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1. Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial

Author

Bavendiek, Udo, Großhennig, Anika, Schwab, Johannes, Berliner, Dominik, Liu, Xiaofei, Maier, Lars, Gaspar, Thomas, Rieth, Andreas, Philipp, Sebastian, Hambrecht, Rainer, Westenfeld, Ralf, Münzel, Thomas, Winkler, Sebastian, Hülsmann, Martin, Westermann, Dirk, Zdravkovic, Marja, Lichtinghagen, Ralf, von der Leyen, Heiko, Zimmermann, Silke, Veltmann, Christian, Böhm, Michael, Störk, Stefan, Koch, Armin, and Bauersachs, Johann

Published
2023
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2. Long term safety and outcomes after atrial shunting for heart failure with preserved or mildly reduced ejection fraction: 5-year and 3-year follow-up in the REDUCE LAP-HF I and II trials

Author

Litwin, Sheldon E., Komtebedde, Jan, Borlaug, Barry A., Kaye, David M., Hasenfuβ, Gerd, Kawash, Rami, Hoendermis, Elke, Hummel, Scott L., Cikes, Maja, Gustafsson, Finn, Chung, Eugene S., Mohan, Rajeev C., Sverdlov, Aaron L., Swarup, Vijendra, Winkler, Sebastian, Hayward, Christopher S., Bergmann, Martin W., Bugger, Heiko, McKenzie, Scott, Nair, Ajith, Rieth, Andreas, Burkhoff, Daniel, Cutlip, Donald E., Solomon, Scott D., van Veldhuisen, Dirk J., Leon, Martin B., and Shah, Sanjiv J.

Published
2024
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6. Pathophysiologie des Schocks

Author

Rieth, Andreas, Boeken, Udo, editor, Assmann, Alexander, editor, Klotz, Stefan, editor, Born, Frank, editor, Rieth, Andreas, editor, and Schmid, Christof, editor

Published
2020
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8. Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction

Author

Patel, Ravi B., primary, Silvestry, Frank E., additional, Komtebedde, Jan, additional, Solomon, Scott D., additional, Hasenfuß, Gerd, additional, Litwin, Sheldon E., additional, Borlaug, Barry A., additional, Price, Matthew J., additional, Kawash, Rami, additional, Hummel, Scott L., additional, Cutlip, Donald E., additional, Leon, Martin B., additional, van Veldhuisen, Dirk J., additional, Rieth, Andreas J., additional, McKenzie, Scott, additional, Bugger, Heiko, additional, Mazurek, Jeremy A., additional, Kapadia, Samir R., additional, Vanderheyden, Marc, additional, Ky, Bonnie, additional, and Shah, Sanjiv J., additional

Published
2024
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11. Pulmonale Hypertonie assoziiert mit Linksherzerkrankungen (Gruppe 2)

Author

Schmidt, Kai Helge, additional, Bikou, Olympia, additional, Blindt, Rüdiger, additional, Bruch, Leonhard, additional, Felgendreher, Ralf, additional, Hohenforst-Schmidt, Wolfgang, additional, Holt, Stephan, additional, Ladage, Dennis, additional, Pfeuffer-Jovic, Elena, additional, Rieth, Andreas, additional, Schmeisser, Alexander, additional, Schnitzler, Katharina, additional, Stadler, Stefan, additional, Steringer-Mascherbauer, Regina, additional, Yogeswaran, Athiththan, additional, and Kuebler, Wolfgang M., additional

Published
2023
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12. COVID-19 among heart transplant recipients in Germany: a multicenter survey

Author

Rivinius, Rasmus, Kaya, Ziya, Schramm, René, Boeken, Udo, Provaznik, Zdenek, Heim, Christian, Knosalla, Christoph, Schoenrath, Felix, Rieth, Andreas, Berchtold-Herz, Michael, Barten, Markus J., Rauschning, Dominic, Mücke, Victoria T., Heyl, Stephan, Pistulli, Rudin, Grinninger, Carola, Hagl, Christian, Gummert, Jan F., Warnecke, Gregor, Schulze, P. Christian, Katus, Hugo A., Kreusser, Michael M., and Raake, Philip W.

