauterio, A, Righi, E, Magistri, P, Corno, V, Adani, G, Lorenzin, D, Di Sandro, S, Pagano, D, Bassetti, M, Gruttadauria, S, Colledan, M, De Carlis, L, Vivarelli, M, Di Benedetto, F, Risaliti, A, Baccarani U., Pravisani R., Isola M., Mocchegiani F., Lauterio A., Righi E., Magistri P., Corno V., Adani G. L., Lorenzin D., Di Sandro S., Pagano D., Bassetti M., Gruttadauria S., Colledan M., De Carlis L., Vivarelli M., Di Benedetto F., Risaliti A., Baccarani, U, Pravisani, R, Isola, M, Mocchegiani, F, Lauterio, A, Righi, E, Magistri, P, Corno, V, Adani, G, Lorenzin, D, Di Sandro, S, Pagano, D, Bassetti, M, Gruttadauria, S, Colledan, M, De Carlis, L, Vivarelli, M, Di Benedetto, F, Risaliti, A, Baccarani U., Pravisani R., Isola M., Mocchegiani F., Lauterio A., Righi E., Magistri P., Corno V., Adani G. L., Lorenzin D., Di Sandro S., Pagano D., Bassetti M., Gruttadauria S., Colledan M., De Carlis L., Vivarelli M., Di Benedetto F., and Risaliti A.

Abstract

The aim of the study was to analyse the risk factors for early surgical complications requiring relaparotomy and the related impact on overall survival (OS) in HIV-infected patients submitted to liver transplantation. Thus a retrospective investigation was conducted on a nationwide multicentre cohort of 157 HIV patients submitted to liver transplantation in six Italian Transplant Units between 2004 and 2014. An early relaparotomy was performed in 24.8% of cases and the underlying clinical causes were biliary leak (8.2%), bleeding (8.2%), intestinal perforation (4.5%) and suspect of vascular complications(3.8%). No differences in terms of prevalence for either overall or cause-specific early relaparotomies were noted when compared with a non-HIV control group, matched for MELD, recipient age, HCV-RNA positivity and HBV prevalence. While in the control group an early relaparotomy appeared a negative prognostic factor, such impact on OS was not noted in HIV recipients. Nonetheless increasing number of relaparotomies were associated with decreased survival. In multivariate analysis, preoperative refractory ascites and Roux-en-Y choledochojejunostomy reconstruction were significant risk factors for early relaparotomy. To conclude, in HIV liver transplanted patients, an increasing number of early relaparotomies because of surgical complications does negatively affect the OS. Preoperative refractory ascites reflecting a severe portal hypertension and a difficult biliary tract reconstruction requiring a Roux-en-Y choledochojejunostomy are associated with increased risk of early relaparotomy.

Published
2019

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