Published
2020
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14. Echocardiographic pressure–strain loop‐derived stroke work of the right ventricle: validation against the gold standard

Author

Richter, Manuel J., primary, Douschan, Philipp, additional, Fortuni, Federico, additional, Gall, Henning, additional, Ghofrani, Hossein A., additional, Keranov, Stanislav, additional, Kremer, Nils, additional, Kriechbaum, Steffen D., additional, Rako, Zvonimir A., additional, Rieth, Andreas J., additional, da Rocha, Bruno Brito, additional, Seeger, Werner, additional, Zedler, Daniel, additional, Yildiz, Selin, additional, Yogeswaran, Athiththan, additional, and Tello, Khodr, additional

Published
2023
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15. Native T2 Predicts Myocardial Inflammation Irrespective of a Patient’s Volume Status

Author

Wolter, Jan Sebastian, primary, Treiber, Julia M., additional, Fischer, Selina, additional, Fischer-Rasokat, Ulrich, additional, Kriechbaum, Steffen D., additional, Rieth, Andreas, additional, Weferling, Maren, additional, von Jeinsen, Beatrice, additional, Hain, Andreas, additional, Hamm, Christian W., additional, Keller, Till, additional, and Rolf, Andreas, additional

Published
2023
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16. Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy

Author

Pölzl, Gerhard, Altenberger, Johann, Baholli, Loant, Beltrán, Paola, Borbély, Attila, Comin-Colet, Josep, Delgado, Juan F., Fedele, Francesco, Fontana, Antonella, Fruhwald, Friedrich, Giamouzis, Gregory, Giannakoulas, George, Garcia-González, Martín J., Gustafsson, Finn, Kaikkonen, Kari, Kivikko, Matti, Kubica, Jacek, von Lewinski, Dirk, Löfman, Ida, Malfatto, Gabriella, Manito, Nicolás, Martínez-Sellés, Martin, Masip, Josep, Merkely, Bela, Morandi, Fabrizio, Mølgaard, Henning, Oliva, Fabrizio, Pantev, Emil, Papp, Zoltán, Perna, Gian Piero, Pfister, Roman, Piazza, Vito, Bover, Ramón, Rangel-Sousa, Diego, Recio-Mayoral, Alejandro, Reinecke, Alexander, Rieth, Andreas, Sarapohja, Toni, Schmidt, Gunter, Seidel, Mirko, Störk, Stefan, Vrtovec, Bojan, Wikström, Gerhard, Yerly, Patrik, and Pollesello, Piero

Published
2017
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19. Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure

Author

Borlaug, Barry A., Blair, John, Bergmann, Martin W., Bugger, Heiko, Burkhoff, Dan, Bruch, Leonhard, Celermajer, David S., Claggett, Brian, Cleland, John G. F., Cutlip, Donald E., Dauber, Ira, Eicher, Jean-Christophe, Gao, Qi, Gorter, Thomas M., Gustafsson, Finn, Hayward, Chris, Van der Heyden, Jan, Hasenfuß, Gerd, Hummel, Scott L., Kaye, David M., Komtebedde, Jan, Massaro, Joseph M., Mazurek, Jeremy A., McKenzie, Scott, Mehta, Shamir R., Petrie, Mark C., Post, Marco C., Nair, Ajith, Rieth, Andreas, Silvestry, Frank E., Solomon, Scott D., Trochu, Jean-Noël, Veldhuisen, Dirk J. Van, Westenfeld, Ralf, Leon, Martin B., Shah, Sanjiv J., and Cardiovascular Centre (CVC)

Subjects
Male, Cardiac Catheterization, Pulmonary Circulation, hypertension, pulmonary, hypertension, pulmonary, heart failure, EXERCISE, PRESSURE, Article, Physiology (medical), therapeutics, Humans, Heart Atria, lung diseases, OUTCOMES, REST, Stroke Volume, clinical trial, TIME, Treatment Outcome, PRESERVED EJECTION FRACTION, Female, vascular diseases, Cardiology and Cardiovascular Medicine, INTERATRIAL SHUNT
Abstract

Background: In REDUCE LAP-HF II (A Study to Evaluate the Corvia Medical, Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients With Heart Failure), implantation of an atrial shunt device did not provide overall clinical benefit for patients with heart failure with preserved or mildly reduced ejection fraction. However, prespecified analyses identified differences in response in subgroups defined by pulmonary artery systolic pressure during submaximal exercise, right atrial volume, and sex. Shunt implantation reduces left atrial pressures but increases pulmonary blood flow, which may be poorly tolerated in patients with pulmonary vascular disease (PVD). On the basis of these results, we hypothesized that patients with latent PVD, defined as elevated pulmonary vascular resistance during exercise, might be harmed by shunt implantation, and conversely that patients without PVD might benefit. Methods: REDUCE LAP-HF II enrolled 626 patients with heart failure, ejection fraction ≥40%, exercise pulmonary capillary wedge pressure ≥25 mm Hg, and resting pulmonary vascular resistance Results: Compared with patients without PVD (n=382), those with latent PVD (n=188) were older, had more atrial fibrillation and right heart dysfunction, and were more likely to have elevated left atrial pressure at rest. Shunt treatment was associated with worse outcomes in patients with PVD (win ratio, 0.60 [95% CI, 0.42, 0.86]; P =0.005) and signal of clinical benefit in patients without PVD (win ratio, 1.31 [95% CI, 1.02, 1.68]; P =0.038). Patients with larger right atrial volumes and men had worse outcomes with the device and both groups were more likely to have pacemakers, heart failure with mildly reduced ejection fraction, and increased left atrial volume. For patients without latent PVD or pacemaker (n=313; 50% of randomized patients), shunt treatment resulted in more robust signal of clinical benefit (win ratio, 1.51 [95% CI, 1.14, 2.00]; P =0.004). Conclusions: In patients with heart failure with preserved or mildly reduced ejection fraction, the presence of latent PVD uncovered by invasive hemodynamic exercise testing identifies patients who may worsen with atrial shunt therapy, whereas those without latent PVD may benefit.

Published
2022

20. Exercise MR-proANP unmasks latent right heart failure in CTEPH

Author

Kriechbaum, Steffen D., primary, Birmes, Judith, additional, Wiedenroth, Christoph B., additional, Adameit, Miriam S.D., additional, Gruen, Dimitri, additional, Vietheer, J., additional, Richter, Manuel J., additional, Guth, Stefan, additional, Roller, Fritz C., additional, Rademann, Matthias, additional, Fischer-Rasokat, Ulrich, additional, Rolf, Andreas, additional, Liebetrau, Christoph, additional, Hamm, Christian W., additional, Keller, Till, additional, and Rieth, Andreas J., additional

Published
2022
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21. Hemodynamic markers of pulmonary vasculopathy for prediction of early right heart failure and mortality after heart transplantation

Author

Rieth, Andreas J., primary, Rivinius, Rasmus, additional, Lühring, Tom, additional, Grün, Dimitri, additional, Keller, Till, additional, Grinninger, Carola, additional, Schüttler, Dominik, additional, Bara, Christoph L., additional, Helmschrott, Matthias, additional, Frey, Norbert, additional, Sandhaus, Tim, additional, Schulze, Christian, additional, Kriechbaum, Steffen, additional, Vietheer, Julia, additional, Sindermann, Jürgen, additional, Welp, Henryk, additional, Lichtenberg, Artur, additional, Choi, Yeong-Hoon, additional, Richter, Manfred, additional, Tello, Khodr, additional, Richter, Manuel J., additional, Hamm, Christian W., additional, and Boeken, Udo, additional

Published
2022
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22. Right ventricular–pulmonary arterial coupling and its relationship to exercise haemodynamics in a continuum of patients with pulmonary vascular disease due to chronic thromboembolism

Author

Douschan, Philipp, primary, Tello, Khodr, additional, Rieth, Andreas J., additional, Wiedenroth, Christoph B., additional, Sassmann, Teresa, additional, Kovacs, Gabor, additional, Ghofrani, Hossein A., additional, Seeger, Werner, additional, Richter, Manuel, additional, and Guth, Stefan, additional

Published
2022
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23. Implantation mechanischer Unterstützungssysteme und Herztransplantation bei Patienten mit terminaler Herzinsuffizienz

Author

Schulze, P. Christian, primary, Barten, Markus J., additional, Boeken, Udo, additional, Färber, Gloria, additional, Hagl, Christian M., additional, Jung, Christian, additional, Leistner, David, additional, Potapov, Evgenij, additional, Bauersachs, Johann, additional, Raake, Philip, additional, Reiss, Nils, additional, Saeed, Diyar, additional, Schibilsky, David, additional, Störk, Stefan, additional, Veltmann, Christian, additional, Rieth, Andreas J., additional, and Gummert, Jan, additional

Published
2022
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24. Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension

Author

Rieth, Andreas J., Gruen, Dimitri, Zarogiannis, Georgios, Kriechbaum, Steffen D., Wolter, Sebastian, Richter, Manuel J., Tello, Khodr, Krueger, Ulrich, Mitrovic, Veselin, Rosenkranz, Stephan, Hamm, Christian W., Keller, Till, Rieth, Andreas J., Gruen, Dimitri, Zarogiannis, Georgios, Kriechbaum, Steffen D., Wolter, Sebastian, Richter, Manuel J., Tello, Khodr, Krueger, Ulrich, Mitrovic, Veselin, Rosenkranz, Stephan, Hamm, Christian W., and Keller, Till

Abstract

BackgroundPulmonary hypertension (PH) is an established risk factor in patients with heart failure (HF). However, right heart catheterisation (RHC) and vasoreactivity testing (VRT) are not routinely recommended in these patients. MethodsThe primary objective of the present study was to explore the impact of VRT using sublingual glyceryl trinitrate (GTN) on transplant/ventricular assist device-free survival in HF patients with post-capillary PH. RHC parameters were correlated retrospectively with the primary outcome. ResultsThe cohort comprised 154 HF patients with post-capillary PH undergoing RHC with GTN-VRT at a tertiary heart failure centre. Multiple parameters were associated with survival. After adjustment for established prognosis-relevant clinical variables from the MAGGIC Score, variables with the most relevant odds ratios (OR) obtained after GTN-VRT were: calculated effective pulmonary arterial (PA) elastance (adjusted OR 2.26, 95%CI 1.30-3.92; p = 0.004), PA compliance (PAC-GTN; adjusted OR 0.45, 95%CI 0.25-0.80; p = 0.006), and total pulmonary resistance (adjusted OR 2.29, 95%CI 1.34-3.93; p = 0.003). Forest plot analysis including these three variables as well as PAC at baseline, delta PAC, and the presence of combined post- and pre-capillary PH revealed prognostic superiority of PAC-GTN, which was confirmed by Kaplan-Meier analysis. ConclusionsIn our cohort of symptomatic HF patients with post-capillary PH, improved PAC after administration of GTN was associated with survival independent of established hemodynamic and clinical risk factors. VRT using GTN may be better described as unloading test due to GTN's complex effects on the circulation. This could be used for advanced prognostication and should be investigated in further studies.

Published
2022

25. A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure-volume loops

Author

Richter, Manuel Jonas, Yogeswaran, Athiththan, Husain-Syed, Faeq, Vadász, István, Rako, Zvonimir, Mohajerani, Emad, Ghofrani, Hossein Ardeschir, Naeije, Robert, Seeger, Werner, Herberg, Ulrike, Rieth, Andreas, Tedford, Ryan R.J., Grimminger, Friedrich, Gall, H., Tello, Khodr, Richter, Manuel Jonas, Yogeswaran, Athiththan, Husain-Syed, Faeq, Vadász, István, Rako, Zvonimir, Mohajerani, Emad, Ghofrani, Hossein Ardeschir, Naeije, Robert, Seeger, Werner, Herberg, Ulrike, Rieth, Andreas, Tedford, Ryan R.J., Grimminger, Friedrich, Gall, H., and Tello, Khodr

Abstract

Aims: We sought to assess the feasibility of constructing right ventricular (RV) pressure-volume (PV) loops solely by echocardiography. Methods and results: We performed RV conductance and pressure wire (PW) catheterization with simultaneous echocardiography in 35 patients with pulmonary hypertension. To generate echocardiographic PV loops, a reference RV pressure curve was constructed using pooled PW data from the first 20 patients (initial cohort). Individual pressure curves were then generated by adjusting the reference curve according to RV isovolumic and ejection phase duration and estimated RV systolic pressure. The pressure curves were synchronized with echocardiographic volume curves. We validated the reference curve in the remaining 15 patients (validation cohort). Methods were compared with correlation and Bland-Altman analysis. In the initial cohort, echocardiographic and conductance-derived PV loop parameters were significantly correlated {rho = 0.8053 [end-systolic elastance (Ees)], 0.8261 [Ees/arterial elastance (Ea)], and 0.697 (stroke work); all P < 0.001}, with low bias [-0.016 mmHg/mL (Ees), 0.1225 (Ees/Ea), and -39.0 mmHg mL (stroke work)] and acceptable limits of agreement. Echocardiographic and PW-derived Ees were also tightly correlated, with low bias (-0.009 mmHg/mL) and small limits of agreement. Echocardiographic and conductance-derived Ees, Ees/Ea, and stroke work were also tightly correlated in the validation cohort (rho = 0.9014, 0.9812, and 0.9491, respectively; all P < 0.001), with low bias (0.0173 mmHg/mL, 0.0153, and 255.1 mmHg mL, respectively) and acceptable limits. Conclusion: The novel echocardiographic method is an acceptable alternative to invasively measured PV loops to assess contractility, RV-arterial coupling, and RV myocardial work. Further validation is warranted., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2022

26. Hemodynamic markers of pulmonary vasculopathy for prediction of early right heart failure and mortality after heart transplantation.

Author

Rieth, Andreas J., Rivinius, Rasmus, Lühring, Tom, Grün, Dimitri, Keller, Till, Grinninger, Carola, Schüttler, Dominik, Bara, Christoph L., Helmschrott, Matthias, Frey, Norbert, Sandhaus, Tim, Schulze, Christian, Kriechbaum, Steffen, Vietheer, Julia, Sindermann, Jürgen, Welp, Henryk, Lichtenberg, Artur, Choi, Yeong-Hoon, Richter, Manfred, and Tello, Khodr

Subjects
*HEART transplantation, *HEART failure, *HEMODYNAMICS, *DISEASE risk factors, MORTALITY risk factors
Abstract

Elevated pulmonary vascular resistance (PVR) is broadly accepted as an imminent risk factor for mortality after heart transplantation (HTx). However, no current HTx recipient risk score includes PVR or other hemodynamic parameters. This study examined the utility of various hemodynamic parameters for risk stratification in a contemporary HTx population. Patients from seven German HTx centers undergoing HTx between 2011 and 2015 were included retrospectively. Established risk factors and complete hemodynamic datasets before HTx were analyzed. Outcome measures were overall all-cause mortality, 12-month mortality, and right heart failure (RHF) after HTx. The final analysis included 333 patients (28% female) with a median age of 54 (IQR 46-60) years. The median mean pulmonary artery pressure was 30 (IQR 23-38) mm Hg, transpulmonary gradient 8 (IQR 5-10) mm Hg, and PVR 2.1 (IQR 1.5-2.9) Wood units. Overall mortality was 35.7%, 12-month mortality was 23.7%, and the incidence of early RHF was 22.8%, which was significantly associated with overall mortality (log-rank HR 4.11, 95% CI 2.47-6.84; log-rank p <.0001). Pulmonary arterial elastance (Ea) was associated with overall mortality (HR 1.74, 95% CI 1.25-2.30; p <.001) independent of other non-hemodynamic risk factors. Ea values below a calculated cutoff represented a significantly reduced mortality risk (HR 0.38, 95% CI 0.19-0.76; p <.0001). PVR with the established cutoff of 3.0 WU was not significant. Ea was also significantly associated with 12-month mortality and RHF. Ea showed a strong impact on post-transplant mortality and RHF and should become part of the routine hemodynamic evaluation in HTx candidates. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension

Author

Rieth, Andreas J., primary, Grün, Dimitri, additional, Zarogiannis, Georgios, additional, Kriechbaum, Steffen D., additional, Wolter, Sebastian, additional, Richter, Manuel J., additional, Tello, Khodr, additional, Krüger, Ulrich, additional, Mitrovic, Veselin, additional, Rosenkranz, Stephan, additional, Hamm, Christian W., additional, and Keller, Till, additional

Published
2022
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28. CILP1 as a biomarker for right ventricular dysfunction in patients with ischemic cardiomyopathy

Author

Keranov, Stanislav, primary, Jafari, Leili, additional, Haen, Saskia, additional, Vietheer, Julia, additional, Kriechbaum, Steffen, additional, Dörr, Oliver, additional, Liebetrau, Christoph, additional, Troidl, Christian, additional, Rutsatz, Wiebke, additional, Rieth, Andreas, additional, Hamm, Christian W., additional, Nef, Holger, additional, Rolf, Andreas, additional, and Keller, Till, additional

Published
2022
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29. Unmasking right ventricular-arterial uncoupling during fluid challenge in pulmonary hypertension

Author

Kremer, Nils, primary, Rako, Zvonimir, additional, Douschan, Philipp, additional, Gall, Henning, additional, Ghofrani, Hossein A., additional, Grimminger, Friedrich, additional, Guth, Stefan, additional, Naeije, Robert, additional, Rieth, Andreas, additional, Schulz, Rainer, additional, Seeger, Werner, additional, Tedford, Ryan J., additional, Vadász, István, additional, Vanderpool, Rebecca, additional, Wiedenroth, Christoph B., additional, Richter, Manuel J., additional, and Tello, Khodr, additional

Published
2022
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30. Herzinsuffizienzprotektion bei Patienten mit Diabetes mellitus Typ 2 durch SGLT2-Inhibitoren – Evidenzlage und mögliche Mechanismen

Author

Rieth, Andreas J., Hamm, Christian W., Wanner, Christoph, Mitrovic, Veselin, and Keller, Till

Subjects
Heart Failure, Übersichten, Kardioprotektiver Effekt, Empagliflozin, Cardioprotective effect, Blood Pressure, Kardiorenale Interaktion, Dapagliflozin, Diabetes Mellitus, Type 2, Cardiorenal interaction, Humans, Hypoglycemic Agents, Canagliflozin, Sodium-Glucose Transporter 2 Inhibitors
Abstract

Renal sodium-glucose cotransporter‑2 (SGLT2) inhibitors seem to have a cardioprotective effect beyond the antidiabetic effect. The underlying mechanisms are unclear.Selective search in PubMed with a focus on heart failure endpoints and possible mechanisms of action.During treatment with three of the substances analyzed, there were fewer hospitalizations for heart failure compared with placebo; however, the numbers needed to treat within the primary analyses were relatively high (72-117). We found that loss of weight and lowering of blood pressure were more pronounced during treatment with verum than with placebo and an association of the preventive effect with more severely impaired renal function.The SGLT2 inhibitors show a moderate heart failure protective effect in diabetic patients. It is likely that a nephroprotective effect with modulation of the cardiorenal interaction is an important part of the mechanism of action but this must be substantiated in further investigations.HINTERGRUND: Hemmstoffe des renalen Natrium-Glukose-Kotransporters 2 („sodium glucose-linked transporter 2“; SGLT2i) scheinen außer der antidiabetischen auch eine kardioprotektive Wirkung zu besitzen; deren Mechanismus ist jedoch unklar.Selektive Literaturrecherche in PubMed (Fokus Herzinsuffizienz und Wirkmechanismen).Unter Therapie mit 3 der untersuchten Substanzen kam es im Vergleich mit Placebo zu weniger herzinsuffizienzbedingten Krankenhausaufenthalten, allerdings mit einer relativ hohen Anzahl von Behandlungen pro verhindertes Ereignis (72–117). Außer einer stärkeren Gewichtsabnahme und Blutdrucksenkung unter dem Verum gegenüber Placebo fiel eine Zunahme des kardioprotektiven Effekts bei stärker eingeschränkter Nierenfunktion auf.Ein moderater herzinsuffizienzpräventiver Effekt von Hemmstoffen des renalen SGLT2 kann bei Diabetikern als gesichert gelten. Ein wesentlicher Wirkmechanismus beruht wahrscheinlich auf einem nephroprotektiven Effekt mit Modulation der kardiorenalen Interaktion, was jedoch weiterer Abklärung bedarf.

Published
2020

32. Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy

Author

Keranov, Stanislav, primary, Haen, Saskia, additional, Vietheer, Julia, additional, Rutsatz, Wiebke, additional, Wolter, Jan-Sebastian, additional, Kriechbaum, Steffen D., additional, von Jeinsen, Beatrice, additional, Bauer, Pascal, additional, Tello, Khodr, additional, Richter, Manuel, additional, Dörr, Oliver, additional, Rieth, Andreas J., additional, Nef, Holger, additional, Hamm, Christian W., additional, Liebetrau, Christoph, additional, Rolf, Andreas, additional, and Keller, Till, additional

Published
2021
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33. Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair

Author

Rieth, Andreas J., primary, Kriechbaum, Steffen D., additional, Richter, Manuel J., additional, Wenninger, Elena, additional, Fischer-Rasokat, Ulrich, additional, Tello, Khodr, additional, Gall, Henning, additional, Ghofrani, Hossein A., additional, Guth, Stefan, additional, Wiedenroth, Christoph B., additional, Mitrovic, Veselin, additional, Hamm, Christian W., additional, Liebetrau, Christoph, additional, and Walther, Claudia, additional

Published
2021
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35. Exercise hemodynamics in heart failure patients with preserved and mid-range ejection fraction: key role of the right heart

Author

Rieth, Andreas J., primary, Richter, Manuel J., additional, Tello, Khodr, additional, Gall, Henning, additional, Ghofrani, Hossein A., additional, Guth, Stefan, additional, Wiedenroth, Christoph B., additional, Seeger, Werner, additional, Kriechbaum, Steffen D., additional, Mitrovic, Veselin, additional, Schulze, P. Christian, additional, and Hamm, Christian W., additional

Published
2021
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38. Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy

Author

Keranov, Stanislav, Haen, Saskia, Vierheer, Julia-Mareen, Rutsatz, Wiebke, Wolter, Jan Sebastian, Kriechbaum, Steffen D., Jeinsen, Beatrice von, Bauer, Pascal, Tello, Khodr, Richter, Manuel Jonas, Dörr, Oliver, Rieth, Andreas, Nef, Holger, Hamm, Christian, Liebetrau, Christoph, Rolf, Andreas, Keller, Till, and Justus Liebig University Giessen

Subjects
ddc:610
Published
2021
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39. A novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure–volume loops

Author

Richter, Manuel J, primary, Yogeswaran, Athiththan, additional, Husain-Syed, Faeq, additional, Vadász, István, additional, Rako, Zvonimir, additional, Mohajerani, Emad, additional, Ghofrani, Hossein A, additional, Naeije, Robert, additional, Seeger, Werner, additional, Herberg, Ulrike, additional, Rieth, Andreas, additional, Tedford, Ryan J, additional, Grimminger, Friedrich, additional, Gall, Henning, additional, and Tello, Khodr, additional

Published
2021
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41. Exercise right heart catheterization before and after balloon pulmonary angioplasty in inoperable patients with chronic thromboembolic pulmonary hypertension

Author

Wiedenroth, Christoph B., Rieth, Andreas J., Kriechbaum, Steffen, Ghofrani, H.- Ardeschir, Breithecker, Andreas, Haas, Moritz, Roller, Fritz, Richter, Manuel J., Lankeit, Mareike, Mielzarek, Lisa, Rolf, Andreas, Hamm, Christian W., Mayer, Eckhard, Guth, Stefan, Liebetrau, Christoph, Wiedenroth, Christoph B., Rieth, Andreas J., Kriechbaum, Steffen, Ghofrani, H.- Ardeschir, Breithecker, Andreas, Haas, Moritz, Roller, Fritz, Richter, Manuel J., Lankeit, Mareike, Mielzarek, Lisa, Rolf, Andreas, Hamm, Christian W., Mayer, Eckhard, Guth, Stefan, and Liebetrau, Christoph

Abstract

Background: Balloon pulmonary angioplasty is an evolving, interventional treatment option for inoperable patients with chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary hypertension at rest as well as exercise capacity is considered to be relevant outcome parameters. The aim of the present study was to determine whether measurement of pulmonary hemodynamics during exercise before and six months after balloon pulmonary angioplasty have an added value. Methods: From March 2014 to July 2018, 172 consecutive patients underwent balloon pulmonary angioplasty. Of these, 64 consecutive patients with inoperable CTEPH underwent a comprehensive diagnostic workup that included right heart catheterization at rest and during exercise before balloon pulmonary angioplasty treatments and six months after the last intervention. Results: Improvements in pulmonary hemodynamics at rest and during exercise, in quality of life, and in exercise capacity were observed six months after balloon pulmonary angioplasty: WHO functional class improved in 78% of patients. The mean pulmonary arterial pressure (mPAP) at rest was reduced from 41 ± 9 to 31 ± 9 mmHg (p < 0.0001). The mPAP/cardiac output slope decreased after balloon pulmonary angioplasty (11.2 ± 25.6 WU to 7.7 ± 4.1 WU; p < 0.0001), and correlated with N-terminal fragment of pro-brain natriuretic peptide (p = 0.035) and 6-minute walking distance (p = 0.01). Conclusions: Exercise right heart catheterization provides valuable information on the changes of pulmonary hemodynamics after balloon pulmonary angioplasty in inoperable CTEPH patients that are not obtainable by measuring resting hemodynamics.

Published
2020

43. Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology

Author

Skrahina, Volha, primary, Grittner, Ulrike, additional, Beetz, Christian, additional, Skripuletz, Thomas, additional, Juenemann, Martin, additional, Krämer, Heidrun H., additional, Hahn, Katrin, additional, Rieth, Andreas, additional, Schaechinger, Volker, additional, Patten, Monica, additional, Tanislav, Christian, additional, Achenbach, Stephan, additional, Assmus, Birgit, additional, Knebel, Fabian, additional, Gingele, Stefan, additional, Skrahin, Aliaksandr, additional, Hartkamp, Jörg, additional, Förster, Toni M., additional, Roesner, Sabine, additional, Pereira, Catarina, additional, and Rolfs, Arndt, additional

Published
2021
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44. novel non-invasive and echocardiography-derived method for quantification of right ventricular pressure–volume loops.

Author

Richter, Manuel J, Yogeswaran, Athiththan, Husain-Syed, Faeq, Vadász, István, Rako, Zvonimir, Mohajerani, Emad, Ghofrani, Hossein A, Naeije, Robert, Seeger, Werner, Herberg, Ulrike, Rieth, Andreas, Tedford, Ryan J, Grimminger, Friedrich, Gall, Henning, and Tello, Khodr

Subjects
ECHOCARDIOGRAPHY, BLOOD pressure, RIGHT heart ventricle, PULMONARY hypertension, MANN Whitney U Test, HEART ventricles, T-test (Statistics), DESCRIPTIVE statistics, RESEARCH funding, HEART physiology, LONGITUDINAL method
Abstract

Aims We sought to assess the feasibility of constructing right ventricular (RV) pressure–volume (PV) loops solely by echocardiography. Methods and results We performed RV conductance and pressure wire (PW) catheterization with simultaneous echocardiography in 35 patients with pulmonary hypertension. To generate echocardiographic PV loops, a reference RV pressure curve was constructed using pooled PW data from the first 20 patients (initial cohort). Individual pressure curves were then generated by adjusting the reference curve according to RV isovolumic and ejection phase duration and estimated RV systolic pressure. The pressure curves were synchronized with echocardiographic volume curves. We validated the reference curve in the remaining 15 patients (validation cohort). Methods were compared with correlation and Bland–Altman analysis. In the initial cohort, echocardiographic and conductance-derived PV loop parameters were significantly correlated {rho = 0.8053 [end-systolic elastance (Ees)], 0.8261 [Ees/arterial elastance (Ea)], and 0.697 (stroke work); all P  <   0.001}, with low bias [−0.016 mmHg/mL (Ees), 0.1225 (Ees/Ea), and −39.0 mmHg mL (stroke work)] and acceptable limits of agreement. Echocardiographic and PW-derived Ees were also tightly correlated, with low bias (−0.009 mmHg/mL) and small limits of agreement. Echocardiographic and conductance-derived Ees, Ees/Ea, and stroke work were also tightly correlated in the validation cohort (rho = 0.9014, 0.9812, and 0.9491, respectively; all P  <   0.001), with low bias (0.0173 mmHg/mL, 0.0153, and 255.1 mmHg mL, respectively) and acceptable limits. Conclusion The novel echocardiographic method is an acceptable alternative to invasively measured PV loops to assess contractility, RV-arterial coupling, and RV myocardial work. Further validation is warranted. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension

Author

Kriechbaum, Steffen D., primary, Wiedenroth, Christoph B., additional, Peters, Karina, additional, Barde, Marta A., additional, Ajnwojner, Ruth, additional, Wolter, Jan-Sebastian, additional, Haas, Moritz, additional, Roller, Fritz C., additional, Guth, Stefan, additional, Rieth, Andreas J., additional, Rolf, Andreas, additional, Hamm, Christian W., additional, Mayer, Eckhard, additional, Keller, Till, additional, and Liebetrau, Christoph, additional

Published
2020
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46. Exercise right heart catheterization before and after balloon pulmonary angioplasty in inoperable patients with chronic thromboembolic pulmonary hypertension

Author

Wiedenroth, Christoph B., primary, Rieth, Andreas J., additional, Kriechbaum, Steffen, additional, Ghofrani, H.‐Ardeschir, additional, Breithecker, Andreas, additional, Haas, Moritz, additional, Roller, Fritz, additional, Richter, Manuel J., additional, Lankeit, Mareike, additional, Mielzarek, Lisa, additional, Rolf, Andreas, additional, Hamm, Christian W., additional, Mayer, Eckhard, additional, Guth, Stefan, additional, and Liebetrau, Christoph, additional

Published
2020
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